Prolactin Producing Pituitary Tumor malady

MalaCards: Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary tumor, is related to thyroiditis and pituitary tumor. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (prolactin), and among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Development Leptin signaling via JAK/STAT and MAPK cascades. The drugs prednisone and prednisolone tebutate and the compounds quinagolide and 5-hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Descriptions:

prolactin producing pituitary tumor 6 8 prolactin-producing pituitary tumor 32 43 malignant prolactin producing neoplasm of pituitary gland 6 prolactin producing pituitary gland carcinoma 43

prolactin secreting tumor of pituitary 6 malignant prolactinoma 6 malignant neoplasms 43 neoplasms 43

Diseases related to prolactin producing pituitary tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1015)

id	Related Disease	Score	Top Affiliating Genes
1	thyroiditis	30.7	SST, PRL, POMC, TRH, AIP
2	pituitary tumor	30.0	PRL, TRH, AIP, POMC, SST
3	neuroendocrine tumor	27.6	POMC, SST
4	prolactinoma	27.4	PRL, TRH, SST, POMC, AIP
5	thyroid cancer	27.4	SST, TRH, AIP, POMC
6	adenoma	26.8	SST, TRH, POMC, PRL, AIP
7	letterer-siwe disease	26.6	PRL, SST, TRH
8	craniopharyngioma	26.2	TRH, POMC, PRL
9	zollinger-ellison syndrome	25.6	SST, POMC
10	gastrinoma	25.5	POMC, SST
11	multiple endocrine neoplasia	25.5	POMC, PRL, SST, AIP
12	thyroid carcinoma	25.3	PRL, POMC, TRH, SST
13	paraganglioma	25.3	POMC, SST
14	hormone producing pituitary cancer	24.8	SST, AIP
15	leydig cell tumor	24.2	PRL, POMC
16	familial medullary thyroid carcinoma	24.2	SST, POMC
17	pituitary adenoma	24.1	AIP, POMC, PRL, SST, TRH
18	myxoma	24.1	POMC, PRL
19	histiocytosis	23.9	SST, PRL, TRH
20	carney complex	23.7	PRL, POMC, AIP
21	polycystic ovary syndrome	23.6	PRL, SST, POMC
22	pheochromocytoma	23.5	PRL, POMC, SST
23	alcoholism	23.4	TRH, POMC
24	acromegaly	22.0	TRH, SST, PRL, AIP, POMC
25	somatotrophinoma	13.0	PRL, AIP
26	focal epilepsy	13.0	SST, PRL
27	wermer syndrome	13.0	SST, PRL
28	cystinosis	12.9	PRL, SST
29	fibrous dysplasia	12.9	SST, PRL
30	generalized resistance to thyroid hormone	12.9	TRH, PRL
31	pseudohypoparathyroidism type ia	12.9	PRL, TRH
32	hyperthyroxinemia	12.9	PRL, TRH
33	myelomeningocele	12.9	PRL, TRH
34	spinocerebellar degeneration	12.9	TRH, PRL
35	borderline personality disorder	12.9	TRH, PRL
36	anovulation	12.9	PRL, TRH
37	dyspepsia	12.9	PRL, SST
38	pseudohypoparathyroidism	12.9	PRL, TRH
39	hypogonadotropism	12.9	PRL, SST
40	delayed puberty	12.8	TRH, PRL
41	schizoaffective disorder	12.8	PRL, SST
42	duodenal ulcer	12.7	SST, PRL
43	lymphocytic hypophysitis	12.7	PRL, POMC
44	sheehan syndrome	12.7	PRL, POMC
45	petrositis	12.7	POMC, PRL
46	thyrotropin deficiency, isolated	12.7	PRL, POMC
47	neurogenic diabetes insipidus	12.7	POMC, PRL
48	thyroid hormone resistance syndrome	12.7	POMC, PRL
49	seasonal affective disorder	12.7	PRL, POMC
50	combined pituitary hormone deficiency	12.7	POMC, PRL

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to prolactin producing pituitary tumor:

²²

MGI Mouse Phenotypes related to prolactin producing pituitary tumor:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	8.1	AIP, TRH, PRL, POMC
2	homeostasis/metabolism phenotype	MP:0005376	7.2	AIP, TRH, SST, PRL, POMC

Articles related to prolactin producing pituitary tumor:

id	Title	Authors	Year	Affiliating Genes
1	Prolactin producing pituitary tumor (11808216)	Miyachi Y.... Shimojo M.	2001	PRL
2	Prolactin producing pituitary tumors in postmenopausal patients--'infrequent or infrequently recognized'. (9531902)	Shringi M.S.... Gogate J.	1998	PRL
3	Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. (7714616)	Kovacs K.... Becker W.	1995	PRL

Genes related to prolactin producing pituitary tumor according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PRL	prolactin	11.1	Publications
2	AIP	aryl hydrocarbon receptor interacting protein	11.0
3	TRH	thyrotropin-releasing hormone	11.0
4	POMC	proopiomelanocortin	11.0
5	SST	somatostatin	11.0

Pathways related to prolactin producing pituitary tumor according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Development_Leptin signaling via JAK/STAT and MAPK cascades41	9.0	TRH, POMC
2	Development Leptin signaling via JAK/STAT and MAPK cascades10	8.7	TRH, POMC

Compounds related to prolactin producing pituitary tumor according to GeneDecks:

(show top 50)    (show all 63)

id	Compound	Score	Top Affiliating Genes
1	quinagolide32	9.9	SST, PRL
2	5-hydroxytryptophan32	9.8	SST, PRL
3	lanreotide32	9.8	PRL, SST
4	buserelin32 9 9	11.8	PRL, SST
5	sulpiride32 9 9	11.7	PRL, TRH
6	cabergoline32 9 9	11.7	SST, PRL
7	metoclopramide32 9 9	11.7	TRH, PRL
8	flesinoxan32	9.6	PRL, POMC
9	acth 1-2432	9.6	PRL, POMC
10	ipsapirone32	9.6	PRL, POMC
11	11 deoxycortisol32	9.6	PRL, POMC
12	pitressin32	9.5	SST, POMC
13	mirtazapine32 34 9 9	12.5	POMC, PRL
14	apomorphine32 9 9	11.5	TRH, PRL
15	gnrh32	9.5	POMC, TRH
16	naltrexone32 34 9 9	12.4	POMC, PRL
17	loperamide32 9 18 9	12.4	POMC, SST
18	metyrapone32 42 9 9	12.4	POMC, SST
19	17-hydroxyprogesterone32 18	10.4	POMC, PRL
20	ghrp32	9.3	PRL, SST, TRH
21	pyridostigmine32 9 9	11.3	TRH, SST, PRL
22	domperidone32 9 9	11.3	TRH, SST, PRL
23	levodopa32 9 9	11.3	TRH, SST, PRL
24	ketoconazole32 42 9 18 9	13.1	SST, POMC
25	hexarelin32	9.1	SST, PRL, POMC
26	methimazole32 9 9	11.1	POMC, TRH
27	5-hydroxytryptamine32	9.0	POMC, PRL, SST
28	midazolam32 9 9	11.0	SST, POMC
29	fenfluramine32 9 9	11.0	POMC, PRL, TRH
30	triiodothyronine32	9.0	POMC, PRL, TRH
31	haloperidol32 34 9 9	12.0	TRH, PRL, POMC
32	cocaine32 9 9	11.0	POMC, PRL, TRH
33	epinephrine32 9 18 9	11.9	SST, PRL, POMC
34	carbamazepine32 34 9 9	11.9	PRL, POMC
35	gaba32 42	9.8	TRH, SST, POMC
36	acetylcholine32 9 18 9	11.7	TRH, SST, POMC
37	estradiol32 9 18 9	11.6	POMC, PRL, TRH
38	bromocriptine32 9 9	10.5	TRH, POMC, PRL, SST
39	naloxone32 34 9 9	11.5	POMC, PRL, SST, TRH
40	clonidine32 9 9	10.5	POMC, PRL, SST, TRH
41	octreotide32 42 9 9	11.5	TRH, SST, PRL, POMC
42	hydrocortisone32 9 9	10.5	POMC, PRL, SST, TRH
43	thyroxine32 18	9.5	TRH, SST, PRL, POMC
44	acth32	8.5	POMC, PRL, SST, TRH
45	norepinephrine32 9 18 9	11.5	TRH, SST, PRL, POMC
46	dopamine32 9 18 9	11.5	POMC, PRL, SST, TRH
47	testosterone32 9 18 9	11.4	POMC, PRL, SST, TRH
48	dexamethasone32 42 34 9 9	12.4	TRH, SST, PRL, POMC
49	arginine32	8.4	POMC, PRL, SST, TRH
50	glucose32	8.3	TRH, SST, PRL, POMC

Cellular components related to prolactin producing pituitary tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	9.0	TRH, POMC
2	extracellular region	GO:005576	7.8	TRH, SST, PRL, POMC

Biological processes related to prolactin producing pituitary tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:007267	8.5	TRH, SST, POMC

Molecular functions related to prolactin producing pituitary tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	8.7	SST, PRL, POMC