MCID: PRG014
MIFTS: 37

Progesterone Resistance malady

Summaries for Progesterone Resistance

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OMIM:45 Progesterone prepares the endometrium for blastocyst implantation and allows maintenance of pregnancy. The major... (264080) more...

MalaCards based summary: Progesterone Resistance is related to endometriosis and breast cancer, and has symptoms including autosomal recessive inheritance, abnormality of metabolism/homeostasis and female infertility. An important gene associated with Progesterone Resistance is PGR (progesterone receptor), and among its related pathways are Ovarian Infertility Genes and Nuclear signaling by ERBB4. The compounds 2,4,6-trichloro-4-biphenylol and ly 117018 have been mentioned in the context of this disorder. Affiliated tissues include uterus, placenta and breast, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Classifications for Progesterone Resistance

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Sources:
45OMIM, 10diseasecard, 43Novoseek, 60UMLS
See all sources

Progesterone Resistance, Aliases & Descriptions:

Name: Progesterone Resistance 45 10 43 60


External Ids:

OMIM45 264080

Related Diseases for Progesterone Resistance

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Graphical network of the top 20 diseases related to Progesterone Resistance:



Diseases related to progesterone resistance

Symptoms for Progesterone Resistance

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Symptoms by clinical synopsis from OMIM:

264080

Clinical features from OMIM:

264080

HPO human phenotypes related to Progesterone Resistance:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 abnormality of metabolism/homeostasis HP:0001939
3 female infertility HP:0008222

Drugs & Therapeutics for Progesterone Resistance

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Drug clinical trials:

Search ClinicalTrials for Progesterone Resistance

Search NIH Clinical Center for Progesterone Resistance

Genetic Tests for Progesterone Resistance

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Anatomical Context for Progesterone Resistance

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MalaCards organs/tissues related to Progesterone Resistance:

31
Uterus, Placenta, Breast

Animal Models for Progesterone Resistance or affiliated genes

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MGI Mouse Phenotypes related to Progesterone Resistance:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.9PGR, ESR2, ESR1
2MP:00020068.9ESR1, ESR2, PGR
3MP:00053698.8ESR1, ESR2, PGR
4MP:00030128.7ESR1, ESR2, PGR
5MP:00053678.5HSD17B2, ESR2, ESR1
6MP:00053868.1ESR1, ESR2, PGR, HSD17B2
7MP:00107687.7HSD17B2, PGR, ESR2, ESR1

Publications for Progesterone Resistance

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Articles related to Progesterone Resistance:

(show all 20)
idTitleAuthorsYear
1
Endometrial progesterone resistance and PCOS. (24405633)
2014
2
Progesterone receptor isoforms A and B: new insights into the mechanism of progesterone resistance for the treatment of endometrial carcinoma. (24386010)
2013
3
Mechanisms of endometrial progesterone resistance. (22085558)
2012
4
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. (21411543)
2011
5
17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis. (20108182)
2010
6
Altered gene expression profiling in endometrium: evidence for progesterone resistance. (20104428)
2010
7
Revisiting reproduction: Prematurity and the puzzle of progesterone resistance. (20448578)
2010
8
Progesterone resistance in a baboon model of endometriosis. (20104431)
2010
9
Dioxin and endometrial progesterone resistance. (20104429)
2010
10
Subfertility linked to combined luteal insufficiency and uterine progesterone resistance. (20660062)
2010
11
Progesterone resistance and endometrial disease. Preface. (20104423)
2010
12
Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis. (20104427)
2010
13
Endometriosis is associated with progesterone resistance in the baboon (Papio anubis) oviduct: evidence based on the localization of oviductal glycoprotein 1 (OVGP1). (18923157)
2009
14
FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific. (17571166)
2007
15
Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. (17510236)
2007
16
The altered distribution of the steroid hormone receptors and the chaperone immunophilin FKBP52 in a baboon model of endometriosis is associated with progesterone resistance during the window of uterine receptivity. (17636225)
2007
17
Progesterone resistance in endometriosis: link to failure to metabolize estradiol. (16406281)
2006
18
Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. (15117941)
2004
19
Progesterone resistance in women who have had breast cancer. (9532998)
1998
20
Progesterone resistance. (3087144)
1986

Variations for Progesterone Resistance

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Expression for genes affiliated with Progesterone Resistance

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Search GEO for disease gene expression data for Progesterone Resistance.

Pathways for genes affiliated with Progesterone Resistance

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Pathways related to Progesterone Resistance according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4ESR2, PGR
2
Show member pathways
9.3ESR1, PGR
3
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.3ESR1, PGR
49.3ESR2, ESR1
59.3ESR2, ESR1
69.3ESR2, ESR1
7
Show member pathways
9.3ESR1, ESR2
8
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
9.3ESR1, ESR2
9
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.3ESR1, ESR2
109.3ESR1, ESR2
11
Show member pathways
9.3ESR1, ESR2
12
Show member pathways
9.3ESR1, ESR2
13
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.3ESR1, ESR2
149.3ESR1, ESR2
15
Show member pathways
8.8PGR, ESR2, ESR1
16
Show member pathways
Nuclear Receptors36
8.8ESR1, ESR2, PGR

Compounds for genes affiliated with Progesterone Resistance

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Compounds related to Progesterone Resistance according to GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
12,4,6-trichloro-4-biphenylol439.7ESR1, ESR2
2ly 117018439.7ESR2, ESR1
3ici 164384439.7ESR1, PGR
417alpha estradiol439.7ESR2, ESR1
5lasofoxifene439.7ESR2, ESR1
6methylparaben439.7ESR2, ESR1
7r,r-thc289.7ESR2, ESR1
8butylparaben439.7ESR1, ESR2
94-octylphenol439.7ESR2, ESR1
10isopropylparaben439.7ESR2, ESR1
11isobutylparaben439.7ESR2, ESR1
124-hydroxy?aetamoxifen289.7ESR2, ESR1
13idoxifene439.6PGR, ESR1
14zeranol439.6ESR1, ESR2
154-tert-octylphenol439.6ESR1, ESR2
16ici 182,780599.6ESR1, ESR2
17ppt59 2810.5ESR1, ESR2
18dpn599.5ESR1, ESR2
19phtpp59 2810.5ESR1, ESR2
2017beta-estradiol289.4ESR2, ESR1
21triphenylethylene439.4ESR1, PGR
22(z)-4-hydroxytamoxifen599.3ESR2, ESR1
23equol439.3ESR1, ESR2
24trilostane43 1210.3PGR, ESR2, ESR1
25estradiol benzoate439.3ESR1, PGR, ESR2
26nandrolone43 2410.3ESR1, ESR2, PGR
27leuprolide acetate439.3ESR1, PGR, ESR2
28exemestane43 49 59 1212.2ESR1, ESR2, PGR
29anastrozole43 49 1211.2ESR2, ESR1, PGR
30bisphenol a439.2ESR1, ESR2, PGR
31toremifene43 1210.2ESR1, ESR2, PGR
32clomiphene citrate439.2PGR, ESR2, ESR1
33fulvestrant43 49 28 1212.2PGR, ESR2, ESR1
34coumestrol 2 4310.2ESR1, ESR2
35letrozole43 49 59 1212.2PGR, ESR2, ESR1
36levonorgestrel43 59 28 1212.2ESR2, ESR1, PGR
37steroidal439.2ESR1, PGR, ESR2
38diethylstilbestrol43 28 1211.2ESR1, ESR2, PGR
39progestins439.2PGR, ESR1, ESR2
40raloxifene43 49 28 1212.2ESR1, ESR2, PGR
414-hydroxytamoxifen439.1PGR, ESR2, ESR1
42progestin439.1ESR2, ESR1, PGR
43mifepristone43 28 59 1212.0PGR, ESR2, ESR1
44estriol28 24 1210.9ESR1, ESR2, HSD17B2
4517beta-hydroxysteroid438.4ESR1, ESR2, HSD17B2, PGR
46estrone43 28 24 1211.4ESR2, HSD17B2, PGR, ESR1
47estradiol43 24 1210.4PGR, ESR1, ESR2, HSD17B2
48progesterone43 28 59 24 1212.3ESR2, PGR, HSD17B2, ESR1
49testosterone43 59 24 1211.2PGR, ESR1, HSD17B2, ESR2
50steroid437.7PGR, ESR1, ESR2, HSD17B2

GO Terms for genes affiliated with Progesterone Resistance

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Cellular components related to Progesterone Resistance according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056548.8ESR1, ESR2, PGR

Biological processes related to Progesterone Resistance according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:00600659.5ESR1, ESR2
2vagina developmentGO:00600689.4ESR2, ESR1
3intracellular estrogen receptor signaling pathwayGO:00305209.4ESR1, ESR2
4negative regulation of gene expressionGO:00106299.2ESR1, PGR
5positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.0ESR1, ESR2
6transcription initiation from RNA polymerase II promoterGO:00063679.0ESR1, ESR2, PGR
7gene expressionGO:00104678.8PGR, ESR2, ESR1
8signal transductionGO:00071658.8ESR1, ESR2, PGR

Molecular functions related to Progesterone Resistance according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:00340569.4ESR1, ESR2
2estrogen receptor activityGO:00302849.4ESR1, ESR2
3core promoter sequence-specific DNA bindingGO:00010469.2ESR1, ESR2
4ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00048799.1ESR2, PGR
5steroid bindingGO:00054969.0ESR1, ESR2, PGR
6steroid hormone receptor activityGO:00037079.0PGR, ESR2, ESR1
7enzyme bindingGO:00198998.8PGR, ESR2, ESR1
8zinc ion bindingGO:00082708.8ESR1, ESR2, PGR

Products for genes affiliated with Progesterone Resistance

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Progesterone Resistance

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet