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PSP
MCID: PRG006
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Progressive Supranuclear Palsy malady |
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Sources: 30NIH Rare Diseases, 23MedlinePlus, 31NINDS, 17Genetics Home Reference, 44Wikipedia, 33OMIM, 22MalaCards See all sources Export this MalaCard |
MedlinePlus: Progressive supranuclear palsy (psp) is a rare brain disease. it affects brain cells that control the movement of your eyes. this leads to serious and permanent problems with balance and the way you walk. it usually occurs in middle-aged or elderly people. symptoms are very different in each person, but may include personality changes, speech, vision and swallowing problems. doctors sometimes confuse psp with parkinson's disease or alzheimer's disease.
psp has no cure and no effective treatments. walking aids, special glasses and certain medicines might help somewhat. although the disease gets worse over time, it isn't fatal on its own. however, psp is dangerous because it increases your risk of pneumonia and choking from swallowing problems and injuries from falling.
nih: national institute of neurological disorders and stroke23
MalaCards: Progressive Supranuclear Palsy, also known as steele-richardson-olszewski syndrome, is related to parkinson's disease and corticobasal degeneration. An important gene associated with Progressive Supranuclear Palsy is MAPT (microtubule-associated protein tau), and among its related pathways are Apoptosis and survival Role of CDK5 in neuronal death and survival and Amine ligand-binding receptors. The compounds carbachol and scopolamine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cerebellum, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland. NIH Rare Diseases: Progressive supranuclear palsy is a movement disorder caused by damage to certain nerve cells in the brain. It affects brain cells that control the movement of the eyes. This leads to serious and permanent problems with balance and the way affected individuals walk. It usually occurs in middle-aged or elderly people. Symptoms are very different in each person, but may include personality changes, speech, vision and swallowing problems. Doctors sometimes confuse progressive supranuclear palsy with Parkinson's disease or Alzheimer's disease. Progressive supranuclear palsy has no cure and no effective treatments. In most cases, the genetic cause of this condition is unknown. Rarely, the disease results from mutations in the MAPT gene. 30 NINDS: Progressive supranuclear palsy (PSP) is a rare brain disorder that causes serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. One of the classic signs of the disease is an inability to aim the eyes properly, which occurs because of lesions in the area of the brain that coordinates eye movements. Some individuals describe this effect as a blurring. Affected individuals31 Genetics Home Reference: Progressive supranuclear palsy is a brain disorder that affects movement, vision, speech, and thinking ability (cognition). The signs and symptoms of this disorder usually become apparent in mid- to late adulthood, most often in a person's 60s. Most people with progressive supranuclear palsy survive 5 to 9 years after the disease first appears, although a few affected individuals have lived for more than a decade.17 Wikipedia: Progressive supranuclear palsy (PSP) (or the Steele-Richardson-Olszewski syndrome, after the Canadian...44 more... OMIM: 601104 |
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 17Genetics Home Reference, 31NINDS, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 27NCIt, 24MeSH See all sources |
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Sources: 33OMIM See all sources |
Clinical features from OMIM: 601104
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for progressive supranuclear palsy Drug clinical trials:Search ClinicalTrials for progressive supranuclear palsy Search NIH Clinical Center for progressive supranuclear palsy Search CenterWatch for progressive supranuclear palsy |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to progressive supranuclear palsy:22Brain, Cortex, Cerebellum, Spinal cord, T cells, B cells, Thalamus, Pons, Adrenal cortex
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to progressive supranuclear palsy:25 (show all 20)
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Sources: 35PubMed See all sources |
Articles related to progressive supranuclear palsy:(show top 50) (show all 143)
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Sources: 1BioGPS See all sources |
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Sources: 10EMD Millipore, 38Reactome, 34PharmGKB, 36QIAGEN, 41Thomson Reuters, 20KEGG, 3Cell Signaling Technology See all sources |
Pathways related to progressive supranuclear palsy according to GeneDecks:(show top 50) (show all 51)
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Sources: 32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience See all sources |
Compounds related to progressive supranuclear palsy according to GeneDecks:(show top 50) (show all 293)
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Sources: 12Gene Ontology See all sources |
Cellular components related to progressive supranuclear palsy according to GeneDecks:
Biological processes related to progressive supranuclear palsy according to GeneDecks:(show all 10)
Molecular functions related to progressive supranuclear palsy according to GeneDecks:
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