MCID: PRC003
MIFTS: 49

Proctitis malady

Summaries for Proctitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. sexually transmitted pathogens (neisseria gonorrhoeae, chlamydia trachomatis, herpes simplex virus 1 and 2, treponema pallidum) and enteric pathogens (campylobacter, shigella, salmonella) are involved in the disease. symptoms are rectal discomfort and bleeding.

MalaCards: Proctitis, also known as proctitis nos, is related to ulcerative colitis and systemic lupus erythematosus. An important gene associated with Proctitis is LTF (lactotransferrin), and among its related pathways is Selenium Pathway. The drug mesalamine and the compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and small intestine, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:64 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6 more...

Aliases & Classifications for Proctitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

proctitis 8 10 45 61
proctitis nos 8


External Ids:

Disease Ontology8 DOID:3127
MeSH35 D011349
NCIt40 C38011

Related Diseases for Proctitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Proctitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.0TNF, CRP, LTF
2systemic lupus erythematosus30.1CRP
3crohn's disease30.1LTF, CRP, TNF
4arthritis30.0TNF, CRP, MPO, LTF, FGF2
5collagenous colitis29.8RNASE3
6hepatitis b29.8LTF, PPIG
7cystic fibrosis29.8MPO, LTF, RNASE3, ENTPD1
8hepatitis c29.8TNF, TF, LTF, CYP2E1
9colorectal cancer29.8APOLD1, PPIG, EDNRA, ATM, LTF, CDH3
10radiation proctitis11.1
11ulcerative proctitis10.9
12lymphogranuloma venereum10.6
13trachoma10.5
14radiation cystitis10.3
15rectal prolapse10.1
16radiation induced cancer10.1
17cytomegalovirus infection10.1
18reactive arthritis10.1
19pouchitis10.0LTF
20irritable bowel syndrome10.0LTF
21sinusitis10.0RNASE3
22gastritis10.0LTF
23thromboembolism10.0ENTPD1
24cervical cancer10.0LTF
25bronchopulmonary dysplasia10.0RNASE3
26chronic rhinitis10.0RNASE3
27endocarditis10.0EPX
28stroke, ischemic10.0ENTPD1
29gingivitis10.0LTF
30gastric ulcer10.0FGF2
31acute myocardial infarction10.0CRP
32eosinophil peroxidase deficiency10.0EPX
33coronary heart disease10.0CRP
34protein-energy malnutrition10.0TF
35conjunctivitis10.0RNASE3
36epidural abscess10.0CRP
37bronchiolitis10.0RNASE3
38pemphigus10.0CDH3
39sickle cell disease10.0TF
40aortic aneurysm10.0CRP
41schistosomiasis10.0RNASE3
42thalassemia10.0TF
43pyelonephritis10.0CRP
44myelofibrosis10.0FGF2
45nephrotic syndrome10.0TF
46multiple sclerosis10.0TNF
47collagen disease10.0CRP
48pheochromocytoma10.0EDNRA
49hemochromatosis10.0TF
50acute pyelonephritis10.0CRP

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to proctitis

Clinical Features for Proctitis

Drugs & Therapeutics for Proctitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Proctitis

Drug clinical trials:

Search ClinicalTrials for Proctitis

Search NIH Clinical Center for Proctitis

Search CenterWatch for Proctitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Proctitis

Anatomical Context for Proctitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Proctitis:

33
Bone marrow, Spleen, Small intestine, Colon, Skin, Prostate, Cervix, Monocytes, T cells, B cells, Endothelial

Animal Models for Proctitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Proctitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.8ENTPD1, LTF, CRP, EDNRA, TF, LCN2
2MP:00053878.4EPX, LTF, ATM, MPO, CRP, EDNRA
3MP:00053978.1LTF, ATM, EDNRA, EPX, FGF2, ENTPD1

Publications for Proctitis

Sources:
51PubMed
See all sources

Articles related to Proctitis:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
Can we decrease the acute proctitis in prostate cancer patients using hyaluronic acid during radiation therapy: a prospective historically controlled clinical study. (23690202)
2013
2
A cure for post-radiation proctitis? (23736909)
2013
3
Psoriatic colitis mimicking ulcerative proctitis in an elderly patient. (22884084)
2012
4
Large-volume argon plasma coagulation in the management of chronic radiation proctitis. (21353865)
2011
5
Mast cells are an essential component of human radiation proctitis and contribute to experimental colorectal damage in mice. (21281796)
2011
6
Treatment of chronic radiation proctitis with cryoablation. (21295650)
2011
7
Endoscopic ultrasonographic features of subacute radiation proctitis. (20876905)
2010
8
Syphilitic proctitis mimicking rectal cancer: A case report. (21607150)
2010
9
Argon plasma coagulation has a long-lasting therapeutic effect in patients with chronic radiation proctitis. (19440956)
2009
10
Argon photocoagulation in the treatment of gastric antral vascular ectasia and radiation proctitis. (20011731)
2009
11
Diagnosing chlamydia and managing proctitis in men who have sex with men: current UK practice. (18077609)
2008
12
Are serological chlamydia-specific markers useful to detect asymptomatic cases of lymphogranuloma venereum proctitis? (18212189)
2008
13
Pentoxifylline to treat radiation proctitis: a small and inconclusive randomised trial. (18339525)
2008
14
Education and imaging. Gastrointestinal: radiation proctitis. (17444871)
2007
15
The 2007 European Guideline (International Union against Sexually Transmitted Infections/World Health Organization) on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens. (17686211)
2007
16
Utility of endoscopic argon plasma coagulation in the treatment of radiation proctitis. (17687188)
2007
17
Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis induces acute deterioration of mucosal blood flow. (16416079)
2006
18
Ischemic proctitis: case series and literature review. (17216829)
2006
19
Chronic constipation and food intolerance: a model of proctitis causing constipation. (15841712)
2005
20
Efficacy of rebamipide enemas in active distal ulcerative colitis and proctitis: a prospective study report. (16416182)
2005
21
Review article: problematic proctitis and distal colitis. (15352902)
2004
22
Oral mesalazine (5-ASA) treatment may protect against proximal extension of mucosal inflammation in ulcerative proctitis. (15626890)
2004
23
Chronic ischemic proctitis: case report and review. (15278070)
2004
24
Diagnosis and treatment of ulcerative proctitis. (15365396)
2004
25
Severe chemical proctitis following application of caustic native suppository. (11931191)
2002
26
Hyperbaric oxygen for the treatment of radiation cystitis and proctitis. (12084193)
2002
27
Acute radiation proctitis. (11214150)
2001
28
Ulcerative proctitis, rectal prolapse, and intestinal pseudo-obstruction in transgenic mice overexpressing hepatocyte growth factor/scatter factor. (11310823)
2001
29
Cytomegalovirus proctitis in a diabetic. (9933671)
1999
30
Neisseria meningitidis proctitis in a child after sexual abuse. (8036056)
1994
31
Glutaraldehyde-induced proctitis after endorectal ultrasound examination: a higher risk of incidence than expected? (8293929)
1993
32
Aminophylline suppository-induced acute proctitis. (1615945)
1992
33
Acute ischemic proctitis. Report of six cases. (1582361)
1992
34
Thalidomide in painful AIDS-associated proctitis. (1527434)
1992
35
Radiation-induced proctitis cystica profunda in the rat. (2364837)
1990
36
Empirical therapy for the management of acute proctitis in homosexual men. (3379743)
1988
37
Allergic proctitis. (3211813)
1988
38
Double-blind comparison of 5-aminosalicylic acid and acetyl-5-aminosalicylic acid suppositories in patients with idiopathic proctitis. (2979230)
1988
39
A controlled study of faecal distribution in ulcerative colitis and proctitis. (3433018)
1987
40
Cytotoxic and immunoregulatory function of intestinal lymphocytes in Chlamydia trachomatis proctitis of nonhuman primates. (2952593)
1987
41
Chlamydial proctitis--unusual presentation as a symptomatic vaginal mass. (6691011)
1984
42
Proctitis in homosexual men. A diagnostic problem. (6347333)
1983
43
Gonococcal proctitis: an overlooked cause of rectal inflammation. (6952048)
1982
44
Evaluation of acute proctitis. (7452845)
1981
45
Acute gangrenous proctitis. (7471462)
1980
46
The management of radiation proctitis. (6930237)
1980
47
Herpetic proctitis and sacral radiculomyelopathy in homosexual men. (227523)
1979
48
Methylene blue dye spraying method in patients with ulcerative proctitis: a comparative study with morphological findings and functional capacity of the rectal epithelium. (90610)
1979
49
Gonococcal proctitis. (682305)
1978
50
Management of advanced radiation proctitis. (13809176)
1959

Genetic Variations for Proctitis

Expression for genes affiliated with Proctitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for genes affiliated with Proctitis

Sources:
38NCBI BioSystems Database
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Pathways related to Proctitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MPO, CRP, TNF

Compounds for genes affiliated with Proctitis

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Proctitis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1pge24510.7EPX
2estrogen4510.3KLK3, LTF, RNASE3
3endotoxin4510.2RNASE3, LTF, EDNRA
4hydrocortisone45 2 60 1113.2KLK3, LTF, FGF2
5tenidap45 2911.2TNF, LTF, CRP
6cyclophosphamide45 50 1112.1CRP, CYP2E1, TF
7thiocyanate45 2411.1LTF, MPO, EPX
8polysaccharide4510.0LCN2, KLK3, RNASE3
9erythromycin45 50 2 1113.0CYP2E1, LTF, PPIG
10cytochalasin b4510.0MPO, RNASE3, EPX, LTF
11zymosan4510.0RNASE3, TNF, LTF, MPO
12methacholine45 1110.9MPO, LTF, RNASE3, CRP
13diazepam45 50 29 1112.9LTF, CYP2E1, FGF2, PPIG
14vitamin a45 11 2411.8LCN2, FGF2, LTF, CYP2E1
158-isoprostane459.8TNF, TF, MPO, CRP
16budesonide45 50 1111.8TNF, MPO, LTF, EPX, RNASE3
17azelastine45 1110.8PPIG, CYP2E1, RNASE3
18vitamin b12459.8CRP, MPO, LTF, TF
19dapsone2 45 50 1112.8EPX, PPIG, MPO, CYP2E1
20mitoxantrone45 50 1111.7KLK3, CYP2E1, ATM, MPO
21betacarotene459.7KLK3, TF, CRP, CYP2E1
22theophylline45 29 11 2412.7CRP, RNASE3, PPIG, CYP2E1, EPX
23pentoxifylline45 1110.7CYP2E1, LTF, TNF, MPO
24antipyrine45 1110.7CYP2E1, PPIG, TF
25thalidomide45 50 60 1112.7FGF2, KLK3, TNF, CYP2E1
26neopterin459.7CRP, TNF, LCN2, LTF
27n-formylmethionyl-leucylphenylalanine459.6LCN2, MPO, LTF, TNF, RNASE3
28iron45 2410.6TF, ATM, EPX, EDNRA, LCN2, LTF
29h2o2459.5FGF2, CYP2E1, EPX, MPO, EDNRA, LTF
30formaldehyde45 2410.5CYP2E1, EDNRA, MPO, EPX, RNASE3, KLK3
31prostacyclin459.5ENTPD1, FGF2, TNF, TF, EDNRA, CRP
32leukotriene b445 60 2411.5MPO, LTF, LCN2, TNF, EPX, RNASE3
33ascorbic acid45 2410.5MPO, CRP, TF, LTF, CYP2E1, FGF2
34fmlp459.4MPO, LCN2, LTF, EPX, RNASE3, TNF
35fibrinogen459.4RNASE3, LCN2, LTF, TNF, TF, CRP
36latex459.4RNASE3, LTF, EDNRA, CRP
37clozapine45 29 50 1112.4MPO, CYP2E1, PPIG, CRP
38histamine45 29 2411.4TF, RNASE3, TNF, EPX, MPO, LTF
39cyclosporin a45 29 6011.4RNASE3, TNF, LTF, FGF2, EDNRA, TF
40n acetylcysteine459.3TNF, TF, CRP, MPO, ATM, LTF
41serine459.3FGF2, EPX, LTF, MPO, KLK3, TNF
42dexamethasone45 50 29 1112.2RNASE3, KLK3, PPIG, EDNRA, LTF, CYP2E1
43paraffin459.2TF, KLK3, MPO, CDH3, FGF2, LTF
44vegf458.9RNASE3, CRP, TF, EDNRA, MPO, TNF
45lactate458.8ATM, MPO, TF, TNF, KLK3, EPX
46creatinine458.8LCN2, TF, EDNRA, CRP, LTF, MPO
47nitric oxide45 11 2410.8RNASE3, TNF, LCN2, MPO, ENTPD1, EPX
48prednisolone45 29 1110.8RNASE3, TNF, EDNRA, TF, MPO, EPX
49lipid458.7ATM, TNF, EDNRA, CYP2E1, CRP, RNASE3
50tyrosine458.5CDH3, CD6, LCN2, EDNRA, ATM, RNASE3

GO Terms for genes affiliated with Proctitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2RNASE3, FGF2, LTF, CRP, TF, APOLD1

Biological processes related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascadeGO:0703749.8FGF2, EDNRA, TNF
2negative regulation of lipid storageGO:0108889.7TNF, CRP
3response to hypoxiaGO:0016669.0ATM, CRP, EDNRA, APOLD1, TNF

Molecular functions related to Proctitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.1LTF, TF

Products for genes affiliated with Proctitis

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Sources for Proctitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet