MCID: PRL010
MIFTS: 38

Prolactin Producing Pituitary Tumor malady

Endocrine diseases, Cancer diseases categories

Summaries for Prolactin Producing Pituitary Tumor

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary tumor, is related to prolactinoma and goiter. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (prolactin), and among its related pathways are Glucocorticoid receptor regulatory network and Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds sulpiride and flesinoxan have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Prolactin Producing Pituitary Tumor

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

prolactin producing pituitary tumor 8
prolactin-producing pituitary tumor 44 60
malignant prolactin producing neoplasm of pituitary gland 8
prolactin producing pituitary gland carcinoma 60
prolactin secreting tumor of pituitary 8
malignant prolactinoma 8


External Ids:

Disease Ontology8 DOID:5396
NCIt39 C7910

Related Diseases for Prolactin Producing Pituitary Tumor

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1prolactinoma30.8POMC, TRH, AIP, SST, PRL
2goiter30.3TRH
3hyperthyroidism30.3PRL, SST, TRH
4amenorrhea30.3PRL, TRH, POMC
5infertility10.0PRL
6anovulation10.0PRL
7gynecomastia10.0PRL
8zollinger-ellison syndrome10.0SST
9hypogonadotropism10.0PRL
10gastrinoma10.0SST
11hyperthyroxinemia10.0TRH
12euthyroid sick syndrome10.0TRH
13exophthalmos10.0TRH
14hyperinsulinism10.0SST
15duodenal ulcer10.0SST
16addison's disease10.0POMC
17schizoaffective disorder10.0PRL
18prion disease10.0POMC
19hypertension10.0POMC
20adrenocortical carcinoma10.0POMC
21neurogenic diabetes insipidus10.0POMC
22dementia10.0TRH
23peptic ulcer10.0SST
24adrenal adenoma10.0POMC
25hypokalemia10.0POMC
26ganglioneuroma10.0POMC
27cocaine dependence10.0POMC
28arthritis10.0POMC
29acromegaly10.0PRL, SST
30leydig cell tumor10.0POMC
31wermer syndrome10.0SST, PRL
32klinefelter's syndrome10.0TRH, PRL
33paraganglioma10.0SST
34thyroid cancer10.0TRH, SST
35acth-secreting pituitary adenoma10.0PRL, POMC
36schizophrenia10.0PRL, TRH
37acth deficiency10.0POMC, PRL
38anorexia nervosa10.0POMC, PRL
39pituitary cancer10.0POMC, PRL
40chronic fatigue syndrome10.0POMC
41insulin resistance10.0SST
42growth hormone deficiency10.0POMC, PRL
43sheehan syndrome10.0PRL, POMC
44thyrotropin deficiency, isolated10.0POMC, PRL
45carney complex10.0POMC, AIP
46bronchial endocrine tumor10.0SST, POMC
47panhypopituitarism10.0POMC, PRL
48precocious puberty10.0PRL, POMC
49polycystic ovary syndrome10.0PRL, POMC
50cushing's syndrome10.0POMC, SST

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to prolactin producing pituitary tumor

Clinical Features for Prolactin Producing Pituitary Tumor

About this section

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Prolactin Producing Pituitary Tumor

Drug clinical trials:

Search ClinicalTrials for Prolactin Producing Pituitary Tumor

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Search CenterWatch for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

About this section

Anatomical Context for Prolactin Producing Pituitary Tumor

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

32
Pituitary

Animal Models for Prolactin Producing Pituitary Tumor or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4POMC, TRH, AIP, PRL
2MP:00053767.2POMC, TRH, AIP, SST, PRL

Publications for Prolactin Producing Pituitary Tumor

About this section
Sources:
50PubMed
See all sources

Articles related to Prolactin Producing Pituitary Tumor:

(show all 11)
idTitleAuthorsYear
1
Differential gene expression in models of pituitary prolactin-producing tumoral cells. (19407504)
2009
2
Prolactin-producing pituitary adenoma with incomplete neuronal transformation: an intermediate adenoma-neuronal tumor. (15173951)
2004
3
Prolactin producing pituitary tumor]. (11808216)
2001
4
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. (9500197)
1998
5
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. (9808162)
1998
6
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". (9531902)
1998
7
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. (9808163)
1998
8
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. (7714616)
1995
9
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. (2570719)
1989
10
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. (7098479)
1982
11
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. (985824)
1976

Genetic Variations for Prolactin Producing Pituitary Tumor

About this section

Expression for genes affiliated with Prolactin Producing Pituitary Tumor

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Prolactin Producing Pituitary Tumor

Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for genes affiliated with Prolactin Producing Pituitary Tumor

About this section
Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG
See all sources

Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4POMC, PRL
2
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.3POMC, TRH
3
Hide members
8.1PRL, SST, TRH, POMC
4
Hide members
8.1POMC, TRH, SST, PRL

Compounds for genes affiliated with Prolactin Producing Pituitary Tumor

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1sulpiride44 28 1111.8TRH, PRL
2flesinoxan449.8PRL, POMC
3acth 1-24449.8PRL, POMC
4metoclopramide44 1110.8PRL, TRH
5ipsapirone44 2810.8PRL, POMC
611 deoxycortisol449.7PRL, POMC
7mirtazapine49 44 1111.7POMC, PRL
8naltrexone44 49 28 1112.6PRL, POMC
9apomorphine44 28 1111.6PRL, TRH
10quinagolide449.6SST, PRL
1117-hydroxyprogesterone44 2410.6PRL, POMC
125-hydroxytryptophan449.5SST, PRL
13lanreotide44 2810.5PRL, SST
14buserelin44 28 1111.5SST, PRL
15pitressin449.4POMC, SST
16cabergoline28 44 1111.4SST, PRL
17dehydroepiandrosterone sulfate449.4POMC, PRL
18methimazole44 2 1111.3POMC, TRH
19loperamide44 11 2411.3SST, POMC
20fenfluramine28 44 1111.3PRL, TRH, POMC
21triiodothyronine449.3POMC, TRH, PRL
22haloperidol44 28 2 49 1113.3PRL, TRH, POMC
23metyrapone59 44 1111.3SST, POMC
24cocaine44 1110.3PRL, TRH, POMC
25ghrp449.1TRH, SST, PRL
26pyridostigmine44 1110.1PRL, SST, TRH
27domperidone44 28 1111.1TRH, SST, PRL
28levodopa44 1110.1SST, TRH, PRL
29hexarelin44 2810.0POMC, SST, PRL
305-hydroxytryptamine448.9POMC, SST, PRL
31estradiol44 11 2410.9TRH, POMC, PRL
32midazolam44 49 1110.9SST, POMC
33valproate448.9SST, PRL
34epinephrine44 11 2410.9POMC, PRL, SST
35gaba448.8POMC, TRH, SST
36acetylcholine44 49 28 11 2412.7SST, POMC, TRH
37bromocriptine28 44 1110.5SST, PRL, POMC, TRH
38naloxone44 49 28 1111.5PRL, TRH, SST, POMC
39clonidine44 28 1110.5POMC, PRL, SST, TRH
40octreotide44 59 28 1111.5POMC, TRH, PRL, SST
41hydrocortisone44 2 59 1111.5POMC, TRH, PRL, SST
42thyroxine44 249.5POMC, TRH, PRL, SST
43acth448.5POMC, TRH, SST, PRL
44gnrh448.5PRL, TRH, POMC, SST
45norepinephrine44 11 2410.5TRH, POMC, PRL, SST
46dopamine44 28 11 2411.5SST, TRH, PRL, POMC
47testosterone44 59 11 2411.4POMC, SST, PRL, TRH
48dexamethasone44 49 28 1111.4POMC, TRH, SST, PRL
49arginine448.4TRH, SST, PRL, POMC
50glucose448.3PRL, SST, POMC, TRH

GO Terms for genes affiliated with Prolactin Producing Pituitary Tumor

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.6POMC, TRH, PRL
2extracellular regionGO:0055768.1POMC, TRH, SST, PRL

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:0454719.5TRH, PRL
2response to nutrientGO:0075848.9SST, PRL
3cell-cell signalingGO:0072678.4POMC, TRH, SST

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.6POMC, SST, PRL

Products for genes affiliated with Prolactin Producing Pituitary Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prolactin Producing Pituitary Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet