MCID: PRG083
MIFTS: 18

Progressive Supranuclear Palsy - Corticobasal Syndrome malady

Neuronal, Eye categories

Summaries for Progressive Supranuclear Palsy - Corticobasal Syndrome

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33MalaCards
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MalaCards: Progressive Supranuclear Palsy - Corticobasal Syndrome, also known as psp-corticobasal syndrome, is related to progressive supranuclear palsy and n syndrome. An important gene associated with Progressive Supranuclear Palsy - Corticobasal Syndrome is MAPT (microtubule-associated protein tau), and among its related pathways is Integrated Pancreatic Cancer Pathway. The compounds vinorelbine and docetaxel have been mentioned in the context of this disorder. Affiliated tissues include brain.

Aliases & Classifications for Progressive Supranuclear Palsy - Corticobasal Syndrome

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49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Eye


Characteristics (Orphanet epidemiological data):

49
progressive supranuclear palsy - corticobasal syndrome:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

progressive supranuclear palsy - corticobasal syndrome 49
psp-corticobasal syndrome 49
psp-cbs 49


External Ids:

ICD10 via Orphanet26 G23.1

Related Diseases for Progressive Supranuclear Palsy - Corticobasal Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Progressive Supranuclear Palsy - Corticobasal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1progressive supranuclear palsy30.6MAPT
2n syndrome10.4
3blindness10.0VEGFA
4brain ischemia10.0MAPT
5motor neuron disease10.0MAPT
6malaria10.0MAPT
7amyotrophic lateral sclerosis10.0MAPT
8down syndrome10.0MAPT
9dementia10.0MAPT
10vascular dementia10.0MAPT, VEGFA
11malignant glioma10.0VEGFA, MAPT

Graphical network of diseases related to Progressive Supranuclear Palsy - Corticobasal Syndrome:



Diseases related to progressive supranuclear palsy - corticobasal syndrome

Clinical Features for Progressive Supranuclear Palsy - Corticobasal Syndrome

Drugs & Therapeutics for Progressive Supranuclear Palsy - Corticobasal Syndrome

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Progressive Supranuclear Palsy - Corticobasal Syndrome

Search CenterWatch for Progressive Supranuclear Palsy - Corticobasal Syndrome

Genetic Tests for Progressive Supranuclear Palsy - Corticobasal Syndrome

Anatomical Context for Progressive Supranuclear Palsy - Corticobasal Syndrome

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33MalaCards
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MalaCards organs/tissues related to Progressive Supranuclear Palsy - Corticobasal Syndrome:

33
Brain

Animal Models for Progressive Supranuclear Palsy - Corticobasal Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Progressive Supranuclear Palsy - Corticobasal Syndrome

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51PubMed
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Articles related to Progressive Supranuclear Palsy - Corticobasal Syndrome:

idTitleAuthorsYear
1
Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant. (23432126)
2014
2
Diffuse lewy body disease presenting as corticobasal syndrome and progressive supranuclear palsy syndrome. (23400932)
2013
3
Neuroanatomical correlates of the progressive supranuclear palsy corticobasal syndrome hybrid. (22519566)
2012
4
Familial aggregation in Progressive Supranuclear Palsy and Corticobasal Syndrome. (20482608)
2010
5
Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia. (20558417)
2010
6
VEGF haplotypes are associated with increased risk to progressive supranuclear palsy and corticobasal syndrome. (20413880)
2010
7
Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy. (19323870)
2009
8
Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy. (16401739)
2006
9
Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome. (15834857)
2005

Genetic Variations for Progressive Supranuclear Palsy - Corticobasal Syndrome

Expression for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

Search GEO for disease gene expression data for Progressive Supranuclear Palsy - Corticobasal Syndrome.

Pathways for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

Sources:
38NCBI BioSystems Database
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Pathways related to Progressive Supranuclear Palsy - Corticobasal Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MAPT, VEGFA

Compounds for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Progressive Supranuclear Palsy - Corticobasal Syndrome according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1vinorelbine45 1110.4MAPT, VEGFA
2docetaxel45 50 60 1112.4MAPT, VEGFA
3mg 13245 6010.3VEGFA, MAPT
4n acetylcysteine459.3MAPT, VEGFA
5paclitaxel45 50 1111.3MAPT, VEGFA
6doxorubicin45 50 1111.2VEGFA, MAPT
7actinomycin d459.2MAPT, VEGFA
8paraffin459.1MAPT, VEGFA
9cycloheximide459.1MAPT, VEGFA
10genistein45 29 60 2 11 2414.0VEGFA, MAPT
11heparin45 29 11 2411.8MAPT, VEGFA

GO Terms for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

Products for genes affiliated with Progressive Supranuclear Palsy - Corticobasal Syndrome

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Sources for Progressive Supranuclear Palsy - Corticobasal Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet