MCID: PRL010
MIFTS: 38

Prolactin Producing Pituitary Tumor malady

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Prolactin Producing Pituitary Tumor

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Aliases & Descriptions for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 11 13
Prolactin-Producing Pituitary Gland Carcinoma 11 68
Prolactin-Producing Pituitary Tumor 50 68
 
Malignant Prolactin Producing Neoplasm of Pituitary Gland 11
Prolactin Secreting Tumor of Pituitary 11
Malignant Prolactinoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:5396
NCIt45 C5962, C7910

Summaries for Prolactin Producing Pituitary Tumor

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Disease Ontology:11 A pituitary carcinoma that is located in the anterior lobe of the pituitary gland that produces prolactin.

MalaCards based summary: Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary gland carcinoma, is related to pituitary tumors and rhinoscleroma. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways are Thyroid cancer and Activation of TRKA receptors. Affiliated tissues include the anterior lobe of the pituitary gl and pituitary, and related mouse phenotypes are neoplasm and pigmentation.

Related Diseases for Prolactin Producing Pituitary Tumor

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Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary tumors10.3
2rhinoscleroma10.2DRD2, PRL
3pfeiffer rockelein syndrome10.2DRD2, PRL
4ornithosis10.2DRD2, PRL
5stomach diverticulosis10.2DRD2, TYRP1
6cerebral hemisphere lipoma10.2PRL, SST
7african histoplasmosis10.2PRL, SST
8extragonadal nonseminomatous germ cell tumor10.2PRL, SST
9nonparalytic poliomyelitis10.2PRL, SST
10pituitary adenoma, acth-secreting10.2PRL, SST
11protein s deficiency10.2PRL, SST
12bone benign neoplasm10.2PRL, TP53
13male reproductive organ benign neoplasm10.2PRL, TP53
14central nervous system primitive neuroectodermal neoplasm10.2PRL, TP53
15growth retardation hydrocephaly lung hypoplasia10.2PRL, TP53
16adult neuronal ceroid lipofuscinosis10.1NGF, PRL
17merkel cell carcinoma10.1PRL, SST
18nephrogenic adenoma of the urethra10.1DRD2, PRL
19esophagus squamous cell papilloma10.1PRL, SST
20gall bladder carcinoma in situ10.1NGF, NTRK1
21appendix carcinoid tumor10.1NGF, NTRK1
22tabes dorsalis10.1SST, TP53
23auriculocondylar syndrome 110.1NGF, NTRK1
24adult brainstem gliosarcoma10.1NGF, TP53
25blood group incompatibility10.1NGF, TP53
26scleroperikeratitis10.1NGF, NTRK1
27gallbladder pleomorphic giant cell adenocarcinoma10.1NGF, TP53
28adult epithelioid sarcoma10.1NGF, TP53
29cockayne syndrome type i10.1CALCA, PRL
30respiratory failure10.1NGF, NTRK1
31myoepithelial carcinoma10.1NTRK1, SST
32walker-warburg syndrome10.1NGF, NTRK1
33urea cycle disorder10.1DRD2, NGF
34diencephalic neoplasm10.1PRL, TP53
35pallister-hall syndrome10.1NGF, NTRK1
36mucopolysaccharidosis10.1NGF, TP53
37pulmonary neuroendocrine tumor10.1DRD2, PRL, SST
38infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations10.1DRD2, PRL, SST
39bile acid synthesis defect, congenital, 410.1DRD2, PRL, SST
40cold-induced sweating syndrome 210.1DRD2, PRL, SST
41ovarian clear cell malignant adenofibroma10.1NGF, SST
42adamantinous craniopharyngioma10.1DRD2, PRL, SST
43rheumatic encephalitis10.0PRL, SST
44wells-jankovic syndrome10.0CALCA, SST
45chronic eosinophilic pneumonia10.0CALCA, PRL
46pemphigus foliaceus10.0CALCA, SST
47paranasal sinus cancer, adult10.0CALCA, SST
48brain ependymoma10.0CALCA, SST
49perineural angioma10.0CALCA, TP53
50acute gonococcal cystitis10.0CALCA, TP53

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to prolactin producing pituitary tumor

Symptoms & Phenotypes for Prolactin Producing Pituitary Tumor

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MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.6DRD2, PRL, TP53, TYRP1
2MP:00011868.7DRD2, NTRK1, TP53, TYRP1
3MP:00030128.7DRD2, NGF, NTRK1, SST, TP53
4MP:00028738.6DRD2, NGF, NTRK1, SST, TP53
5MP:00107718.6DRD2, NGF, NTRK1, PRL, TP53, TYRP1
6MP:00053868.0DRD2, NGF, NTRK1, PRL, SST, TP53
7MP:00036318.0DRD2, NGF, NTRK1, PRL, SST, TP53

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

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Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Octreotideapproved, investigationalPhase 3, Phase 122383150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
2
DopamineapprovedPhase 3383651-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
3
CabergolineapprovedPhase 34681409-90-754746
Synonyms:
(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
(8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-prop-2-en-1-ylergoline-8-carboxamide
1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
81409-90-7
85329-89-1 (diphosphate)
AC-14150
AC1L1HO0
AC1Q5OQ0
BIDD:GT0775
BRD-K86882815-001-01-6
BRN 6020775
C08187
C26H37N5O2
CG-101
CHEBI:3286
 
CHEMBL1201087
CID54746
Cabaser
Cabaser (TN)
Cabaseril
Cabergolina
Cabergolina [Spanish]
Cabergoline
Cabergoline (JAN/USAN/INN)
Cabergoline [USAN:BAN:INN]
Cabergolinum
Cabergolinum [Latin]
D00987
DB00248
Dostinex
Dostinex (TN)
FCE-21336
FT-0081285
Galastop
HMS2090A09
LS-64370
MolPort-003-845-557
Sogilen
UNII-LL60K9J05T
cabergoline
4Antineoplastic Agents, HormonalPhase 3, Phase 15592
5RadiopharmaceuticalsPhase 3, Phase 1514
6EdotreotidePhase 3, Phase 127
7Gastrointestinal AgentsPhase 3, Phase 18402
8Neurotransmitter AgentsPhase 318340
9Peripheral Nervous System AgentsPhase 323689
10Protective AgentsPhase 37443
11Dopamine AgentsPhase 33836
12Dopamine agonistsPhase 3632
13Antiparkinson AgentsPhase 31574
14Autonomic AgentsPhase 310150
15HormonesPhase 2, Phase 114415
16
SomatostatinapprovedPhase 123738916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
17pancreatic polypeptidePhase 120
18Hormone AntagonistsPhase 113180
19Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 113168
20phenylalanineNutraceuticalPhase 1174

Interventional clinical trials:

idNameStatusNCT IDPhase
1Ga-68-DOTATOC -PET in the Management of Pituitary TumoursRecruitingNCT02419664Phase 3
2Dopamine Agonist Treatment of Non-functioning Pituitary AdenomasRecruitingNCT02288962Phase 3
3Temozolomide in Treating Patients With Invasive Pituitary TumorsWithdrawnNCT00601289Phase 2
4Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation TherapyWithdrawnNCT00003514Phase 2
5Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent CancerCompletedNCT00006368Phase 1
6Indium In 111 Pentetreotide in Treating Patients With Refractory CancerTerminatedNCT00002947Phase 1
7Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain DisordersCompletedNCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

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Anatomical Context for Prolactin Producing Pituitary Tumor

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MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

36
Pituitary

FMA organs/tissues related to Prolactin Producing Pituitary Tumor:

17
The anterior lobe of the pituitary gl

Publications for Prolactin Producing Pituitary Tumor

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Articles related to Prolactin Producing Pituitary Tumor:

idTitleAuthorsYear
1
Prolactin producing pituitary tumor]. (11808216)
2001
2
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. (9808162)
1998
3
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". (9531902)
1998
4
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. (9808163)
1998
5
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. (9500197)
1998
6
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. (7714616)
1995
7
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. (2570719)
1989
8
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. (7098479)
1982
9
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. (985824)
1976

Variations for Prolactin Producing Pituitary Tumor

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Expression for genes affiliated with Prolactin Producing Pituitary Tumor

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Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for genes affiliated with Prolactin Producing Pituitary Tumor

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Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5NTRK1, TP53
2
Show member pathways
9.4NGF, NTRK1
49.0NGF, PRL, TP53
5
Show member pathways
8.9NGF, NTRK1, TP53
68.6CALCA, NGF, NTRK1

GO Terms for genes affiliated with Prolactin Producing Pituitary Tumor

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Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304248.8CALCA, DRD2, NTRK1

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1pigmentationGO:004347310.4DRD2, TYRP1
2response to axon injuryGO:004867810.3DRD2, NTRK1
3activation of MAPKK activityGO:000018610.1NGF, NTRK1
4neurotrophin TRK receptor signaling pathwayGO:004801110.1NGF, NTRK1
5positive regulation of Ras protein signal transductionGO:004657910.1NGF, NTRK1
6activation of protein kinase activityGO:003214710.0CALCA, DRD2
7feeding behaviorGO:000763110.0CALCA, DRD2
8G-protein coupled receptor internalizationGO:000203110.0CALCA, DRD2
9negative regulation of blood pressureGO:004577610.0CALCA, DRD2
10cellular response to nerve growth factor stimulusGO:19900909.9CALCA, NTRK1
11detection of temperature stimulus involved in sensory perception of painGO:00509659.9CALCA, NTRK1
12regulation of heart rateGO:00020279.9CALCA, DRD2
13response to ethanolGO:00454719.8DRD2, NTRK1, PRL
14response to nicotineGO:00350949.6DRD2, NTRK1
15response to heatGO:00094089.6CALCA, SST
16phosphatidylinositol-mediated signalingGO:00480159.5NGF, NTRK1, TP53
17response to drugGO:00424939.3DRD2, NTRK1, PRL, SST
18negative regulation of cell proliferationGO:00082859.2DRD2, NTRK1, SST, TP53
19cell-cell signalingGO:00072679.2CALCA, NGF, SST

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:000550710.1TP53, TYRP1
2hormone activityGO:00051798.8CALCA, PRL, SST

Sources for Prolactin Producing Pituitary Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet