MCID: PRG037
MIFTS: 8

Progeroid Laminopathies malady

Categories: Genetic diseases

Aliases & Classifications for Progeroid Laminopathies

Aliases & Descriptions for Progeroid Laminopathies:

Name: Progeroid Laminopathies 24

Classifications:



Summaries for Progeroid Laminopathies

MalaCards based summary : Progeroid Laminopathies An important gene associated with Progeroid Laminopathies is LMNA (Lamin A/C). The drugs Pravastatin and Zoledronic acid have been mentioned in the context of this disorder.

Related Diseases for Progeroid Laminopathies

Symptoms & Phenotypes for Progeroid Laminopathies

Drugs & Therapeutics for Progeroid Laminopathies

Drugs for Progeroid Laminopathies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pravastatin Approved Phase 2 81093-37-0 54687
2
Zoledronic acid Approved Phase 2 118072-93-8 68740
3
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
4
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
5
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
6 Diphosphonates Phase 2
7 Pharmaceutical Solutions Phase 2
8 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
9 Hypolipidemic Agents Phase 2
10 Anticholesteremic Agents Phase 2
11 Lipid Regulating Agents Phase 2
12 Antimetabolites Phase 2
13 Bone Density Conservation Agents Phase 2
14 Anti-Bacterial Agents Phase 1, Phase 2
15 Anti-Infective Agents Phase 1, Phase 2
16 Immunosuppressive Agents Phase 1, Phase 2
17 Antifungal Agents Phase 1, Phase 2
18 Antibiotics, Antitubercular Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria Completed NCT00425607 Phase 2
2 A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria Completed NCT00879034 Phase 2
3 Phase I/II Trial of Everolimus in Combination With Lonafarnib in Progeria Recruiting NCT02579044 Phase 1, Phase 2
4 Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria Enrolling by invitation NCT00916747 Phase 2

Search NIH Clinical Center for Progeroid Laminopathies

Genetic Tests for Progeroid Laminopathies

Genetic tests related to Progeroid Laminopathies:

id Genetic test Affiliating Genes
1 Progeroid Laminopathies 24 LMNA

Anatomical Context for Progeroid Laminopathies

Publications for Progeroid Laminopathies

Articles related to Progeroid Laminopathies:

id Title Authors Year
1
Progeroid laminopathy with restrictive dermopathy-like features caused by an isodisomic LMNA mutation p.R435C. ( 23804595 )
2013

Variations for Progeroid Laminopathies

Expression for Progeroid Laminopathies

Search GEO for disease gene expression data for Progeroid Laminopathies.

Pathways for Progeroid Laminopathies

GO Terms for Progeroid Laminopathies

Sources for Progeroid Laminopathies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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