MCID: PRG091
MIFTS: 18

Progressively Deforming Osteogenesis Imperfecta malady

Bone diseases category

Summaries for Progressively Deforming Osteogenesis Imperfecta

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32MalaCards
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MalaCards: Progressively Deforming Osteogenesis Imperfecta, also known as multiple sclerosis, progressive relapsing, is related to osteogenesis imperfecta type iii and osteogenesis imperfecta type i. An important gene associated with Progressively Deforming Osteogenesis Imperfecta is COL1A2 (collagen, type I, alpha 2), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds cyanogen bromide and procollagen have been mentioned in the context of this disorder.

Aliases & Classifications for Progressively Deforming Osteogenesis Imperfecta

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20GeneTests, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

progressively deforming osteogenesis imperfecta 20
multiple sclerosis, progressive relapsing 60


Related Diseases for Progressively Deforming Osteogenesis Imperfecta

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Progressively Deforming Osteogenesis Imperfecta:



Diseases related to progressively deforming osteogenesis imperfecta

Clinical Features for Progressively Deforming Osteogenesis Imperfecta

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Drugs & Therapeutics for Progressively Deforming Osteogenesis Imperfecta

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Progressively Deforming Osteogenesis Imperfecta

Drug clinical trials:

Search ClinicalTrials for Progressively Deforming Osteogenesis Imperfecta

Search NIH Clinical Center for Progressively Deforming Osteogenesis Imperfecta

Search CenterWatch for Progressively Deforming Osteogenesis Imperfecta

Genetic Tests for Progressively Deforming Osteogenesis Imperfecta

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20GeneTests
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Genetic tests related to Progressively Deforming Osteogenesis Imperfecta:

id Genetic test Affiliating Genes
1 Progressively Deforming Osteogenesis Imperfecta20 COL1A2

Anatomical Context for Progressively Deforming Osteogenesis Imperfecta

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Animal Models for Progressively Deforming Osteogenesis Imperfecta or affiliated genes

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Publications for Progressively Deforming Osteogenesis Imperfecta

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Genetic Variations for Progressively Deforming Osteogenesis Imperfecta

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Expression for genes affiliated with Progressively Deforming Osteogenesis Imperfecta

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Progressively Deforming Osteogenesis Imperfecta

Search GEO for disease gene expression data for Progressively Deforming Osteogenesis Imperfecta.

Pathways for genes affiliated with Progressively Deforming Osteogenesis Imperfecta

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53Reactome, 49PharmGKB
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Pathways related to Progressively Deforming Osteogenesis Imperfecta according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CD36, COL1A2
29.3CD36, COL1A2

Compounds for genes affiliated with Progressively Deforming Osteogenesis Imperfecta

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44Novoseek
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Compounds related to Progressively Deforming Osteogenesis Imperfecta according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyanogen bromide449.5CD36, COL1A2
2procollagen449.4CD36, COL1A2
3vitamin d449.3CD36, COL1A2
4glycosaminoglycan449.1CD36, SERPINF1
5matrigel448.8SERPINF1, CD36
6cysteine448.6SERPINF1, CD36, COL1A2
7serine448.4SERPINF1, CD36, COL1A2

GO Terms for genes affiliated with Progressively Deforming Osteogenesis Imperfecta

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16Gene Ontology
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Cellular components related to Progressively Deforming Osteogenesis Imperfecta according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.0SERPINF1, COL1A2

Biological processes related to Progressively Deforming Osteogenesis Imperfecta according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.3CD36, COL1A2

Products for genes affiliated with Progressively Deforming Osteogenesis Imperfecta

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Progressively Deforming Osteogenesis Imperfecta

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet