Aliases & Classifications for Proctitis

Aliases & Descriptions for Proctitis:

Name: Proctitis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3127
ICD10 33 K62.89
MeSH 42 D011349
NCIt 47 C38011
UMLS 69 C0033246

Summaries for Proctitis

Disease Ontology : 12 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding.

MalaCards based summary : Proctitis is related to collagenous colitis and radiation proctitis, and has symptoms including rectal tenesmus An important gene associated with Proctitis is EPX (Eosinophil Peroxidase), and among its related pathways/superpathways are Folate Metabolism and Overview of nanoparticle effects. The drugs Tacrolimus and Sucralfate have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and neutrophil, and related phenotype is immune system.

Wikipedia : 71 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6 inches... more...

Related Diseases for Proctitis

Diseases related to Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
id Related Disease Score Top Affiliating Genes
1 collagenous colitis 29.4 CRP MPO TNF
2 radiation proctitis 12.4
3 ulcerative proctitis 12.4
4 colitis 10.4
5 ulcerative colitis 10.3
6 unilateral multicystic dysplastic kidney 10.3 CRP TNF
7 swine influenza 10.3 CRP TNF
8 cataract 10.3 CRP TNF
9 prostatitis 10.3
10 mechanical lagophthalmos 10.3 CRP TNF
11 human immunodeficiency virus infectious disease 10.3 CRP TNF
12 lymphogranuloma venereum 10.3
13 inflammatory and toxic neuropathy 10.2 CRP EPX
14 handl syndrome 10.2 LTF TNF
15 central epithelioid sarcoma 10.2 CRP TNF
16 joint disorders 10.2 CRP TNF
17 right ventricle hypoplasia 10.2 LTF TNF
18 prostate cancer 10.2
19 hole retinal cyst 10.2 KDR KLK3
20 chlamydia 10.2
21 autosomal dominant charcot-marie-tooth disease type 2 with giant axons 10.2 MPO TNF
22 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 LTF TNF
23 mirizzi syndrome 10.2 MPO TNF
24 hypochondriasis 10.2 KLK3 TNF
25 cicatricial lagophthalmos 10.2 CRP TNF
26 cannabis dependence 10.2 CRP MPO
27 fallopian tube adenomatoid tumor 10.2 CRP MPO
28 amelogenesis imperfecta 1j 10.2 EPX RNASE3
29 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 MPO TNF
30 parapharyngeal meningioma 10.1 CRP MPO
31 mikulicz disease 10.1 LTF TNF
32 spastic paraplegia 3a, autosomal dominant 10.1 EPX RNASE3
33 membranoproliferative glomerulonephritis 10.1 CRP LTF TNF
34 tuberculous salpingitis 10.1 CRP MPO
35 necrotizing gastritis 10.1 EPX RNASE3
36 subacute glomerulonephritis 10.1 CRP MPO
37 uveitis 10.1 MPO TNF
38 asbestosis 10.1 CRP EPX TNF
39 appendix carcinoid tumor 10.1 EPX RNASE3
40 epidermoid brain tumor 10.1 EPX MPO
41 parkinson disease 11 10.1 MPO TNF
42 acute gonococcal prostatitis 10.1 EPX RNASE3
43 bile duct signet ring cell carcinoma 10.1 CRP RNASE3 TNF
44 cyclotropia 10.1 CRP MPO
45 retinitis pigmentosa 51 10.1 CRP RNASE3 TNF
46 peritonitis 10.1 EPX MPO
47 calcinosis 10.1 CRP KLK3 TNF
48 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 LTF TNF
49 benign neonatal seizures 10.1 CRP TNF
50 vulvar disease 10.1 MPO RNASE3

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to Proctitis

Symptoms & Phenotypes for Proctitis

UMLS symptoms related to Proctitis:


rectal tenesmus

MGI Mouse Phenotypes related to Proctitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CRP ENTPD1 EPX KDR LTF MPO

Drugs & Therapeutics for Proctitis

Drugs for Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
2
Sucralfate Approved Phase 4 54182-58-0
3 Gastrointestinal Agents Phase 4,Phase 2
4 Antacids Phase 4
5 Immunosuppressive Agents Phase 4,Phase 2
6 Anti-Ulcer Agents Phase 4
7 Calcineurin Inhibitors Phase 4,Phase 2
8
Budesonide Approved Phase 3,Phase 2 51333-22-3 63006 5281004
9
Inulin Approved, Nutraceutical Phase 3 9005-80-5 24763
10 Mesalamine Phase 3,Phase 2 89-57-6
11 Analgesics Phase 3,Phase 2
12 glucocorticoids Phase 3,Phase 2
13 Analgesics, Non-Narcotic Phase 3,Phase 2
14 Hormone Antagonists Phase 3,Phase 2
15 Hormones Phase 3,Phase 2
16 Peripheral Nervous System Agents Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 Anti-Asthmatic Agents Phase 3,Phase 2
19 Anti-Inflammatory Agents Phase 3,Phase 2
20 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
21 Respiratory System Agents Phase 3,Phase 2
22 Antirheumatic Agents Phase 3,Phase 2
23 Autonomic Agents Phase 3,Phase 2
24 Bronchodilator Agents Phase 3,Phase 2
25 Acidophilus Nutraceutical Phase 2, Phase 3
26 Cola Nutraceutical Phase 3,Phase 2
27
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
28
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
29
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
31
Bisacodyl Approved Phase 2 603-50-9
32
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741 24759
33
Curcumin Phase 2 458-37-7 969516
34 Orange Nutraceutical Phase 2
35
Epinephrine Approved, Vet_approved 51-43-4 5816
36 Epinephryl borate
37 Racepinephrine

Interventional clinical trials:

(show all 35)
id Name Status NCT ID Phase
1 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4
2 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4
3 CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Withdrawn NCT00756197 Phase 4
4 Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. Unknown status NCT01414517 Phase 3
5 The Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Completed NCT01349673 Phase 3
6 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms Completed NCT01901042 Phase 2, Phase 3
7 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3
8 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3
9 Efficacy and Safety Study of MAX-002 Suppository Versus Placebo in Mild to Moderate Ulcerative Proctitis Terminated NCT01016262 Phase 3
10 Clinical Trial With Mesalamine 1g Suppositories Terminated NCT01172444 Phase 3
11 Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries Terminated NCT00134628 Phase 3
12 Safety, Tolerability, Biomarker and Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis Unknown status NCT01149707 Phase 2
13 Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis Completed NCT01966783 Phase 2
14 Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis Completed NCT01837615 Phase 2
15 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
16 Ion Prostate Irradiation Completed NCT01641185 Phase 2
17 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2
18 Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease Recruiting NCT03077412 Phase 2
19 Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT) Active, not recruiting NCT02724618 Phase 2
20 Brachytherapy for Recurrent Prostate Cancer Active, not recruiting NCT01956058 Phase 2
21 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
22 Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2
23 Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome Withdrawn NCT00514982 Phase 2
24 Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis Unknown status NCT02233933
25 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492
26 Evaluation of PillCam IBD Capsule Endoscopy System in Visualization of Lesions in the Colon Indicative of Ulcerative Colitis Disease Completed NCT02025777
27 Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment Completed NCT01684514
28 Patients Overexposed for a Prostate Adenocarcinoma Completed NCT00773656
29 Feasibility of Online Adaptive Radiotherapy for Muscle Invasive Bladder Cancer Completed NCT01142102
30 Quality of Life Study in Patients With Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent Recruiting NCT02836379
31 Effect of a Low Residue Diet in Comparison to the Dietetic Recommendations From the INCan in Cervical Cancer Patients Recruiting NCT03100409
32 Invasive Group A Streptococcus (GAS) Infection in Children: Bacterial Virulence Factors and Detection of Host Immunological and/or Genetic Factors of Predisposition to Infections Recruiting NCT02010294
33 Faecal Incontinence iNtervention Study Recruiting NCT02355834
34 Phenomics in Autoimmune and Inflammatory Diseases Recruiting NCT02466217
35 QUality of Life in pAtients With Mild to modeRate Active procTitis Treated by mesalaZine (Pentasa®) Active, not recruiting NCT02368743

Search NIH Clinical Center for Proctitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: proctitis

Genetic Tests for Proctitis

Anatomical Context for Proctitis

MalaCards organs/tissues related to Proctitis:

39
Prostate, Colon, Neutrophil, Endothelial, Cervix, Bone, Skin

Publications for Proctitis

Articles related to Proctitis:

(show top 50) (show all 586)
id Title Authors Year
1
Colostomy is a simple and effective procedure for severe chronic radiation proctitis. ( 27350738 )
2016
2
Azathioprine for refractory ulcerative proctitis: A retrospective multicenter study. ( 28089625 )
2016
3
Proctitis 1 Week after Stereotactic Body Radiation Therapy for Prostate Cancer: Implications for Clinical Trial Design. ( 27489794 )
2016
4
Efficacy and safety of Yunxiangjing derived from Chinese herbal medicine administered as an enema in the management of acute radiation-induced proctitis in patients with pelvic malignancy. ( 26946618 )
2016
5
Severe Proctitis Caused by Chlamydia trachomatis Serovars D. ( 27803429 )
2016
6
Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development. ( 26925655 )
2016
7
Did L Strains Responsible for Lymphogranuloma Venereum Proctitis Spread Among People With Genital Chlamydia trachomatis Infection in France in 2013? ( 27200521 )
2016
8
Clinical pattern and progression of ulcerative proctitis in the Japanese population: a retrospective study of incidence and risk factors influencing progression. ( 26663677 )
2016
9
MRI characteristics of proctitis in Crohn's disease on perianal MRI. ( 27315072 )
2016
10
Purulent Proctitis Caused by Prevotella bivia in a Homosexual Male. ( 28008411 )
2016
11
Complication and remission rates after endoscopic argon plasma coagulation in the treatment of haemorrhagic radiation proctitis. ( 27527929 )
2016
12
Exploring the Management of Radiation Proctitis in Current Clinical Practice. ( 27504391 )
2016
13
Impact of treatment time-related factors on prognoses and radiation proctitis after definitive chemoradiotherapy for cervical cancer. ( 27416796 )
2016
14
Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study. ( 27489240 )
2016
15
Chronic haemorrhagic radiation proctitis: A review. ( 27462390 )
2016
16
Long-term results on the efficacy of argon plasma coagulation for patients with chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy for prostate cancer. ( 27663931 )
2016
17
Lymphogranuloma venereum proctitis. ( 27695183 )
2016
18
Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. ( 27446860 )
2016
19
The contribution of Mycoplasma genitalium to the aetiology of sexually acquired infectious proctitis in men who have sex with men. ( 26686807 )
2016
20
Syphilitic proctitis. ( 27365889 )
2016
21
Baseline Oral 5-ASA Use and Efficacy and Safety of Budesonide Foam in Patients with Ulcerative Proctitis and Ulcerative Proctosigmoiditis: Analysis of 2 Phase 3 Studies. ( 27416045 )
2016
22
Flagellin preconditioning enhances the efficacy of mesenchymal stem cells in an irradiation-induced proctitis model. ( 26992430 )
2016
23
Chlamydial Proctitis in a Young Man Who Has Sex with Men: Misdiagnosed as Inflammatory Bowel Disease. ( 26730366 )
2015
24
P587. Tacrolimus suppositories in therapy-resistant ulcerative proctitis - a single center experience. ( 25718087 )
2015
25
P461. Therapeutic requirements and health resources in the treatment of clinically active ulcerative proctitis. ( 25717954 )
2015
26
Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis? ( 26547382 )
2015
27
Minimally invasive treatment of radiation proctitis and piles - a video vignette. ( 26382829 )
2015
28
Improvement of Refractory Ulcerative Proctitis With Sacral Nerve Stimulation. ( 25930972 )
2015
29
Proctitis cystica profunda diagnosed by endoscopic submucosal dissection: use of a therapeutic procedure for diagnosis. ( 26099078 )
2015
30
Severe distal ischemic proctitis with venous congestion following anterior resection for sigmoid colon cancer: the importance of Sudeck's point. ( 26346928 )
2015
31
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis. ( 26185013 )
2015
32
The Efficacy of Probiotic (Lactobacillus rhamnosus GG) and 5-ASA (Aminosalicylic Acid) in the Treatment of Experimental Radiation Proctitis in Rats. ( 26730065 )
2015
33
Osteopontin Knockout Does Not Influence the Severity of Rectal Damage in a Preclinical Model of Radiation Proctitis in Mice. ( 25577272 )
2015
34
The Painful Diversity of Proctitis in the Modern Era. ( 26736144 )
2015
35
Radiation Induced Cystitis and Proctitis - Prediction, Assessment and Management. ( 26320421 )
2015
36
Chronic radiation proctitis: tricks to prevent and treat. ( 26198994 )
2015
37
High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement? ( 26484355 )
2015
38
Dual-modal ablation treatment for refractory radiation proctitis. ( 26272198 )
2015
39
A case of appendectomy as main therapeutic intervention for complex co-morbid ulcerative proctitis. ( 25690705 )
2015
40
Effects of human amnion-derived mesenchymal stromal cell transplantation in rats with radiation proctitis. ( 26256683 )
2015
41
Sexually transmitted proctitis. ( 26034402 )
2015
42
Perianal Abscess and Proctitis by Klebsiella pneumoniae. ( 25691848 )
2015
43
P214. Ulcerative Proctitis: Predictors and outcomes of disease extension in UC. ( 25717682 )
2015
44
Budesonide foam induces remission in patients with mild to moderate ulcerative proctitis and ulcerative proctosigmoiditis. ( 25644096 )
2015
45
Sphincter-sparing intersphincteric rectal resection as an alternative to proctectomy in long-standing fistulizing and stenotic Crohn's proctitis? ( 25847822 )
2015
46
Formalin therapy for hemorrhagic radiation proctitis. ( 26398382 )
2015
47
Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients. ( 25890844 )
2015
48
Formalin irrigation for hemorrhagic chronic radiation proctitis. ( 25834325 )
2015
49
Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis. ( 26386854 )
2015
50
Proctitis after stapled hemorrhoidopexy is an underestimated complication of a widely used surgical procedure: a retrospective observational cohort study in 129 patients. ( 26561501 )
2015

Variations for Proctitis

Expression for Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for Proctitis

Pathways related to Proctitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 CRP MPO TNF
2 10.43 CRP TNF
3 10.16 MPO TNF
4 9.8 CYP3A5 MPO

GO Terms for Proctitis

Cellular components related to Proctitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 CRP ENTPD1 EPX KLK3 LTF MPO
2 extracellular region GO:0005576 9.56 CRP EPX KDR KLK3 LTF MPO
3 extracellular space GO:0005615 9.17 CRP EPX KLK3 LTF MPO RNASE3

Biological processes related to Proctitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.71 EPX LTF MPO RNASE3
2 defense response GO:0006952 9.5 EPX MPO TNF
3 negative regulation of viral genome replication GO:0045071 9.48 LTF TNF
4 antibacterial humoral response GO:0019731 9.46 LTF RNASE3
5 innate immune response in mucosa GO:0002227 9.43 LTF RNASE3
6 hydrogen peroxide catabolic process GO:0042744 9.37 EPX MPO
7 negative regulation of growth of symbiont in host GO:0044130 9.26 MPO TNF
8 negative regulation of lipid storage GO:0010888 9.16 CRP TNF
9 defense response to Gram-positive bacterium GO:0050830 9.13 CRP RNASE3 TNF
10 defense response to bacterium GO:0042742 8.92 LTF MPO RNASE3 TNF

Molecular functions related to Proctitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 EPX MPO
2 heme binding GO:0020037 8.8 CYP3A5 EPX MPO

Sources for Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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