Aliases & Classifications for Proctitis

MalaCards integrated aliases for Proctitis:

Name: Proctitis 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3127
ICD10 33 K62.89
MeSH 42 D011349
NCIt 47 C38011
UMLS 69 C0033246

Summaries for Proctitis

Disease Ontology : 12 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding.

MalaCards based summary : Proctitis is related to radiation proctitis and ulcerative proctitis, and has symptoms including rectal tenesmus An important gene associated with Proctitis is EPX (Eosinophil Peroxidase), and among its related pathways/superpathways are Overview of nanoparticle effects and LDL Oxidation in Atherogenesis. The drugs Tacrolimus and Sucralfate have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and neutrophil, and related phenotype is immune system.

Wikipedia : 72 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last... more...

Related Diseases for Proctitis

Diseases related to Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
id Related Disease Score Top Affiliating Genes
1 radiation proctitis 12.3
2 ulcerative proctitis 12.3
3 primary syringomyelia 10.7 EPX RNASE3
4 cecum adenoma 10.7 EPX RNASE3
5 winchester syndrome 10.7 EPX RNASE3
6 lymphocytic gastritis 10.7 EPX RNASE3
7 eosinophilic enteropathy 10.7 EPX MPO
8 acute gonococcal prostatitis 10.7 EPX RNASE3
9 bulbomembranous urethral cancer 10.6 EPX MPO
10 autoimmune oophoritis 10.6 MPO TNF
11 autoimmune neuropathy 10.6 EPX RNASE3
12 vulvar disease 10.6 MPO RNASE3
13 migraine with brainstem aura 10.6 MPO TNF
14 anencephaly and spina bifida x-linked 10.6 MPO TNF
15 uveitis 10.6 MPO TNF
16 epstein-barr virus hepatitis 10.6 CRP TNF
17 dislocation of ear ossicle 10.6 MPO RNASE3
18 euthyroid sick syndrome 10.6 CRP TNF
19 cannabis dependence 10.6 CRP MPO
20 mechanical lagophthalmos 10.6 CRP TNF
21 nodular ganglioneuroblastoma 10.6 CRP MPO
22 sphenoid sinusitis 10.5 MPO RNASE3
23 myotonic cataract 10.5 CRP MPO
24 leukocyte disease 10.5 EPX RNASE3
25 cicatricial lagophthalmos 10.5 CRP TNF
26 petrous apex meningioma 10.5 CRP TNF
27 polyarteritis nodosa 10.5 CRP TNF
28 focal embolic glomerulonephritis 10.5 CRP MPO
29 partial circumpapillary choroid dystrophy 10.5 CRP MPO
30 islet cell tumor 10.5 CRP TNF
31 placental abruption 10.5 CRP TNF
32 inhalation anthrax 10.5 CRP MPO
33 functional gastric disease 10.5 CRP TNF
34 whistling face syndrome, recessive form 10.5 CRP RNASE3
35 megaloblastic anemia 10.5 CRP TNF
36 benign neonatal seizures 10.5 CRP TNF
37 gastroduodenal crohn's disease 10.5 MPO TNF
38 hypochondriasis 10.4 KLK3 TNF
39 inflamed seborrheic keratosis 10.4 EPX RNASE3
40 familial mediterranean fever, ad 10.4 CRP TNF
41 phlegmonous dacryocystitis 10.4 KDR MPO
42 hepatocellular adenoma 10.4 CRP MPO
43 hypolipoproteinemia 10.4 CRP MPO
44 myeloid sarcoma 10.4 CRP TNF
45 partial central choroid dystrophy 10.4 CRP MPO
46 patau syndrome 10.4 CRP TNF
47 spontaneous ocular nystagmus 10.4 EPX RNASE3 TNF
48 early congenital syphilis 10.4 CRP TNF
49 clostridium difficile colitis 10.4 EPX MPO RNASE3
50 colitis 10.4

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to Proctitis

Symptoms & Phenotypes for Proctitis

UMLS symptoms related to Proctitis:


rectal tenesmus

MGI Mouse Phenotypes related to Proctitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 TNF CRP ENTPD1 EPX KDR LTF

Drugs & Therapeutics for Proctitis

Drugs for Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
2
Sucralfate Approved Phase 4 54182-58-0
3 Calcineurin Inhibitors Phase 4,Phase 2
4 Immunosuppressive Agents Phase 4,Phase 2
5 Antacids Phase 4
6 Anti-Ulcer Agents Phase 4
7 Gastrointestinal Agents Phase 4,Phase 2
8
Budesonide Approved Phase 3,Phase 2 51333-22-3 63006 5281004
9
Inulin Approved, Nutraceutical Phase 3 9005-80-5 24763
10 Anti-Asthmatic Agents Phase 3,Phase 2
11 Anti-Inflammatory Agents Phase 3,Phase 2
12 Autonomic Agents Phase 3,Phase 2
13 Bronchodilator Agents Phase 3,Phase 2
14 glucocorticoids Phase 3,Phase 2
15 Hormone Antagonists Phase 3,Phase 2
16 Hormones Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Respiratory System Agents Phase 3,Phase 2
20 Analgesics Phase 3,Phase 2
21 Analgesics, Non-Narcotic Phase 3,Phase 2
22 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
23 Antirheumatic Agents Phase 3,Phase 2
24 Mesalamine Phase 3,Phase 2 89-57-6
25 Cola Nutraceutical Phase 3,Phase 2
26 Acidophilus Nutraceutical Phase 2, Phase 3
27
Bisacodyl Approved Phase 2 603-50-9
28
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
29
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
30
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
31
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
32
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741 24759
33 Orange Approved, Nutraceutical Phase 2
34
Curcumin Investigational Phase 2 458-37-7 969516
35
Epinephrine Approved, Vet_approved 51-43-4 5816
36 Racepinephrine Approved
37 Epinephryl borate

Interventional clinical trials:

(show all 37)

id Name Status NCT ID Phase Drugs
1 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
2 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
3 CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Withdrawn NCT00756197 Phase 4
4 Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. Unknown status NCT01414517 Phase 3
5 The Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Completed NCT01349673 Phase 3 Budesonide Foam
6 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms Completed NCT01901042 Phase 2, Phase 3
7 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3 Budesonide;Placebo
8 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3 Budesonide;Placebo
9 Efficacy and Safety Study of MAX-002 Suppository Versus Placebo in Mild to Moderate Ulcerative Proctitis Terminated NCT01016262 Phase 3 MAX-002;Placebo;Canasa®
10 Clinical Trial With Mesalamine 1g Suppositories Terminated NCT01172444 Phase 3 Mesalamine;Canasa;Placebo
11 Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries Terminated NCT00134628 Phase 3
12 Safety, Tolerability, Biomarker and Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis Unknown status NCT01149707 Phase 2 PUR 0110 Rectal Enema 250 mg;PUR 0110 Rectal Enema 500 mg;PUR 0110 Rectal Enema 1000 mg;Placebo Enema
13 Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis Completed NCT01966783 Phase 2 Budesonide 2 mg suppository;Budesonide 4 mg suppository;Mesalazine 1 g suppository;Budesonide 2 mg suppository/Mesalazine 1 g suppository
14 Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis Completed NCT01837615 Phase 2
15 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
16 Ion Prostate Irradiation Completed NCT01641185 Phase 2
17 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2 cisplatin
18 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
19 Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease Recruiting NCT03077412 Phase 2 Filgotinib;Placebo to match filgotinib
20 Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT) Active, not recruiting NCT02724618 Phase 2 Curcumin;Placebo
21 Brachytherapy for Recurrent Prostate Cancer Active, not recruiting NCT01956058 Phase 2
22 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
23 Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2 budesonide;Placebo foam
24 Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome Withdrawn NCT00514982 Phase 2 Mesalamine;Infliximab;Corticosteroids;6-Mercaptopurine;Tacrolimus;Adalimumab
25 Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis Unknown status NCT02233933
26 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492
27 Evaluation of PillCam IBD Capsule Endoscopy System in Visualization of Lesions in the Colon Indicative of Ulcerative Colitis Disease Completed NCT02025777
28 Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment Completed NCT01684514
29 Patients Overexposed for a Prostate Adenocarcinoma Completed NCT00773656
30 Feasibility of Online Adaptive Radiotherapy for Muscle Invasive Bladder Cancer Completed NCT01142102
31 Quality of Life Study Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent Recruiting NCT02836379
32 Effect of a Low Residue Diet in Comparison to the Dietetic Recommendations From the INCan in Cervical Cancer Patients Recruiting NCT03100409
33 Invasive Group A Streptococcus (GAS) Infection in Children: Bacterial Virulence Factors and Detection of Host Immunological and/or Genetic Factors of Predisposition to Infections Recruiting NCT02010294
34 Faecal Incontinence iNtervention Study Recruiting NCT02355834
35 Phenomics in Autoimmune and Inflammatory Diseases Recruiting NCT02466217
36 QUality of Life in pAtients With Mild to modeRate Active procTitis Treated by mesalaZine (Pentasa®) Active, not recruiting NCT02368743 mesalazine
37 Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis Not yet recruiting NCT03259659

Search NIH Clinical Center for Proctitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: proctitis

Genetic Tests for Proctitis

Anatomical Context for Proctitis

MalaCards organs/tissues related to Proctitis:

39
Prostate, Colon, Neutrophil, Endothelial, Cervix, Bone, Skin

Publications for Proctitis

Articles related to Proctitis:

(show top 50) (show all 606)
id Title Authors Year
1
Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. ( 28618234 )
2017
2
Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis. ( 28286194 )
2017
3
Endoscopic diode laser therapy for chronic radiation proctitis. ( 28895000 )
2017
4
Clinical and microbiological aspects of the use of Lactobacillus rhamnosus PL1 strains in proctological patients with symptoms of chronic proctitis. ( 28703111 )
2017
5
Chlamydia trachomatis proctitis masquerading as carcinoma rectum: First case report from India. ( 28631649 )
2017
6
Therapeutic requirements in active ulcerative proctitis: A single-centre study. ( 28666605 )
2017
7
Lymphoid follicular proctitis resembling rectal carcinoid tumor, confirmed by endoscopic resection. ( 28415161 )
2017
8
Efficacy and safety of argon plasma coagulation in the management of extensive chronic radiation proctitis after pelvic radiotherapy for cervical carcinoma. ( 28707144 )
2017
9
Two Cases of Neisseria meningitidis Proctitis in HIV-Positive Men Who Have Sex with Men. ( 28221124 )
2017
10
Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. ( 28232224 )
2017
11
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
12
Proctitis And Anusitis ( 28613642 )
2017
13
Herpes Simplex Proctitis Mimicking Inflammatory Bowel Disease in a Teenaged Male. ( 28473937 )
2017
14
Co-infection by lymphogranuloma venereum and Haemophilus parainfluenzae during an episode of proctitis. ( 28196678 )
2017
15
Editorial: does disease extension lead to disease progression in proctitis? ( 28621077 )
2017
16
Correlation between Disease Activity and Endorectal Ultrasound Findings of Chronic Radiation Proctitis. ( 28755790 )
2017
17
Lymphogranuloma Venereum Proctitis. ( 28365488 )
2017
18
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. ( 28694461 )
2017
19
Ischemic Proctitis Presenting as Rectal Pain and Bloody Diarrhea with No Apparent Cause. ( 28761891 )
2017
20
Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis. ( 28922252 )
2017
21
Chronic haemorrhagic radiation proctitis: A review. ( 27462390 )
2016
22
Baseline Oral 5-ASA Use and Efficacy and Safety of Budesonide Foam in Patients with Ulcerative Proctitis and Ulcerative Proctosigmoiditis: Analysis of 2 Phase 3 Studies. ( 27416045 )
2016
23
Azathioprine for refractory ulcerative proctitis: A retrospective multicenter study. ( 28089625 )
2016
24
The contribution of Mycoplasma genitalium to the aetiology of sexually acquired infectious proctitis in men who have sex with men. ( 26686807 )
2016
25
Did L Strains Responsible for Lymphogranuloma Venereum Proctitis Spread Among People With Genital Chlamydia trachomatis Infection in France in 2013? ( 27200521 )
2016
26
Lymphogranuloma venereum proctitis. ( 27695183 )
2016
27
Impact of treatment time-related factors on prognoses and radiation proctitis after definitive chemoradiotherapy for cervical cancer. ( 27416796 )
2016
28
Flagellin preconditioning enhances the efficacy of mesenchymal stem cells in an irradiation-induced proctitis model. ( 26992430 )
2016
29
Exploring the Management of Radiation Proctitis in Current Clinical Practice. ( 27504391 )
2016
30
Proctitis 1 Week after Stereotactic Body Radiation Therapy for Prostate Cancer: Implications for Clinical Trial Design. ( 27489794 )
2016
31
Syphilitic proctitis. ( 27365889 )
2016
32
Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. ( 27446860 )
2016
33
Complication and remission rates after endoscopic argon plasma coagulation in the treatment of haemorrhagic radiation proctitis. ( 27527929 )
2016
34
Long-term results on the efficacy of argon plasma coagulation for patients with chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy for prostate cancer. ( 27663931 )
2016
35
Clinical pattern and progression of ulcerative proctitis in the Japanese population: a retrospective study of incidence and risk factors influencing progression. ( 26663677 )
2016
36
Purulent Proctitis Caused by Prevotella bivia in a Homosexual Male. ( 28008411 )
2016
37
Severe Proctitis Caused by Chlamydia trachomatis Serovars D. ( 27803429 )
2016
38
Ulcerative proctitis is a frequent location of paediatric-onset UC and not a minor disease: a population-based study. ( 27489240 )
2016
39
Efficacy and safety of Yunxiangjing derived from Chinese herbal medicine administered as an enema in the management of acute radiation-induced proctitis in patients with pelvic malignancy. ( 26946618 )
2016
40
Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development. ( 26925655 )
2016
41
Colostomy is a simple and effective procedure for severe chronic radiation proctitis. ( 27350738 )
2016
42
MRI characteristics of proctitis in Crohn's disease on perianal MRI. ( 27315072 )
2016
43
Sphincter-sparing intersphincteric rectal resection as an alternative to proctectomy in long-standing fistulizing and stenotic Crohn's proctitis? ( 25847822 )
2015
44
A case of appendectomy as main therapeutic intervention for complex co-morbid ulcerative proctitis. ( 25690705 )
2015
45
Dual-modal ablation treatment for refractory radiation proctitis. ( 26272198 )
2015
46
Severe distal ischemic proctitis with venous congestion following anterior resection for sigmoid colon cancer: the importance of Sudeck's point. ( 26346928 )
2015
47
Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients. ( 25890844 )
2015
48
Pathogenesis, diagnosis, and management of ulcerative proctitis, chronic radiation proctopathy, and diversion proctitis. ( 25687266 )
2015
49
The Painful Diversity of Proctitis in the Modern Era. ( 26736144 )
2015
50
Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis. ( 26386854 )
2015

Variations for Proctitis

Expression for Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for Proctitis

Pathways related to Proctitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.43 CRP TNF
2 10.16 MPO TNF
3 9.8 CYP3A5 MPO

GO Terms for Proctitis

Cellular components related to Proctitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 CRP ENTPD1 EPX KLK3 LTF MPO
2 extracellular space GO:0005615 9.5 CRP EPX KLK3 LTF MPO RNASE3
3 extracellular region GO:0005576 9.23 CRP EPX KDR KLK3 LTF MPO

Biological processes related to Proctitis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.71 EPX LTF MPO RNASE3
2 defense response GO:0006952 9.5 EPX MPO TNF
3 negative regulation of viral genome replication GO:0045071 9.49 LTF TNF
4 antibacterial humoral response GO:0019731 9.46 LTF RNASE3
5 innate immune response in mucosa GO:0002227 9.43 LTF RNASE3
6 hydrogen peroxide catabolic process GO:0042744 9.37 EPX MPO
7 defense response to Gram-positive bacterium GO:0050830 9.33 CRP RNASE3 TNF
8 negative regulation of growth of symbiont in host GO:0044130 9.26 MPO TNF
9 protein kinase B signaling GO:0043491 9.18 TNF
10 negative regulation of lipid storage GO:0010888 8.96 CRP TNF
11 defense response to bacterium GO:0042742 8.92 LTF MPO RNASE3 TNF

Molecular functions related to Proctitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 EPX MPO
2 lipopolysaccharide binding GO:0001530 8.85 LTF
3 heme binding GO:0020037 8.8 CYP3A5 EPX MPO

Sources for Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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