Progressive Multifocal Leukoencephalopathy disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Progressive Multifocal Leukoencephalopathy

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ⁴³NINDS, ⁶⁴Wikipedia, ³²MalaCards
See all sources

NIH Rare Diseases:⁴² Progressive multifocal leukoencephalopathy (pml) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. it is caused by the jc virus (jcv). by age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened. the disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as hodgkin’s disease, lymphoma, and sarcoidosis. pml is most common among individuals with acquired immune deficiency syndrome (aids). last updated: 4/1/2011

MalaCards based summary: Progressive Multifocal Leukoencephalopathy, also known as leukoencephalopathy, progressive multifocal, is related to multiple sclerosis and systemic lupus erythematosus. An important gene associated with Progressive Multifocal Leukoencephalopathy is IGHMBP2 (immunoglobulin mu binding protein 2), and among its related pathways is Cell adhesion molecules (CAMs). The compounds phorbol 12,13-dibutyrate and infliximab have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and kidney, and related mouse phenotypes are cellular and hematopoietic system.

Disease Ontology:⁹ A viral infectious disease that involves reactivation of jc polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. the symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.

NINDS:⁴³ Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection that targets cells that make myelin--the material that insulates nerve cells (neurons).

Wikipedia:⁶⁴ Progressive multifocal leukoencephalopathy (or leucoencephalopathy in the U.K. and Australia) (PML),... more...

Aliases & Classifications for Progressive Multifocal Leukoencephalopathy

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ⁴³NINDS, ¹¹DISEASES, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁶¹UMLS, ⁵⁶SNOMED-CT, ³⁴MeSH, ²⁸ICD9CM, ³⁹NCIt, ³⁵MESH via Orphanet, ⁶²UMLS via Orphanet, ²⁶ICD10
See all sources

Progressive Multifocal Leukoencephalopathy, Aliases & Descriptions:

Name: Progressive Multifocal Leukoencephalopathy ⁹ ⁴² ⁴³ ¹¹ ⁴⁸

Leukoencephalopathy, Progressive Multifocal ⁴² ⁶¹

Leukoencephalopathy Progressive Multifocal ⁴⁴

Progressive Multifocal Leukoencephalitis ⁴⁸

Pml ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases

ICD10: ²⁶

Certain infectious and parasitic diseases

Viral infections of the central nervous system

Atypical virus infections of central nervous system

Progressive multifocal leukoencephalopathy

Orphanet: ⁴⁸

Rare neurological diseases

Rare infectious diseases

Characteristics (Orphanet epidemiological data):

⁴⁸

progressive multifocal leukoencephalopathy:
Inheritance: Sporadic; Age of onset: Variable

External Ids:

Disease Ontology⁹ DOID:643

MeSH³⁴ D007968

ICD9CM²⁸ 046.3

NCIt³⁹ C26815

SNOMED-CT⁵⁶ 22255007

MESH via Orphanet³⁵ D007968

UMLS via Orphanet⁶² C0023524

ICD10²⁶ A81.2

UMLS⁶¹ C0023524

Related Diseases for Progressive Multifocal Leukoencephalopathy

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Progressive Multifocal Leukoencephalopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 155)

id	Related Disease	Score	Top Affiliating Genes
1	multiple sclerosis	31.2	PDCD1, ITGA4, LBR
2	systemic lupus erythematosus	30.9	PDCD1, ITGA4, LBR
3	chronic lymphocytic leukemia	30.7	ITGA4, PNP
4	vasculitis	30.7	TAT, ITGA4
5	lymphopenia	30.5	LBR, PNP
6	encephalitis	30.4	TAT, ITGA4
7	kaposi's sarcoma	30.4	TAT, LBR
8	leukemia	30.3	ITGA4, PNP, LBR
9	rheumatoid arthritis	30.2	LBR, PNP, ITGA4, PDCD1
10	non-hodgkin lymphoma	30.1	TAT, ITGA4, PNP, LBR
11	primary biliary cirrhosis	30.0	LBR, PDCD1
12	herpes simplex	29.9	TAT, PNP, LBR
13	acute promyelocytic leukemia	11.0
14	lupus erythematosus	10.7
15	sarcoidosis	10.6
16	acquired immunodeficiency syndrome	10.6
17	rheumatic disease	10.6
18	arthritis	10.5
19	t-lymphocytopenia	10.5
20	follicular lymphoma	10.5
21	hiv-1	10.5
22	tremor	10.5
23	b-cell lymphomas	10.4
24	crohn's disease	10.4
25	hodgkin's lymphoma	10.4
26	neuronitis	10.4
27	myeloma	10.4
28	hiv/aids	10.3
29	multiple myeloma	10.3
30	wiskott-aldrich syndrome	10.3
31	cortical blindness	10.3
32	cerebritis	10.3
33	demyelinating disease	10.3
34	meningitis	10.3
35	psoriasis	10.3
36	polymyositis	10.3
37	blindness	10.3
38	prostatitis	10.3
39	sarcoma	10.3
40	prostate cancer	10.3
41	myeloid leukemia	10.3
42	acute myeloid leukemia	10.2
43	breast cancer	10.2
44	endotheliitis	10.2
45	acute lymphocytic leukemia	10.2
46	common variable immunodeficiency	10.2
47	diffuse large b-cell lymphoma	10.2
48	graft versus host disease	10.2
49	hematopoietic stem cell transplantation	10.2
50	hepatitis	10.2

Graphical network of the top 20 diseases related to Progressive Multifocal Leukoencephalopathy:

Symptoms for Progressive Multifocal Leukoencephalopathy

Drugs & Therapeutics for Progressive Multifocal Leukoencephalopathy

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Progressive Multifocal Leukoencephalopathy

Search NIH Clinical Center for Progressive Multifocal Leukoencephalopathy

Genetic Tests for Progressive Multifocal Leukoencephalopathy

Anatomical Context for Progressive Multifocal Leukoencephalopathy

Sources:
³²MalaCards
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MalaCards organs/tissues related to Progressive Multifocal Leukoencephalopathy:

³²

Brain, T cells, Kidney, Liver, Lung, B cells, Bone marrow, Bone, Spinal cord, Testes, Cortex, Heart

Animal Models for Progressive Multifocal Leukoencephalopathy or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Progressive Multifocal Leukoencephalopathy:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	8.1	PDCD1, ITGA4, PNP, LBR
2	hematopoietic system phenotype	MP:0005397	8.0	LBR, PNP, ITGA4, PDCD1
3	immune system phenotype	MP:0005387	7.8	LBR, PNP, ITGA4, PDCD1
4	mortality/aging	MP:0010768	7.6	PDCD1, ITGA4, PNP, IGHMBP2, LBR

Publications for Progressive Multifocal Leukoencephalopathy

Sources:
⁵¹PubMed
See all sources

Articles related to Progressive Multifocal Leukoencephalopathy:

(show top 50) (show all 535)

id	Title	Authors	Year
1	Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy. (25273271)	Plavina T.... Ticho B.	2014
2	Progressive multifocal leukoencephalopathy in a patient with chronic lymphocytic leukaemia treated with alemtuzumab. (24403383)	Isidoro L.... Cordeiro G.	2014
3	Progressive multifocal leukoencephalopathy in patients with sarcoidosis. (25267986)	Lefaucheur R.... Bourre B.	2014
4	Partial recovery after severe immune reconstitution inflammatory syndrome in a multiple sclerosis patient with progressive multifocal leukoencephalopathy. (24341880)	Calvi A.... Scarpini E.	2014
5	Treatment of progressive multifocal leukoencephalopathy. (23345466)	O'Brien M.	2013
6	Progressive multifocal leukoencephalopathy in patients with multiple sclerosis. (23493158)	Baldwin K.J.... Hogg J.P.	2013
7	Isolated cortical blindness without simultaneous neurological involvement in progressive multifocal leukoencephalopathy in a patient with human immune deficiency virus infection. (23514446)	Jeyaraman V.A.... Biswas J.	2013
8	Progressive multifocal leukoencephalopathy with gastrointestinal disease in a pediatric kidney transplant recipient. (23902604)	Burke M.T.... Burke J.R.	2013
9	Progressive multifocal leukoencephalopathy: new concepts. (24141508)	Lima M.A.	2013
10	Unusual natalizumab-associated progressive multifocal leukoencephalopathy starting in the brainstem. (24276521)	Havla J.... KA1mpfel T.	2013
11	Progressive multifocal leukoencephalopathy and palliative care: a report of three cases and review of the literature. (22740610)	Cotton P.J.... Le B.	2013
12	Progressive multifocal leukoencephalopathy: clinical and molecular aspects. (21936015)	Tavazzi E.... Khalili K.	2012
13	Efficacy of mefloquine to progressive multifocal leukoencephalopathy initially presented with parkinsonism. (22209147)	Hirayama M.... Hashizume Y.	2012
14	Brentuximab associated progressive multifocal leukoencephalopathy. (22472351)	Jalan P.... Koirala J.	2012
15	JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy. (22253012)	Delbue S.... Ferrante P.	2012
16	Natalizumab-associated progressive multifocal leukoencephalopathy. (22931329)	Mancini N.... Burioni R.	2012
17	The basis for modeling progressive multifocal leukoencephalopathy pathogenesis. (21499097)	Berger J.R.	2011
18	The pathogenesis of progressive multifocal leukoencephalopathy. (22204766)	Berger J.R.... Khalili K.	2011
19	Infrequent detection of KI, WU and MC polyomaviruses in immunosuppressed individuals with or without progressive multifocal leukoencephalopathy. (21436884)	Dang X.... Tan C.S.	2011
20	Progressive multifocal leukoencephalopathy in liver transplant recipients: a case report and review of the literature. (21134241)	Verhelst X.... Orlent H.	2011
21	Progressive multifocal leukoencephalopathy: can we reduce risk in patients receiving biological immunomodulatory therapies? (20818784)	Tyler K.L.	2010
22	Treatment of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia. (20961908)	Patel A.... Ikwuagwu J.	2010
23	Comment to: Progressive Multifocal Leukoencephalopathy and Other Disorders Caused by JC Virus: Clinical Features and Pathogenesis : C. D. Tan, I. J. Koralnik Lancet Neurol 2010;9:425-37. (20512302)	Urbach H.	2010
24	Progressive multifocal leukoencephalopathy in HIV-2 infection. Case report. (20452275)	Duque V.... MeliAso-Sivestre A.	2010
25	Incidence of progressive multifocal leukoencephalopathy in patients without HIV. (20938025)	Amend K.L.... Seeger J.	2010
26	Detection of WU polyomavirus in cerebrospinal fluid specimen from a patient with AIDS and suspected progressive multifocal leukoencephalopathy. (19530941)	Barzon L.... PalA^ G.	2009
27	Follow-up magnetic resonance imaging findings in patients with progressive multifocal leukoencephalopathy: evaluation of long-term survivors under highly active antiretroviral therapy. (19373535)	Sakai M.... Nakamura H.	2009
28	Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study. (19007313)	Engsig F.N.... Obel N.	2009
29	Progressive multifocal leukoencephalopathy--incidental finding in the forensic neuropathological examination. (19216217)	Lucena J.... Cruz-SA!nchez F.F.	2009
30	WU and KI polyomaviruses in the brains of HIV-positive patients with and without progressive multifocal leukoencephalopathy. (19860559)	Barzon L.... PalA^ G.	2009
31	Rearrangement of the JC virus regulatory region sequence in the bone marrow of a patient with rheumatoid arthritis and progressive multifocal leukoencephalopathy. (18989816)	Marzocchetti A.... Koralnik I.J.	2008
32	Progressive multifocal leukoencephalopathy in purine nucleoside phosphorylase deficiency. (16949240)	Parvaneh N.... Parvaneh L.	2007
33	Non-HIV-related progressive multifocal leukoencephalopathy (PML): a tertiary cancer center experience. (17238872)	Chowdhary S.... Chamberlain M.	2007
34	Inflammatory progressive multifocal leukoencephalopathy in human immunodeficiency virus-negative patients. (17328067)	Huang D.... Ransohoff R.M.	2007
35	Central nervous system graft-versus-host disease: consider progressive multifocal leukoencephalopathy among the differential diagnoses. (17922040)	Focosi D.... Ceccherini-Nelli L.	2007
36	Potential risk of progressive multifocal leukoencephalopathy with natalizumab therapy: possible interventions. (17296831)	StA1ve O.... Hemmer B.	2007
37	Multiple sclerosis, natalizumab therapy, and progressive multifocal leukoencephalopathy. (16914971)	Bartt R.E.	2006
38	Progressive multifocal leukoencephalopathy: prolonged survival in patients treated with protease inhibitors and cidofovir: a case series. (16514320)	Garvey L.... Taylor G.P.	2006
39	Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. (16798673)	WA1thrich C.... Koralnik I.J.	2006
40	Progressive multifocal leukoencephalopathy in HIV-2-infected patient. (16816570)	Bienaime A.... Brouqui P.	2006
41	Natalizumab and progressive multifocal leukoencephalopathy: highlights of the International Workshop on JC Virus/PML and Multiple Sclerosis, June 3-4, 2005, Philadelphia PA. (16400315)	Tyler K.L.... Khalili K.	2005
42	Successful outcome of progressive multifocal leukoencephalopathy in a renal transplant patient. (15816900)	Crowder C.D.... Ramos E.	2005
43	High anti-double-stranded DNA antibodies and progressive multifocal leukoencephalopathy in a patient with systemic lupus erythematosus. (15769818)	Vandecasteele S.J.... Vanrenterghem Y.	2005
44	Rearrangement of simian virus 40 regulatory region is not required for induction of progressive multifocal leukoencephalopathy in immunosuppressed rhesus monkeys. (15650162)	Dang X.... Koralnik I.J.	2005
45	Progressive multifocal leukoencephalopathy in transplant recipients. (15616809)	Shitrit D.... Kramer M.R.	2005
46	Head tremor and progressive multifocal leukoencephalopathy in AIDS patients: report of two cases. (15830082)	Rieder C.R.... Ziomkowski S.C.	2005
47	A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. (15215217)	Du Pasquier R.A.... Koralnik I.J.	2004
48	Progressive multifocal leukoencephalopathy in a patient with chronic myelogenous leukemia. (12802840)	Swamy P.A.... Nardino R.	2003
49	Search for human herpesvirus 6 DNA in cerebrospinal fluid from AIDS patients with progressive multifocal leukoencephalopathy. (12587078)	Corral I.... Moreno S.	2003
50	Progressive multifocal leukoencephalopathy in AIDS: a clinicopathologic study and review of the literature. (8410079)	von Einsiedel R.W.... Vinters H.V.	1993

Genes related to Progressive Multifocal Leukoencephalopathy

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Progressive Multifocal Leukoencephalopathy:

- Elite gene

id	Symbol	Description	Score	Implication
1	IGHMBP2	immunoglobulin mu binding protein 2	21.77	GeneCards inferred via : Publications (show sections)
2	PDCD1	programmed cell death 1	18.43	GeneCards inferred via : Publications (show sections)
3	TAT	tyrosine aminotransferase	15.10	GeneCards inferred via : Publications (show sections)
4	LBR	lamin B receptor	11.77	GeneCards inferred via : Publications (show sections)
5	PNP	purine nucleoside phosphorylase	8.43	GeneCards inferred via : Publications (show sections)
6	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	5.10	GeneCards inferred via : Publications, Disorders (show sections)

Products for genes related to Progressive Multifocal Leukoencephalopathy disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	5	-	5	5
2	Novus Biologicals	5	5	5	-

Variations for Progressive Multifocal Leukoencephalopathy

Expression for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Progressive Multifocal Leukoencephalopathy

Search GEO for disease gene expression data for Progressive Multifocal Leukoencephalopathy.

Pathways for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
⁴⁹PathCards, ³⁰KEGG
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Pathways related to Progressive Multifocal Leukoencephalopathy according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)³⁰	9.5	PDCD1, ITGA4

Compounds for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
⁴⁴Novoseek, ⁵⁰PharmGKB, ¹²DrugBank, ²⁹IUPHAR, ⁶⁰Tocris Bioscience, ²⁵HMDB, ³BitterDB
See all sources

Compounds related to Progressive Multifocal Leukoencephalopathy according to GeneCards/GeneDecks:

(show all 29)

id	Compound	Score	Top Affiliating Genes
1	phorbol 12,13-dibutyrate⁴⁴	9.7	LBR, ITGA4
2	infliximab⁴⁴ ⁵⁰ ¹²	11.7	LBR, ITGA4
3	zidovudine⁴⁴ ⁵⁰ ¹²	11.6	LBR, TAT
4	lead⁴⁴	9.6	ITGA4, TAT
5	vitamin-e⁴⁴	9.6	TAT, LBR
6	mifepristone⁴⁴ ²⁹ ⁶⁰ ¹²	12.6	LBR, TAT
7	vincristine⁴⁴ ⁵⁰ ¹²	11.6	TAT, ITGA4
8	gold⁴⁴	9.4	TAT, LBR
9	guanosine⁴⁴ ²⁵ ¹²	11.4	TAT, PNP
10	uridine⁴⁴ ²⁵ ¹²	11.4	TAT, PNP
11	didanosine⁴⁴ ⁵⁰ ¹²	11.4	PNP, LBR
12	dithiothreitol⁴⁴	9.4	PNP, ITGA4
13	ribavirin⁴⁴ ⁵⁰ ¹²	11.4	PNP, LBR
14	inositol⁴⁴	9.3	LBR, TAT
15	purine⁴⁴ ²⁵	10.2	PNP, LBR
16	adenine⁴⁴ ²⁵ ¹²	11.2	TAT, PNP
17	pentoxifylline⁴⁴ ¹²	10.2	TAT, ITGA4, LBR
18	rantes⁴⁴	9.2	LBR, ITGA4, TAT
19	genistein⁴⁴ ²⁹ ⁶⁰ ³ ²⁵ ¹²	14.2	TAT, ITGA4, LBR
20	heparin⁴⁴ ²⁹ ²⁵ ¹²	12.1	LBR, ITGA4, TAT
21	cycloheximide⁴⁴	9.1	LBR, ITGA4, TAT
22	arsenite⁴⁴ ²⁵	10.0	PNP, LBR
23	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	12.0	TAT, ITGA4, LBR
24	aspartate⁴⁴	9.0	TAT, ITGA4, PNP
25	retinoic acid⁴⁴ ²⁵	9.7	TAT, ITGA4, LBR
26	glucose⁴⁴	8.4	TAT, ITGA4, PNP, LBR
27	serine⁴⁴	8.3	TAT, ITGA4, PNP, LBR
28	cysteine⁴⁴	8.2	TAT, PNP, LBR
29	tyrosine⁴⁴	7.9	TAT, PDCD1, ITGA4, PNP, LBR