MCID: PRG003
MIFTS: 40

Progesterone-Receptor Negative Breast Cancer malady

Cancer diseases category

Summaries for Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Progesterone-Receptor Negative Breast Cancer is related to breast cancer and estrogen-receptor negative breast cancer. An important gene associated with Progesterone-Receptor Negative Breast Cancer is TWIST1 (twist basic helix-loop-helix transcription factor 1), and among its related pathways are Glioma and G-protein signaling K-RAS regulation pathway. The compounds resveratrol and ici 164384 have been mentioned in the context of this disorder. Affiliated tissues include breast and skin, and related mouse phenotypes are skeleton and embryogenesis.

Aliases & Classifications for Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
8Disease Ontology
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

progesterone-receptor negative breast cancer 8


External Ids:

Disease Ontology8 DOID:0060078

Related Diseases for Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Progesterone-Receptor Negative Breast Cancer family:

Progesterone-Receptor Positive Breast Cancer

Diseases related to Progesterone-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.8CCND2, EGFR, PGR, RASSF1, RARB, ERBB2
2estrogen-receptor negative breast cancer10.5
3estrogen-receptor positive breast cancer10.3
4progesterone-receptor positive breast cancer10.3
5papilloma10.0RASSF1
6myeloma10.0CCND2
7uterine carcinosarcoma10.0ERBB2
8uterine sarcoma10.0ESR1
9pituitary tumors10.0ESR1
10cerebral meningioma10.0PGR
11malignant mesothelioma10.0RASSF1
12leukoplakia10.0RARB
13nasopharynx carcinoma10.0RASSF1
14myeloid leukemia10.0RARB
15sertoli-leydig cell tumor10.0PGR
16sarcoma10.0TWIST1, CCND2
17colon adenocarcinoma10.0RARB
18wilms tumor10.0RASSF1, CCND2
19laryngeal benign neoplasm10.0EGFR
20seminoma10.0RASSF1, CCND2
21esophageal cancer10.0EGFR
22kidney cancer10.0EGFR
23thyroid cancer10.0RARB, RASSF1
24breast fibroadenoma10.0ESR1, PGR
25leiomyoma10.0ESR1, PGR
26bilateral breast cancer10.0ESR1, PGR
27rhabdomyosarcoma10.0RARB, CCND2
28myoma10.0ESR1, PGR
29gynecomastia10.0PGR, ESR1
30melanoma10.0RARB, RASSF1
31leukemia10.0RARB, CCND2
32meningioma10.0PGR, ESR1
33progesterone resistance10.0PGR, ESR1
34cribriform carcinoma10.0PGR, ESR1
35angiomyolipoma10.0ESR1, PGR
36cholangiocarcinoma10.0ERBB2, RASSF1
37lichen sclerosus10.0RARB
38adenosarcoma10.0ESR1, PGR
39endometrial stromal sarcoma10.0ESR1, PGR
40endometriosis10.0ESR1, PGR
41malignant mixed mullerian tumor10.0ERBB2, PGR
42familial adenomatous polyposis10.0RARB, RASSF1
43ependymoma10.0EGFR, RASSF1
44adenoid cystic carcinoma10.0ERBB2, RASSF1
45osteosarcoma10.0TWIST1, ESR1, CCND2
46leiomyomatosis10.0ESR1, PGR
47bladder carcinoma10.0RASSF1, ERBB2
48anaplastic astrocytoma10.0EGFR, CCND2
49cervical adenocarcinoma10.0PGR, RASSF1, ESR1
50hepatocellular carcinoma10.0RASSF1, RARB, TWIST1

Graphical network of the top 20 diseases related to Progesterone-Receptor Negative Breast Cancer:



Diseases related to progesterone-receptor negative breast cancer

Clinical Features for Progesterone-Receptor Negative Breast Cancer

About this section

Drugs & Therapeutics for Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Progesterone-Receptor Negative Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Progesterone-Receptor Negative Breast Cancer

Search NIH Clinical Center for Progesterone-Receptor Negative Breast Cancer

Search CenterWatch for Progesterone-Receptor Negative Breast Cancer

Genetic Tests for Progesterone-Receptor Negative Breast Cancer

About this section

Anatomical Context for Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Progesterone-Receptor Negative Breast Cancer:

32
Breast, Skin

Animal Models for Progesterone-Receptor Negative Breast Cancer or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Progesterone-Receptor Negative Breast Cancer:

36 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.0TWIST1, PGR
2MP:00053809.5PGR, ERBB2, TWIST1
3MP:00036319.5ERBB2, RARB
4MP:00053799.4RARB, CCND2
5MP:00053699.3RARB, ESR1, TWIST1
6MP:00053828.6TWIST1, ERBB2, RARB, EGFR
7MP:00053898.3ERBB2, RARB, EGFR, CCND2
8MP:00053768.3ESR1, PGR, CCND2
9MP:00020068.3EGFR, PGR, RASSF1, ERBB2, ESR1
10MP:00053818.2EGFR, RARB, ERBB2, ESR1, TWIST1
11MP:00028738.1EGFR, PGR, RASSF1, RARB, ERBB2
12MP:00053867.4CCND2, PGR, RARB, ERBB2, ESR1, TWIST1
13MP:00053877.3CCND2, EGFR, PGR, RASSF1, RARB, ESR1
14MP:00053847.1CCND2, EGFR, PGR, RASSF1, ERBB2, ESR1
15MP:00053856.7TWIST1, CCND2, EGFR, PGR, RASSF1, RARB
16MP:00107686.7CCND2, EGFR, PGR, RASSF1, RARB, ERBB2

Publications for Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
50PubMed
See all sources

Articles related to Progesterone-Receptor Negative Breast Cancer:

(show all 21)
idTitleAuthorsYear
1
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. (23971947)
2013
2
Study of Estrogen Receptor and Progesterone Receptor Expression in Breast Ductal Carcinoma In Situ by Immunohistochemical Staining in ER/PgR-Negative Invasive Breast Cancer. (22091428)
2011
3
Oral contraceptive use and estrogen/progesterone receptor-negative breast cancer among African American women. (20647407)
2010
4
Activity of ixabepilone in oestrogen receptor-negative and oestrogen receptor-progesterone receptor-human epidermal growth factor receptor 2-negative metastatic breast cancer. (19683429)
2009
5
Nuclear detection of Y-box protein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer. (19930682)
2009
6
Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. (18424605)
2008
7
Clinicopathological characteristics and prognostic factors of breast cancer with estrogen- and progesterone-receptor negative and HER-2 overexpression]. (19173993)
2008
8
The role of human epidermal growth factor receptor 2 in the survival of women with estrogen and progesterone receptor-negative, invasive breast cancer: the California Cancer Registry, 1999-2004. (18189290)
2008
9
Combined paclitaxel and cetuximab achieved a major response on the skin metastases of a patient with epidermal growth factor receptor-positive, estrogen receptor-negative, progesterone receptor-negative and human epidermal growth factor receptor-2-negative (triple-negative) breast cancer. (17581308)
2007
10
Transgenic introduction of androgen receptor into estrogen-receptor-, progesterone-receptor-, and androgen-receptor-negative breast cancer cells renders them responsive to hormonal manipulation. (16647340)
2006
11
Presence of erbB2 mRNA in the plasma of breast cancer patients is associated with circulating tumor cells and negative estrogen and progesterone receptor status. (16319978)
2006
12
Estrogen receptor alpha-negative and progesterone receptor-positive breast cancer: lab error or real entity? (17189985)
2006
13
Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance. (16145046)
2005
14
Estrogen receptor/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women. (15041725)
2004
15
Natural history of estrogen receptor-negative, progesterone receptor-positive breast cancer. (12408471)
2002
16
Microsatellite instability correlates with negative expression of estrogen and progesterone receptors in sporadic breast cancer. (10992275)
2000
17
Prognosis prediction of S-phase fraction and p53, c-erbB-2, estrogen receptor, progesterone receptor in axillary node-negative breast cancer]. (10678068)
1997
18
Estrogen receptor-negative/progesterone receptor-positive Evsa-T mammary tumor cells: a model for assessing the biological property of this peculiar phenotype of breast cancers. (9570382)
1997
19
Sequence variants of the estrogen receptor (ER) gene found in breast cancer patients with ER negative and progesterone receptor positive tumors. (8973592)
1996
20
High dose toremifene for estrogen and progesterone receptor negative metastatic breast cancer: a phase II trial of the Cancer and Leukemia Group B (CALGB). (7579504)
1995
21
Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line. (3702420)
1986

Genetic Variations for Progesterone-Receptor Negative Breast Cancer

About this section

Expression for genes affiliated with Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Progesterone-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Progesterone-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN
See all sources

Pathways related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7CCND2
29.6RASSF1, EGFR
3
Hide members
9.5EGFR, ERBB2
49.5ERBB2, EGFR
59.5ERBB2, EGFR
69.2PGR, CCND2
7
Hide members
8.9PGR, RARB, ESR1
8
Hide members
8.9EGFR, ERBB2, ESR1
9
Development Ligand-independent activation of ESR1 and ESR2
Hide members
8.9EGFR, ERBB2, ESR1
10
Hide members
8.7ERBB2, EGFR, CCND2
11
Cell cycle Cell cycle (generic schema)
Hide members
8.6ESR1, PGR, CCND2
128.6EGFR, RASSF1, RARB, ERBB2
13
Hide members
8.6ESR1, ERBB2, CCND2
14
Development Prolactin receptor signaling
Hide members
8.6ESR1, ERBB2, CCND2
158.5TWIST1, ESR1, ERBB2, EGFR
16
Hide members
8.5ESR1, ERBB2, PGR, EGFR
178.4EGFR, RARB, ERBB2, ESR1
188.3ERBB2, RASSF1, EGFR, CCND2
19
Hide members
7.5CCND2, EGFR, RARB, ERBB2, ESR1

Compounds for genes affiliated with Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1resveratrol44 59 11 2413.0ERBB2, PGR
2ici 164384449.8ESR1, PGR
3Ethynodiol Diacetate119.8ESR1, PGR
4Afatinib119.8EGFR, ERBB2
5Allylestrenol119.8PGR, ESR1
6Etonogestrel119.8PGR, ESR1
7idoxifene449.8PGR, ESR1
8jnj 28871063 hydrochloride599.8EGFR, ERBB2
9ag 490599.8EGFR, ERBB2
10ag 1478 hydrochloride599.7EGFR, ERBB2
11triphenylethylene449.7PGR, ESR1
12iressa599.7EGFR, ERBB2
13pd158780449.7EGFR, ERBB2
14pertuzumab44 49 1111.6EGFR, ERBB2
15fadrozole449.6ERBB2, ESR1
16pki-166449.5ERBB2, EGFR
17capecitabine44 49 1111.5ERBB2, PGR, EGFR
18leucovorin44 49 1111.4EGFR, PGR, ERBB2
19megestrol acetate449.4PGR, ERBB2, ESR1
20toremifene44 1110.4PGR, ERBB2, ESR1
21norgestimate44 1110.3PGR, ESR1
22raloxifene44 28 49 1112.3PGR, ERBB2, ESR1
23hrgbeta1449.2ERBB2, EGFR
24n-(4-hydroxyphenyl)retinamide449.2ESR1, ERBB2, RARB
25gefitinib44 49 1111.0ESR1, ERBB2, EGFR
26anastrozole44 119.9ESR1, ERBB2, PGR, EGFR
27exemestane49 44 59 1111.9EGFR, PGR, ERBB2, ESR1
28lapatinib44 49 1110.9EGFR, PGR, ERBB2, ESR1
29fulvestrant44 49 28 1111.9EGFR, PGR, ERBB2, ESR1
30letrozole44 49 59 1111.9EGFR, PGR, ERBB2, ESR1
31taxane448.9EGFR, PGR, ERBB2, ESR1
32trastuzumab44 49 1110.9EGFR, PGR, ERBB2, ESR1
334-hydroxytamoxifen448.9ESR1, ERBB2, PGR, EGFR
34paclitaxel44 49 1110.9EGFR, PGR, ERBB2, ESR1
35progestin448.9EGFR, PGR, ERBB2, ESR1
36geldanamycin44 49 59 1111.9ESR1, ERBB2, PGR, EGFR
37docetaxel44 49 59 1111.9ESR1, ERBB2, PGR, EGFR
385fluorouracil448.8EGFR, PGR, ERBB2, ESR1
39tamoxifen44 49 28 1111.8ESR1, ERBB2, PGR, EGFR
40retinoid448.8ESR1, RARB, PGR, EGFR
41agar448.6EGFR, PGR, RASSF1, RARB, ERBB2
42paraffin448.5EGFR, PGR, ERBB2, ESR1
43genistein44 28 59 2 11 2413.3EGFR, PGR, RARB, ERBB2, ESR1
44testosterone44 59 11 2411.3EGFR, PGR, RARB, ERBB2, ESR1
45estradiol44 11 2410.2CCND2, PGR, RARB, ESR1
465-aza-2deoxycytidine448.2CCND2, PGR, RASSF1, RARB, ESR1
47cisplatin44 49 59 1111.2CCND2, EGFR, RASSF1, RARB, ERBB2
48doxorubicin44 49 1110.1CCND2, EGFR, PGR, ERBB2, ESR1
49retinoic acid44 248.6ESR1, RARB, RASSF1, PGR, EGFR, CCND2
50progesterone44 59 28 11 2411.6CCND2, EGFR, PGR, RARB, ERBB2, ESR1

GO Terms for genes affiliated with Progesterone-Receptor Negative Breast Cancer

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.4TWIST1, ESR1, ERBB2, RARB, RASSF1, PGR

Biological processes related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1embryonic hindlimb morphogenesisGO:0351169.5RARB, TWIST1
2positive regulation of MAP kinase activityGO:0434069.5ERBB2, EGFR
3cellular response to estradiol stimulusGO:0713929.5ESR1, EGFR
4positive regulation of nitric oxide biosynthetic processGO:0454299.3EGFR, ESR1
5transcription initiation from RNA polymerase II promoterGO:0063679.0PGR, RARB, ESR1
6positive regulation of fibroblast proliferationGO:0481469.0ESR1, EGFR
7positive regulation of protein phosphorylationGO:0019348.9ERBB2, EGFR, CCND2
8positive regulation of transcription from RNA polymerase II promoterGO:0459448.5TWIST1, ESR1, RARB, EGFR
9signal transductionGO:0071658.1EGFR, PGR, RARB, ERBB2, ESR1

Molecular functions related to Progesterone-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.7ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.6ERBB2, EGFR
3transmembrane receptor protein tyrosine kinase activityGO:0047149.5ERBB2, EGFR
4nitric-oxide synthase regulator activityGO:0302359.5EGFR, ESR1
5steroid bindingGO:0054969.3ESR1, PGR
6steroid hormone receptor activityGO:0037079.1ESR1, RARB, PGR
7enzyme bindingGO:0198998.6ESR1, PGR, EGFR
8identical protein bindingGO:0428028.5EGFR, RASSF1, ERBB2, ESR1
9protein bindingGO:0055156.5CCND2, EGFR, PGR, RASSF1, RARB, ERBB2

Products for genes affiliated with Progesterone-Receptor Negative Breast Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Progesterone-Receptor Negative Breast Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet