MCID: PRC003
MIFTS: 43

Proctitis malady

Gastrointestinal diseases category
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Summaries for Proctitis

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Disease Ontology:8 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. sexually transmitted pathogens (neisseria gonorrhoeae, chlamydia trachomatis, herpes simplex virus 1 and 2, treponema pallidum) and enteric pathogens (campylobacter, shigella, salmonella) are involved in the disease. symptoms are rectal discomfort and bleeding.

MalaCards based summary: Proctitis, also known as proctitis nos, is related to colitis and ulcerative colitis. An important gene associated with Proctitis is LTF (lactotransferrin), and among its related pathways is Allograft rejection. The drug mesalamine and the compounds thiocyanate and zymosan have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and neutrophil.

Wikipedia:65 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6 more...

Aliases & Classifications for Proctitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
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Proctitis, Aliases & Descriptions:

Name: Proctitis 8 10 44 62
 
Proctitis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:3127
MeSH34 D011349
NCIt39 C38011

Related Diseases for Proctitis

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Graphical network of the top 20 diseases related to Proctitis:



Diseases related to proctitis

Symptoms for Proctitis

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Drugs & Therapeutics for Proctitis

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Drug clinical trials:

Search ClinicalTrials for Proctitis

Search NIH Clinical Center for Proctitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Proctitis

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Anatomical Context for Proctitis

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MalaCards organs/tissues related to Proctitis:

32
Prostate, Colon, Neutrophil, Cervix, Bone, Spleen, Skin, Monocytes, T cells, Endothelial

Animal Models for Proctitis or affiliated genes

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Publications for Proctitis

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Articles related to Proctitis:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Comparison of Xilei-san, a Chinese herbal medicine, and dexamethasone in mild/moderate ulcerative proctitis: a double-blind randomized clinical trial. (23383973)
2013
2
Can we decrease the acute proctitis in prostate cancer patients using hyaluronic acid during radiation therapy: a prospective historically controlled clinical study. (23690202)
2013
3
Protective role of antiplatelet treatment against ulcer formation due to argon plasma coagulation in patients treated for chronic radiation proctitis. (24138319)
2013
4
Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man. (22465339)
2012
5
Can we decrease the acute proctitis in prostate cancer patients using hyaluronic acid during radiation therapy: a prospective historically controlled clinical study. (22774405)
2012
6
Large-volume argon plasma coagulation in the management of chronic radiation proctitis. (21353865)
2011
7
Case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis, and hepatitis. (21998411)
2011
8
The effect of a flavonoid fractions diosmin + hesperidin on radiation-induced acute proctitis in a rat model. (21768702)
2011
9
Systemic lupus erythematosus presenting as ischaemic proctitis. (21300684)
2011
10
Cytomegalovirus proctitis: a rare and disregarded sexually transmitted disease. (21844745)
2011
11
A murine model for the study of molecular pathogenesis of radiation proctitis. (20005457)
2010
12
Efficacy and safety of mesalamine suppositories for treatment of ulcerative proctitis in children and adolescents. (20848454)
2010
13
Images in clinical medicine. Radiation proctitis. (20843251)
2010
14
Topically administered infliximab can work in ulcerative proctitis despite the ineffectiveness of intravenous induction therapy. (19436284)
2009
15
Pica-induced proctitis? (19506441)
2009
16
Diagnosing chlamydia and managing proctitis in men who have sex with men: current UK practice. (18077609)
2008
17
Images in HIV/AIDS. HIV-associated lymphogranuloma venereum proctitis. (17396331)
2007
18
Increase of hepcidin plasma and urine levels is associated with acute proctitis and changes in hemoglobin levels in primary radiotherapy for prostate cancer. (17393200)
2007
19
Application of 10 percent formalin for the treatment of radiation-induced hemorrhagic proctitis. (17080283)
2007
20
Histopathological comparison of topical therapy modalities for acute radiation proctitis in an experimental rat model. (16937473)
2006
21
Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis induces acute deterioration of mucosal blood flow. (16416079)
2006
22
Sucralfate does not ameliorate acute radiation proctitis: randomised study and meta-analysis. (16149294)
2005
23
Formalin dab for radiation proctitis--an effective day care procedure. (16114161)
2005
24
Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis--an effective but not risk-free procedure: a prospective study of 33 patients. (15933799)
2005
25
Efficacy and safety of argon plasma coagulation for the treatment of hemorrhagic radiation proctitis. (15584849)
2004
26
Ulcerative proctitis. (20011281)
2004
27
Review article: problematic proctitis and distal colitis. (15352902)
2004
28
Formaldehyde application for haemorrhagic radiation-induced proctitis: a clinical and histological study. (12780922)
2003
29
Ulcerating proctitis in a patient with congenital neutropenia. (12809854)
2003
30
Effect of budesonide enema on remission and relapse rate in distal ulcerative colitis and proctitis. (12126250)
2002
31
Diverting loop colostomy for the treatment of refractory gastrointestinal bleeding secondary to radiation proctitis. (11778411)
2001
32
A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis. (10811338)
2000
33
The natural history of ulcerative proctitis: a multicenter, retrospective study. Gruppo di Studio per le Malattie Infiammatorie Intestinali (GSMII). (10685752)
2000
34
Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy. (11072170)
2000
35
Cytomegalovirus proctitis in a diabetic. (9933671)
1999
36
Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial. (10378604)
1999
37
Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis. (9510317)
1998
38
The ileocecal reservoir for rectal replacement in complicated radiation proctitis. (8873525)
1996
39
Pharmacokinetics of budesonide enema in patients with distal ulcerative colitis or proctitis. (8218754)
1993
40
Aminophylline suppository-induced acute proctitis. (1615945)
1992
41
Proctitis cystica profunda in paraplegics. Report of three cases. (1473421)
1992
42
Preliminary results of a phase I/II study of sodium pentosanpolysulfate in the treatment of chronic radiation-induced proctitis. (1689537)
1990
43
Nonspecific ulcerative proctitis. (3298052)
1987
44
Ischaemic proctitis and adventitial fibromuscular dysplasia of the superior rectal artery. (6689966)
1984
45
Proctitis. (6853994)
1983
46
Confirmatory serodiagnosis of lymphogranuloma venereum proctitis may yield false-positive results due to other chlamydial infections of the rectum. (7221807)
1981
47
Campylobacter proctitis in a homosexual man. (7436170)
1980
48
Traumatic proctitis. (7394693)
1980
49
Effect of sulphapyridine, 5-aminosalicylic acid, and placebo in patients with idiopathic proctitis: a study to determine the active therapeutic moiety of sulphasalazine. (6107263)
1980
50
Ulcerative proctitis and mild ulcerative colitis: A study of 220 patients. (5975902)
1966

Variations for Proctitis

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Expression for genes affiliated with Proctitis

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Expression patterns in normal tissues for genes affiliated with Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for genes affiliated with Proctitis

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Pathways related to Proctitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1EPX, RNASE3

Compounds for genes affiliated with Proctitis

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Compounds related to Proctitis according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1thiocyanate44 2410.9LTF, EPX
2zymosan449.6LTF, RNASE3
3percoll449.6LTF, RNASE3
4tele-methylhistamine449.6EPX, RNASE3
5sodium cromoglycate449.6RNASE3, EPX
6lte4449.6RNASE3, EPX
7citric acid44 28 24 1112.6LTF, RNASE3
8cetirizine44 28 24 1112.6EPX, RNASE3
9sephadex449.6RNASE3, EPX
10methacholine44 50 1111.5RNASE3, LTF
11ketotifen44 1110.5EPX, RNASE3
12salmeterol44 50 28 1112.5EPX, RNASE3
13anti-fungal449.5LTF, RNASE3
14ltc4449.5EPX, RNASE3
15n-formylmethionyl-leucylphenylalanine449.5RNASE3, LTF
16salbutamol44 50 28 24 1113.5RNASE3, EPX
17capsaicin44 2810.5LTF, RNASE3
18p005449.5EPX, RNASE3
19pgd2449.5RNASE3, EPX
20latex449.4LTF, RNASE3
21allergens449.4RNASE3, EPX
22theophylline44 28 24 1112.4EPX, RNASE3
23dithiothreitol449.4EPX, RNASE3
24p002449.4RNASE3, EPX
25carbohydrates449.3RNASE3, LTF
26prednisolone44 28 1111.3EPX, RNASE3
27hyaluronic acid44 2410.3LTF, RNASE3
28prostacyclin449.3ENTPD1, LTF
29formaldehyde44 2410.2EPX, RNASE3
30endotoxin449.2LTF, RNASE3
31n acetylcysteine449.2LTF, RNASE3
32budesonide44 50 1111.1LTF, EPX, RNASE3
33cytochalasin b449.1LTF, EPX, RNASE3
34leukotriene b444 61 2411.1RNASE3, EPX, LTF
35fmlp449.1LTF, EPX, RNASE3
36histamine44 28 2411.1RNASE3, EPX, LTF
37pge2449.1LTF, EPX, RNASE3
38creatinine449.0LTF, EPX, RNASE3
39heparin44 28 24 1112.0LTF, EPX, RNASE3
40h2o2449.0LTF, EPX, RNASE3
41dexamethasone44 50 28 1112.0LTF, EPX, RNASE3
42adenylate448.9LTF, ENTPD1, RNASE3
43estrogen448.9LTF, CDH3, RNASE3
44nitric oxide44 24 1110.4RNASE3, EPX, ENTPD1, CDH3
45tyrosine448.4RNASE3, EPX, ENTPD1, CDH3
46calcium44 50 24 1111.3RNASE3, EPX, ENTPD1, CDH3
47lipid448.2ENTPD1, EPX, RNASE3

GO Terms for genes affiliated with Proctitis

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Products for genes affiliated with Proctitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Proctitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet