Proctitis malady

Disease Ontology: A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. sexually transmitted pathogens (neisseria gonorrhoeae, chlamydia trachomatis, herpes simplex virus 1 and 2, treponema pallidum) and enteric pathogens (campylobacter, shigella, salmonella) are involved in the disease. symptoms are rectal discomfort and bleeding.⁶

MalaCards: Proctitis, also known as proctitis nos (disorder), is related to ulcerative proctitis and ulcerative colitis. An important gene associated with Proctitis is PLEK2 (pleckstrin 2), and among its related pathways are Asthma and Carbamazepine Pathway, Pharmacokinetics. The drug mesalamine and the compounds cyclophosphamide and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotype hematopoietic system.

Wikipedia: Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6⁴⁴ more...

Aliases & Descriptions:

proctitis 6 8 32 43 proctitis nos (disorder) 6

proctitis (disorder) 6 proctitis nos 6

Diseases related to proctitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 380)

id	Related Disease	Score	Top Affiliating Genes
1	ulcerative proctitis	32.6	MRPL13, CRP, PLEK2
2	ulcerative colitis	25.9	LCN2, MPO, CDH3, FGF2, IL8, TNF
3	prostatitis	22.3	LCN2, ATM, MPO, CDH3, FGF2, IL8
4	blindness	22.0	LCN2, MPO, CDH3, FGF2, IL8, TNF
5	pyuria	13.6	CRP, PLEK2
6	giant papillary conjunctivitis	13.6	RNASE3, LTF
7	eosinophil peroxidase deficiency	13.5	MPO, EPX
8	food allergy	13.5	RNASE3, ABP1, EPX
9	mononeuritis multiplex	13.4	MPO, CRP
10	mononeuritis	13.4	MPO, CRP
11	bladder disease	13.4	PPIG, KLK3
12	chronic rhinitis	13.3	MPO, RNASE3, EPX
13	chronic maxillary sinusitis	13.3	MPO, RNASE3
14	pelvic inflammatory disease	13.3	LCN2, MPO, CRP
15	collagenous colitis	13.2	MPO, RNASE3, LTF, EPX
16	epidural abscess	13.2	MRPL13, TNF, CRP
17	cold agglutinin disease	13.2	TNF, CRP
18	onchocerciasis	13.1	TNF, RNASE3, EPX
19	hyper-igd syndrome	13.1	TNF, CRP
20	churg-strauss syndrome	13.1	MPO, CRP, RNASE3, LTF
21	impotence	13.1	CYP3A4, KLK3, EDNRA
22	hyperferritinemia-cataract syndrome	13.1	CRP, TF
23	prostate disease	13.0	FGF2, CRP, KLK3
24	vernal keratoconjunctivitis	13.0	FGF2, RNASE3, ABP1
25	slow-channel congenital myasthenic syndrome	13.0	IL8, CRP
26	rapidly progressive glomerulonephritis	13.0	MPO, TNF, CRP
27	anus cancer	13.0	CD6, APOLD1
28	specific granule deficiency	13.0	IL8, LTF
29	female breast cancer	12.9	ATM, TNF, KLK3
30	systolic heart failure	12.9	MPO, TNF, CRP
31	erythropoietic protoporphyria	12.9	CYP2E1, TF, EPX
32	venous insufficiency	12.9	FGF2, PPIG, CRP
33	microscopic polyangiitis	12.9	MPO, TNF, CRP
34	mixed connective tissue disease	12.9	TNF, CRP, EDNRA
35	schistosomiasis	12.9	TNF, CRP, RNASE3, EPX
36	pulmonary eosinophilia	12.9	IL8, RNASE3, EPX
37	klebsiella	12.8	LCN2, MPO, TNF
38	deep vein thrombosis	12.8	TNF, CRP, ABP1
39	fascioliasis	12.8	TNF, CYP3A4, RNASE3
40	brucellosis	12.8	MPO, TNF, CRP
41	crescentic glomerulonephritis	12.8	MPO, TNF, CRP
42	henoch-schoenlein purpura	12.8	MPO, RNASE3
43	ischemic heart disease	12.8	ENTPD1, CYP3A4, CRP, EDNRA
44	irritable bowel syndrome	12.8	MPO, TNF, LTF, EPX
45	pemphigus	12.8	CDH3, TNF, CRP, RNASE3
46	fabry disease	12.8	LCN2, MPO, TNF, CRP
47	collagen disease	12.8	FGF2, TNF, CRP
48	cadasil	12.7	LCN2, ENTPD1, PPIG, CRP, EDNRA
49	disseminated intravascular coagulation	12.7	MPO, TNF, CRP, KLK3
50	cystic fibrosis lung disease	12.7	MPO, IL8

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 mesalamine

MalaCards organs/tissues related to proctitis:

²²

MGI Mouse Phenotypes related to proctitis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.4	LCN2, ATM, FGF2, EPX

Articles related to proctitis:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	Infliximab for refractory ulcerative proctitis. (20222911)	Bouguen G.... Peyrin-Biroulet L.	2010	CRP
2	Safety and efficacy of Qingre Buyi Decoction in the t reatment of acute radiation proctitis: a prospective, randomized and controlled trial. (19688315)	Wang L.... Wang Y.	2009	ABP1
3	Faecal calprotectin and lactoferrin values during irr adiation of prostate cancer correlate with chronic radiation proctitis: results of a prospective study. (19504404)	Hille A.... Ramadori G.	2009	LTF
4	Up-regulation of endothelin type a receptor in human and rat radiation proctitis: preclinical therapeutic approach with endothelin receptor blockade. (19427554)	Jullien N.... FranAsois A.	2009	EDNRA
5	Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis. (19337853)	Sheth S.... Robson S.C.	2009	ENTPD1
6	A prospective study of faecal calprotectin and lactoferrin in the monitoring of acute radiation proctitis in prostate cancer treatment. (18938774)	Hille A.... Ramadori G.	2008	LTF
7	Expression of cytochrome P450 and MDR1 in patients with proctitis. (18484072)	ThAPrn M.... LAPAPf L.	2007	CYP3A4, CYP2E1, PPIG
8	Faecal calprotectin and lactoferrin as markers of acute radiation proctitis: a pilot study of eight stool markers. (15545170)	Larsen A.... Fagerhol M.K.	2004	TNF, TF, LTF
9	Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis. (11889070)	Carlson M.... Venge P.	2002	MPO, IL8, LCN2
10	Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis. (12353856)	Sangfelt P.... Raab Y.	2002	TNF, IL8, LCN2
11	Transient P-cadherin expression in radiation proctitis; a model of mucosal injury and repair. (12015743)	Hardy R.G.... Sanders D.S.	2002	CDH3
12	Neutrophil and eosinophil granule proteins as markers of response to local prednisolone treatment in distal ulcerative colitis and proctitis. (11316151)	Sangfelt P.... Raab Y.	2001	MPO, EPX, RNASE3
13	Increased intraluminal release of eosinophil granule proteins EPO, ECP, EPX, and cytokines in ulcerative colitis and proctitis in segmental perfusion. (10406252)	Carlson M.... Venge P.	1999	IL8, EPX, RNASE3
14	A phase III double-blind randomised study of rectal s ucralfate suspension in the prevention of acute radiation proctitis. (9424000)	O'Brien P.C.... Denham J.W.	1997	FGF2

Genes related to proctitis according to GeneCards:

(show all 24)

id	Symbol	Description	Score	GeneCards Section Context
1	PLEK2	pleckstrin 2	11.0
2	EPX	eosinophil peroxidase	11.0	Publications
3	MRPL13	mitochondrial ribosomal protein L13	11.0
4	LCN2	lipocalin 2	11.0	Publications
5	LTF	lactotransferrin	11.0	Publications
6	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
7	KLK3	kallikrein-related peptidase 3	11.0
8	ATM	ataxia telangiectasia mutated	11.0
9	CRP	C-reactive protein, pentraxin-related	11.0	Publications
10	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	11.0	Publications
11	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
12	CDH3	cadherin 3, type 1, P-cadherin (placental)	11.0	Publications
13	CD6	CD6 molecule	11.0
14	APOLD1	apolipoprotein L domain containing 1	11.0
15	PPIG	peptidylprolyl isomerase G (cyclophilin G)	11.0	Publications
16	EDNRA	endothelin receptor type A	11.0	Publications
17	NXN	nucleoredoxin	11.0	Disorders
18	MPO	myeloperoxidase	11.0	Publications
19	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
20	TF	transferrin	11.0	Publications
21	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
22	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0	Publications
23	IL8	interleukin 8	11.0	Publications
24	TNF	tumor necrosis factor	11.0	Publications

Pathways related to proctitis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Asthma20	9.5	TNF, RNASE3, EPX
2	Carbamazepine Pathway, Pharmacokinetics34	9.4	CYP3A4, CYP2E1
3	Caffeine Pathway, Pharmacokinetics34	9.4	CYP3A4, CYP2E1
4	Theophylline Pathway, Pharmacokinetics34	9.1	CYP3A4, CYP2E1

Compounds related to proctitis according to GeneDecks:

(show top 50)    (show all 229)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.6	LTF
2	n acetylcysteine32	10.3	LTF, ATM, RNASE3
3	tele-methylhistamine32	10.0	ABP1, EPX, RNASE3
4	endotoxin32	9.9	LTF, EDNRA, ABP1, CRP
5	budesonide32 42 9 9	12.8	RNASE3, LTF, EPX, CYP3A4
6	6-hydroxychlorzoxazone32	9.5	PPIG, CYP3A4, CYP2E1
7	zymosan32	9.5	LTF, RNASE3, TNF, MPO
8	h2o232	9.4	LTF, EDNRA, MPO, ABP1, RNASE3, EPX
9	felbamate32 9 9	11.4	CYP2E1, CYP3A4, PPIG
10	histamine32 18	10.3	ABP1, MPO, RNASE3, LTF, EPX, TF
11	vitamin a32 9 18 9	12.3	CRP, LTF, TF, CYP2E1, LCN2
12	azelastine32 9 9	11.3	CYP2E1, PPIG, CYP3A4, RNASE3
13	pge232	9.2	FGF2, TF, LTF, EDNRA, EPX
14	coumarin32 18	10.2	CYP3A4, PPIG, CYP2E1, KLK3
15	furafylline32	9.1	CYP3A4, PPIG, CYP2E1
16	omeprazole32 42 34 9 18 9	14.1	CYP2E1, PPIG, CRP, CYP3A4
17	ascorbic acid32 18	10.1	TF, CYP2E1, LTF
18	diethylstilbestrol32 9 9	11.1	CYP3A4, CYP2E1, LTF, KLK3
19	methacholine32 9 9	11.0	RNASE3, LTF, IL8, MPO, CRP
20	mitoxantrone32 9 9	11.0	KLK3, CYP2E1, CYP3A4, MPO, ATM
21	dapsone32 34 9 9	12.0	PPIG, CYP2E1, EPX, CYP3A4, MPO
22	salmeterol32 42 9 9	12.0	EPX, IL8, RNASE3, CYP3A4
23	antipyrine32 9 9	11.0	CYP3A4, CYP2E1, PPIG, TF
24	theophylline32 9 18 9	12.0	EPX, CYP2E1, CYP3A4, RNASE3, PPIG, CRP
25	salbutamol32 34 9 18 9	12.8	EPX, IL8, CYP3A4, RNASE3
26	neopterin32	8.8	CRP, LCN2, IL8, LTF, TNF
27	clozapine32 34 9 9	11.8	MPO, CYP3A4, CYP2E1, PPIG, CRP
28	iron32 18	9.7	LTF, TF, EDNRA, EPX, CRP, MPO
29	sulfasalazine32 9 9	10.7	MPO, TNF, CRP, IL8
30	n-formylmethionyl-leucylphenylalanine32	8.6	TNF, LCN2, IL8, RNASE3, MPO, LTF
31	formaldehyde32 18	9.6	MPO, CYP3A4, CYP2E1, RNASE3, EPX, EDNRA
32	pentoxifylline32 9 9	10.5	IL8, TNF, MPO, LTF, CYP2E1
33	leukotriene b432 42 18	10.5	MPO, EPX, LCN2, IL8, LTF, TNF
34	8-isoprostane32	8.5	MPO, IL8, TNF, CRP, TF
35	prostacyclin32	8.4	TF, LTF, CRP, TNF, ENTPD1, FGF2
36	fluticasone propionate32 42 9 9	11.3	CYP3A4, TNF, IL8, RNASE3, MPO
37	paraffin32	8.3	EDNRA, KLK3, LTF, TF, ATM, MPO
38	fmlp32	8.2	ABP1, LTF, RNASE3, EPX, LCN2, MPO
39	erythromycin32 9 9	10.2	PPIG, MPO, IL8, CYP3A4, CYP2E1, LTF
40	creatinine32	8.2	EPX, LTF, MPO, CRP, TF, ABP1
41	estrogen32	8.0	TF, EDNRA, CDH3, LTF, LCN2, KLK3
42	superoxide32 18	8.9	LCN2, IL8, LTF, TNF, EPX, ABP1
43	nitric oxide32 9 18 9	10.6	MPO, CDH3, EPX, EDNRA, RNASE3, TNF
44	hydrocortisone32 9 9	9.6	LTF, IL8, TNF, TF, FGF2, KLK3
45	prednisolone32 9 9	9.3	EPX, CYP3A4, LCN2, TF, RNASE3, EDNRA
46	lactate32	7.1	KLK3, CYP2E1, IL8, EPX, TF, ABP1
47	vegf32	7.0	IL8, MPO, FGF2, TNF, CRP, RNASE3
48	cyclosporin a32 42	8.0	CYP3A4, PPIG, TF, RNASE3, FGF2, LTF
49	oxygen32 18	7.9	TNF, EPX, MPO, ABP1, EDNRA, CYP2E1
50	dexamethasone32 42 34 9 9	10.6	EPX, EDNRA, KLK3, FGF2, IL8, TNF

Cellular components related to proctitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.4	LCN2, FGF2, IL8, APOLD1, CRP, RNASE3

Biological processes related to proctitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of lipid storage	GO:010888	9.6	TNF, CRP
2	heterocycle metabolic process	GO:046483	9.4	CYP3A4, CYP2E1
3	monoterpenoid metabolic process	GO:016098	9.1	CYP3A4, CYP2E1
4	response to hypoxia	GO:001666	9.0	ATM, APOLD1, TNF, CRP, EDNRA
5	oxidation-reduction process	GO:055114	8.8	ABP1, CYP2E1, CYP3A4, MPO

Molecular functions related to proctitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavopr	GO:016712	9.4	CYP3A4, CYP2E1
2	heparin binding	GO:008201	9.1	MPO, FGF2, LTF, ABP1
3	heme binding	GO:020037	8.6	EPX, CYP2E1, CYP3A4, MPO