MCID: PRL010
MIFTS: 31

Prolactin Producing Pituitary Tumor malady

Cancer diseases, Endocrine diseases categories

Aliases & Classifications for Prolactin Producing Pituitary Tumor

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Sources:
10Disease Ontology, 47Novoseek, 65UMLS, 42NCIt
See all sources

Aliases & Descriptions for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 10
Prolactin-Producing Pituitary Tumor 47 65
Malignant Prolactin Producing Neoplasm of Pituitary Gland 10
 
Prolactin-Producing Pituitary Gland Carcinoma 65
Prolactin Secreting Tumor of Pituitary 10
Malignant Prolactinoma 10


Classifications:



External Ids:

Disease Ontology10 DOID:5396
NCIt42 C7910

Summaries for Prolactin Producing Pituitary Tumor

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MalaCards based summary: Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary tumor, is related to pituitary tumors and prolactinoma. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and PI3K-Akt signaling pathway. Affiliated tissues include pituitary, and related mouse phenotypes are pigmentation and renal/urinary system.

Related Diseases for Prolactin Producing Pituitary Tumor

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Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary tumors10.8
2prolactinoma10.6
3amenorrhea10.3
4goiter10.3
5hyperthyroidism10.3
6ainhum10.2DRD2, PRL
7nephrogenic adenoma of urinary bladder10.2DRD2, PRL
8brill-zinsser disease10.2DRD2, PRL
9large cell acanthoma10.2DRD2, TYRP1
10schizoid personality disorder10.2DRD2, PRL
11conus medullaris neoplasm10.2IGF1, PRL
12appendiceal l-cell glucagon-like peptide producing tumor10.2IGF1, PRL
13hypothryoidism, congenital, nongoitrous 410.2IGF1, PRL
14graphite pneumoconiosis10.2PRL, TP53
15carotid artery occlusion10.1DRD2, PRL
16posterior cerebral artery infarction10.1PRL, TP53
17cluttering10.1CALCA, PRL
18angular blepharoconjunctivitis10.1IGF1, PRL
19vulvar apocrine adenocarcinoma10.1CALCA, PRL
20pituitary hormone deficiency, combined, 210.1IGF1, PRL
21pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.1CALCA, PRL
22substance dependence10.1DRD2, PRL
23opportunistic bacterial infectious disease10.1DRD2, IGF1
24brain ischemia10.1DRD2, IGF1
25pertussis10.1DRD2, PRL
26cutaneous mastocytosis10.1IGF1, PRL
27mutiple parosteal osteochondromatous proliferations10.1IGF1, TP53
28selective iga deficiency disease10.1CALCA, TP53
29primary eye hypotony10.1CALCA, TP53
30gastric cardia adenocarcinoma10.1PRL, SST
31placenta disease10.1PRL, SST
32sweat gland carcinoma10.1PRL, SST
33diabetes insipidus10.0IGF1, PRL
34duane retraction syndrome10.0CALCA, IGF1
35pulmonary type ovarian small cell carcinoma10.0CALCA, IGF1
36pleuropneumonia10.0PRL, SST
37fundus dystrophy10.0PRL, SST
38pituitary adenoma, acth-secreting10.0PRL, SST
39hypopyon10.0IGF1, PRL
40testis rhabdomyosarcoma10.0IGF1, SST
41brachyolmia10.0CALCA, TP53
42progeria10.0PRL, SST
43human immunodeficiency virus infectious disease10.0IGF1, SST
44adrenocortical carcinoma10.0PRL, SST
45central nervous system primitive neuroectodermal neoplasm10.0IGF1, PRL, TP53
46alcoholic hepatitis10.0DRD2, PRL
47breast duct papilloma10.0IGF1, PRL, TP53
48weaver johnson syndrome10.0CALCA, SST
49aquagenic pruritus10.0CALCA, SST
50nasal cavity carcinoma in situ10.0CALCA, SST

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to prolactin producing pituitary tumor

Symptoms for Prolactin Producing Pituitary Tumor

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Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

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Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DopamineapprovedPhase 3281462-31-7, 51-61-6681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine Hcl
Dopamine Hydrochloride
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
 
KBio1_000780
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
2
CabergolineapprovedPhase 34281409-90-754746
Synonyms:
(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
(8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-prop-2-en-1-ylergoline-8-carboxamide
1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
81409-90-7
85329-89-1 (diphosphate)
AC-14150
AC1L1HO0
AC1Q5OQ0
BIDD:GT0775
BRD-K86882815-001-01-6
BRN 6020775
C08187
C26H37N5O2
CG-101
CHEBI:3286
 
CHEMBL1201087
CID54746
Cabaser
Cabaser (TN)
Cabaseril
Cabergolina
Cabergolina [Spanish]
Cabergoline
Cabergoline (JAN/USAN/INN)
Cabergoline [USAN:BAN:INN]
Cabergolinum
Cabergolinum [Latin]
D00987
DB00248
Dostinex
Dostinex (TN)
FCE-21336
FT-0081285
Galastop
HMS2090A09
LS-64370
MolPort-003-845-557
Sogilen
UNII-LL60K9J05T
cabergoline
3EdotreotidePhase 3, Phase 120
4Dopamine AgonistsPhase 3476
5RadiopharmaceuticalsPhase 3345
6
Octreotideapproved, investigationalPhase 119183150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
 
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Ocphyl
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide acetate
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatin
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
7
SomatostatinPhase 114151110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
8pancreatic polypeptidePhase 120
9phenylalanineNutraceuticalPhase 1130

Interventional clinical trials:

idNameStatusNCT IDPhase
1Ga-68-DOTATOC -PET in the Management of Pituitary TumoursRecruitingNCT02419664Phase 3
2Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas (NFPAs) - a Randomized Controlled TrialRecruitingNCT02288962Phase 3
3Temozolomide in Treating Patients With Invasive Pituitary TumorsWithdrawnNCT00601289Phase 2
4Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation TherapyWithdrawnNCT00003514Phase 2
5Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent CancerCompletedNCT00006368Phase 1
6Indium In 111 Pentetreotide in Treating Patients With Refractory CancerTerminatedNCT00002947Phase 1
7Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain DisordersCompletedNCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

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Anatomical Context for Prolactin Producing Pituitary Tumor

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MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

33
Pituitary

Animal Models for Prolactin Producing Pituitary Tumor or affiliated genes

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MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.6DRD2, TP53, TYRP1
2MP:00053678.6CALCA, DRD2, IGF1, TP53
3MP:00053908.3CALCA, DRD2, IGF1, TP53, TYRP1
4MP:00053898.2DRD2, IGF1, PRL, TP53, TYRP1
5MP:00107717.7CALCA, DRD2, IGF1, PRL, TP53, TYRP1
6MP:00020067.6CALCA, DRD2, IGF1, PRL, TP53, TYRP1
7MP:00053867.3CALCA, DRD2, PRL, SST, TP53, TYRP1
8MP:00036316.6CALCA, DRD2, IGF1, PRL, SST, TP53
9MP:00053766.4CALCA, DRD2, IGF1, PRL, SST, TP53

Publications for Prolactin Producing Pituitary Tumor

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Articles related to Prolactin Producing Pituitary Tumor:

idTitleAuthorsYear
1
Prolactin producing pituitary tumor]. (11808216)
2001
2
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. (9500197)
1998
3
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. (9808162)
1998
4
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". (9531902)
1998
5
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. (9808163)
1998
6
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. (7714616)
1995
7
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. (2570719)
1989
8
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. (7098479)
1982
9
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. (985824)
1976

Variations for Prolactin Producing Pituitary Tumor

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Expression for genes affiliated with Prolactin Producing Pituitary Tumor

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Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for genes affiliated with Prolactin Producing Pituitary Tumor

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Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CALCA, IGF1
29.1IGF1, PRL, TP53

GO Terms for genes affiliated with Prolactin Producing Pituitary Tumor

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Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1pigmentationGO:004347310.1DRD2, TYRP1
2neurological system process involved in regulation of systemic arterial blood pressureGO:00019769.9CALCA, DRD2
3activation of protein kinase activityGO:00321479.9CALCA, DRD2
4positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:00514829.9CALCA, DRD2
5feeding behaviorGO:00076319.8CALCA, DRD2
6regulation of multicellular organism growthGO:00400149.7IGF1, PRL
7G-protein coupled receptor internalizationGO:00020319.6CALCA, DRD2
8negative regulation of blood pressureGO:00457769.5CALCA, DRD2
9regulation of heart rateGO:00020279.4CALCA, DRD2
10cell proliferationGO:00082839.3IGF1, PRL, TP53
11protein localizationGO:00081049.2DRD2, TP53
12response to heatGO:00094088.7CALCA, IGF1, SST
13response to drugGO:00424938.6DRD2, SST, TP53
14negative regulation of cell proliferationGO:00082858.4DRD2, IGF1, SST, TP53

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.5TP53, TYRP1
2hormone activityGO:00051798.0CALCA, IGF1, PRL, SST

Sources for Prolactin Producing Pituitary Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet