MCID: PRL010
MIFTS: 38

Prolactin Producing Pituitary Tumor malady

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Prolactin Producing Pituitary Tumor

Aliases & Descriptions for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 12 14
Prolactin-Producing Pituitary Gland Carcinoma 12 69
Prolactin-Producing Pituitary Tumor 52 69
Malignant Prolactin Producing Neoplasm of Pituitary Gland 12
Prolactin Secreting Tumor of Pituitary 12
Malignant Prolactinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5396
NCIt 47 C5962 C7910

Summaries for Prolactin Producing Pituitary Tumor

Disease Ontology : 12 A pituitary carcinoma that is located in the anterior lobe of the pituitary gland that produces prolactin.

MalaCards based summary : Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary gland carcinoma, is related to pituitary tumors and rhinoscleroma. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Neuroscience. The drugs Octreotide and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary and the anterior lobe of the pituitary gl, and related phenotypes are behavior/neurological and integument

Related Diseases for Prolactin Producing Pituitary Tumor

Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 pituitary tumors 10.3
2 rhinoscleroma 10.2 DRD2 PRL
3 pfeiffer rockelein syndrome 10.2 DRD2 PRL
4 ornithosis 10.2 DRD2 PRL
5 stomach diverticulosis 10.2 DRD2 TYRP1
6 cerebral hemisphere lipoma 10.2 PRL SST
7 african histoplasmosis 10.2 PRL SST
8 extragonadal nonseminomatous germ cell tumor 10.2 PRL SST
9 nonparalytic poliomyelitis 10.2 PRL SST
10 pituitary adenoma, acth-secreting 10.2 PRL SST
11 protein s deficiency 10.2 PRL SST
12 bone benign neoplasm 10.2 PRL TP53
13 male reproductive organ benign neoplasm 10.2 PRL TP53
14 central nervous system primitive neuroectodermal neoplasm 10.2 PRL TP53
15 growth retardation hydrocephaly lung hypoplasia 10.2 PRL TP53
16 adult neuronal ceroid lipofuscinosis 10.1 NGF PRL
17 merkel cell carcinoma 10.1 PRL SST
18 nephrogenic adenoma of the urethra 10.1 DRD2 PRL
19 esophagus squamous cell papilloma 10.1 PRL SST
20 gall bladder carcinoma in situ 10.1 NGF NTRK1
21 appendix carcinoid tumor 10.1 NGF NTRK1
22 tabes dorsalis 10.1 SST TP53
23 auriculocondylar syndrome 1 10.1 NGF NTRK1
24 adult brainstem gliosarcoma 10.1 NGF TP53
25 blood group incompatibility 10.1 NGF TP53
26 scleroperikeratitis 10.1 NGF NTRK1
27 gallbladder pleomorphic giant cell adenocarcinoma 10.1 NGF TP53
28 adult epithelioid sarcoma 10.1 NGF TP53
29 cockayne syndrome type i 10.1 CALCA PRL
30 respiratory failure 10.1 NGF NTRK1
31 myoepithelial carcinoma 10.1 NTRK1 SST
32 walker-warburg syndrome 10.1 NGF NTRK1
33 urea cycle disorder 10.1 DRD2 NGF
34 diencephalic neoplasm 10.1 PRL TP53
35 pallister-hall syndrome 10.1 NGF NTRK1
36 mucopolysaccharidosis 10.1 NGF TP53
37 pulmonary neuroendocrine tumor 10.1 DRD2 PRL SST
38 infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations 10.1 DRD2 PRL SST
39 bile acid synthesis defect, congenital, 4 10.1 DRD2 PRL SST
40 cold-induced sweating syndrome 2 10.1 DRD2 PRL SST
41 ovarian clear cell malignant adenofibroma 10.1 NGF SST
42 adamantinous craniopharyngioma 10.1 DRD2 PRL SST
43 rheumatic encephalitis 10.0 PRL SST
44 wells-jankovic syndrome 10.0 CALCA SST
45 chronic eosinophilic pneumonia 10.0 CALCA PRL
46 pemphigus foliaceus 10.0 CALCA SST
47 paranasal sinus cancer, adult 10.0 CALCA SST
48 brain ependymoma 10.0 CALCA SST
49 perineural angioma 10.0 CALCA TP53
50 acute gonococcal cystitis 10.0 CALCA TP53

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to Prolactin Producing Pituitary Tumor

Symptoms & Phenotypes for Prolactin Producing Pituitary Tumor

MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 TP53 TYRP1 DRD2 NGF NTRK1 PRL
2 integument MP:0010771 9.85 DRD2 NGF NTRK1 PRL TP53 TYRP1
3 nervous system MP:0003631 9.8 DRD2 NGF NTRK1 PRL SST TP53
4 neoplasm MP:0002006 9.62 DRD2 PRL TP53 TYRP1
5 no phenotypic analysis MP:0003012 9.55 DRD2 NGF NTRK1 SST TP53
6 normal MP:0002873 9.35 DRD2 NGF NTRK1 SST TP53
7 pigmentation MP:0001186 8.92 DRD2 NTRK1 TP53 TYRP1

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
2
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
3
Cabergoline Approved Phase 3 81409-90-7 54746
4 Gastrointestinal Agents Phase 3,Phase 1
5 Edotreotide Phase 3,Phase 1
6 Radiopharmaceuticals Phase 3,Phase 1
7 Antineoplastic Agents, Hormonal Phase 3,Phase 1
8 Dopamine agonists Phase 3
9 Neurotransmitter Agents Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Dopamine Agents Phase 3
12 Protective Agents Phase 3
13 Autonomic Agents Phase 3
14 Antiparkinson Agents Phase 3
15 Hormones Phase 2,Phase 1
16
Somatostatin Approved Phase 1 38916-34-6, 51110-01-1 53481605
17 pancreatic polypeptide Phase 1
18 Hormone Antagonists Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
20 phenylalanine Nutraceutical Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
2 Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas Recruiting NCT02288962 Phase 3
3 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2
4 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2
5 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
6 Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer Terminated NCT00002947 Phase 1
7 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

Anatomical Context for Prolactin Producing Pituitary Tumor

MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

39
Pituitary

The Foundational Model of Anatomy Ontology organs/tissues related to Prolactin Producing Pituitary Tumor:

18
The Anterior Lobe Of The Pituitary Gl

Publications for Prolactin Producing Pituitary Tumor

Articles related to Prolactin Producing Pituitary Tumor:

id Title Authors Year
1
[Prolactin producing pituitary tumor]. ( 11808216 )
2001
2
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. ( 9808162 )
1998
3
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". ( 9531902 )
1998
4
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. ( 9808163 )
1998
5
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. ( 9500197 )
1998
6
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. ( 7714616 )
1995
7
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. ( 2570719 )
1989
8
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. ( 7098479 )
1982
9
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. ( 985824 )
1976

Variations for Prolactin Producing Pituitary Tumor

Expression for Prolactin Producing Pituitary Tumor

Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for Prolactin Producing Pituitary Tumor

Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.08 NGF PRL TP53
2 12.01 CALCA NGF NTRK1
4
Show member pathways
11.31 NGF NTRK1 TP53
5 10.72 NTRK1 TP53
6
Show member pathways
9.66 NGF NTRK1

GO Terms for Prolactin Producing Pituitary Tumor

Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 CALCA DRD2 NTRK1

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.75 CALCA NGF SST
2 response to heat GO:0009408 9.58 CALCA SST
3 activation of MAPKK activity GO:0000186 9.57 NGF NTRK1
4 activation of protein kinase activity GO:0032147 9.56 CALCA DRD2
5 feeding behavior GO:0007631 9.55 CALCA DRD2
6 response to nicotine GO:0035094 9.54 DRD2 NTRK1
7 pigmentation GO:0043473 9.52 DRD2 TYRP1
8 cellular response to nerve growth factor stimulus GO:1990090 9.51 CALCA NTRK1
9 response to ethanol GO:0045471 9.5 DRD2 NTRK1 PRL
10 regulation of heart rate GO:0002027 9.49 CALCA DRD2
11 negative regulation of blood pressure GO:0045776 9.48 CALCA DRD2
12 response to axon injury GO:0048678 9.46 DRD2 NTRK1
13 negative regulation of cell proliferation GO:0008285 9.46 DRD2 NTRK1 SST TP53
14 positive regulation of Ras protein signal transduction GO:0046579 9.43 NGF NTRK1
15 neurotrophin TRK receptor signaling pathway GO:0048011 9.4 NGF NTRK1
16 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.37 CALCA NTRK1
17 G-protein coupled receptor internalization GO:0002031 9.26 CALCA DRD2
18 phosphatidylinositol-mediated signaling GO:0048015 9.13 NGF NTRK1 TP53
19 response to drug GO:0042493 8.92 DRD2 NTRK1 PRL SST

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.96 TP53 TYRP1
2 hormone activity GO:0005179 8.8 CALCA PRL SST

Sources for Prolactin Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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