MCID: PRG002
MIFTS: 31

Progesterone-Receptor Positive Breast Cancer malady

Cancer diseases category

Aliases & Classifications for Progesterone-Receptor Positive Breast Cancer

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Aliases & Descriptions for Progesterone-Receptor Positive Breast Cancer:

Name: Progesterone-Receptor Positive Breast Cancer 8


Classifications:



External Ids:

Disease Ontology8 DOID:0060077

Summaries for Progesterone-Receptor Positive Breast Cancer

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MalaCards based summary: Progesterone-Receptor Positive Breast Cancer is related to breast cancer and cerebral meningioma. An important gene associated with Progesterone-Receptor Positive Breast Cancer is PGR (progesterone receptor), and among its related pathways are Chronic myeloid leukemia and HIF-1 signaling pathway. The compounds ici 164384 and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include breast and endothelial, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Related Diseases for Progesterone-Receptor Positive Breast Cancer

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Diseases in the Progesterone-Receptor Positive Breast Cancer family:

Progesterone-Receptor Negative Breast Cancer

Diseases related to Progesterone-Receptor Positive Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.6VEGFA, PGR, ESR1, ERBB2
2cerebral meningioma10.4PGR
3endotheliitis10.4
4malignant mixed mullerian tumor10.1ERBB2, PGR
5cribriform carcinoma10.0PGR, ESR1
6progesterone resistance10.0PGR, ESR1
7meningioma, familial10.0PGR, ESR1
8bilateral breast cancer10.0ESR1, PGR
9adenosarcoma10.0ESR1, PGR
10leiomyomatosis10.0PGR, ESR1
11myoma10.0PGR, ESR1
12endometrial stromal sarcoma10.0PGR, ESR1
13lymphangioleiomyomatosis10.0ESR1, PGR
14angiomyolipoma10.0PGR, ESR1
15cervical adenocarcinoma10.0PGR, ESR1
16gynecomastia10.0ESR1, PGR
17lung cancer10.0ERBB2, VEGFA
18lung cancer susceptibility 310.0ERBB2, VEGFA
19smooth muscle tumor10.0PGR, ESR1
20uterine fibroid9.9ESR1, PGR
21leiomyoma9.9ESR1, PGR
22squamous cell carcinoma, head and neck9.9VEGFA, ERBB2
23endometriosis9.8VEGFA, ESR1, PGR
24mammary paget's disease9.8ERBB2, ESR1, PGR
25breast disease9.8PGR, ERBB2, ESR1
26inflammatory breast carcinoma9.8ESR1, ERBB2, PGR
27ductal carcinoma in situ9.8ESR1, ERBB2, PGR
28tubular adenocarcinoma9.8ERBB2, ESR1, PGR
29breast ductal carcinoma9.8ESR1, PGR, ERBB2
30breast fibroadenoma9.8PGR, ERBB2, ESR1
31li-fraumeni syndrome9.8ESR1, ERBB2, PGR
32factor vii deficiency9.8VEGFA, ESR1, ERBB2
33papillary carcinoma9.8ESR1, PGR, ERBB2
34endometrial cancer9.8PGR, ESR1, ERBB2
35vascular disease9.7ESR1, VEGFA
36prostate cancer9.6ERBB2, ESR1, VEGFA
37ovarian cancer, somatic9.5PGR, VEGFA, ERBB2, ESR1
38adenocarcinoma9.5ESR1, ERBB2, VEGFA, PGR

Graphical network of the top 20 diseases related to Progesterone-Receptor Positive Breast Cancer:



Diseases related to progesterone-receptor positive breast cancer

Symptoms for Progesterone-Receptor Positive Breast Cancer

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Drugs & Therapeutics for Progesterone-Receptor Positive Breast Cancer

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Drug clinical trials:

Search ClinicalTrials for Progesterone-Receptor Positive Breast Cancer

Search NIH Clinical Center for Progesterone-Receptor Positive Breast Cancer

Genetic Tests for Progesterone-Receptor Positive Breast Cancer

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Anatomical Context for Progesterone-Receptor Positive Breast Cancer

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MalaCards organs/tissues related to Progesterone-Receptor Positive Breast Cancer:

31
Breast, Endothelial

Animal Models for Progesterone-Receptor Positive Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Progesterone-Receptor Positive Breast Cancer:

35 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6ESR1, VEGFA, PGR
2MP:00053888.4VEGFA, ESR1, ERBB2
3MP:00053718.3ERBB2, ESR1, PGR, VEGFA
4MP:00020068.3ERBB2, ESR1, PGR, VEGFA
5MP:00053698.3ERBB2, ESR1, VEGFA, PGR
6MP:00053798.3ERBB2, ESR1, VEGFA, PGR
7MP:00053908.2VEGFA, PGR, ESR1, ERBB2
8MP:00107718.2ERBB2, PGR, VEGFA, ESR1
9MP:00053818.2ESR1, VEGFA, ERBB2
10MP:00053808.2ESR1, PGR, VEGFA, ERBB2
11MP:00053898.2ERBB2, VEGFA, ESR1, PGR
12MP:00053858.2VEGFA, ERBB2, ESR1, PGR
13MP:00053868.1ESR1, ERBB2, VEGFA, PGR
14MP:00053848.1ESR1, PGR, VEGFA, ERBB2
15MP:00053768.1ESR1, ERBB2, VEGFA, PGR
16MP:00107688.0ERBB2, ESR1, PGR, VEGFA

Publications for Progesterone-Receptor Positive Breast Cancer

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Articles related to Progesterone-Receptor Positive Breast Cancer:

(show all 14)
idTitleAuthorsYear
1
Clinical significance of SPRR1A expression in progesterone receptor-positive breast cancer. (25424702)
2015
2
Randomized phase II study of lonaprisan as second-line therapy for progesterone receptor-positive breast cancer. (23788750)
2013
3
Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer. (23579222)
2013
4
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. (23971947)
2013
5
A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study. (22548922)
2012
6
Progesterone and levonorgestrel regulate expression of 17I^HSD-enzymes in progesterone receptor positive breast cancer cell line T47D. (22564730)
2012
7
Pilot trial of preoperative (neoadjuvant) letrozole in combination with bevacizumab in postmenopausal women with newly diagnosed estrogen receptor- or progesterone receptor-positive breast cancer. (20705559)
2010
8
Shorter survival-times following adjuvant endocrine therapy in oestrogen- and progesterone-receptor positive breast cancer overexpressing HER2 and/or with an increased expression of vascular endothelial growth factor. (19130322)
2009
9
Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer? (19703124)
2009
10
Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy. (18302747)
2008
11
Is there a role for adjuvant tamoxifen in progesterone receptor-positive breast cancer? An in silico clinical trial. (16467123)
2006
12
Estrogen receptor alpha-negative and progesterone receptor-positive breast cancer: lab error or real entity? (17189985)
2006
13
Natural history of estrogen receptor-negative, progesterone receptor-positive breast cancer. (12408471)
2002
14
Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group. (9196144)
1997

Variations for Progesterone-Receptor Positive Breast Cancer

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Expression for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Search GEO for disease gene expression data for Progesterone-Receptor Positive Breast Cancer.

Pathways for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Pathways related to Progesterone-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3VEGFA, ERBB2
29.3ERBB2, VEGFA
3
Show member pathways
Signaling Pathways in Glioblastoma36
9.3ERBB2, VEGFA
4
Show member pathways
Nuclear Receptors36
9.1PGR, ESR1
5
Show member pathways
9.1ESR1, PGR
6
Show member pathways
Cell cycle ESR1 regulation of G1 S transition59
Immune response MIF JAB1 signaling59
Cell cycle Cell cycle generic schema 59
9.1ESR1, PGR
79.1ESR1, VEGFA
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades59
9.1ESR1, VEGFA
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway59
9.1ESR1, VEGFA
10
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.0ERBB2, ESR1
11
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
9.0ERBB2, ESR1
12
Show member pathways
Development Ligand independent activation of ESR1 and ESR259
9.0ESR1, ERBB2
13
Show member pathways
8.5ERBB2, ESR1, PGR
148.5ERBB2, ESR1, VEGFA
158.5VEGFA, ESR1, ERBB2
16
Show member pathways
8.0VEGFA, PGR, ESR1, ERBB2

Compounds for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Compounds related to Progesterone-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1ici 164384449.5ESR1, PGR
2idoxifene449.5ESR1, PGR
3triphenylethylene449.5ESR1, PGR
4norgestimate44 1110.4PGR, ESR1
5medroxyprogesterone44 50 28 24 1113.4ESR1, PGR
6trilostane44 1110.4PGR, ESR1
7nandrolone44 2410.4ESR1, PGR
8droloxifene449.4ESR1, PGR
9estradiol benzoate449.4PGR, ESR1
10fadrozole449.3ERBB2, ESR1
11onapristone44 2810.3PGR, ESR1
12desogestrel44 1110.2PGR, ESR1
13capecitabine44 50 1111.2VEGFA, PGR, ERBB2
14goserelin44 28 1111.2PGR, ESR1
15leucovorin44 50 1111.2PGR, VEGFA, ERBB2
16nomegestrol acetate449.1PGR, ESR1
17bisphenol a449.1ESR1, PGR
18leuprolide acetate449.0PGR, ESR1
19mifepristone44 28 60 1111.9VEGFA, PGR, ESR1
20megestrol acetate448.9ESR1, ERBB2, PGR
21anastrozole44 50 1110.9PGR, ESR1, ERBB2
22exemestane44 50 60 1111.9ERBB2, ESR1, PGR
23everolimus44 50 1110.9ERBB2, VEGFA, ESR1
24lapatinib44 50 1110.9ERBB2, ESR1, PGR
25toremifene44 119.9ERBB2, ESR1, PGR
26fulvestrant44 50 28 1111.9ERBB2, ESR1, PGR
27letrozole44 50 60 1111.9PGR, ESR1, ERBB2
28radicicol44 60 1110.9VEGFA, ERBB2, ESR1
29raloxifene44 50 28 1111.9PGR, ESR1, ERBB2
304-hydroxytamoxifen448.9PGR, ESR1, ERBB2
31gefitinib44 50 1110.9VEGFA, ESR1, ERBB2
323,3-diindolylmethane448.8VEGFA, ESR1
33gnrh448.7ESR1, ERBB2, PGR
34methotrexate50 44 1110.7ERBB2, PGR, ESR1
35taxane448.4ERBB2, VEGFA, PGR, ESR1
36trastuzumab44 50 1110.4VEGFA, ESR1, PGR, ERBB2
37progestin448.4PGR, ESR1, ERBB2, VEGFA
38geldanamycin44 50 60 1111.4ERBB2, ESR1, VEGFA, PGR
39resveratrol44 60 24 1111.4ESR1, PGR, VEGFA, ERBB2
40docetaxel44 50 60 1111.4ERBB2, ESR1, PGR, VEGFA
41cyclophosphamide44 50 1110.4VEGFA, ESR1, PGR, ERBB2
425fluorouracil448.4VEGFA, PGR, ESR1, ERBB2
43tamoxifen44 50 28 1111.4ERBB2, ESR1, PGR, VEGFA
44paclitaxel44 50 1110.4ERBB2, ESR1, PGR, VEGFA
45doxorubicin44 50 1110.4ERBB2, ESR1, PGR, VEGFA
46paraffin448.4ESR1, PGR, VEGFA, ERBB2
47genistein44 28 60 1 24 1113.4VEGFA, ESR1, PGR, ERBB2
48cycloheximide448.3ERBB2, ESR1, PGR, VEGFA
49vegf448.3ERBB2, ESR1, PGR, VEGFA
50estrogen448.3ERBB2, VEGFA, PGR, ESR1

GO Terms for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Biological processes related to Progesterone-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell adhesionGO:00457859.5ERBB2, VEGFA
2positive regulation of MAP kinase activityGO:00434069.4ERBB2, VEGFA
3positive regulation of epithelial cell proliferationGO:00506799.4ERBB2, VEGFA
4mammary gland alveolus developmentGO:00607499.3ESR1, VEGFA
5positive regulation of protein phosphorylationGO:00019349.2ERBB2, VEGFA
6negative regulation of gene expressionGO:00106299.1PGR, ESR1
7transcription initiation from RNA polymerase II promoterGO:00063679.1ESR1, PGR
8signal transductionGO:00071658.2ERBB2, ESR1, PGR

Molecular functions related to Progesterone-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:00037079.1ESR1, PGR
2steroid bindingGO:00054969.0ESR1, PGR
3identical protein bindingGO:00428028.2ERBB2, ESR1, VEGFA

Sources for Progesterone-Receptor Positive Breast Cancer

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet