MCID: PRL010
MIFTS: 31

Prolactin Producing Pituitary Tumor malady

Endocrine, Cancer categories

Summaries for Prolactin Producing Pituitary Tumor

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33MalaCards
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MalaCards: Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary tumor, is related to prolactinoma and pituitary tumors. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (prolactin), and among its related pathways are Glucocorticoid receptor regulatory network and Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds sulpiride and flesinoxan have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Prolactin Producing Pituitary Tumor

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Endocrine


Aliases & Descriptions:

prolactin producing pituitary tumor 8
prolactin-producing pituitary tumor 45 61
malignant prolactin producing neoplasm of pituitary gland 8
prolactin producing pituitary gland carcinoma 61
prolactin secreting tumor of pituitary 8
malignant prolactinoma 8


External Ids:

Disease Ontology8 DOID:5396
NCIt40 C7910

Related Diseases for Prolactin Producing Pituitary Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1prolactinoma30.8POMC, TRH, AIP, SST, PRL
2pituitary tumors30.8PRL, SST, AIP, TRH, POMC
3amenorrhea30.4PRL, TRH, POMC
4infertility10.0PRL
5anovulation10.0PRL
6gynecomastia10.0PRL
7zollinger-ellison syndrome10.0SST
8hypogonadotropism10.0PRL
9gastrinoma10.0SST
10goiter10.0TRH
11hyperthyroxinemia10.0TRH
12euthyroid sick syndrome10.0TRH
13exophthalmos10.0TRH
14hyperinsulinism10.0SST
15duodenal ulcer10.0SST
16addison's disease10.0POMC
17schizoaffective disorder10.0PRL
18prion disease10.0POMC
19hypertension10.0POMC
20adrenocortical carcinoma10.0POMC
21neurogenic diabetes insipidus10.0POMC
22dementia10.0TRH
23peptic ulcer10.0SST
24adrenal adenoma10.0POMC
25hypokalemia10.0POMC
26ganglioneuroma10.0POMC
27cocaine dependence10.0POMC
28arthritis10.0POMC
29leydig cell tumor10.0POMC
30wermer syndrome10.0SST, PRL
31klinefelter's syndrome10.0TRH, PRL
32paraganglioma10.0SST
33thyroid cancer10.0TRH, SST
34acth-secreting pituitary adenoma10.0PRL, POMC
35schizophrenia10.0PRL, TRH
36acth deficiency10.0POMC, PRL
37anorexia nervosa10.0POMC, PRL
38pituitary cancer10.0POMC, PRL
39chronic fatigue syndrome10.0POMC
40insulin resistance10.0SST
41growth hormone deficiency10.0POMC, PRL
42sheehan syndrome10.0PRL, POMC
43thyrotropin deficiency, isolated10.0POMC, PRL
44carney complex10.0POMC, AIP
45bronchial endocrine tumor10.0SST, POMC
46panhypopituitarism10.0POMC, PRL
47precocious puberty10.0PRL, POMC
48polycystic ovary syndrome10.0PRL, POMC
49cushing's syndrome10.0POMC, SST
50melancholia10.0TRH, POMC

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to prolactin producing pituitary tumor

Clinical Features for Prolactin Producing Pituitary Tumor

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Prolactin Producing Pituitary Tumor

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Search CenterWatch for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

Anatomical Context for Prolactin Producing Pituitary Tumor

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33MalaCards
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MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

33
Pituitary

Animal Models for Prolactin Producing Pituitary Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4POMC, TRH, AIP, PRL
2MP:00053767.2POMC, TRH, AIP, SST, PRL

Publications for Prolactin Producing Pituitary Tumor

Sources:
51PubMed
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Articles related to Prolactin Producing Pituitary Tumor:

(show all 11)
idTitleAuthorsYear
1
Differential gene expression in models of pituitary prolactin-producing tumoral cells. (19407504)
2009
2
Prolactin-producing pituitary adenoma with incomplete neuronal transformation: an intermediate adenoma-neuronal tumor. (15173951)
2004
3
Prolactin producing pituitary tumor]. (11808216)
2001
4
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. (9500197)
1998
5
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. (9808162)
1998
6
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". (9531902)
1998
7
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. (9808163)
1998
8
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. (7714616)
1995
9
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. (2570719)
1989
10
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. (7098479)
1982
11
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. (985824)
1976

Genetic Variations for Prolactin Producing Pituitary Tumor

Expression for genes affiliated with Prolactin Producing Pituitary Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prolactin Producing Pituitary Tumor

Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for genes affiliated with Prolactin Producing Pituitary Tumor

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 30KEGG
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Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4POMC, PRL
2
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.3POMC, TRH
3
Hide members
8.1PRL, SST, TRH, POMC
4
Hide members
8.1POMC, TRH, SST, PRL

Compounds for genes affiliated with Prolactin Producing Pituitary Tumor

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
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Compounds related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1sulpiride45 29 1111.8TRH, PRL
2flesinoxan459.8PRL, POMC
3acth 1-24459.8POMC, PRL
4metoclopramide45 1110.8TRH, PRL
5ipsapirone45 2910.8POMC, PRL
611 deoxycortisol459.7POMC, PRL
7mirtazapine50 45 1111.7POMC, PRL
8naltrexone45 50 29 1112.6POMC, PRL
9apomorphine45 29 1111.6TRH, PRL
10quinagolide459.6PRL, SST
1117-hydroxyprogesterone45 2410.6PRL, POMC
125-hydroxytryptophan459.5PRL, SST
13buserelin45 29 1111.5PRL, SST
14lanreotide45 2910.5PRL, SST
15pitressin459.4POMC, SST
16cabergoline29 45 1111.4SST, PRL
17methimazole45 2 1111.3POMC, TRH
18loperamide45 11 2411.3SST, POMC
19fenfluramine29 45 1111.3PRL, TRH, POMC
20triiodothyronine459.3PRL, TRH, POMC
21haloperidol45 29 2 50 1113.3PRL, TRH, POMC
22metyrapone60 45 1111.3POMC, SST
23cocaine45 1110.3POMC, TRH, PRL
24ghrp459.1PRL, SST, TRH
25pyridostigmine45 1110.1PRL, SST, TRH
26domperidone45 29 1111.1PRL, SST, TRH
27dehydroepiandrosterone sulfate459.1POMC, PRL
28levodopa45 1110.1TRH, SST, PRL
29ketoconazole45 29 11 2412.0POMC, SST
30hexarelin45 2910.0PRL, SST, POMC
315-hydroxytryptamine458.9PRL, SST, POMC
32estradiol45 11 2410.9PRL, TRH, POMC
33midazolam45 50 1110.9POMC, SST
34epinephrine45 11 2410.9POMC, SST, PRL
35gaba458.8POMC, TRH, SST
36acetylcholine45 50 29 11 2412.7POMC, TRH, SST
37bromocriptine29 45 1110.5POMC, TRH, SST, PRL
38naloxone45 50 29 1111.5PRL, SST, TRH, POMC
39clonidine45 29 1110.5PRL, SST, TRH, POMC
40octreotide45 60 29 1111.5POMC, TRH, SST, PRL
41hydrocortisone45 2 60 1111.5POMC, TRH, SST, PRL
42thyroxine45 249.5POMC, TRH, SST, PRL
43acth458.5POMC, TRH, SST, PRL
44gnrh458.5PRL, SST, TRH, POMC
45norepinephrine45 11 2410.5POMC, TRH, SST, PRL
46dopamine45 29 11 2411.5POMC, TRH, SST, PRL
47testosterone45 60 11 2411.4PRL, SST, TRH, POMC
48dexamethasone45 50 29 1111.4POMC, TRH, SST, PRL
49arginine458.4PRL, SST, TRH, POMC
50glucose458.3PRL, SST, TRH, POMC

GO Terms for genes affiliated with Prolactin Producing Pituitary Tumor

Sources:
16Gene Ontology
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Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.6POMC, TRH, PRL
2extracellular regionGO:0055768.1POMC, TRH, SST, PRL

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:0454719.5TRH, PRL
2response to nutrientGO:0075848.9SST, PRL
3cell-cell signalingGO:0072678.4POMC, TRH, SST

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.6POMC, SST, PRL

Products for genes affiliated with Prolactin Producing Pituitary Tumor

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Sources for Prolactin Producing Pituitary Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet