MCID: PRC003
MIFTS: 51

Proctitis malady

Summaries for Proctitis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. sexually transmitted pathogens (neisseria gonorrhoeae, chlamydia trachomatis, herpes simplex virus 1 and 2, treponema pallidum) and enteric pathogens (campylobacter, shigella, salmonella) are involved in the disease. symptoms are rectal discomfort and bleeding.

MalaCards: Proctitis, also known as proctitis nos, is related to ulcerative colitis and prostatitis. An important gene associated with Proctitis is LTF (lactotransferrin), and among its related pathways is Selenium Pathway. The drug mesalamine and the compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and cervix, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:63 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6 more...

Aliases & Classifications for Proctitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

proctitis 8 10 44 60
proctitis nos 8


External Ids:

Disease Ontology8 DOID:3127
MeSH34 D011349
NCIt39 C38011

Related Diseases for Proctitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Proctitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.0TNF, CRP, LTF
2prostatitis30.8LTF, KLK3
3prostate cancer30.7KLK3, ATM, CDH3, CYP2E1, FGF2
4herpes simplex30.4ATM
5crohn's disease30.3LTF, CRP, TNF
6inflammatory bowel disease30.3LCN2, TNF, CRP, MPO, LTF, EPX
7systemic lupus erythematosus30.0CRP
8hepatitis30.0CYP2E1, LTF, TF
9arthritis30.0TNF, CRP, MPO, LTF, FGF2
10gastritis29.8LTF
11diarrhea29.8LTF, CRP, APOLD1
12neutropenia29.8MPO, KLK3
13pancreatitis29.8CRP, MPO, LTF, CYP2E1
14colorectal cancer29.8APOLD1, PPIG, EDNRA, ATM, LTF, CDH3
15lymphogranuloma venereum10.6
16ulcerative proctitis10.3
17radiation proctitis10.3
18radiation cystitis10.2
19cystitis10.2
20rectal prolapse10.1
21constipation10.1
22meningitis10.1
23reactive arthritis10.0
24hemorrhoid10.0
25lupus erythematosus10.0
26pouchitis10.0LTF
27irritable bowel syndrome10.0LTF
28sinusitis10.0RNASE3
29collagenous colitis10.0RNASE3
30thromboembolism10.0ENTPD1
31cervical cancer10.0LTF
32bronchopulmonary dysplasia10.0RNASE3
33chronic rhinitis10.0RNASE3
34endocarditis10.0EPX
35stroke, ischemic10.0ENTPD1
36gingivitis10.0LTF
37gastric ulcer10.0FGF2
38acute myocardial infarction10.0CRP
39eosinophil peroxidase deficiency10.0EPX
40coronary heart disease10.0CRP
41protein-energy malnutrition10.0TF
42conjunctivitis10.0RNASE3
43epidural abscess10.0CRP
44bronchiolitis10.0RNASE3
45pemphigus10.0CDH3
46sickle cell disease10.0TF
47aortic aneurysm10.0CRP
48schistosomiasis10.0RNASE3
49alpha thalassemia10.0TF
50pyelonephritis10.0CRP

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to proctitis

Clinical Features for Proctitis

About this section

Drugs & Therapeutics for Proctitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Proctitis

Drug clinical trials:

Search ClinicalTrials for Proctitis

Search NIH Clinical Center for Proctitis

Search CenterWatch for Proctitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Proctitis

About this section

Anatomical Context for Proctitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Proctitis:

32
Prostate, Colon, Cervix, Bone, Spleen, Skin, Monocytes, T cells, Endothelial

Animal Models for Proctitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Proctitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.8LCN2, TF, EDNRA, CRP, LTF, ENTPD1
2MP:00053878.4TNF, EDNRA, CRP, MPO, ATM, LTF
3MP:00053978.1ENTPD1, LCN2, TNF, TF, EDNRA, MPO

Publications for Proctitis

About this section
Sources:
50PubMed
See all sources

Articles related to Proctitis:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
Ischemic proctitis in a diabetic patient. (24261036)
2013
2
A rare cause of rectal bleeding masquerading as proctitis. (22739216)
2013
3
Early treatment and prevention of the radiation proctitis--composite enemas containing sodium butyrate. (23516076)
2013
4
Management of Radiation Proctitis. (23241500)
2013
5
Formalin for haemorrhagic radiation-induced proctitis. (21701806)
2012
6
A randomized controlled trial comparing colonic irrigation and oral antibiotics administration versus 4% formalin application for treatment of hemorrhagic radiation proctitis. (22965404)
2012
7
Lymphogranuloma venereum proctitis. (22459660)
2012
8
Systemic lupus erythematosus presenting as ischaemic proctitis. (21300684)
2011
9
The efficacy of the combination therapy with oral and topical mesalazine for patients with the first episode of radiation proctitis. (21365239)
2011
10
A multicenter, randomized study to evaluate the efficacy and safety of mesalamine suppositories 1 g at bedtime and 500 mg Twice daily in patients with active mild-to-moderate ulcerative proctitis. (20676771)
2011
11
Feasibility of radiofrequency ablation for the treatment of chronic radiation proctitis. (20504783)
2010
12
No prolonged effect of Ankaferd Blood Stopper on chronic radiation proctitis. (20931479)
2010
13
Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis. (19337853)
2009
14
Effective treatment of chronic radiation proctitis using radiofrequency ablation. (20593010)
2009
15
Emerging issues in ulcerative colitis and ulcerative proctitis: individualizing treatment to maximize outcomes. (20574506)
2009
16
Images in HIV/AIDS. HIV-associated lymphogranuloma venereum proctitis. (17396331)
2007
17
Increase of hepcidin plasma and urine levels is associated with acute proctitis and changes in hemoglobin levels in primary radiotherapy for prostate cancer. (17393200)
2007
18
Argon plasma coagulation in chronic radiation proctitis. (17427074)
2007
19
Formalin application for the treatment of radiation-induced hemorrhagic proctitis. (17326251)
2007
20
Sexually transmitted proctitis. (17099092)
2006
21
Endoluminal formalin application for haemorrhagic radiation proctitis. (16630241)
2006
22
Colorectal motor and sensitivity features in patients affected by ulcerative proctitis with constipation: a radiological and manometric controlled study. (16917226)
2006
23
Endoscopic and histopathologic findings after formalin application for hemorrhage caused by chronic radiation-induced proctitis. (15672081)
2005
24
Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis. (16170489)
2005
25
Granulocyte, macrophage, monocyte apheresis for refractory ulcerative proctitis. (15316424)
2004
26
Waiting-list induced proctitis: the hydrogen peroxide enema. (14679422)
2003
27
Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis. (12353856)
2002
28
Effective use of argon plasma coagulation in the treatment of severe radiation proctitis. (11742159)
2001
29
The natural history of ulcerative proctitis: a multicenter, retrospective study. Gruppo di Studio per le Malattie Infiammatorie Intestinali (GSMII). (10685752)
2000
30
The treatment of chronic radiation proctitis with hyperbaric oxygen in patients with prostate cancer. (10671898)
2000
31
Anti-inflammatory effect of rebamipide enema on proctitis type ulcerative colitis: a novel therapeutic alternative. (10925999)
2000
32
Radiation-induced Proctitis. (11096568)
1999
33
The beetle Anthrenus verbasci causing proctitis and perianal itching. (9754741)
1998
34
Short-chain fatty acids in the treatment of radiation proctitis: a randomized, double-blind, placebo-controlled, cross-over pilot trial. (9293933)
1997
35
Sucralfate and hydrocortisone enemas in the treatment of active ulcerative proctitis--a randomized single-blind comparative study. (8971294)
1996
36
Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis. (8792704)
1996
37
Newly recognized forms of colitis: collagenous colitis, microscopic (lymphocytic) colitis, and lymphoid follicular proctitis. (1925124)
1991
38
Comparison of beclomethasone dipropionate (2 and 3 mg) and prednisolone sodium phosphate enemas (30 mg) in the treatment of ulcerative proctitis. An adrenocortical approach. (2779692)
1989
39
Comparison of beclomethasone dipropionate and prednisolone 21-phosphate enemas in the treatment of ulcerative proctitis. (3047215)
1988
40
Alcohol-induced proctitis in a human. (3183332)
1988
41
Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates. (2446947)
1988
42
Argon laser treatment of hemorrhagic radiation proctitis. (3493941)
1987
43
Chlamydia trachomatis proctitis. (6546337)
1984
44
Ischaemic proctitis secondary to faecal impaction. (6633383)
1983
45
Proctitis and colitis following diversion of the fecal stream. (7450438)
1981
46
Traumatic proctitis. (7394693)
1980
47
Effect of sulphapyridine, 5-aminosalicylic acid, and placebo in patients with idiopathic proctitis: a study to determine the active therapeutic moiety of sulphasalazine. (6107263)
1980
48
Allergic proctitis, a clinical and immunopathological entity. (6780413)
1980
49
Gonococcal proctitis in a married woman. Report of a case. (144805)
1977
50
Ulcerative proctitis. (5450641)
1970

Genetic Variations for Proctitis

About this section

Expression for genes affiliated with Proctitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for genes affiliated with Proctitis

About this section
Sources:
37NCBI BioSystems Database
See all sources

Pathways related to Proctitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MPO, CRP, TNF

Compounds for genes affiliated with Proctitis

About this section
Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
See all sources

Compounds related to Proctitis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1pge24410.7EPX
2estrogen4410.3KLK3, LTF, RNASE3
3endotoxin4410.2RNASE3, LTF, EDNRA
4hydrocortisone44 2 59 1113.2KLK3, LTF, FGF2
5tenidap44 2811.2TNF, LTF, CRP
6cyclophosphamide44 49 1112.1CRP, CYP2E1, TF
7thiocyanate44 2411.1LTF, MPO, EPX
8polysaccharide4410.0LCN2, KLK3, RNASE3
9erythromycin44 49 2 1113.0CYP2E1, LTF, PPIG
10cytochalasin b4410.0MPO, RNASE3, EPX, LTF
11zymosan4410.0RNASE3, TNF, LTF, MPO
12methacholine44 1110.9MPO, LTF, RNASE3, CRP
13diazepam44 49 28 1112.9LTF, CYP2E1, FGF2, PPIG
14vitamin a44 11 2411.8LCN2, FGF2, LTF, CYP2E1
158-isoprostane449.8TNF, TF, MPO, CRP
16budesonide44 49 1111.8TNF, MPO, LTF, EPX, RNASE3
17azelastine44 1110.8PPIG, CYP2E1, RNASE3
18vitamin b12449.8CRP, MPO, LTF, TF
19dapsone2 44 49 1112.8EPX, PPIG, MPO, CYP2E1
20mitoxantrone44 49 1111.7KLK3, CYP2E1, ATM, MPO
21betacarotene449.7KLK3, TF, CRP, CYP2E1
22theophylline44 28 11 2412.7CRP, RNASE3, PPIG, CYP2E1, EPX
23pentoxifylline44 1110.7CYP2E1, LTF, TNF, MPO
24antipyrine44 1110.7CYP2E1, PPIG, TF
25thalidomide44 49 59 1112.7FGF2, KLK3, TNF, CYP2E1
26neopterin449.7CRP, TNF, LCN2, LTF
27n-formylmethionyl-leucylphenylalanine449.6LCN2, MPO, LTF, TNF, RNASE3
28iron44 2410.6TF, ATM, EPX, EDNRA, LCN2, LTF
29h2o2449.5FGF2, CYP2E1, EPX, MPO, EDNRA, LTF
30formaldehyde44 2410.5CYP2E1, EDNRA, MPO, EPX, RNASE3, KLK3
31prostacyclin449.5ENTPD1, FGF2, TNF, TF, EDNRA, CRP
32leukotriene b444 59 2411.5MPO, LTF, LCN2, TNF, EPX, RNASE3
33ascorbic acid44 2410.5MPO, CRP, TF, LTF, CYP2E1, FGF2
34fmlp449.4MPO, LCN2, LTF, EPX, RNASE3, TNF
35fibrinogen449.4RNASE3, LCN2, LTF, TNF, TF, CRP
36latex449.4RNASE3, LTF, EDNRA, CRP
37clozapine44 28 49 1112.4MPO, CYP2E1, PPIG, CRP
38histamine44 28 2411.4TF, RNASE3, TNF, EPX, MPO, LTF
39cyclosporin a44 28 5911.4RNASE3, TNF, LTF, FGF2, EDNRA, TF
40n acetylcysteine449.3TNF, TF, CRP, MPO, ATM, LTF
41serine449.3FGF2, EPX, LTF, MPO, KLK3, TNF
42dexamethasone44 49 28 1112.2RNASE3, KLK3, PPIG, EDNRA, LTF, CYP2E1
43paraffin449.2TF, KLK3, MPO, CDH3, FGF2, LTF
44vegf448.9RNASE3, CRP, TF, EDNRA, MPO, TNF
45lactate448.8ATM, MPO, TF, TNF, KLK3, EPX
46creatinine448.8LCN2, TF, EDNRA, CRP, LTF, MPO
47nitric oxide44 11 2410.8RNASE3, TNF, LCN2, MPO, ENTPD1, EPX
48prednisolone44 28 1110.8RNASE3, TNF, EDNRA, TF, MPO, EPX
49lipid448.7ATM, TNF, EDNRA, CYP2E1, CRP, RNASE3
50tyrosine448.5CDH3, CD6, LCN2, EDNRA, ATM, RNASE3

GO Terms for genes affiliated with Proctitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2RNASE3, FGF2, LTF, CRP, TF, APOLD1

Biological processes related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascadeGO:0703749.8FGF2, EDNRA, TNF
2negative regulation of lipid storageGO:0108889.7TNF, CRP
3response to hypoxiaGO:0016669.0ATM, CRP, EDNRA, APOLD1, TNF

Molecular functions related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.1LTF, TF

Products for genes affiliated with Proctitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Proctitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet