MCID: PRL009
MIFTS: 50

Prolactinoma malady

Genetic diseases, Rare diseases, Reproductive diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Prolactinoma

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Sources:
9Disease Ontology, 43Novoseek, 47Orphanet, 60UMLS, 41NIH Rare Diseases, 22GTR, 55SNOMED-CT, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Prolactinoma, Aliases & Descriptions:

Name: Prolactinoma 9 43 47 60
Prolactinoma, Familial 41 22
Pituitary Adenoma, Prolactin-Secreting 9
Prolactin-Secreting Pituitary Adenoma 47
Prl-Secreting Pituitary Adenoma 47
 
Prolactinoma of Pituitary Gland 9
Pituitary Lactotrophic Adenoma 47
Familial Prolactinoma 9
Lactotroph Adenoma 47
Prloma 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
prolactinoma:
Prevalence: 1-5/10000 (United Kingdom),6-9/10000 (Belgium),1-5/10000 (Switzerland),1-9/100000 (Malta); Age of onset: Adolescent,Adult,Childhood,Elderly; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:5394
MeSH33 D015175
NCIt38 C3342
Orphanet47 2965
MESH via Orphanet34 D015175
ICD10 via Orphanet26 D35.2, E22.1
UMLS via Orphanet61 C0033375

Summaries for Prolactinoma

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Wikipedia:63 A prolactinoma is a benign tumor (adenoma) of the pituitary gland that produces a hormone called... more...

MalaCards based summary: Prolactinoma, also known as prolactinoma, familial, is related to pituitary apoplexy and hyperprolactinemia. An important gene associated with Prolactinoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Glucocorticoid receptor regulatory network and Peptide ligand-binding receptors. The compounds ghrp and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and thyroid, and related mouse phenotypes are reproductive system and immune system.

Related Diseases for Prolactinoma

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Diseases related to Prolactinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary apoplexy31.2PRL
2hyperprolactinemia31.0CGB, PRL
3gigantism31.0AIP, PRL
4psychotic disorder30.7CNTF, PRL
5multiple endocrine neoplasia30.5CHGB, MEN1
6hypogonadism30.5PRL, POU1F1
7empty sella syndrome30.3PRL, POU1F1
8growth hormone deficiency30.3POU1F1, GHRHR, PRL
9gastrinoma30.2MEN1, SSTR5
10adenocarcinoma29.8POU1F1, CHGB, MEN1, CGB
11schizophrenia29.7CHGB, CNTF, PRL
12glucagonoma29.7MEN1, SSTR5, CHGB
13acromegaly29.7CGB, TRHR, GHRHR, MEN1, AIP, PRL
14breast cancer29.3SSTR5, GHRHR, CGB, MEN1, POU1F1, PRL
15pituitary tumors29.2TRHR, PRL, GHRHR, MEN1, SSTR5, CHGB
16adenoma29.1TRHR, AIP, POU1F1, CHGB, PRL, SSTR5
17pituitary adenoma28.9GHRHR, MEN1, SSTR5, PRL, CHGB, POU1F1
18pseudotumor cerebri10.4
19headache10.3
20hypothryoidism, congenital, nongoitrous 410.3PRL, POU1F1
21pituitary hormone deficiency, combined, 210.3POU1F1, PRL
22pituitary hypoplasia10.3POU1F1, GHRHR
23acth deficiency10.3POU1F1, PRL
24pituitary gland disease10.3MEN1, PRL
25hormone producing pituitary cancer10.3AIP, MEN1
26hypopituitarism10.2POU1F1, PRL
27hydrocephalus10.2
28thyroiditis10.2
29carney complex variant10.2MEN1, AIP
30multiple endocrine neoplasia 110.2MEN1, AIP
31dwarfism10.2GHRHR, POU1F1
32gangliocytoma10.2
33klinefelter's syndrome10.1PRL, CGB
34systemic lupus erythematosus10.1
35transsexualism10.1
36cervicitis10.1
37hyperparathyroidism10.1
38lupus erythematosus10.1
39mastitis10.1
40meningitis10.1
41pancreatitis10.1
42pituitary carcinoma10.1
43aneurysm10.1
44granulomatous mastitis10.1
45cushing's syndrome10.1MEN1, PRL
46serotonin syndrome10.1MEN1, CGB
47insulinoma10.1MEN1, SSTR5
48hyperthyroidism10.1PRL, TRHR, CGB
49osteoporosis10.0
50pituitary adenoma, prolactin-secreting10.0

Graphical network of the top 20 diseases related to Prolactinoma:



Diseases related to prolactinoma

Symptoms for Prolactinoma

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Drugs & Therapeutics for Prolactinoma

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Drug clinical trials:

Search ClinicalTrials for Prolactinoma

Search NIH Clinical Center for Prolactinoma

Genetic Tests for Prolactinoma

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Genetic tests related to Prolactinoma:

id Genetic test Affiliating Genes
1 Prolactinoma, Familial22

Anatomical Context for Prolactinoma

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MalaCards organs/tissues related to Prolactinoma:

31
Pituitary, Bone, Thyroid, Brain, Breast, Heart, Ovary, Testes, Colon, Spinal cord, Kidney, Skin, Prostate, T cells, Hypothalamus

Animal Models for Prolactinoma or affiliated genes

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MGI Mouse Phenotypes related to Prolactinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.3POU1F1, PRL, MEN1, GHRHR, TRHR
2MP:00053878.3CNTF, GHRHR, MEN1, PRL, POU1F1
3MP:00053787.8AIP, POU1F1, SSTR5, MEN1, GHRHR, TRHR
4MP:00036317.5POU1F1, CHGB, PRL, MEN1, GHRHR, CNTF
5MP:00053797.4AIP, POU1F1, CHGB, PRL, SSTR5, MEN1
6MP:00053766.5TRHR, AIP, POU1F1, CHGB, PRL, SSTR5

Publications for Prolactinoma

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Articles related to Prolactinoma:

(show top 50)    (show all 621)
idTitleAuthorsYear
1
ENDOCRINOLOGY IN PREGNANCY: Management of the pregnant patient with a prolactinoma. (25805896)
2015
2
A case of pediatric atypical prolactinoma: significance of a multidisciplinary treatment approach. (25048518)
2014
3
Endoscopic transsphenoidal treatment of a prolactinoma patient with brain and optic chiasmal herniations. (24820730)
2014
4
The need for annual echocardiography to detect cabergoline-associated valvulopathy in patients with prolactinoma: a systematic review and additional clinical data. (25466526)
2014
5
Differential effects of estrogen and estrogen receptor antagonist, ICI 182 780, on the expression of calbindin-D9k in rat pituitary prolactinoma GHa88 cells. (25674214)
2014
6
The prevalence and natural history of pituitary hemorrhage in prolactinoma. (23585661)
2013
7
Preclinical Atherosclerosis in Patients with Prolactinoma. (24325995)
2013
8
Prolactinoma ErbB receptor expression and targeted therapy for aggressive tumors. (24287797)
2013
9
The expression of AIB1 correlates with cellular proliferation in human prolactinomas. (23433587)
2013
10
Proptosis as the presenting sign of giant prolactinoma in a prepubertal boy: successful resolution of hydrocephalus by use of medical therapy. (23231524)
2012
11
Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-I^1 (TGF-I^1). (22700773)
2012
12
Insidious extension of pituitary prolactinoma: two can't-miss findings depicted on a 3.0-T MR system. (19453836)
2010
13
Inhibitory effects of anti-VEGF antibody on the growth and angiogenesis of estrogen-induced pituitary prolactinoma in Fischer 344 Rats: animal model of VEGF-targeted therapy for human endocrine tumors. (20514290)
2010
14
Proteomic analysis of prolactinoma cells by immuno-laser capture microdissection combined with online two-dimensional nano-scale liquid chromatography/mass spectrometry. (20205839)
2010
15
Prolactinomas, Cushing's disease and acromegaly: debating the role of medical therapy for secretory pituitary adenomas. (20478050)
2010
16
Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior. (20063113)
2010
17
An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region. (18846427)
2010
18
Recovery of persistent hypogonadism by clomiphene in males with prolactinomas under dopamine agonist treatment. (19359408)
2009
19
Valvular heart disease and the use of cabergoline for the treatment of prolactinoma. (19128367)
2009
20
Hyperprolactinemia and prolactinomas. (18226731)
2008
21
Aortic valve calcification and mild tricuspid regurgitation but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma. (18559921)
2008
22
Effectiveness of long-term cabergoline treatment for giant prolactinoma: study of 12 men. (17287412)
2007
23
Metastatic prolactinoma: case report with immunohistochemical assessment for p53 and Ki-67 antigens. (16258673)
2005
24
Prevalence of osteopenia in men with prolactinoma. (15816365)
2005
25
Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferentiation of gonadotroph to lactotroph cells in prolactinomas induced by estrogen. (15221415)
2004
26
Squash smear findings of spherical amyloid in pituitary prolactinoma. A case report. (15192968)
2004
27
Long-term follow-up of prolactinomas: normoprolactinemia after bromocriptine withdrawal. (12161478)
2002
28
Prolactinomas: neurosurgical aspects]. (11965418)
2002
29
The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas. (10931080)
2000
30
Non-random trisomies of chromosomes 5, 8 and 12 in the prolactinoma sub-type of pituitary adenomas: conventional cytogenetics and interphase FISH study. (10760821)
2000
31
Prevalence of MEN 1 in patients with prolactinoma. MEN1 Study Group of the Hospital de la Santa Creu i Sant Pau of Barcelona. (10396374)
1999
32
Prolactinoma. (9174699)
1997
33
Prolactinoma presenting in identical twins with multiple endocrine neoplasia type 1. (8846498)
1996
34
The outcome of hypophysectomy for prolactinomas in the era of dopamine agonist therapy. (8759184)
1996
35
Arrested puberty associated with apoplectic prolactinoma in a male adolescent. (7758013)
1995
36
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
37
Anomalous growth hormone response to vasoactive intestinal peptide and peptide histidine methionine in patients with prolactinoma or hypothalamic hyperprolactinemia. (7991068)
1994
38
Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. (8345693)
1993
39
Pituitary apoplexy in a patient with prolactinoma following computerized tomography scan. (1341487)
1992
40
Enlarged adenomectomy for enclosed prolactinomas: a preliminary study of 26 cases. (2399846)
1990
41
Human pituitary somatotroph adenoma and prolactinoma: an ultrastructural and immunoelectron microscopical study. (2213957)
1990
42
Estrogen-induced prolactinoma in a man. (3339116)
1988
43
Successful treatment of infertility in a man with a bromocriptine-resistant prolactinoma. (3117595)
1987
44
Pituitary-adrenocortical response to metoclopramide in patients with acromegaly and prolactinoma: a clinical evaluation of catecholamine-mediated adrenocorticotropin secretion. (3031125)
1987
45
Discordant responses of prolactinoma to two different dopamine agonists. (3742834)
1986
46
Transient intrasellar collection of air during bromocriptine treatment of a prolactinoma. (3762918)
1986
47
Subarachnoid metastases from a prolactinoma. (4080058)
1985
48
Galactorrhoea following hypophysectomy in a boy with a prolactinoma. (6540876)
1984
49
Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. (6866052)
1983
50
Reversible "hypopituitarism" and disappearance of microadenoma in a prolactinoma patient treated with bromocriptine. (6653805)
1983

Variations for Prolactinoma

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Clinvar genetic disease variations for Prolactinoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1AIPNM_003977.2(AIP): c.40C> T (p.Gln14Ter)single nucleotide variantPathogenicrs104894194GRCh37Chr 11, 67250669: 67250669

Cosmic variations for Prolactinoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1482HRASpituitary,NS,adenoma,PRL3
2483HRASpituitary,NS,adenoma,PRL3
3760PIK3CApituitary,NS,adenoma,PRL3
4771PIK3CApituitary,NS,adenoma,PRL3

Expression for genes affiliated with Prolactinoma

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Search GEO for disease gene expression data for Prolactinoma.

Pathways for genes affiliated with Prolactinoma

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Compounds for genes affiliated with Prolactinoma

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Compounds related to Prolactinoma according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1ghrp4310.1GHRHR, PRL
2lanreotide43 2811.1SSTR5, PRL
3hexarelin43 2811.1GHRHR, PRL
4clomiphene citrate439.8CGB, PRL
5bromocriptine43 28 1211.8POU1F1, PRL
6octreotide43 59 28 1212.7PRL, SSTR5
7silver439.7TRHR, GHRHR
8ribonucleic acid439.3POU1F1, PRL, SSTR5, GHRHR
9androstenedione43 2410.2CGB, PRL
10forskolin43 49 1211.1CNTF, GHRHR, POU1F1
11arginine439.0POU1F1, PRL, GHRHR, CNTF
12norepinephrine43 24 1211.0CNTF, PRL, CHGB
13thymidine43 2410.0POU1F1, SSTR5, MEN1, CNTF
14acth438.9POU1F1, CHGB, PRL, SSTR5
15progesterone43 28 59 24 1212.8POU1F1, PRL, CNTF, CGB
16cyclic amp43 249.8POU1F1, GHRHR, CNTF, CGB
17glucose438.7PRL, GHRHR, CNTF, CGB
18dexamethasone43 49 28 1211.7POU1F1, CHGB, PRL, GHRHR
19alanine438.6POU1F1, CNTF, TRHR, CGB
20dopamine43 28 24 1211.4CNTF, SSTR5, PRL, CHGB, POU1F1
21estrogen438.1CGB, MEN1, PRL, CHGB, POU1F1
22tyrosine438.0CNTF, MEN1, SSTR5, CHGB, POU1F1
23calcium43 49 24 1210.4POU1F1, CHGB, SSTR5, MEN1, GHRHR, CNTF

GO Terms for genes affiliated with Prolactinoma

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Cellular components related to Prolactinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear matrixGO:00163639.6GHRHR, MEN1
2secretory granuleGO:00301419.0GHRHR, CHGB

Biological processes related to Prolactinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1somatotropin secreting cell developmentGO:00601339.8GHRHR, POU1F1
2determination of adult lifespanGO:00083409.7GHRHR, POU1F1
3lactationGO:00075959.7PRL, GHRHR
4positive regulation of multicellular organism growthGO:00400189.6GHRHR, POU1F1
5positive regulation of cell proliferationGO:00082849.1CNTF, GHRHR, POU1F1
6negative regulation of cell proliferationGO:00082858.9MEN1, SSTR5, POU1F1

Molecular functions related to Prolactinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.7CGB, PRL, CHGB

Products for genes affiliated with Prolactinoma

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Sources for Prolactinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet