FIPA
MCID: PRL009
MIFTS: 71

Prolactinoma (FIPA) malady

Endocrine diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases categories

Summaries for Prolactinoma

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 A prolactinoma is a benign tumor (adenoma) of the pituitary gland that produces a hormone called... more...

MalaCards: Prolactinoma, also known as pituitary adenoma, prolactin-secreting, is related to adenoma and pituitary adenoma. An important gene associated with Prolactinoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are GPCRs, Other and G alpha (q) signalling events. The compounds [125i]cgp 23996 and cgp 23996 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and thyroid, and related mouse phenotypes are digestive/alimentary and endocrine/exocrine gland.

Description from OMIM:46 600634,102200

Aliases & Classifications for Prolactinoma

About this section
Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
familial isolated pituitary adenoma:
Inheritance: Autosomal dominant; Age of onset: Variable


Aliases & Descriptions:

prolactinoma 8 44 48 60
pituitary adenoma, prolactin-secreting 8 9 46
prolactinoma, familial 42 22
prolactin-secreting pituitary adenoma 48
pituitary adenoma, familial isolated 60
familial isolated pituitary adenoma 48
multiple gastrointestinal atresias 60
prolactinoma of pituitary gland 8
prl-secreting pituitary adenoma 48
pituitary lactotrophic adenoma 48
familial prolactinoma 8
lactotroph adenoma 48
prloma 48
fipa 48


External Ids:

Disease Ontology8 DOID:5394
MeSH34 D015175
NCIt39 C3342
MESH via Orphanet35 D015175
ICD10 via Orphanet26 D35.2, E22.1
SNOMED-CT via Orphanet57 134209002, 34337008
UMLS via Orphanet61 C0033375

Related Diseases for Prolactinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Prolactinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.7DRD2, GNRHR, TRHR, AIP, SSTR3, SSTR4
2pituitary adenoma30.7PTTG1, FGF4, POU1F1, TRH, TRHR, AIP
3hyperprolactinemia30.6DRD2, PRL, TRH
4acromegaly30.5AIP, SSTR1, SSTR2, SSTR5, PRL, GHSR
5pituitary apoplexy30.4PRL, TRH
6thyroiditis30.3TRH
7hyperparathyroidism30.1MEN1
8hypogonadism30.1POU1F1, TRH, PRL, GNRHR
9meningioma30.1MEN1, SSTR5, SSTR2
10breast cancer30.0GNRHR, CHGB, SSTR2, NGFR, FGF4, PTTG1
11exophthalmos30.0TRH
12craniopharyngioma29.7PRL, TRH
13gastrinoma29.7SSTR1, SSTR2, SSTR5, MEN1
14obesity29.7DRD2, GHSR, TRH
15empty sella syndrome29.7POU1F1, PRL
16adenocarcinoma29.7GNRHR, MEN1, CHGB, SSTR2, SSTR1, POU1F1
17aip-related familial isolated pituitary adenomas10.5
18mixed cell adenoma10.3
19pseudotumor cerebri10.3
20psychotic disorder10.3
21multiple intestinal atresia10.2
22familial meningioma10.2
23gangliocytoma10.1
24hydrocephalus10.1
25imperforate anus10.1
26familial isolated pituitary adenoma10.1
27systemic lupus erythematosus10.1
28adrenal adenoma10.1
29functioning pituitary adenoma10.1
30lupus erythematosus10.1
31schizophrenia10.1
32transsexualism10.0
33autoimmune thyroiditis10.0
34neuronitis10.0
35schizoaffective disorder10.0
36gynecomastia10.0
37obstructive hydrocephalus10.0
38pathological gambling10.0
39osteoporosis10.0
40cervicitis10.0
41leukemia10.0
42meningitis10.0
43pancreatitis10.0
44personality disorder10.0
45turner syndrome10.0
46gigantism10.0AIP, PRL
47anovulation10.0PRL
48endogenous depression10.0TRH
49acth deficiency10.0POU1F1, PRL
50addison's disease10.0GNRHR

Graphical network of the top 20 diseases related to Prolactinoma:



Diseases related to prolactinoma

Clinical Features for Prolactinoma

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

600634,102200

Clinical synopsis from OMIM:

600634

Drugs & Therapeutics for Prolactinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Prolactinoma

Drug clinical trials:

Search ClinicalTrials for Prolactinoma

Search NIH Clinical Center for Prolactinoma

Search CenterWatch for Prolactinoma

Genetic Tests for Prolactinoma

About this section
Sources:
22GTR
See all sources

Genetic tests related to Prolactinoma:

id Genetic test Affiliating Genes
1 Prolactinoma, Familial22

Anatomical Context for Prolactinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Prolactinoma:

32
Pituitary, Bone, Thyroid, Breast, Heart, Brain, Ovary, Testes, Colon, Hypothalamus, T cells, Prostate, Skin, Kidney, Spinal cord

Animal Models for Prolactinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Prolactinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.3NGFR, SSTR2, GHSR, MEN1, DRD2, GNRHR
2MP:000537910.3CORT, GNRHR, DRD2, MEN1, GHRHR, PRL
3MP:000537810.2GHRHR, MEN1, DRD2, GNRHR, CORT, GHSR
4MP:000538610.2CORT, DRD2, GHRHR, GHSR, PRL, SSTR2
5MP:000363110.2PRL, GHRHR, MEN1, DRD2, CHGB, SSTR2
6MP:000538910.2GNRHR, DRD2, MEN1, GHRHR, PRL, TRHR
7MP:000537610.2PTTG1, CORT, GNRHR, DRD2, MEN1, GHRHR
8MP:001077110.1GNRHR, DRD2, GHRHR, AIP

Publications for Prolactinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Prolactinoma:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Preclinical Atherosclerosis in Patients with Prolactinoma. (24325995)
2013
2
Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy. (23683075)
2013
3
Higher doses of cabergoline further improve metabolic parameters in patients with prolactinoma regardless of the degree of reduction in prolactin levels. (23506485)
2013
4
A risperidone-induced prolactinoma resolved when a woman with schizoaffective disorder switched to ziprasidone: a case report. (23074699)
2012
5
A Case Report and Review of Hyperprolactinemia that is not Prolactinoma. (21672707)
2011
6
Double pituitary prolactinoma. (21051581)
2010
7
Aggressive prolactinoma in a child related to germline mutation in the ARYL hydrocarbon receptor interacting protein (AIP) gene. (21340166)
2010
8
Valvular heart disease and the use of cabergoline for the treatment of prolactinoma. (19128367)
2009
9
Long-term cabergoline therapy is not associated with valvular heart disease in patients with prolactinomas. (18594989)
2009
10
Prolactinoma in children and adolescents. (19786791)
2009
11
A novel use of temozolomide in a patient with malignant prolactinoma. (19818629)
2009
12
Somatostatinergic ligands in dopamine-sensitive and -resistant prolactinomas. (18426817)
2008
13
Insulin-like growth factor-I gene therapy reverses morphologic changes and reduces hyperprolactinemia in experimental rat prolactinomas. (18218140)
2008
14
Giant prolactinoma mimicking bone tumor. (24299644)
2007
15
Inhibitory effect of thalidomide on the growth, secretory function and angiogenesis of estrogen-induced prolactinoma in Fischer 344 rats. (16846617)
2006
16
Prevalence of osteopenia in men with prolactinoma. (15816365)
2005
17
Body weight and prolactinoma: a retrospective study. (14610525)
2004
18
Suprasellar peri-infundibular ectopic prolactinoma--case report. (12568324)
2003
19
Male prolactinoma with pituitary apoplexy concomitant with intracerebral hemorrhage--case report. (11936054)
2002
20
Giant prolactinomas presenting as skull base tumors. (11904200)
2002
21
Latent prolactinoma on MRI-selective venous sampling and trans-sphenoidal microsurgical treatment. (11680507)
2001
22
Pregnancy in a patient with prolactinoma off treatment. (11280238)
2000
23
Ectopic prolactinoma in the clivus. (9538914)
1998
24
Treatment of prolactinomas. (9814831)
1998
25
Prolactinoma presenting in identical twins with multiple endocrine neoplasia type 1. (8846498)
1996
26
Pituitary prolactinoma mimicking tumor originating from the sphenoid sinus or clivus. (8916261)
1996
27
Calcified cystic pituitary prolactinoma. (7561579)
1995
28
Nerve growth factor and bromocriptine: a sequential therapy for human bromocriptine-resistant prolactinomas. (8519650)
1995
29
Bromocriptine for prolactinoma-related dissociative disorder and depression. (7782492)
1995
30
Ectopic prolactinoma on MRI. (7962804)
1994
31
Decreased expression of the two D2 dopamine receptor isoforms in bromocriptine-resistant prolactinomas. (7969790)
1994
32
Prolactinoma associated with transient growth hormone deficiency but persistent growth retardation. (8186829)
1994
33
Giant basal prolactinoma extending into the nasal cavity. (1595040)
1992
34
Prolactinomas and resistance to dopamine agonists. (1306523)
1992
35
Prolactin isoforms secreted by human prolactinomas. (1306849)
1992
36
Influence of pregnancy on the serum prolactin level following prolactinoma surgery. (1950339)
1991
37
Lymphocyte abnormalities in patients with macro- and micro-prolactinoma: different effects of bromocriptine treatment in the two groups. (2279881)
1990
38
Long-term follow-up of 'cured' prolactinoma patients after successful adenomectomy. (2114241)
1990
39
Prolactin-lowering effect of luteinizing hormone-releasing hormone agonist administration in prolactinoma patients. (2526819)
1989
40
Pre- and post-operative hypothalamic-pituitary-thyroidal axis function in patients with prolactinoma, growth hormone tumour and ACTH tumour. (2551602)
1989
41
Mass screening for hyperprolactinemia and prolactinoma in men. (3183301)
1988
42
Hyperprolactinaemia; when is a prolactinoma not a prolactinoma? (2889909)
1987
43
Sipple's syndrome associated with a large prolactinoma. (2897262)
1987
44
Pituitary tumor (prolactinoma) (3951225)
1986
45
Ectopic prolactinoma in a patient with hyperparathyroidism and abnormal sellar radiography. (3958123)
1986
46
Role of defective dopaminergic inhibition of prolactin secretion in the pathogenesis of prolactinoma. (3974842)
1985
47
Breast cancer in a patient with prolactinoma. (2992109)
1985
48
Galactorrhoea following hypophysectomy in a boy with a prolactinoma. (6540876)
1984
49
An unusual course of prolactinoma during two consecutive pregnancies. (6500151)
1984
50
Prolactinoma of pituitary with associated amyloid-like substances. Case report. (6631502)
1983

Genetic Variations for Prolactinoma

About this section

Expression for genes affiliated with Prolactinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Prolactinoma

Search GEO for disease gene expression data for Prolactinoma.

Pathways for genes affiliated with Prolactinoma

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 29KEGG
See all sources

Compounds for genes affiliated with Prolactinoma

About this section
Sources:
28IUPHAR, 44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Prolactinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1[125i]cgp 239962810.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
2cgp 239962810.8SSTR4, SSTR1, SSTR2, SSTR5, SSTR3
3ke 1082810.8SSTR2, SSTR3, SSTR4, SSTR1, SSTR5
4[125i]tyr10-cst142810.8SSTR5, SSTR2, SSTR3, SSTR4, SSTR1
5srif-142810.8SSTR5, SSTR3, SSTR4, SSTR1, SSTR2
6cst-172810.8SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
7bim 230522810.8SSTR2, SSTR4, SSTR5, SSTR1, SSTR3
8srif-282810.8SSTR3, SSTR1, SSTR2, SSTR5, SSTR4
9estrogen4410.8TRH, PTTG1
10[125i]ltt-srif-282810.8SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
11[d-tyr8]cyn 1548062810.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
12bim 234542810.7SSTR1, SSTR4, SSTR3, SSTR2, SSTR5
13bim 236272810.7SSTR2, SSTR1, SSTR4, SSTR5, SSTR3
14l-362,8552810.7SSTR5, SSTR1, SSTR4, SSTR2, SSTR3
15lanreotide44 2811.7PRL, GHSR, SSTR5, SSTR2, SSTR1, SSTR3
16som-2302810.7SSTR5, SSTR2, SSTR3, SSTR1
17[l-tyr8]cyn 1548062810.7SSTR3, SSTR2, SSTR1, SSTR4, SSTR5
18cst-142810.7SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
19cyclosomatostatin5910.7SSTR5, SSTR3, SSTR4, SSTR2, SSTR1
20pasireotide44 1111.7SSTR3, SSTR1, SSTR2, SSTR5
21(1r,1s,3r/1r,1r,3s)-l-054,2645910.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
22vapreotide28 44 1112.7GHSR, SSTR3, SSTR2, SSTR5, CORT
23cyn 1548065910.7SSTR2, SSTR1, SSTR4, SSTR3, SSTR5
24des-aa5-[d-trp8]srif2810.7SSTR5, SSTR4, SSTR3, SSTR1
25somatostatin59 2411.7SSTR5, SSTR4, SSTR1, SSTR2, SSTR3
26ghrp4410.7TRH, GHRHR, GHSR, PRL
27bromocriptine28 44 1112.7POU1F1, GNRHR, PRL, TRH
28[111in,90y]dota-toc2810.7SSTR5, SSTR2, SSTR3
29hexarelin44 2811.7CORT, GHSR, GHRHR, PRL
30[111in,90y]dota-lan2810.7SSTR2, SSTR5, SSTR3
31ribonucleic acid4410.7GNRHR, SSTR5, GHSR, PRL, SSTR2, SSTR1
32noc-ate2810.7SSTR3, SSTR5, SSTR2
33dopamine44 28 11 2413.6GNRHR, DRD2, PTTG1, NGFR, TRH, SSTR1
34acth4410.6GHSR, TRH, SSTR2, CHGB, CORT, POU1F1
35octreotide44 59 28 1113.6CORT, DRD2, GHSR, PRL, SSTR2, SSTR1
36prl-29152810.6SSTR3, SSTR4, SSTR5
37nc 4-28b2810.6SSTR2, SSTR1, SSTR3
38[111in,90y]dota-oc2810.6SSTR5, SSTR2, SSTR3
39thymidine44 2411.6PTTG1, TRH, SSTR5, MEN1, GNRHR, NGFR
40mk-6782810.6SSTR2, SSTR3, SSTR5
41[111in]dota-noc-ate2810.5SSTR5, SSTR2, SSTR3
42adenylate4410.5GNRHR, CORT, SSTR2, DRD2, GHRHR, GHSR
43[111in]dota-noc2810.5SSTR5, SSTR2, SSTR3
44tyrosine4410.5CORT, FGF4, NGFR, POU1F1, TRH, GNRHR
45calcium44 49 11 2413.5PTTG1, POU1F1, TRH, SSTR5, CHGB, NGFR
46bim 230682810.4SSTR2, SSTR4, SSTR3
47bim 230302810.4SSTR3, SSTR2, SSTR5
48bim 230502810.4SSTR5, SSTR1, SSTR3
49bim 231972810.3SSTR5, SSTR2, SSTR3
50[111in,90y]dota-noc2810.1SSTR5, SSTR2, SSTR3

GO Terms for genes affiliated with Prolactinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.4TRH, CHGB, PRL, GHRHR
2integral to plasma membraneGO:00588710.1NGFR, GNRHR, DRD2, SSTR5, SSTR2, SSTR1
3plasma membraneGO:0058869.8SSTR5, GHSR, GHRHR, DRD2, GNRHR, SSTR2

Biological processes related to Prolactinoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of multicellular organism growthGO:04001810.7DRD2, GHRHR, GHSR, POU1F1
2cellular response to glucocorticoid stimulusGO:07138510.7SSTR3, SSTR4, SSTR2
3cellular response to estradiol stimulusGO:07139210.7SSTR2, SSTR1, SSTR3
4somatostatin signaling pathwayGO:03817010.7SSTR3, SSTR5
5somatotropin secreting cell developmentGO:06013310.7POU1F1, GHRHR
6forebrain developmentGO:03090010.7SSTR2, SSTR1, SSTR4, SSTR3
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.7SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
8cerebellum developmentGO:02154910.7SSTR2, SSTR1, SSTR3
9response to starvationGO:04259410.6SSTR2, SSTR1, SSTR3
10negative regulation of cell proliferationGO:00828510.6POU1F1, DRD2, MEN1, SSTR5, SSTR2, SSTR1
11cell-cell signalingGO:00726710.6FGF4, TRH, SSTR3, SSTR1, SSTR2
12response to nutrientGO:00758410.6SSTR1, SSTR2, PRL
13positive regulation of growth hormone secretionGO:06012410.6DRD2, GHRHR
14peristalsisGO:03043210.5DRD2, SSTR2
15G-protein coupled receptor signaling pathwayGO:00718610.5GNRHR, GHSR, SSTR5, SSTR4, TRHR
16growth hormone secretionGO:03025210.5GHRHR, GHSR
17positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.4GHRHR, GHSR
18hormone-mediated signaling pathwayGO:00975510.4TRH, GHSR
19determination of adult lifespanGO:00834010.3GHRHR, POU1F1
20spermatogenesisGO:00728310.1PTTG1, SSTR3, SSTR1, SSTR2

Molecular functions related to Prolactinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth hormone-releasing hormone receptor activityGO:01652010.4GHSR, GHRHR
2somatostatin receptor activityGO:00499410.0SSTR3, SSTR4, SSTR1, SSTR2, SSTR5

Products for genes affiliated with Prolactinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prolactinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet