MCID: PRG002
MIFTS: 36

Progesterone-Receptor Positive Breast Cancer malady

Cancer diseases category
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Summaries for Progesterone-Receptor Positive Breast Cancer

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33MalaCards
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MalaCards: Progesterone-Receptor Positive Breast Cancer is related to breast cancer and cerebral meningioma. An important gene associated with Progesterone-Receptor Positive Breast Cancer is PGR (progesterone receptor), and among its related pathways are Glioma and HIF-1 signaling pathway. The compounds ici 164384 and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Aliases & Classifications for Progesterone-Receptor Positive Breast Cancer

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8Disease Ontology
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

progesterone-receptor positive breast cancer 8


External Ids:

Disease Ontology8 DOID:0060077

Related Diseases for Progesterone-Receptor Positive Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Progesterone-Receptor Positive Breast Cancer family:

Progesterone-Receptor Negative Breast Cancer

Diseases related to Progesterone-Receptor Positive Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.1VEGFA, PGR, ESR1, ERBB2
2cerebral meningioma10.1PGR
3malignant mixed mullerian tumor10.0ERBB2, PGR
4cribriform carcinoma10.0PGR, ESR1
5progesterone resistance10.0PGR, ESR1
6meningioma10.0PGR, ESR1
7bilateral breast cancer10.0ESR1, PGR
8adenosarcoma10.0ESR1, PGR
9leiomyomatosis10.0PGR, ESR1
10myoma10.0PGR, ESR1
11endometrial stromal sarcoma10.0PGR, ESR1
12lymphangioleiomyomatosis10.0ESR1, PGR
13angiomyolipoma10.0PGR, ESR1
14cervical adenocarcinoma10.0PGR, ESR1
15gynecomastia10.0ESR1, PGR
16non-small cell lung carcinoma10.0ERBB2, VEGFA
17lung adenocarcinoma10.0ERBB2, VEGFA
18smooth muscle tumor10.0PGR, ESR1
19uterine fibroid10.0ESR1, PGR
20leiomyoma10.0ESR1, PGR
21squamous cell carcinoma of the head and neck10.0VEGFA, ERBB2
22endometriosis10.0VEGFA, ESR1, PGR
23mammary paget's disease10.0ERBB2, ESR1, PGR
24male breast cancer10.0ERBB2, PGR, ESR1
25inflammatory breast carcinoma9.9ESR1, ERBB2, PGR
26breast cancer, invasive ductal9.9PGR, ESR1, ERBB2
27ductal carcinoma in situ9.9ESR1, ERBB2, PGR
28tubular adenocarcinoma9.9ERBB2, ESR1, PGR
29breast fibroadenoma9.9PGR, ERBB2, ESR1
30li-fraumeni syndrome9.9ESR1, ERBB2, PGR
31factor vii deficiency9.9VEGFA, ESR1, ERBB2
32papillary carcinoma9.9ESR1, PGR, ERBB2
33endometrial carcinoma9.9PGR, ESR1, ERBB2
34vascular disease9.9ESR1, VEGFA
35prostate cancer9.9ERBB2, ESR1, VEGFA
36ovarian cancer9.9PGR, VEGFA, ERBB2, ESR1
37adenocarcinoma9.9ESR1, ERBB2, VEGFA, PGR

Graphical network of the top 20 diseases related to Progesterone-Receptor Positive Breast Cancer:



Diseases related to progesterone-receptor positive breast cancer

Symptoms for Progesterone-Receptor Positive Breast Cancer

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Drugs & Therapeutics for Progesterone-Receptor Positive Breast Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Progesterone-Receptor Positive Breast Cancer

Search NIH Clinical Center for Progesterone-Receptor Positive Breast Cancer

Genetic Tests for Progesterone-Receptor Positive Breast Cancer

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Anatomical Context for Progesterone-Receptor Positive Breast Cancer

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33MalaCards
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MalaCards organs/tissues related to Progesterone-Receptor Positive Breast Cancer:

33
Breast

Animal Models for Progesterone-Receptor Positive Breast Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Progesterone-Receptor Positive Breast Cancer:

37 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6ESR1, PGR, VEGFA
2MP:00053888.4VEGFA, ESR1, ERBB2
3MP:00053718.3ERBB2, ESR1, PGR, VEGFA
4MP:00020068.3VEGFA, PGR, ESR1, ERBB2
5MP:00053698.3ERBB2, ESR1, PGR, VEGFA
6MP:00053798.3VEGFA, PGR, ESR1, ERBB2
7MP:00053908.2ERBB2, ESR1, PGR, VEGFA
8MP:00107718.2VEGFA, PGR, ESR1, ERBB2
9MP:00053818.2ERBB2, ESR1, VEGFA
10MP:00053808.2ERBB2, ESR1, PGR, VEGFA
11MP:00053898.2VEGFA, PGR, ESR1, ERBB2
12MP:00053858.2ERBB2, ESR1, PGR, VEGFA
13MP:00053868.1VEGFA, PGR, ESR1, ERBB2
14MP:00053848.1ERBB2, ESR1, PGR, VEGFA
15MP:00053768.1VEGFA, PGR, ESR1, ERBB2
16MP:00107688.0ERBB2, ESR1, PGR, VEGFA

Publications for Progesterone-Receptor Positive Breast Cancer

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52PubMed
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Articles related to Progesterone-Receptor Positive Breast Cancer:

(show all 12)
idTitleAuthorsYear
1
Randomized phase II study of lonaprisan as second-line therapy for progesterone receptor-positive breast cancer. (23788750)
2013
2
Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer. (23579222)
2013
3
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. (23971947)
2013
4
A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study. (22548922)
2012
5
Progesterone and levonorgestrel regulate expression of 17I^HSD-enzymes in progesterone receptor positive breast cancer cell line T47D. (22564730)
2012
6
Pilot trial of preoperative (neoadjuvant) letrozole in combination with bevacizumab in postmenopausal women with newly diagnosed estrogen receptor- or progesterone receptor-positive breast cancer. (20705559)
2010
7
Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer? (19703124)
2009
8
Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy. (18302747)
2008
9
Is there a role for adjuvant tamoxifen in progesterone receptor-positive breast cancer? An in silico clinical trial. (16467123)
2006
10
Estrogen receptor alpha-negative and progesterone receptor-positive breast cancer: lab error or real entity? (17189985)
2006
11
Natural history of estrogen receptor-negative, progesterone receptor-positive breast cancer. (12408471)
2002
12
Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group. (9196144)
1997

Variations for Progesterone-Receptor Positive Breast Cancer

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Expression for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Progesterone-Receptor Positive Breast Cancer

Search GEO for disease gene expression data for Progesterone-Receptor Positive Breast Cancer.

Pathways for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters
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Pathways related to Progesterone-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling Pathways in Glioblastoma38
9.3VEGFA, ERBB2
29.3VEGFA, ERBB2
3
Show member pathways
9.3ERBB2, VEGFA
4
Show member pathways
Nuclear Receptors38
9.1PGR, ESR1
5
Show member pathways
9.1PGR, ESR1
6
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1PGR, ESR1
79.1ESR1, VEGFA
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.1VEGFA, ESR1
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.1VEGFA, ESR1
10
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0ESR1, ERBB2
11
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.0ERBB2, ESR1
12
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.0ERBB2, ESR1
13
Show member pathways
8.5ERBB2, ESR1, PGR
148.5VEGFA, ESR1, ERBB2
158.5VEGFA, ESR1, ERBB2
16
Show member pathways
8.0ESR1, PGR, VEGFA, ERBB2

Compounds for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Progesterone-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1ici 164384459.5ESR1, PGR
2idoxifene459.5ESR1, PGR
3triphenylethylene459.5ESR1, PGR
4norgestimate45 1110.4PGR, ESR1
5medroxyprogesterone45 51 29 24 1113.4ESR1, PGR
6trilostane45 1110.4PGR, ESR1
7nandrolone45 2410.4ESR1, PGR
8droloxifene459.4ESR1, PGR
9estradiol benzoate459.4PGR, ESR1
10fadrozole459.3ERBB2, ESR1
11onapristone45 2910.3PGR, ESR1
12desogestrel45 1110.2PGR, ESR1
13capecitabine45 51 1111.2VEGFA, PGR, ERBB2
14goserelin45 29 1111.2PGR, ESR1
15leucovorin45 51 1111.2PGR, VEGFA, ERBB2
16nomegestrol acetate459.1PGR, ESR1
17bisphenol a459.1ESR1, PGR
18leuprolide acetate459.0PGR, ESR1
19mifepristone45 29 61 1111.9VEGFA, PGR, ESR1
20megestrol acetate458.9ESR1, ERBB2, PGR
21anastrozole45 51 1110.9PGR, ESR1, ERBB2
22exemestane45 51 61 1111.9ERBB2, ESR1, PGR
23everolimus45 51 1110.9ERBB2, VEGFA, ESR1
24lapatinib45 51 1110.9ERBB2, ESR1, PGR
25toremifene45 119.9ERBB2, ESR1, PGR
26fulvestrant45 51 29 1111.9ERBB2, ESR1, PGR
27letrozole45 51 61 1111.9PGR, ESR1, ERBB2
28radicicol45 61 1110.9VEGFA, ERBB2, ESR1
29raloxifene45 51 29 1111.9PGR, ESR1, ERBB2
304-hydroxytamoxifen458.9PGR, ESR1, ERBB2
31gefitinib45 51 1110.9VEGFA, ESR1, ERBB2
323,3-diindolylmethane458.8VEGFA, ESR1
33gnrh458.7ESR1, ERBB2, PGR
34methotrexate51 45 1110.7ERBB2, PGR, ESR1
35taxane458.4ERBB2, VEGFA, PGR, ESR1
36trastuzumab45 51 1110.4VEGFA, ESR1, PGR, ERBB2
37progestin458.4PGR, ESR1, ERBB2, VEGFA
38geldanamycin45 51 61 1111.4ERBB2, ESR1, VEGFA, PGR
39resveratrol45 61 24 1111.4ESR1, PGR, VEGFA, ERBB2
40docetaxel45 51 61 1111.4ERBB2, ESR1, PGR, VEGFA
41cyclophosphamide45 51 1110.4VEGFA, ESR1, PGR, ERBB2
425fluorouracil458.4VEGFA, PGR, ESR1, ERBB2
43tamoxifen45 51 29 1111.4ERBB2, ESR1, PGR, VEGFA
44paclitaxel45 51 1110.4ERBB2, ESR1, PGR, VEGFA
45doxorubicin45 51 1110.4ERBB2, ESR1, PGR, VEGFA
46paraffin458.4ESR1, PGR, VEGFA, ERBB2
47genistein45 29 61 3 24 1113.4VEGFA, ESR1, PGR, ERBB2
48cycloheximide458.3ERBB2, ESR1, PGR, VEGFA
49vegf458.3ERBB2, ESR1, PGR, VEGFA
50estrogen458.3ERBB2, VEGFA, PGR, ESR1

GO Terms for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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16Gene Ontology
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Biological processes related to Progesterone-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell adhesionGO:0457859.5ERBB2, VEGFA
2positive regulation of MAP kinase activityGO:0434069.4ERBB2, VEGFA
3positive regulation of epithelial cell proliferationGO:0506799.4ERBB2, VEGFA
4mammary gland alveolus developmentGO:0607499.3ESR1, VEGFA
5positive regulation of protein phosphorylationGO:0019349.2ERBB2, VEGFA
6negative regulation of gene expressionGO:0106299.1PGR, ESR1
7transcription initiation from RNA polymerase II promoterGO:0063679.1ESR1, PGR
8signal transductionGO:0071658.2ERBB2, ESR1, PGR

Molecular functions related to Progesterone-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.1ESR1, PGR
2steroid bindingGO:0054969.0ESR1, PGR
3identical protein bindingGO:0428028.2ERBB2, ESR1, VEGFA

Products for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Progesterone-Receptor Positive Breast Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet