FIPA
MCID: PRL009
MIFTS: 64

Prolactinoma (FIPA) malady

Endocrine, Cancer, Gastrointestinal, Genetic categories

Summaries for Prolactinoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 A prolactinoma is a benign tumor (adenoma) of the pituitary gland that produces a hormone called... more...

MalaCards: Prolactinoma, also known as pituitary adenoma, prolactin-secreting, is related to adenoma and hyperprolactinemia. An important gene associated with Prolactinoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are GPCRs, Other and G alpha (q) signalling events. The compounds [125i]cgp 23996 and cgp 23996 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Description from OMIM:47 600634,102200

Aliases & Classifications for Prolactinoma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic
Anatomical: Endocrine, Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
familial isolated pituitary adenoma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

prolactinoma 8 45 49 61
pituitary adenoma, prolactin-secreting 8 9 47
prolactinoma, familial 43 22
prolactin-secreting pituitary adenoma 49
pituitary adenoma, familial isolated 61
familial isolated pituitary adenoma 49
multiple gastrointestinal atresias 61
prolactinoma of pituitary gland 8
prl-secreting pituitary adenoma 49
pituitary lactotrophic adenoma 49
familial prolactinoma 8
lactotroph adenoma 49
fipa 49


External Ids:

Disease Ontology8 DOID:5394
MeSH35 D015175
NCIt40 C3342
MESH via Orphanet36 D015175
ICD10 via Orphanet26 D35.2, E22.1
SNOMED-CT via Orphanet58 134209002, 34337008
UMLS via Orphanet62 C0033375

Related Diseases for Prolactinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Prolactinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.8DRD2, GNRHR, TRHR, AIP, SSTR3, SSTR4
2hyperprolactinemia30.7DRD2, PRL, TRH
3acromegaly30.6AIP, SSTR1, SSTR2, SSTR5, PRL, GHSR
4multiple endocrine neoplasia30.5MEN1, CHGB
5gigantism30.5AIP, PRL
6pituitary apoplexy30.4PRL, TRH
7pituitary tumors30.3PTTG1, FGF4, POU1F1, TRH, TRHR, AIP
8thyroiditis30.0TRH
9growth hormone deficiency30.0GHRHR, GHSR, PRL, POU1F1
10exophthalmos30.0TRH
11gastrinoma29.8SSTR1, SSTR2, SSTR5, MEN1
12glucagonoma29.8SSTR2, SSTR5, CHGB, MEN1
13empty sella syndrome29.8POU1F1, PRL
14adenocarcinoma29.8GNRHR, MEN1, CHGB, SSTR2, SSTR1, POU1F1
15familial isolated pituitary adenoma10.9
16aip-related familial isolated pituitary adenomas10.5
17headache10.3
18mixed cell adenoma10.3
19pseudotumor cerebri10.3
20growth hormone secreting pituitary adenoma10.3
21multiple intestinal atresia10.3
22familial meningioma10.2
23silent pituitary adenoma10.2
24gangliocytoma10.2
25systemic lupus erythematosus10.1
26adrenal adenoma10.1
27cluster headache10.1
28imperforate anus10.1
29autoimmune thyroiditis10.0
30schizoaffective disorder10.0
31gynecomastia10.0
32obstructive hydrocephalus10.0
33pathological gambling10.0
34osteoporosis10.0
35turner syndrome10.0
36sunct headache10.0
37sleep apnea10.0
38anovulation10.0PRL
39endogenous depression10.0TRH
40acth deficiency10.0POU1F1, PRL
41addison's disease10.0GNRHR
42anorexia nervosa10.0PRL
43craniopharyngioma10.0PRL, TRH
44hyperparathyroidism10.0MEN1
45colorectal cancer10.0PTTG1, SSTR2, DRD2
46pituitary hypoplasia10.0POU1F1, GHRHR
47hypopituitarism10.0POU1F1, TRH, PRL
48pancreatic islet cell tumors10.0MEN1
49gastroparesis10.0GHSR
50carney complex10.0AIP, MEN1

Graphical network of the top 20 diseases related to Prolactinoma:



Diseases related to prolactinoma

Clinical Features for Prolactinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

600634,102200

Clinical synopsis from OMIM:

600634

Drugs & Therapeutics for Prolactinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Prolactinoma

Drug clinical trials:

Search ClinicalTrials for Prolactinoma

Search NIH Clinical Center for Prolactinoma

Search CenterWatch for Prolactinoma

Genetic Tests for Prolactinoma

Sources:
22GTR
See all sources

Genetic tests related to Prolactinoma:

id Genetic test Affiliating Genes
1 Prolactinoma, Familial22

Anatomical Context for Prolactinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Prolactinoma:

33
Brain, Spinal cord, Heart, Small intestine, Colon, Kidney, Thyroid, Adrenal gland, Breast, Skin, Ovary, Prostate, T cells, B cells, Fetal brain, Hypothalamus, Fetal thyroid, Pituitary

Animal Models for Prolactinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Prolactinoma

Sources:
51PubMed
See all sources

Articles related to Prolactinoma:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
The first report of cabergoline-induced immune hemolytic anemia in an adolescent with prolactinoma. (23945126)
2014
2
A 22-year-old man with severe osteoporosis due to prolactinoma. (23965473)
2013
3
Prevalence of obstructive sleep apnea in patients with prolactinoma before and after treatment with dopamine agonists. (24068456)
2013
4
Rapidly progressing giant invasive prolactinoma. (22804858)
2012
5
Clinical Case Seminar. Peculiar prolactinomas in patients with pituitary developmental gene mutations: from an adult endocrinologist perspective. (22801565)
2012
6
Extracellular superoxide dismutase, a potential extracellular biomarker candidate for prolactinoma. (23620962)
2012
7
Epistaxis as first clinical presentation in a child with giant prolactinoma: Case report and review of literature. (22408665)
2011
8
Treating prolactinoma and psychosis: medication and cognitive behavioural therapy. (22715200)
2011
9
A man with 47,XYY karyotype, prolactinoma and a history of first trimester recurrent miscarriages in his wife. (21349809)
2011
10
Insidious extension of pituitary prolactinoma: two can't-miss findings depicted on a 3.0-T MR system. (19453836)
2010
11
Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior. (20063113)
2010
12
An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region. (18846427)
2010
13
Giant prolactinoma. (19289331)
2009
14
Low-dose cabergoline causing valvular heart disease in a patient treated for prolactinoma. (19402868)
2009
15
Case report: Unusual orbital invasion by a giant prolactinoma. (18941037)
2008
16
Difficulties in the medical treatment of prolactinoma in a patient with schizophrenia--a case report with a review of the literature. (18204364)
2008
17
Effectiveness of long-term cabergoline treatment for giant prolactinoma: study of 12 men. (17287412)
2007
18
Decreased bone mineral density in pre-menopause women with prolactinoma]. (18209896)
2007
19
Clinical and histological correlations in prolactinomas, with special reference to bromocriptine resistance. (15971099)
2005
20
Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 hours in the GH3 prolactinoma rat tumor model. (15140404)
2004
21
Salmon roe-like amyloid deposition in a prolactinoma: a case report. (14756447)
2003
22
Blurred vision during airline flight reveals prolactinoma. (12645849)
2003
23
Histochemical and immunohistochemical features of a case showing association of meningioma and prolactinoma containing amyloid. (12455881)
2002
24
Prolactinomas in children and adolescents--consequences in adult life. (11964017)
2001
25
Comparative immunohistochemical analysis of estrogen receptor and chromogranin-A reactivity in plurihormonal human prolactinomas. (11028110)
2000
26
Malignant prolactinoma discovered by D2 receptor imaging. (10634416)
2000
27
Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up. (9709946)
1998
28
Effect of surgery on gonadal function of premenopausal women with pituitary adenomas other than prolactinomas. (8793326)
1996
29
Prolactinomas resistant to bromocriptine: long-term efficacy of quinagolide and outcome of pregnancy. (8921822)
1996
30
Inhibitory effects of fumagillin and its analogue TNP-470 on the function, morphology and angiogenesis of an oestrogen-induced prolactinoma in Fischer 344 rats. (8708569)
1996
31
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
32
Treatment of prolactinoma patients with the new non-ergot dopamine agonist roxindol: first results. (7950157)
1994
33
Mapping the gene for hereditary hyperparathyroidism and prolactinoma (MEN1Burin) to chromosome 11q: evidence for a founder effect in patients from Newfoundland. (7911003)
1994
34
Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. (8345693)
1993
35
Advances in diagnostic techniques of pituitary tumors and prolactinomas. (1591282)
1992
36
Intracranial calcification and brachydactyly mimicking Albright's hereditary osteodystrophy in an adult patient with lingual thyroid and prolactinoma-like lesion. (1678415)
1991
37
Prolactinoma in a middle-aged man with an osteoporotic fracture. (2763547)
1989
38
Influence of pergolide treatment on xenotransplanted human pituitary tumors of prolactinoma. (2749497)
1989
39
Ileal carcinoid tumor complicated by retroperitoneal fibrosis and a prolactinoma. (2899975)
1988
40
Dopaminergic effects on kidney function and responsiveness of aldosterone, plasma renin activity, prolactin, catecholamines, and blood pressure to stimulation in patients with prolactinoma. Comparison of the efficacy of pergolide and bromocriptine therapy. (3285838)
1988
41
Visual function in prolactinoma patients treated with bromocriptine. (4069600)
1985
42
Immunofluorescence demonstration of tubulin and actin in estrogen-induced rat prolactinoma cells in vitro. Alteration of their distribution after bromocriptine, colchicine and cytochalasin B treatments. (3905419)
1985
43
Acute psychosis secondary to bromocriptine treatment in a patient with a prolactinoma. (6484333)
1984
44
Postoperative evaluation of dopaminergic tone in prolactinoma patients. II. Plasma thyrotropin response to metoclopramide. (6693543)
1984
45
Pituitary function in 20 cases of prolactinoma in females. (6408728)
1983
46
Prolactinoma in a man following industrial exposure to estrogens. (6880188)
1983
47
Prolactinoma. (7070625)
1982
48
Rapid changes of prolactinoma volume after withdrawal and reinstitution of bromocriptine. (7263835)
1981
49
Bromocriptine reduction of prolactinoma size. (7308514)
1981
50
Calcified pituitary prolactinoma. (6787486)
1981

Genetic Variations for Prolactinoma

Expression for genes affiliated with Prolactinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Prolactinoma

Search GEO for disease gene expression data for Prolactinoma.

Pathways for genes affiliated with Prolactinoma

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Prolactinoma

Sources:
29IUPHAR, 45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Prolactinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1[125i]cgp 239962910.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
2cgp 239962910.8SSTR4, SSTR1, SSTR2, SSTR5, SSTR3
3ke 1082910.8SSTR2, SSTR3, SSTR4, SSTR1, SSTR5
4[125i]tyr10-cst142910.8SSTR5, SSTR2, SSTR3, SSTR4, SSTR1
5srif-142910.8SSTR5, SSTR3, SSTR4, SSTR1, SSTR2
6cst-172910.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
7bim 230522910.8SSTR2, SSTR4, SSTR5, SSTR1, SSTR3
8srif-282910.8SSTR3, SSTR1, SSTR2, SSTR5, SSTR4
9estrogen4510.8PTTG1, TRH
10[125i]ltt-srif-282910.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
11[d-tyr8]cyn 1548062910.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
12bim 234542910.7SSTR1, SSTR4, SSTR3, SSTR2, SSTR5
13bim 236272910.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
14l-362,8552910.7SSTR5, SSTR1, SSTR4, SSTR2, SSTR3
15lanreotide45 2911.7PRL, GHSR, SSTR5, SSTR2, SSTR1, SSTR3
16som-2302910.7SSTR5, SSTR2, SSTR3, SSTR1
17[l-tyr8]cyn 1548062910.7SSTR3, SSTR2, SSTR1, SSTR4, SSTR5
18cst-142910.7SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
19cyclosomatostatin6010.7SSTR5, SSTR3, SSTR4, SSTR2, SSTR1
20pasireotide45 1111.7SSTR3, SSTR1, SSTR2, SSTR5
21(1r,1s,3r/1r,1r,3s)-l-054,2646010.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
22vapreotide29 45 1112.7GHSR, SSTR3, SSTR2, SSTR5, CORT
23cyn 1548066010.7SSTR2, SSTR1, SSTR4, SSTR3, SSTR5
24des-aa5-[d-trp8]srif2910.7SSTR5, SSTR4, SSTR3, SSTR1
25somatostatin60 2411.7SSTR5, SSTR4, SSTR1, SSTR2, SSTR3
26ghrp4510.7TRH, GHRHR, GHSR, PRL
27bromocriptine29 45 1112.7POU1F1, GNRHR, PRL, TRH
28bim 230562910.7SSTR2, SSTR5, SSTR3
29hexarelin45 2911.7GHSR, PRL, GHRHR, CORT
30l-363,3012910.7SSTR5, SSTR2, SSTR3
31ribonucleic acid4510.7GNRHR, SSTR5, GHSR, PRL, SSTR2, SSTR1
32bim 230232910.7SSTR5, SSTR2, SSTR3
33dopamine45 29 11 2413.6GNRHR, DRD2, PTTG1, NGFR, TRH, SSTR1
34acth4510.6GHSR, TRH, SSTR2, CHGB, CORT, POU1F1
35octreotide45 60 29 1113.6CORT, DRD2, GHSR, PRL, SSTR2, SSTR1
36prl-29152910.6SSTR3, SSTR5, SSTR4
37[111in,90y]dota-noc2910.6SSTR5, SSTR2, SSTR3
38[111in]dota-noc-ate2910.6SSTR5, SSTR3, SSTR2
39thymidine45 2411.6NGFR, GNRHR, MEN1, SSTR2, POU1F1, SSTR5
40boc-ate2910.6SSTR5, SSTR2, SSTR3
41adenylate4510.5GNRHR, DRD2, GHRHR, TRH, SSTR1, SSTR2
42bim 230682910.5SSTR3, SSTR4, SSTR2
43nc 4-28b2910.5SSTR2, SSTR1, SSTR3
44tyrosine4510.5FGF4, NGFR, POU1F1, TRH, SSTR4, SSTR1
45[111in]dota-noc2910.5SSTR5, SSTR2, SSTR3
46calcium45 50 11 2413.5MEN1, PTTG1, TRH, TRHR, SSTR1, SSTR2
47[111in]dota-boc-ate2910.4SSTR5, SSTR2, SSTR3
48bim 230502910.4SSTR5, SSTR1, SSTR3
49[111in,90y]dota-oc2910.3SSTR5, SSTR2, SSTR3
50bim 231972910.1SSTR5, SSTR2, SSTR3

GO Terms for genes affiliated with Prolactinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.4TRH, CHGB, PRL, GHRHR
2integral to plasma membraneGO:00588710.1NGFR, GNRHR, DRD2, SSTR5, SSTR2, SSTR1
3plasma membraneGO:0058869.8SSTR5, GHSR, GHRHR, DRD2, GNRHR, SSTR2

Biological processes related to Prolactinoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of multicellular organism growthGO:04001810.7DRD2, GHRHR, GHSR, POU1F1
2cellular response to glucocorticoid stimulusGO:07138510.7SSTR3, SSTR4, SSTR2
3cellular response to estradiol stimulusGO:07139210.7SSTR2, SSTR1, SSTR3
4somatostatin signaling pathwayGO:03817010.7SSTR3, SSTR5
5somatotropin secreting cell developmentGO:06013310.7POU1F1, GHRHR
6forebrain developmentGO:03090010.7SSTR2, SSTR1, SSTR4, SSTR3
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
8cerebellum developmentGO:02154910.7SSTR2, SSTR1, SSTR3
9response to starvationGO:04259410.6SSTR2, SSTR1, SSTR3
10negative regulation of cell proliferationGO:00828510.6POU1F1, DRD2, MEN1, SSTR5, SSTR2, SSTR1
11cell-cell signalingGO:00726710.6FGF4, TRH, SSTR3, SSTR1, SSTR2
12response to nutrientGO:00758410.6SSTR1, SSTR2, PRL
13positive regulation of growth hormone secretionGO:06012410.6DRD2, GHRHR
14peristalsisGO:03043210.5DRD2, SSTR2
15G-protein coupled receptor signaling pathwayGO:00718610.5GNRHR, GHSR, SSTR5, SSTR4, TRHR
16growth hormone secretionGO:03025210.5GHRHR, GHSR
17positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.4GHRHR, GHSR
18hormone-mediated signaling pathwayGO:00975510.4TRH, GHSR
19determination of adult lifespanGO:00834010.3GHRHR, POU1F1
20spermatogenesisGO:00728310.1PTTG1, SSTR3, SSTR1, SSTR2

Molecular functions related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth hormone-releasing hormone receptor activityGO:01652010.4GHSR, GHRHR
2somatostatin receptor activityGO:00499410.0SSTR3, SSTR4, SSTR1, SSTR2, SSTR5

Products for genes affiliated with Prolactinoma

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  • Antibodies

Sources for Prolactinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet