MCID: PRG083
MIFTS: 19

Progressive Supranuclear Palsy - Corticobasal Syndrome malady

Neuronal diseases, Eye diseases categories

Summaries for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Progressive Supranuclear Palsy - Corticobasal Syndrome, also known as psp-corticobasal syndrome, is related to progressive supranuclear palsy and blindness. An important gene associated with Progressive Supranuclear Palsy - Corticobasal Syndrome is MAPT (microtubule-associated protein tau), and among its related pathways is Integrated Pancreatic Cancer Pathway. The compounds vinorelbine and docetaxel have been mentioned in the context of this disorder. Affiliated tissues include eye.

Aliases & Classifications for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
Sources:
48Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Eye diseases


Characteristics (Orphanet epidemiological data):

48
progressive supranuclear palsy - corticobasal syndrome:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

progressive supranuclear palsy - corticobasal syndrome 48
psp-corticobasal syndrome 48
psp-cbs 48


External Ids:

ICD10 via Orphanet26 G23.1

Related Diseases for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Progressive Supranuclear Palsy - Corticobasal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1progressive supranuclear palsy30.5MAPT
2blindness10.0VEGFA
3brain ischemia10.0MAPT
4motor neuron disease10.0MAPT
5malaria10.0MAPT
6amyotrophic lateral sclerosis10.0MAPT
7down syndrome10.0MAPT
8dementia10.0MAPT
9vascular dementia10.0MAPT, VEGFA
10malignant glioma10.0VEGFA, MAPT

Graphical network of diseases related to Progressive Supranuclear Palsy - Corticobasal Syndrome:



Diseases related to progressive supranuclear palsy - corticobasal syndrome

Clinical Features for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section

Drugs & Therapeutics for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Progressive Supranuclear Palsy - Corticobasal Syndrome

Drug clinical trials:

Search ClinicalTrials for Progressive Supranuclear Palsy - Corticobasal Syndrome

Search NIH Clinical Center for Progressive Supranuclear Palsy - Corticobasal Syndrome

Search CenterWatch for Progressive Supranuclear Palsy - Corticobasal Syndrome

Genetic Tests for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section

Anatomical Context for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Progressive Supranuclear Palsy - Corticobasal Syndrome:

32
Eye

Animal Models for Progressive Supranuclear Palsy - Corticobasal Syndrome or affiliated genes

About this section

Publications for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section

Genetic Variations for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section

Expression for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

Search GEO for disease gene expression data for Progressive Supranuclear Palsy - Corticobasal Syndrome.

Pathways for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
Sources:
37NCBI BioSystems Database
See all sources

Pathways related to Progressive Supranuclear Palsy - Corticobasal Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MAPT, VEGFA

Compounds for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Progressive Supranuclear Palsy - Corticobasal Syndrome according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1vinorelbine44 1110.4MAPT, VEGFA
2docetaxel44 49 59 1112.4MAPT, VEGFA
3mg 13244 5910.3VEGFA, MAPT
4n acetylcysteine449.3MAPT, VEGFA
5paclitaxel44 49 1111.3MAPT, VEGFA
6doxorubicin44 49 1111.2VEGFA, MAPT
7actinomycin d449.2MAPT, VEGFA
8paraffin449.1MAPT, VEGFA
9cycloheximide449.1MAPT, VEGFA
10genistein44 28 59 2 11 2414.0VEGFA, MAPT
11heparin44 28 11 2411.8MAPT, VEGFA

GO Terms for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section

Products for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Progressive Supranuclear Palsy - Corticobasal Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet