MCID: PRG090
MIFTS: 26

Progressive Relapsing Multiple Sclerosis

Categories: Neuronal diseases

Aliases & Classifications for Progressive Relapsing Multiple Sclerosis

MalaCards integrated aliases for Progressive Relapsing Multiple Sclerosis:

Name: Progressive Relapsing Multiple Sclerosis 12 14
Multiple Sclerosis, Progressive Relapsing 69
Progressive-Relapsing Ms 12
Prms 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050785
MeSH 41 D020528
SNOMED-CT 64 230374002
UMLS 69 C0393666

Summaries for Progressive Relapsing Multiple Sclerosis

Disease Ontology : 12 A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset.

MalaCards based summary : Progressive Relapsing Multiple Sclerosis, also known as multiple sclerosis, progressive relapsing, is related to encephalitis and japanese encephalitis. An important gene associated with Progressive Relapsing Multiple Sclerosis is FCN1 (Ficolin 1), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Creation of C4 and C2 activators. The drugs Adrenocorticotropic Hormone and beta-endorphin have been mentioned in the context of this disorder.

Related Diseases for Progressive Relapsing Multiple Sclerosis

Diseases related to Progressive Relapsing Multiple Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 encephalitis 10.3
2 japanese encephalitis 10.2
3 tick-borne encephalitis 10.1
4 west nile virus 9.9
5 murray valley encephalitis 9.9
6 vaccinia 9.9
7 multiple sclerosis 9.9
8 3mc syndrome 9.9 MASP1 MASP2
9 hereditary angioedema 9.8 MASP1 MASP2
10 leiomyoma, uterine 9.8
11 osteoporosis 9.8
12 osteoarthritis with mild chondrodysplasia 9.8
13 bone mineral density quantitative trait locus 8 9.8
14 bone mineral density quantitative trait locus 15 9.8
15 dengue virus 9.8
16 osteoarthritis 9.8
17 louping ill 9.8
18 st. louis encephalitis 9.8
19 leiomyoma 9.8
20 rhabdomyosarcoma 9.8
21 mannose-binding lectin deficiency 9.7 FCN1 FCN3 MASP2
22 rheumatic fever 9.5 FCN1 FCN2 FCN3 MASP2
23 reproductive system disease 9.4 PGR PRM2

Graphical network of the top 20 diseases related to Progressive Relapsing Multiple Sclerosis:



Diseases related to Progressive Relapsing Multiple Sclerosis

Symptoms & Phenotypes for Progressive Relapsing Multiple Sclerosis

Drugs & Therapeutics for Progressive Relapsing Multiple Sclerosis

Drugs for Progressive Relapsing Multiple Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adrenocorticotropic Hormone Phase 2
2 beta-endorphin Phase 2
3 Hormone Antagonists Phase 2
4 Hormones Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
6 Melanocyte-Stimulating Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTH in Progressive Forms of MS Recruiting NCT01950234 Phase 2 ACTH;Placebo
2 Autologous Mesenchymal Stem Cell (MSC) Transplantation in MS Completed NCT00813969 Phase 1

Search NIH Clinical Center for Progressive Relapsing Multiple Sclerosis

Genetic Tests for Progressive Relapsing Multiple Sclerosis

Anatomical Context for Progressive Relapsing Multiple Sclerosis

Publications for Progressive Relapsing Multiple Sclerosis

Articles related to Progressive Relapsing Multiple Sclerosis:

# Title Authors Year
1
Clinical characteristics of progressive relapsing multiple sclerosis. ( 15327045 )
2004
2
A cost-utility analysis of mitoxantrone hydrochloride and interferon beta-1b in the treatment of patients with secondary progressive or progressive relapsing multiple sclerosis. ( 12749517 )
2003

Variations for Progressive Relapsing Multiple Sclerosis

Expression for Progressive Relapsing Multiple Sclerosis

Search GEO for disease gene expression data for Progressive Relapsing Multiple Sclerosis.

Pathways for Progressive Relapsing Multiple Sclerosis

GO Terms for Progressive Relapsing Multiple Sclerosis

Cellular components related to Progressive Relapsing Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 8.8 FCN1 FCN2 FCN3

Biological processes related to Progressive Relapsing Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.8 FCN1 FCN2 FCN3 MASP1 MASP2 NOD1
2 proteolysis GO:0006508 9.77 FCN1 FCN2 FCN3 MASP1 MASP2
3 immune system process GO:0002376 9.73 FCN1 FCN2 FCN3 MASP1 MASP2 NOD1
4 defense response to Gram-positive bacterium GO:0050830 9.43 FCN2 NOD1
5 negative regulation of viral entry into host cell GO:0046597 9.4 FCN1 FCN3
6 complement activation GO:0006956 9.35 FCN1 FCN2 FCN3 MASP1 MASP2
7 recognition of apoptotic cell GO:0043654 9.33 FCN1 FCN2 FCN3
8 complement activation, lectin pathway GO:0001867 9.02 FCN1 FCN2 FCN3 MASP1 MASP2

Molecular functions related to Progressive Relapsing Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 ATN1 FCN1 FCN2 FCN3 MASP1 MASP2
2 carbohydrate binding GO:0030246 9.33 FCN1 FCN2 FCN3
3 calcium-dependent protein binding GO:0048306 9.13 FCN2 MASP1 MASP2
4 serine-type endopeptidase activity GO:0004252 9.02 FCN1 FCN2 FCN3 MASP1 MASP2

Sources for Progressive Relapsing Multiple Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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