FIPA
MCID: PRL009
MIFTS: 63

Prolactinoma (FIPA) malady

Genetic diseases, Rare diseases, Reproductive diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases categories

Summaries for Prolactinoma

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 A prolactinoma is a benign tumor (adenoma) of the pituitary gland that produces a hormone called... more...

MalaCards: Prolactinoma, also known as pituitary adenoma, prolactin-secreting, is related to hyperprolactinemia and gigantism. An important gene associated with Prolactinoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Glucocorticoid receptor regulatory network and Peptide ligand-binding receptors. The compounds ghrp and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and bone, and related mouse phenotypes are reproductive system and immune system.

Description from OMIM:48 600634,102200

Aliases & Classifications for Prolactinoma

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9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 23GTR, 48OMIM, 46Novoseek, 50Orphanet, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
prolactinoma:
Prevalence: 6-9/10000; Age of onset: Adolescence / Young adulthood; Age of death: Normal
familial isolated pituitary adenoma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

prolactinoma 9 46 50 63
pituitary adenoma, prolactin-secreting 9 10 48
prolactinoma, familial 44 23
prolactin-secreting pituitary adenoma 50
pituitary adenoma, familial isolated 63
familial isolated pituitary adenoma 50
multiple gastrointestinal atresias 63
prolactinoma of pituitary gland 9
prl-secreting pituitary adenoma 50
pituitary lactotrophic adenoma 50
familial prolactinoma 9
lactotroph adenoma 50
prloma 50
fipa 50


External Ids:

Disease Ontology9 DOID:5394
MeSH36 D015175
NCIt41 C3342
MESH via Orphanet37 D015175
ICD10 via Orphanet27 D35.2, E22.1
SNOMED-CT via Orphanet60 134209002, 34337008
UMLS via Orphanet64 C0033375

Related Diseases for Prolactinoma

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18GeneCards, 19GeneDecks
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Diseases related to Prolactinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1hyperprolactinemia30.8CGB, PRL
2gigantism30.6AIP, PRL
3pituitary apoplexy30.6PRL
4psychotic disorder30.5CNTF, PRL
5multiple endocrine neoplasia30.5MEN1, CHGB
6adenoma30.4AIP, POU1F1, CHGB, PRL, SSTR5, MEN1
7acromegaly30.4AIP, PRL, SSTR5, MEN1, GHRHR, TRHR
8pituitary tumors30.3MEN1, GHRHR, TRHR, SSTR5, PRL, CHGB
9hypogonadism30.2POU1F1, PRL
10pituitary adenoma30.1TRHR, AIP, POU1F1, CHGB, PRL, SSTR5
11growth hormone deficiency30.1GHRHR, PRL, POU1F1
12schizophrenia30.1CNTF, PRL, CHGB
13empty sella syndrome29.9PRL, POU1F1
14gastrinoma29.9SSTR5, MEN1
15breast cancer29.9POU1F1, PRL, SSTR5, MEN1, GHRHR, CGB
16glucagonoma29.8CHGB, SSTR5, MEN1
17adenocarcinoma29.6POU1F1, CHGB, MEN1, CGB
18familial isolated pituitary adenoma10.9
19aip-related familial isolated pituitary adenomas10.5
20somatostatin analog10.5
21headache10.3
22growth hormone secreting pituitary adenoma10.3
23pseudotumor cerebri10.3
24thyroiditis10.2
25gangliocytoma10.2
26hydrocephalus10.2
27systemic lupus erythematosus10.1
28hyperparathyroidism10.1
29lupus erythematosus10.1
30meningioma10.1
31pituitary carcinoma10.1
32thyrotropin deficiency, isolated10.1PRL, POU1F1
33panhypopituitarism10.1PRL, POU1F1
34pituitary hypoplasia10.1GHRHR, POU1F1
35acth deficiency10.1POU1F1, PRL
36pituitary gland disease10.1MEN1, PRL
37hormone producing pituitary cancer10.1AIP, MEN1
38hypopituitarism10.1POU1F1, PRL
39growth retardation-mild developmental delay-chronic hepatitis syndrome10.1POU1F1, GHRHR
40carney complex10.1MEN1, AIP
41wermer syndrome10.1AIP, MEN1
42dwarfism10.0GHRHR, POU1F1
43klinefelter's syndrome10.0PRL, CGB
44short stature10.0POU1F1, PRL, GHRHR
45autoimmune thyroiditis10.0
46transsexualism10.0
47obstructive sleep apnea10.0
48neuronitis10.0
49exophthalmos10.0
50schizoaffective disorder10.0

Graphical network of the top 20 diseases related to Prolactinoma:



Diseases related to prolactinoma

Symptoms for Prolactinoma

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48OMIM
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Symptoms by clinical synopsis from OMIM:

600634

Clinical features from OMIM:

600634,102200

Drugs & Therapeutics for Prolactinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Prolactinoma

Drug clinical trials:

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Search NIH Clinical Center for Prolactinoma

Search CenterWatch for Prolactinoma

Genetic Tests for Prolactinoma

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23GTR
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Genetic tests related to Prolactinoma:

id Genetic test Affiliating Genes
1 Prolactinoma, Familial23

Anatomical Context for Prolactinoma

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34MalaCards
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MalaCards organs/tissues related to Prolactinoma:

34
Pituitary, Thyroid, Bone, Breast, Heart, Ovary, Testes, Brain, Colon, T cells, Prostate, Skin, Kidney, Spinal cord, Hypothalamus

Animal Models for Prolactinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Prolactinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.3POU1F1, PRL, MEN1, GHRHR, TRHR
2MP:00053878.3CNTF, GHRHR, MEN1, PRL, POU1F1
3MP:00053787.8AIP, POU1F1, SSTR5, MEN1, GHRHR, TRHR
4MP:00036317.5POU1F1, CHGB, PRL, MEN1, GHRHR, CNTF
5MP:00053797.4AIP, POU1F1, CHGB, PRL, SSTR5, MEN1
6MP:00053766.5TRHR, AIP, POU1F1, CHGB, PRL, SSTR5

Publications for Prolactinoma

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Sources:
53PubMed
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Articles related to Prolactinoma:

(show top 50)    (show all 577)
idTitleAuthorsYear
1
The prevalence and natural history of pituitary hemorrhage in prolactinoma. (23585661)
2013
2
Preclinical Atherosclerosis in Patients with Prolactinoma. (24325995)
2013
3
Prolactinoma ErbB receptor expression and targeted therapy for aggressive tumors. (24287797)
2013
4
Proptosis as the presenting sign of giant prolactinoma in a prepubertal boy: successful resolution of hydrocephalus by use of medical therapy. (23231524)
2012
5
Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-I^1 (TGF-I^1). (22700773)
2012
6
Optimization of transfection efficiency of small interfering RNA in purified human prolactinoma cells. (21740846)
2011
7
Insidious extension of pituitary prolactinoma: two can't-miss findings depicted on a 3.0-T MR system. (19453836)
2010
8
Inhibitory effects of anti-VEGF antibody on the growth and angiogenesis of estrogen-induced pituitary prolactinoma in Fischer 344 Rats: animal model of VEGF-targeted therapy for human endocrine tumors. (20514290)
2010
9
Proteomic analysis of prolactinoma cells by immuno-laser capture microdissection combined with online two-dimensional nano-scale liquid chromatography/mass spectrometry. (20205839)
2010
10
Prolactinomas, Cushing's disease and acromegaly: debating the role of medical therapy for secretory pituitary adenomas. (20478050)
2010
11
Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior. (20063113)
2010
12
An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region. (18846427)
2010
13
Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment. (19359408)
2009
14
Valvular heart disease and the use of cabergoline for the treatment of prolactinoma. (19128367)
2009
15
Hyperprolactinemia and prolactinomas. (18226731)
2008
16
Aortic valve calcification and mild tricuspid regurgitation but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma. (18559921)
2008
17
Effectiveness of long-term cabergoline treatment for giant prolactinoma: study of 12 men. (17287412)
2007
18
Inhibitory effect of thalidomide on the growth, secretory function and angiogenesis of estrogen-induced prolactinoma in Fischer 344 rats. (16846617)
2006
19
Metastatic prolactinoma: case report with immunohistochemical assessment for p53 and Ki-67 antigens. (16258673)
2005
20
Prevalence of osteopenia in men with prolactinoma. (15816365)
2005
21
Long-term efficacy of bromocriptine in macroprolactinomas and giant prolactinomas in men. (16379032)
2005
22
Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferentiation of gonadotroph to lactotroph cells in prolactinomas induced by estrogen. (15221415)
2004
23
Squash smear findings of spherical amyloid in pituitary prolactinoma. A case report. (15192968)
2004
24
First reported pediatric case of systemic lupus erythematosus associated with prolactinoma. (15529390)
2004
25
Long-term follow-up of prolactinomas: normoprolactinemia after bromocriptine withdrawal. (12161478)
2002
26
Prolactinomas: neurosurgical aspects]. (11965418)
2002
27
The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas. (10931080)
2000
28
Non-random trisomies of chromosomes 5, 8 and 12 in the prolactinoma sub-type of pituitary adenomas: conventional cytogenetics and interphase FISH study. (10760821)
2000
29
Prevalence of MEN 1 in patients with prolactinoma. MEN1 Study Group of the Hospital de la Santa Creu i Sant Pau of Barcelona. (10396374)
1999
30
Prolactinoma. (9174699)
1997
31
Prolactinoma presenting in identical twins with multiple endocrine neoplasia type 1. (8846498)
1996
32
The outcome of hypophysectomy for prolactinomas in the era of dopamine agonist therapy. (8759184)
1996
33
Medical therapy for prolactinomas and somatotroph adenomas. (15251513)
1996
34
Arrested puberty associated with apoplectic prolactinoma in a male adolescent. (7758013)
1995
35
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
36
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
37
Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. (8345693)
1993
38
Pituitary apoplexy in a patient with prolactinoma following computerized tomography scan. (1341487)
1992
39
Increased plasma VIP concentration in patients with prolactinoma. (1345563)
1992
40
Enlarged adenomectomy for enclosed prolactinomas: a preliminary study of 26 cases. (2399846)
1990
41
Human pituitary somatotroph adenoma and prolactinoma: an ultrastructural and immunoelectron microscopical study. (2213957)
1990
42
Estrogen-induced prolactinoma in a man. (3339116)
1988
43
Successful treatment of infertility in a man with a bromocriptine-resistant prolactinoma. (3117595)
1987
44
Pituitary-adrenocortical response to metoclopramide in patients with acromegaly and prolactinoma: a clinical evaluation of catecholamine-mediated adrenocorticotropin secretion. (3031125)
1987
45
Discordant responses of prolactinoma to two different dopamine agonists. (3742834)
1986
46
Transient intrasellar collection of air during bromocriptine treatment of a prolactinoma. (3762918)
1986
47
Subarachnoid metastases from a prolactinoma. (4080058)
1985
48
Galactorrhoea following hypophysectomy in a boy with a prolactinoma. (6540876)
1984
49
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. (6866052)
1983
50
Reversible "hypopituitarism" and disappearance of microadenoma in a prolactinoma patient treated with bromocriptine. (6653805)
1983

Variations for Prolactinoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Prolactinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1AIPNM_003977.2(AIP): c.40C> T (p.Gln14Ter)single nucleotide variantPathogenicrs104894194GRCh37Chr 11, 67250669: 67250669

Expression for genes affiliated with Prolactinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prolactinoma

Search GEO for disease gene expression data for Prolactinoma.

Pathways for genes affiliated with Prolactinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Compounds for genes affiliated with Prolactinoma

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46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 25HMDB, 52PharmGKB
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Compounds related to Prolactinoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1ghrp4610.1GHRHR, PRL
2lanreotide46 3011.1SSTR5, PRL
3hexarelin46 3011.1GHRHR, PRL
4clomiphene citrate469.8CGB, PRL
5bromocriptine46 30 1211.8POU1F1, PRL
6octreotide46 62 30 1212.7PRL, SSTR5
7silver469.7TRHR, GHRHR
8ribonucleic acid469.3POU1F1, PRL, SSTR5, GHRHR
9androstenedione46 2510.2CGB, PRL
10forskolin46 52 1211.1CNTF, GHRHR, POU1F1
11arginine469.0POU1F1, PRL, GHRHR, CNTF
12norepinephrine46 25 1211.0CNTF, PRL, CHGB
13thymidine46 2510.0POU1F1, SSTR5, MEN1, CNTF
14acth468.9POU1F1, CHGB, PRL, SSTR5
15progesterone46 30 62 25 1212.8POU1F1, PRL, CNTF, CGB
16cyclic amp46 259.8POU1F1, GHRHR, CNTF, CGB
17glucose468.7PRL, GHRHR, CNTF, CGB
18dexamethasone46 52 30 1211.7POU1F1, CHGB, PRL, GHRHR
19alanine468.6POU1F1, CNTF, TRHR, CGB
20dopamine46 30 25 1211.4CNTF, SSTR5, PRL, CHGB, POU1F1
21estrogen468.1CGB, MEN1, PRL, CHGB, POU1F1
22tyrosine468.0CNTF, MEN1, SSTR5, CHGB, POU1F1
23calcium46 52 25 1210.4POU1F1, CHGB, SSTR5, MEN1, GHRHR, CNTF

GO Terms for genes affiliated with Prolactinoma

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17Gene Ontology
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Cellular components related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear matrixGO:0163639.6GHRHR, MEN1
2secretory granuleGO:0301419.0GHRHR, CHGB

Biological processes related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatotropin secreting cell developmentGO:0601339.8GHRHR, POU1F1
2determination of adult lifespanGO:0083409.7GHRHR, POU1F1
3lactationGO:0075959.7PRL, GHRHR
4positive regulation of multicellular organism growthGO:0400189.6GHRHR, POU1F1
5positive regulation of cell proliferationGO:0082849.1CNTF, GHRHR, POU1F1
6negative regulation of cell proliferationGO:0082858.9MEN1, SSTR5, POU1F1

Molecular functions related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.7CGB, PRL, CHGB

Products for genes affiliated with Prolactinoma

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Sources for Prolactinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet