PDR
MCID: PRL007
MIFTS: 54

Proliferative Diabetic Retinopathy (PDR) malady

Eye diseases category
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Summaries for Proliferative Diabetic Retinopathy

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MalaCards based summary: Proliferative Diabetic Retinopathy, also known as pigmentary disorder, reticulate, with systemic manifestations, is related to retinal detachment and diabetic macular edema. An important gene associated with Proliferative Diabetic Retinopathy is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are Integrins in angiogenesis and Signaling events mediated by TCPTP. The compounds fluorescein and triamcinolone acetonide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and monocytes, and related mouse phenotypes are digestive/alimentary and vision/eye.

Aliases & Classifications for Proliferative Diabetic Retinopathy

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Proliferative Diabetic Retinopathy, Aliases & Descriptions:

Name: Proliferative Diabetic Retinopathy 8 10 44 62
Pigmentary Disorder, Reticulate, with Systemic Manifestations 62
 
Pdr 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:13207
ICD9CM27 362.02
SNOMED-CT57 59276001, 154679002
NCIt39 C84457

Related Diseases for Proliferative Diabetic Retinopathy

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Diseases related to Proliferative Diabetic Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1retinal detachment31.8SERPINF1, VEGFA
2diabetic macular edema31.4SERPINF1, VEGFA
3diabetic retinopathy31.3VEGFA, CTGF, VTN, ANGPT2, VCAM1, SERPINF1
4macular holes31.2PTGDS, SERPINF1, ANGPT2
5proliferative vitreoretinopathy31.1CCL2, VTN, HGF, CTGF
6blindness30.5VEGFA, TIMP3, SERPINF1
7diabetic nephropathy30.4CTGF, CCL2, SERPINF1, TIMP3
8uveitis30.4CCL2, CXCL10, SERPINF1
9type 2 diabetes mellitus30.3VCAM1, CXCL10, CCL2
10proteinuria30.3VEGFA, ANGPT2, CCL2, VTN, CTGF
11diabetes mellitus30.2VEGFA, VCAM1, ANGPT2, CCL2, VTN, CTGF
12ischemia30.1VEGFA, ANGPT2, VTN, HGF, CTGF
13encephalitis30.0VCAM1, CXCL10, CCL2
14osteoarthritis29.2TIMP3, VCAM1, CXCL10, ANGPT2, CCL2, CTGF
15retinitis11.1
16endotheliitis11.1
17neovascular glaucoma10.6
18retinopathy of prematurity10.5VEGFA
19retinal vein occlusion10.5VEGFA
20central retinal vein occlusion10.5VEGFA
21cataract10.4
22background diabetic retinopathy10.4
23eales disease10.4
24hypoxia10.4
25macular retinal edema10.4VEGFA, SERPINF1
26type 1 diabetes mellitus10.4
27acromegaly10.4
28rubeosis iridis10.4
29artery disease10.4
30retinal disease10.4
31retinoschisis10.4
32sleep disorder10.4
33x-linked reticulate pigmentary disorder with systemic manifestations10.3
34leukostasis10.3VCAM1
35age related macular degeneration10.3TIMP3, VEGFA
36vascular disease10.2VEGFA, PTGDS, ANGPT2
37retinal vascular disease10.2VEGFA, SERPINF1, CTGF
38paragonimiasis10.2
39ureteral disease10.2CTGF, CCL2
40leukemia10.2
41retinal ischemia10.2
42retinitis pigmentosa10.2
43hemochromatosis10.2
44central retinal artery occlusion10.2
45carotid stenosis10.2
46gestational diabetes10.2
47vitreous detachment10.2
48maturity-onset diabetes of the young10.2
49severe nonproliferative diabetic retinopathy10.2
50choroiditis10.2

Graphical network of the top 20 diseases related to Proliferative Diabetic Retinopathy:



Diseases related to proliferative diabetic retinopathy

Symptoms for Proliferative Diabetic Retinopathy

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Drugs & Therapeutics for Proliferative Diabetic Retinopathy

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Drug clinical trials:

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Search NIH Clinical Center for Proliferative Diabetic Retinopathy

Genetic Tests for Proliferative Diabetic Retinopathy

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Anatomical Context for Proliferative Diabetic Retinopathy

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MalaCards organs/tissues related to Proliferative Diabetic Retinopathy:

32
Endothelial, Eye, Monocytes, Placenta, Retina, T cells, Tongue

Animal Models for Proliferative Diabetic Retinopathy or affiliated genes

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MGI Mouse Phenotypes related to Proliferative Diabetic Retinopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5VEGFA, SERPINF1, ANGPT2, CCL2, CTGF
2MP:00053918.1VEGFA, TIMP3, SERPINF1, ANGPT2, CCL2, CTGF
3MP:00107718.0VEGFA, PTGDS, TIMP3, ANGPT2, CCL2, CTGF
4MP:00053847.3VEGFA, TIMP3, CXCL10, CCL2, HGF, CTGF
5MP:00053787.3CTGF, HGF, CCL2, VCAM1, TIMP3, VEGFA
6MP:00053877.0VEGFA, PTGDS, TIMP3, VCAM1, CXCL10, ANGPT2
7MP:00053976.7VEGFA, PTGDS, TIMP3, VCAM1, CXCL10, CCL2
8MP:00053856.4CTGF, VEGFA, TIMP3, SERPINF1, VCAM1, CXCL10
9MP:00053766.4VEGFA, PTGDS, TIMP3, VCAM1, CXCL10, ANGPT2
10MP:00107686.3VEGFA, PTGDS, TIMP3, VCAM1, CXCL10, ANGPT2

Publications for Proliferative Diabetic Retinopathy

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Articles related to Proliferative Diabetic Retinopathy:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Fourier-domain optical coherence tomography evaluation of retinal and optic nerve head neovascularisation in proliferative diabetic retinopathy. (24158844)
2014
2
Effects of laser photocoagulation on serum angiopoietin-1, angiopoietin-2, angiopoietin-1/angiopoietin-2 ratio, and soluble angiopoietin receptor Tie-2 levels in type 2 diabetic patients with proliferative diabetic retinopathy. (25161936)
2014
3
Effect of intravitreal bevacizumab on serum, aqueous, and vitreous humor levels of erythropoietin in patients with proliferative diabetic retinopathy. (25371057)
2014
4
Aldo-keto reductase and sorbitol dehydrogenase enzymes in Egyptian diabetic patients with and without proliferative diabetic retinopathy. (23452182)
2013
5
Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry. (23276812)
2013
6
Computer-aided diagnosis of proliferative diabetic retinopathy via modeling of the major temporal arcade in retinal fundus images. (23579735)
2013
7
High vitreous concentration of IL-6 and IL-8, but not of adhesion molecules in relation to plasma concentrations in proliferative diabetic retinopathy. (23257933)
2013
8
Cysteine-rich 61 (CYR61) is up-regulated in proliferative diabetic retinopathy. (22160564)
2012
9
Plasma, aqueous and vitreous homocysteine levels in proliferative diabetic retinopathy. (22353698)
2012
10
Topographical distribution of retinal and optic disc neovascularization in early stages of proliferative diabetic retinopathy. (23169887)
2012
11
Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy. (22618595)
2012
12
Imbalanced levels of angiogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy. (22699109)
2012
13
Relationship between vitreous and serum vascular endothelial growth factor levels, control of diabetes and microalbuminuria in proliferative diabetic retinopathy. (22331976)
2012
14
Effects of bevacizumab on the neovascular membrane of proliferative diabetic retinopathy: reduction of endothelial cells and expressions of VEGF and HIF-1I+. (22232563)
2012
15
Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy. (21691136)
2012
16
Electroretinographic findings associated with panretinal photocoagulation (PRP) versus PRP plus intravitreal ranibizumab treatment for high-risk proliferative diabetic retinopathy. (22457045)
2012
17
Surgical and visual outcome following 20-gauge vitrectomy in proliferative diabetic retinopathy over a 10-year period, evidence for change in practice. (22241020)
2012
18
Characterisation of the vitreous proteome in proliferative diabetic retinopathy. (22390717)
2012
19
Intraocular expression of serum amyloid a and interleukin-6 in proliferative diabetic retinopathy. (21704966)
2011
20
Macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy. (22125532)
2011
21
Changes in adrenomedullin in patients with proliferative diabetic retinopathy. (21942228)
2011
22
Ophthalmodynamometric pressure in eyes with proliferative diabetic retinopathy measured during pars plana vitrectomy. (21236404)
2011
23
Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathy. (19381432)
2010
24
Anti-VEGF therapy in proliferative diabetic retinopathy. (19349790)
2009
25
Morphologic changes in the anterior segment after phacovitrectomy for proliferative diabetic retinopathy. (19393886)
2009
26
Panretinal photocoagulation combined with intravitreal bevacizumab in high-risk proliferative diabetic retinopathy. (19262436)
2009
27
Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy. (19639332)
2009
28
The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy. (18628999)
2008
29
Profiling of vitreous proteomes from proliferative diabetic retinopathy and nondiabetic patients. (17955474)
2007
30
Optos Panoramic200A fluorescein angiography for proliferative diabetic retinopathy with asteroid hyalosis. (17564923)
2007
31
Oral sodium fluorescein to improve visualization of clear vitreous during vitrectomy for proliferative diabetic retinopathy. (18173410)
2007
32
Immunoreactive endothelin-1 in the vitreous humor and epiretinal membranes of patients with proliferative diabetic retinopathy. (17290206)
2007
33
Proteomic analysis of human vitreous fluid by fluorescence-based difference gel electrophoresis (DIGE): a new strategy for identifying potential candidates in the pathogenesis of proliferative diabetic retinopathy. (17380318)
2007
34
Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy]. (18051819)
2007
35
Elevated serum levels of N(epsilon)-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macular oedema. (15258735)
2004
36
CD4-CD8 and CD28 expression in T cells infiltrating the vitreous fluid in patients with proliferative diabetic retinopathy: a flow cytometric analysis. (15136323)
2004
37
Proliferative diabetic retinopathy. (15577565)
2004
38
The prognostic value of post-treatment retinopathy after panretinal photocoagulation for proliferative diabetic retinopathy in type 1 diabetes. (15638104)
2004
39
Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. a pilot study. (12920663)
2003
40
Has the frequency of proliferative diabetic retinopathy declined in the US? (12941740)
2003
41
Increased permeability of the blood-aqueous barrier after panretinal photocoagulation for proliferative diabetic retinopathy. (11453865)
2001
42
Tissue factor increases in the aqueous humor of proliferative diabetic retinopathy. (11789868)
2001
43
Effect of retinal coagulation status on oxidative metabolite and VEGF in 208 patients with proliferative diabetic retinopathy]. (11258131)
2001
44
Detection of glutamate and gamma-aminobutyric acid in vitreous of patients with proliferative diabetic retinopathy. (12579648)
2000
45
Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. (10741691)
2000
46
Increased vitreous concentrations of human hepatocyte growth factor in proliferative diabetic retinopathy. (10022434)
1999
47
Iridopathy in eyes with proliferative diabetic retinopathy: detection of early stage of rubeosis iridis. (9438578)
1998
48
Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. (9298058)
1997
49
Asymmetric proliferative diabetic retinopathy and carotid artery disease. (2381700)
1990
50
Filtering valve implant for neovascular glaucoma in proliferative diabetic retinopathy. (6178066)
1982

Variations for Proliferative Diabetic Retinopathy

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Expression for genes affiliated with Proliferative Diabetic Retinopathy

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Expression patterns in normal tissues for genes affiliated with Proliferative Diabetic Retinopathy

Search GEO for disease gene expression data for Proliferative Diabetic Retinopathy.

Pathways for genes affiliated with Proliferative Diabetic Retinopathy

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Pathways related to Proliferative Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8VTN, VEGFA
29.8VEGFA, HGF
39.7CCL2, VEGFA
49.6CTGF, VTN
5
Show member pathways
Angiogenesis37
9.6VEGFA, TIMP3
6
Show member pathways
9.4HGF, ANGPT2, VEGFA
7
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.4HGF, VTN, VEGFA
8
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.4VEGFA, VTN, HGF
99.1VCAM1, CCL2
109.1VEGFA, ANGPT2, VTN, HGF
11
Show member pathways
9.0CTGF, HGF, TIMP3
12
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
8.8CCL2, VCAM1, VEGFA
138.8VEGFA, TIMP3, VTN, HGF
148.7HGF, CCL2, VCAM1
158.6VCAM1, CXCL10, CCL2
16
Show member pathways
8.3TIMP3, SERPINF1, VTN, HGF, CTGF
17
Show member pathways
8.2VTN, CCL2, CXCL10, VCAM1
18
Show member pathways
8.1TIMP3, ANGPT2, CCL2, HGF, CTGF
19
Show member pathways
8.1VEGFA, SERPINF1, CXCL10, ANGPT2, CCL2, HGF
20
Show member pathways
7.6TIMP3, VCAM1, CCL2, HGF, CTGF
21
Show member pathways
7.6TIMP3, CXCL10, ANGPT2, CCL2, HGF, CTGF
22
Show member pathways
7.6TIMP3, CXCL10, ANGPT2, CCL2, HGF, CTGF
23
Show member pathways
7.6CTGF, TIMP3, CXCL10, ANGPT2, CCL2, HGF

Compounds for genes affiliated with Proliferative Diabetic Retinopathy

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Compounds related to Proliferative Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1fluorescein44 1110.5VEGFA, SERPINF1, HGF
2triamcinolone acetonide44 2810.4VCAM1, SERPINF1, VEGFA
3streptozotocin449.3CTGF, HGF, SERPINF1
4ang ii449.2CTGF, CCL2, VEGFA
5cilostazol44 1110.0VCAM1, CCL2, HGF
6glycosaminoglycan449.0VTN, CXCL10, SERPINF1, TIMP3
7diphenyleneiodonium448.9VEGFA, SERPINF1, VCAM1, CCL2
8hyaluronic acid44 249.8VEGFA, VCAM1, VTN, HGF
9pioglitazone28 44 50 1111.7CTGF, CCL2, VCAM1, VEGFA
10groalpha448.7CCL2, CXCL10, VCAM1
11heparan sulfate44 249.7TIMP3, CXCL10, VTN, HGF
12simvastatin44 50 61 28 24 1113.6VEGFA, VCAM1, CCL2, CTGF
13losartan44 50 28 1111.6CTGF, HGF, CCL2, VCAM1
14cyclophosphamide44 50 1110.6VEGFA, VCAM1, CCL2, HGF
15sp 60012544 619.6VCAM1, CCL2, HGF, CTGF
16herbimycin a44 619.6VCAM1, CCL2, VTN, HGF
17cytochalasin d44 619.6VCAM1, CCL2, VTN, CTGF
1815-deoxy-delta-12,14-prostaglandin j2448.5VEGFA, PTGDS, VCAM1, CCL2, CTGF
19curcumin448.4VEGFA, VCAM1, CCL2, VTN, CTGF
20fibrinogen448.3VCAM1, ANGPT2, CCL2, VTN, CTGF
21sb 20358044 619.3VEGFA, VCAM1, CCL2, HGF, CTGF
22creatinine448.3PTGDS, CXCL10, ANGPT2, CCL2, HGF, CTGF
23histamine44 28 2410.2HGF, CCL2, CXCL10, VCAM1, PTGDS
24n acetylcysteine448.1VEGFA, SERPINF1, VCAM1, CCL2, HGF, CTGF
25tgf beta1448.0TIMP3, VCAM1, CCL2, HGF, CTGF
26prostacyclin448.0VEGFA, VCAM1, CCL2, VTN, HGF, CTGF
27cycloheximide448.0VEGFA, PTGDS, CXCL10, CCL2, VTN, HGF
28paraffin447.9VEGFA, TIMP3, VCAM1, ANGPT2, CCL2, HGF
29nitric oxide44 24 119.9SERPINF1, VCAM1, CXCL10, ANGPT2, CCL2, CTGF
30cysteine447.8TIMP3, SERPINF1, VCAM1, ANGPT2, VTN, CTGF
31pd 98,059447.7TIMP3, VCAM1, CCL2, VTN, HGF, CTGF
32genistein44 28 61 2 24 1112.7VEGFA, TIMP3, VCAM1, CXCL10, CCL2, HGF
33testosterone44 61 24 1110.7PTGDS, TIMP3, VCAM1, CCL2, HGF
34heparin44 28 24 1110.6VEGFA, TIMP3, SERPINF1, VCAM1, VTN, HGF
35cholesterol44 28 24 1110.6PTGDS, VCAM1, CXCL10, CCL2, VTN
36serine447.6SERPINF1, VCAM1, ANGPT2, CCL2, VTN, HGF
37oxygen44 248.4TIMP3, SERPINF1, VCAM1, ANGPT2, CCL2, HGF
38wortmannin447.3TIMP3, VCAM1, CXCL10, ANGPT2, CCL2, VTN
39glucose447.3TIMP3, SERPINF1, VCAM1, CXCL10, ANGPT2, CCL2
40matrigel447.3VEGFA, TIMP3, SERPINF1, VCAM1, CXCL10, ANGPT2
41pge2447.2VEGFA, VCAM1, CXCL10, ANGPT2, CCL2, VTN
42estrogen447.1VEGFA, PTGDS, TIMP3, VCAM1, CXCL10, ANGPT2
43ly294002447.1VEGFA, TIMP3, VCAM1, ANGPT2, CCL2, VTN
44calcium44 50 24 1110.0PTGDS, TIMP3, SERPINF1, CXCL10, ANGPT2, CCL2
45phosphatidylinositol446.9TIMP3, VCAM1, CXCL10, ANGPT2, CCL2, VTN
46lipid446.8PTGDS, TIMP3, VCAM1, CXCL10, CCL2, VTN
47tyrosine446.8VEGFA, TIMP3, SERPINF1, VCAM1, CXCL10, ANGPT2
48retinoic acid44 247.8PTGDS, TIMP3, SERPINF1, VCAM1, CXCL10, ANGPT2
49vegf446.3CTGF, VEGFA, HGF, VTN, CCL2, ANGPT2
50dexamethasone44 50 28 119.3VTN, CCL2, ANGPT2, CXCL10, VCAM1, SERPINF1

GO Terms for genes affiliated with Proliferative Diabetic Retinopathy

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Cellular components related to Proliferative Diabetic Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.8HGF, VEGFA
2extracellular matrixGO:0310129.1TIMP3, SERPINF1, VTN
3proteinaceous extracellular matrixGO:0055789.0CTGF, VTN, VEGFA
4extracellular regionGO:0055766.9VEGFA, PTGDS, SERPINF1, CXCL10, ANGPT2, CCL2
5extracellular spaceGO:0056156.2CTGF, VEGFA, PTGDS, SERPINF1, VCAM1, CXCL10

Biological processes related to Proliferative Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.0VEGFA, VTN
2positive chemotaxisGO:0509189.8HGF, VEGFA
3vascular endothelial growth factor receptor signaling pathwayGO:0480109.8CCL2, VEGFA
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7VEGFA, VTN, HGF
5response to amino acidGO:0432009.6CCL2, CTGF
6response to glucocorticoidGO:0513849.6CCL2, SERPINF1, PTGDS
7cellular response to vascular endothelial growth factor stimulusGO:0359249.5VCAM1, VEGFA
8organ regenerationGO:0311009.5HGF, CCL2, ANGPT2
9negative regulation of endopeptidase activityGO:0109519.4TIMP3, SERPINF1, VTN
10chemokine-mediated signaling pathwayGO:0700989.4CXCL10, CCL2
11response to gamma radiationGO:0103329.3CXCL10, CCL2
12response to activityGO:0148239.3CCL2, ANGPT2
13cell chemotaxisGO:0603269.2HGF, VCAM1
14angiogenesisGO:0015259.2VEGFA, ANGPT2, CCL2, CTGF
15negative regulation of angiogenesisGO:0165259.1CCL2, ANGPT2, CXCL10, SERPINF1
16agingGO:0075689.1CCL2, VCAM1, SERPINF1
17response to hypoxiaGO:0016668.8VEGFA, VCAM1, ANGPT2, CCL2

Molecular functions related to Proliferative Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix bindingGO:0508409.9VEGFA, VTN
2chemoattractant activityGO:0420569.8HGF, VEGFA
3fibronectin bindingGO:0019689.6CTGF, VEGFA
4chemokine activityGO:0080099.4CCL2, CXCL10
5growth factor activityGO:0080839.4CTGF, HGF, VEGFA
6integrin bindingGO:0051789.0VCAM1, VTN, CTGF
7receptor bindingGO:0051028.8CXCL10, ANGPT2, CCL2
8heparin bindingGO:0082018.5CTGF, VTN, CCL2, CXCL10, VEGFA

Products for genes affiliated with Proliferative Diabetic Retinopathy

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  • Antibodies
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Sources for Proliferative Diabetic Retinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet