MCID: PRC003
MIFTS: 51

Proctitis malady

Summaries for Proctitis

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. sexually transmitted pathogens (neisseria gonorrhoeae, chlamydia trachomatis, herpes simplex virus 1 and 2, treponema pallidum) and enteric pathogens (campylobacter, shigella, salmonella) are involved in the disease. symptoms are rectal discomfort and bleeding.

MalaCards: Proctitis, also known as proctitis nos, is related to ulcerative colitis and prostatitis. An important gene associated with Proctitis is LTF (lactotransferrin), and among its related pathways is Selenium Pathway. The drug mesalamine and the compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and cervix, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:63 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6 more...

Aliases & Classifications for Proctitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

proctitis 8 10 44 60
proctitis nos 8


External Ids:

Disease Ontology8 DOID:3127
MeSH34 D011349
NCIt39 C38011

Related Diseases for Proctitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Proctitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.0TNF, CRP, LTF
2prostatitis30.8LTF, KLK3
3prostate cancer30.7KLK3, ATM, CDH3, CYP2E1, FGF2
4herpes simplex30.4ATM
5crohn's disease30.3LTF, CRP, TNF
6inflammatory bowel disease30.3LCN2, TNF, CRP, MPO, LTF, EPX
7systemic lupus erythematosus30.0CRP
8hepatitis30.0CYP2E1, LTF, TF
9arthritis30.0TNF, CRP, MPO, LTF, FGF2
10gastritis29.8LTF
11diarrhea29.8LTF, CRP, APOLD1
12neutropenia29.8MPO, KLK3
13pancreatitis29.8CRP, MPO, LTF, CYP2E1
14colorectal cancer29.8APOLD1, PPIG, EDNRA, ATM, LTF, CDH3
15lymphogranuloma venereum10.6
16ulcerative proctitis10.3
17radiation proctitis10.3
18radiation cystitis10.2
19cystitis10.2
20rectal prolapse10.1
21constipation10.1
22meningitis10.1
23reactive arthritis10.0
24hemorrhoid10.0
25lupus erythematosus10.0
26pouchitis10.0LTF
27irritable bowel syndrome10.0LTF
28sinusitis10.0RNASE3
29collagenous colitis10.0RNASE3
30thromboembolism10.0ENTPD1
31cervical cancer10.0LTF
32bronchopulmonary dysplasia10.0RNASE3
33chronic rhinitis10.0RNASE3
34endocarditis10.0EPX
35stroke, ischemic10.0ENTPD1
36gingivitis10.0LTF
37gastric ulcer10.0FGF2
38acute myocardial infarction10.0CRP
39eosinophil peroxidase deficiency10.0EPX
40coronary heart disease10.0CRP
41protein-energy malnutrition10.0TF
42conjunctivitis10.0RNASE3
43epidural abscess10.0CRP
44bronchiolitis10.0RNASE3
45pemphigus10.0CDH3
46sickle cell disease10.0TF
47aortic aneurysm10.0CRP
48schistosomiasis10.0RNASE3
49alpha thalassemia10.0TF
50pyelonephritis10.0CRP

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to proctitis

Clinical Features for Proctitis

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Drugs & Therapeutics for Proctitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Proctitis

Drug clinical trials:

Search ClinicalTrials for Proctitis

Search NIH Clinical Center for Proctitis

Search CenterWatch for Proctitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Proctitis

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Anatomical Context for Proctitis

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32MalaCards
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MalaCards organs/tissues related to Proctitis:

32
Prostate, Colon, Cervix, Bone, Spleen, Skin, Monocytes, T cells, Endothelial

Animal Models for Proctitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Proctitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.8LCN2, TF, EDNRA, CRP, LTF, ENTPD1
2MP:00053878.4TNF, EDNRA, CRP, MPO, ATM, LTF
3MP:00053978.1ENTPD1, LCN2, TNF, TF, EDNRA, MPO

Publications for Proctitis

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Sources:
50PubMed
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Articles related to Proctitis:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
Protective role of antiplatelet treatment against ulcer formation due to argon plasma coagulation in patients treated for chronic radiation proctitis. (24138319)
2013
2
Hyperbaric oxygen treatment in radiation-induced cystitis and proctitis: a prospective cohort study on patient-perceived quality of recovery. (24035333)
2013
3
Successful treatment of radiation-induced proctitis pain by blockade of the ganglion impar in an elderly patient with prostate cancer: a case report. (23461840)
2013
4
Abdominal pain, constipation, and tenesmus in an adolescent female: consider Chlamydia proctitis. (23518359)
2013
5
Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man. (22465339)
2012
6
Can we decrease the acute proctitis in prostate cancer patients using hyaluronic acid during radiation therapy: a prospective historically controlled clinical study. (22774405)
2012
7
Long-term sequential changes of radiation proctitis and angiopathy in rats. (22510594)
2012
8
Hemorrhoid management in patients with radiation proctitis. (22714783)
2012
9
Rectal band ligation for treatment of extensive chronic hemorrhagic radiation proctitis. (23012030)
2012
10
Placebo controlled evaluation of Xilei San, a herbal preparation in patients with intractable ulcerative proctitis. (22775479)
2012
11
Radiation proctitis: current strategies in management. (22144997)
2011
12
Lymphogranuloma venereum in Zurich, Switzerland: Chlamydia trachomatis serovar L2 proctitis among men who have sex with men. (20131124)
2010
13
Clinical trial: a novel high-dose 1 g mesalamine suppository (Salofalk) once daily is as efficacious as a 500-mg suppository thrice daily in active ulcerative proctitis. (20310020)
2010
14
Efficacy and safety of single-session argon plasma coagulation in the management of chronic radiation proctitis. (20493484)
2010
15
Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial. (18952309)
2009
16
Be aware of proctitis and lymphogranuloma venereum. (19307169)
2009
17
Colonic explosion with use of argon plasma coagulation for radiation proctitis. (19907967)
2009
18
Sexually transmitted infections as a cause of proctitis in men who have sex with men. (19333054)
2009
19
Appendicectomy as a therapy for ulcerative proctitis. (19584834)
2009
20
Thalidomide effect in endothelial cell of acute radiation proctitis. (18720539)
2008
21
'Bleedin' difficult'--chronic radiation proctitis. (18061413)
2008
22
A prospective study of faecal calprotectin and lactoferrin in the monitoring of acute radiation proctitis in prostate cancer treatment. (18938774)
2008
23
Persistent high-risk sexual behaviour in men who have sex with men after symptomatic lymphogranuloma venereum proctitis. (17945053)
2007
24
Severe proctitis, perforation, and fatal rectal bleeding secondary to cytomegalovirus in an immunocompetent patient: report of a case. (17186350)
2007
25
A phase II study to evaluate WF10 in patients with late hemorrhagic radiation cystitis and proctitis. (16169580)
2006
26
Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis--an effective but not risk-free procedure: a prospective study of 33 patients. (15933799)
2005
27
Conservative therapies for hemorrhagic radiation proctitis: a review. (14666326)
2003
28
Effect of budesonide enema on remission and relapse rate in distal ulcerative colitis and proctitis. (12126250)
2002
29
Acute symptoms, not rectally administered sucralfate, predict for late radiation proctitis: longer term follow-up of a phase III trial--Trans-Tasman Radiation Oncology Group. (12243820)
2002
30
Complications following formalin installation in the treatment of radiation induced proctitis. (10855551)
2000
31
Is there more than one late radiation proctitis syndrome? (10386716)
1999
32
Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis. (9510317)
1998
33
Maintenance treatment of ulcerative proctitis with mesalazine suppositories: a double-blind placebo-controlled trial. The Italian IBD Study Group. (9625131)
1998
34
Efficacy and tolerance of mesalazine suppositories vs. hydrocortisone foam in proctitis. (9146772)
1997
35
Intrarectal formalin application, an effective treatment for grade III haemorrhagic radiation proctitis. (7480824)
1995
36
Formalin therapy for radiation proctitis. (7990213)
1994
37
Proctitis and proctosigmoiditis--a need to identify the extent of disease in epidemiological surveys. (8513990)
1993
38
Tripotassium dicitrato bismuthate enemas in the treatment of ulcerative proctitis. (2129645)
1990
39
5-Aminosalicylic acid suppositories in the maintenance of remission in idiopathic proctitis or proctosigmoiditis: a double-blind placebo-controlled clinical trial. (2202199)
1990
40
High doses of 5-aminosalicylic acid enemas in chronic radiation proctitis: comparison with betamethasone enemas. (2239891)
1990
41
Group A streptococcal proctitis and balanitis. (2186354)
1990
42
Proctitis associated with cytomegalovirus and HIV infection in a homosexual man. (2153900)
1990
43
YAG laser treatment for radiation proctitis. (2767395)
1989
44
Sucralfate enemas in the treatment of chronic postradiation proctitis. (2596467)
1989
45
A case report of a "necrotizing" entero-colo-proctitis in the adult. (3232145)
1988
46
Sodium cromoglycate in proctitis and ulcerative colitis. (6119135)
1982
47
Chlamydia trachomatis proctitis. (7290129)
1981
48
Evaluation of acute proctitis. (7392128)
1980
49
Lipid proctitis. (492253)
1979
50
Recurrent papulo-ulcerative proctitis; report of a case. (13612396)
1958

Genetic Variations for Proctitis

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Expression for genes affiliated with Proctitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for genes affiliated with Proctitis

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37NCBI BioSystems Database
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Pathways related to Proctitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MPO, CRP, TNF

Compounds for genes affiliated with Proctitis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Proctitis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1pge24410.7EPX
2estrogen4410.3KLK3, LTF, RNASE3
3endotoxin4410.2RNASE3, LTF, EDNRA
4hydrocortisone44 2 59 1113.2KLK3, LTF, FGF2
5tenidap44 2811.2TNF, LTF, CRP
6cyclophosphamide44 49 1112.1CRP, CYP2E1, TF
7thiocyanate44 2411.1LTF, MPO, EPX
8polysaccharide4410.0LCN2, KLK3, RNASE3
9erythromycin44 49 2 1113.0CYP2E1, LTF, PPIG
10cytochalasin b4410.0MPO, RNASE3, EPX, LTF
11zymosan4410.0RNASE3, TNF, LTF, MPO
12methacholine44 1110.9MPO, LTF, RNASE3, CRP
13diazepam44 49 28 1112.9LTF, CYP2E1, FGF2, PPIG
14vitamin a44 11 2411.8LCN2, FGF2, LTF, CYP2E1
158-isoprostane449.8TNF, TF, MPO, CRP
16budesonide44 49 1111.8TNF, MPO, LTF, EPX, RNASE3
17azelastine44 1110.8PPIG, CYP2E1, RNASE3
18vitamin b12449.8CRP, MPO, LTF, TF
19dapsone2 44 49 1112.8EPX, PPIG, MPO, CYP2E1
20mitoxantrone44 49 1111.7KLK3, CYP2E1, ATM, MPO
21betacarotene449.7KLK3, TF, CRP, CYP2E1
22theophylline44 28 11 2412.7CRP, RNASE3, PPIG, CYP2E1, EPX
23pentoxifylline44 1110.7CYP2E1, LTF, TNF, MPO
24antipyrine44 1110.7CYP2E1, PPIG, TF
25thalidomide44 49 59 1112.7FGF2, KLK3, TNF, CYP2E1
26neopterin449.7CRP, TNF, LCN2, LTF
27n-formylmethionyl-leucylphenylalanine449.6LCN2, MPO, LTF, TNF, RNASE3
28iron44 2410.6TF, ATM, EPX, EDNRA, LCN2, LTF
29h2o2449.5FGF2, CYP2E1, EPX, MPO, EDNRA, LTF
30formaldehyde44 2410.5CYP2E1, EDNRA, MPO, EPX, RNASE3, KLK3
31prostacyclin449.5ENTPD1, FGF2, TNF, TF, EDNRA, CRP
32leukotriene b444 59 2411.5MPO, LTF, LCN2, TNF, EPX, RNASE3
33ascorbic acid44 2410.5MPO, CRP, TF, LTF, CYP2E1, FGF2
34fmlp449.4MPO, LCN2, LTF, EPX, RNASE3, TNF
35fibrinogen449.4RNASE3, LCN2, LTF, TNF, TF, CRP
36latex449.4RNASE3, LTF, EDNRA, CRP
37clozapine44 28 49 1112.4MPO, CYP2E1, PPIG, CRP
38histamine44 28 2411.4TF, RNASE3, TNF, EPX, MPO, LTF
39cyclosporin a44 28 5911.4RNASE3, TNF, LTF, FGF2, EDNRA, TF
40n acetylcysteine449.3TNF, TF, CRP, MPO, ATM, LTF
41serine449.3FGF2, EPX, LTF, MPO, KLK3, TNF
42dexamethasone44 49 28 1112.2RNASE3, KLK3, PPIG, EDNRA, LTF, CYP2E1
43paraffin449.2TF, KLK3, MPO, CDH3, FGF2, LTF
44vegf448.9RNASE3, CRP, TF, EDNRA, MPO, TNF
45lactate448.8ATM, MPO, TF, TNF, KLK3, EPX
46creatinine448.8LCN2, TF, EDNRA, CRP, LTF, MPO
47nitric oxide44 11 2410.8RNASE3, TNF, LCN2, MPO, ENTPD1, EPX
48prednisolone44 28 1110.8RNASE3, TNF, EDNRA, TF, MPO, EPX
49lipid448.7ATM, TNF, EDNRA, CYP2E1, CRP, RNASE3
50tyrosine448.5CDH3, CD6, LCN2, EDNRA, ATM, RNASE3

GO Terms for genes affiliated with Proctitis

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16Gene Ontology
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Cellular components related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2RNASE3, FGF2, LTF, CRP, TF, APOLD1

Biological processes related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascadeGO:0703749.8FGF2, EDNRA, TNF
2negative regulation of lipid storageGO:0108889.7TNF, CRP
3response to hypoxiaGO:0016669.0ATM, CRP, EDNRA, APOLD1, TNF

Molecular functions related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.1LTF, TF

Products for genes affiliated with Proctitis

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Sources for Proctitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet