|
PML
MCID: PRG009
|
Progressive Multifocal Leukoencephalopathy (PML) malady |
|
Sources: 8Disease Ontology, 39NIH Rare Diseases, 40NINDS, 59Wikipedia, 29MalaCards See all sources Fully expand this MalaCard Export this MalaCard |
NIH Rare Diseases:39 Progressive multifocal leukoencephalopathy (pml) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. it is caused by the jc virus (jcv). by age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened. the disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as hodgkinâs disease, lymphoma, and sarcoidosis. pml is most common among individuals with acquired immune deficiency syndrome (aids).
MalaCards: Progressive Multifocal Leukoencephalopathy, also known as leukoencephalopathy, progressive multifocal, is related to kaposi's sarcoma and purine nucleoside phosphorylase deficiency. An important gene associated with Progressive Multifocal Leukoencephalopathy is IGHMBP2 (immunoglobulin mu binding protein 2), and among its related pathways are adenine and adenosine salvage III and purine nucleotides degradation II (aerobic). The compounds deoxyinosine and 9-(beta-d-arabinofuranosyl)guanine have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and kidney, and related mouse phenotypes are respiratory system and behavior/neurological. Disease Ontology:8 A viral infectious disease that involves reactivation of jc polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. the symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma. NINDS:40 Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection that targets cells that make myelin--the material that insulates nerve cells (neurons). Wikipedia:59 Progressive multifocal leukoencephalopathy (PML), also known as progressive multifocal... more... |
|
Sources: 8Disease Ontology, 39NIH Rare Diseases, 40NINDS, 10DISEASES, 41Novoseek, 45Orphanet, 56UMLS, 36NCIt, 52SNOMED-CT, 31MeSH, 25ICD9CM, 32MESH via Orphanet, 53SNOMED-CT via Orphanet, 57UMLS via Orphanet, 23ICD10 See all sources |
|
|
|
Sources: 5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 56UMLS, 37NDF-RT See all sources |
Approved drugs:Search CenterWatch for progressive multifocal leukoencephalopathy Drug clinical trials:Search ClinicalTrials for progressive multifocal leukoencephalopathy Search NIH Clinical Center for progressive multifocal leukoencephalopathy Search CenterWatch for progressive multifocal leukoencephalopathy |
|
|
|
Sources: 29MalaCards See all sources |
MalaCards organs/tissues related to progressive multifocal leukoencephalopathy:29Brain, Kidney, T cells
|
|
Sources: 33MGI, 26inGenious Targeting Laboratory See all sources |
MGI Mouse Phenotypes related to progressive multifocal leukoencephalopathy:33
|
|
Sources: 47PubMed See all sources |
Articles related to progressive multifocal leukoencephalopathy:(show all 19)
|
|
Sources: 16GeneCards, 42Novus Biologicals, 26inGenious Targeting Laboratory See all sources |
Genes related to progressive multifocal leukoencephalopathy:(show all 20)
Products for genes related to progressive multifocal leukoencephalopathy disease:
|
|
|
|
Sources: 1BioGPS See all sources |
  |
|
Sources: 34NCBI BioSystems Database, 27KEGG, 50Reactome See all sources |
|
Sources: 41Novoseek, 22HMDB, 11DrugBank, 55Tocris Bioscience, 46PharmGKB See all sources |
Compounds related to progressive multifocal leukoencephalopathy according to GeneCards/GeneDecks:(show all 18)
|
|
Sources: 15Gene Ontology See all sources |
|
