PTGC
MCID: PRG036
MIFTS: 10

Progressive Transformation of Germinal Centers (PTGC) malady

Summaries for Progressive Transformation of Germinal Centers

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Progressive transformation of germinal centers is a condition in which a lymph node becomes very enlarged (lymphadenopathy).  typically, only one lymph node is affected, though ptgc can involve multiple lymph nodes.  the neck is the most common location of affected lymph nodes, but ptgc may also affect lymph nodes in the groin and armpits.  adults are more frequently affected than children, but children have a higher chance of developing ptgc multiple times (recurrence).  ptgc is not considered a precancerous condition, though it has been associated with hodgkin lymphoma. last updated: 4/24/2013

MalaCards: Progressive Transformation of Germinal Centers, also known as PTGC, is related to follicular lymphoma and young syndrome. An important gene associated with Progressive Transformation of Germinal Centers is PDPK1 (3-phosphoinositide dependent protein kinase-1), and among its related pathways is Disease. Affiliated tissues include lymph node, and related mouse phenotype embryogenesis.

Wikipedia:64 Progressive transformation of germinal centres, abbreviated PTGCs and also progressive transformation of... more...

Aliases & Classifications for Progressive Transformation of Germinal Centers

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

progressive transformation of germinal centers 43
ptgc 43


Related Diseases for Progressive Transformation of Germinal Centers

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Progressive Transformation of Germinal Centers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1follicular lymphoma10.6
2young syndrome10.3

Clinical Features for Progressive Transformation of Germinal Centers

Drugs & Therapeutics for Progressive Transformation of Germinal Centers

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Progressive Transformation of Germinal Centers

Anatomical Context for Progressive Transformation of Germinal Centers

Sources:
33MalaCards
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MalaCards organs/tissues related to Progressive Transformation of Germinal Centers:

33
Lymph node

Animal Models for Progressive Transformation of Germinal Centers or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Progressive Transformation of Germinal Centers:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.1H2AFZ, PDPK1

Publications for Progressive Transformation of Germinal Centers

Genetic Variations for Progressive Transformation of Germinal Centers

Expression for genes affiliated with Progressive Transformation of Germinal Centers

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Progressive Transformation of Germinal Centers

Search GEO for disease gene expression data for Progressive Transformation of Germinal Centers.

Pathways for genes affiliated with Progressive Transformation of Germinal Centers

Sources:
54Reactome
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Pathways related to Progressive Transformation of Germinal Centers according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1H2AFZ, PDPK1

Compounds for genes affiliated with Progressive Transformation of Germinal Centers

GO Terms for genes affiliated with Progressive Transformation of Germinal Centers

Products for genes affiliated with Progressive Transformation of Germinal Centers

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Progressive Transformation of Germinal Centers

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet