MCID: PRL010
MIFTS: 41

Prolactin Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Prolactin Producing Pituitary Tumor

MalaCards integrated aliases for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 12 14
Prolactin-Producing Pituitary Gland Carcinoma 12 69
Prolactin-Producing Pituitary Tumor 51 69
Malignant Prolactin Producing Neoplasm of Pituitary Gland 12
Prolactin Secreting Tumor of Pituitary 12
Malignant Prolactinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5396
NCIt 46 C5962 C7910

Summaries for Prolactin Producing Pituitary Tumor

Disease Ontology : 12 A pituitary carcinoma that is located in the anterior lobe of the pituitary gland that produces prolactin.

MalaCards based summary : Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary gland carcinoma, is related to pituitary tumors and galactorrhea. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Neuroscience. The drugs Hormones and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include the anterior lobe of the pituitary gl, pituitary and brain, and related phenotypes are behavior/neurological and integument

Related Diseases for Prolactin Producing Pituitary Tumor

Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 30.7 PRL SST
2 galactorrhea 30.4 DRD2 PRL
3 pituitary adenoma, prolactin-secreting 30.3 DRD2 PRL SST
4 schizophreniform disorder 10.4 DRD2 PRL
5 social phobia 10.4 DRD2 PRL
6 peripartum cardiomyopathy 10.3 DRD2 PRL
7 amelanotic melanoma 10.3 DRD2 TYRP1
8 pituitary infarct 10.3 PRL SST
9 tsh producing pituitary tumor 10.3 PRL SST
10 chiasmal syndrome 10.3 PRL SST
11 pituitary adenoma 1, multiple types 10.3 PRL SST
12 nelson syndrome 10.3 PRL SST
13 hyperpituitarism 10.3 PRL SST
14 adenomyosis 10.3 NGF PRL
15 migraine without aura 10.3 DRD2 PRL
16 growth hormone secreting pituitary adenoma 10.3 PRL SST
17 cocaine abuse 10.2 DRD2 PRL
18 adrenal cortex disease 10.2 PRL SST
19 adrenal gland disease 10.2 PRL SST
20 neuropathy, hereditary sensory and autonomic, type v 10.2 NGF NTRK1
21 askin's tumor 10.2 NGF NTRK1
22 pituitary-dependent cushing's disease 10.2 PRL SST
23 endocrine organ benign neoplasm 10.2 PRL SST
24 conjunctival nevus 10.2 NGF NTRK1
25 central nervous system organ benign neoplasm 10.2 PRL TP53
26 sweat gland disease 10.2 NGF NTRK1
27 granulosa cell tumor of the ovary 10.2 PRL TP53
28 cortical thymoma 10.1 NGF SST
29 chromophobe adenoma 10.1 PRL TP53
30 anhidrosis 10.1 NGF NTRK1
31 mccune-albright syndrome 10.1 PRL SST
32 opiate dependence 10.1 DRD2 NGF
33 adrenal gland hyperfunction 10.1 PRL SST
34 ocular cicatricial pemphigoid 10.1 NGF NTRK1
35 cerebral neuroblastoma 10.1 NGF TP53
36 ependymoblastoma 10.1 NGF TP53
37 cerebral cavernous malformations 2 10.1 NGF NTRK1
38 pituitary gland disease 10.1 PRL SST
39 phaeochromocytoma 10.0 NGF SST
40 meningeal melanomatosis 10.0 NGF TP53
41 hereditary sensory neuropathy 10.0 NGF NTRK1
42 functioning pituitary adenoma 10.0 DRD2 PRL SST
43 ovarian cystic teratoma 10.0 CALCA PRL
44 hyperprolactinemia 10.0 DRD2 PRL SST
45 postpartum depression 10.0 CALCA PRL
46 substance abuse 10.0 DRD2 PRL
47 wdha syndrome 9.9 CALCA SST
48 algoneurodystrophy 9.9 CALCA NGF
49 pancreatic somatostatinoma 9.9 CALCA SST
50 pancreatic islet cell tumors 9.9 CALCA SST

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to Prolactin Producing Pituitary Tumor

Symptoms & Phenotypes for Prolactin Producing Pituitary Tumor

MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 PRL SST TP53 DRD2 TYRP1 NGF
2 integument MP:0010771 9.85 PRL TP53 DRD2 TYRP1 NGF NTRK1
3 nervous system MP:0003631 9.8 PRL SST TP53 DRD2 TYRP1 NGF
4 neoplasm MP:0002006 9.62 PRL TP53 DRD2 TYRP1
5 no phenotypic analysis MP:0003012 9.55 SST TP53 DRD2 NGF NTRK1
6 normal MP:0002873 9.35 NTRK1 SST TP53 DRD2 NGF
7 pigmentation MP:0001186 8.92 TP53 DRD2 TYRP1 NTRK1

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 2,Phase 1
2
Octreotide Approved, Investigational Phase 1 83150-76-9 6400441 383414
3
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
4 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
5 Gastrointestinal Agents Phase 1
6 Edotreotide Phase 1
7 Antineoplastic Agents, Hormonal Phase 1
8 Radiopharmaceuticals Phase 1
9 Hormone Antagonists Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
11 phenylalanine Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
2 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer Terminated NCT00002947 Phase 1
5 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

Anatomical Context for Prolactin Producing Pituitary Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Prolactin Producing Pituitary Tumor:

18
The Anterior Lobe Of The Pituitary Gl

MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

38
Pituitary, Brain

Publications for Prolactin Producing Pituitary Tumor

Articles related to Prolactin Producing Pituitary Tumor:

# Title Authors Year
1
[Prolactin producing pituitary tumor]. ( 11808216 )
2001
2
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. ( 9808163 )
1998
3
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. ( 9500197 )
1998
4
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. ( 9808162 )
1998
5
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". ( 9531902 )
1998
6
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. ( 7714616 )
1995
7
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. ( 2570719 )
1989
8
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. ( 7098479 )
1982
9
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. ( 985824 )
1976

Variations for Prolactin Producing Pituitary Tumor

Expression for Prolactin Producing Pituitary Tumor

Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for Prolactin Producing Pituitary Tumor

Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.38 NGF NTRK1 PRL TP53
2 12.03 CALCA NGF NTRK1
4
Show member pathways
11.31 NGF NTRK1 TP53
5
Show member pathways
11.15 NGF NTRK1
6
Show member pathways
9.66 NGF NTRK1

GO Terms for Prolactin Producing Pituitary Tumor

Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 CALCA DRD2 NTRK1

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.78 CALCA NGF SST
2 aging GO:0007568 9.63 CALCA NTRK1 TP53
3 regulation of receptor activity GO:0010469 9.62 CALCA NGF PRL SST
4 activation of MAPKK activity GO:0000186 9.61 NGF NTRK1
5 response to heat GO:0009408 9.6 CALCA SST
6 feeding behavior GO:0007631 9.59 CALCA DRD2
7 phosphatidylinositol-mediated signaling GO:0048015 9.58 NGF NTRK1
8 pigmentation GO:0043473 9.58 DRD2 TYRP1
9 response to nicotine GO:0035094 9.57 DRD2 NTRK1
10 response to organonitrogen compound GO:0010243 9.56 SST TP53
11 negative regulation of cell proliferation GO:0008285 9.56 DRD2 NTRK1 SST TP53
12 cellular response to nerve growth factor stimulus GO:1990090 9.55 CALCA NTRK1
13 regulation of heart rate GO:0002027 9.54 CALCA DRD2
14 response to amino acid GO:0043200 9.52 SST TP53
15 negative regulation of blood pressure GO:0045776 9.51 CALCA DRD2
16 response to axon injury GO:0048678 9.49 DRD2 NTRK1
17 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.48 PRL TP53
18 positive regulation of Ras protein signal transduction GO:0046579 9.43 NGF NTRK1
19 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.4 CALCA NTRK1
20 neurotrophin TRK receptor signaling pathway GO:0048011 9.37 NGF NTRK1
21 G-protein coupled receptor internalization GO:0002031 9.16 CALCA DRD2
22 response to ethanol GO:0045471 9.13 DRD2 NTRK1 TP53
23 response to drug GO:0042493 8.92 DRD2 NTRK1 SST TP53

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA PRL SST

Sources for Prolactin Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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