FIPA
MCID: PRL009
MIFTS: 71

Prolactinoma (FIPA) malady

Endocrine diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases categories

Summaries for Prolactinoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A prolactinoma is a benign tumor (adenoma) of the pituitary gland that produces a hormone called... more...

MalaCards: Prolactinoma, also known as pituitary adenoma, prolactin-secreting, is related to adenoma and pituitary adenoma. An important gene associated with Prolactinoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are GPCRs, Other and G alpha (q) signalling events. The compounds l-362,855 and bim 23627 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and thyroid, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Description from OMIM:46 600634,102200

Aliases & Classifications for Prolactinoma

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60UMLS, 8Disease Ontology, 44Novoseek, 48Orphanet, 9diseasecard, 46OMIM, 42NIH Rare Diseases, 22GTR, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
familial isolated pituitary adenoma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

prolactinoma 8 44 48 60
pituitary adenoma, prolactin-secreting 8 9 46
prolactinoma, familial 42 22
prolactin-secreting pituitary adenoma 48
pituitary adenoma, familial isolated 60
familial isolated pituitary adenoma 48
multiple gastrointestinal atresias 60
prl-secreting pituitary adenoma 48
prolactinoma of pituitary gland 8
pituitary lactotrophic adenoma 48
familial prolactinoma 8
lactotroph adenoma 48
prloma 48
fipa 48


External Ids:

Disease Ontology8 DOID:5394
MeSH34 D015175
NCIt39 C3342
MESH via Orphanet35 D015175
ICD10 via Orphanet26 D35.2, E22.1
SNOMED-CT via Orphanet57 134209002, 34337008
UMLS via Orphanet61 C0033375

Related Diseases for Prolactinoma

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17GeneCards, 18GeneDecks
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Diseases related to Prolactinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.7DRD2, GNRHR, TRHR, AIP, SSTR3, SSTR4
2pituitary adenoma30.7PTTG1, FGF4, POU1F1, TRH, TRHR, AIP
3hyperprolactinemia30.6DRD2, PRL, TRH
4acromegaly30.5AIP, SSTR1, SSTR2, SSTR5, PRL, GHSR
5pituitary apoplexy30.4PRL, TRH
6thyroiditis30.3TRH
7hyperparathyroidism30.1MEN1
8hypogonadism30.1POU1F1, TRH, PRL, GNRHR
9meningioma30.1MEN1, SSTR5, SSTR2
10breast cancer30.0GNRHR, CHGB, SSTR2, NGFR, FGF4, PTTG1
11exophthalmos30.0TRH
12craniopharyngioma29.7PRL, TRH
13gastrinoma29.7SSTR1, SSTR2, SSTR5, MEN1
14obesity29.7DRD2, GHSR, TRH
15empty sella syndrome29.7POU1F1, PRL
16adenocarcinoma29.7GNRHR, MEN1, CHGB, SSTR2, SSTR1, POU1F1
17aip-related familial isolated pituitary adenomas10.5
18mixed cell adenoma10.3
19pseudotumor cerebri10.3
20psychotic disorder10.3
21multiple intestinal atresia10.2
22familial meningioma10.2
23gangliocytoma10.1
24hydrocephalus10.1
25imperforate anus10.1
26familial isolated pituitary adenoma10.1
27systemic lupus erythematosus10.1
28adrenal adenoma10.1
29functioning pituitary adenoma10.1
30lupus erythematosus10.1
31schizophrenia10.1
32transsexualism10.0
33autoimmune thyroiditis10.0
34neuronitis10.0
35schizoaffective disorder10.0
36gynecomastia10.0
37obstructive hydrocephalus10.0
38pathological gambling10.0
39osteoporosis10.0
40cervicitis10.0
41leukemia10.0
42meningitis10.0
43pancreatitis10.0
44personality disorder10.0
45turner syndrome10.0
46gigantism10.0AIP, PRL
47anovulation10.0PRL
48endogenous depression10.0TRH
49acth deficiency10.0POU1F1, PRL
50addison's disease10.0GNRHR

Graphical network of the top 20 diseases related to Prolactinoma:



Diseases related to prolactinoma

Clinical Features for Prolactinoma

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46OMIM
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Clinical features from OMIM:

600634,102200

Clinical synopsis from OMIM:

600634

Drugs & Therapeutics for Prolactinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Prolactinoma

Drug clinical trials:

Search ClinicalTrials for Prolactinoma

Search NIH Clinical Center for Prolactinoma

Search CenterWatch for Prolactinoma

Genetic Tests for Prolactinoma

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22GTR
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Genetic tests related to Prolactinoma:

id Genetic test Affiliating Genes
1 Prolactinoma, Familial22

Anatomical Context for Prolactinoma

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32MalaCards
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MalaCards organs/tissues related to Prolactinoma:

32
Pituitary, Bone, Thyroid, Breast, Heart, Brain, Ovary, Testes, Colon, Hypothalamus, T cells, Prostate, Skin, Kidney, Spinal cord

Animal Models for Prolactinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Prolactinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.3NGFR, SSTR2, GHSR, MEN1, DRD2, GNRHR
2MP:000537910.3CORT, GNRHR, DRD2, MEN1, GHRHR, PRL
3MP:000537810.2GHRHR, MEN1, DRD2, GNRHR, CORT, GHSR
4MP:000538610.2CORT, DRD2, GHRHR, GHSR, PRL, SSTR2
5MP:000363110.2PRL, GHRHR, MEN1, DRD2, CHGB, SSTR2
6MP:000538910.2GNRHR, DRD2, MEN1, GHRHR, PRL, TRHR
7MP:000537610.2PTTG1, CORT, GNRHR, DRD2, MEN1, GHRHR
8MP:001077110.1GNRHR, DRD2, GHRHR, AIP

Publications for Prolactinoma

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50PubMed
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Articles related to Prolactinoma:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
The prevalence and natural history of pituitary hemorrhage in prolactinoma. (23585661)
2013
2
Regarding "A Risperidone-induced Prolactinoma Resolved When A Woman with Schizoaffective Disorder Switched to Ziprasidone: A Case Report". (23556137)
2013
3
Superficial siderosis of the central nervous system due to chronic hemorrhage from a giant invasive prolactinoma. (23664407)
2013
4
A case of an ectopic prolactinoma. (21780951)
2012
5
Vertebral fractures in males with prolactinoma. (21479837)
2011
6
'Prolactinoma: are dopamine agonists still first choice?'. (22435904)
2011
7
Dopamine agonists in the treatment of prolactinoma: are they still first choice? (21138511)
2011
8
Proteomic analysis of prolactinoma cells by immuno-laser capture microdissection combined with online two-dimensional nano-scale liquid chromatography/mass spectrometry. (20205839)
2010
9
Giant prolactinoma in an elderly man. (20649697)
2010
10
Extensive personal experience. Validation of prolactin levels in menstrual disorders and in prolactinomas. (20045798)
2009
11
The cabergoline-resistant prolactinoma patient: new challenges. (19056842)
2008
12
Combined gangliocytoma and prolactinoma of the pituitary gland. (18651251)
2008
13
Vitex agnus castus might enrich the pharmacological armamentarium for medical treatment of prolactinoma. (17602822)
2007
14
Temozolomide in the treatment of an invasive prolactinoma resistant to dopamine agonists. (17285366)
2007
15
Treatment of pituitary gland hyperfunction: from acromegaly to prolactinoma]. (17033781)
2006
16
Metastatic prolactinoma: case report with immunohistochemical assessment for p53 and Ki-67 antigens. (16258673)
2005
17
Pharmacologic resistance in prolactinoma patients. (16411068)
2005
18
Pituitary abscess associated with prolactinoma. (15177403)
2004
19
Dopamine resistance of prolactinomas. (14674720)
2003
20
Prolactinomas: neurosurgical aspects]. (11965418)
2002
21
Prolactinoma with preferential infrasellar extension: a report of two cases. (11386812)
2001
22
Giant prolactinoma and hook effect. (11087799)
2000
23
Sarcomatous transformation of a prolactinoma associated with development of a fatal internal carotid artery pseudoaneurysm--case report. (10979267)
2000
24
Clinical management of prolactinomas. (10909431)
1999
25
Quantitative and functional expression of somatostatin receptor subtypes in human prolactinomas. (10487698)
1999
26
Two case reports of breast carcinoma associated with prolactinoma. (9271027)
1997
27
Total capsular calcification in a prolactinoma--case report. (8937096)
1996
28
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
29
Prolactinoma. (7704764)
1994
30
Prolactinoma and body weight: a retrospective study. (1957557)
1991
31
Results of primary treatment with bromocriptine of prolactinomas with extrasellar extension. (2311021)
1990
32
Spontaneous prolactin transplantable tumor in the Wistar/Furth rat (SMtTW): a new animal model of human prolactinoma. (2354457)
1990
33
Alteration of prolactin secretion after transsphenoidal adenomectomy for prolactinomas]. (2223270)
1990
34
Hypogonadism of male prolactinomas: relation to pulsatile secretion of LH. (2099670)
1990
35
Ultrastructural study of prolactinoma after bromocriptine therapy. (3251048)
1988
36
Sequential prolactin evaluation of a "cured" patient with recurrence of prolactinoma. (3812533)
1987
37
Transient intrasellar collection of air during bromocriptine treatment of a prolactinoma. (3762918)
1986
38
Amyloid formation in prolactinoma. (3510059)
1986
39
Co-existing prolactinoma with primary empty sella. (4044485)
1985
40
Dramatic and rapid shrinkage of a massive invasive prolactinoma with bromocriptine: a case report. (4028456)
1985
41
Hormonal regulation of prolactin release by human prolactinoma cells cultured in serum-free conditions. (3932176)
1985
42
Follow-up of prolactin levels in long-term oestrogen-treated male-to-female transsexuals with regard to prolactinoma induction. (3157511)
1985
43
Evaluation of dopaminergic tone in hyperprolactinemia. III. Thyroid-stimulating hormone response to metoclopramide in differential diagnosis and postoperative follow-up of prolactinoma patients. (4046835)
1985
44
The effect of thioridazine on prolactinoma growth in a schizophrenic man: case report. (4065553)
1985
45
Prolactin dynamics and tumour size in the prediction of surgical outcome for prolactinoma. (3920723)
1985
46
Effect of [Asu1,7]eel calcitonin on prolactin release in normal subjects and patients with prolactinoma. (3920850)
1985
47
Granulomatous mastitis associated with a pituitary prolactinoma. (6538433)
1984
48
Bromocriptine-induced regression of a suprasellar extending prolactinoma during pregnancy. (6725868)
1984
49
Growth of a prolactinoma during pregnancy. Case report and review. (7459293)
1981
50
Obstetrics and gynecology-epitomes of progress: the prolactinoma problem: long-term issues and short-term answers. (18748883)
1981

Genetic Variations for Prolactinoma

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Expression for genes affiliated with Prolactinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prolactinoma

Search GEO for disease gene expression data for Prolactinoma.

Pathways for genes affiliated with Prolactinoma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Prolactinoma

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28IUPHAR, 44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Prolactinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1l-362,8552810.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
2bim 236272810.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
3ke 1082810.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
4cgp 239962810.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
5[d-tyr8]cyn 1548062810.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
6[l-tyr8]cyn 1548062810.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
7estrogen4410.8TRH, PTTG1
8bim 234542810.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
9[125i]ltt-srif-282810.8SSTR3, SSTR5, SSTR2, SSTR1, SSTR4
10srif-282810.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
11srif-142810.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
12[125i]tyr10-cst142810.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
13bim 230522810.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
14[125i]cgp 239962810.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
15lanreotide44 2811.7SSTR3, SSTR4, SSTR1, SSTR2, SSTR5, PRL
16cst-172810.7SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
17(1r,1s,3r/1r,1r,3s)-l-054,2645910.7SSTR4, SSTR1, SSTR2, SSTR5, SSTR3
18som-2302810.7SSTR5, SSTR2, SSTR1, SSTR3
19cst-142810.7SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
20cyclosomatostatin5910.7SSTR5, SSTR3, SSTR4, SSTR1, SSTR2
21vapreotide28 44 1112.7CORT, GHSR, SSTR5, SSTR2, SSTR3
22cyn 1548065910.7SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
23des-aa5-[d-trp8]srif2810.7SSTR5, SSTR1, SSTR4, SSTR3
24pasireotide44 1111.7SSTR5, SSTR2, SSTR1, SSTR3
25somatostatin59 2411.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
26ghrp4410.7GHRHR, GHSR, PRL, TRH
27bromocriptine28 44 1112.7GNRHR, PRL, TRH, POU1F1
28l-363,3012810.7SSTR3, SSTR2, SSTR5
29hexarelin44 2811.7CORT, GHRHR, GHSR, PRL
30bim 230562810.7SSTR5, SSTR2, SSTR3
31ribonucleic acid4410.7GNRHR, GHRHR, GHSR, PRL, SSTR5, SSTR2
32boc-ate2810.7SSTR5, SSTR2, SSTR3
33dopamine44 28 11 2413.7PTTG1, NGFR, TRH, SSTR1, SSTR2, SSTR5
34acth4410.6CORT, GHSR, PRL, CHGB, SSTR5, SSTR2
35[111in,90y]dota-oc2810.6SSTR5, SSTR2, SSTR3
36octreotide44 59 28 1113.6SSTR5, PRL, GHSR, DRD2, CORT, SSTR2
37[111in,90y]dota-lan2810.6SSTR5, SSTR2, SSTR3
38noc-ate2810.6SSTR5, SSTR2, SSTR3
39thymidine44 2411.6GNRHR, MEN1, SSTR5, SSTR2, TRH, POU1F1
40prl-29152810.6SSTR5, SSTR4, SSTR3
41mk-6782810.5SSTR5, SSTR2, SSTR3
42adenylate4410.5CORT, GNRHR, DRD2, GHRHR, GHSR, SSTR2
43bim 230232810.5SSTR5, SSTR2, SSTR3
44tyrosine4410.5CORT, GNRHR, MEN1, CHGB, SSTR5, SSTR2
45[111in]dota-boc-ate2810.5SSTR5, SSTR2, SSTR3
46calcium44 49 11 2413.5CHGB, GHSR, GHRHR, MEN1, GNRHR, SSTR5
47nc 4-28b2810.4SSTR2, SSTR1, SSTR3
48bim 230682810.4SSTR2, SSTR4, SSTR3
49[111in]dota-noc2810.3SSTR3, SSTR2, SSTR5
50[111in]dota-noc-ate2810.1SSTR5, SSTR2, SSTR3

GO Terms for genes affiliated with Prolactinoma

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16Gene Ontology
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Cellular components related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.4TRH, CHGB, PRL, GHRHR
2integral to plasma membraneGO:00588710.1NGFR, GNRHR, DRD2, SSTR5, SSTR2, SSTR1
3plasma membraneGO:0058869.8SSTR5, GHSR, GHRHR, DRD2, GNRHR, SSTR2

Biological processes related to Prolactinoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of multicellular organism growthGO:04001810.7DRD2, GHRHR, GHSR, POU1F1
2cellular response to glucocorticoid stimulusGO:07138510.7SSTR3, SSTR4, SSTR2
3cellular response to estradiol stimulusGO:07139210.7SSTR2, SSTR1, SSTR3
4somatostatin signaling pathwayGO:03817010.7SSTR3, SSTR5
5somatotropin secreting cell developmentGO:06013310.7POU1F1, GHRHR
6forebrain developmentGO:03090010.7SSTR2, SSTR1, SSTR4, SSTR3
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
8cerebellum developmentGO:02154910.7SSTR2, SSTR1, SSTR3
9response to starvationGO:04259410.6SSTR2, SSTR1, SSTR3
10negative regulation of cell proliferationGO:00828510.6POU1F1, DRD2, MEN1, SSTR5, SSTR2, SSTR1
11cell-cell signalingGO:00726710.6FGF4, TRH, SSTR3, SSTR1, SSTR2
12response to nutrientGO:00758410.6SSTR1, SSTR2, PRL
13positive regulation of growth hormone secretionGO:06012410.6DRD2, GHRHR
14peristalsisGO:03043210.5DRD2, SSTR2
15G-protein coupled receptor signaling pathwayGO:00718610.5GNRHR, GHSR, SSTR5, SSTR4, TRHR
16growth hormone secretionGO:03025210.5GHRHR, GHSR
17positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.4GHRHR, GHSR
18hormone-mediated signaling pathwayGO:00975510.4TRH, GHSR
19determination of adult lifespanGO:00834010.3GHRHR, POU1F1
20spermatogenesisGO:00728310.1PTTG1, SSTR3, SSTR1, SSTR2

Molecular functions related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth hormone-releasing hormone receptor activityGO:01652010.4GHSR, GHRHR
2somatostatin receptor activityGO:00499410.0SSTR3, SSTR4, SSTR1, SSTR2, SSTR5

Products for genes affiliated with Prolactinoma

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Sources for Prolactinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet