MCID: PRL010
MIFTS: 36

Prolactin Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Prolactin Producing Pituitary Tumor

MalaCards integrated aliases for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 12 14
Prolactin-Producing Pituitary Gland Carcinoma 12 69
Prolactin-Producing Pituitary Tumor 52 69
Malignant Prolactin Producing Neoplasm of Pituitary Gland 12
Prolactin Secreting Tumor of Pituitary 12
Malignant Prolactinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5396
NCIt 47 C5962 C7910

Summaries for Prolactin Producing Pituitary Tumor

Disease Ontology : 12 A pituitary carcinoma that is located in the anterior lobe of the pituitary gland that produces prolactin.

MalaCards based summary : Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary gland carcinoma, is related to rhinoscleroma and ornithosis. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways/superpathways are Neuroscience and Circadian rythm related genes. The drugs Octreotide and Antineoplastic Agents, Hormonal have been mentioned in the context of this disorder. Affiliated tissues include pituitary and brain, and related phenotypes are behavior/neurological and integument

Related Diseases for Prolactin Producing Pituitary Tumor

Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 rhinoscleroma 10.6 DRD2 PRL
2 ornithosis 10.5 DRD2 PRL
3 peroxisomal biogenesis disorders 10.5 DRD2 PRL
4 malignant breast melanoma 10.5 DRD2 TYRP1
5 african histoplasmosis 10.5 PRL SST
6 combined t cell and b cell immunodeficiency 10.5 PRL SST
7 lymphoepithelioma-like carcinoma 10.5 PRL SST
8 actinobacillosis 10.4 PRL SST
9 protein s deficiency 10.4 PRL SST
10 adenosine monophosphate deaminase 1 deficiency 10.4 NGF PRL
11 pituitary adenoma, prolactin-secreting 10.4 PRL SST
12 bladder hepatoid adenocarcinoma 10.4 DRD2 PRL
13 trabecular follicular adenocarcinoma 10.4 PRL SST
14 bronchiectasis 10.4 PRL SST
15 neuropathy, hereditary sensory and autonomic, type v 10.4 NGF NTRK1
16 pharynx carcinoma in situ 10.3 NGF NTRK1
17 cecum adenoma 10.3 NGF NTRK1
18 cardiovascular organ benign neoplasm 10.3 PRL SST
19 acute myocarditis 10.3 PRL SST
20 immune system organ benign neoplasm 10.3 PRL TP53
21 group b strep disease in newborns 10.3 PRL TP53
22 scleroperikeratitis 10.3 NGF NTRK1
23 acute female pelvic peritonitis 10.3 DRD2 PRL
24 heart lymphoma 10.3 NGF SST
25 pituitary tumors 10.3
26 psychogenic movement 10.3 PRL SST
27 diencephalic neoplasm 10.2 PRL TP53
28 respiratory failure 10.2 NGF NTRK1
29 adrenal cortex disease 10.2 PRL SST
30 epidermolysis bullosa simplex superficialis 10.2 NGF NTRK1
31 uterine ligament clear cell adenocarcinoma 10.2 PRL SST
32 suppurative periapical periodontitis 10.2 DRD2 NGF
33 greig cephalopolysyndactyly syndrome 10.2 NGF NTRK1
34 rh isoimmunization 10.2 NGF TP53
35 aggressive systemic mastocytosis 10.2 NGF TP53
36 olfactory neural tumor 10.2 NGF TP53
37 paraganglioma 10.1 NGF SST
38 migraine with aura 10.1 SST TP53
39 strabismus 10.1 DRD2 PRL SST
40 cold-induced sweating syndrome 2 10.1 DRD2 PRL SST
41 alpha-methylacyl-coa racemase deficiency 10.1 DRD2 PRL SST
42 pituitary adenoma, acth-secreting 10.1 DRD2 PRL SST
43 fallopian tube leiomyoma 10.1 CALCA PRL
44 febrile seizures, familial, 3b 10.0 NGF NTRK1
45 chronic dacryoadenitis 10.0 CALCA PRL
46 colon mucinous adenocarcinoma 10.0 DRD2 PRL
47 wegmann jones smith syndrome 10.0 CALCA SST
48 malignant visceral pleura tumor 10.0 CALCA NGF
49 pemphigus foliaceus 10.0 CALCA SST
50 pandas 10.0 CALCA SST

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to Prolactin Producing Pituitary Tumor

Symptoms & Phenotypes for Prolactin Producing Pituitary Tumor

MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 DRD2 NGF NTRK1 PRL SST TP53
2 integument MP:0010771 9.85 DRD2 NGF NTRK1 PRL TP53 TYRP1
3 nervous system MP:0003631 9.8 SST TP53 TYRP1 DRD2 NGF NTRK1
4 neoplasm MP:0002006 9.62 DRD2 PRL TP53 TYRP1
5 no phenotypic analysis MP:0003012 9.55 DRD2 NGF NTRK1 SST TP53
6 normal MP:0002873 9.35 DRD2 NGF NTRK1 SST TP53
7 pigmentation MP:0001186 8.92 DRD2 NTRK1 TP53 TYRP1

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
2 Antineoplastic Agents, Hormonal Phase 3,Phase 1
3 Edotreotide Phase 3,Phase 1
4 Gastrointestinal Agents Phase 3,Phase 1
5 Radiopharmaceuticals Phase 3,Phase 1
6 Hormones Phase 2,Phase 1
7
Somatostatin Approved Phase 1 38916-34-6, 51110-01-1 53481605
8 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
9 Hormone Antagonists Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
11 phenylalanine Nutraceutical Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
2 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
3 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
4 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
5 Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer Terminated NCT00002947 Phase 1
6 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

Anatomical Context for Prolactin Producing Pituitary Tumor

MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

39
Pituitary, Brain

Publications for Prolactin Producing Pituitary Tumor

Articles related to Prolactin Producing Pituitary Tumor:

id Title Authors Year
1
[Prolactin producing pituitary tumor]. ( 11808216 )
2001
2
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. ( 9500197 )
1998
3
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. ( 9808163 )
1998
4
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". ( 9531902 )
1998
5
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. ( 9808162 )
1998
6
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. ( 7714616 )
1995
7
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. ( 2570719 )
1989
8
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. ( 7098479 )
1982
9
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. ( 985824 )
1976

Variations for Prolactin Producing Pituitary Tumor

Expression for Prolactin Producing Pituitary Tumor

Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for Prolactin Producing Pituitary Tumor

Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.94 CALCA NGF NTRK1
3
Show member pathways
11.31 NGF NTRK1 TP53
4
Show member pathways
11.11 NGF NTRK1
5
Show member pathways
9.66 NGF NTRK1

GO Terms for Prolactin Producing Pituitary Tumor

Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 CALCA DRD2 NTRK1

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.74 DRD2 NTRK1 SST
2 cell-cell signaling GO:0007267 9.71 CALCA NGF SST
3 response to heat GO:0009408 9.56 CALCA SST
4 activation of MAPKK activity GO:0000186 9.55 NGF NTRK1
5 feeding behavior GO:0007631 9.52 CALCA DRD2
6 response to nicotine GO:0035094 9.51 DRD2 NTRK1
7 pigmentation GO:0043473 9.49 DRD2 TYRP1
8 cellular response to nerve growth factor stimulus GO:1990090 9.48 CALCA NTRK1
9 regulation of heart rate GO:0002027 9.46 CALCA DRD2
10 negative regulation of cell proliferation GO:0008285 9.46 DRD2 NTRK1 SST TP53
11 negative regulation of blood pressure GO:0045776 9.43 CALCA DRD2
12 response to axon injury GO:0048678 9.4 DRD2 NTRK1
13 positive regulation of Ras protein signal transduction GO:0046579 9.37 NGF NTRK1
14 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.32 CALCA NTRK1
15 neurotrophin TRK receptor signaling pathway GO:0048011 9.26 NGF NTRK1
16 G-protein coupled receptor internalization GO:0002031 8.96 CALCA DRD2
17 phosphatidylinositol-mediated signaling GO:0048015 8.8 NGF NTRK1 TP53

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.96 TP53 TYRP1
2 hormone activity GO:0005179 8.8 CALCA PRL SST

Sources for Prolactin Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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