Aliases & Classifications for Proctitis

MalaCards integrated aliases for Proctitis:

Name: Proctitis 12 72 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3127
ICD10 32 K62.89
MeSH 41 D011349
NCIt 46 C38011
UMLS 69 C0033246

Summaries for Proctitis

Disease Ontology : 12 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding.

MalaCards based summary : Proctitis is related to radiation proctitis and ulcerative colitis, and has symptoms including rectal tenesmus An important gene associated with Proctitis is EPX (Eosinophil Peroxidase), and among its related pathways/superpathways are Selenium Micronutrient Network and Fluid shear stress and atherosclerosis. The drugs Tacrolimus and Sucralfate have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and neutrophil, and related phenotype is immune system.

Wikipedia : 72 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last... more...

Related Diseases for Proctitis

Diseases related to Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 radiation proctitis 32.6 ENTPD1 KDR LTF PECAM1 TNF
2 ulcerative colitis 30.8 CRP MPO TNF
3 collagenous colitis 29.8 EPX MPO RNASE3
4 gastroenteritis 29.7 CRP RNASE3 TNF
5 pneumonia 29.6 CRP MPO TNF
6 inflammatory bowel disease 29.3 CRP EPX LTF MPO TNF
7 ulcerative proctitis 12.5
8 eosinophilic granuloma 10.5 EPX RNASE3
9 inflammatory bowel disease 4 10.5 EPX RNASE3
10 conjunctival nevus 10.5 EPX RNASE3
11 eosinophil peroxidase deficiency 10.5 EPX MPO
12 colitis 10.5
13 eosinophilic gastroenteritis 10.5 EPX RNASE3
14 autoimmune inner ear disease 10.4 MPO TNF
15 urinary schistosomiasis 10.4 EPX RNASE3
16 chronic rhinitis 10.4 EPX MPO
17 maxillary sinusitis 10.4 MPO RNASE3
18 microscopic polyangiitis 10.4 MPO TNF
19 pollen allergy 10.4 EPX RNASE3
20 melancholia 10.4 CRP TNF
21 mononeuritis multiplex 10.4 CRP MPO
22 aortitis 10.4 CRP MPO
23 lymphogranuloma venereum 10.4
24 prostatitis 10.4
25 mediastinitis 10.4 CRP MPO
26 relapsing fever 10.4 CRP TNF
27 henoch-schoenlein purpura 10.4 MPO RNASE3
28 granulocytopenia 10.3 MPO TNF
29 central nervous system vasculitis 10.3 CRP TNF
30 rapidly progressive glomerulonephritis 10.3 CRP MPO
31 louse-borne relapsing fever 10.3 CRP TNF
32 chlamydia 10.3
33 tuberculous peritonitis 10.3 CRP TNF
34 chronic maxillary sinusitis 10.3 MPO RNASE3
35 hypersensitivity vasculitis 10.3 CRP MPO
36 pulmonary aspergilloma 10.3 CRP MPO
37 hemangioendothelioma 10.3 KDR PECAM1
38 diverticulitis 10.3 CRP TNF
39 kaposiform hemangioendothelioma 10.3 KDR PECAM1
40 hypersensitivity reaction type iii disease 10.3 CRP MPO
41 ischemic heart disease 10.3 CRP TNF
42 pulmonary vein stenosis 10.3 KDR PECAM1
43 capillary hemangioma 10.3 KDR PECAM1
44 bronchial disease 10.3 EPX RNASE3 TNF
45 streptococcal meningitis 10.3 CRP TNF
46 epithelioid hemangioendothelioma 10.3 KDR PECAM1
47 vernal conjunctivitis 10.3 EPX MPO RNASE3
48 bursitis 10.3 CRP KDR
49 cavernous hemangioma 10.2 KDR PECAM1
50 allergic rhinitis 10.2 EPX MPO RNASE3

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to Proctitis

Symptoms & Phenotypes for Proctitis

UMLS symptoms related to Proctitis:


rectal tenesmus

MGI Mouse Phenotypes related to Proctitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CRP ENTPD1 EPX KDR LTF MPO

Drugs & Therapeutics for Proctitis

Drugs for Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
2
Sucralfate Approved Phase 4 54182-58-0 0
3 Calcineurin Inhibitors Phase 4,Phase 2
4 Immunosuppressive Agents Phase 4,Phase 2
5 Antacids Phase 4
6 Anti-Ulcer Agents Phase 4
7 Gastrointestinal Agents Phase 4,Phase 2
8
Budesonide Approved Phase 3,Phase 2 51333-22-3 5281004 63006
9
Inulin Approved, Investigational, Nutraceutical Phase 3 9005-80-5 24763
10 Anti-Asthmatic Agents Phase 3,Phase 2
11 Anti-Inflammatory Agents Phase 3,Phase 2
12 Autonomic Agents Phase 3,Phase 2
13 Bronchodilator Agents Phase 3,Phase 2
14 glucocorticoids Phase 3,Phase 2
15 Hormone Antagonists Phase 3,Phase 2
16 Hormones Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Respiratory System Agents Phase 3,Phase 2
20 Analgesics Phase 3,Phase 2
21 Analgesics, Non-Narcotic Phase 3,Phase 2
22 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
23 Antirheumatic Agents Phase 3,Phase 2
24 Mesalamine Phase 3,Phase 2 89-57-6
25 Cola Nutraceutical Phase 3,Phase 2
26 Acidophilus Nutraceutical Phase 2, Phase 3
27
Bisacodyl Approved Phase 2 603-50-9
28
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
29
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
30
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
31
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
32
Curcumin Approved, Investigational Phase 2 458-37-7 969516
33
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741 24759
34 Orange Approved, Nutraceutical Phase 2
35
Epinephrine Approved, Vet_approved 51-43-4 5816
36 Racepinephrine Approved 329-65-7
37 Epinephryl borate
38 Anesthetics

Interventional clinical trials:

(show all 38)

# Name Status NCT ID Phase Drugs
1 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
2 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
3 CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Withdrawn NCT00756197 Phase 4
4 Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. Unknown status NCT01414517 Phase 3
5 The Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Completed NCT01349673 Phase 3 Budesonide Foam
6 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms Completed NCT01901042 Phase 2, Phase 3
7 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3 Budesonide;Placebo
8 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3 Budesonide;Placebo
9 Efficacy and Safety Study of MAX-002 Suppository Versus Placebo in Mild to Moderate Ulcerative Proctitis Terminated NCT01016262 Phase 3 MAX-002;Placebo;Canasa®
10 Clinical Trial With Mesalamine 1g Suppositories Terminated NCT01172444 Phase 3 Mesalamine;Canasa;Placebo
11 Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries Terminated NCT00134628 Phase 3
12 Safety, Tolerability, Biomarker and Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis Unknown status NCT01149707 Phase 2 PUR 0110 Rectal Enema 250 mg;PUR 0110 Rectal Enema 500 mg;PUR 0110 Rectal Enema 1000 mg;Placebo Enema
13 Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis Completed NCT01966783 Phase 2 Budesonide 2 mg suppository;Budesonide 4 mg suppository;Mesalazine 1 g suppository;Budesonide 2 mg suppository/Mesalazine 1 g suppository
14 Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis Completed NCT01837615 Phase 2
15 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
16 Ion Prostate Irradiation Completed NCT01641185 Phase 2
17 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2 cisplatin
18 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
19 Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease Recruiting NCT03077412 Phase 2 Filgotinib;Placebo to match filgotinib
20 Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT) Active, not recruiting NCT02724618 Phase 2 Curcumin;Placebo
21 Brachytherapy for Recurrent Prostate Cancer Active, not recruiting NCT01956058 Phase 2
22 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
23 Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2 budesonide;Placebo foam
24 Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome Withdrawn NCT00514982 Phase 2 Mesalamine;Infliximab;Corticosteroids;6-Mercaptopurine;Tacrolimus;Adalimumab
25 Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis Unknown status NCT02233933
26 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492
27 Evaluation of PillCam IBD Capsule Endoscopy System in Visualization of Lesions in the Colon Indicative of Ulcerative Colitis Disease Completed NCT02025777
28 Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment Completed NCT01684514
29 Quality of Life Study Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent Completed NCT02836379
30 Patients Overexposed for a Prostate Adenocarcinoma Completed NCT00773656
31 Feasibility of Online Adaptive Radiotherapy for Muscle Invasive Bladder Cancer Completed NCT01142102
32 Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis Recruiting NCT03259659
33 Effect of a Low Residue Diet in Comparison to the Dietetic Recommendations From the INCan in Cervical Cancer Patients Recruiting NCT03100409
34 Invasive Group A Streptococcus (GAS) Infection in Children: Bacterial Virulence Factors and Detection of Host Immunological and/or Genetic Factors of Predisposition to Infections Recruiting NCT02010294
35 Faecal Incontinence iNtervention Study Recruiting NCT02355834
36 Phenomics in Autoimmune and Inflammatory Diseases Recruiting NCT02466217
37 QUality of Life in pAtients With Mild to modeRate Active procTitis Treated by mesalaZine (Pentasa®) Active, not recruiting NCT02368743 mesalazine
38 Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study Not yet recruiting NCT03397901

Search NIH Clinical Center for Proctitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: proctitis

Genetic Tests for Proctitis

Anatomical Context for Proctitis

MalaCards organs/tissues related to Proctitis:

38
Prostate, Colon, Neutrophil, Endothelial, Cervix, Skin, Bone

Publications for Proctitis

Articles related to Proctitis:

(show top 50) (show all 616)
# Title Authors Year
1
Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo. ( 29080145 )
2018
2
A case of a rectal stricture related to ischemic proctitis following rupture of an aortic aneurysm. ( 29399616 )
2018
3
Mini-Fecal Microbiota Transplantation for Treatment of Clostridium difficile Proctitis Following Total Colectomy. ( 29020255 )
2018
4
Multi Matrix System Mesalazine Plus Rectal Mesalazine in the Treatment of Mild to Moderately Active Ulcerative Proctitis. ( 29339645 )
2018
5
Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository. ( 29393142 )
2018
6
The role of confocal laser endomicroscopy in assessing mucosal healing in patients with ulcerative proctitis. ( 29186737 )
2017
7
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
8
Expression of Vascular Endothelial Growth Factor (VEGF) and its Correlation with Clinical Symptoms and Endoscopic Findings in Patients with Chronic Radiation Proctitis. ( 28963746 )
2017
9
Efficacy of topical 5-aminosalicylate monotherapy in patients with ulcerative proctitis with skip inflammation. ( 29205498 )
2017
10
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. ( 28694461 )
2017
11
Co-infection by lymphogranuloma venereum and Haemophilus parainfluenzae during an episode of proctitis. ( 28196678 )
2017
12
Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis. ( 28922252 )
2017
13
Proctitis And Anusitis ( 28613642 )
2017
14
Ischemic Proctitis Presenting as Rectal Pain and Bloody Diarrhea with No Apparent Cause. ( 28761891 )
2017
15
Chlamydia trachomatis proctitis masquerading as carcinoma rectum: First case report from India. ( 28631649 )
2017
16
Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, in the Treatment for Left-Sided Ulcerative Colitis and Ulcerative Proctitis. ( 29207381 )
2017
17
Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis. ( 28286194 )
2017
18
Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. ( 28232224 )
2017
19
Editorial: does disease extension lead to disease progression in proctitis? ( 28621077 )
2017
20
Lymphoid follicular proctitis resembling rectal carcinoid tumor, confirmed by endoscopic resection. ( 28415161 )
2017
21
Two Cases of Neisseria meningitidis Proctitis in HIV-Positive Men Who Have Sex with Men. ( 28221124 )
2017
22
Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. ( 28618234 )
2017
23
Are patients in the IBD clinic at risk of proctitis secondary to sexually transmitted infections? ( 29067152 )
2017
24
Clinical and microbiological aspects of the use of Lactobacillus rhamnosus PL1 strains in proctological patients with symptoms of chronic proctitis. ( 28703111 )
2017
25
Endoscopic diode laser therapy for chronic radiation proctitis. ( 28895000 )
2017
26
Correlation between Disease Activity and Endorectal Ultrasound Findings of Chronic Radiation Proctitis. ( 28755790 )
2017
27
Lymphogranuloma Venereum Proctitis. ( 28365488 )
2017
28
Therapeutic requirements in active ulcerative proctitis: A single-centre study. ( 28666605 )
2017
29
Herpes Simplex Proctitis Mimicking Inflammatory Bowel Disease in a Teenaged Male. ( 28473937 )
2017
30
Efficacy and safety of argon plasma coagulation in the management of extensive chronic radiation proctitis after pelvic radiotherapy for cervical carcinoma. ( 28707144 )
2017
31
Proctitis 1 Week after Stereotactic Body Radiation Therapy for Prostate Cancer: Implications for Clinical Trial Design. ( 27489794 )
2016
32
Impact of treatment time-related factors on prognoses and radiation proctitis after definitive chemoradiotherapy for cervical cancer. ( 27416796 )
2016
33
Severe Proctitis Caused by Chlamydia trachomatis Serovars D. ( 27803429 )
2016
34
Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study. ( 27489240 )
2016
35
Purulent Proctitis Caused by Prevotella bivia in a Homosexual Male. ( 28008411 )
2016
36
Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development. ( 26925655 )
2016
37
Did L Strains Responsible for Lymphogranuloma Venereum Proctitis Spread Among People With Genital Chlamydia trachomatis Infection in France in 2013? ( 27200521 )
2016
38
MRI characteristics of proctitis in Crohn's disease on perianal MRI. ( 27315072 )
2016
39
Baseline Oral 5-ASA Use and Efficacy and Safety of Budesonide Foam in Patients with Ulcerative Proctitis and Ulcerative Proctosigmoiditis: Analysis of 2 Phase 3 Studies. ( 27416045 )
2016
40
Efficacy and safety of Yunxiangjing derived from Chinese herbal medicine administered as an enema in the management of acute radiation-induced proctitis in patients with pelvic malignancy. ( 26946618 )
2016
41
The contribution of Mycoplasma genitalium to the aetiology of sexually acquired infectious proctitis in men who have sex with men. ( 26686807 )
2016
42
Flagellin preconditioning enhances the efficacy of mesenchymal stem cells in an irradiation-induced proctitis model. ( 26992430 )
2016
43
Azathioprine for refractory ulcerative proctitis: A retrospective multicenter study. ( 28089625 )
2016
44
Chronic haemorrhagic radiation proctitis: A review. ( 27462390 )
2016
45
Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. ( 27446860 )
2016
46
Lymphogranuloma venereum proctitis. ( 27695183 )
2016
47
Colostomy is a simple and effective procedure for severe chronic radiation proctitis. ( 27350738 )
2016
48
Complication and remission rates after endoscopic argon plasma coagulation in the treatment of haemorrhagic radiation proctitis. ( 27527929 )
2016
49
Syphilitic proctitis. ( 27365889 )
2016
50
Long-term results on the efficacy of argon plasma coagulation for patients with chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy for prostate cancer. ( 27663931 )
2016

Variations for Proctitis

Expression for Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for Proctitis

GO Terms for Proctitis

Cellular components related to Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 CRP ENTPD1 EPX KLK3 LTF MPO
2 extracellular region GO:0005576 9.56 CRP EPX KDR KLK3 LTF MPO
3 membrane raft GO:0045121 9.43 KDR PECAM1 TNF
4 extracellular space GO:0005615 9.23 CRP EPX KLK3 LTF MPO PECAM1

Biological processes related to Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.63 KDR PECAM1 TNF
2 defense response GO:0006952 9.54 EPX MPO TNF
3 antibacterial humoral response GO:0019731 9.48 LTF RNASE3
4 innate immune response in mucosa GO:0002227 9.43 LTF RNASE3
5 defense response to Gram-positive bacterium GO:0050830 9.43 CRP RNASE3 TNF
6 hydrogen peroxide catabolic process GO:0042744 9.4 EPX MPO
7 negative regulation of growth of symbiont in host GO:0044130 9.32 MPO TNF
8 defense response to bacterium GO:0042742 9.26 LTF MPO RNASE3 TNF
9 negative regulation of lipid storage GO:0010888 9.16 CRP TNF
10 neutrophil degranulation GO:0043312 9.02 EPX LTF MPO PECAM1 RNASE3

Molecular functions related to Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 LTF RNASE3
2 peroxidase activity GO:0004601 8.96 EPX MPO
3 heme binding GO:0020037 8.8 CYP3A5 EPX MPO

Sources for Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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