MCID: PRL009
MIFTS: 63

Prolactinoma malady

Genetic diseases, Rare diseases, Reproductive diseases, Endocrine diseases, Cancer diseases categories
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Summaries for Prolactinoma

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Wikipedia:65 A prolactinoma is a benign tumor (adenoma) of the pituitary gland that produces a hormone called... more...

MalaCards based summary: Prolactinoma, also known as pituitary adenoma, prolactin-secreting, is related to pituitary apoplexy and hyperprolactinemia, and has symptoms including An important gene associated with Prolactinoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Glucocorticoid receptor regulatory network and Peptide ligand-binding receptors. The compounds ghrp and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and thyroid, and related mouse phenotypes are reproductive system and immune system.

Description from OMIM:46 600634

Aliases & Classifications for Prolactinoma

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Prolactinoma, Aliases & Descriptions:

Name: Prolactinoma 8 44 48 62
Pituitary Adenoma, Prolactin-Secreting 8 9 46 62
Prolactinoma, Familial 42 22 62
Prl-Secreting Pituitary Adenoma 48 62
Prolactinoma of Pituitary Gland 8 62
 
Lactotroph Adenoma 48 62
Prolactin-Secreting Pituitary Adenoma 48
Pituitary Lactotrophic Adenoma 48
Familial Prolactinoma 8
Prloma 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
prolactinoma:
Prevalence: 6-9/10000; Age of onset: Adolescence / Young adulthood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:5394
MeSH34 D015175
OMIM46 600634
NCIt39 C3342
MESH via Orphanet35 D015175
ICD10 via Orphanet26 D35.2, E22.1
UMLS via Orphanet63 C0033375

Related Diseases for Prolactinoma

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Diseases related to Prolactinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary apoplexy31.2PRL
2hyperprolactinemia31.1CGB, PRL
3gigantism31.0AIP, PRL
4psychotic disorder30.8CNTF, PRL
5multiple endocrine neoplasia30.5CHGB, MEN1
6hypogonadism30.5PRL, POU1F1
7empty sella syndrome30.3PRL, POU1F1
8growth hormone deficiency30.3POU1F1, GHRHR, PRL
9gastrinoma30.2MEN1, SSTR5
10schizophrenia29.8CHGB, CNTF, PRL
11glucagonoma29.7MEN1, SSTR5, CHGB
12acromegaly29.7CGB, TRHR, GHRHR, MEN1, AIP, PRL
13breast cancer29.3SSTR5, GHRHR, CGB, MEN1, POU1F1, PRL
14pituitary tumors29.3TRHR, PRL, GHRHR, MEN1, SSTR5, CHGB
15adenocarcinoma29.1POU1F1, CHGB, MEN1, CGB
16adenoma29.1TRHR, AIP, POU1F1, CHGB, PRL, SSTR5
17pituitary adenoma28.9GHRHR, MEN1, SSTR5, PRL, CHGB, POU1F1
18somatostatin analog10.5
19growth hormone secreting pituitary adenoma10.3
20pseudotumor cerebri10.3
21headache10.3
22thyrotropin deficiency, isolated10.3PRL, POU1F1
23panhypopituitarism10.3POU1F1, PRL
24pituitary hypoplasia10.3POU1F1, GHRHR
25acth deficiency10.3POU1F1, PRL
26pituitary gland disease10.3MEN1, PRL
27hormone producing pituitary cancer10.3AIP, MEN1
28hypopituitarism10.3POU1F1, PRL
29hydrocephalus10.2
30thyroiditis10.2
31carney complex10.2MEN1, AIP
32wermer syndrome10.2MEN1, AIP
33dwarfism10.2GHRHR, POU1F1
34gangliocytoma10.2
35klinefelter's syndrome10.2PRL, CGB
36short stature10.1GHRHR, PRL, POU1F1
37cushing's syndrome10.1MEN1, PRL
38systemic lupus erythematosus10.1
39transsexualism10.1
40cervicitis10.1
41hyperparathyroidism10.1
42lupus erythematosus10.1
43meningioma10.1
44meningitis10.1
45pancreatitis10.1
46pituitary carcinoma10.1
47aneurysm10.1
48serotonin syndrome10.1MEN1, CGB
49insulinoma10.1MEN1, SSTR5
50hyperthyroidism10.1PRL, TRHR, CGB

Graphical network of the top 20 diseases related to Prolactinoma:



Diseases related to prolactinoma

Symptoms for Prolactinoma

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Symptoms by clinical synopsis from OMIM:

600634

Clinical features from OMIM:

600634

HPO human phenotypes related to Prolactinoma:

id Description Frequency HPO Source Accession
1 pituitary prolactin cell adenoma HP:0006767

Drugs & Therapeutics for Prolactinoma

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Drug clinical trials:

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Search NIH Clinical Center for Prolactinoma

Genetic Tests for Prolactinoma

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Genetic tests related to Prolactinoma:

id Genetic test Affiliating Genes
1 Prolactinoma, Familial22

Anatomical Context for Prolactinoma

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MalaCards organs/tissues related to Prolactinoma:

32
Pituitary, Bone, Thyroid, Brain, Breast, Heart, Ovary, Testes, Colon, Spinal cord, Kidney, Skin, Prostate, T cells, Hypothalamus

Animal Models for Prolactinoma or affiliated genes

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MGI Mouse Phenotypes related to Prolactinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.3POU1F1, PRL, MEN1, GHRHR, TRHR
2MP:00053878.3CNTF, GHRHR, MEN1, PRL, POU1F1
3MP:00053787.8AIP, POU1F1, SSTR5, MEN1, GHRHR, TRHR
4MP:00036317.5POU1F1, CHGB, PRL, MEN1, GHRHR, CNTF
5MP:00053797.4AIP, POU1F1, CHGB, PRL, SSTR5, MEN1
6MP:00053766.5TRHR, AIP, POU1F1, CHGB, PRL, SSTR5

Publications for Prolactinoma

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Articles related to Prolactinoma:

(show top 50)    (show all 600)
idTitleAuthorsYear
1
A case of pediatric atypical prolactinoma: significance of a multidisciplinary treatment approach. (25048518)
2014
2
Endoscopic transsphenoidal treatment of a prolactinoma patient with brain and optic chiasmal herniations. (24820730)
2014
3
Giant prolactinoma presenting as a skull base tumor with erosion of the cervical vertebrae: pronounced responsiveness to dopamine agonist treatment. (25162753)
2014
4
Preclinical Atherosclerosis in Patients with Prolactinoma. (24325995)
2013
5
Prolactinoma ErbB receptor expression and targeted therapy for aggressive tumors. (24287797)
2013
6
The expression of AIB1 correlates with cellular proliferation in human prolactinomas. (23433587)
2013
7
Proptosis as the presenting sign of giant prolactinoma in a prepubertal boy: successful resolution of hydrocephalus by use of medical therapy. (23231524)
2012
8
Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-I^1 (TGF-I^1). (22700773)
2012
9
Insidious extension of pituitary prolactinoma: two can't-miss findings depicted on a 3.0-T MR system. (19453836)
2010
10
Inhibitory effects of anti-VEGF antibody on the growth and angiogenesis of estrogen-induced pituitary prolactinoma in Fischer 344 Rats: animal model of VEGF-targeted therapy for human endocrine tumors. (20514290)
2010
11
Proteomic analysis of prolactinoma cells by immuno-laser capture microdissection combined with online two-dimensional nano-scale liquid chromatography/mass spectrometry. (20205839)
2010
12
Prolactinomas, Cushing's disease and acromegaly: debating the role of medical therapy for secretory pituitary adenomas. (20478050)
2010
13
Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior. (20063113)
2010
14
An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region. (18846427)
2010
15
Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment. (19359408)
2009
16
Valvular heart disease and the use of cabergoline for the treatment of prolactinoma. (19128367)
2009
17
Hyperprolactinemia and prolactinomas. (18226731)
2008
18
Aortic valve calcification and mild tricuspid regurgitation but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma. (18559921)
2008
19
Effectiveness of long-term cabergoline treatment for giant prolactinoma: study of 12 men. (17287412)
2007
20
Inhibitory effect of thalidomide on the growth, secretory function and angiogenesis of estrogen-induced prolactinoma in Fischer 344 rats. (16846617)
2006
21
Metastatic prolactinoma: case report with immunohistochemical assessment for p53 and Ki-67 antigens. (16258673)
2005
22
Prevalence of osteopenia in men with prolactinoma. (15816365)
2005
23
Long-term efficacy of bromocriptine in macroprolactinomas and giant prolactinomas in men. (16379032)
2005
24
Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferentiation of gonadotroph to lactotroph cells in prolactinomas induced by estrogen. (15221415)
2004
25
Squash smear findings of spherical amyloid in pituitary prolactinoma. A case report. (15192968)
2004
26
First reported pediatric case of systemic lupus erythematosus associated with prolactinoma. (15529390)
2004
27
Long-term follow-up of prolactinomas: normoprolactinemia after bromocriptine withdrawal. (12161478)
2002
28
Prolactinomas: neurosurgical aspects]. (11965418)
2002
29
The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas. (10931080)
2000
30
Non-random trisomies of chromosomes 5, 8 and 12 in the prolactinoma sub-type of pituitary adenomas: conventional cytogenetics and interphase FISH study. (10760821)
2000
31
Prevalence of MEN 1 in patients with prolactinoma. MEN1 Study Group of the Hospital de la Santa Creu i Sant Pau of Barcelona. (10396374)
1999
32
Prolactinoma. (9174699)
1997
33
Prolactinoma presenting in identical twins with multiple endocrine neoplasia type 1. (8846498)
1996
34
The outcome of hypophysectomy for prolactinomas in the era of dopamine agonist therapy. (8759184)
1996
35
Arrested puberty associated with apoplectic prolactinoma in a male adolescent. (7758013)
1995
36
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
37
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
38
Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. (8345693)
1993
39
Pituitary apoplexy in a patient with prolactinoma following computerized tomography scan. (1341487)
1992
40
Enlarged adenomectomy for enclosed prolactinomas: a preliminary study of 26 cases. (2399846)
1990
41
Human pituitary somatotroph adenoma and prolactinoma: an ultrastructural and immunoelectron microscopical study. (2213957)
1990
42
Estrogen-induced prolactinoma in a man. (3339116)
1988
43
Successful treatment of infertility in a man with a bromocriptine-resistant prolactinoma. (3117595)
1987
44
Pituitary-adrenocortical response to metoclopramide in patients with acromegaly and prolactinoma: a clinical evaluation of catecholamine-mediated adrenocorticotropin secretion. (3031125)
1987
45
Discordant responses of prolactinoma to two different dopamine agonists. (3742834)
1986
46
Transient intrasellar collection of air during bromocriptine treatment of a prolactinoma. (3762918)
1986
47
Subarachnoid metastases from a prolactinoma. (4080058)
1985
48
Galactorrhoea following hypophysectomy in a boy with a prolactinoma. (6540876)
1984
49
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. (6866052)
1983
50
Reversible "hypopituitarism" and disappearance of microadenoma in a prolactinoma patient treated with bromocriptine. (6653805)
1983

Variations for Prolactinoma

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Clinvar genetic disease variations for Prolactinoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1AIPNM_003977.2(AIP): c.40C> T (p.Gln14Ter)single nucleotide variantPathogenicrs104894194GRCh37Chr 11, 67250669: 67250669

Expression for genes affiliated with Prolactinoma

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Expression patterns in normal tissues for genes affiliated with Prolactinoma

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Pathways for genes affiliated with Prolactinoma

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Compounds for genes affiliated with Prolactinoma

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Compounds related to Prolactinoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1ghrp4410.1GHRHR, PRL
2lanreotide44 2811.1PRL, SSTR5
3hexarelin44 2811.1PRL, GHRHR
4clomiphene citrate449.8PRL, CGB
5bromocriptine44 28 1111.8PRL, POU1F1
6octreotide44 61 28 1112.7SSTR5, PRL
7androstenedione44 2410.5CGB, PRL
8silver449.4TRHR, GHRHR
9ribonucleic acid449.3GHRHR, POU1F1, SSTR5, PRL
10forskolin44 50 1111.1POU1F1, GHRHR, CNTF
11arginine449.0POU1F1, CNTF, PRL, GHRHR
12norepinephrine44 24 1111.0PRL, CNTF, CHGB
13thymidine44 2410.0SSTR5, MEN1, CNTF, POU1F1
14acth448.9POU1F1, SSTR5, PRL, CHGB
15progesterone44 28 61 24 1112.8PRL, CNTF, CGB, POU1F1
16cyclic amp44 249.8GHRHR, POU1F1, CNTF, CGB
17glucose448.7CGB, PRL, CNTF, GHRHR
18dexamethasone44 50 28 1111.7GHRHR, POU1F1, PRL, CHGB
19alanine448.6CGB, TRHR, CNTF, POU1F1
20dopamine44 28 24 1111.4PRL, CHGB, SSTR5, CNTF, POU1F1
21estrogen448.1POU1F1, PRL, CGB, MEN1, CHGB
22tyrosine448.0SSTR5, MEN1, CNTF, POU1F1, CHGB
23calcium44 50 24 1110.4CNTF, GHRHR, MEN1, TRHR, SSTR5, CHGB

GO Terms for genes affiliated with Prolactinoma

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Cellular components related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear matrixGO:0163639.6GHRHR, MEN1
2secretory granuleGO:0301419.0GHRHR, CHGB

Biological processes related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatotropin secreting cell developmentGO:0601339.8GHRHR, POU1F1
2determination of adult lifespanGO:0083409.7GHRHR, POU1F1
3lactationGO:0075959.7PRL, GHRHR
4positive regulation of multicellular organism growthGO:0400189.6GHRHR, POU1F1
5positive regulation of cell proliferationGO:0082849.1CNTF, GHRHR, POU1F1
6negative regulation of cell proliferationGO:0082858.9MEN1, SSTR5, POU1F1

Molecular functions related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.7CGB, PRL, CHGB

Products for genes affiliated with Prolactinoma

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Sources for Prolactinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet