Progressive Multifocal Leukoencephalopathy (PML) malady

NIH Rare Diseases:⁴³ Progressive multifocal leukoencephalopathy (pml) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. it is caused by the jc virus (jcv). by age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened. the disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as hodgkin’s disease, lymphoma, and sarcoidosis.  pml is most common among individuals with acquired immune deficiency syndrome (aids). last updated: 4/1/2011

MalaCards: Progressive Multifocal Leukoencephalopathy, also known as leukoencephalopathy, progressive multifocal, is related to systemic lupus erythematosus and acquired immunodeficiency syndrome. An important gene associated with Progressive Multifocal Leukoencephalopathy is IGHMBP2 (immunoglobulin mu binding protein 2), and among its related pathways is purine nucleotides degradation II (aerobic). The compounds deoxyinosine and 9-(beta-d-arabinofuranosyl)guanine have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are skeleton and respiratory system.

Disease Ontology:⁸ A viral infectious disease that involves reactivation of jc polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. the symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.

NINDS:⁴⁴ Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection that targets cells that make myelin--the material that insulates nerve cells (neurons).

Wikipedia:⁶⁴ Progressive multifocal leukoencephalopathy (PML), also known as progressive multifocal... more...

External Ids:

Disease Ontology8 DOID:643 MeSH35 D007968 ICD9CM27 046.3 NCIt40 C26815 SNOMED-CT57 22255007

UMLS via Orphanet62 C0023524 MESH via Orphanet36 D007968 SNOMED-CT via Orphanet58 22255007 ICD1025 A81.2 UMLS61 C0023524

Search GEO for disease gene expression data for Progressive Multifocal Leukoencephalopathy.