MCID: PRC003
MIFTS: 51

Proctitis malady

Summaries for Proctitis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. sexually transmitted pathogens (neisseria gonorrhoeae, chlamydia trachomatis, herpes simplex virus 1 and 2, treponema pallidum) and enteric pathogens (campylobacter, shigella, salmonella) are involved in the disease. symptoms are rectal discomfort and bleeding.

MalaCards: Proctitis, also known as proctitis nos, is related to ulcerative colitis and prostatitis. An important gene associated with Proctitis is LTF (lactotransferrin), and among its related pathways is Selenium Pathway. The drug mesalamine and the compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and cervix, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:63 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6 more...

Aliases & Classifications for Proctitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

proctitis 8 10 44 60
proctitis nos 8


External Ids:

Disease Ontology8 DOID:3127
MeSH34 D011349
NCIt39 C38011

Related Diseases for Proctitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Proctitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.0TNF, CRP, LTF
2prostatitis30.8LTF, KLK3
3prostate cancer30.7KLK3, ATM, CDH3, CYP2E1, FGF2
4herpes simplex30.4ATM
5crohn's disease30.3LTF, CRP, TNF
6inflammatory bowel disease30.3LCN2, TNF, CRP, MPO, LTF, EPX
7systemic lupus erythematosus30.0CRP
8hepatitis30.0CYP2E1, LTF, TF
9arthritis30.0TNF, CRP, MPO, LTF, FGF2
10gastritis29.8LTF
11diarrhea29.8LTF, CRP, APOLD1
12neutropenia29.8MPO, KLK3
13pancreatitis29.8CRP, MPO, LTF, CYP2E1
14colorectal cancer29.8APOLD1, PPIG, EDNRA, ATM, LTF, CDH3
15lymphogranuloma venereum10.6
16ulcerative proctitis10.3
17radiation proctitis10.3
18radiation cystitis10.2
19cystitis10.2
20rectal prolapse10.1
21constipation10.1
22meningitis10.1
23reactive arthritis10.0
24hemorrhoid10.0
25lupus erythematosus10.0
26pouchitis10.0LTF
27irritable bowel syndrome10.0LTF
28sinusitis10.0RNASE3
29collagenous colitis10.0RNASE3
30thromboembolism10.0ENTPD1
31cervical cancer10.0LTF
32bronchopulmonary dysplasia10.0RNASE3
33chronic rhinitis10.0RNASE3
34endocarditis10.0EPX
35stroke, ischemic10.0ENTPD1
36gingivitis10.0LTF
37gastric ulcer10.0FGF2
38acute myocardial infarction10.0CRP
39eosinophil peroxidase deficiency10.0EPX
40coronary heart disease10.0CRP
41protein-energy malnutrition10.0TF
42conjunctivitis10.0RNASE3
43epidural abscess10.0CRP
44bronchiolitis10.0RNASE3
45pemphigus10.0CDH3
46sickle cell disease10.0TF
47aortic aneurysm10.0CRP
48schistosomiasis10.0RNASE3
49alpha thalassemia10.0TF
50pyelonephritis10.0CRP

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to proctitis

Clinical Features for Proctitis

About this section

Drugs & Therapeutics for Proctitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Proctitis

Drug clinical trials:

Search ClinicalTrials for Proctitis

Search NIH Clinical Center for Proctitis

Search CenterWatch for Proctitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Proctitis

About this section

Anatomical Context for Proctitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Proctitis:

32
Prostate, Colon, Cervix, Bone, Spleen, Skin, Monocytes, T cells, Endothelial

Animal Models for Proctitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Proctitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.8LCN2, TF, EDNRA, CRP, LTF, ENTPD1
2MP:00053878.4TNF, EDNRA, CRP, MPO, ATM, LTF
3MP:00053978.1ENTPD1, LCN2, TNF, TF, EDNRA, MPO

Publications for Proctitis

About this section
Sources:
50PubMed
See all sources

Articles related to Proctitis:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
Proximal disease extension and related predicting factors in ulcerative proctitis. (24325564)
2014
2
Letter to the editor concerning: Hawkins M, Billingham R, Bastawrous A. Hemorrhoid management in patients with radiation proctitis. Int J Colorectal Dis. 2012 Jun 20. [Epub ahead of print]. (23011547)
2013
3
Hyperbaric oxygen therapy for radiation-induced cystitis and proctitis. (22440041)
2012
4
Possible risk factors associated with radiation proctitis or radiation cystitis in patients with cervical carcinoma after radiotherapy. (23464440)
2012
5
Case of secondary syphilis presenting with unusual complications: syphilitic proctitis, gastritis, and hepatitis. (21998411)
2011
6
The effect of a flavonoid fractions diosmin + hesperidin on radiation-induced acute proctitis in a rat model. (21768702)
2011
7
The value of Botox-A in acute radiation proctitis: results from a phase I/II study using a three-dimensional scoring system. (20656418)
2011
8
Chronic radiation proctitis: issues surrounding delayed bowel dysfunction post-pelvic radiotherapy and an update on medical treatment. (21180615)
2010
9
Crohn's proctitis: a distinct entity. (19714756)
2010
10
Lymphogranuloma venereum proctitis masquerading as inflammatory bowel disease in 12 homosexual men. (20345500)
2010
11
Pica-induced proctitis? (19506441)
2009
12
Reactive arthritis associated with L2b lymphogranuloma venereum proctitis. (19478106)
2009
13
Lymphogranuloma venerium proctitis in the setting of HIV: a case report and differential diagnosis. (19534601)
2009
14
Lymphogranuloma venereum proctitis in men who have sex with men is associated with anal enema use and high-risk behavior. (18091565)
2008
15
Argon plasma coagulation in chronic radiation proctitis: Postgate et al. (17661253)
2007
16
Bacteremia caused by Solobacterium moorei in a patient with acute proctitis and carcinoma of the cervix. (16891535)
2006
17
Management of ischemic proctitis with severe rectal haemorrhage: a case report. (16773699)
2006
18
Formalin dab for radiation proctitis--an effective day care procedure. (16114161)
2005
19
Lymphogranuloma venereum in the differential diagnosis of proctitis. (15655238)
2005
20
Argon plasma coagulation in the treatment of hemorrhagic radiation proctitis. (16547855)
2005
21
Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study. (12835883)
2003
22
Haemorrhagic radiation proctitis: endoscopic severity may be useful to guide therapy. (12677457)
2003
23
Proctitis and Sexually Transmissible Diseases of the Colon. (12744826)
2003
24
Pharmacotherapy for chronic hemorrhagic radiation proctitis. (12297939)
2002
25
Geotrichum proctitis after HIV postexposure prophylaxis. (12172101)
2002
26
Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy. (11072170)
2000
27
Necrotizing proctitis caused by Streptococcus pyogenes. (10908025)
2000
28
Treatment of radiation-induced proctitis with sucralfate enemas. (10630828)
1999
29
Proctitis cystica profunda--an unusual rectal mass with varied etio-pathogenesis. (9989182)
1999
30
Medical therapy of ulcerative proctitis and proctosigmoiditis, including refractory disease. (23282392)
1995
31
Group A beta haemolytic streptococcal proctitis in an HIV-positive man. (8031920)
1994
32
Radiation proctitis after prostate carcinoma therapy. (8114228)
1994
33
A simple and effective treatment for hemorrhagic radiation proctitis using formalin. (8425416)
1993
34
Proctitis and rectal stenosis induced by nonsteroidal antiinflammatory suppositories. (8228081)
1993
35
Razoxane for Crohn's colitis and non-specific proctitis. (1290734)
1992
36
A steroid enema, budesonide, lacking systemic effects for the treatment of distal ulcerative colitis or proctitis. (1736348)
1992
37
Radiation proctitis: therapy and prognosis. (1996006)
1991
38
Risk factors for extensive ulcerative colitis and ulcerative proctitis: a population based case-control study. (1773960)
1991
39
Severe hemorrhagic radiation proctitis advancing to gradual cessation with hyperbaric oxygen. (1995275)
1991
40
Mesalazine (5-aminosalicylic acid) suppositories in the treatment of ulcerative proctitis or distal proctosigmoiditis. A randomized controlled trial. (2204103)
1990
41
Eosinophilic proctitis with giant cells: a manifestation of cow's milk protein intolerance. (2388123)
1990
42
Oral acyclovir for treatment of first-episode herpes simplex virus proctitis. (3367455)
1988
43
Allergic proctitis and gastroenteritis in children. Clinical and mucosal biopsy features in 53 cases. (3953938)
1986
44
Proctitis cystica profunda and radiation fibrosis in the rectum of the female Wistar rat after X irradiation: a histopathological study. (7131133)
1982
45
Immunoglobulin E in non-specific proctitis and ulcerative colitis-studies with a monoclonal antibody. (7160552)
1982
46
Campylobacter proctitis in a homosexual man. (7436170)
1980
47
Relationship of proctitis and rectal capacity in Crohn's disease. (7380336)
1980
48
Nonspecific proctitis in association with irritable colon syndrome. (596432)
1977
49
Ulcerative proctitis. (5450640)
1970
50
Ulcerative proctitis: course and prognosis. (5944055)
1966

Genetic Variations for Proctitis

About this section

Expression for genes affiliated with Proctitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for genes affiliated with Proctitis

About this section
Sources:
37NCBI BioSystems Database
See all sources

Pathways related to Proctitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MPO, CRP, TNF

Compounds for genes affiliated with Proctitis

About this section
Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
See all sources

Compounds related to Proctitis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1pge24410.7EPX
2estrogen4410.3KLK3, LTF, RNASE3
3endotoxin4410.2RNASE3, LTF, EDNRA
4hydrocortisone44 2 59 1113.2KLK3, LTF, FGF2
5tenidap44 2811.2TNF, LTF, CRP
6cyclophosphamide44 49 1112.1CRP, CYP2E1, TF
7thiocyanate44 2411.1LTF, MPO, EPX
8polysaccharide4410.0LCN2, KLK3, RNASE3
9erythromycin44 49 2 1113.0CYP2E1, LTF, PPIG
10cytochalasin b4410.0MPO, RNASE3, EPX, LTF
11zymosan4410.0RNASE3, TNF, LTF, MPO
12methacholine44 1110.9MPO, LTF, RNASE3, CRP
13diazepam44 49 28 1112.9LTF, CYP2E1, FGF2, PPIG
14vitamin a44 11 2411.8LCN2, FGF2, LTF, CYP2E1
158-isoprostane449.8TNF, TF, MPO, CRP
16budesonide44 49 1111.8TNF, MPO, LTF, EPX, RNASE3
17azelastine44 1110.8PPIG, CYP2E1, RNASE3
18vitamin b12449.8CRP, MPO, LTF, TF
19dapsone2 44 49 1112.8EPX, PPIG, MPO, CYP2E1
20mitoxantrone44 49 1111.7KLK3, CYP2E1, ATM, MPO
21betacarotene449.7KLK3, TF, CRP, CYP2E1
22theophylline44 28 11 2412.7CRP, RNASE3, PPIG, CYP2E1, EPX
23pentoxifylline44 1110.7CYP2E1, LTF, TNF, MPO
24antipyrine44 1110.7CYP2E1, PPIG, TF
25thalidomide44 49 59 1112.7FGF2, KLK3, TNF, CYP2E1
26neopterin449.7CRP, TNF, LCN2, LTF
27n-formylmethionyl-leucylphenylalanine449.6LCN2, MPO, LTF, TNF, RNASE3
28iron44 2410.6TF, ATM, EPX, EDNRA, LCN2, LTF
29h2o2449.5FGF2, CYP2E1, EPX, MPO, EDNRA, LTF
30formaldehyde44 2410.5CYP2E1, EDNRA, MPO, EPX, RNASE3, KLK3
31prostacyclin449.5ENTPD1, FGF2, TNF, TF, EDNRA, CRP
32leukotriene b444 59 2411.5MPO, LTF, LCN2, TNF, EPX, RNASE3
33ascorbic acid44 2410.5MPO, CRP, TF, LTF, CYP2E1, FGF2
34fmlp449.4MPO, LCN2, LTF, EPX, RNASE3, TNF
35fibrinogen449.4RNASE3, LCN2, LTF, TNF, TF, CRP
36latex449.4RNASE3, LTF, EDNRA, CRP
37clozapine44 28 49 1112.4MPO, CYP2E1, PPIG, CRP
38histamine44 28 2411.4TF, RNASE3, TNF, EPX, MPO, LTF
39cyclosporin a44 28 5911.4RNASE3, TNF, LTF, FGF2, EDNRA, TF
40n acetylcysteine449.3TNF, TF, CRP, MPO, ATM, LTF
41serine449.3FGF2, EPX, LTF, MPO, KLK3, TNF
42dexamethasone44 49 28 1112.2RNASE3, KLK3, PPIG, EDNRA, LTF, CYP2E1
43paraffin449.2TF, KLK3, MPO, CDH3, FGF2, LTF
44vegf448.9RNASE3, CRP, TF, EDNRA, MPO, TNF
45lactate448.8ATM, MPO, TF, TNF, KLK3, EPX
46creatinine448.8LCN2, TF, EDNRA, CRP, LTF, MPO
47nitric oxide44 11 2410.8RNASE3, TNF, LCN2, MPO, ENTPD1, EPX
48prednisolone44 28 1110.8RNASE3, TNF, EDNRA, TF, MPO, EPX
49lipid448.7ATM, TNF, EDNRA, CYP2E1, CRP, RNASE3
50tyrosine448.5CDH3, CD6, LCN2, EDNRA, ATM, RNASE3

GO Terms for genes affiliated with Proctitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2RNASE3, FGF2, LTF, CRP, TF, APOLD1

Biological processes related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascadeGO:0703749.8FGF2, EDNRA, TNF
2negative regulation of lipid storageGO:0108889.7TNF, CRP
3response to hypoxiaGO:0016669.0ATM, CRP, EDNRA, APOLD1, TNF

Molecular functions related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.1LTF, TF

Products for genes affiliated with Proctitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Proctitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet