Primitive Neuroectodermal Tumor malady

MalaCards: Primitive Neuroectodermal Tumor, also known as localized primitive neuroectodermal tumor, is related to supratentorial primitive neuroectodermal tumor and cerebral primitive neuroectodermal tumor. An important gene associated with Primitive Neuroectodermal Tumor is MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)), and among its related pathways are Colorectal cancer and Pancreatic cancer. The compounds vincristine and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include brain, small intestine and kidney, and related mouse phenotypes are liver/biliary system and respiratory system.

Aliases & Descriptions:

primitive neuroectodermal tumor 6 localized primitive neuroectodermal tumor 6 43 extraosseous ewings sarcoma-primitive neuroepithelial tumor 43 primitive neuroectodermal tumour 6

neuroectodermal tumor, primitive 43 cns pnet 6 cpnet 6

Diseases related to primitive neuroectodermal tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 824)

id	Related Disease	Score	Top Affiliating Genes
1	supratentorial primitive neuroectodermal tumor	37.4	MYC, MYCN, MYB, RASSF1, S100B, MPRIP
2	cerebral primitive neuroectodermal tumor	36.3	MYC, MYCN, S100B, MSH2, IFNB1, TP53
3	peripheral primitive neuroectodermal tumor	35.9	KIT, KITLG, RB1, BCL2, CDKN2A, CDK4
4	ewing's family of tumors	34.1	NCAM1, VIM, MYC, MYCN, CHGA, CDK4
5	pineoblastoma	33.0	CADPS, TP53, GFAP, SYP
6	rhabdoid tumors	32.9	VIM, MUC1, IGF1R, PTPRC, SMARCB1, WT1
7	atypical teratoid rhabdoid tumor	32.9	VIM, RASSF1, MUC1, IGF1R, TP53, SMARCB1
8	extraosseous ewing's sarcoma	31.9	S100B, CD99, EWSR1, ETV4
9	askin's tumor	31.7	S100B, ENO2, NTRK1, NGF
10	lymphoblastic lymphoma	31.5	VIP, CD99, FLI1, ENO2, PTPRC, NOTCH1
11	olfactory neuroblastoma	31.2	VIM, S100B, CDKN1A, EWSR1, NTRK1, NTRK2
12	ganglioneuroma	31.1	NCAM1, VIP, MYCN, RASSF1, SCG2, CHGA
13	childhood medulloblastoma	30.8	MYC, CDKN2A, APC, CADPS, PTCH1, PTPRC
14	leydig cell tumor	30.6	KIT, VIM, MUC1, APC, ENO2, TP53
15	synovial sarcoma	30.1	KIT, VIM, MYCN, RASSF1, BCL2, MUC1
16	neuroepithelioma	29.7	NCAM1, KITLG, MYC, MYCN, CD99, FLI1
17	glioblastoma	29.5	RB1, MYCN, KDR, MSH2, CDKN1A, CDKN2A
18	ependymoma	27.5	NCAM1, RB1, VIM, RASSF1, MUC1, S100B
19	medulloblastoma	27.1	NCAM1, KIT, RB1, SERPINF1, VIM, VIP
20	basal cell carcinoma	26.5	MYCN, BMP2, BCL2, MUC1, S100B, MSH2
21	wilms tumor	25.6	NCAM1, SERPINF1, VIM, MYC, MYCN, MYB
22	neuroectodermal tumors	25.3	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
23	soft tissue sarcoma	24.8	KIT, KITLG, RB1, VIM, MYC, BMP2
24	cerebritis	24.4	NCAM1, KITLG, VIM, VIP, VIPR1, MYC
25	sarcoma	24.1	NCAM1, KIT, KITLG, RB1, VIM, VIP
26	malignant glioma	21.9	KIT, KITLG, RB1, VIM, MYC, RAF1
27	astrocytoma	21.0	NCAM1, KIT, RB1, VIM, MYC, RAF1
28	neuroblastoma	20.1	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
29	hypoxia	19.7	KIT, KITLG, RB1, SERPINF1, VIP, MYC
30	neuronitis	17.1	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
31	carcinoma	16.0	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
32	supratentorial neoplasm	14.1	CHGA, CD99, ENO2, SYP
33	giant cell glioblastoma	14.1	VIM, S100B, MDM2, TP53, PTEN, GFAP
34	pineocytoma	14.1	CHGA, S100B, ENO2, GFAP, SYNM, SYP
35	chordoid glioma	14.1	VIM, MUC1, S100B, CDK4, GFAP, SYP
36	choroid plexus papilloma	14.1	MUC1, S100B, GFAP, SYP
37	papillary ependymoma	14.1	S100B, GFAP, SYP
38	granulosa cell tumor of the ovary	14.1	VIM, CHGA, ENO2, TP53, SYP
39	mixed cell type cancer	14.1	VIM, ENO2, TP53, GFAP, DES
40	dysembryoplastic neuroepithelial tumor	14.1	CHGA, S100B, TP53, GFAP, SYP, NES
41	peripheral neuroblastoma	14.1	CHGA, S100B, SYP
42	congenital epulis	14.1	VIM, S100B, ENO2, DES
43	gastric small cell carcinoma	14.1	NCAM1, CHGA, ENO2, SYP
44	adrenal cortical carcinoma	14.1	VIM, MUC1, S100B, TP53, DES
45	pituitary carcinoma	14.1	CHGA, MUC1, ASCL1, TP53, SSTR2, GFAP
46	subependymal giant cell astrocytoma	14.1	VIM, S100B, TP53, GFAP, SYP, NES
47	orbit rhabdomyosarcoma	14.1	VIM, MDM2, ENO2, TP53, DES
48	anaplastic ependymoma	14.1	MUC1, S100B, MDM2, PTEN, GFAP
49	epithelioid leiomyosarcoma	14.1	VIM, ENO2, PTPRC, DES
50	chordoid meningioma	14.1	NCAM1, VIM, MUC1, S100B, GFAP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to primitive neuroectodermal tumor:

²²

MGI Mouse Phenotypes related to primitive neuroectodermal tumor:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	10.1	TH, KIT, MYCN, NGFR, SMARCB1, SMARCA4
2	respiratory system phenotype	MP:0005388	10.0	NEUROD1, TH, SMO, SMARCA4, NTF3, DICER1
3	endocrine/exocrine gland phenotype	MP:0005379	9.9	NEUROD1, PMS2, KRAS, WT1, EWSR1, ASCL1
4	craniofacial phenotype	MP:0005382	9.3	PDGFRA, NOTCH1, SMO, DICER1, PTCH1, IGF1R
5	no phenotypic analysis	MP:0003012	8.8	PTGS2, DICER1, NTRK1, SYP, SOX1, NEUROG1
6	embryogenesis phenotype	MP:0005380	8.4	SMO, SMARCB1, SMARCA5, SMARCA4, SS18, DICER1
7	limbs/digits/tail phenotype	MP:0005371	8.4	DICER1, NTRK1, SMARCA4, SMO, NGFR, PDGFRA
8	hematopoietic system phenotype	MP:0005397	8.0	KRAS, KRT8, PDGFRA, NOTCH1, SMARCB1, NTRK1
9	renal/urinary system phenotype	MP:0005367	7.7	PTPRC, DDC, SMARCA4, NOTCH1, NGFR, PDGFRA
10	pigmentation phenotype	MP:0001186	7.6	TP53, PTCH1, PTEN, NTRK1, SMARCA5, NOTCH1
11	immune system phenotype	MP:0005387	7.6	PMS2, STAT3, DNTT, GFAP, KRAS, TP53
12	reproductive system phenotype	MP:0005389	7.6	AKT3, ETV4, EWSR1, CASP3, APC, FUS
13	normal phenotype	MP:0002873	7.5	STAT3, NTF3, DICER1, PTPRC, PTCH1, TNC
14	integument phenotype	MP:0010771	7.3	SLITRK5, CSF3, TH, KRAS, PDGFRA, NGFR
15	adipose tissue phenotype	MP:0005375	6.9	IGF1, EWSR1, TP53, TNF, PTEN, PTGS2
16	digestive/alimentary phenotype	MP:0005381	6.8	SSTR2, MUC1, BCL2, BMP2, MYCN, MYC
17	behavior/neurological phenotype	MP:0005386	6.8	SPARC, MDM2, ASCL1, CDKN1A, FUS, S100B
18	hearing/vestibular/ear phenotype	MP:0005377	6.6	DMBT1, NTRK1, NTRK2, NTRK3, SMO, NOTCH1
19	skeleton phenotype	MP:0005390	5.9	TP53, ETV4, CASP3, ID1, IFNB1, PTCH1
20	mortality/aging	MP:0010768	5.8	DSG2, NTRK3, NTRK2, NTRK1, NTF3, SS18
21	nervous system phenotype	MP:0003631	5.6	SLITRK5, SLITRK6, SOX1, STAT3, SYP, TGFB2
22	vision/eye phenotype	MP:0005391	4.9	SPARC, CDKN1A, MUC1, BCL2, KDR, RAF1
23	tumorigenesis	MP:0002006	4.9	PMS2, STAT3, KRAS, PDGFRA, NOTCH1, AKT3
24	muscle phenotype	MP:0005369	4.9	IRS1, KIT, RB1, CDK4, CDKN2A, CDKN1A
25	cardiovascular system phenotype	MP:0005385	2.5	NOTCH1, TNF, TP53, CASP3, ID1, IGF1
26	growth/size phenotype	MP:0005378	2.4	GFAP, KRAS, KRT18, KRT8, WT1, PDGFRA
27	cellular phenotype	MP:0005384	2.2	ID1, CDKN2A, CDKN1A, FUS, ATF1, MSH2
28	homeostasis/metabolism phenotype	MP:0005376	1.4	KDR, KIT, KITLG, RASSF1, RAF1, BMP2

Articles related to primitive neuroectodermal tumor:

(show top 50)    (show all 121)

id	Title	Authors	Year	Affiliating Genes
1	Upregulation of SOX2, NOTCH1, and ID1 in supratentori al primitive neuroectodermal tumors: a distinct differentiation pattern from th at of medulloblastomas. (20515335)	Phi J.H.... Kim S.K.	2010	STAT3, NOTCH1, ASCL1
2	Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. (18452568)	Perry A.... Rosenblum M.K.	2009	MYC
3	p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor. (19147556)	Saab R.... Skapek S.X.	2009	CDK4
4	RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system. (17899687)	Inda M.M.... Castresana J.S.	2007	RASSF1
5	Primitive neuroectodermal tumor of the breast: immunohistochemistry and fluorescence in situ hybridization. (17610475)	Tamura G.... Hasegawa T.	2007	CD99
6	Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype. (17063089)	Haberler C.... Hainfellner J.A.	2006	SMARCB1
7	Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays. (18095118)	Kagawa N.... Yoshimine T.	2006	AKT3
8	Primitive neuroectodermal tumor: rare, highly aggressive differential diagnosis in urologic malignancies. (16904430)	Ellinger J.... MA1ller S.C.	2006	SYP
9	High-dose chemotherapy with autologous stem cell resc ue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors. (15719272)	PAcrez-MartA-nez A.... Madero L.	2005	CSF3
10	A general aspect on soft-tissue sarcoma and c-kit expression in primitive neuroectodermal tumor and Ewing's sarcoma. Is there any role in disease process? (16127511)	Kara I.O.... Erdogan S.	2005	KITLG
11	Clinicopathological study of Ewing's sarcoma/primitive neuroectodermal tumor in oral and maxillofacial region (16255919)	He H.W.... He Z.X.	2005	CD99, S100A1, SYNM
12	Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation. (15920547)	Schuetz A.N.... Folpe A.L.	2005	DSG2
13	Primary subcutaneous primitive neuroectodermal tumor with aggressive behavior and an unusual karyotype: case report. (15547779)	Somers G.R.... Ngan B.Y.	2004	S100B
14	Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators. (15289350)	Batra S.... Maurer B.J.	2004	ASAH1, ASAH2
15	PTEN and DMBT1 homozygous deletion and expression in medulloblastomas and supratentorial primitive neuroectodermal tumors. (15547761)	Inda M.M.... Castresana J.S.	2004	PTEN, DMBT1
16	Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone. (12883251)	Collini P.... Pilotti S.	2003	SYP
17	A novel case of a CAT to AAT transversion in codon 179 of the p53 gene in a supratentorial primitive neuroectodermal tumor harbored by a young girl. Case report and review of the literature. (12837982)	Postovsky S.... Amikam D.	2003	TP53
18	Primary cutaneous pre-B lymphoblastic lymphoma immunohistologically mimics Ewing's sarcoma/primitive neuroectodermal tumor. (12783138)	Hsiao C.H.... Su I.J.	2003	PTPRC, DNTT
19	Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. (11859203)	Jimenez R.E.... Amin M.B.	2002	FLI1
20	Cytogenetic and histopathologic studies of congenital supratentorial primitive neuroectodermal tumors: a case report. (11349224)	Girschick H.J.... KA1hl J.	2001	MYCN
21	Primary Ewing's sarcoma/peripheral primitive neuroectodermal tumor at the vertex of the skull with elevated serum carcinoembryonic antigen: case report. (11508817)	Tamiya T.... Ohmoto T.	2001	PSG2
22	Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors. (11433413)	Koch A.... Pietsch T.	2001	APC
23	Primitive neuroectodermal tumor of the kidney associated with Budd-Chiari syndrome in a 17-year-old girl. (11695280)	Juan C.J.... Fan H.C.	2001	PTPRC, CHGA
24	Autocrine secreted insulin-like growth factor-I stimulates MAP kinase-dependent mitogenic effects in human primitive neuroectodermal tumor/medulloblastoma. (10675492)	Patti R.... Phillips P.C.	2000	MAPK10
25	Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint. (11146561)	Kim J.S.... Trepel J.B.	2000	RB1
26	Neurotrophins and Trk receptors in primitive neuroectodermal tumor cell lines. (10549931)	Chiappa S.A.... Raffel C.	1999	NTRK1, NTRK2, NTRK3
27	Neuroendocrine differentiation in Ewing's sarcomas and primitive neuroectodermal tumors revealed by reverse transcriptase-polymerase chain reaction of chromogranin mRNA. (9646033)	Pagani A.... Bussolati G.	1998	CHGA, SCG2
28	Peripheral primitive neuroectodermal tumors in adults: documentation by molecular analysis. (9508202)	Lawlor E.R.... Sorensen P.H.	1998	EWSR1, ETV7
29	Renal primitive neuroectodermal tumor: a morphologic, cytogenetic, and molecular analysis with the establishment of two cultured cell lines. (9559290)	Takeuchi T.... Kikuchi M.	1997	EWSR1
30	p21 (WAF1/Cip1/Sdi1/Pic1) mRNA is expressed in neuroblastoma cell lines but not in Ewing's sarcoma and primitive neuroectodermal tumor cell lines. (9363658)	Maeda T.... Sano K.	1997	CDKN1A
31	Chromosome arm 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system. (9242214)	Burnett M.E.... Cogen P.H.	1997	TP53
32	Is the EWS/FLI-1 fusion transcript specific for Ewing sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types. (8644855)	Thorner P.... Zielenska M.	1996	MDM2
33	Olfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcoma. (8577710)	Sorensen P.H.... Triche T.J.	1996	EWSR1
34	Primitive neuroectodermal tumor of the myocardium: a case report, review of the literature, immunohistochemical, and ultrastructural study. (8958313)	Charney D.A.... Teplitz C.	1996	ENO2
35	Coexpression of platelet-derived growth factor alpha and beta receptors on medulloblastomas and other primitive neuroectodermal tumors is consistent with an immature stem cell and neuronal derivation. (8569181)	Smits A.... NistAcr M.	1996	VIM, NES
36	Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in chil dren and young adults. (7595741)	Kushner B.H.... Heller G.	1995	CSF3
37	EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor. (7591257)	Ida K.... Hayashi Y.	1995	ERG
38	Human interferon-beta therapy for cerebral primitive neuroectodermal tumors--two case reports. (7753313)	Tanaka S.... Nagashima T.	1995	IFNB1
39	Expression of N-myc, c-myc and c-erbB-1 proto-oncogenes in cerebral primitive neuroectodermal tumors (PNET). (7889335)	Debiec-Rychter M.... Liberski P.P.	1994	MYC, MYCN
40	A case of primitive neuroectodermal tumor in the chest wall ('Askin's tumor') (8176303)	Inada K.... Matsuda H.	1994	ENO2
41	Reverse transcriptase PCR amplification of EWS/FLI-1 fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumors of childhood. (7506981)	Sorensen P.H.... Triche T.J.	1993	FLI1, EWSR1
42	Monoclonal antibodies to a rat nestin fusion protein recognize a 220-kDa polypeptide in subsets of fetal and adult human central nervous system neurons and in primitive neuroectodermal tumor cells. (7686344)	Tohyama T.... Trojanowski J.Q.	1993	NES
43	Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors. (1342962)	Pagani A.... Bussolati G.	1992	CHGA, CHGB, SCG2
44	Desmin positivity in primitive neuroectodermal tumors of childhood. (1599027)	Parham D.M.... Houghton P.	1992	DES
45	A continuous cell line (KK-2) from a supratentorial primitive neuroectodermal tumor. (1323907)	Ito H.... Kawano N.	1992	TH, S100B, DDC
46	Immunohistochemistry of primitive neuroectodermal tumors in infants with special emphasis on cytokeratin expression. (1723829)	Grieshammer T.... Vogeley K.T.	1991	KRT18, KRT8, KRT13
47	MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. (1848471)	Ambros I.M.... Salzer-Kuntschik M.	1991	CD99
48	Immunohistochemical characterization of primitive neuroectodermal tumors and their possible relationship to the stepwise ontogenetic development of the central nervous system. 2. Tumor studies. (1664631)	Kleinert R.	1991	ENO2
49	Primitive neuroectodermal tumors of the central nervous system. Patterns of expression of neuroendocrine markers, and all classes of intermediate filament proteins. (2159086)	Gould V.E.... Franke W.W.	1990	SYP, GRP
50	Immunophenotype profile of childhood medulloblastomas and supratentorial primitive neuroectodermal tumors using 16 monoclonal antibodies. (2196109)	Zeltzer P.M.... Kemshead J.	1990	PTPRC

Genes related to primitive neuroectodermal tumor according to GeneCards:

(show top 50)    (show all 120)

id	Symbol	Description	Score	GeneCards Section Context
1	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
2	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
3	GFAP	glial fibrillary acidic protein	11.0	Publications
4	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.0	Summaries
5	CD99	CD99 molecule	11.0	Publications
6	SYP	synaptophysin	11.0	Publications
7	EWSR1	Ewing sarcoma breakpoint region 1	11.0	Publications
8	SSTR2	somatostatin receptor 2	11.0	Publications
9	ETV7	ets variant 7	11.0	Publications
10	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
11	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
12	GRP	gastrin-releasing peptide	11.0	Publications
13	S100B	S100 calcium binding protein B	11.0	Publications
14	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
15	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
16	TP53	tumor protein p53	11.0	Publications
17	SLITRK3	SLIT and NTRK-like family, member 3	11.0	Expressions
18	SLITRK5	SLIT and NTRK-like family, member 5	11.0
19	SLITRK2	SLIT and NTRK-like family, member 2	11.0	Expressions
20	SLITRK6	SLIT and NTRK-like family, member 6	11.0	Expressions
21	SLITRK4	SLIT and NTRK-like family, member 4	11.0	Expressions
22	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
23	FLI1	Friend leukemia virus integration 1	11.0	Publications
24	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
25	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	11.0
26	NGFR	nerve growth factor receptor	11.0	Publications
27	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
28	DMBT1	deleted in malignant brain tumors 1	11.0	Publications
29	MYB	v-myb myeloblastosis viral oncogene homolog (avian)	11.0	Publications
30	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	11.0
31	PTCH1	patched 1	11.0	Publications
32	DES	desmin	11.0	Publications
33	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
34	PRMT8	protein arginine methyltransferase 8	11.0
35	ATF1	activating transcription factor 1	11.0
36	ETV1	ets variant 1	11.0
37	VIM	vimentin	11.0	Publications
38	TNC	tenascin C	11.0
39	CDK4	cyclin-dependent kinase 4	11.0	Publications
40	TH	tyrosine hydroxylase	11.0	Publications
41	ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	11.0	Publications
42	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
43	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	11.0	Publications
44	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
45	MUC1	mucin 1, cell surface associated	11.0	Publications
46	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications
47	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
48	PTEN	phosphatase and tensin homolog	11.0	Publications
49	TNF	tumor necrosis factor	11.0	Publications
50	NCAM1	neural cell adhesion molecule 1	11.0

Pathways related to primitive neuroectodermal tumor according to GeneDecks:

(show top 50)    (show all 209)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.5	MSH2, AKT3, TGFB2
2	Pancreatic cancer20	10.5	AKT3
3	Signal transduction_PTEN pathway41	10.4	IGF1R, IRS1
4	Apoptosis and survival Role of CDK5 in neuronal death and survival10	9.6	AKT3, NTRK1, NGF, BCL2
5	Neuroscience3	9.5	NTRK1, DDC, PTGS2, NEUROD1, S100B, MYCN
6	Akt Signaling36	9.4	KIT, TGFB2, PDGFRA, NGFR, NTRK3, NTF3
7	Bladder cancer20	9.3	CDK4, MDM2, TP53, KRAS, MAPK3, CDKN2A
8	Development Neurotrophin family signaling10	9.2	NTRK2, TP53, AKT3, NTRK1, NGF, NGFR
9	Glioblastoma Multiforme36	9.2	PDGFRA, PTEN, TP53, AKT3, IGF1R, MAPK3
10	Development_Neurotrophin family signaling41	9.2	NTRK1, RAF1, MAPK3, MAPK10, NTF3, TP53
11	PTEN Pathway36	9.0	KIT, KITLG, PTEN, NTF3, NTRK1, NTRK2
12	Neurotrophin signaling pathway20	9.0	NTRK1, RAF1, IRS1, MAPK3, MAPK10, AKT3
13	Breast Cancer Regulation by Stathmin136	9.0	NTRK1, MAPK10, NTF3, IGF1R, CCNB3, NTRK2
14	Chronic myeloid leukemia20	8.9	CDK4, RB1, MDM2, TGFB2, KRAS, TP53
15	Signal transduction PTEN pathway10	8.7	CASP3, IRS1, PTEN, AKT3, IGF1, IGF1R
16	ERK5 Signaling36	8.6	KDR, KIT, KITLG, MYC, BMP2, PDGFRA
17	ERK Signaling36	8.5	IL1A, BMP2, RAF1, ATF1, IL1B, MAPK3
18	PPAR Pathway36	8.5	IGF1R, BMP2, KIT, KITLG, RAF1, NTRK3
19	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	8.5	RAF1, NGFR, NGF, NTRK1, TP53, AKT3
20	Apoptotic Pathways in Synovial Fibroblasts36	8.5	KDR, TGFB2, IGF1R, BMP2, KITLG, KIT
21	Glioma20	8.4	RB1, RAF1, KRAS, PDGFRA, PTEN, TP53
22	Melanoma20	8.4	TP53, AKT3, IGF1, IGF1R, MAPK3, CDK4
23	Telomerase Components in Cell Signaling36	8.3	KITLG, TP53, KDR, KIT, NGFR, RB1
24	eIF2 Pathway36	8.2	NTRK3, NTRK1, PDGFRA, TGFB2, NTF3, IGF1
25	Rac1 Pathway36	8.1	RAF1, KITLG, NTF3, TGFB2, NGFR, NTRK3
26	Endothelin-1 Signaling Pathway36	8.1	RAF1, IL1A, IL1B, MAPK3, MAPK10, IGF1R
27	14-3-3 Induced Intracellular Signaling36	8.1	BMP2, RAF1, KITLG, TNF, NTRK1, MAPK10
28	MAPK signaling pathway20	7.7	MAPK10, IL1B, TGFB2, TP53, AKT3, CASP3
29	Prostate cancer20	7.7	BCL2, RAF1, RB1, MDM2, MAPK3, IGF1R
30	JNK Pathway36	7.6	KITLG, RAF1, PDGFRA, NTRK3, KDR, BCL2
31	Activation of PKC through GPCR36	7.5	NTRK3, NGFR, PDGFRA, TGFB2, NTRK2, NTF3
32	p70S6K Signaling36	7.4	KITLG, IGF1R, PDGFRA, TGFB2, IGF1, MAPK10
33	Nanog in Mammalian ESC Pluripotency36	7.4	NTRK2, TGFB2, NTRK1, NTF3, IGF1R, MAPK3
34	p53 Mediated Apoptosis36	7.3	TGFB2, KDR, BMP2, KITLG, KIT, BCL2
35	Mitochondrial Apoptosis36	7.3	TGFB2, PDGFRA, NGFR, NTRK3, NTRK2, NTRK1
36	Cellular Apoptosis Pathway36	7.3	NTRK1, NTRK2, NTRK3, NGFR, PDGFRA, TGFB2
37	Pathways in cancer20	7.2	STAT3, KRAS, PDGFRA, SMO, NTRK1, PTEN
38	ILK Signaling36	6.9	KRT18, TGFB2, KIT, KITLG, VIM, BMP2
39	DHA Signaling36	6.8	CASP3, AKT3, NTF3, NTRK1, NTRK2, NTRK3
40	GPCR Pathway36	6.8	NTF3, KIT, KITLG, TGFB2, PDGFRA, NTRK3
41	p38 Signaling36	6.7	NTF3, IGF1, CSF3, IGF1R, TGFB2, PDGFRA
42	Molecular Mechanisms of Cancer36	6.7	KITLG, CASP3, TP53, PTEN, NTF3, NTRK2
43	Renin-Angiotensin Pathway36	6.6	NTF3, NTRK1, STAT3, IGF1, IGF1R, MAPK10
44	Estrogen Pathway36	6.5	KIT, MAPK3, NTRK1, BCL2, KDR, RAF1
45	PAK Pathway36	6.5	BCL2, IL1A, IL1B, MAPK10, IGF1R, IGF1
46	Antioxidant Action of Vitamin-C36	6.2	MAPK10, KIT, KITLG, BMP2, CSF3, TNF
47	Rho Family GTPases36	6.1	IGF1R, IGF1, TNC, TNF, NTF3, NTRK1
48	JAK-STAT Pathway36	5.9	NTRK3, NTRK2, NTRK1, NTF3, KIT, KITLG
49	MAPK Signaling36	5.6	KIT, KITLG, MYC, MAPK3, MAPK10, IGF1R
50	Pancreatic Adenocarcinoma36	5.1	MDM2, CDK4, CDKN2A, CDKN1A, BCL2, KDR

Compounds related to primitive neuroectodermal tumor according to GeneDecks:

(show top 50)    (show all 320)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.2	NCAM1, KIT, MYCN, MAPK3, IFNB1
2	hematoxylin32	9.9	NCAM1, KIT, VIM, CHGA, MUC1, S100A1
3	roscovitine32	9.9	VIM, MAPK3, NGF, STAT3
4	h2o232	9.6	KITLG, VIP, MYB, IRS1, IL1RAPL2, IGF1R
5	glucose32	9.6	KIT, SERPINF1, VIPR1, SCG2, S100B, ATF1
6	gaba32 42	10.5	NCAM1, VIM, VIP, CHGA, S100B, GRP
7	gnrh32	9.5	NCAM1, KITLG, VIM, RAF1, SCG2, GRP
8	egcg32	9.4	RAF1, IL1A, MAPK3, MAPK10, KRT18, TGFB2
9	calcitriol32 42 9 18 9	13.4	KITLG, RB1, MYC, BMP2, CDKN1A, CDK4
10	arginine32	9.3	VIP, MYB, BMP2, CHGA, S100B, CDK4
11	histamine32 18	10.1	NCAM1, KIT, KITLG, VIM, VIP, RAF1
12	agar32	9.1	KITLG, RB1, VIM, MYCN, RASSF1, MUC1
13	acetylcholine32 9 18 9	12.1	NCAM1, VIM, VIP, RAF1, SCG2, CHGA
14	glycogen32 18	10.0	KIT, VIM, MYC, CHGA, S100A1, S100B
15	bromodeoxyuridine32	8.9	NCAM1, KITLG, RB1, VIM, MYC, MYCN
16	adenylate32	8.8	KITLG, VIM, VIP, VIPR1, VIPR2, MYB
17	mg 13232 42	9.7	MYC, MYCN, KDR, CDKN1A, CDKN2A, IRS1
18	cyclic amp32 18	9.7	RB1, SCG2, CHGA, ATF1, CDKN2A, CDK4
19	cysteine32	8.6	SERPINF1, MYB, RAF1, KDR, SCG2, MUC1
20	dopamine32 9 18 9	11.6	NCAM1, VIP, MYCN, BMP2, RAF1, SCG2
21	etoposide32 42 9 9	11.5	RB1, MYC, MYCN, BCL2, CHGA, S100B
22	n acetylcysteine32	8.5	RAF1, KDR, CDKN1A, CDKN2A, CDK4, IRS1
23	cyclosporin a32 42	9.4	KITLG, VIP, MYC, MYB, BMP2, RAF1
24	12-o-tetradecanoylphorbol 13-acetate32	8.4	NCAM1, RB1, MYC, RAF1, SCG2, ATF1
25	glutamate32	8.4	NCAM1, SERPINF1, VIM, VIP, KDR, MSH2
26	cytarabine32 34 9 9	11.3	KIT, KITLG, RB1, VIM, MYC, BCL2
27	norepinephrine32 9 18 9	11.2	KITLG, VIP, SCG2, CHGB, CHGA, S100B
28	doxorubicin32 34 9 9	11.2	NCAM1, KIT, KITLG, VIM, MYCN, MYB
29	carboplatin32 34 9 9	11.2	KITLG, RB1, KDR, BCL2, CHGA, MSH2
30	phosphotyrosine32	8.1	KIT, RAF1, KDR, CDK4, IRS1, MAPK3
31	glutamine32	8.1	NCAM1, KIT, VIM, VIP, MYB, RAF1
32	alanine32	8.1	NCAM1, KITLG, VIP, VIPR1, MYC, MYB
33	adriamycin32	7.9	RB1, VIM, MYC, MYCN, BCL2, MUC1
34	matrigel32	7.7	NCAM1, RB1, SERPINF1, VIM, BMP2, KDR
35	docetaxel32 34 9 9	10.4	KIT, MYC, RAF1, KDR, BCL2, CDKN1A
36	calcium32 9 18 9	10.3	KIT, KITLG, RB1, SERPINF1, VIP, VIPR1
37	nitric oxide32 9 18 9	10.0	NCAM1, KIT, KITLG, RB1, SERPINF1, VIPR1
38	forskolin32 42 9 9	9.9	VIM, VIP, VIPR1, BMP2, RAF1, SCG2
39	butyrate32	6.8	KITLG, RB1, VIM, MYC, MYB, RAF1
40	5fluorouracil32	6.8	KIT, KITLG, RB1, KDR, BCL2, MUC1
41	estrogen32	6.7	VIP, BMP2, RAF1, RASSF1, KDR, CHGB
42	oxygen32 18	7.4	KITLG, RB1, SERPINF1, MYB, BMP2, BCL2
43	paclitaxel32 34 9 9	9.1	KIT, KITLG, RB1, VIM, MYC, RAF1
44	curcumin32	6.0	MYC, RAF1, BCL2, CDKN1A, CDK4, IL1A
45	cisplatin32 34 9 9	8.8	KITLG, RB1, MYC, MYCN, RAF1, RASSF1
46	wortmannin32 42	6.8	KITLG, VIM, BMP2, RAF1, KDR, BCL2
47	actinomycin d32	4.7	KIT, KITLG, RB1, VIM, VIPR1, MYC
48	genistein32 9 18 9	7.1	KITLG, RB1, VIM, MYC, MYCN, BMP2
49	dexamethasone32 42 34 9 9	8.1	NCAM1, KITLG, RB1, SERPINF1, VIM, VIP
50	retinoic acid32 42 18	6.0	NCAM1, KIT, KITLG, RB1, SERPINF1, VIPR1

Cellular components related to primitive neuroectodermal tumor according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear body	GO:016604	10.3	MYC, CDKN2A, MDM2, TP53
2	intermediate filament	GO:005882	10.3	NES, DES, SYNM, GFAP, KRT18, KRT8
3	protein complex	GO:043234	9.4	SYP, PTGS2, TP53, MDM2, CDKN2A, S100A1
4	caveola	GO:005901	9.2	SMO, PTGS2, PTCH1, MAPK3, IRS1
5	extracellular space	GO:005615	8.5	TNC, TNF, SPARC, COLQ, NGF, TGFB2
6	nucleoplasm	GO:005654	7.8	TP53, SMARCA5, SMARCB1, NOTCH1, NGFR, WT1
7	extracellular region	GO:005576	7.8	DMBT1, TNC, IFNB1, IGF1, IGLC7, SPARC
8	plasma membrane	GO:005886	6.8	NTF3, SSTR2, PTPRC, PTEN, PTCH1, TNF
9	cytoplasm	GO:005737	5.8	PDGFRA, SSTR2, DMBT1, PTGS2, PTEN, TP53
10	cytosol	GO:005829	5.6	CADPS, CASP3, TP53, PTEN, DICER1, DDC
11	nucleus	GO:005634	4.3	NEUROG2, SMARCA5, SMARCA4, SPARC, SS18, PTGS2

Biological processes related to primitive neuroectodermal tumor according to GeneDecks:

(show top 50)    (show all 69)

id	Name	GO ID	Score	Top Affiliating Genes
1	axonogenesis	GO:007409	10.6	SLITRK4, SLITRK1, SLITRK5, SLITRK3, SLITRK2, SLITRK6
2	positive regulation of neuron differentiation	GO:045666	10.4	NEUROG2, NEUROG1, NEUROD2, NEUROD1, ASCL1, BMP2
3	response to wounding	GO:009611	10.4	TGFB2, GFAP, NGFR, SMO, TNC, CASP3
4	chromatin remodeling	GO:006338	10.2	SMARCB1, SMARCA5, SMARCA4, MYB, MYC, RB1
5	positive regulation of fibroblast proliferation	GO:048146	10.1	PDGFRA, NGFR, IGF1, CDK4, CDKN1A, MYC
6	mechanoreceptor differentiation	GO:042490	10.1	NTRK2, NTRK1, NTF3
7	cell fate commitment	GO:045165	10.0	NEUROG2, NEUROG1, CASP3, KDR, BMP2
8	cell cycle arrest	GO:007050	9.9	TGFB2, TP53, APC, CDKN2A, CDKN1A, MSH2
9	positive regulation of DNA replication	GO:045740	9.8	PDGFRA, IGF1, IGF1R, ATF1, KITLG
10	phosphatidylinositol-mediated signaling	GO:048015	9.8	PDGFRA, NGF, NTRK1, PTEN, IGF1, IGF1R
11	inner ear development	GO:048839	9.8	NEUROD1, TGFB2, SPARC, IGF1, BMP2
12	negative regulation of cyclin-dependent protein kinase activity	GO:045736	9.7	CASP3, APC, CDKN2A, CDKN1A
13	protein destabilization	GO:031648	9.7	ID1, MDM2, CDKN2A, BMP2
14	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.7	NEUROD1, NEUROD2, NEUROG1, NEUROG2, NGF, SMARCB1
15	response to radiation	GO:009314	9.6	TGFB2, KRT13, NGF, BCL2, KIT
16	positive regulation of gene expression	GO:010628	9.6	TGFB2, KRAS, NGF, SMO, NTRK2, BMP2
17	organ morphogenesis	GO:009887	9.5	TH, PTCH1, TNF, ETV7, MAPK3, FLI1
18	heart development	GO:007507	9.5	TGFB2, TH, WT1, NOTCH1, SPARC, PTEN
19	negative regulation of transcription, DNA-dependent	GO:045892	9.5	WT1, NOTCH1, SMARCA4, TNF, TP53, ID1
20	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.5	TGFB2, PDGFRA, NTRK2, IGF1, KDR, KIT
21	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.4	DICER1, SMARCA4, SMO, NOTCH1, WT1, STAT3
22	positive regulation of cell migration	GO:030335	9.4	PDGFRA, NOTCH1, IGF1R, APC, IRS1, KDR
23	response to gamma radiation	GO:010332	9.4	PTPRC, TP53, IL1B, IL1A, BCL2, MYC
24	MAPK cascade	GO:000165	9.4	KRAS, TNF, MAPK3, IL1B, SCG2, RAF1
25	memory	GO:007613	9.4	S100B, IL1B, PTGS2, NGF, TH
26	response to organic cyclic compound	GO:014070	9.3	STAT3, PTGS2, ENO2, IL1A, CDKN1A, ATF1
27	response to L-ascorbic acid	GO:033591	9.2	SPARC, IL1B, IL1A, BCL2
28	negative regulation of neuron apoptotic process	GO:043524	9.2	KRAS, NGF, NTRK2, NTRK1, NTF3, MSH2
29	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.1	PDGFRA, NTRK1, TNF, MAPK3, IL1B, IL1A
30	response to glucocorticoid stimulus	GO:051384	9.1	KRAS, NGF, SPARC, PTGS2, TNF, IL1B
31	axon guidance	GO:007411	9.1	NEUROG2, TGFB2, KRAS, NGFR, NTF3, PTPRC
32	virus-host interaction	GO:019048	9.1	STAT3, KRT18, KRT8, PDGFRA, SMARCB1, DMBT1
33	response to organic nitrogen	GO:010243	9.1	TGFB2, PTGS2, IL1B, IL1A, CDKN1A
34	positive regulation of apoptotic process	GO:043065	9.1	NEUROD1, TGFB2, PTPRC, PTGS2, TNF, TP53
35	response to DNA damage stimulus	GO:006974	9.0	TP53, CASP3, MAPK3, APC, CDKN1A, BCL2
36	cellular response to organic substance	GO:071310	8.9	BCL2, IL1B, CASP3, SYP
37	negative regulation of cell growth	GO:030308	8.9	TGFB2, WT1, SMARCA4, TP53, CDKN2A, CDKN1A
38	nerve growth factor receptor signaling pathway	GO:048011	8.7	STAT3, KRAS, NGFR, NGF, NTRK2, NTRK1
39	Ras protein signal transduction	GO:007265	8.7	KRAS, NGF, NTRK1, TP53, IGF1, MAPK3
40	cytokine-mediated signaling pathway	GO:019221	8.6	CSF3, STAT3, KRAS, IFNB1, MAPK3, IL1B
41	response to hypoxia	GO:001666	8.4	TGFB2, TH, TNF, IL1B, IL1A, BCL2
42	anti-apoptosis	GO:006916	8.4	NGFR, NGF, TNF, IGF1, IGF1R, IL1B
43	positive regulation of cell proliferation	GO:008284	8.4	PTEN, NTRK2, NOTCH1, NGF, PDGFRA, KRAS
44	positive regulation of transcription, DNA-dependent	GO:045893	8.1	TNF, SMARCA4, NOTCH1, WT1, TAF15, STAT3
45	response to drug	GO:042493	8.1	SS18, NGF, TGFB2, STAT3, NES, NEUROD1
46	apoptotic process	GO:006915	7.8	TP53, TNF, PTEN, DICER1, NGF, NGFR
47	negative regulation of apoptotic process	GO:043066	7.7	NEUROD1, ASCL1, CDKN1A, SCG2, BCL2, KDR
48	negative regulation of cell proliferation	GO:008285	7.4	TNF, PTEN, PTGS2, SSTR2, NTRK1, WT1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.4	NEUROG2, NEUROG1, NEUROD1, STAT3, IL1B, IL1A
50	signal transduction	GO:007165	7.4	IGF1R, IGF1, AKT3, ERG, TNC, SPARC

Molecular functions related to primitive neuroectodermal tumor according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	E-box binding	GO:070888	10.5	NEUROG2, NEUROG1, NEUROD2, NEUROD1, ASCL1, MYC
2	neurotrophin binding	GO:043121	10.2	NTRK3, NTRK2, NTRK1
3	nerve growth factor binding	GO:048406	10.1	NTF3, NTRK1, NGFR
4	p53 binding	GO:002039	10.0	SMARCB1, SMARCA4, MDM2, CDKN2A, MUC1
5	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.8	PDGFRA, NTRK3, NTRK1, KDR, KIT
6	cytokine activity	GO:005125	9.4	CSF3, TGFB2, TNF, IFNB1, IL1B, IL1A
7	identical protein binding	GO:042802	9.3	IGF1R, TP53, TNF, SYP, PRMT8, MDM2
8	protein kinase binding	GO:019901	9.2	STAT3, PTPRC, PTEN, TP53, CCNB3, APC
9	protein heterodimerization activity	GO:046982	9.1	NEUROD2, NEUROD1, PRMT8, TGFB2, TP53, ENO2
10	sequence-specific DNA binding transcription factor activity	GO:003700	9.1	ERG, TP53, NOTCH1, WT1, STAT3, SOX1
11	growth factor activity	GO:008083	8.9	CSF3, TGFB2, NGF, NTF3, IGF1, IL1B
12	sequence-specific DNA binding	GO:043565	8.7	NEUROD1, STAT3, WT1, ERG, ETV7, ETV4
13	protein homodimerization activity	GO:042803	8.3	PTGS2, NTRK1, NTRK2, PDGFRA, TGFB2, PRMT8
14	protein binding	GO:005515	2.4	NEUROD1, SMARCA5, SMARCA4, NTRK1, SPARC, SSTR2