Progressive Multifocal Leukoencephalopathy disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Progressive Multifocal Leukoencephalopathy

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ⁴³NINDS, ⁶³Wikipedia, ³²MalaCards
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NIH Rare Diseases:⁴² Progressive multifocal leukoencephalopathy (pml) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. it is caused by the jc virus (jcv). by age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened. the disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as hodgkinâs disease, lymphoma, and sarcoidosis. pml is most common among individuals with acquired immune deficiency syndrome (aids). last updated: 4/1/2011

MalaCards: Progressive Multifocal Leukoencephalopathy, also known as leukoencephalopathy, progressive multifocal, is related to multiple sclerosis and leukemia. An important gene associated with Progressive Multifocal Leukoencephalopathy is IGHMBP2 (immunoglobulin mu binding protein 2), and among its related pathways is purine nucleotides degradation II (aerobic). The compounds deoxyinosine and 9-(beta-d-arabinofuranosyl)guanine have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and kidney, and related mouse phenotypes are skeleton and respiratory system.

Disease Ontology:⁸ A viral infectious disease that involves reactivation of jc polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. the symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.

NINDS:⁴³ Progressive multifocal leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by a virus infection that targets cells that make myelin--the material that insulates nerve cells (neurons).

Wikipedia:⁶³ Progressive multifocal leukoencephalopathy (PML), also known as progressive multifocal... more...

Aliases & Classifications for Progressive Multifocal Leukoencephalopathy

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ⁴³NINDS, ¹⁰DISEASES, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁶⁰UMLS, ³⁴MeSH, ²⁷ICD9CM, ³⁹NCIt, ⁵⁶SNOMED-CT, ⁶¹UMLS via Orphanet, ³⁵MESH via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ²⁵ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases

ICD10: ²⁵

Certain infectious and parasitic diseases

Viral infections of the central nervous system

Atypical virus infections of central nervous system

Progressive multifocal leukoencephalopathy

Characteristics (Orphanet epidemiological data):

⁴⁸

progressive multifocal leukoencephalopathy:
Inheritance: Sporadic; Age of onset: Variable

Aliases & Descriptions:

progressive multifocal leukoencephalopathy ⁸ ⁴² ⁴³ ¹⁰ ⁴⁸

leukoencephalopathy, progressive multifocal ⁴² ⁶⁰

leukoencephalopathy progressive multifocal ⁴⁴

progressive multifocal leukoencephalitis ⁴⁸

pml ⁴²

External Ids:

Disease Ontology⁸ DOID:643

MeSH³⁴ D007968

ICD9CM²⁷ 046.3

NCIt³⁹ C26815

SNOMED-CT⁵⁶ 22255007

UMLS via Orphanet⁶¹ C0023524

MESH via Orphanet³⁵ D007968

SNOMED-CT via Orphanet⁵⁷ 22255007

ICD10²⁵ A81.2

UMLS⁶⁰ C0023524

Related Diseases for Progressive Multifocal Leukoencephalopathy

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Progressive Multifocal Leukoencephalopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 175)

id	Related Disease	Score	Top Affiliating Genes
1	multiple sclerosis	31.2	PDCD1, ITGA4, LBR
2	leukemia	31.0	PNP, ITGA4, CD9, SPIB, LBR, MECP2
3	systemic lupus erythematosus	30.9	LBR, ADA, PDCD1, ITGA4
4	acquired immunodeficiency syndrome	30.8	CARTPT, TAT
5	arthritis	30.7	TAT, ITGA4
6	rheumatoid arthritis	30.7	ADA, PDCD1, PNP, LBR, ITGA4
7	myeloma	30.6	CD9, ITGA4
8	non-hodgkin lymphoma	30.5	CT49, ITGA4, LBR, ADA, PNP, TAT
9	lymphopenia	30.4	ADA, PNP, LBR
10	kaposi's sarcoma	30.2	LBR, CD9, TAT
11	oligodendroglioma	30.2	CT49
12	purine nucleoside phosphorylase deficiency	30.2	ADA
13	aseptic meningitis	30.2	ADA, CD9
14	hepatitis c	30.2	CD9
15	encephalitis	30.2	ITGA4, CD9, TAT
16	acute lymphocytic leukemia	30.2	ADA, PNP, CD9, ITGA4
17	mycosis fungoides	30.2	ITGA4, ADA
18	schizophrenia	30.2	MECP2, FEZ1, LBR, POU3F1, PNP
19	primary biliary cirrhosis	30.2	LBR
20	retinoblastoma	30.2	TICAM2, CT49, MECP2
21	dementia	29.9	TAT, CD9
22	lupus erythematosus	10.6
23	sarcoidosis	10.6
24	chronic lymphocytic leukemia	10.5
25	adult syndrome	10.4
26	myeloid leukemia	10.4
27	crohn's disease	10.4
28	neuronitis	10.4
29	hodgkin's lymphoma	10.4
30	acute promyelocytic leukemia	10.4
31	acute myeloid leukemia	10.3
32	prostatitis	10.3
33	wiskott-aldrich syndrome	10.3
34	common variable immunodeficiency	10.3
35	t lymphocyte deficiency	10.3
36	cortical blindness	10.3
37	acute leukemia	10.3
38	central nervous system disease	10.3
39	meningitis	10.3
40	multiple myeloma	10.3
41	nervous system disease	10.3
42	psoriasis	10.3
43	vasculitis	10.3
44	rabies	10.3
45	breast cancer	10.3
46	prostate cancer	10.3
47	sarcoma	10.3
48	parotitis	10.2
49	nasopharyngitis	10.2
50	influenza	10.2

Graphical network of the top 20 diseases related to Progressive Multifocal Leukoencephalopathy:

Clinical Features for Progressive Multifocal Leukoencephalopathy

Drugs & Therapeutics for Progressive Multifocal Leukoencephalopathy

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Progressive Multifocal Leukoencephalopathy

Drug clinical trials:

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Search NIH Clinical Center for Progressive Multifocal Leukoencephalopathy

Search CenterWatch for Progressive Multifocal Leukoencephalopathy

Genetic Tests for Progressive Multifocal Leukoencephalopathy

Anatomical Context for Progressive Multifocal Leukoencephalopathy

Sources:
³²MalaCards
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MalaCards organs/tissues related to Progressive Multifocal Leukoencephalopathy:

³²

Brain, T cells, Kidney, Lung, Liver, B cells, Bone, Bone marrow, Testes, Spinal cord, Heart, Cortex

Animal Models for Progressive Multifocal Leukoencephalopathy or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Progressive Multifocal Leukoencephalopathy:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	9.8	CD9, NFIX, PDCD1, CARTPT
2	respiratory system phenotype	MP:0005388	9.6	LBR, MECP2, IGHMBP2, POU3F1, CD9, ADA
3	cellular phenotype	MP:0005384	9.2	LBR, MECP2, ADA, SPIB, PURA, PNP
4	hematopoietic system phenotype	MP:0005397	9.2	LBR, ITGA4, CD9, PNP, SPIB, ADA
5	behavior/neurological phenotype	MP:0005386	9.2	LBR, NFIX, PURA, CARTPT, MECP2, FEZ1
6	growth/size phenotype	MP:0005378	9.1	CD9, POU3F1, IGHMBP2, NFIX, MECP2, LBR
7	mortality/aging	MP:0010768	9.0	ITGA4, ADA, IGHMBP2, NFIX, MECP2, LBR
8	immune system phenotype	MP:0005387	8.9	ITGA4, TICAM2, PURA, CARTPT, MECP2, PDCD1
9	nervous system phenotype	MP:0003631	8.9	MECP2, FEZ1, PDCD1, PURA, NFIX, IGHMBP2

Publications for Progressive Multifocal Leukoencephalopathy

Sources:
⁵⁰PubMed
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Articles related to Progressive Multifocal Leukoencephalopathy:

(show top 50) (show all 517)

id	Title	Authors	Year
1	Prophylactic antiepileptic treatment reduces seizure frequency in natalizumab-associated progressive multifocal leukoencephalopathy. (24409198)	Hoepner R.... Hellwig K.	2014
2	Treatment of progressive multifocal leukoencephalopathy. (23345466)	O'Brien M.	2013
3	Presumptive Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis after Natalizumab Therapy. (23323645)	Eisele P.... Gass A.	2013
4	Progressive multifocal leukoencephalopathy developed 26 years after renal transplantation. (23253820)	Nagayama S.... Matsui M.	2013
5	Frequent infection of cortical neurons by JC virus in patients with progressive multifocal leukoencephalopathy. (22157619)	WA1thrich C.... Koralnik I.J.	2012
6	Progressive multifocal leukoencephalopathy in autoimmune diseases. (22281228)	Palazzo E.... Yahia S.A.	2012
7	Smoldering myeloma presenting as progressive multifocal leukoencephalopathy: a case report. (22747665)	Troppmann M.... Salzberger B.	2012
8	Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient. (22930304)	Adachi E.... Fujii T.	2012
9	Progressive multifocal leukoencephalopathy restricted to the posterior fossa in a patient with systemic lupus erythematosus. (22218525)	GonAsalves F.G.... Del Carpio-O'Donovan R.	2011
10	Progressive multifocal leukoencephalopathy in transplant recipients. (21823157)	Mateen F.J.... Nath A.	2011
11	Progressive multifocal leukoencephalopathy in an HIV patient receiving successful long-term HAART. (21445699)	Mascarello M.... Ferrari S.	2011
12	Progressive multifocal leukoencephalopathy: an unexpected complication of modern therapeutic monoclonal antibody therapies. (22082208)	Tavazzi E.... Khalili K.	2011
13	Progressive multifocal leukoencephalopathy (PML) after transplantation. (21235709)	Nguyen C.... Shapiro R.	2011
14	Progressive multifocal leukoencephalopathy in a patient without immunodeficiency. (21734181)	Tan I.L.... McArthur J.C.	2011
15	Early onset of natalizumab-related progressive multifocal leukoencephalopathy. (21900356)	Damasceno A.... Damasceno B.P.	2011
16	JC virus latency in the brain and extraneural organs of patients with and without progressive multifocal leukoencephalopathy. (20610709)	Tan C.S.... Koralnik I.J.	2010
17	Progressive multifocal leukoencephalopathy in a patient without apparent immunosuppression. (20920200)	Vaklavas C.... Tsimberidou A.M.	2010
18	Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies. (19719397)	Major E.O.	2010
19	Progressive multifocal leukoencephalopathy and newer biological agents. (20925435)	Berger J.R.	2010
20	A case of progressive multifocal leukoencephalopathy in a patient treated with infliximab. (20722036)	Kumar D.... Berger R.G.	2010
21	Clinicopathological study of early progressive multifocal leukoencephalopathy incidentally found in a schizophrenia patient. (19170897)	Oshima K.... Nagashima K.	2009
22	Determinants of survival in progressive multifocal leukoencephalopathy. (19901246)	Marzocchetti A.... Koralnik I.J.	2009
23	Progressive multifocal leukoencephalopathy - experimental options. (19782910)	Rock C.... Bergin C.	2009
24	Progressive multifocal leukoencephalopathy in HIV-1 infection. (19778765)	Cinque P.... Price R.W.	2009
25	A progressive neurologic disorder with multiple CNS lesions: a neuroimaging clinicopathologic correlation. Progressive multifocal leukoencephalopathy (PML). (18819185)	Chowdhary S.... Chamberlain M.	2008
26	Progressive multifocal leukoencephalopathy in a patient with idiopathic CD4+ cells deficit. (18998035)	Melzi S.... Rizzardini G.	2008
27	Infratentorial progressive multifocal leukoencephalopathy in a patient treated with fludarabine and rituximab. (18379739)	Bonavita S.... Tedeschi G.	2008
28	Progressive multifocal leukoencephalopathy. (18657729)	Weber T.	2008
29	Progressive multifocal leukoencephalopathy. (18579021)	Aksamit A.J.	2008
30	Non-HIV-related progressive multifocal leukoencephalopathy (PML): a tertiary cancer center experience. (17238872)	Chowdhary S.... Chamberlain M.	2007
31	Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy. (17229701)	Lima M.A.... Koralnik I.J.	2007
32	Progressive multifocal leukoencephalopathy mimicking central nervous system lupus. (17924609)	Roberts J.R.... Finger D.R.	2007
33	Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera. (17674313)	Verma S.... Simpson D.M.	2007
34	Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. (16798673)	WA1thrich C.... Koralnik I.J.	2006
35	Natalizumab and progressive multifocal leukoencephalopathy: migrating towards safe adhesion molecule therapy in multiple sclerosis. (16687056)	Bennett J.L.	2006
36	Progression of progressive multifocal leukoencephalopathy despite treatment with beta-interferon. (16769975)	Skromne E.... Ordonez L.	2006
37	Successful outcome of progressive multifocal leukoencephalopathy in a renal transplant patient. (15816900)	Crowder C.D.... Ramos E.	2005
38	Successful cidofovir therapy of progressive multifocal leukoencephalopathy preceding angioimmunoblastic T-cell lymphoma. (16334909)	Viallard J.F.... Pellegrin J.L.	2005
39	Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. (15947080)	van Assche G.... Rutgeerts P.	2005
40	Childhood case of progressive multifocal leukoencephalopathy with improved clinical outcome. (15832618)	Demir E.... Anlar B.	2005
41	A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. (15215217)	Du Pasquier R.A.... Koralnik I.J.	2004
42	JC virus early protein detection by immunohistochemistry in progressive multifocal leukoencephalopathy: a comparative study with in situ hybridization and polymerase chain reaction. (15581180)	MuA+oz-MA!rmol A.M.... Ariza A.	2004
43	Progressive multifocal leukoencephalopathy: cidofovir therapy in three patients with underlying hematological disease. (12814108)	Herrlinger U.... Weller M.	2003
44	Progressive multifocal leukoencephalopathy shortly after the diagnosis of follicular lymphoma in a patient treated with fludarabine. (12091141)	RodrA-guez L.... Feliu E.	2002
45	JC virus load in progressive multifocal leukoencephalopathy: analysis of the correlation between the viral burden in cerebrospinal fluid, patient survival, and the volume of neurological lesions. (12032891)	GarcA-a de Viedma D.... Bouza E.	2002
46	Fatal immune restoration disease in human immunodeficiency virus type 1-infected patients with progressive multifocal leukoencephalopathy: impact of antiretroviral therapy-associated immune reconstitution. (12410486)	Safdar A.... Waldron R.L.	2002
47	Progressive multifocal leukoencephalopathy and oligodendroglioma in a monkey co-infected by simian immunodeficiency virus and simian virus 40. (10965804)	ChrActien F.... Gray F.	2000
48	Analysis of the transcriptional control region in progressive multifocal leukoencephalopathy. (11031693)	Vaz B.... Weber T.	2000
49	Detection of JC virus in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. (9542955)	Bogdanovic G.... Dalianis T.	1998
50	Progressive multifocal leukoencephalopathy in AIDS: a clinicopathologic study and review of the literature. (8410079)	von Einsiedel R.W.... Vinters H.V.	1993

Genes related to Progressive Multifocal Leukoencephalopathy

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Progressive Multifocal Leukoencephalopathy:

(show all 37)

id	Symbol	Description	Score	Implication
1	IGHMBP2	immunoglobulin mu binding protein 2	20.28	GeneCards inferred : Publications, Disorders (show sections)
2	CARTPT	CART prepropeptide	19.74	GeneCards inferred : Disorders (show sections)
3	TAT	tyrosine aminotransferase	19.20	GeneCards inferred : Publications, Disorders (show sections)
4	IGBP1	immunoglobulin (CD79A) binding protein 1	18.66	GeneCards inferred : Disorders (show sections)
5	PNP	purine nucleoside phosphorylase	18.12	GeneCards inferred : Publications, Disorders (show sections)
6	LBR	lamin B receptor	17.58	GeneCards inferred : Publications, Disorders (show sections)
7	PDCD1	programmed cell death 1	17.04	GeneCards inferred : Publications, Disorders (show sections)
8	MECP2	methyl CpG binding protein 2 (Rett syndrome)	16.50	GeneCards inferred : Publications, Disorders (show sections)
9	ADA	adenosine deaminase	15.96	GeneCards inferred : Publications, Disorders (show sections)
10	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	15.42	GeneCards inferred : Publications, Disorders (show sections)
11	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	14.88	GeneCards inferred : Disorders (show sections)
12	CT49	cancer/testis antigen 49 (non-protein coding)	14.34	GeneCards inferred : Publications, Disorders (show sections)
13	POU3F1	POU class 3 homeobox 1	13.80	GeneCards inferred : Publications, Disorders (show sections)
14	CTXN2	cortexin 2	13.26	GeneCards inferred : Disorders (show sections)
15	SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	12.72	GeneCards inferred : Disorders (show sections)
16	TICAM2	toll-like receptor adaptor molecule 2	12.18	GeneCards inferred : Disorders (show sections)
17	MXD4	MAX dimerization protein 4	11.64	GeneCards inferred : Disorders (show sections)
18	PURA	purine-rich element binding protein A	11.10	GeneCards inferred : Disorders (show sections)
19	FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	10.55	GeneCards inferred : Disorders (show sections)
20	CD9	CD9 molecule	10.01	GeneCards inferred : Publications, Disorders (show sections)
21	CD40LG	CD40 ligand	9.47	GeneCards inferred : Publications, Disorders (show sections)
22	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	8.93	GeneCards inferred : Publications, Disorders (show sections)
23	CCDC6	coiled-coil domain containing 6	8.39	GeneCards inferred : Disorders (show sections)
24	GCN1L1	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	7.85	GeneCards inferred : Disorders (show sections)
25	IL2	interleukin 2	7.31	GeneCards inferred : Publications, Disorders (show sections)
26	IFNB1	interferon, beta 1, fibroblast	6.77	GeneCards inferred : Disorders (show sections)
27	NFIC	nuclear factor I/C (CCAAT-binding transcription factor)	6.23	GeneCards inferred : Disorders (show sections)
28	SSBP3	single stranded DNA binding protein 3	5.69	GeneCards inferred : Disorders (show sections)
29	CD4	CD4 molecule	5.15	GeneCards inferred : Disorders (show sections)
30	NFIB	nuclear factor I/B	4.61	GeneCards inferred : Disorders (show sections)
31	MBP	myelin basic protein	4.07	GeneCards inferred : Publications, Disorders (show sections)
32	NFIA	nuclear factor I/A	3.53	GeneCards inferred : Disorders (show sections)
33	TNF	tumor necrosis factor	2.99	GeneCards inferred : Publications, Disorders (show sections)
34	GFAP	glial fibrillary acidic protein	2.16	GeneCards inferred : Publications (show sections)
35	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1.61	GeneCards inferred : Publications (show sections)
36	BAX	BCL2-associated X protein	1.07	GeneCards inferred : Publications (show sections)
37	BCL2	B-cell CLL/lymphoma 2	0.52	GeneCards inferred : Publications (show sections)

Products for genes related to Progressive Multifocal Leukoencephalopathy disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	33	33	35
2	LSBio	-	-	37

Genetic Variations for Progressive Multifocal Leukoencephalopathy

Expression for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Progressive Multifocal Leukoencephalopathy

Search GEO for disease gene expression data for Progressive Multifocal Leukoencephalopathy.

Pathways for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
³⁷NCBI BioSystems Database
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Pathways related to Progressive Multifocal Leukoencephalopathy according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	purine nucleotides degradation II (aerobic)³⁷ Hide members adenosine nucleotides degradation II³⁷	10.2	ADA, PNP

Compounds for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
⁴⁴Novoseek, ²⁴HMDB, ¹¹DrugBank, ⁵⁹Tocris Bioscience, ²⁸IUPHAR, ⁴⁹PharmGKB
See all sources

Compounds related to Progressive Multifocal Leukoencephalopathy according to GeneCards/GeneDecks:

(show all 26)

id	Compound	Score	Top Affiliating Genes
1	deoxyinosine⁴⁴ ²⁴	11.6	PNP, ADA
2	9-(beta-d-arabinofuranosyl)guanine⁴⁴	10.6	ADA, PNP
3	nelarabine⁴⁴ ¹¹	11.5	ADA, PNP
4	cordycepin⁴⁴	10.5	ADA, TAT
5	2,3-dideoxyadenosine⁴⁴	10.5	ADA, PNP
6	pentostatin⁴⁴ ⁵⁹ ²⁸ ¹¹	13.5	ADA, PNP
7	2,5-oligoadenylate⁴⁴	10.4	CT49, TAT, ADA
8	ribavirin⁴⁴ ⁴⁹ ¹¹	12.4	LBR, PNP, ADA
9	tuberculin⁴⁴	10.4	LBR, ADA
10	guanosine⁴⁴ ¹¹ ²⁴	12.3	MECP2, TAT, PNP, ADA
11	deoxyadenosine⁴⁴ ²⁴	11.3	ADA, PNP
12	neopterin⁴⁴	10.3	LBR, CD9, ADA
13	didanosine⁴⁴ ¹¹	11.3	ADA, PNP, CD9, LBR
14	vincristine⁴⁴ ⁴⁹ ¹¹	12.3	ADA, TAT, ITGA4
15	pentoxifylline⁴⁴ ¹¹	11.3	LBR, ITGA4, CD9, TAT
16	rantes⁴⁴	10.3	CD9, ITGA4, LBR
17	zidovudine⁴⁴ ¹¹	11.3	LBR, CD9, TAT, ADA
18	purine⁴⁴ ²⁴	11.2	ADA, PNP, CD9, LBR
19	mdms⁴⁴	10.2	CD9, TAT
20	adenosine²⁸ ¹¹ ²⁴	12.1	PNP, ADA
21	gold⁴⁴	10.0	TAT, CD9, LBR
22	alanine⁴⁴	9.9	CT49, MECP2, CD9, TAT, PNP, ADA
23	cysteine⁴⁴	9.8	CT49, LBR, CD9, TAT, PNP, ADA
24	retinoic acid⁴⁴ ²⁴	10.8	CT49, LBR, ITGA4, CD9, TAT, ADA
25	oligonucleotide⁴⁴	9.8	PURA, CT49, MECP2, CD9, TAT
26	tyrosine⁴⁴	9.2	PDCD1, LBR, ITGA4, CD9, TAT, PNP

GO Terms for genes affiliated with Progressive Multifocal Leukoencephalopathy

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Progressive Multifocal Leukoencephalopathy according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	9.9	ADA, CD9, ITGA4, PDCD1

Biological processes related to Progressive Multifocal Leukoencephalopathy according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	purine-containing compound salvage	GO:043101	10.2	ADA, PNP
2	positive regulation of alpha-beta T cell differentiation	GO:046638	9.9	ADA, PNP

Products for genes affiliated with Progressive Multifocal Leukoencephalopathy

Antibodies
Proteins
Lysates

Antibodies

Sources for Progressive Multifocal Leukoencephalopathy

¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Expression Omnibus DataSets

¹⁶Gene Ontology

¹⁷GeneCards

¹⁸GeneDecks

¹⁹GeneReviews

²⁰GeneTests

²¹Genetics Home Reference

²²GTR

²³HGMD

²⁴HMDB

²⁵ICD10

²⁶ICD10 via Orphanet

²⁷ICD9CM

²⁸IUPHAR

²⁹KEGG

³⁰LifeMap Discovery™

³¹LifeSpan BioSciences, Inc.

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PharmGKB

⁵⁰PubMed

⁵¹QIAGEN

⁵²R&D Systems

⁵³Reactome

⁵⁴SABiosciences

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸Thomson Reuters

⁵⁹Tocris Bioscience

⁶⁰UMLS

⁶¹UMLS via Orphanet

⁶²UniProtKB/Swiss-Prot

⁶³Wikipedia

PML MCID: PRG009 MIFTS: 57	Progressive Multifocal Leukoencephalopathy (PML) malady Infectious diseases, Neuronal diseases categories
37 genes, 12 tissues, 175 related diseases, clinical trials.

Progressive Multifocal Leukoencephalopathy (PML) malady