MCID: PRC003
MIFTS: 42

Proctitis malady

Gastrointestinal diseases category
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Summaries for Proctitis

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. sexually transmitted pathogens (neisseria gonorrhoeae, chlamydia trachomatis, herpes simplex virus 1 and 2, treponema pallidum) and enteric pathogens (campylobacter, shigella, salmonella) are involved in the disease. symptoms are rectal discomfort and bleeding.

MalaCards: Proctitis, also known as proctitis nos, is related to ulcerative colitis and inflammatory bowel disease. An important gene associated with Proctitis is LTF (lactotransferrin), and among its related pathways is Allograft rejection. The drug mesalamine and the compounds thiocyanate and zymosan have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and cervix.

Wikipedia:65 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6 more...

Aliases & Classifications for Proctitis

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

proctitis 8 10 45 62
proctitis nos 8


External Ids:

Disease Ontology8 DOID:3127
MeSH35 D011349
NCIt40 C38011

Related Diseases for Proctitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Proctitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.0RNASE3, EPX, LTF
2inflammatory bowel disease30.4EPX, LTF
3collagenous colitis30.0RNASE3
4radiation proctitis11.0
5ulcerative proctitis10.9
6lymphogranuloma venereum10.6
7prostatitis10.6
8blindness10.5
9prostate cancer10.5
10herpes simplex10.3
11crohn's disease10.3
12cystitis10.3
13radiation cystitis10.2
14rectal prolapse10.2
15constipation10.2
16meningitis10.2
17reactive arthritis10.1
18systemic lupus erythematosus10.1
19arthritis10.1
20hemorrhoid10.1
21hepatitis10.1
22lupus erythematosus10.1
23chronic rhinitis10.1RNASE3
24schistosomiasis10.0RNASE3
25pneumonia10.0EPX
26giant papillary conjunctivitis10.0LTF, RNASE3
27churg-strauss syndrome10.0LTF, RNASE3
28onchocerciasis10.0EPX, RNASE3
29asthma10.0EPX, RNASE3
30otitis media10.0LTF, RNASE3
31pulmonary eosinophilia10.0RNASE3, EPX
32bronchitis10.0RNASE3, LTF
33food allergy10.0EPX, RNASE3
34hypereosinophilic syndrome10.0RNASE3, EPX
35respiratory failure10.0RNASE3, EPX
36rhinitis10.0EPX, RNASE3
37atopy10.0RNASE3, EPX
38eosinophilia10.0EPX, RNASE3
39allergic rhinitis10.0EPX, RNASE3
40allergic asthma10.0RNASE3, EPX
41atopic dermatitis10.0RNASE3, EPX
42endometrial carcinoma10.0CDH3, LTF
43skin disease10.0CDH3, RNASE3
44psoriasis10.0LTF, CDH3, RNASE3
45cystic fibrosis9.9LTF, ENTPD1, RNASE3
46vulvovaginitis9.9
47pharyngitis9.9
48gastric antral vascular ectasia9.9
49gonorrhea9.9
50secondary syphilis9.9

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to proctitis

Symptoms for Proctitis

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Drugs & Therapeutics for Proctitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Proctitis

Search NIH Clinical Center for Proctitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Proctitis

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Anatomical Context for Proctitis

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33MalaCards
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MalaCards organs/tissues related to Proctitis:

33
Prostate, Colon, Cervix, Skin, Bone, Spleen, Monocytes, T cells, Endothelial

Animal Models for Proctitis or affiliated genes

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Publications for Proctitis

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52PubMed
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Articles related to Proctitis:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Comparison of Xilei-san, a Chinese herbal medicine, and dexamethasone in mild/moderate ulcerative proctitis: a double-blind randomized clinical trial. (23383973)
2013
2
Can we decrease the acute proctitis in prostate cancer patients using hyaluronic acid during radiation therapy: a prospective historically controlled clinical study. (23690202)
2013
3
Protective role of antiplatelet treatment against ulcer formation due to argon plasma coagulation in patients treated for chronic radiation proctitis. (24138319)
2013
4
Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man. (22465339)
2012
5
Can we decrease the acute proctitis in prostate cancer patients using hyaluronic acid during radiation therapy: a prospective historically controlled clinical study. (22774405)
2012
6
Large-volume argon plasma coagulation in the management of chronic radiation proctitis. (21353865)
2011
7
Case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis, and hepatitis. (21998411)
2011
8
The effect of a flavonoid fractions diosmin + hesperidin on radiation-induced acute proctitis in a rat model. (21768702)
2011
9
Systemic lupus erythematosus presenting as ischaemic proctitis. (21300684)
2011
10
Cytomegalovirus proctitis: a rare and disregarded sexually transmitted disease. (21844745)
2011
11
A murine model for the study of molecular pathogenesis of radiation proctitis. (20005457)
2010
12
Efficacy and safety of mesalamine suppositories for treatment of ulcerative proctitis in children and adolescents. (20848454)
2010
13
Images in clinical medicine. Radiation proctitis. (20843251)
2010
14
Topically administered infliximab can work in ulcerative proctitis despite the ineffectiveness of intravenous induction therapy. (19436284)
2009
15
Pica-induced proctitis? (19506441)
2009
16
Diagnosing chlamydia and managing proctitis in men who have sex with men: current UK practice. (18077609)
2008
17
Images in HIV/AIDS. HIV-associated lymphogranuloma venereum proctitis. (17396331)
2007
18
Increase of hepcidin plasma and urine levels is associated with acute proctitis and changes in hemoglobin levels in primary radiotherapy for prostate cancer. (17393200)
2007
19
Application of 10 percent formalin for the treatment of radiation-induced hemorrhagic proctitis. (17080283)
2007
20
Histopathological comparison of topical therapy modalities for acute radiation proctitis in an experimental rat model. (16937473)
2006
21
Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis induces acute deterioration of mucosal blood flow. (16416079)
2006
22
Sucralfate does not ameliorate acute radiation proctitis: randomised study and meta-analysis. (16149294)
2005
23
Formalin dab for radiation proctitis--an effective day care procedure. (16114161)
2005
24
Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis--an effective but not risk-free procedure: a prospective study of 33 patients. (15933799)
2005
25
Efficacy and safety of argon plasma coagulation for the treatment of hemorrhagic radiation proctitis. (15584849)
2004
26
Ulcerative proctitis. (20011281)
2004
27
Formaldehyde application for haemorrhagic radiation-induced proctitis: a clinical and histological study. (12780922)
2003
28
Ulcerating proctitis in a patient with congenital neutropenia. (12809854)
2003
29
Effect of budesonide enema on remission and relapse rate in distal ulcerative colitis and proctitis. (12126250)
2002
30
Diverting loop colostomy for the treatment of refractory gastrointestinal bleeding secondary to radiation proctitis. (11778411)
2001
31
Effective use of argon plasma coagulation in the treatment of severe radiation proctitis. (11742159)
2001
32
A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis. (10811338)
2000
33
The natural history of ulcerative proctitis: a multicenter, retrospective study. Gruppo di Studio per le Malattie Infiammatorie Intestinali (GSMII). (10685752)
2000
34
Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy. (11072170)
2000
35
Cytomegalovirus proctitis in a diabetic. (9933671)
1999
36
Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial. (10378604)
1999
37
Comparison of oral with rectal mesalazine in the treatment of ulcerative proctitis. (9510317)
1998
38
The ileocecal reservoir for rectal replacement in complicated radiation proctitis. (8873525)
1996
39
Pharmacokinetics of budesonide enema in patients with distal ulcerative colitis or proctitis. (8218754)
1993
40
Aminophylline suppository-induced acute proctitis. (1615945)
1992
41
Proctitis cystica profunda in paraplegics. Report of three cases. (1473421)
1992
42
Preliminary results of a phase I/II study of sodium pentosanpolysulfate in the treatment of chronic radiation-induced proctitis. (1689537)
1990
43
Nonspecific ulcerative proctitis. (3298052)
1987
44
Ischaemic proctitis and adventitial fibromuscular dysplasia of the superior rectal artery. (6689966)
1984
45
Proctitis. (6853994)
1983
46
Confirmatory serodiagnosis of lymphogranuloma venereum proctitis may yield false-positive results due to other chlamydial infections of the rectum. (7221807)
1981
47
Campylobacter proctitis in a homosexual man. (7436170)
1980
48
Traumatic proctitis. (7394693)
1980
49
Effect of sulphapyridine, 5-aminosalicylic acid, and placebo in patients with idiopathic proctitis: a study to determine the active therapeutic moiety of sulphasalazine. (6107263)
1980
50
Ulcerative proctitis and mild ulcerative colitis: A study of 220 patients. (5975902)
1966

Variations for Proctitis

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Expression for genes affiliated with Proctitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for genes affiliated with Proctitis

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN
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Pathways related to Proctitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1EPX, RNASE3

Compounds for genes affiliated with Proctitis

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Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Proctitis according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1thiocyanate45 2410.9LTF, EPX
2zymosan459.6LTF, RNASE3
3percoll459.6LTF, RNASE3
4tele-methylhistamine459.6EPX, RNASE3
5sodium cromoglycate459.6RNASE3, EPX
6lte4459.6RNASE3, EPX
7citric acid45 29 24 1112.6LTF, RNASE3
8cetirizine45 29 24 1112.6EPX, RNASE3
9sephadex459.6RNASE3, EPX
10methacholine45 51 1111.5RNASE3, LTF
11ketotifen45 1110.5EPX, RNASE3
12salmeterol45 51 29 1112.5EPX, RNASE3
13anti-fungal459.5LTF, RNASE3
14ltc4459.5EPX, RNASE3
15n-formylmethionyl-leucylphenylalanine459.5RNASE3, LTF
16salbutamol45 51 29 24 1113.5RNASE3, EPX
17capsaicin45 2910.5LTF, RNASE3
18p005459.5EPX, RNASE3
19pgd2459.5RNASE3, EPX
20latex459.4LTF, RNASE3
21allergens459.4RNASE3, EPX
22theophylline45 29 24 1112.4EPX, RNASE3
23dithiothreitol459.4EPX, RNASE3
24p002459.4RNASE3, EPX
25carbohydrates459.3RNASE3, LTF
26prednisolone45 29 1111.3EPX, RNASE3
27hyaluronic acid45 2410.3LTF, RNASE3
28prostacyclin459.3ENTPD1, LTF
29formaldehyde45 2410.2EPX, RNASE3
30endotoxin459.2LTF, RNASE3
31n acetylcysteine459.2LTF, RNASE3
32budesonide45 51 1111.1LTF, EPX, RNASE3
33cytochalasin b459.1LTF, EPX, RNASE3
34leukotriene b445 61 2411.1RNASE3, EPX, LTF
35fmlp459.1LTF, EPX, RNASE3
36histamine45 29 2411.1RNASE3, EPX, LTF
37pge2459.1LTF, EPX, RNASE3
38creatinine459.0LTF, EPX, RNASE3
39heparin45 29 24 1112.0LTF, EPX, RNASE3
40h2o2459.0LTF, EPX, RNASE3
41dexamethasone45 51 29 1112.0LTF, EPX, RNASE3
42adenylate458.9LTF, ENTPD1, RNASE3
43estrogen458.9LTF, CDH3, RNASE3
44nitric oxide45 24 1110.4RNASE3, EPX, ENTPD1, CDH3
45tyrosine458.4RNASE3, EPX, ENTPD1, CDH3
46calcium45 51 24 1111.3RNASE3, EPX, ENTPD1, CDH3
47lipid458.2ENTPD1, EPX, RNASE3

GO Terms for genes affiliated with Proctitis

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Products for genes affiliated with Proctitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Proctitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet