MCID: PRG002
MIFTS: 38

Progesterone-Receptor Positive Breast Cancer malady

Cancer diseases category
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Summaries for Progesterone-Receptor Positive Breast Cancer

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MalaCards based summary: Progesterone-Receptor Positive Breast Cancer is related to breast cancer and cerebral meningioma. An important gene associated with Progesterone-Receptor Positive Breast Cancer is PGR (progesterone receptor), and among its related pathways are Chronic myeloid leukemia and HIF-1 signaling pathway. The compounds ici 164384 and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include breast and endothelial, and related mouse phenotypes are no phenotypic analysis and respiratory system.

Aliases & Classifications for Progesterone-Receptor Positive Breast Cancer

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Progesterone-Receptor Positive Breast Cancer, Aliases & Descriptions:

Name: Progesterone-Receptor Positive Breast Cancer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:0060077

Related Diseases for Progesterone-Receptor Positive Breast Cancer

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Diseases in the Progesterone-Receptor Positive Breast Cancer family:

Progesterone-Receptor Negative Breast Cancer

Diseases related to Progesterone-Receptor Positive Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.6ERBB2, ESR1, PGR, VEGFA
2cerebral meningioma10.4PGR
3endotheliitis10.3
4malignant mixed mullerian tumor10.1ERBB2, PGR
5cribriform carcinoma10.0PGR, ESR1
6progesterone resistance10.0PGR, ESR1
7meningioma10.0ESR1, PGR
8bilateral breast cancer10.0ESR1, PGR
9adenosarcoma10.0ESR1, PGR
10leiomyomatosis10.0ESR1, PGR
11myoma10.0ESR1, PGR
12endometrial stromal sarcoma10.0ESR1, PGR
13lymphangioleiomyomatosis10.0PGR, ESR1
14angiomyolipoma10.0ESR1, PGR
15cervical adenocarcinoma10.0PGR, ESR1
16gynecomastia10.0ESR1, PGR
17non-small cell lung carcinoma10.0VEGFA, ERBB2
18lung adenocarcinoma10.0ERBB2, VEGFA
19smooth muscle tumor10.0PGR, ESR1
20uterine fibroid9.9ESR1, PGR
21leiomyoma9.9ESR1, PGR
22squamous cell carcinoma of the head and neck9.9ERBB2, VEGFA
23endometriosis9.8ESR1, PGR, VEGFA
24mammary paget's disease9.8PGR, ESR1, ERBB2
25male breast cancer9.8PGR, ESR1, ERBB2
26inflammatory breast carcinoma9.8ERBB2, ESR1, PGR
27breast cancer, invasive ductal9.8ERBB2, ESR1, PGR
28ductal carcinoma in situ9.8ERBB2, ESR1, PGR
29tubular adenocarcinoma9.8PGR, ESR1, ERBB2
30breast ductal carcinoma9.8ERBB2, ESR1, PGR
31breast fibroadenoma9.8PGR, ESR1, ERBB2
32li-fraumeni syndrome9.8ERBB2, ESR1, PGR
33factor vii deficiency9.8ERBB2, ESR1, VEGFA
34papillary carcinoma9.8ERBB2, ESR1, PGR
35endometrial carcinoma9.8PGR, ESR1, ERBB2
36vascular disease9.8ESR1, VEGFA
37prostate cancer9.6ERBB2, ESR1, VEGFA
38ovarian cancer9.6ERBB2, ESR1, PGR, VEGFA
39adenocarcinoma9.5VEGFA, PGR, ESR1, ERBB2

Graphical network of the top 20 diseases related to Progesterone-Receptor Positive Breast Cancer:



Diseases related to progesterone-receptor positive breast cancer

Symptoms for Progesterone-Receptor Positive Breast Cancer

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Drugs & Therapeutics for Progesterone-Receptor Positive Breast Cancer

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Drug clinical trials:

Search ClinicalTrials for Progesterone-Receptor Positive Breast Cancer

Search NIH Clinical Center for Progesterone-Receptor Positive Breast Cancer

Genetic Tests for Progesterone-Receptor Positive Breast Cancer

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Anatomical Context for Progesterone-Receptor Positive Breast Cancer

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MalaCards organs/tissues related to Progesterone-Receptor Positive Breast Cancer:

32
Breast, Endothelial

Animal Models for Progesterone-Receptor Positive Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Progesterone-Receptor Positive Breast Cancer:

36 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6ESR1, PGR, VEGFA
2MP:00053888.4VEGFA, ESR1, ERBB2
3MP:00053718.3ERBB2, ESR1, PGR, VEGFA
4MP:00020068.3VEGFA, PGR, ESR1, ERBB2
5MP:00053698.3ERBB2, ESR1, PGR, VEGFA
6MP:00053798.3VEGFA, PGR, ESR1, ERBB2
7MP:00053908.2ERBB2, ESR1, PGR, VEGFA
8MP:00107718.2VEGFA, PGR, ESR1, ERBB2
9MP:00053818.2ERBB2, ESR1, VEGFA
10MP:00053808.2ERBB2, ESR1, PGR, VEGFA
11MP:00053898.2VEGFA, PGR, ESR1, ERBB2
12MP:00053858.2ERBB2, ESR1, PGR, VEGFA
13MP:00053868.1VEGFA, PGR, ESR1, ERBB2
14MP:00053848.1ERBB2, ESR1, PGR, VEGFA
15MP:00053768.1VEGFA, PGR, ESR1, ERBB2
16MP:00107688.0ERBB2, ESR1, PGR, VEGFA

Publications for Progesterone-Receptor Positive Breast Cancer

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Articles related to Progesterone-Receptor Positive Breast Cancer:

(show all 13)
idTitleAuthorsYear
1
Randomized phase II study of lonaprisan as second-line therapy for progesterone receptor-positive breast cancer. (23788750)
2013
2
Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer. (23579222)
2013
3
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. (23971947)
2013
4
A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study. (22548922)
2012
5
Progesterone and levonorgestrel regulate expression of 17I^HSD-enzymes in progesterone receptor positive breast cancer cell line T47D. (22564730)
2012
6
Pilot trial of preoperative (neoadjuvant) letrozole in combination with bevacizumab in postmenopausal women with newly diagnosed estrogen receptor- or progesterone receptor-positive breast cancer. (20705559)
2010
7
Shorter survival-times following adjuvant endocrine therapy in oestrogen- and progesterone-receptor positive breast cancer overexpressing HER2 and/or with an increased expression of vascular endothelial growth factor. (19130322)
2009
8
Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer? (19703124)
2009
9
Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy. (18302747)
2008
10
Is there a role for adjuvant tamoxifen in progesterone receptor-positive breast cancer? An in silico clinical trial. (16467123)
2006
11
Estrogen receptor alpha-negative and progesterone receptor-positive breast cancer: lab error or real entity? (17189985)
2006
12
Natural history of estrogen receptor-negative, progesterone receptor-positive breast cancer. (12408471)
2002
13
Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Breast Cancer Site Group. (9196144)
1997

Variations for Progesterone-Receptor Positive Breast Cancer

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Expression for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Expression patterns in normal tissues for genes affiliated with Progesterone-Receptor Positive Breast Cancer

Search GEO for disease gene expression data for Progesterone-Receptor Positive Breast Cancer.

Pathways for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Pathways related to Progesterone-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3VEGFA, ERBB2
29.3ERBB2, VEGFA
3
Show member pathways
Signaling Pathways in Glioblastoma37
9.3ERBB2, VEGFA
4
Show member pathways
Nuclear Receptors37
9.1PGR, ESR1
5
Show member pathways
9.1ESR1, PGR
6
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1ESR1, PGR
79.1ESR1, VEGFA
8
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.1ESR1, VEGFA
9
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.1ESR1, VEGFA
10
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0ERBB2, ESR1
11
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.0ERBB2, ESR1
12
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.0ESR1, ERBB2
13
Show member pathways
8.5ERBB2, ESR1, PGR
148.5ERBB2, ESR1, VEGFA
158.5VEGFA, ESR1, ERBB2
16
Show member pathways
8.0VEGFA, PGR, ESR1, ERBB2

Compounds for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Compounds related to Progesterone-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1ici 164384449.5ESR1, PGR
2idoxifene449.5ESR1, PGR
3triphenylethylene449.5ESR1, PGR
4norgestimate44 1110.4PGR, ESR1
5medroxyprogesterone44 50 28 24 1113.4ESR1, PGR
6trilostane44 1110.4PGR, ESR1
7nandrolone44 2410.4ESR1, PGR
8droloxifene449.4ESR1, PGR
9estradiol benzoate449.4PGR, ESR1
10fadrozole449.3ERBB2, ESR1
11onapristone44 2810.3PGR, ESR1
12desogestrel44 1110.2PGR, ESR1
13capecitabine44 50 1111.2VEGFA, PGR, ERBB2
14goserelin44 28 1111.2PGR, ESR1
15leucovorin44 50 1111.2PGR, VEGFA, ERBB2
16nomegestrol acetate449.1PGR, ESR1
17bisphenol a449.1ESR1, PGR
18leuprolide acetate449.0PGR, ESR1
19mifepristone44 28 61 1111.9VEGFA, PGR, ESR1
20megestrol acetate448.9ESR1, ERBB2, PGR
21anastrozole44 50 1110.9PGR, ESR1, ERBB2
22exemestane44 50 61 1111.9ERBB2, ESR1, PGR
23everolimus44 50 1110.9ERBB2, VEGFA, ESR1
24lapatinib44 50 1110.9ERBB2, ESR1, PGR
25toremifene44 119.9ERBB2, ESR1, PGR
26fulvestrant44 50 28 1111.9ERBB2, ESR1, PGR
27letrozole44 50 61 1111.9PGR, ESR1, ERBB2
28radicicol44 61 1110.9VEGFA, ERBB2, ESR1
29raloxifene44 50 28 1111.9PGR, ESR1, ERBB2
304-hydroxytamoxifen448.9PGR, ESR1, ERBB2
31gefitinib44 50 1110.9VEGFA, ESR1, ERBB2
323,3-diindolylmethane448.8VEGFA, ESR1
33gnrh448.7ESR1, ERBB2, PGR
34methotrexate50 44 1110.7ERBB2, PGR, ESR1
35taxane448.4ERBB2, VEGFA, PGR, ESR1
36trastuzumab44 50 1110.4VEGFA, ESR1, PGR, ERBB2
37progestin448.4PGR, ESR1, ERBB2, VEGFA
38geldanamycin44 50 61 1111.4ERBB2, ESR1, VEGFA, PGR
39resveratrol44 61 24 1111.4ESR1, PGR, VEGFA, ERBB2
40docetaxel44 50 61 1111.4ERBB2, ESR1, PGR, VEGFA
41cyclophosphamide44 50 1110.4VEGFA, ESR1, PGR, ERBB2
425fluorouracil448.4VEGFA, PGR, ESR1, ERBB2
43tamoxifen44 50 28 1111.4ERBB2, ESR1, PGR, VEGFA
44paclitaxel44 50 1110.4ERBB2, ESR1, PGR, VEGFA
45doxorubicin44 50 1110.4ERBB2, ESR1, PGR, VEGFA
46paraffin448.4ESR1, PGR, VEGFA, ERBB2
47genistein44 28 61 2 24 1113.4VEGFA, ESR1, PGR, ERBB2
48cycloheximide448.3ERBB2, ESR1, PGR, VEGFA
49vegf448.3ERBB2, ESR1, PGR, VEGFA
50estrogen448.3ERBB2, VEGFA, PGR, ESR1

GO Terms for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Biological processes related to Progesterone-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell adhesionGO:0457859.5ERBB2, VEGFA
2positive regulation of MAP kinase activityGO:0434069.4ERBB2, VEGFA
3positive regulation of epithelial cell proliferationGO:0506799.4ERBB2, VEGFA
4mammary gland alveolus developmentGO:0607499.3ESR1, VEGFA
5positive regulation of protein phosphorylationGO:0019349.2ERBB2, VEGFA
6negative regulation of gene expressionGO:0106299.1PGR, ESR1
7transcription initiation from RNA polymerase II promoterGO:0063679.1ESR1, PGR
8signal transductionGO:0071658.2ERBB2, ESR1, PGR

Molecular functions related to Progesterone-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.1ESR1, PGR
2steroid bindingGO:0054969.0ESR1, PGR
3identical protein bindingGO:0428028.2ERBB2, ESR1, VEGFA

Products for genes affiliated with Progesterone-Receptor Positive Breast Cancer

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Sources for Progesterone-Receptor Positive Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet