MCID: PRG003
MIFTS: 36

Progesterone-Receptor Negative Breast Cancer malady

Cancer category

Summaries for Progesterone-Receptor Negative Breast Cancer

Sources:
33MalaCards
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MalaCards: Progesterone-Receptor Negative Breast Cancer is related to progesterone resistance and estrogen-receptor negative breast cancer. An important gene associated with Progesterone-Receptor Negative Breast Cancer is TWIST1 (twist basic helix-loop-helix transcription factor 1), and among its related pathways are Glioma and G-protein signaling K-RAS regulation pathway. The compounds resveratrol and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related mouse phenotypes are skeleton and embryogenesis.

Aliases & Classifications for Progesterone-Receptor Negative Breast Cancer

Sources:
8Disease Ontology
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

progesterone-receptor negative breast cancer 8


External Ids:

Disease Ontology8 DOID:0060078

Related Diseases for Progesterone-Receptor Negative Breast Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Progesterone-Receptor Negative Breast Cancer family:

progesterone-receptor positive breast cancer

Diseases related to Progesterone-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1progesterone resistance30.5ESR1, PGR
2estrogen-receptor negative breast cancer10.6
3estrogen-receptor positive breast cancer10.3
4progesterone-receptor positive breast cancer10.3
5oral cancer10.3
6estrogen resistance10.3
7papilloma10.0RASSF1
8myeloma10.0CCND2
9uterine carcinosarcoma10.0ERBB2
10uterine sarcoma10.0ESR1
11pituitary tumors10.0ESR1
12cerebral meningioma10.0PGR
13malignant mesothelioma10.0RASSF1
14leukoplakia10.0RARB
15nasopharynx carcinoma10.0RASSF1
16myeloid leukemia10.0RARB
17sertoli-leydig cell tumor10.0PGR
18colon adenocarcinoma10.0RARB
19sarcoma10.0CCND2, TWIST1
20wilms tumor10.0RASSF1, CCND2
21laryngeal carcinoma10.0EGFR
22seminoma10.0RASSF1, CCND2
23esophageal cancer10.0EGFR
24kidney cancer10.0EGFR
25thyroid cancer10.0RARB, RASSF1
26breast fibroadenoma10.0PGR, ESR1
27leiomyoma10.0PGR, ESR1
28bilateral breast cancer10.0PGR, ESR1
29rhabdomyosarcoma10.0CCND2, RARB
30myoma10.0PGR, ESR1
31gynecomastia10.0ESR1, PGR
32melanoma10.0RARB, RASSF1
33leukemia10.0CCND2, RARB
34cribriform carcinoma10.0PGR, ESR1
35meningioma10.0PGR, ESR1
36angiomyolipoma10.0PGR, ESR1
37cholangiocarcinoma10.0RASSF1, ERBB2
38adenosarcoma10.0ESR1, PGR
39lichen sclerosus10.0RARB
40endometrial stromal sarcoma10.0PGR, ESR1
41endometriosis10.0ESR1, PGR
42ovarian cancer10.0PGR, ERBB2
43malignant mixed mullerian tumor10.0ERBB2, PGR
44familial adenomatous polyposis10.0RARB, RASSF1
45ependymoma10.0RASSF1, EGFR
46adenoid cystic carcinoma10.0ERBB2, RASSF1
47osteosarcoma10.0TWIST1, CCND2, ESR1
48leiomyomatosis10.0ESR1, PGR
49anaplastic astrocytoma10.0CCND2, EGFR
50bladder carcinoma10.0RASSF1, ERBB2

Graphical network of the top 20 diseases related to Progesterone-Receptor Negative Breast Cancer:



Diseases related to progesterone-receptor negative breast cancer

Clinical Features for Progesterone-Receptor Negative Breast Cancer

Drugs & Therapeutics for Progesterone-Receptor Negative Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Progesterone-Receptor Negative Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Progesterone-Receptor Negative Breast Cancer

Search NIH Clinical Center for Progesterone-Receptor Negative Breast Cancer

Search CenterWatch for Progesterone-Receptor Negative Breast Cancer

Genetic Tests for Progesterone-Receptor Negative Breast Cancer

Anatomical Context for Progesterone-Receptor Negative Breast Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Progesterone-Receptor Negative Breast Cancer:

33
Skin, Breast, T cells, B cells

Animal Models for Progesterone-Receptor Negative Breast Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Progesterone-Receptor Negative Breast Cancer

Sources:
51PubMed
See all sources

Articles related to Progesterone-Receptor Negative Breast Cancer:

(show all 21)
idTitleAuthorsYear
1
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. (23971947)
2013
2
Study of Estrogen Receptor and Progesterone Receptor Expression in Breast Ductal Carcinoma In Situ by Immunohistochemical Staining in ER/PgR-Negative Invasive Breast Cancer. (22091428)
2011
3
Oral contraceptive use and estrogen/progesterone receptor-negative breast cancer among African American women. (20647407)
2010
4
Activity of ixabepilone in oestrogen receptor-negative and oestrogen receptor-progesterone receptor-human epidermal growth factor receptor 2-negative metastatic breast cancer. (19683429)
2009
5
Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer. (19620495)
2009
6
Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. (18424605)
2008
7
Clinicopathological characteristics and prognostic factors of breast cancer with estrogen- and progesterone-receptor negative and HER-2 overexpression]. (19173993)
2008
8
The role of human epidermal growth factor receptor 2 in the survival of women with estrogen and progesterone receptor-negative, invasive breast cancer: the California Cancer Registry, 1999-2004. (18189290)
2008
9
Combined paclitaxel and cetuximab achieved a major response on the skin metastases of a patient with epidermal growth factor receptor-positive, estrogen receptor-negative, progesterone receptor-negative and human epidermal growth factor receptor-2-negative (triple-negative) breast cancer. (17581308)
2007
10
Transgenic introduction of androgen receptor into estrogen-receptor-, progesterone-receptor-, and androgen-receptor-negative breast cancer cells renders them responsive to hormonal manipulation. (16647340)
2006
11
Presence of erbB2 mRNA in the plasma of breast cancer patients is associated with circulating tumor cells and negative estrogen and progesterone receptor status. (16319978)
2006
12
Estrogen receptor alpha-negative and progesterone receptor-positive breast cancer: lab error or real entity? (17189985)
2006
13
Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance. (16145046)
2005
14
Estrogen receptor/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women. (15041725)
2004
15
Natural history of estrogen receptor-negative, progesterone receptor-positive breast cancer. (12408471)
2002
16
Microsatellite instability correlates with negative expression of estrogen and progesterone receptors in sporadic breast cancer. (10992275)
2000
17
Prognosis prediction of S-phase fraction and p53, c-erbB-2, estrogen receptor, progesterone receptor in axillary node-negative breast cancer]. (10678068)
1997
18
Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers. (9570382)
1997
19
Sequence variants of the estrogen receptor (ER) gene found in breast cancer patients with ER negative and progesterone receptor positive tumors. (8973592)
1996
20
High dose toremifene for estrogen and progesterone receptor negative metastatic breast cancer: a phase II trial of the Cancer and Leukemia Group B (CALGB). (7579504)
1995
21
Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line. (3702420)
1986

Genetic Variations for Progesterone-Receptor Negative Breast Cancer

Expression for genes affiliated with Progesterone-Receptor Negative Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Progesterone-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Progesterone-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Progesterone-Receptor Negative Breast Cancer

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 52QIAGEN
See all sources

Pathways related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7CCND2
29.6RASSF1, EGFR
3
Hide members
9.5EGFR, ERBB2
49.5ERBB2, EGFR
59.5ERBB2, EGFR
69.2PGR, CCND2
7
Hide members
8.9PGR, RARB, ESR1
8
Hide members
8.9EGFR, ERBB2, ESR1
9
Development Ligand-independent activation of ESR1 and ESR2
Hide members
8.9EGFR, ERBB2, ESR1
10
Hide members
8.7ERBB2, EGFR, CCND2
11
Cell cycle Cell cycle (generic schema)
Hide members
8.6ESR1, PGR, CCND2
128.6EGFR, RASSF1, RARB, ERBB2
13
Hide members
8.6ESR1, ERBB2, CCND2
14
Development Prolactin receptor signaling
Hide members
8.6ESR1, ERBB2, CCND2
158.5TWIST1, ESR1, ERBB2, EGFR
16
Hide members
8.5ESR1, ERBB2, PGR, EGFR
178.4EGFR, RARB, ERBB2, ESR1
188.3ERBB2, RASSF1, EGFR, CCND2
19
Hide members
7.5CCND2, EGFR, RARB, ERBB2, ESR1

Compounds for genes affiliated with Progesterone-Receptor Negative Breast Cancer

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1resveratrol45 60 11 2413.0ERBB2, PGR
2ici 164384459.8ESR1, PGR
3Ethynodiol Diacetate119.8PGR, ESR1
4Allylestrenol119.8ESR1, PGR
5Etonogestrel119.8PGR, ESR1
6Afatinib119.8EGFR, ERBB2
7idoxifene459.8ESR1, PGR
8iressa609.8ERBB2, EGFR
9ag 1478 hydrochloride609.8ERBB2, EGFR
10ag 490609.7ERBB2, EGFR
11triphenylethylene459.7PGR, ESR1
12jnj 28871063 hydrochloride609.7EGFR, ERBB2
13pd158780459.7ERBB2, EGFR
14pertuzumab45 50 1111.6ERBB2, EGFR
15fadrozole459.6ERBB2, ESR1
16pki-166459.5ERBB2, EGFR
17capecitabine45 50 1111.5PGR, ERBB2, EGFR
18leucovorin45 50 1111.4ERBB2, PGR, EGFR
19megestrol acetate459.4PGR, ESR1, ERBB2
20toremifene45 1110.4PGR, ESR1, ERBB2
21norgestimate45 1110.3PGR, ESR1
22raloxifene45 29 50 1112.3PGR, ERBB2, ESR1
23hrgbeta1459.2EGFR, ERBB2
24n-(4-hydroxyphenyl)retinamide459.2RARB, ESR1, ERBB2
25gefitinib45 50 1111.0ESR1, ERBB2, EGFR
26anastrozole45 119.9ESR1, ERBB2, PGR, EGFR
27exemestane50 45 60 1111.9ESR1, EGFR, PGR, ERBB2
28lapatinib45 50 1110.9ESR1, EGFR, PGR, ERBB2
29fulvestrant45 50 29 1111.9EGFR, PGR, ESR1, ERBB2
30letrozole45 50 60 1111.9EGFR, ESR1, PGR, ERBB2
31taxane458.9PGR, EGFR, ESR1, ERBB2
32trastuzumab45 50 1110.9ESR1, ERBB2, PGR, EGFR
334-hydroxytamoxifen458.9ERBB2, EGFR, ESR1, PGR
34paclitaxel45 50 1110.9ESR1, ERBB2, PGR, EGFR
35progestin458.9PGR, ESR1, ERBB2, EGFR
36geldanamycin45 50 60 1111.9ERBB2, PGR, EGFR, ESR1
37docetaxel45 50 60 1111.9PGR, EGFR, ERBB2, ESR1
385fluorouracil458.8PGR, ERBB2, EGFR, ESR1
39tamoxifen45 50 29 1111.8ESR1, PGR, EGFR, ERBB2
40retinoid458.8PGR, ESR1, RARB, EGFR
41agar458.6RASSF1, EGFR, PGR, RARB, ERBB2
42paraffin458.5PGR, EGFR, ESR1, ERBB2
43genistein45 29 60 2 11 2413.3ESR1, ERBB2, RARB, PGR, EGFR
44testosterone45 60 11 2411.3ERBB2, EGFR, PGR, ESR1, RARB
45estradiol45 11 2410.2RARB, CCND2, ESR1, PGR
465-aza-2deoxycytidine458.2RASSF1, ESR1, RARB, PGR, CCND2
47cisplatin45 50 60 1111.2ERBB2, RARB, EGFR, CCND2, RASSF1
48doxorubicin45 50 1110.1ERBB2, PGR, EGFR, CCND2, ESR1
49retinoic acid45 248.6ESR1, CCND2, EGFR, PGR, RASSF1, RARB
50progesterone45 60 29 11 2411.6ESR1, PGR, CCND2, EGFR, RARB, ERBB2

GO Terms for genes affiliated with Progesterone-Receptor Negative Breast Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.4TWIST1, ESR1, ERBB2, RARB, RASSF1, PGR

Biological processes related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1embryonic hindlimb morphogenesisGO:0351169.5RARB, TWIST1
2positive regulation of MAP kinase activityGO:0434069.5ERBB2, EGFR
3cellular response to estradiol stimulusGO:0713929.5ESR1, EGFR
4positive regulation of nitric oxide biosynthetic processGO:0454299.3EGFR, ESR1
5transcription initiation from RNA polymerase II promoterGO:0063679.0PGR, RARB, ESR1
6positive regulation of fibroblast proliferationGO:0481469.0ESR1, EGFR
7positive regulation of protein phosphorylationGO:0019348.9ERBB2, EGFR, CCND2
8positive regulation of transcription from RNA polymerase II promoterGO:0459448.5TWIST1, ESR1, RARB, EGFR
9signal transductionGO:0071658.1EGFR, PGR, RARB, ERBB2, ESR1

Molecular functions related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.7ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.6ERBB2, EGFR
3transmembrane receptor protein tyrosine kinase activityGO:0047149.5ERBB2, EGFR
4nitric-oxide synthase regulator activityGO:0302359.5EGFR, ESR1
5steroid bindingGO:0054969.3ESR1, PGR
6steroid hormone receptor activityGO:0037079.1ESR1, RARB, PGR
7enzyme bindingGO:0198998.6ESR1, PGR, EGFR
8identical protein bindingGO:0428028.5EGFR, RASSF1, ERBB2, ESR1
9protein bindingGO:0055156.5CCND2, EGFR, PGR, RASSF1, RARB, ERBB2

Products for genes affiliated with Progesterone-Receptor Negative Breast Cancer

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  • Proteins
  • Lysates
  • Antibodies

Sources for Progesterone-Receptor Negative Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet