MCID: PRM022
MIFTS: 40

Primary Syphilis

Categories: Infectious diseases, Neuronal diseases, Bone diseases

Aliases & Classifications for Primary Syphilis

MalaCards integrated aliases for Primary Syphilis:

Name: Primary Syphilis 12 14 69
Early Symptomatic Syphilis 12 69
Early Syphilis, Symptomatic 12
Symptomatic Early Syphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4156
ICD9CM 35 091
SNOMED-CT 64 186846005 57334003
UMLS 69 C0153139

Summaries for Primary Syphilis

Disease Ontology : 12 A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes.

MalaCards based summary : Primary Syphilis, also known as early symptomatic syphilis, is related to parenchymatous neurosyphilis and dysplastic nevus syndrome, and has symptoms including syphilitic chancre An important gene associated with Primary Syphilis is EXTL3 (Exostosin Like Glycosyltransferase 3), and among its related pathways/superpathways are PAK Pathway and CCR5 Pathway in Macrophages. The drugs Penicillin G and Procaine have been mentioned in the context of this disorder. Affiliated tissues include testes, tonsil and tongue.

Related Diseases for Primary Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Primary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 parenchymatous neurosyphilis 10.8 CD40LG MYH9
2 dysplastic nevus syndrome 10.8 DDX41 EXTL3
3 rectum malignant melanoma 10.7 CD40LG DDX41
4 median arcuate ligament syndrome 10.7 CD40LG DDX41
5 diphyllobothriasis 10.7 CD40LG EXTL3
6 malignant hypertensive renal disease 10.7 CD40LG EXTL3
7 amblyopia 10.6 EXTL3 TPR
8 syphilis 10.5
9 opportunistic bacterial infectious disease 10.5 CD40LG DDX41 EXTL3
10 cd40 ligand deficiency 10.5 CD40LG DDX41
11 basilar artery occlusion 10.5 CD40LG EXTL3
12 leukodystrophy 10.5 CD22 CD40LG EXTL3
13 mental depression 10.5 CD40LG MYH9
14 nonspecific interstitial pneumonia 10.4 CCL17 CCL22
15 fallopian tube cystadenofibroma 10.4 CD40LG DDX41 EXTL3 MYH9
16 alopecia areata 10.4 CD40LG DDX41 EXTL3 MYH9
17 malignant eyelid melanoma 10.4 CD40LG DDX41 EXTL3 MYH9
18 transmitted_by 10.4 CD40LG DDX41 EXTL3 MYH9
19 mitochondrial encephalomyopathy 10.4 CD40LG EXTL3
20 blood group incompatibility 10.4 CD40LG EXTL3 MYH9 TPR
21 cerebral neuroblastoma 10.3 CD40LG DDX41 EXTL3 TPR
22 myasthenic syndrome, congenital, 7, presynaptic 10.1 CXCL9 MAPK1
23 erysipelas 10.1 CD40LG NPCDR1
24 cherry allergy 10.0 CCL17 CCL22
25 vascular skin disease 10.0 CD40LG DDX41 EXTL3 MYH9 PDE6D TPR
26 epstein-barr virus, susceptibility to chronic infection by 9.8 CCL17 CCL22 CDKN2B CXCL9
27 tonsillitis 9.7
28 urethritis 9.6
29 dermatitis 9.6
30 herpes simplex 9.6
31 porphyria cutanea tarda 9.5
32 arthritis 9.5
33 balanoposthitis 9.5
34 balanitis 9.5
35 uveitis 9.5
36 porphyria 9.5
37 chancroid 9.5
38 lymphogranuloma venereum 9.5
39 urethral stricture 9.5
40 phimosis 9.5
41 genital herpes 9.5
42 chorioretinitis 9.5
43 ganglioneuroblastoma 4.2 ACMSD CCL17 CCL22 CCL8 CD22 CD40LG

Graphical network of the top 20 diseases related to Primary Syphilis:



Diseases related to Primary Syphilis

Symptoms & Phenotypes for Primary Syphilis

UMLS symptoms related to Primary Syphilis:


syphilitic chancre

Drugs & Therapeutics for Primary Syphilis

Drugs for Primary Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved Phase 4,Phase 3 61-33-6 5904
2
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3 59-46-1 4914
3
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 564-25-0 54671203
4
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
5 Anti-Bacterial Agents Phase 4,Phase 3,Early Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Penicillin G Benzathine Phase 4,Phase 3
8 Penicillin G Procaine Phase 4,Phase 3
9 penicillins Phase 4,Phase 3
10 Antimalarials Phase 4,Phase 3,Early Phase 1
11 Antiparasitic Agents Phase 4,Phase 3,Early Phase 1
12 Antiprotozoal Agents Phase 4,Phase 3,Early Phase 1
13 Anti-HIV Agents Phase 4
14 Anti-Retroviral Agents Phase 4
15 Antiviral Agents Phase 4
16 Nucleic Acid Synthesis Inhibitors Phase 4
17 Reverse Transcriptase Inhibitors Phase 4
18
Tenofovir Phase 4 147127-20-6 464205
19
Guaifenesin Approved, Vet_approved Phase 3 93-14-1 3516
20
Heroin Approved, Illicit Phase 3 561-27-3 5462328
21
Methadone Approved Phase 3 76-99-3 4095
22
Azithromycin Approved Phase 3 83905-01-5 55185 53477736 447043
23
chloroquine Approved, Vet_approved Phase 3 54-05-7 2719
24
Pyrimethamine Approved, Vet_approved Phase 3 58-14-0 4993
25
Sulfadoxine Approved Phase 3 2447-57-6 17134
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
27
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
28 Analgesics Phase 3
29 Analgesics, Opioid Phase 3
30 Antitussive Agents Phase 3
31 Central Nervous System Depressants Phase 3
32 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
33 Narcotics Phase 3
34 Peripheral Nervous System Agents Phase 3
35 Respiratory System Agents Phase 3
36 Analgesics, Non-Narcotic Phase 3
37 Anthelmintics Phase 3
38 Anti-Inflammatory Agents Phase 3
39 Anti-Inflammatory Agents, Non-Steroidal Phase 3
40 Antirheumatic Agents Phase 3
41 Chloroquine diphosphate Phase 3 50-63-5
42 Fanasil, pyrimethamine drug combination Phase 3
43 Folic Acid Antagonists Phase 3
44 Renal Agents Phase 3
45 Vitamin B Complex Phase 3
46 Folate Nutraceutical Phase 3
47 Vitamin B9 Nutraceutical Phase 3
48 Antibodies Phase 1
49 Autoantibodies Phase 1
50 Immunoglobulin M Phase 1

Interventional clinical trials:

(show top 50) (show all 72)

id Name Status NCT ID Phase Drugs
1 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
2 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
3 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
4 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Not yet recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
5 PrEP Implementation for Mothers in Antenatal Care Not yet recruiting NCT03070600 Phase 4 Universal PrEP Counseling;Targeted PrEP Counseling
6 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
7 Injecting Drug Use Community Intervention Trial Unknown status NCT01108614 Phase 3
8 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
9 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
10 Effectiveness of a Community-level HIV/STD Prevention Intervention in Promoting Safer Sexual Behaviors in High-risk Populations Completed NCT00710060 Phase 3
11 MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania Completed NCT00248469 Phase 3
12 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3
13 Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission Completed NCT00213083 Phase 3 Carraguard (PC-515)
14 Expanded PrEP Implementation in Communities in NSW Recruiting NCT02870790 Phase 3 TDF/FTC
15 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3 Azithromycin plus chloroquine;sulfadoxine-pyrimethamine
16 Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
17 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
18 Safety and Efficacy Study of Human Autologous Hair Follicle Cells to Treat Androgenetic Alopecia Completed NCT01286649 Phase 1, Phase 2
19 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico Completed NCT00840658 Phase 2
20 Lay Health Advisors for Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
21 Safer Sex Program for Young African-American Men Recruiting NCT01439503 Phase 2
22 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
23 Fecal Microbiota Transplantation in Pediatric Patients Completed NCT02108821 Phase 1
24 Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand Completed NCT00213057 Phase 1 Carraguard (PC-515)
25 Syphilis Treatment of Partners Trial Unknown status NCT02262390
26 Evaluation of Therapeutic Management in ESBL-infected Patients or Carriers by Providing and Sharing a Free Tool - the "ESBL toolKIT"and Interventional Study of a Prospective Cohort of HIV+ Patients Searching for Possible Sexual Transmission Factors in ESB Unknown status NCT02011009
27 A Methadone Maintenance Treatment Outcome Study in Three Provinces in China Unknown status NCT01315054
28 The Impact of Short-term Financial Incentives on Sexual Behavior and HIV Incidence in Lesotho Unknown status NCT01589965 Early Phase 1
29 MBCGT and Psycho-physiological Stress Regulation Group for Depression and Psycho-physiological Stress Patient Unknown status NCT01894932
30 The Contraceptive Choice Project Unknown status NCT01986439
31 Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM) Unknown status NCT01300689
32 Comparisons of Serologic Response of Early Syphilis Completed NCT01944358
33 Feasibility of Introducing an Onsite Test for Syphilis in the Package of Antenatal Care in Burkina Faso Completed NCT03156751
34 Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission Completed NCT00553111
35 Syphilis Video Tool to Promote Knowledge and Testing in the ED Completed NCT00552539
36 Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM Completed NCT02257658 Doxycycyline
37 Behavioral Science Aspects of Rapid Test Acceptance Completed NCT01317784
38 Prevention of HIV and STDs in Drug Using Women Completed NCT01235091
39 Implementation of an Efficacious Intervention for High Risk Women in Mexico Completed NCT01465607
40 Rewarding Sexually Transmitted Infection (STI) Prevention and Control in Tanzania Completed NCT00922038
41 Partner Notification Strategies for MSM in Peru Completed NCT01720641
42 Project RESPECT: The Efficacy of HIV/STD Prevention Counseling Completed NCT00362791
43 Evaluation of Enhanced Syphilis Screening Among HIV-positive Men Completed NCT02019043
44 Multi-site Study of Rapid Diagnostic Syphilis Assays Completed NCT00300534
45 Dual Rapid HIV & Syphilis Tests in Zambia Completed NCT02445846
46 Evaluation of the MBio Combined Syphilis/HIV Point-of-Care Diagnostic Test Completed NCT01530672
47 Evaluating the Effectiveness of Point-of-care Diagnostic Technologies in MCH Services in Mozambique Completed NCT02191527
48 Repeat Sexually Transmitted Infection (STI) Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk Completed NCT01510262
49 Utilization of the Community Popular Opinion Leader (C-POL) Model in Alabama Completed NCT00260754
50 A Community-Based Intervention With Popular Opinion Leaders (C-POL) in Texas Completed NCT00260715

Search NIH Clinical Center for Primary Syphilis

Genetic Tests for Primary Syphilis

Anatomical Context for Primary Syphilis

MalaCards organs/tissues related to Primary Syphilis:

39
Testes, Tonsil, Tongue, Lymph Node

Publications for Primary Syphilis

Articles related to Primary Syphilis:

(show top 50) (show all 122)
id Title Authors Year
1
Primary syphilis in a secondary stage. ( 28755824 )
2017
2
Kissing chancre of primary syphilis. ( 28070492 )
2017
3
Unusual primary syphilis: Presentation of a likely case with a review of the stages of acquired syphilis, its differential diagnoses, management, and current recommendations. ( 26756536 )
2016
4
Primary syphilis: An uncommon manifestation in the oral cavity. ( 27502894 )
2016
5
Painful and multiple anogenital lesions are common in men with Treponema pallidum PCR-positive primary syphilis without herpes simplex virus coinfection: a cross-sectional clinic-based study. ( 26378262 )
2015
6
Oral and Maxillofacial Pathology. Case of the Month. Primary Syphilis. ( 26357808 )
2015
7
An erythematous nodule on the nipple: An unusual presentation of primary syphilis. ( 25940793 )
2015
8
Balanoposthitis and Penile Edema: Atypical Manifestations of Primary Syphilis. ( 26267879 )
2015
9
Multiple primary syphilis on the lip, nipple-areola and penis: An immunohistochemical examination of Treponema pallidum localization using an anti-T.A pallidum antibody. ( 25708895 )
2015
10
Tonsillar chancre as unusual manifestation of primary syphilis. ( 25933085 )
2015
11
Use of Treponema pallidum PCR in testing of ulcers for diagnosis of primary syphilis. ( 25531672 )
2015
12
Indurative Edema of the Prepuce Mimicing Phimosis, an Atypical Manifestation of Primary Syphilis. ( 26724885 )
2015
13
Primary syphilis presenting as bilateral nipple-areola eczematoid lesions. ( 24448719 )
2014
14
Primary syphilis of the oropharynx: unusual location of a chancre. ( 25193247 )
2014
15
Evaluation of diagnostic serological results in cases of suspected primary syphilis infection. ( 24722379 )
2014
16
Primary syphilis in HIV-negative patients is on the rise in Greece: epidemiological data for the period 2005-2012 from a tertiary referral centre in Athens, Greece. ( 25327583 )
2014
17
Atypical pearly penile papules mimicking primary syphilis. ( 25580796 )
2014
18
Chancre of the eyelid as manifestation of primary syphilis, and precocious chorioretinitis and uveitis in an HIV-infected patient: a case report. ( 23006858 )
2012
19
Clinical manifestations of primary syphilis in homosexual men. ( 22846130 )
2012
20
Primary syphilis of the urethral meatus complicated by urethral stricture. ( 21890554 )
2011
21
Primary syphilis of the finger. ( 20531029 )
2010
22
Primary syphilis cases in Guangdong Province 1995-2008: opportunities for linking syphilis control and regional development. ( 21192782 )
2010
23
Clarithromycin treatment failure due to macrolide resistance in Treponema pallidum in a patient with primary syphilis. ( 20169316 )
2010
24
Multiple ulcers in primary syphilis with negative rapid plasma reagin and Venereal Disease Research Laboratory tests: an unusual presentation during the re-emergence of syphilis in Albania. ( 20215630 )
2010
25
The Architect Syphilis assay for antibodies to Treponema pallidum: an automated screening assay with high sensitivity in primary syphilis. ( 18790859 )
2009
26
Mondor's disease of the penis associated with primary syphilis. ( 19541898 )
2009
27
Macrolide resistance and molecular types of Treponema pallidum causing primary syphilis in Shanghai, China. ( 19583516 )
2009
28
Expedited intervention services for possible occult primary syphilis among MSM with asymptomatic incident syphilis. ( 19661841 )
2009
29
Rectal cancer or rectal chancre? Beware of primary syphilis. ( 18313998 )
2008
30
Primary syphilis. ( 18397550 )
2008
31
Pseudotumoral primary syphilis on the tongue in an HIV positive patient. ( 18355362 )
2008
32
Primary syphilis on the finger. ( 18663310 )
2008
33
Unilateral penile swelling: an unusual presentation of primary syphilis? ( 18725559 )
2008
34
Male patient with a genital ulceration. Primary syphilis. ( 18246892 )
2008
35
Primary syphilis: serological treatment response to doxycycline/tetracycline versus benzathine penicillin. ( 18823862 )
2008
36
Acquired primary syphilis on a child's lip. ( 17533506 )
2007
37
The influence of concomitant HIV infection on the serological diagnosis of primary syphilis in southern Africa. ( 18250927 )
2007
38
An evaluation of the relative sensitivities of the venereal disease research laboratory test and the Treponema pallidum particle agglutination test among patients diagnosed with primary syphilis. ( 18080352 )
2007
39
Primary syphilis presenting as balanitis. ( 17623510 )
2007
40
Case series descriptive analysis of a primary syphilis outbreak in Edmonton, Alberta, July 2004-April 2006. ( 17520772 )
2007
41
Presternal indurated ulceration: primary syphilis. ( 16484829 )
2006
42
A case of primary syphilis in the rectum. ( 16224168 )
2005
43
Genital lesions of primary syphilis. ( 14722141 )
2004
44
Primary syphilis of oral mucosa: case report of an unusual manifestation. ( 15470997 )
2004
45
Primary syphilis. ( 17656890 )
2002
46
A patient with primary syphilis of the finger. ( 11800158 )
2001
47
Atypical manifestation of primary syphilis. ( 10866591 )
2000
48
Primary syphilis remains a cause of oral ulceration. ( 11081944 )
2000
49
Comparative evaluation of nine different enzyme-linked immunosorbent assays for determination of antibodies against Treponema pallidum in patients with primary syphilis. ( 10699042 )
2000
50
Chancroid, primary syphilis, genital herpes, and lymphogranuloma venereum in Antananarivo, Madagascar. ( 10479178 )
1999

Variations for Primary Syphilis

Expression for Primary Syphilis

Search GEO for disease gene expression data for Primary Syphilis.

Pathways for Primary Syphilis

GO Terms for Primary Syphilis

Biological processes related to Primary Syphilis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.89 CCL17 CCL22 CCL8 CD40LG CXCL9
2 cell-cell signaling GO:0007267 9.81 CCL17 CCL22 CCL8 CXCL9
3 inflammatory response GO:0006954 9.8 CCL17 CCL22 CCL8 CD40LG CXCL9
4 cellular response to tumor necrosis factor GO:0071356 9.7 CCL17 CCL22 CCL8
5 cellular response to interleukin-1 GO:0071347 9.65 CCL17 CCL22 CCL8
6 neutrophil chemotaxis GO:0030593 9.63 CCL17 CCL22 CCL8
7 cellular response to interferon-gamma GO:0071346 9.61 CCL17 CCL22 CCL8
8 monocyte chemotaxis GO:0002548 9.54 CCL17 CCL22 CCL8
9 lymphocyte chemotaxis GO:0048247 9.33 CCL17 CCL22 CCL8
10 response to epidermal growth factor GO:0070849 9.32 MAPK1 TPR
11 MAPK import into nucleus GO:0000189 9.26 MAPK1 TPR
12 chemokine-mediated signaling pathway GO:0070098 9.26 CCL17 CCL22 CCL8 CXCL9
13 chemotaxis GO:0006935 9.02 CCL17 CCL22 CCL8 CXCL9 MAPK1

Molecular functions related to Primary Syphilis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.55 CCL17 CCL22 CCL8 CD40LG CXCL9
2 protein anchor GO:0043495 9.26 MYH9 TPR
3 CCR chemokine receptor binding GO:0048020 9.13 CCL17 CCL22 CCL8
4 chemokine activity GO:0008009 8.92 CCL17 CCL22 CCL8 CXCL9

Sources for Primary Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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