MCID: PRG002
MIFTS: 31

Progesterone-Receptor Positive Breast Cancer malady

Cancer diseases category

Summaries for Progesterone-Receptor Positive Breast Cancer

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MalaCards based summary: Progesterone-Receptor Positive Breast Cancer is related to breast cancer and cerebral meningioma. An important gene associated with Progesterone-Receptor Positive Breast Cancer is PGR (progesterone receptor), and among its related pathways are Chronic myeloid leukemia and HIF-1 signaling pathway. The compounds ici 164384 and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include breast and endothelial, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Aliases & Classifications for Progesterone-Receptor Positive Breast Cancer

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Progesterone-Receptor Positive Breast Cancer, Aliases & Descriptions:

Name: Progesterone-Receptor Positive Breast Cancer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:0060077

Related Diseases for Progesterone-Receptor Positive Breast Cancer

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Diseases in the Progesterone-Receptor Positive Breast Cancer family:

Progesterone-Receptor Negative Breast Cancer

Diseases related to Progesterone-Receptor Positive Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.6VEGFA, PGR, ESR1, ERBB2
2cerebral meningioma10.4PGR
3endotheliitis10.4
4malignant mixed mullerian tumor10.1ERBB2, PGR
5cribriform carcinoma10.0PGR, ESR1
6progesterone resistance10.0PGR, ESR1
7meningioma, familial10.0PGR, ESR1
8bilateral breast cancer10.0ESR1, PGR
9adenosarcoma10.0ESR1, PGR
10leiomyomatosis10.0PGR, ESR1
11myoma10.0PGR, ESR1
12endometrial stromal sarcoma10.0PGR, ESR1
13lymphangioleiomyomatosis10.0ESR1, PGR
14angiomyolipoma10.0PGR, ESR1
15cervical adenocarcinoma10.0PGR, ESR1
16gynecomastia10.0ESR1, PGR
17lung cancer10.0ERBB2, VEGFA
18lung cancer susceptibility 310.0ERBB2, VEGFA
19smooth muscle tumor10.0PGR, ESR1
20uterine fibroid9.9ESR1, PGR
21leiomyoma9.9ESR1, PGR
22squamous cell carcinoma, head and neck9.9VEGFA, ERBB2
23endometriosis9.8VEGFA, ESR1, PGR
24mammary paget's disease9.8ERBB2, ESR1, PGR
25breast disease9.8PGR, ERBB2, ESR1
26inflammatory breast carcinoma9.8ESR1, ERBB2, PGR
27ductal carcinoma in situ9.8ESR1, ERBB2, PGR
28tubular adenocarcinoma9.8ERBB2, ESR1, PGR
29breast ductal carcinoma9.8ESR1, PGR, ERBB2
30breast fibroadenoma9.8PGR, ERBB2, ESR1
31li-fraumeni syndrome9.8ESR1, ERBB2, PGR
32factor vii deficiency9.8VEGFA, ESR1, ERBB2
33papillary carcinoma9.8ESR1, PGR, ERBB2
34endometrial cancer9.8PGR, ESR1, ERBB2
35vascular disease9.7ESR1, VEGFA
36prostate cancer9.6ERBB2, ESR1, VEGFA
37ovarian cancer, somatic9.5PGR, VEGFA, ERBB2, ESR1
38adenocarcinoma9.5ESR1, ERBB2, VEGFA, PGR

Graphical network of the top 20 diseases related to Progesterone-Receptor Positive Breast Cancer:



Diseases related to progesterone-receptor positive breast cancer

Symptoms for Progesterone-Receptor Positive Breast Cancer

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Drugs & Therapeutics for Progesterone-Receptor Positive Breast Cancer

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Drug clinical trials:

Search ClinicalTrials for Progesterone-Receptor Positive Breast Cancer

Search NIH Clinical Center for Progesterone-Receptor Positive Breast Cancer

Genetic Tests for Progesterone-Receptor Positive Breast Cancer

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Anatomical Context for Progesterone-Receptor Positive Breast Cancer

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MalaCards organs/tissues related to Progesterone-Receptor Positive Breast Cancer:

31
Breast, Endothelial

Animal Models for Progesterone-Receptor Positive Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Progesterone-Receptor Positive Breast Cancer:

35 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6ESR1, PGR, VEGFA
2MP:00053888.4VEGFA, ESR1, ERBB2
3MP:00053718.3ERBB2, ESR1, PGR, VEGFA
4MP:00020068.3VEGFA, PGR, ESR1, ERBB2
5MP:00053698.3ERBB2, ESR1, PGR, VEGFA
6MP:00053798.3VEGFA, PGR, ESR1, ERBB2
7MP:00053908.2ERBB2, ESR1, PGR, VEGFA
8MP:00107718.2VEGFA, PGR, ESR1, ERBB2
9MP:00053818.2ERBB2, ESR1, VEGFA
10MP:00053808.2ERBB2, ESR1, PGR, VEGFA
11MP:00053898.2VEGFA, PGR, ESR1, ERBB2
12MP:00053858.2ERBB2, ESR1, PGR, VEGFA
13MP:00053868.1VEGFA, PGR, ESR1, ERBB2
14MP:00053848.1ERBB2, ESR1, PGR, VEGFA
15MP:00053768.1VEGFA, PGR, ESR1, ERBB2
16MP:00107688.0ERBB2, ESR1, PGR, VEGFA

Publications for Progesterone-Receptor Positive Breast Cancer

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Articles related to Progesterone-Receptor Positive Breast Cancer:

(show all 14)
idTitleAuthorsYear
1
Clinical significance of SPRR1A expression in progesterone receptor-positive breast cancer. (25424702)
2015
2
Randomized phase II study of lonaprisan as second-line therapy for progesterone receptor-positive breast cancer. (23788750)
2013
3
Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer. (23579222)
2013
4
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. (23971947)
2013
5
A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study. (22548922)
2012
6
Progesterone and levonorgestrel regulate expression of 17I^HSD-enzymes in progesterone receptor positive breast cancer cell line T47D. (22564730)
2012
7
Pilot trial of preoperative (neoadjuvant) letrozole in combination with bevacizumab in postmenopausal women with newly diagnosed estrogen receptor- or progesterone receptor-positive breast cancer. (20705559)
2010
8
Shorter survival-times following adjuvant endocrine therapy in oestrogen- and progesterone-receptor positive breast cancer overexpressing HER2 and/or with an increased expression of vascular endothelial growth factor. (19130322)
2009
9
Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer? (19703124)
2009
10
Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy. (18302747)
2008
11
Is there a role for adjuvant tamoxifen in progesterone receptor-positive breast cancer? An in silico clinical trial. (16467123)
2006
12
Estrogen receptor alpha-negative and progesterone receptor-positive breast cancer: lab error or real entity? (17189985)
2006
13
Natural history of estrogen receptor-negative, progesterone receptor-positive breast cancer. (12408471)
2002
14
Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group. (9196144)
1997

Variations for Progesterone-Receptor Positive Breast Cancer

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Expression for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Search GEO for disease gene expression data for Progesterone-Receptor Positive Breast Cancer.

Pathways for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Pathways related to Progesterone-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3VEGFA, ERBB2
29.3ERBB2, VEGFA
3
Show member pathways
Signaling Pathways in Glioblastoma36
9.3ERBB2, VEGFA
4
Show member pathways
Nuclear Receptors36
9.1PGR, ESR1
5
Show member pathways
9.1ESR1, PGR
6
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.1ESR1, PGR
79.1ESR1, VEGFA
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.1ESR1, VEGFA
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
9.1ESR1, VEGFA
10
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.0ERBB2, ESR1
11
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.0ERBB2, ESR1
12
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.0ESR1, ERBB2
13
Show member pathways
8.5ERBB2, ESR1, PGR
148.5ERBB2, ESR1, VEGFA
158.5VEGFA, ESR1, ERBB2
16
Show member pathways
8.0VEGFA, PGR, ESR1, ERBB2

Compounds for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Compounds related to Progesterone-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1ici 164384439.5ESR1, PGR
2idoxifene439.5ESR1, PGR
3triphenylethylene439.5ESR1, PGR
4norgestimate43 1210.4ESR1, PGR
5medroxyprogesterone43 49 28 24 1213.4ESR1, PGR
6trilostane43 1210.4PGR, ESR1
7nandrolone43 2410.4ESR1, PGR
8estradiol benzoate439.4ESR1, PGR
9droloxifene439.4ESR1, PGR
10fadrozole439.3ESR1, ERBB2
11onapristone43 2810.3ESR1, PGR
12desogestrel43 1210.2ESR1, PGR
13capecitabine43 49 1211.2VEGFA, PGR, ERBB2
14goserelin43 28 1211.2PGR, ESR1
15leucovorin43 49 1211.2ERBB2, PGR, VEGFA
16nomegestrol acetate439.1ESR1, PGR
17bisphenol a439.1ESR1, PGR
18leuprolide acetate439.0ESR1, PGR
19mifepristone43 28 59 1211.9VEGFA, PGR, ESR1
20megestrol acetate438.9ERBB2, ESR1, PGR
21anastrozole43 49 1210.9PGR, ESR1, ERBB2
22exemestane43 49 59 1211.9PGR, ESR1, ERBB2
23everolimus43 49 1210.9VEGFA, ESR1, ERBB2
24lapatinib43 49 1210.9ERBB2, ESR1, PGR
25toremifene43 129.9PGR, ESR1, ERBB2
26fulvestrant43 49 28 1211.9ERBB2, ESR1, PGR
27letrozole43 49 59 1211.9PGR, ESR1, ERBB2
28radicicol43 59 1210.9VEGFA, ESR1, ERBB2
29raloxifene43 49 28 1211.9PGR, ESR1, ERBB2
304-hydroxytamoxifen438.9ERBB2, ESR1, PGR
31gefitinib43 49 1210.9ERBB2, ESR1, VEGFA
323,3-diindolylmethane438.8ESR1, VEGFA
33gnrh438.7PGR, ESR1, ERBB2
34methotrexate49 43 1210.7ERBB2, ESR1, PGR
35taxane438.4ERBB2, ESR1, PGR, VEGFA
36trastuzumab43 49 1210.4VEGFA, PGR, ESR1, ERBB2
37progestin438.4VEGFA, PGR, ESR1, ERBB2
38geldanamycin43 49 59 1211.4ERBB2, ESR1, PGR, VEGFA
39resveratrol43 59 24 1211.4VEGFA, PGR, ESR1, ERBB2
40docetaxel43 49 59 1211.4ERBB2, ESR1, PGR, VEGFA
41cyclophosphamide43 49 1210.4VEGFA, PGR, ESR1, ERBB2
425fluorouracil438.4ERBB2, ESR1, PGR, VEGFA
43tamoxifen43 49 28 1211.4ERBB2, ESR1, PGR, VEGFA
44paclitaxel43 49 1210.4VEGFA, PGR, ESR1, ERBB2
45doxorubicin43 49 1210.4ERBB2, ESR1, PGR, VEGFA
46paraffin438.4VEGFA, PGR, ESR1, ERBB2
47genistein43 28 59 2 24 1213.4VEGFA, PGR, ESR1, ERBB2
48cycloheximide438.3VEGFA, PGR, ESR1, ERBB2
49vegf438.3ERBB2, ESR1, PGR, VEGFA
50estrogen438.3VEGFA, PGR, ESR1, ERBB2

GO Terms for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Biological processes related to Progesterone-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell adhesionGO:00457859.5ERBB2, VEGFA
2positive regulation of MAP kinase activityGO:00434069.4ERBB2, VEGFA
3positive regulation of epithelial cell proliferationGO:00506799.4ERBB2, VEGFA
4mammary gland alveolus developmentGO:00607499.3ESR1, VEGFA
5positive regulation of protein phosphorylationGO:00019349.2ERBB2, VEGFA
6negative regulation of gene expressionGO:00106299.1PGR, ESR1
7transcription initiation from RNA polymerase II promoterGO:00063679.1ESR1, PGR
8signal transductionGO:00071658.2ERBB2, ESR1, PGR

Molecular functions related to Progesterone-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:00037079.1ESR1, PGR
2steroid bindingGO:00054969.0ESR1, PGR
3identical protein bindingGO:00428028.2ERBB2, ESR1, VEGFA

Products for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Sources for Progesterone-Receptor Positive Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet