Progressive Multifocal Leukoencephalopathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRG009 MIFTS: 50	Progressive Multifocal Leukoencephalopathy malady Categories: Rare diseases, Infectious diseases, Neuronal diseases
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Aliases & Classifications for Progressive Multifocal Leukoencephalopathy

Sources:
¹¹Disease Ontology, ¹³DISEASES, ³⁰ICD10, ³¹ICD10 via Orphanet, ³²ICD9CM, ³⁹MeSH, ⁴⁰MESH via Orphanet, ⁴⁵NCIt, ⁴⁸NIH Rare Diseases, ⁴⁹NINDS, ⁵⁰Novoseek, ⁵⁴Orphanet, ⁶²SNOMED-CT, ⁶⁸UMLS, ⁶⁹UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Progressive Multifocal Leukoencephalopathy:

Name: Progressive Multifocal Leukoencephalopathy ¹¹ ⁴⁸ ⁴⁹ ⁵⁴ ¹³

Leukoencephalopathy, Progressive Multifocal ⁴⁸ ³⁹ ⁶⁸

Pml ¹¹ ⁴⁸ ⁵⁴

Leukoencephalopathy Progressive Multifocal ⁵⁰

Progressive Multifocal Leukoencephalitis ⁵⁴

Characteristics:

Orphanet epidemiological data:

⁵⁴

progressive multifocal leukoencephalopathy:
Inheritance: Not applicable; Age of onset: All ages

Classifications:

MalaCards categories:
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³⁰

Certain infectious and parasitic diseases

Viral infections of the central nervous system

Atypical virus infections of central nervous system

Progressive multifocal leukoencephalopathy

Orphanet: ⁵⁴

Rare neurological diseases

Rare infectious diseases

External Ids:

Disease Ontology¹¹ DOID:643

ICD10³⁰ A81.2

ICD9CM³² 046.3

MeSH³⁹ D007968

NCIt⁴⁵ C26815

SNOMED-CT⁶² 22255007

Orphanet⁵⁴ ORPHA217260

ICD10 via Orphanet³¹ A81.2

MESH via Orphanet⁴⁰ D007968

UMLS via Orphanet⁶⁹ C0023524

UMLS⁶⁸ C0023524

Summaries for Progressive Multifocal Leukoencephalopathy

Sources:
¹¹Disease Ontology, ³⁶MalaCards, ⁴⁸NIH Rare Diseases, ⁴⁹NINDS, ⁷¹Wikipedia
See all MalaCards sources

NIH Rare Diseases:⁴⁸ Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened. The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as Hodgkinâs disease, lymphoma, and sarcoidosis. PML is most common among individuals with acquired immune deficiency syndrome (AIDS). Last updated: 4/1/2011

MalaCards based summary: Progressive Multifocal Leukoencephalopathy, also known as leukoencephalopathy, progressive multifocal, is related to systemic lupus erythematosus and leukemia, acute promyelocytic, somatic. An important gene associated with Progressive Multifocal Leukoencephalopathy is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and Cytokines and Inflammatory Response. Affiliated tissues include brain, t cells and kidney, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and liver/biliary system.

Disease Ontology:¹¹ A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.

NINDS:⁴⁹ Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection that targets cells that make myelin--the material that insulates nerve cells (neurons).

Wikipedia:⁷¹ Progressive multifocal leukoencephalopathy (PML) is a rare and usually fatal viral disease characterized... more...

Related Diseases for Progressive Multifocal Leukoencephalopathy

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Progressive Multifocal Leukoencephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)

id	Related Disease	Score	Top Affiliating Genes
1	systemic lupus erythematosus	29.5	CD40LG, IL2, PDCD1, TNF
2	leukemia, acute promyelocytic, somatic	12.3
3	acute promyelocytic leukemia pml/rara type	12.1
4	spastic paraplegia-paget disease of bone syndrome	10.5	ITGA4, TNF
5	linitis plastica	10.5	IL2, TNF
6	maligant granulosa cell tumor of ovary	10.5	IL2, TNF
7	graft-versus-host disease, protection against	10.5	IL2, TNF
8	addison's disease	10.5	IL2, TNF
9	splenic manifestation of prolymphocytic leukemia	10.5	IL2, TNF
10	night blindness	10.4	CD40LG, TNF
11	ileocolitis	10.4	CD40LG, TNF
12	lipodermatosclerosis	10.4	IL2, TNF
13	scleral disease	10.4	CD40LG, TNF
14	non-secretory myeloma	10.4	CD40LG, TNF
15	potter's syndrome	10.4	IL2, TNF
16	suppurative uveitis	10.4	CD40LG, TNF
17	agammaglobulinemia, microcephaly, and severe dermatitis	10.4	CD40LG, IL2
18	strawberry gallbladder	10.4	CD40LG, IL2
19	lymphoma	10.4
20	phlyctenulosis	10.4	CD40LG, TNF
21	japanese encephalitis	10.4	CD40LG, IL2
22	bolivian hemorrhagic fever	10.4	IL2, TNF
23	alkhurma hemorrhagic fever	10.4	CD40LG, TNF
24	fetal erythroblastosis	10.4	CD40LG, TNF
25	epididymis adenomatoid tumor	10.4	CD40LG, TNF
26	loin pain hematuria syndrome	10.3	CD40LG, TNF
27	gonococcal bursitis	10.3	CD40LG, STAT1
28	leukostasis	10.3	CD40LG, TNF
29	gait apraxia	10.3	CD40LG, TNF
30	malignant histiocytosis	10.3	CD40LG, TNF
31	variola major	10.3	CD40LG, MBP
32	foodborne botulism	10.3	CD40LG, TNF
33	sapho syndrome	10.3	CD40LG, MBP
34	crest syndrome	10.3	CD40LG, TNF
35	diabetic angiopathy	10.3	CD40LG, MBP
36	leukemia	10.3
37	inner ear cancer	10.3	CD40LG, TNF
38	isolated congenital breast hypoplasia/aplasia	10.3	MBP, TNF
39	temporal arteritis	10.3	CD40LG, MBP
40	labyrinthine bilateral reactive loss	10.3	CD40LG, TNF
41	fibrous histiocytoma	10.3	CD40LG, TNF
42	lupus erythematosus	10.2
43	pyoderma gangrenosum	10.2	HTR2A, IL2, TNF
44	dentin dysplasia	10.2	CD40LG, TNF
45	sweat gland cancer	10.2	CD40LG, MBP
46	neurilemmoma	10.2	MBP, TNF
47	spinal polio	10.2	CD40LG, IL2
48	allergic hypersensitivity disease	10.2	CD40LG, TNF
49	gingival disease	10.2	MBP, RPS27A
50	brucella abortus brucellosis	10.2	CD40LG, IL2, TNF

Graphical network of the top 20 diseases related to Progressive Multifocal Leukoencephalopathy:

Symptoms & Phenotypes for Progressive Multifocal Leukoencephalopathy

Sources:
²⁶GenomeRNAi, ⁴¹MGI
See all MalaCards sources

GenomeRNAi Phenotypes related to Progressive Multifocal Leukoencephalopathy according to GeneCards Suite gene sharing:

²⁶

id	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	8.4	CD40LG, IL2, PDCD1, STAT1, TNF

MGI Mouse Phenotypes related to Progressive Multifocal Leukoencephalopathy according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system	MP:0005370	8.8	IL2, MECP2, PDCD1, STAT1, TNF
2	hematopoietic system	MP:0005397	8.4	CD40LG, IL2, ITGA4, MBP, PDCD1, STAT1
3	skeleton	MP:0005390	8.4	CD40LG, HTR2A, MECP2, PDCD1, STAT1, TNF
4	endocrine/exocrine gland	MP:0005379	8.1	CD40LG, HTR2A, IL2, MECP2, PDCD1, STAT1
5	cardiovascular system	MP:0005385	7.8	CD40LG, IGHMBP2, IL2, ITGA4, MECP2, PDCD1
6	cellular	MP:0005384	7.6	CD40LG, IL2, ITGA4, MBP, MECP2, PDCD1
7	immune system	MP:0005387	7.6	CD40LG, IL2, ITGA4, MBP, MECP2, PDCD1
8	mortality/aging	MP:0010768	7.2	CD40LG, IGHMBP2, IL2, ITGA4, MBP, MECP2

Drugs & Therapeutics for Progressive Multifocal Leukoencephalopathy

Sources:
¹BitterDB, ⁴ClinicalTrials, ⁷Cochrane Library, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁴⁶NDF-RT, ⁵⁰Novoseek, ⁵⁶PharmGKB, ⁶⁸UMLS
See all MalaCards sources

Drugs for Progressive Multifocal Leukoencephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Natalizumab

approved, investigational

Phase 4

189261-10-7

Synonyms:

189261-10-7

Anti-VLA4

Anti-alpha4 integrin

D06886

Natalizumab

Natalizumab (INN)

Tysabri

Tysabri (TN)

Methylprednisolone

approved, vet_approved

Phase 4

1153

83-43-2

6741

Synonyms:

(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione

.DELTA.1-6.alpha.-Methylhydrocortisone

1-Dehydro-6alpha-methylhydrocortisone

1-dehydro-6alpha-Methylhydrocortisone

1-dehydro-6α-methylhydrocortisone

11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione

11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

121673-01-6

4-08-00-03498 (Beilstein Handbook Reference)

46436_FLUKA

46436_RIEDEL

570-35-4

6 Methylprednisolone

6-Methylprednisolone

6-alpha-Methylprednisolone

6.alpha.-Methylprednisolone

6923-42-8

6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione

6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methylprednisolone

6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

83-43-2

AC1L1N7A

Artisone-Wyeth

Artisone-wyeth

BPBio1_000174

BRD-K35240538-001-03-1

BRN 2340300

BSPBio_000158

Besonia

Bio-0658

CHEBI:6888

CHEMBL650

CID6741

CPD000058330

D00407

D008775

DB00959

Depo-Medrol (acetate)

Dopomedrol

EINECS 201-476-4

Esametone

Firmacort

HMS1568H20

HMS2090B13

HSDB 3127

LMST02030178

LS-118498

Lemod

M0639_SIGMA

M1665

MEPRDL

MLS000028541

MLS001148159

MLS002207191

Medesone

Medixon

Medlone 21

Medrate

Medrol

Medrol (TN)

Medrol Adt Pak

Medrol Dosepak

Medrol adt pak

Medrol dosepak

Medrol, Solu-Medrol, Medrone, Methylprednisolone

Medrone

Mesopren

Metastab

Methyleneprednisolone

Methylprednisolon

Methylprednisolone

Methylprednisolone (JP15/USP/INN)

Methylprednisolone [USAN:INN:BAN:JAN]

Methylprednisolone, 6-alpha

Methylprednisolonum

Methylprednisolonum [INN-Latin]

Metilbetasone

Metilprednisolona

Metilprednisolona [INN-Spanish]

Metilprednisolone

Metilprednisolone [DCIT]

Metilprednisolone [Dcit]

Metipred

Metrisone

Metrocort

Metysolon

Moderin

MolPort-002-528-554

NCGC00022735-03

NCI60_001657

NSC-19987

NSC19987

Nirypan

Noretona

Predni N Tablinen

Prednol- L

Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)

Prestwick0_000279

Prestwick1_000279

Prestwick2_000279

Prestwick3_000279

Prestwick_622

Promacortine

Reactenol

S1733_Selleck

SAM002589984

SMR000058330

SPBio_002377

Sieropresol

Solomet

Summicort

Suprametil

U 7532

UNII-X4W7ZR7023

Urbason

Urbasone

Wyacort

ZINC03875560

delta(1)-6alpha-Methylhydrocortisone

delta(sup 1)-6-alpha-Methylhydrocortisone

methylprednisolone

methylprenisolone

Prednisolone

approved, vet_approved

Phase 4

1153

50-24-8

5755

Synonyms:

(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

.DELTA.1-Cortisol

.DELTA.1-Dehydrocortisol

.DELTA.1-Dehydrohydrocortisone

.DELTA.1-Hydrocortisone

.delta.-Cortef

.delta.-Stab

1,2-Dehydrohydrocortisone

1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione

1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol

1-Dehydrocortisol

1-Dehydrohydrocortisone

3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene

46656_FLUKA

46656_RIEDEL

50-24-8

58201-11-9

8056-11-9

AC-1773

AC1L1L2E

Ak-Pred

Ak-Tate

Alphadrol

Articulose-50

BPBio1_000164

BRD-K98039984-001-03-0

BRN 1354103

BSPBio_000148

Bio-0666

Bubbli-Pred

C07369

CCRIS 980

CHEBI:8378

CHEMBL131

CID5755

CO-Hydeltra

CPD000718761

Co-Hydeltra

Codelcortone

Cordrol

Cortalone

Cotogesic

Cotolone

D00472

D011239

DB00860

Decaprednil

Decortin H

Delcortol

Delta F

Delta(1)-dehydrohydrocortisone

Delta-Cortef

Delta-Cortef (TN)

Delta-Ef-Cortelan

Delta-Stab

Delta-stab

Deltacortenol

Deltacortril

Deltacortril Enteric

Deltahydrocortisone

Deltasolone

Deltisilone

Depo-Medrol

Derpo PD

Derpo Pd

Dexa-Cortidelt Hostacortin H

Dexa-Cortidelt hostacortin H

Di Adreson F

Di-Adreson F

Di-Adreson-F

Di-adreson F

DiAdresonF

Dicortol

Donisolone

Dydeltrone

EINECS 200-021-7

Eazolin D

Econopred

Econopred Plus

Erbacort

Erbasona

Estilsona

Fernisolone

Fernisolone P

Fernisolone-P

Flamasone

HMS1568H10

HMS2090J05

HSDB 3385

Hostacortin H

Hydeltra

Hydeltra-Tba

Hydeltrasol

Hydeltrone

Hydrodeltalone

Hydrodeltisone

Hydroretrocortin

Hydroretrocortine

I-Pred

Inflamase Forte

Inflamase Mild

K 1557

Key-Pred

Klismacort

LMST02030179

LS-7669

Lentosone

Lite Pred

M-Predrol

MLS001304083

MLS002154250

MLS002207037

Medrol

Medrol Acetate

Metacortandralone

Methylprednisolone Acetate

Meti-Derm

Meticortelone

Metreton

MolPort-002-507-147

NCGC00179649-01

NSC 9120

NSC9120

NSC9900

Neo-Delta-Cortef

Nisolone

Nor-Pred T.B.A.

Ocu-Pred

Ocu-Pred Forte

Ophtho-Tate

Orapred

P0152_SIGMA

P0637

P6004_SIGMA

PRDL

PRED-G

Panafcortelone

Paracortol

Paracotol

Pediapred

Poly-Pred

Precortalon

Precortancyl

Precortilon

Precortisyl

Pred Forte

Pred Mild

Predair

Predair A

Predair Forte

Predalone 50

Predalone T.B.A.

Predate

Predate Tba

Predate-50

Predcor-25

Predcor-50

Predcor-Tba

Predisolone Sodium Phosphate

Predne-Dome

Prednelan

Predni-Dome

Prednicen

Predniliderm

Predniretard

Prednis

Prednisolona

Prednisolona [INN-Spanish]

Prednisolone (JP15/USP/INN)

Prednisolone (anhydrous)

Prednisolone Acetate

Prednisolone Sodium Phosphate

Prednisolone Tebutate

Prednisolone [INN:BAN:JAN]

Prednisolonum

Prednisolonum [INN-Latin]

Predonin

Predonine

Prelone

Prenolone

Prestwick0_000274

Prestwick1_000274

Prestwick2_000274

Prestwick3_000274

Prestwick_404

Rolisone

S1737_Selleck

SAM002264639

SMR000718761

SPBio_002367

Scherisolon

Solone

Steran

Sterane

Sterolone

Supercortisol

UNII-9PHQ9Y1OLM

Ulacort

Ultra Pred

Ultracorten H

Ultracortene H

Ultracortene-H

Ultracortene-Hydrogen

Ultracortene-hydrogen

ZINC03833821

component of Ataraxoid

component of K-Predne-Dome

delta(1)-Cortisol

delta(1)-Dehydrocortisol

delta(1)-Dehydrohydrocortisone

delta(1)-Hydrocortisone

delta(sup 1)-Cortisol

delta(sup 1)-Dehydrocortisol

delta(sup 1)-Dehydrohydrocortisone

delta(sup 1)-Hydrocortisone

delta-dehydrocortisol

delta-dehydrohydrocortisone

delta-hydrocortisone

prednisolone

Interferon beta-1b

approved

Phase 4

145155-23-3

Synonyms:

Betaseron

Fibroblast interferon

IFN-beta

Interferon beta precursor

Immunosuppressive Agents

Phase 4, Phase 2

12770

Adjuvants, Immunologic

Phase 4

2484

Anti-Infective Agents

Phase 4, Phase 2, Phase 1

21402

Antiviral Agents

Phase 4, Phase 2

9732

Interferon-beta

Phase 4

280

interferons

Phase 4

2137

Gastrointestinal Agents

Phase 4, Phase 2

8109

Prednisolone hemisuccinate

Phase 4

1153

Prednisolone phosphate

Phase 4

1153

Protective Agents

Phase 4

7190

Antiemetics

Phase 4

3888

Autonomic Agents

Phase 4

9774

Prednisolone acetate

Phase 4

1153

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4

12767

Hormone Antagonists

Phase 4

12778

glucocorticoids

Phase 4

4920

Fingolimod Hydrochloride

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

5407

Hormones

Phase 4

13979

Methylprednisolone acetate

Phase 4

1153

Peripheral Nervous System Agents

Phase 4

22776

Neuroprotective Agents

Phase 4

1672

Anti-Inflammatory Agents

Phase 4

10355

Methylprednisolone Hemisuccinate

Phase 4

1153

Lenograstim

approved

Phase 2

1202

135968-09-1

Synonyms:

G-CSF (CHO cell derived)

Glycosylated recombinant G-CSF

Glycosylated recombinant granulocyte colony stimulating factor

Granulocyte colony stimulating factor 3 (CHO cell derived)

Granulocyte colony-stimulating factor lenograstim

Lenograstim (genetical recombination)

Lenograstim rDNA

Didanosine

approved

Phase 2

150

69655-05-6

50599

Synonyms:

149409-57-4

2',3'-Dideoxyinosine

2',3'-Dideoxyinosine & Granulocyte-macrophage colony-stimulating factor

2',3'-Dideoxyinosine & Interferon-.alpha.

2',3'-Dideoxyinosine & sCD4(soluble recombinant protein)

2',3'-Dideoxyinosine (AIDS Initiative)

2',3'-Dideoxyinosine (ddI)

2',3'-dideoxyinosine, DDI, NSC 612049, Didanosine

2'3'-DIDEOXYINOSINE

2,3-Dideoxyinosine

2,3-dideoxyinosine

2DI

3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine

69655-05-6

9-((2R,5S)-5-(Hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one

9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol

9-(2,3-Dideoxy-beta-D-ribofuranosyl)-6-oxopurine

9-(2,3-Dideoxy-beta-D-ribofuranosyl)hypoxanthine

9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE

9-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

AC-12026

AC1L19ET

AC1L3OPK

BMY 40900

BMY-40900

BRN 3619529

Benzeneethanamine, 4-methoxy-3-(2-phenylethoxy)-N,N-dipropyl-, hydrochloride

Bio-0685

C06953

C083832

CCRIS 805

CHEBI:490877

CHEMBL1460

CID119381

CID50599

CPD000058576

D00296

D2I

D3066

DB00900

DB02392

DDI

DDI and rIFN.alpha.2

DIDEOXYINOSINE

DRG-0016

DS-4152 & ddI

DdIno

Didanosina

Didanosina [INN-Spanish]

Didanosine

Didanosine (JAN/USAN/INN)

Didanosine and Interferon-.alpha.-2

Didanosinum

Didanosinum [INN-Latin]

Dideoxyinosine

Dideoxyinosine (DDI)

FT-0082664

HMS2051J11

HMS2089N20

HSDB 6548

Hypoxanthine ddN

Inosine, 2',3'-dideoxy- & Recombinant Interferon-.alpha.-2

Intron A & Videx

KS-1049

LOA & ddI

Listera ovata agglutinin & 2',3'-Dideoxyinosine

MLS000759469

MLS001055350

MLS001424118

MLS002154216

MolPort-002-507-371

MolPort-002-885-819

N,N-Dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride

N,N-diethyl-2-(4-methoxy-3-phenethyloxyphenyl)ethanamine hydrochloride

NCGC00090691-01

NCGC00159514-02

NCGC00159514-03

NCGC00164280-01

NE 100

NE-100

NSC 612049

NSC-612049

NSC612049

PC-SOD+ddI

S1702_Selleck

SAM001246673

SMR000058576

Sulfated polysaccharide-peptidoglycan DS-4152 & 2',3'-Dideoxyinosine

UNII-K3GDH6OH08

Videx

Videx (TN)

Videx EC

Videx EC(TM)(slow-release capsules)

Videx(TM)

ZINC13597823

ddI & GM-CSF

ddI & IFN-.alpha.

ddI & sCD4(rsCD4)

ddI + d4T combination

ddIno

didanosine

Zalcitabine

approved

Phase 2

7481-89-2

24066

Synonyms:

.beta.-D-2',3'-Dideoxycytidine

.beta.-D-2',3'-Dideoxycytidine & Granulocyte-macrophage colony-stimulating factor

.beta.-D-DDC

1-(2,3-Dideoxy-beta-D-ribofuranosyl)cytosine

16803P

2',3'-DIDEOXYCYTIDINE

2',3'-Dideoxycytidine

2',3'-Dideoxycytidine & Interferon.alpha.

2',3'-Dideoxycytidine & Nanoparticles (from human serum albumin or polyhexylcyanoacrylate)

2',3'-Dideoxycytidine & sCD4(soluble recombinant protein)

2,3-dideoxycytidine

3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine

36775_FLUKA

4-amino-1-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one

4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one

5-25-14-00313 (Beilstein Handbook Reference)

7481-89-2

AC-824

AC1L2N6R

BPBio1_001378

BRN 0654956

BSPBio_001253

C07207

C9H13N3O3

CCRIS 692

CHEBI:10101

CHEMBL853

CID24066

CPD000058253

Cytidine, 2',3'-dideoxy- & Colony-stimulating factor

Cytidine, 2',3'-dideoxy- & Interferon.alpha.

D 5782

D00412

D3581

D5782_SIGMA

DB00943

DDC

DDC (DDC)

DDCYD

DS-4152 & ddC

Dideoxycytidine

EU-0100360

HIVID

HMS1548B19

HMS1571O15

HMS2051H18

HMS2090C12

HSDB 7156

Hivid (TN)

Hivid(TM)

Hivid, Dideoxycytidine, NSC 606170, Zalcitabine

Interferon AD + ddC

KS-1130

LS-1645

Lecithinized superoxide dismutase & .beta.-D-2',3'-Dideoxycytidine

Lopac0_000360

MLS000069636

MLS000759540

MLS001055363

MLS001424210

MolPort-002-885-873

NCGC00090705-01

NCGC00090705-02

NCGC00090705-03

NCGC00090705-05

NCGC00090705-06

NCGC00090705-07

NCGC00090705-10

NCGC00179242-01

NSC 606170

NSC-606170

NSC606170

PC-SOD & ddC

Prestwick0_001037

Prestwick1_001037

Prestwick2_001037

Prestwick3_001037

Ro 24-2027/000

Ro-24-2027/000

S1719_Selleck

SAM001246779

SMR000058253

SPBio_003104

SRI-7707

Sulfated polysaccharide-peptidoglycan DS-4152 & 2',3'-Dideoxycytidine

TimTec1_004969

UNII-6L3XT8CB3I

UPCMLD-DP115

UPCMLD-DP115:001

ZINC00039906

Zalcitabine (JAN/USP/INN)

Zalcitabine [USAN:INN:BAN]

Zalcitibine

bmse000712

ddC

ddC & GM-CSF

ddC & IFN.alpha.

ddC & Interferon.alpha.

ddC & NP (from PHCA or HSA)

ddC & sCD4

ddC (Antiviral)

ddCyd

zalcitabine

Vedolizumab

approved

Phase 2

943609-66-3

Synonyms:

Entyvio

Cytarabine

approved, investigational

Phase 2

1093

147-94-4

6253

Synonyms:

(beta-D-Arabinofuranosyl)cytosine

(beta-D-arabinofuranosyl)cytosine

1-.beta.-D-arabinofuranosyl-cytosine

1-Arabinofuranosylcytosine

1-beta -D-Arabinofaranosylcytosine

1-beta -D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone

1-beta -D-Arabinofuranosylcytosine

1-beta-D-Arabinofaranosylcytosine

1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone

1-beta-D-Arabinofuranosyl-Cytosine

1-beta-D-Arabinofuranosylcytosine

1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside

1-beta-D-Arabinosyl-Cytosine

1-beta-D-Arabinosylcytosine

147-94-4

1beta -Arabinofuranasylcytosine

1beta -D-Arabinofuranosylcytosine

1beta -D-Arabinosylcytosine

1beta-Arabinofuranasylcytosine

1beta-D-Arabinofuranosylcytosine

1beta-D-Arabinosylcytosine

2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl- [CAS]

2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl

30399_FLUKA

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine

4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one

69-74-9 (hydrochloride)

AC-1075

AC1L1M4F

AC1Q52OJ

AI3-52329

AR3

Alexan

Ara-C

Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine

Ara-Cytidine

AraC

Arabinocytidine

Arabinofuranosyl Cytidine

Arabinofuranosylcytosine

Arabinosyl Cytosine

Arabinosylcytosine

Arabitin

Aracytidine

Aracytin

Aracytine

Arafcyt

BIDD:GT0371

BIDD:PXR0139

BTB15125

Beta-cytosine arabinoside

C02961

C1768_SIGMA

C2035

C9H13N3O5

CCRIS 913

CHEBI:28680

CHEMBL803

CHX 3311

CID6253

CPD000449317

CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9)

Citarabina

Citarabina [INN-Spanish]

Cytarabin

Cytarabina

Cytarabine

Cytarabine (JP15/USP/INN)

Cytarabine [USAN:INN:BAN:JAN]

Cytarabine liposome injection

Cytarabinoside

Cytarabinum

Cytarabinum [INN-Latin]

Cytarbel

Cytonal

Cytosar

Cytosar-U

Cytosine 1-beta-D-arabinofuranoside

Cytosine arabinofuranoside

Cytosine arabinose

Cytosine arabinoside

Cytosine arabinoside (VAN)

Cytosine beta-D-arabinofuranoside

Cytosine beta-D-arabinofuranoside hydrochloride

Cytosine beta-D-arabinoside

Cytosine, beta -D-arabinoside

Cytosine, beta-D-arabinoside

Cytosine-1-beta-D-arabinofuranoside

Cytosine-1-beta-D-arabinofuranoside hydrochloride

Cytosine-beta -D-arabinofuranoside

Cytosine-beta -arabinoside

Cytosine-beta-D-arabinofuranoside

Cytosine-beta-arabinoside

Cytosinearabinoside

D00168

DB00987

DepoCyte

Depocyt

Depocyt (TN)

Depocyt (liposomal)

Depocyte

EINECS 205-705-9

Erpalfa

FT-0082880

HMS2051K19

HMS2090A18

HSDB 3049

Intrathecal (injected into the spinal fluid) DepoCyt

Intrathecal cytarabine (also known as ara-C)

Iretin

LS-860

Lopac0_000316

MLS000758310

MLS001066340

MolPort-001-792-509

NCGC00093356-03

NCGC00093356-04

NCGC00093356-05

NCI-C04728

NSC 287459

NSC287459

S1648_Selleck

SAM001247012

SMR000449317

SR-01000075773-3

Spongocytidine

TL8001048

Tarabine

U 19920A

U-19,920

U-19920

UNII-04079A1RDZ

Udicil

ZINC03795098

beta -D-arabinosylcytosine

beta -arabinosylcytosine

beta -cytosine arabinoside

beta-Ara C

beta-Ara c

beta-Arabinosylcytosine

beta-Cytosine arabinoside

beta-D-Arabinosylcytosine

cytarabine

cytarabine liposome injection

cytosine-β-D-arabinofuranoside

Topotecan

approved, investigational

Phase 2

339

119413-54-6, 123948-87-8

60700

Synonyms:

(4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione

(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE

(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione

(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

123948-87-8

9-Dimethylaminomethyl-10-hydroxycamptothecin

9-[(dimethylamino)Methyl]-10-hydroxy-(4S)-camptothecin

AC-11592

AC1L1TQZ

AC1Q6APZ

BSPBio_002348

C11158

C23H23N3O5

CCRIS 8163

CHEBI:107501

CHEBI:46035

CHEMBL84

CID60700

D08618

DB01030

HMS2090B20

HSCI1_000228

Hycamptamine

Hycamptin

Hycamtamine

Hycamtin

Hycamtin (TN)

LS-127395

MLS000759456

NCGC00178695-01

NCI60_004771

NCIStruc1_001659

NCIStruc2_001796

NChemBio.2007.10-comp24

NSC609699

SK&F-104864-A

SKF 104864

SKF-104864-A

SKF-S 104864

SMP2_000312

SMP2_000327

SMR000466344

TOPO

TOPOTECAN, HYCAMTIN

TPT

TTC

Topotecan (BAN)

Topotecan Hcl

Topotecan Hydrochloride

Topotecan Lactone

Topotecan Monohydrochloride, (S)-Isomer

Topotecan [INN:BAN]

Topotecan lactone

Topotecane

Topotecane [INN-French]

Topotecanum

Topotecanum [INN-Latin]

UNII-7M7YKX2N15

topotecan

Zidovudine

approved

Phase 2

494

30516-87-1

35370

Synonyms:

-Azido-3&prime

-deoxythymidine

1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine

3&prime

3' Azido 2',3' Dideoxythymidine

3' Azido 3' deoxythymidine

3'-Azido-2',3'-Dideoxythymidine

3'-Azido-3'-deoxythymidine

3'-Azido-3'-deoxythymidine & Concanavalin A

3'-Azido-3'-deoxythymidine & Erythropoietin

3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19

3'-Azido-3'-deoxythymidine & Interleukin-1

3'-Azido-3'-deoxythymidine & Interleukin-2

3'-Azido-3'-deoxythymidine & Interleukin-6

3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin

3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1

3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6

3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon

3'-Azido-3'-deoxythymidine & Sho-Saiko-To

3'-Azido-3'-deoxythymidine (AIDS)

3'-Azido-3'deoxythymidine & Interferon .alpha.

3'-Azidothymidine

3'-Deoxy-3'-azidothymidine

3'-azido-3'-deoxythymidine, AZT

3-Azido-3-deoxythymidine

30516-87-1

399024-19-2

A2169_SIGMA

AC1L1TKL

AC1Q2OEK

AZT

AZT & CD4(178)-PE 40

AZT & Colony-stimulating factor 2

AZT & Concanavalin A (ConA)

AZT & EPO

AZT & GM-CSF

AZT & HPA

AZT & IFN.alpha.

AZT & IL-1

AZT & IL-2

AZT & IL-6

AZT & Interferon-.alpha.-2

AZT & Li & EPO

AZT & Li & GM-CSF

AZT & Li & IL-1

AZT & Li & IL-6

AZT & Lymphoblastoid Interferon

AZT & NP (from PHCA or HSA)

AZT & PM-19

AZT & SST

AZT & rIFN.alpha.2

AZT & rsCD4 & rIFN.alpha.A

AZT & rsT4

AZT & sCD4

AZT & srCD4

AZT (Antiviral)

AZT Antiviral

AZT TRANSPLACENTAL CARCINOGENESIS STUDY

AZT+PRO 140

AZT, Antiviral

Antiviral AZT

Apo-Zidovudine

Azidothymidine

Aztec

BB_NC-1012

BPBio1_000403

BRD-K72903603-001-04-6

BSPBio_000365

BSPBio_003153

BW A509U

BW-A 509U

BW-A-509U

BW-A509U

BWA 509U

BWA-509U

BWA509U

C07210

CCRIS 105

CHEBI:10110

CHEBI:127307

CHEMBL129

CID35370

CPD000058351

Compound S

Cpd S

D00413

D015215

DB00495

DRG-0004

DS-4152 & AZT

DivK1c_000524

HMS1921J20

HMS2090G11

HMS2092D06

HMS501K06

HSDB 6515

IDI1_000524

Interferon AD + 3'-azido-3'-deoxythymidine

Intron A & AZT

K7 [P Ti2 W10 O40]

KBio1_000524

KBio2_001828

KBio2_004396

KBio2_006964

KBio3_002653

KBioGR_000703

KBioSS_001828

LS-1159

Liposomal AZT-SN-1

Liposomal AZT-SN-3

MLS000028548

MLS001055351

MLS001076358

MLS002153202

MLS002222249

Met-SDF-1.beta. & AZT

Met-SDF-1.beta. & Zidovudine

MolPort-002-507-286

NCGC00023945-03

NCGC00023945-04

NCGC00023945-05

NCGC00023945-08

NCGC00178237-01

NCGC00178237-02

NINDS_000524

NSC 602670

Novo-Azt

PC-SOD+AZT

Prestwick3_000333

Propolis+AZT

Racemic Liposomal AZT

Retrovir

Retrovir (TN)

Retrovir(TM)

SAM002548971

SMR000058351

SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)

SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)

SPBio_000834

SPECTRUM1502109

STK801891

Spectrum2_000927

Spectrum3_001507

Spectrum4_000332

Spectrum5_001101

Spectrum_001348

UNII-4B9XT59T7S

ZDV

ZIDOVUDINE [AZT]

ZINC03779042

ZVD

Zidovudin

Zidovudina

Zidovudina [Spanish]

Zidovudine (JAN/USP/INN)

Zidovudine EP III

Zidovudine [USAN:INN:BAN:JAN]

Zidovudine+PRO 140

Zidovudinum

Zidovudinum [Latin]

antiviral

azidodeoxythymidine

rIFN-beta seron & AZT

racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)

zidovudin

zidovudine

Emtricitabine

approved, investigational

Phase 2

439

143491-57-0

60877

Synonyms:

(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

(-)-.beta.-L-FTC

(-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine

(-)-2'-Deoxy-5-fluoro-3'-thiacytidine

(-)-FTC

(-)-beta-2',3'-Dideoxy-5-fluoro-3'-thiacytidine

(-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine

(-)-cis-4-amino-5-Fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one

(-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one

(2R-cis)-4-Amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone

(2R-cis)-4-amino-5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone

.beta.-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine

143491-54-7

143491-57-0

145213-48-5

2',3',5-FTC

2',3'-Dideoxy-5-fluoro-3'-thiacytidine

2'-Deoxy-5-fluoro-3'-oxa-4'-thiocytidine

2'-Deoxy-5-fluoro-3'-thiacytidine

2-FTC

3'-Thia-2'.3'-dideoxy-5-fluorocytidine

4-Amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one

4-Amino-5-fluoro-1-[(2R,5S)-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

4-amino-5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one

4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one

4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one

5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)[1,3]oxathiolan-5-yl]cytosine

524W91

AC1L1U3I

AC1Q4KUB

BW 1592

BW 524W91

BW-524W91

BW524W91

C122114

C12599

C8H10FN3O3S

CHEBI:31536

CHEMBL885

CID60877

Coviracil

Coviracil(TM)

D01199

DB00879

DRG-0208

Emtricitabin

Emtricitabina

Emtricitabine

Emtricitabine (JAN/USAN/INN)

Emtricitabinum

Emtriva

Emtriva (TN)

Emtriva(TM)

FT-0080009

HMS2089I05

HSDB 7337

LS-135838

LS-173184

NCGC00164564-01

RCV

Racivir

SBB066061

TL8000958

UNII-G70B4ETF4S

ZINC03629271

beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine

dOTFC

emtricitabine

Enfuvirtide

approved, investigational

Phase 2

159519-65-0

16130199

Synonyms:

262434-79-7

C105196

DP178

Dp 178

Enfuvirtide

Enfuvirtide [USAN]

Envelope polyprotein GP160 precursor [Contains: Exterior membrane glycoprotein,GP120, Transmembrane glycoprotein,GP41]

Fuzeon

HSDB 7341

LS-183961

N-Acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histadyl-L-seryl-L-leucyl-L-isoleucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-alpha-glutamyl-L-lysyl-L-asparaginyl-L-alpha-glutamyl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-leucyl-L-alpha-aspartyl-L-lysyl-L-tryptophyl-L-alanyl-L-seryl-L-leucyl-L-tryptophyl-L-asparaginyl-L-tryptophyl-L-phenylalaninamide

Pentafuside

Roche brand of pentafuside

T 20

T 20 (peptide)

T-20

T-20 cpd

T20 peptide

UNII-19OWO1T3ZE

peptide T20

Tenofovir

approved, investigational

Phase 2

733

147127-20-6

464205

Synonyms:

(R)-9-(2-Phosphonomethoxypropyl)adenine

(R)-9-(2-Phosphonylmethoxypropyl)adenine

(R)-9-(2-phosphonomethoxypropyl)adenine

(R)-PMPA

147127-20-6

206184-49-8

AC-760

AC1LA9BO

Anh. tenofovir

Anhydrous tenofovir

Apropovir

CHEBI:45809

CHEMBL483

CID464205

D,L-Tenofovir

DB00300

GNA & Tenofovir

GS 1275

GS 1278

GS1278

HHA & Tenofovir

KS-5021

MolPort-003-850-411

NCGC00167535-01

PMPA

PMPA-(R)

Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Galanthus nivalis agglutinin (GNA)

Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Hippeastrum hybrid agglutinin( HHA)

Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI)

Phosphonic acid, [[2-(6-amino-9H-purin-9

S1401_Selleck

TDF

TFV

Tenefovir

Tenofovir

Tenofovir (anh.)

Tenofovir disoproxil

Tenofovir disoproxil fumarate

UNII-99YXE507IL

Viread

Viread, Tenofovir

[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid

Mefloquine

approved

Phase 1, Phase 2

53230-10-7

4046

Synonyms:

(+)-(11R,2'S)-erythro-Mefloquine

(+)-Mefloquine

(+)-Threo-Mefloquine

(-)-(11S,2'R)-erythro-Mefloquine

(-)-Mefloquine

(-)-Threo-Mefloquine

(DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

(R)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol

(R)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol

(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol

(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol

(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol

49752-90-1

51688-68-7

51742-87-1

51744-84-4

51744-85-5

53230-10-7

68682-27-9

AB00052310

AC1L1HAJ

AC1L249S

AC1L9UO6

AC1MHD7J

AC1MHD7O

AC1Q4K1I

AR-1G4597

BIDD:GT0596

BIDD:PXR0166

BPBio1_000190

BRD-A89585551-003-03-4

BSPBio_000172

C07633

C17H16F6N2O

CAS-51773-92-3

CHEBI:151162

CHEBI:403542

CHEMBL411329

CHEMBL411685

CHEMBL411686

CHEMBL416956

CID3000506

CID3000516

CID4046

CID40692

CID456309

D04895

DB00358

DivK1c_000790

EINECS 256-468-3

Erthro-.alpha.-[2-piperidyl]-2,8-bis[trifluoromethyl]-4-quinolinemethanol

HMS1922C09

HMS502H12

HSDB 6853

IDI1_000790

KBio1_000790

KBio2_001792

KBio2_004360

KBio2_006928

KBio3_002046

KBioGR_001392

KBioSS_001792

LS-142023

LS-187797

Lariam

Lariam (Hydrochloride)

Mefloquin

Mefloquina

Mefloquina [INN-Spanish]

Mefloquine

Mefloquine (USAN/INN)

Mefloquine HCL

Mefloquine [USAN:INN:BAN]

Mefloquine aziridine

Mefloquinone

Mefloquinum

Mefloquinum [INN-Latin]

Mephloquine

MolPort-003-981-155

Méfloquine

NCGC00016864-01

NCGC00094994-01

NCGC00094994-02

NCGC00094994-03

NCGC00094994-04

NCGC00161831-01

NCGC00161831-02

NINDS_000790

NSC157387

Prestwick0_000126

Prestwick1_000126

Prestwick2_000126

Prestwick3_000126

RO 13-7224

RO 13-7225

RTI1169-1-1

RTI1172-1-1

RTI1173-1-1

RTI1174-1-1

RTI1188-1-1

RTI1189-1-1

Racemic mefloquine

Ro 21-5998

Ro 21-5998 (Hydrochloride)

Ro 215998

Ro-21-5998-001

SPB-80406

SPBio_001591

SPBio_002111

SPECTRUM1503070

Spectrum2_001516

Spectrum3_000953

Spectrum4_001066

Spectrum5_001122

Spectrum_001312

UNII-TML814419R

WR 142490

WR-142,490

WR-142490

WR-177,602

[(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol

[2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol

alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol

alpha-2-Piperidyl-2,8-bis(trifluoromethyl)quinoline-4-methanol

mefloquine

nchembio.215-comp3

nchembio.87-comp20

Anti-HIV Agents

Phase 2

3100

Antimetabolites, Antineoplastic

Phase 2

7171

Anti-Retroviral Agents

Phase 2

3232

Immunoglobulins

Phase 2

6045

topoisomerase I inhibitors

Phase 2

1328

Antimetabolites

Phase 2

11774

Reverse Transcriptase Inhibitors

Phase 2

1880

Nucleic Acid Synthesis Inhibitors

Phase 2

4855

Antibodies

Phase 2

6045

Topoisomerase Inhibitors

Phase 2

4945

Antibodies, Monoclonal

Phase 2

3795

Interventional clinical trials:

(show all 26)

id	Name	Status	NCT ID	Phase
1	Methylprednisolone During the Switch Between Natalizumab and Fingolimod	Recruiting	NCT02769689	Phase 4
2	Difference in Efficacy of Natalizumab Versus Fingolimod for the Treatment of Multiple Sclerosis	Recruiting	NCT01981161	Phase 4
3	Safety and Effectiveness of Switching Relapsing MS Patients Treated With Natalizumab at Risk for PML to Teriflunomide	Active, not recruiting	NCT01970410	Phase 4
4	Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS)	Terminated	NCT01211665	Phase 4
5	Natalizumab De-escalation to Interferon-beta-1b in Patients With Relapsing-remitting Multiple Sclerosis	Terminated	NCT01701856	Phase 4
6	Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125)	Completed	NCT00120367	Phase 2
7	Comparison of Anti HIV Drugs Used Alone or in Combination With Cytosine Arabinoside to Treat Progressive Multifocal Leukoencephalopathy (PML) in HIV-Infected Patients	Completed	NCT00001048	Phase 2
8	Safety and Effectiveness of Topotecan HCl to Treat HIV-Infected Patients With AIDS-Related Progressive Multifocal Leukoencephalopathy (PML)	Completed	NCT00002395	Phase 2
9	Long Term Safety of Vedolizumab (MLN0002) in Patients With Ulcerative Colitis and Crohn's Disease	Completed	NCT00619489	Phase 2
10	Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML)	Terminated	NCT00746941	Phase 1, Phase 2
11	Long-term Efficacy and Safety of Repeated Ofatumumab Treatment Courses in RA Patients Who Previously Received Ofatumumab or Placebo in Trial Hx-CD20-403	Terminated	NCT00655824	Phase 2
12	Drug Exposure Registry for GSK2248761, an Investigational NNRTI	Unknown status	NCT01458132
13	A Pilot Study of the Efficacy of Recombinant Alpha Interferon (IFN-A2b) and Zidovudine (AZT) in the Treatment of Progressive Multifocal Leukoencephalopathy (PML) Complicating HIV-1 Infection	Completed	NCT00002270
14	A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients	Completed	NCT00000945
15	Retrospective Study of the Survival of Patients Suffering From Hiv-related Progressive Multifocal Leukoencephalopathy	Completed	NCT02895581
16	Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome	Completed	NCT00342602
17	JC Virus Reactivation in Multiple Sclerosis	Completed	NCT02004444
18	A Study of ddI in Patients With AIDS Who Become Sicker While Taking Zidovudine	Completed	NCT00002274
19	JC Virus Antibody Study of Participants With Relapsing Forms of MS Receiving Treatment With Natalizumab	Completed	NCT01070836
20	Pharmacokinetic, Immunological and Biochemical Sample Collection and Analysis of a Tysabri Patient Cohort	Completed	NCT01070719
21	Analysis of Lymphocyte Cell Surface Adhesion Marker Expression in Natalizumab Population With Active Control	Completed	NCT01626248
22	Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)	Recruiting	NCT01730131
23	Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells	Recruiting	NCT02694783	Early Phase 1
24	Evaluating Nulojix (Belatacept) Long-Term Safety in Transplant	Recruiting	NCT01386359
25	Role of Inflammation in Progressive Multifocal Leukoencephalopathy (PML)	Enrolling by invitation	NCT01132053
26	Genetic Evaluation of Natalizumab-Treated Patients With Progressive Multifocal Leukoencephalopathy	Terminated	NCT01211639

Search NIH Clinical Center for Progressive Multifocal Leukoencephalopathy

Cochrane evidence based reviews: leukoencephalopathy, progressive multifocal

Genetic Tests for Progressive Multifocal Leukoencephalopathy

Anatomical Context for Progressive Multifocal Leukoencephalopathy

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Progressive Multifocal Leukoencephalopathy:

³⁶

Brain, T cells, Kidney, Liver, Lung, Testes, B cells

Publications for Progressive Multifocal Leukoencephalopathy

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Progressive Multifocal Leukoencephalopathy:

(show top 50) (show all 635)

id	Title	Authors	Year
1	Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy. (27795410)	Takahashi K.... Katano H.	2017
2	The Risk of Progressive Multifocal Leukoencephalopathy in the Biologic Era: Prevention and Management. (27890176)	Molloy E.S.... Calabrese L.H.	2017
3	Progressive Multifocal Leukoencephalopathy in a Multiple Sclerosis Patient Diagnosed after Switching from Natalizumab to Fingolimod. (27994897)	Sinnecker T.... Faiss J.	2016
4	Progressive multifocal leukoencephalopathy secondary to rituximab-induced immunosuppression and the presence of John Cunningham virus: a case report and literature review. (27594961)	Kelly D.... Carney D.	2016
5	Treatment-Related Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis: A Comprehensive Review of Current Evidence and Future Needs. (27696299)	D'Amico E.... Patti F.	2016
6	Progressive multifocal leukoencephalopathy in a patient without apparent immunosuppression. (27273076)	Grewal J.... Imitola J.	2016
7	Cidofovir for treatment of progressive multifocal leukoencephalopathy in a newly diagnosed sarcoidosis patient - a valid therapeutic option? (26944175)	Ellrichmann G.... Gold R.	2016
8	Drug-associated progressive multifocal leukoencephalopathy: a clinical, radiological, and cerebrospinal fluid analysis of 326 cases. (27401179)	Maas R.P.... Wattjes M.P.	2016
9	Assessing understanding: Patients prescribed natalizumab for multiple sclerosis individual risk and symptoms of progressive multifocal leukoencephalopathy. (27862809)	Rath L.... Skibina O.	2016
10	Progressive Multifocal Leukoencephalopathy after Ibrutinib Therapy for Chronic Lymphocytic Leukemia. (27456945)	Lutz M.... Berdel W.E.	2016
11	Low-signal-intensity rim on susceptibility-weighted imaging is not a specific finding to progressive multifocal leukoencephalopathy. (26944139)	Umino M.... Sakuma H.	2016
12	Progressive multifocal leukoencephalopathy in an immunocompetent patient. (27042682)	van der Kolk N.M.... De Jong B.A.	2016
13	Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy. (27965904)	Punch C.... Harris P.	2016
14	Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature. (26743090)	Zerbe C.S.... Holland S.M.	2016
15	Progressive Multifocal Leukoencephalopathy with Balanced CD4/CD8 T-Cell Infiltration and Good Response to Mefloquine Treatment. (27301518)	Sanjo N.... Yokota T.	2016
16	Progressive Multifocal Leukoencephalopathy in a Lung Transplant Recipient: Isolation of John Cunningham (JC) Virus from Bronchoalveolar Lavage. (27013844)	Panchabhai T.S.... Mehta A.C.	2016
17	Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus: a systematic literature review. (26743322)	Henegar C.E.... Haight B.	2016
18	Progressive multifocal leukoencephalopathy in a patient with silicosis. (27416854)	Bonnet A.... Gasnault J.	2016
19	Expression of Signaling Molecules in Progressive Multifocal Leukoencephalopathy. (26531763)	Wollebo H.S.... White M.K.	2016
20	Neuropathology of JC virus infection in progressive multifocal leukoencephalopathy in remission. (26870672)	Santacruz K.S.... Bearer E.L.	2016
21	Natalizumab-Related Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis: Findings from an Italian Independent Registry. (27997580)	Prosperini L.... Capra R.	2016
22	Drug-induced progressive multifocal leukoencephalopathy: a case/noncase study in the French pharmacovigilance database. (27736027)	Colin O.... PAcrault-Pochat M.C.	2016
23	Treatment of Progressive Multifocal Leukoencephalopathy With Mirtazapine. (27401779)	Jamilloux Y.... SA"ve P.	2016
24	CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy. (27815407)	Pignolet B.... Brassat D.	2016
25	Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis. (27817117)	Laukoter S.... Bauer J.	2016
26	Rehabilitation outcome of progressive multifocal leukoencephalopathy in HIV-positive patients: a report of two cases. (27539012)	Moreh E.... Meiner Z.	2016
27	Rituximab versus fingolimod after natalizumab in multiple sclerosis: Also consider progressive multifocal leukoencephalopathy risk. (27554031)	Marignier R.... Vukusic S.	2016
28	Poster 346 Rehabilitation of Progressive Multifocal Leukoencephalopathy: A Case Report. (27673097)	Nguyen B.T.... Feng A.	2016
29	Progressive Multifocal Leukoencephalopathy in a HIV Negative, Immunocompetent Patient. (27529042)	Nanda T.	2016
30	A case of progressive multifocal leukoencephalopathy with Takayasu arteritis and indolent adult T-cell lymphoma/leukemia. (26797479)	Fukumoto S.... Tsujino A.	2016
31	Predictors of severity and functional outcome in natalizumab-associated progressive multifocal leukoencephalopathy. (27600113)	Hoepner R.... Gold R.	2016
32	Primary cerebellar progressive multifocal leukoencephalopathy (PML) shows increased accumulation in (123)I-IMP SPECT. (26810523)	Fukami S.... Kohno M.	2016
33	Progressive multifocal leukoencephalopathy associated with infliximab. (27959350)	Sammut L.... Holroyd C.	2016
34	Use of interleukin-2 for management of natalizumab-associated progressive multifocal leukoencephalopathy: case report and review of literature. (27134676)	Dubey D.... Greenberg B.	2016
35	Single-molecule sequencing reveals the presence of distinct JC polyomavirus populations in patients with progressive multifocal leukoencephalopathy. (27571907)	SeppAolAo H.... Auvinen E.	2016
36	Re-evaluating the incidence of natalizumab-associated progressive multifocal leukoencephalopathy. (27456891)	Borchardt J.... Berger J.R.	2016
37	JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection. (27191595)	Wharton K.A.... Goelz S.E.	2016
38	Sequential Onset of Varicella-Zoster Virus Encephalomeningitis and Progressive Multifocal Leukoencephalopathy in an Allogeneic Hematopoietic Stem Cell Transplant Recipient. (27938314)	Yamashita Y.... Ishikawa J.	2016
39	A case of progressive multifocal leukoencephalopathy with chronic renal failure, whose JC virus in cerebrospinal fluid disappeared after mefloquine-mirtazapine dual therapy. (27645758)	Ohnuki E.... Kosaka S.	2016
40	Diagnostic delay in progressive multifocal leukoencephalopathy. (27231708)	Miskin D.P.... Koralnik I.J.	2016
41	Detection of cases of progressive multifocal leukoencephalopathy associated with new biologicals and targeted cancer therapies from the FDA's adverse event reporting system. (27268272)	Raisch D.W.... Bennett C.L.	2016
42	Natalizumab-associated progressive multifocal leukoencephalopathy: successful treatment without plasma exchange and its associated risks. (28039520)	Maloney E.... McGuigan C.	2016
43	Progressive Multifocal Leukoencephalopathy in HIV-Uninfected Individuals. (27686675)	Saylor D.... Venkatesan A.	2016
44	Possible pitfalls in the diagnostic of progressive multifocal leukoencephalopathy. (26754416)	Zivanovic M.... Popovic M.	2016
45	Natalizumab-Related Progressive Multifocal Leukoencephalopathy-Immune Reconstitution Inflammatory Syndrome: A Case Report Highlighting Clinical and MRI Features. (27904430)	Purohit B.... Kollias S.S.	2016
46	Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals. (26727910)	Crossley K.M.... Brew B.J.	2016
47	Progressive Multifocal Leukoencephalopathy and Systemic Lupus Erythematosus: Focus on Etiology. (27065427)	Berntsson S.G.... Moraes-Fontes M.F.	2016
48	Clearance of cerebrospinal fluid JCV DNA with mirtazapine in a patient with progressive multifocal leukoencephalopathy and sarcoidosis. (26857363)	Trentalange A.... Imperiale D.	2016
49	Progressive multifocal leukoencephalopathy after autologous peripheral blood stem cell transplantation in a patient with multiple myeloma treated with combination therapy. (27538654)	Yokokawa K.... Shimohama S.	2016
50	Progressive multifocal leukoencephalopathy with bilateral middle cerebellar peduncle lesions confirmed by repeated CSF-JC virus tests and coexistence of JC virus granule cell neuronopathy. Report of a case. (27356732)	Ito D.... Takahashi A.	2016

Genes related to Progressive Multifocal Leukoencephalopathy

Sources:
¹³DISEASES, ²¹GeneCards, ⁵⁰Novoseek
See all MalaCards sources

Genes related to Progressive Multifocal Leukoencephalopathy:

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	ITGA4	Integrin Subunit Alpha 4	32.04	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Publications (show sections)	20442571, 16827596, 16932490 more 15947080, 16917232
2	HTR2A	5-Hydroxytryptamine Receptor 2A	28.03	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Publications (show sections)	18194091
3	TNF	Tumor Necrosis Factor	23.03	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
4	IGHMBP2	Immunoglobulin Mu Binding Protein 2	22.86	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
5	IL2	Interleukin 2	21.84	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
6	CD40LG	CD40 Ligand	21.66	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
7	STAT1	Signal Transducer And Activator Of Transcription 1	21.35	DISEASES inferred ¹³ GeneCards inferred via : Publications (show sections)
8	MBP	Myelin Basic Protein	20.74	DISEASES inferred ¹³ Novoseek inferred ⁵⁰	7535576
9	RPS27A	Ribosomal Protein S27a	18.01	GeneCards inferred via : Publications (show sections)
10	MECP2	Methyl-CpG Binding Protein 2	18.01	GeneCards inferred via : Publications (show sections)
11	PDCD1	Programmed Cell Death 1	18.01	GeneCards inferred via : Publications (show sections)

Variations for Progressive Multifocal Leukoencephalopathy

Expression for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Progressive Multifocal Leukoencephalopathy.

Pathways for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁸QIAGEN, ⁵⁹R&D Systems, ⁶⁰Reactome, ⁶⁵Thomson Reuters, ⁶⁶Tocris Bioscience
See all MalaCards sources

Pathways related to Progressive Multifocal Leukoencephalopathy according to GeneCards Suite gene sharing:

(show all 18)

id	Super pathways	Score	Top Affiliating Genes
1	Immune response_MIF-mediated glucocorticoid regulation⁶⁵	9.8	IL2, TNF
2	Cytokines and Inflammatory Response⁴²	9.8	IL2, TNF
3	Inflammatory Response Pathway⁴²	9.7	CD40LG, IL2
4	Innate Lymphoid Cell Differentiation Pathways⁵⁹	9.5	IL2, ITGA4, TNF
5	Calcineurin-regulated NFAT-dependent transcription in lymphocytes⁴² Show member pathways Calcium signaling in the CD4+ TCR pathway⁴²	9.4	CD40LG, IL2, TNF
6	G-protein signaling_RhoB regulation pathway⁶⁵	9.4	CD40LG, IL2, TNF
7	MAPK Pathway⁶⁶ Show member pathways Toll-like Receptor Pathway⁶⁶	9.4	IL2, ITGA4, STAT1
8	IL27-mediated signaling events⁴² Show member pathways IL-12 Family Signaling Pathways⁵⁹ Th1 Differentiation Pathway⁵⁹	9.3	IL2, STAT1, TNF
9	Immune response IFN alpha/beta signaling pathway⁶⁵ Show member pathways Interferon alpha/beta signaling⁶⁰ Regulation of IFNA signaling⁶⁰ Cytokine Network⁵⁸	9.3	IL2, STAT1, TNF
10	Cell adhesion molecules (CAMs)³⁴	9.3	CD40LG, ITGA4, PDCD1
11	Spinal Cord Injury⁴²	9.3	IL2, MBP, TNF
12	TNF signaling (REACTOME)⁶⁰ Show member pathways TNF receptor signaling pathway⁴² Death Receptor Signalling⁶⁰ TNF signaling⁶⁰ TNFR1-mediated ceramide production⁶⁰ TNFR1-induced NFkappaB signaling pathway⁶⁰ Regulation of TNFR1 signaling⁶⁰ TNFR1-induced proapoptotic signaling⁶⁰	9.1	RPS27A, STAT1, TNF
13	SIDS Susceptibility Pathways⁴²	9.0	HTR2A, MECP2, TNF
14	Toxoplasmosis³⁴ Show member pathways Leishmaniasis³⁴	9.0	CD40LG, ITGA4, STAT1, TNF
15	IgA-Producing B Cells in the Intestine⁵⁹	8.9	CD40LG, ITGA4, PDCD1, TNF
16	B cell receptor signaling pathway (KEGG)⁴² ³⁴ Show member pathways B Cell Receptor Signaling Pathway⁴² BCR signaling pathway⁴² T cell receptor signaling pathway³⁴ B cell receptor signaling pathway³⁴ TCR Signaling Pathway⁴²	8.8	CD40LG, IL2, PDCD1, TNF
17	Allograft rejection⁴² ³⁴ Show member pathways Allograft Rejection⁴² Viral myocarditis³⁴ Asthma³⁴ CTL Mediated Apoptosis⁵⁸ Intestinal immune network for IgA production³⁴ Graft-versus-host disease³⁴ Autoimmune thyroid disease³⁴ Type I diabetes mellitus³⁴ THC Differentiation Pathway⁵⁸ Antigen processing and presentation³⁴	8.6	CD40LG, IL2, ITGA4, STAT1, TNF
18	NF-kappaB Signaling³	8.4	CD40LG, IL2, PDCD1, STAT1, TNF

GO Terms for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Biological processes related to Progressive Multifocal Leukoencephalopathy according to GeneCards Suite gene sharing:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte tethering or rolling	GO:0050901	10.6	ITGA4, TNF
2	leukocyte cell-cell adhesion	GO:0007159	10.5	CD40LG, ITGA4
3	cellular response to cytokine stimulus	GO:0071345	10.5	ITGA4, STAT1
4	regulation of immunoglobulin secretion	GO:0051023	10.3	CD40LG, TNF
5	regulation of tumor necrosis factor-mediated signaling pathway	GO:0010803	10.1	RPS27A, TNF
6	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.7	CD40LG, RPS27A, TNF
7	negative regulation of apoptotic process	GO:0043066	9.2	CD40LG, IL2, PDCD1, RPS27A
8	positive regulation of cell proliferation	GO:0008284	9.1	HTR2A, IL2, MECP2, STAT1
9	tumor necrosis factor-mediated signaling pathway	GO:0033209	8.7	CD40LG, RPS27A, STAT1, TNF