PSP
MCID: PRG035
MIFTS: 27

Progressive Supranuclear Palsy Atypical (PSP) malady

Rare diseases, Neuronal diseases, Eye diseases categories
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Summaries for Progressive Supranuclear Palsy Atypical

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MalaCards based summary: Progressive Supranuclear Palsy Atypical, also known as progressive supranuclear palsy, is related to corticobasal degeneration and parkinson's disease, and has symptoms including An important gene associated with Progressive Supranuclear Palsy Atypical is MAPT (microtubule-associated protein tau). Affiliated tissues include eye.

Descriptions from OMIM:46 610898,260540,601104,609454

Aliases & Classifications for Progressive Supranuclear Palsy Atypical

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Sources:
48Orphanet, 46OMIM, 62UMLS, 42NIH Rare Diseases, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Progressive Supranuclear Palsy Atypical, Aliases & Descriptions:

Name: Progressive Supranuclear Palsy Atypical 42 62
Progressive Supranuclear Palsy 48 46 62
Atypical Psp 42 48
Progressive Supranuclear Palsy - Parkinsonism 48
Supranuclear Palsy, Progressive Atypical 46
 
Atypical Progressive Supranuclear Palsy 48
Psp-Parkinsonism 48
Psp-P 48
Psp 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Eye diseases


Characteristics (Orphanet epidemiological data):

48
progressive supranuclear palsy - parkinsonism:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly
atypical psp:
Prevalence: 1-9/100000


External Ids:

MESH via Orphanet35 D013494, C537240
ICD10 via Orphanet26 G23.1
UMLS via Orphanet63 C0038868, C1850077

Related Diseases for Progressive Supranuclear Palsy Atypical

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Diseases related to Progressive Supranuclear Palsy Atypical via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1corticobasal degeneration11.2
2parkinson's disease11.1
3multiple system atrophy11.1
4dementia11.0
5alzheimer's disease10.9
6frontotemporal dementia10.8
7neuronitis10.8
8cerebritis10.8
9pick's disease10.8
10apraxia10.8
11aphasia10.7
12tauopathy10.7
13lateral sclerosis10.6
14striatonigral degeneration10.6
15dystonia10.6
16ophthalmoplegia10.6
17internuclear ophthalmoplegia10.5
18creutzfeldt-jakob disease10.5
19progressive supranuclear palsy - corticobasal syndrome10.5
20progressive supranuclear palsy10.5
21amyotrophic lateral sclerosis10.5
22cerebellar ataxia10.5
23hypertension10.5
24rem sleep behavior disorder10.5
25cervicitis10.5
26ataxia10.5
27cerebral atrophy10.5
28progressive supranuclear palsy - progressive non fluent aphasia10.5
29hydrocephalus10.4
30motor neuron disease10.4
31normal pressure hydrocephalus10.4
32pseudobulbar palsy10.4
33synucleinopathy10.4
34limb dystonia10.4
35primary progressive aphasia10.4
36progressive supranuclear palsy, mapt-related10.4
37dysphagia10.4
38myoclonus10.4
39tremor10.4
40progressive supranuclear palsy - pure akinesia with gait freezing10.4
41argyrophilic grain disease10.4
42b-cell lymphomas10.2
43major depressive disorder10.2
44niemann-pick disease10.2
45wrinkles10.2
46neuroleptic malignant syndrome10.2
47hyperkalemic periodic paralysis10.2
48blepharospasm10.2
49cadasil10.2
50subclavian steal syndrome10.2

Graphical network of the top 20 diseases related to Progressive Supranuclear Palsy Atypical:



Diseases related to progressive supranuclear palsy atypical

Symptoms for Progressive Supranuclear Palsy Atypical

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Symptoms by clinical synopsis from OMIM:

260540

Clinical features from OMIM:

610898,260540,601104,609454

HPO human phenotypes related to Progressive Supranuclear Palsy Atypical:

(show all 8)
id Description Frequency HPO Source Accession
1 ophthalmoparesis HP:0000597
2 dementia HP:0000726
3 parkinsonism HP:0001300
4 tremor HP:0001337
5 morphological abnormality of the pyramidal tract HP:0002062
6 rigidity HP:0002063
7 kyphoscoliosis HP:0002751
8 adult onset HP:0003581

Drugs & Therapeutics for Progressive Supranuclear Palsy Atypical

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Drug clinical trials:

Search ClinicalTrials for Progressive Supranuclear Palsy Atypical

Search NIH Clinical Center for Progressive Supranuclear Palsy Atypical

Genetic Tests for Progressive Supranuclear Palsy Atypical

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Anatomical Context for Progressive Supranuclear Palsy Atypical

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MalaCards organs/tissues related to Progressive Supranuclear Palsy Atypical:

32
Eye

Animal Models for Progressive Supranuclear Palsy Atypical or affiliated genes

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Publications for Progressive Supranuclear Palsy Atypical

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Variations for Progressive Supranuclear Palsy Atypical

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Expression for genes affiliated with Progressive Supranuclear Palsy Atypical

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Expression patterns in normal tissues for genes affiliated with Progressive Supranuclear Palsy Atypical

Search GEO for disease gene expression data for Progressive Supranuclear Palsy Atypical.

Pathways for genes affiliated with Progressive Supranuclear Palsy Atypical

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Compounds for genes affiliated with Progressive Supranuclear Palsy Atypical

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GO Terms for genes affiliated with Progressive Supranuclear Palsy Atypical

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Products for genes affiliated with Progressive Supranuclear Palsy Atypical

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  • Antibodies
  • Proteins
  • Lysates

Sources for Progressive Supranuclear Palsy Atypical

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet