PTGC
MCID: PRG036
MIFTS: 14

Progressive Transformation of Germinal Centers (PTGC) malady

Rare diseases category
Download this MalaCard

Summaries for Progressive Transformation of Germinal Centers

About this section
Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
NIH Rare Diseases:43 Progressive transformation of germinal centers is a condition in which a lymph node becomes very enlarged (lymphadenopathy).  typically, only one lymph node is affected, though ptgc can involve multiple lymph nodes.  the neck is the most common location of affected lymph nodes, but ptgc may also affect lymph nodes in the groin and armpits.  adults are more frequently affected than children, but children have a higher chance of developing ptgc multiple times (recurrence).  ptgc is not considered a precancerous condition, though it has been associated with hodgkin lymphoma. last updated: 4/24/2013

MalaCards: Progressive Transformation of Germinal Centers, also known as PTGC, is related to follicular lymphoma and cervicitis. Affiliated tissues include lymph node.

Wikipedia:65 Progressive transformation of germinal centres, abbreviated PTGCs and also progressive transformation of... more...

Aliases & Classifications for Progressive Transformation of Germinal Centers

About this section
Sources:
43NIH Rare Diseases
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

progressive transformation of germinal centers 43
ptgc 43


Related Diseases for Progressive Transformation of Germinal Centers

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Progressive Transformation of Germinal Centers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1follicular lymphoma10.6
2cervicitis10.3
3castleman's disease10.3

Symptoms for Progressive Transformation of Germinal Centers

About this section

Drugs & Therapeutics for Progressive Transformation of Germinal Centers

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Progressive Transformation of Germinal Centers

Search NIH Clinical Center for Progressive Transformation of Germinal Centers

Genetic Tests for Progressive Transformation of Germinal Centers

About this section

Anatomical Context for Progressive Transformation of Germinal Centers

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Progressive Transformation of Germinal Centers:

33
Lymph node

Animal Models for Progressive Transformation of Germinal Centers or affiliated genes

About this section

Publications for Progressive Transformation of Germinal Centers

About this section
Sources:
52PubMed
See all sources

Articles related to Progressive Transformation of Germinal Centers:

(show all 22)
idTitleAuthorsYear
1
Progressive transformation of germinal centers in children and adolescents: an intriguing cause of lymphadenopathy. (22707034)
2013
2
A pediatric translational perspective on the entity "progressive transformation of germinal centers (PTGC)". (22976884)
2013
3
Progressive transformation of germinal centers and Hodgkin lymphoma: more insights but maybe more confusion? (21888616)
2011
4
In situ follicular lymphoma associated with progressive transformation of germinal centers. (19948639)
2011
5
Efficacy and safety of rituximab treatment in patients with progressive transformation of germinal centers after Hodgkin lymphoma in complete remission post-induction chemotherapy and radiotherapy. (21663508)
2011
6
Progressive transformation of germinal centers in a pediatric patient: initial evaluation and follow-up with serial F-18 FDG PET/CT imaging. (21892026)
2011
7
Progressive transformation of germinal centers (PTGC) in the head and neck. (21225766)
2010
8
PET positive progressive transformation of germinal centers masquerading as relapsed Hodgkin lymphoma post-autograft. (16886280)
2006
9
Progressive transformation of germinal centers: an uncommon cause of pediatric cervical lymphadenopathy. (16847193)
2006
10
Progressive transformation of germinal center presenting with histological features of hyaline-vascular type of Castleman's disease. (15865611)
2005
11
Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients. (12754626)
2003
12
Follicular hyperplasia, follicular lysis, and progressive transformation of germinal centers. A sequential spectrum of morphologic evolution in lymphoid hyperplasia. (14502795)
2003
13
Progressive transformation of germinal centers. Report of 2 cases and review of the literature. (12145465)
2002
14
Progressive transformation of germinal centers: review of histopathologic and clinical features. (12242134)
2002
15
Progressive transformation of germinal centers and nodular lymphocyte predominance Hodgkin's disease: a comparative immunohistochemical study. (9888701)
1999
16
Florid progressive transformation of germinal centers. A syndrome affecting young men, without early progression to nodular lymphocyte predominance Hodgkin's disease. (1599017)
1992
17
Progressive transformation of germinal centers: comparison of 23 pediatric patients to the adult population. (1574490)
1992
18
Progressive transformation of germinal centers with and without association to Hodgkin's disease. (2405631)
1990
19
Follicular lymphoma mimicking progressive transformation of germinal centers: immunologic analysis of a case. (3052020)
1988
20
Follicular lymphoma mimicking progressive transformation of germinal centers. (3307374)
1987
21
Differential diagnostic features of nodular L & H Hodgkin's disease, including progressive transformation of germinal centers. (6369997)
1984
22
Clinical implications of progressive transformation of germinal centers. (6496841)
1984

Variations for Progressive Transformation of Germinal Centers

About this section

Expression for genes affiliated with Progressive Transformation of Germinal Centers

About this section
Sources:
15Gene Expression Omnibus DataSets
See all sources

Search GEO for disease gene expression data for Progressive Transformation of Germinal Centers.

Pathways for genes affiliated with Progressive Transformation of Germinal Centers

About this section

Compounds for genes affiliated with Progressive Transformation of Germinal Centers

About this section

GO Terms for genes affiliated with Progressive Transformation of Germinal Centers

About this section

Products for genes affiliated with Progressive Transformation of Germinal Centers

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Progressive Transformation of Germinal Centers

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet