MCID: PRL010
MIFTS: 34

Prolactin Producing Pituitary Tumor malady

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Prolactin Producing Pituitary Tumor

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Aliases & Descriptions for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 11 13
Prolactin-Producing Pituitary Tumor 48 66
Malignant Prolactin Producing Neoplasm of Pituitary Gland 11
 
Prolactin-Producing Pituitary Gland Carcinoma 66
Prolactin Secreting Tumor of Pituitary 11
Malignant Prolactinoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:5396
NCIt43 C5962, C7910

Summaries for Prolactin Producing Pituitary Tumor

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MalaCards based summary: Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary tumor, is related to erysipelas and symmastia. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways are Central carbon metabolism in cancer and Thyroid cancer. Affiliated tissues include pituitary and brain, and related mouse phenotypes are pigmentation and neoplasm.

Related Diseases for Prolactin Producing Pituitary Tumor

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Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1erysipelas10.5DRD2, PRL
2symmastia10.5DRD2, PRL
3mobitz type ii atrioventricular block10.4PRL, SST
4ovarian mucinous malignant adenofibroma10.4PRL, SST
5lipid-rich carcinoma10.4PRL, SST
6bladder mixed adenocarcinoma10.4DRD2, PRL
7hallucinogen dependence10.4DRD2, PRL
8central retinal vein occlusion10.4PRL, SST
9pituitary tumors10.4
10postural hypotension10.4PRL, SST
11lipoadenoma10.4PRL, SST
12fallopian tube clear cell adenocarcinoma10.4PRL, SST
13chronic cervicitis10.4DRD2, PRL
14syncope10.4PRL, SST
15acute myocarditis10.4PRL, SST
16loeffler endocarditis10.3PRL, SST
17nasopharyngeal disease10.3PRL, SST
18testicular fibroma10.3PRL, TP53
19pituitary adenoma, prolactin-secreting10.3PRL, SST
20cardiovascular organ benign neoplasm10.3PRL, SST
21adrenal carcinoma10.3PRL, SST
22immune system organ benign neoplasm10.3PRL, TP53
23paranasal sinus cancer, adult10.3PRL, TP53
24alcoholic liver cirrhosis10.3DRD2, PRL
25acinar cell carcinoma10.3DRD2, PRL
26prolactinoma10.2
27chronic salpingo-oophoritis10.2PRL, SST
28craniopharyngioma10.2PRL, TP53
29adenosquamous cell lung carcinoma10.2NTRK1, SST
30enthesopathy10.2DRD2, PRL
31septicemic plague10.1PRL, TP53
32epididymal neoplasm10.1CALCA, PRL
33meckel's diverticulum10.1CALCA, PRL
34restrictive cardiomyopathy10.0SST, TP53
35esophagitis10.0NTRK1, TP53
36vernal conjunctivitis10.0DRD2, PRL
37immunodeficiency, common variable, 510.0PRL, SST
38avoidant personality disorder10.0DRD2, PRL
39papillary serous adenocarcinoma10.0NTRK1, TP53
40central nervous system hemangioma10.0CALCA, PRL
41cold-induced sweating syndrome 210.0DRD2, PRL, SST
42skull base neoplasm10.0DRD2, PRL, SST
43prolactin producing pituitary tumor10.0DRD2, PRL, SST
44alpha-methylacyl-coa racemase deficiency10.0DRD2, PRL, SST
45pearson syndrome10.0CALCA, SST
46petrous apex meningioma10.0CALCA, SST
47isolated levocardia10.0CALCA, SST
48gastrinoma10.0CALCA, SST
49spinal muscular atrophy10.0CALCA, SST
50peripheral epithelioid sarcoma10.0CALCA, SST

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to prolactin producing pituitary tumor

Symptoms for Prolactin Producing Pituitary Tumor

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Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

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Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
OctreotidePhase 3, Phase 120683150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
2
DopaminePhase 3367851-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
3Dopamine agonistsPhase 3611
4
CabergolinePhase 34681409-90-754746
Synonyms:
(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
(8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-prop-2-en-1-ylergoline-8-carboxamide
1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
81409-90-7
85329-89-1 (diphosphate)
AC-14150
AC1L1HO0
AC1Q5OQ0
BIDD:GT0775
BRD-K86882815-001-01-6
BRN 6020775
C08187
C26H37N5O2
CG-101
CHEBI:3286
 
CHEMBL1201087
CID54746
Cabaser
Cabaser (TN)
Cabaseril
Cabergolina
Cabergolina [Spanish]
Cabergoline
Cabergoline (JAN/USAN/INN)
Cabergoline [USAN:BAN:INN]
Cabergolinum
Cabergolinum [Latin]
D00987
DB00248
Dostinex
Dostinex (TN)
FCE-21336
FT-0081285
Galastop
HMS2090A09
LS-64370
MolPort-003-845-557
Sogilen
UNII-LL60K9J05T
cabergoline
5
SomatostatinPhase 121238916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
6pancreatic polypeptidePhase 120
7phenylalanineNutraceuticalPhase 1155

Interventional clinical trials:

idNameStatusNCT IDPhase
1Ga-68-DOTATOC -PET in the Management of Pituitary TumoursRecruitingNCT02419664Phase 3
2Dopamine Agonist Treatment of Non-functioning Pituitary AdenomasRecruitingNCT02288962Phase 3
3Temozolomide in Treating Patients With Invasive Pituitary TumorsWithdrawnNCT00601289Phase 2
4Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation TherapyWithdrawnNCT00003514Phase 2
5Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent CancerCompletedNCT00006368Phase 1
6Indium In 111 Pentetreotide in Treating Patients With Refractory CancerTerminatedNCT00002947Phase 1
7Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain DisordersCompletedNCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

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Anatomical Context for Prolactin Producing Pituitary Tumor

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MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

34
Pituitary, Brain

Animal Models for Prolactin Producing Pituitary Tumor or affiliated genes

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MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.8DRD2, NTRK1, TP53, TYRP1
2MP:00020068.8DRD2, PRL, TP53, TYRP1
3MP:00107718.5DRD2, NTRK1, PRL, TP53, TYRP1
4MP:00053867.6DRD2, NTRK1, PRL, SST, TP53, TYRP1
5MP:00036317.3DRD2, NTRK1, PRL, SST, TP53, TYRP1

Publications for Prolactin Producing Pituitary Tumor

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Articles related to Prolactin Producing Pituitary Tumor:

idTitleAuthorsYear
1
Prolactin producing pituitary tumor]. (11808216)
2001
2
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. (9500197)
1998
3
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. (9808163)
1998
4
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. (9808162)
1998
5
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". (9531902)
1998
6
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. (7714616)
1995
7
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. (2570719)
1989
8
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. (7098479)
1982
9
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. (985824)
1976

Variations for Prolactin Producing Pituitary Tumor

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Expression for genes affiliated with Prolactin Producing Pituitary Tumor

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Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for genes affiliated with Prolactin Producing Pituitary Tumor

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Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3NTRK1, TP53
29.3NTRK1, TP53

GO Terms for genes affiliated with Prolactin Producing Pituitary Tumor

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Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430258.6CALCA, NTRK1, SST
2axonGO:00304248.4CALCA, DRD2, NTRK1

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to nicotineGO:00350949.8DRD2, NTRK1
2detection of temperature stimulus involved in sensory perception of painGO:00509659.7CALCA, NTRK1
3protein localizationGO:00081049.6DRD2, TP53
4pigmentationGO:00434739.6DRD2, TYRP1
5response to axon injuryGO:00486789.6DRD2, NTRK1
6cellular response to nerve growth factor stimulusGO:19900909.5CALCA, NTRK1
7response to heatGO:00094089.5CALCA, SST
8activation of protein kinase activityGO:00321479.4CALCA, DRD2
9feeding behaviorGO:00076319.3CALCA, DRD2
10regulation of heart rateGO:00020279.3CALCA, DRD2
11negative regulation of blood pressureGO:00457769.2CALCA, DRD2
12response to drugGO:00424938.7DRD2, NTRK1, SST
13negative regulation of cell proliferationGO:00082858.6DRD2, NTRK1, SST, TP53

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.4TP53, TYRP1
2hormone activityGO:00051798.8CALCA, PRL, SST

Sources for Prolactin Producing Pituitary Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet