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PSP
MCID: PRM100
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Primary Spontaneous Pneumothorax malady |
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Sources: 17Genetics Home Reference, 23MedlinePlus, 33OMIM, 22MalaCards See all sources Export this MalaCard |
MedlinePlus: Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. between the layers of the pleura is a very thin space. normally it's filled with a small amount of fluid. the fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out.
disorders of the pleura include
pleurisy - inflammation of the pleura that causes sharp pain with breathing
pleural effusion - excess fluid in the pleural space
pneumothorax - buildup of air or gas in the pleural space
hemothorax - buildup of blood in the pleural space
many different conditions can cause pleural problems. viral infection is the most common cause of pleurisy. the most common cause of pleural effusion is congestive heart failure. lung diseases, like chronic obstructive pulmonary disease (copd), tuberculosis, and acute lung injury, cause pneumothorax. injury to the chest is the most common cause of hemothorax. treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition.
nih: national heart, lung, and blood institute23
MalaCards: Primary Spontaneous Pneumothorax, also known as pleural disorders, is related to spontaneous pneumothorax and pneumothorax. An important gene associated with Primary Spontaneous Pneumothorax is FLCN (folliculin), and among its related pathways are Immune response_TLR signaling pathways and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds luminol and peroxynitrite have been mentioned in the context of this disorder. Affiliated tissues include lung and heart. Genetics Home Reference: Primary spontaneous pneumothorax is an abnormal accumulation of air in the space between the lungs and the chest cavity (called the pleural space) that can result in the partial or complete collapse of a lung. This type of pneumothorax is described as primary because it occurs in the absence of lung disease such as emphysema. Spontaneous means the pneumothorax was not caused by an injury such as a rib fracture. Primary spontaneous pneumothorax is likely due to the formation of small sacs of air (blebs) in lung tissue that rupture, causing air to leak into the pleural space. Air in the pleural space creates pressure on the lung and can lead to its collapse. A person with this condition may feel chest pain on the side of the collapsed lung and shortness of breath.17 OMIM: 173600 |
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Sources: 17Genetics Home Reference, 33OMIM, 32Novoseek , 23MedlinePlus See all sources |
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Sources: 33OMIM See all sources |
Clinical features from OMIM: 173600
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for primary spontaneous pneumothorax Drug clinical trials:Search ClinicalTrials for primary spontaneous pneumothorax Search NIH Clinical Center for primary spontaneous pneumothorax Search CenterWatch for primary spontaneous pneumothorax |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to primary spontaneous pneumothorax:22Lung, Heart
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Sources: 35PubMed See all sources |
Articles related to primary spontaneous pneumothorax:
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Sources: 1BioGPS See all sources |
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Sources: 41Thomson Reuters, 10EMD Millipore See all sources |
Pathways related to primary spontaneous pneumothorax according to GeneDecks:
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Sources: 32Novoseek , 18HMDB, 9DrugBank See all sources |
Compounds related to primary spontaneous pneumothorax according to GeneDecks:
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Sources: 12Gene Ontology See all sources |