PSP-P
MCID: PRG035
MIFTS: 23

Progressive Supranuclear Palsy Atypical (PSP-P) malady

Neuronal, Eye categories

Summaries for Progressive Supranuclear Palsy Atypical

Sources:
47OMIM, 33MalaCards
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MalaCards: Progressive Supranuclear Palsy Atypical, also known as atypical psp, is related to parkinson's disease and brain disease. An important gene associated with Progressive Supranuclear Palsy Atypical is MAPT (microtubule-associated protein tau). The drugs procyclidine and procyclidine hydrochloride have been mentioned in the context of this disorder.

Description from OMIM:47 260540

Aliases & Classifications for Progressive Supranuclear Palsy Atypical

Sources:
43NIH Rare Diseases, 61UMLS, 49Orphanet, 47OMIM, 26ICD10 via Orphanet, 36MESH via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Eye


Characteristics (Orphanet epidemiological data):

49
progressive supranuclear palsy - parkinsonism:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly
atypical psp:
Prevalence: 1-9/100000


Aliases & Descriptions:

progressive supranuclear palsy atypical 43 61
atypical psp 43 49
progressive supranuclear palsy - parkinsonism 49
supranuclear palsy, progressive atypical 47
atypical progressive supranuclear palsy 49
parkinsonian disorders 61
psp-parkinsonism 49
psp-p 49


External Ids:

OMIM47 260540
ICD10 via Orphanet26 G23.1
MESH via Orphanet36 C537240
UMLS via Orphanet62 C1850077

Related Diseases for Progressive Supranuclear Palsy Atypical

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Progressive Supranuclear Palsy Atypical via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease10.6
2brain disease10.5
3corticobasal degeneration10.5
4progressive supranuclear palsy10.4
5char syndrome10.3
6lateral sclerosis10.3
7aphasia10.3
8apraxia10.3
9williams syndrome10.2
10supranuclear palsy, progressive, 210.2
11focal dystonia10.0
12snca-related parkinson disease10.0
13ataxia10.0
14autonomic dysfunction10.0

Graphical network of diseases related to Progressive Supranuclear Palsy Atypical:



Diseases related to progressive supranuclear palsy atypical

Clinical Features for Progressive Supranuclear Palsy Atypical

Sources:
47OMIM
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Clinical features from OMIM:

260540

Clinical synopsis from OMIM:

260540

Drugs & Therapeutics for Progressive Supranuclear Palsy Atypical

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Progressive Supranuclear Palsy Atypical

Drug clinical trials:

Search ClinicalTrials for Progressive Supranuclear Palsy Atypical

Search NIH Clinical Center for Progressive Supranuclear Palsy Atypical

Search CenterWatch for Progressive Supranuclear Palsy Atypical

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Progressive Supranuclear Palsy Atypical

Anatomical Context for Progressive Supranuclear Palsy Atypical

Animal Models for Progressive Supranuclear Palsy Atypical or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Progressive Supranuclear Palsy Atypical

Sources:
51PubMed
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Articles related to Progressive Supranuclear Palsy Atypical:

idTitleAuthorsYear
1
A case of atypical progressive supranuclear palsy. (24368882)
2014
2
Atypical progressive supranuclear palsy presenting as primary lateral sclerosis. (23570981)
2013
3
"Atypical" atypical parkinsonism: new genetic conditions presenting with features of progressive supranuclear palsy, corticobasal degeneration, or multiple system atrophy-a diagnostic guide. (23720239)
2013
4
Familial aggregation in atypical Parkinson's disease: a case control study in multiple system atrophy and progressive supranuclear palsy. (20625759)
2010
5
Neuropsychological findings in clinically atypical autopsy confirmed corticobasal degeneration and progressive supranuclear palsy. (17977057)
2008
6
Atypical progressive supranuclear palsy with corticospinal tract degeneration. (16691120)
2006
7
Atypical progressive supranuclear palsy underlying progressive apraxia of speech and nonfluent aphasia. (16093229)
2005
8
Glial localization of four-repeat tau in atypical progressive supranuclear palsy. (15068174)
2004
9
Familial atypical progressive supranuclear palsy associated with homozygosity for the delN296 mutation in the tau gene. (11220749)
2001
10
Direct genetic evidence for involvement of tau in progressive supranuclear palsy. European Study Group on Atypical Parkinsonism Consortium. (9781517)
1998

Genetic Variations for Progressive Supranuclear Palsy Atypical

Expression for genes affiliated with Progressive Supranuclear Palsy Atypical

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Progressive Supranuclear Palsy Atypical

Search GEO for disease gene expression data for Progressive Supranuclear Palsy Atypical.

Pathways for genes affiliated with Progressive Supranuclear Palsy Atypical

Compounds for genes affiliated with Progressive Supranuclear Palsy Atypical

GO Terms for genes affiliated with Progressive Supranuclear Palsy Atypical

Products for genes affiliated with Progressive Supranuclear Palsy Atypical

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Progressive Supranuclear Palsy Atypical

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet