Proliferative Diabetic Retinopathy malady

MalaCards: Proliferative Diabetic Retinopathy, also known as pigmentary disorder, reticulate, with systemic manifestations, is related to proliferative vitreoretinopathy and vitreoretinopathy. An important gene associated with Proliferative Diabetic Retinopathy is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Telomerase Components in Cell Signaling. The compounds sp 600125 and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include placenta, monocytes and t cells, and related mouse phenotypes are respiratory system and embryogenesis.

Aliases & Descriptions:

proliferative diabetic retinopathy 6 8 32 43 pigmentary disorder, reticulate, with systemic manifestations 43

pdr 6

Diseases related to proliferative diabetic retinopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 988)

id	Related Disease	Score	Top Affiliating Genes
1	proliferative vitreoretinopathy	33.6	VTN, FGF2, MET, CCL4, CCL2, TNC
2	vitreoretinopathy	31.2	VTN, SERPINF1, VEGFA, VCAM1, MIF, FGF2
3	gestational diabetes	30.7	INS, IGFBP1, GHR, PGF, GAD1
4	eales disease	28.9	SERPINF1, VEGFA, IL6, IFNG, TNF, SOD1
5	retinal detachment	27.9	SERPINF1, VEGFA, FGF2, IL6, CCL2, IGF1
6	hemochromatosis	26.9	INS, IL6, CCL2, IGF1, ALB, HLA-DRB1
7	proteinuria	26.8	VTN, SELP, SERPINF1, SERPINE1, VEGFA, VCAM1
8	uveitis	25.5	SELE, SERPINF1, VEGFA, MIF, IL10, IL6
9	amyloidosis	25.2	VTN, MME, MMP9, INS, IL6, APOA4
10	diabetic retinopathy	23.6	PIGF, VTN, SELE, SELP, SETD2, SERPINI1
11	homocysteine	21.1	SELE, SELP, SETD2, SERPINE1, VEGFA, VCAM1
12	type 2 diabetes mellitus	20.9	SELE, SELP, SERPINE1, VEGFA, VCAM1, MTHFR
13	nephropathy	20.2	VTN, SELE, SELP, SERPINF1, SERPINE1, VEGFA
14	retinitis	20.1	PIGF, VTN, SELE, SELP, SETD2, SERPINF1
15	diabetes mellitus	19.3	VTN, SELE, SELP, SERPINE1, VEGFA, VCAM1
16	hypoxia	17.2	PIGF, VTN, SELE, SELP, SETD2, SERPINF1
17	macular holes	14.0	SERPINF1, VEGFA, MIF, ANGPT2, PTGDS, SPTBN5
18	lipodermatosclerosis	14.0	FLT1, ANG, ANGPT2, ANGPT1
19	macular retinal edema	14.0	SERPINF1, VEGFA, CXCL12
20	chorioangioma	13.9	ANGPT2, ANGPT1, SPARC, NRP1
21	functioning pituitary adenoma	13.9	IGF1, GHR, SST, CORT, ADM
22	sorsby fundus dystrophy	13.9	MMP9, ELN, TIMP1, TIMP3
23	doxorubicin induced cardiomyopathy	13.9	MET, EDN1, HGF, EPOR
24	erdheim-chester disease	13.9	CCL4, CCL2, IGF1, SST
25	acid-labile subunit	13.8	IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1, GHR
26	growth retardation with deafness and mental retardation due to igf1 deficiency	13.8	SERPINF1, ANGPT2, ANGPT1, IGFBP1, IGF2, IGFBP2
27	diffuse astrocytoma	13.8	IGFBP2, ICAM1, TNC, GFAP, TIMP3
28	mccune albright syndrome	13.8	IGFBP3, IGF1, GHR, SST, SPARC
29	malignant hypertension	13.8	EDN1, ACE, AGT, ADM
30	ovarian cyst	13.8	VEGFA, MMP2, MMP9, IGFBP2, IGF1, ADM
31	microcystic meningioma	13.8	VEGFA, MMP2, MMP9, FLT1, TIMP1, TIMP2
32	hepatocellular carcinoma (fibrolamellar variant)	13.8	MMP2, MMP9, MET, HGF
33	retinal vascular disease	13.8	VEGFA, MTHFR, NRP1
34	uterine fibroid	13.8	IGFBP1, IGF2, IGF1, CYR61, CTGF, THBS1
35	refractive error	13.8	MMP2, MMP9, MET, TIMP1, TIMP2, TIMP3
36	arteriosclerosis obliterans	13.8	SELP, VCAM1, FGF2, ICAM1, PF4, EDN1
37	growth disorders	13.7	IGF2, IGFBP3, IGF1, GHR
38	chronic myocardial ischemia	13.7	VEGFA, FGF2, ANGPT1, PLG, NOS3
39	gilbert syndrome	13.7	SELP, VEGFA, KDR, IGF1, HIF1A
40	lung giant cell carcinoma	13.7	MMP2, IL8, TIMP1, TIMP2
41	vernal keratoconjunctivitis	13.7	VCAM1, MMP9, IL8, ICAM1
42	lymphedema	13.7	VEGFA, VCAM1, KDR, MET, ANGPT2, ELN
43	osteogenesis imperfecta	13.7	SERPINF1, IGFBP3, IGF1, LOX, TNC, SPARC
44	papillary renal cell carcinoma	13.7	VEGFA, KDR, MME, MET, IGFBP2, IGFBP3
45	middle ear cholesteatoma	13.7	MMP9, FGF2, ICAM1, HIF1A, TGFA
46	skeletal muscle regeneration	13.7	MME, FGF2, IGF2, IGF1, CXCL12
47	insulin-like growth factor 1 resistance to	13.7	IGF2, IGFBP3, IGF1
48	acute mountain sickness	13.7	VEGFA, FLT1, NOS3, EDN1, ACE, HIF1A
49	pilocytic astrocytoma	13.7	VEGFA, KDR, FLT1, TNC, GFAP, TIMP1
50	vascular malformations	13.7	VEGFA, MMP2, MMP9, FGF2, ANGPT1, CCL2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to proliferative diabetic retinopathy:

²²

MGI Mouse Phenotypes related to proliferative diabetic retinopathy:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	SELP, ELN, PGF, GAD1
2	embryogenesis phenotype	MP:0005380	10.0	GAD1, EPOR, EPHB4, SETD2, MET, APLN
3	craniofacial phenotype	MP:0005382	10.0	HSPG2, SP1, NRP1, EDN1, GAD1
4	endocrine/exocrine gland phenotype	MP:0005379	9.9	LTA, CORT, GHR, IFNG
5	hematopoietic system phenotype	MP:0005397	9.9	MIF, FGF2, IGF2, HLA-DQB1, SPARC, PRDX1
6	renal/urinary system phenotype	MP:0005367	9.4	HIF1A, AGT, THBS1, TGFB2, NPPA, ADM
7	integument phenotype	MP:0010771	9.3	F3, TNFRSF1A, PTGDS, SP1, TGFA, ROBO4
8	no phenotypic analysis	MP:0003012	9.2	EPOR, ROBO4, PLXDC1, SST, IGF2, MET
9	limbs/digits/tail phenotype	MP:0005371	8.5	SP1, CTGF, LTA, HFE, THBS1, TGFB2
10	liver/biliary system phenotype	MP:0005370	7.9	HIF1A, AGT, SOD1, ADM, EPO, NOS3
11	skeleton phenotype	MP:0005390	7.7	VEGFA, KDR, MTHFR, JUN, MMP2, MMP9
12	immune system phenotype	MP:0005387	7.6	ADORA2A, ADM, EPOR, PGF, IFNG, HSPG2
13	digestive/alimentary phenotype	MP:0005381	7.6	IFNG, HSPG2, SST, CTGF, PLG, NOS3
14	reproductive system phenotype	MP:0005389	7.3	TNF, TNFRSF1A, PLG, AGT, TIMP1, TIMP3
15	nervous system phenotype	MP:0003631	7.1	PLG, LTA, EDN1, HIF1A, AGT, TIMP2
16	normal phenotype	MP:0002873	7.1	TNC, SST, CTGF, CORT, HIF1A, HFE
17	adipose tissue phenotype	MP:0005375	7.0	NOS3, ACE, AGT, TGFA, TGFB1, PGF
18	growth/size phenotype	MP:0005378	6.5	GHR, SST, SP1, CTGF, NRP1, PLG
19	tumorigenesis	MP:0002006	6.4	TNFRSF1A, PTGDS, SPARC, PLG, ACE, HIF1A
20	mortality/aging	MP:0010768	6.2	SELE, F3, HSPG2, AKR1B1, GHR, HLA-DQB1
21	behavior/neurological phenotype	MP:0005386	5.3	GAD1, SELE, SELP, SERPINI1, KDR, JUN
22	muscle phenotype	MP:0005369	4.8	VEGFA, KDR, MMP2, MMP9, FLT1, FGF2
23	cellular phenotype	MP:0005384	3.9	IFNG, TGFB1, TGFB2, PRDX1, CXCL10, CXCL12
24	vision/eye phenotype	MP:0005391	3.6	SELE, SELP, SERPINF1, VEGFA, F3, HSPG2
25	homeostasis/metabolism phenotype	MP:0005376	3.1	VTN, APLN, APLNR, APOA4, ANGPT2, CCL2
26	cardiovascular system phenotype	MP:0005385	2.1	SELE, APLN, APLNR, APOA4, ANGPT2, ANGPT1

Articles related to proliferative diabetic retinopathy:

(show top 50)    (show all 142)

id	Title	Authors	Year	Affiliating Genes
1	Lipopolysaccharide-binding protein and soluble CD14 i n the vitreous fluid of patients with proliferative diabetic retinopathy. (20175275)	HernA!ndez C.... SimA^ R.	2010	LBP
2	Apelin in plasma and vitreous and in fibrovascular re tinal membranes of patients with proliferative diabetic retinopathy. (20220056)	Tao Y.... Jonas J.B.	2010	APLNR, APLN
3	Roles of endothelin-1 and selected proinflammatory cy tokines in the pathogenesis of proliferative diabetic retinopathy: Analysis of vitreous samples. (20015663)	Adamiec-Mroczek J.... Misiuk-HojA8o M.	2010	TNF, IL6, EDN1
4	Dose of intravitreal bevacizumab (Avastin) used as pr eoperative adjunct therapy for proliferative diabetic retinopathy. (20453802)	Hattori T.... Yuzawa M.	2010	VEGFA
5	Homocysteine levels in the vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment: its modulating role on lysyl oxidase. (19369240)	Coral K.... Rupak R.	2009	ELN, LOX
6	Expression of Robo4 in the fibrovascular membranes fr om patients with proliferative diabetic retinopathy and its role in RF/6A and R PE cells. (19495426)	Huang L.... Yan Z.	2009	ROBO4
7	The expression of vascular endothelial growth factor of vitreous in patients with proliferative diabetic retinopathy (19575912)	Yan H.... Xu Y.H.	2009	VEGFA
8	Proliferative diabetic retinopathy-The influence of diabetes control on the activation of the intraocular molecule system. (19237221)	Adamiec-Mroczek J.... Misiuk-HojA8o M.	2009	ICAM1, SELE, VCAM1
9	Insulin may cause deterioration of proliferative diabetic retinopathy. (19027244)	Zhang P.... Wang Y.	2009	VEGFA, SETD2
10	Vitreous mediators after intravitreal bevacizumab or triamcinolone acetonide in eyes with proliferative diabetic retinopathy. (19410951)	Arimura N.... Sakamoto T.	2009	TNF, VEGFA, IL10
11	TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy. (18316703)	Yamaji Y.... Ishibashi T.	2008	PLXDC1
12	Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy. (18552985)	Beranek M.... Vasku A.	2008	MMP2, MMP9
13	K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes. (18942221)	Petrovic M.G.... Petrovic D.	2008	ICAM1
14	Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy. (18718666)	Matsunaga N.... Hara H.	2008	SERPINF1
15	Functional vascular endothelial growth factor -634G>C SNP is associated with proliferative diabetic retinopathy: a case-control study in a Brazilian population of European ancestry. (17259494)	Errera F.I.... Passos-Bueno M.R.	2007	VEGFA
16	Expression of erythropoietin receptor in human epiretinal membrane of proliferative diabetic retinopathy. (17522145)	Kase S.... Ohno S.	2007	EPOR
17	Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. (17194635)	Abu El-Asrar A.M.... Van Damme J.	2006	CCL2
18	Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy. (16943769)	Hara H.... Kiuchi K.	2006	MME
19	Expression of pigment epithelium-derived factor and vascular endothelial growth factor in fibrovascular membranes from patients with proliferative diabetic retinopathy. (16604386)	Matsuoka M.... Matsumura M.	2006	VEGFA, SERPINF1
20	Differential expression of vitreous proteins in proliferative diabetic retinopathy. (16531280)	Kim S.J.... Kim Y.	2006	PTGDS, APOA4, SPTBN5
21	Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. (16120858)	Watanabe D.... Takagi H.	2005	VEGFA, EPO
22	Vascular endothelial growth factor levels in vitreous and serum of patients with either proliferative diabetic retinopathy or proliferative vitreoretinopathy. (15990461)	Sydorova M.... Lee M.S.	2005	VEGFA
23	Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. (15767056)	Watanabe D.... Takagi H.	2005	VEGFA, ANGPT2
24	Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects. (16043736)	Hernandez C.... Simo R.	2005	SST, CORT
25	Risk evaluation of outcome of vitreous surgery for proliferative diabetic retinopathy based on vitreous level of vascular endothelial growth factor and angiotensin II. (15258026)	Funatsu H.... Hori S.	2004	VEGFA, AGT
26	A hemochromatosis-causing mutation C282Y is a risk factor for proliferative diabetic retinopathy in Caucasians with type 2 diabetes. (14618419)	Peterlin B.... Petrovic D.	2003	HFE
27	Effect of a growth hormone receptor antagonist on proliferative diabetic retinopathy. (12466154)	Chantelau E.	2002	GHR
28	Free insulin growth factor-I and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy. (12208249)	SimA^ R.... HernA!ndez C.	2002	IGF1, VEGFA
29	Polymorphism R25P in the gene encoding transforming growth factor-beta (TGF-beta1) is a newly identified risk factor for proliferative diabetic retinopathy. (11992481)	Beranek M.... Vacha J.	2002	TGFB1
30	Nitric oxide and vascular endothelial growth factor concentrations are increased but not related in vitreous fluid of patients with proliferative diabetic retinopathy. (12147146)	HernA!ndez C.... SimA^ R.	2002	VEGFA
31	Angiotensin converting enzyme inhibiting therapy is associated with lower vitreous vascular endothelial growth factor concentrations in patients with proliferative diabetic retinopathy. (11935151)	Hogeboom van Buggenum I.M.... Tangelder G.J.	2002	VEGFA
32	Vitreous levels of insulin-like growth factor-I in patients with proliferative diabetic retinopathy. (11910526)	Inokuchi N.... Nakamura K.	2001	IGF1
33	Anti-angiogenic therapy of proliferative diabetic retinopathy. (11336594)	Danis R.P.... Pratt L.	2001	AKR1B1, DYT10
34	Monocyte chemotactic protein-1 in the vitreous of patients with proliferative diabetic retinopathy. (11741107)	Mitamura Y.... Nishihira J.	2001	CCL2
35	The effect of a growth hormone receptor antagonist drug on proliferative diabetic retinopathy. (11733269)		2001	GHR
36	Vitreous levels of IGF-I, IGF binding protein 1, and IGF binding protein 3 in proliferative diabetic retinopathy: a case-control study. (10857973)	Burgos R.... SimA^ R.	2000	IGF1, IGFBP3, IGFBP1
37	Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy. (10826517)	Freyberger H.... Derwahl M.	2000	VEGFA, IGF2, PF4
38	Cytokines in the vitreous fluid of patients with pro liferative diabetic retinopathy--vascular endothelial growth factor and platele t-derived growth factor are elevated in proliferative diabetic retinopathy (11081306)	Endo H.... Shiota H.	2000	VEGFA
39	Elevated vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. (12579655)	Deng J.... Gao R.	1999	VEGFA
40	Platelet expression of tumour necrosis factor-alpha (TNF-alpha), TNF receptors and intercellular adhesion molecule-1 (ICAM-1) in patients with proliferative diabetic retinopathy. (10540181)	Limb G.A.... Shilling J.	1999	ICAM1, TNFRSF1A
41	Interferon-induced protein 10 and interleukin 8. C-X-C chemokines present in proliferative diabetic retinopathy. (9869787)	Elner S.G.... Elner V.M.	1998	IL8, CXCL10
42	Increased expression of placenta growth factor in proliferative diabetic retinopathy. (9461127)	Khaliq A.... Boulton M.	1998	VEGFA, PIGF
43	Hepatocyte growth factor in vitreous fluid of patients with proliferative diabetic retinopathy and other retinal disorders. (9773744)	Katsura Y.... Matsuoka T.	1998	HGF
44	Immunodetection of vascular endothelial growth factor in the vitreous of eyes with proliferative diabetic retinopathy (8900585)	Ozaki H.... Matsuoka Y.	1996	VEGFA
45	Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy. (8703862)	Pe'er J.... Keshet E.	1996	VEGFA
46	Distribution of TNF alpha and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy. (8814750)	Limb G.A.... Dumonde D.C.	1996	SELP, VCAM1
47	Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy. (7536680)	Casaroli Marano R.P.... VilarA^ S.	1995	VTN
48	Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathy. (7947554)	Patel B.... Boulton M.	1994	TGFA
49	Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. (7980139)	Malecaze F.... Plouet J.	1994	VEGFA
50	Basic fibroblast growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. (1693499)	Sivalingam A.... Donoso L.	1990	FGF2

Genes related to proliferative diabetic retinopathy according to GeneCards:

(show top 50)    (show all 103)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
2	PTGDS	prostaglandin D2 synthase 21kDa (brain)	11.0	Publications
3	CTGF	connective tissue growth factor	11.0	Publications
4	ANGPT2	angiopoietin 2	11.0	Publications
5	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
6	VEGFA	vascular endothelial growth factor A	11.0	Publications
7	EPHB4	EPH receptor B4	11.0
8	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
9	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
10	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0
11	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
12	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
13	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
14	VTN	vitronectin	11.0	Publications
15	ADM	adrenomedullin	11.0
16	GHR	growth hormone receptor	11.0	Publications
17	GFAP	glial fibrillary acidic protein	11.0
18	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
19	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
20	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
21	SST	somatostatin	11.0	Publications
22	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
23	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
24	ICAM1	intercellular adhesion molecule 1	11.0	Publications
25	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
26	THBS1	thrombospondin 1	11.0
27	TGFB2	transforming growth factor, beta 2	11.0	Publications
28	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
29	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
30	NRP1	neuropilin 1	11.0	Publications
31	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
32	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
33	ANGPT1	angiopoietin 1	11.0
34	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
35	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
36	EDN1	endothelin 1	11.0	Publications
37	ADAMTSL1	ADAMTS-like 1	11.0
38	IL8	interleukin 8	11.0	Publications
39	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
40	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
41	PRR4	proline rich 4 (lacrimal)	11.0
42	VASH1	vasohibin 1	11.0	Publications
43	CORT	cortistatin	11.0	Publications
44	ROBO4	roundabout, axon guidance receptor, homolog 4 (Drosophila)	11.0	Publications
45	SPTBN5	spectrin, beta, non-erythrocytic 5	11.0	Publications
46	FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	11.0	Publications
47	NAA15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	11.0	Expressions, Publications
48	PIGF	phosphatidylinositol glycan anchor biosynthesis, class F	11.0	Publications
49	APLNR	apelin receptor	11.0	Publications
50	PLXDC1	plexin domain containing 1	11.0	Publications, Expressions

Pathways related to proliferative diabetic retinopathy according to GeneDecks:

(show top 50)    (show all 141)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.4	PGF, CTGF, IGF1
2	Telomerase Components in Cell Signaling36	10.1	HGF, PGF, NUDT6, CXCL12, TGFA, TIMP3
3	Breast Cancer Regulation by Stathmin136	10.1	FGF2, TIMP3, TGFA, HGF, NUDT6, TGFB2
4	CREB Pathway36	10.0	TIMP3, NRP1, IGF1, IGF2, KDR, TGFB2
5	PTEN Pathway36	9.9	HGF, PGF, NUDT6, TIMP3, ELN, NRP1
6	Ras Pathway36	9.5	TIMP3, TIMP2, TIMP1, CTGF, IGF2, MET
7	Endothelin-1 Signaling Pathway36	9.4	EPOR, EPHB4, CXCL12, CXCL10, EDN1, PF4
8	IP3 Pathway36	9.2	HGF, PGF, NUDT6, CXCL12, TGFB2, TGFB1
9	eIF2 Pathway36	9.0	TIMP1, CTGF, IGF1, IGF2, IL6, MET
10	Angiogenesis3	9.0	MMP2, KDR, MMP9, FLT1, TGFB2, TGFB1
11	eNOS Signaling36	8.9	TGFB2, TGFB1, TGFA, TIMP2, TIMP1, NOS3
12	GSK3 Signaling36	8.8	PGF, NUDT6, CXCL12, TGFB2, TGFB1, TGFA
13	ILK Signaling36	8.6	TIMP2, TIMP1, HIF1A, ELN, CTGF, TNFRSF1A
14	ERK5 Signaling36	8.6	HGF, PGF, NUDT6, CXCL12, TGFB2, TGFB1
15	p53 Mediated Apoptosis36	8.6	NUDT6, KDR, FLT1, FGF2, CXCL12, TGFB2
16	Mitochondrial Apoptosis36	8.6	TIMP1, NRP1, CTGF, IGF1, IGF2, IL6
17	14-3-3 Induced Intracellular Signaling36	8.6	NUDT6, TGFB2, TGFB1, TIMP3, TIMP1, CTGF
18	Nuclear Receptor Activation by Vitamin-A36	8.5	TIMP2, TIMP1, NRP1, CTGF, IGF1, IGF2
19	Nanog in Mammalian ESC Pluripotency36	8.5	TGFA, TIMP3, TIMP2, TIMP1, CTGF, IGF1
20	MIF Regulation of Innate Immune Cells36	8.5	HGF, CXCL12, CXCL10, LTA, PF4, TNF
21	Akt Signaling36	8.4	LTA, PF4, CTGF, TNFRSF1A, TNF, CCL2
22	DHA Signaling36	8.4	HGF, PGF, NUDT6, CXCL12, TGFB2, TGFB1
23	mTOR Pathway36	8.3	EPHB4, HGF, PGF, NUDT6, CXCL12, TGFB2
24	Activation of PKA through GPCR36	8.3	EPOR, EPHB4, HGF, PGF, NUDT6, CXCL12
25	JNK Pathway36	8.2	EPOR, PGF, NUDT6, CXCL12, TGFB1, TNFRSF1A
26	Rac1 Pathway36	8.2	TGFB2, TGFB1, TIMP3, TIMP2, TIMP1, NRP1
27	Activation of PKC through GPCR36	8.2	TIMP2, TIMP1, NRP1, CTGF, IGF1, IGF2
28	p70S6K Signaling36	8.1	TIMP2, TIMP1, NRP1, CTGF, IGF1, IGF2
29	NF-KappaB Family Pathway36	8.1	TIMP3, TIMP2, TIMP1, LTA, CTGF, TNFRSF1A
30	NF-KappaB (p50-p65) Pathway36	8.1	HGF, PGF, MET, FGF2, FLT1, KDR
31	Phospholipase-C Pathway36	8.0	HGF, IGF2, IL6, MET, FGF2, FLT1
32	Cellular Apoptosis Pathway36	7.9	HGF, PGF, NUDT6, CXCL12, TGFB2, TGFB1
33	Renin-Angiotensin Pathway36	7.9	IGF2, CCL2, IL6, MET, FGF2, FLT1
34	Molecular Mechanisms of Cancer36	7.9	PF4, CTGF, IGF2, ANGPT1, ANGPT2, IL6
35	Malaria20	7.7	ICAM1, IFNG, CCL2, IL8, IL6, IL10
36	ERK Signaling36	7.7	TGFB1, TGFA, TIMP2, TIMP1, PF4, CTGF
37	NFAT in Immune Response36	7.6	EPOR, EPHB4, HGF, PGF, NUDT6, CXCL12
38	Rheumatoid arthritis20	7.5	PGF, VEGFA, JUN, CXCL12, TGFB2, TGFB1
39	Tec Kinases Signaling36	7.5	EPOR, HGF, PGF, NUDT6, CXCL12, TGFB2
40	Estrogen Pathway36	7.5	IGF1, IGF2, IL6, MET, FGF2, FLT1
41	Apoptotic Pathways in Synovial Fibroblasts36	7.3	HGF, PGF, NUDT6, CXCL12, TGFB2, TGFB1
42	TGF-Beta Pathway36	7.2	TGFB2, IL10, MET, FGF2, FLT1, JUN
43	PAK Pathway36	7.1	NRP1, CTGF, TNF, IGF1, IGF2, CCL2
44	Rho Family GTPases36	6.9	FLT1, JUN, KDR, FGF2, LTA, PF4
45	MAPK Signaling36	6.9	PGF, HSPG2, IGF1, IGF2, IL6, MET
46	MAPK Family Pathway36	6.8	TGFB2, IL8, IL6, IL10, MET, FGF2
47	p38 Signaling36	6.8	FGF2, FLT1, KDR, CTGF, SP1, TNFRSF1A
48	Cytokine-cytokine receptor interaction20	6.8	CXCL10, TGFB2, TGFB1, LTA, PF4, TNFRSF1A
49	Antioxidant Action of Vitamin-C36	6.6	TIMP3, TIMP2, TIMP1, LTA, PF4, NRP1
50	JAK-STAT Pathway36	6.1	EPOR, EPO, EPHB4, HGF, PGF, NUDT6

Compounds related to proliferative diabetic retinopathy according to GeneDecks:

(show top 50)    (show all 462)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.9	CTGF, VCAM1
2	c-peptide32	10.5	GAD1, PF4, GHR, IGFBP2, IGF2
3	aprotinin32 9 9	12.2	TIMP2, AGT, PF4, PLG, IGF1, MMP9
4	egcg32	10.0	SOD1, TGFB2, TIMP2, TIMP1, SP1, HSPG2
5	p00232	9.8	ADM, TIMP2, TIMP1, PF4, CTGF, TNFRSF1A
6	aspartate32	9.8	HGF, ADORA2A, ADAMTSL1, GFAP, HFE, ELN
7	apocynin32	9.8	VCAM1, SETD2, SELE, JUN, ICAM1, DYT10
8	captopril32 42 9 9	12.6	CTGF, ALB, F3, MMP2, PLG, ACE
9	pioglitazone32 9 9	11.5	VEGFA, SOD3, TIMP2, TIMP1, CTGF, IGFBP1
10	vitamin a32 9 18 9	12.5	HGF, SOD1, TGFB2, ELN, PTGDS, GHR
11	fmlp32	9.4	TNF, HSPG2, ICAM1, CCL2, VCAM1, SELP
12	heparan sulfate32 18	10.4	FGF2, KDR, SERPINE1, VTN, MET, CCL4
13	pge232	9.4	CXCL10, SETD2, SELE, VTN, VCAM1, MME
14	octreotide32 42 9 9	12.3	IFNA2, IGF1, IGFBP3, IGF2, IGFBP1, INS
15	gnrh32	9.3	SERPINE1, MME, INS, TGFA, SP1, GHR
16	h2o232	9.2	GAD1, ADM, ADAMTSL1, SOD3, PRDX1, AGT
17	epinephrine32 9 18 9	11.9	TGFA, AGT, SP1, AKR1B1, F3, IGFBP3
18	rapamycin32 42	9.8	KDR, VEGFA, NPPA, AGT, ELN, CTGF
19	doxorubicin32 34 9 9	11.8	EPOR, HGF, PRDX1, TGFA, THBS1, HIF1A
20	forskolin32 42 9 9	11.5	TNFRSF1A, HSPG2, IGFBP2, IGF2, IGFBP1, CCL4
21	folate32	8.4	SOD3, TGFA, TIMP1, NOS3, SP1, CYR61
22	paclitaxel32 34 9 9	11.4	HGF, TGFB1, TGFA, THBS1, TIMP2, VEGFA
23	testosterone32 9 18 9	11.3	ELN, SPARC, SP1, SST, PTGDS, TNFRSF1A
24	infliximab32 9 9	10.3	CXCL10, TIMP1, LTA, TNFRSF1A, TNF, IFNG
25	losartan32 34 9 9	11.3	HGF, ADM, NPPA, SOD3, TGFB1, TIMP2
26	heparin32 9 18 9	11.3	TIMP3, APOA4, MET, FLT1, LBP, SERPINE1
27	sb 20358032 42	9.1	AGT, VEGFA, SETD2, SELE, VCAM1, MMP2
28	diphenyleneiodonium32	8.1	VCAM1, VEGFA, SERPINF1, SETD2, SOD1, TGFB1
29	thalidomide32 42 9 9	11.1	EPO, HGF, THBS1, PLG, TNFRSF1A, TNF
30	15-deoxy-delta-12,14-prostaglandin j232	8.0	NOS3, CTGF, PTGDS, TNF, IFNG, CCL2
31	pentoxifylline32 9 9	10.0	SELP, VCAM1, MMP2, ADORA2A, LTA, TNF
32	fibrinogen32	7.9	ADAMTSL1, ANGPT2, APOA4, IL6, INS, LBP
33	curcumin32	7.9	MMP9, MMP2, JUN, VCAM1, VEGFA, VTN
34	arginine32	7.9	TIMP1, INS, MME, VTN, CCL2, IGFBP1
35	histamine32 18	8.8	TGFA, TIMP1, HIF1A, ELN, EDN1, PF4
36	prednisolone32 9 9	9.7	IL6, IL10, FGF2, MMP2, VCAM1, CCL4
37	8-isoprostane32	7.6	IL6, IL10, INS, MMP9, MMP2, VCAM1
38	glutamate32	7.6	DYT10, TNFRSF1A, TNC, IGFBP3, IGF2, IGFBP1
39	cysteine32	7.4	NRP1, MTHFR, KDR, SERPINF1, SELP, VTN
40	cholesterol32 9 18 9	10.3	GAD1, ADM, ADORA2A, ADAMTSL1, SOD3, CXCL12
41	hydrocortisone32 9 9	9.1	HGF, FGF2, INS, MIF, FLT1, MMP2
42	ly29400232	7.1	EPOR, TGFB1, THBS1, TIMP3, TIMP2, VEGFA
43	cyclosporin a32 42	8.0	GAD1, HGF, ADM, ADAMTSL1, NPPA, TGFB2
44	tacrolimus32 34 9 9	10.0	SPARC, TNF, F3, IFNG, CCL4, IL10
45	prostacyclin32	6.5	HGF, ADM, ADORA2A, TNF, HSPG2, F3
46	alanine32	6.3	EPOR, HGF, AKR1B1, HSPG2, ALB, F3
47	methotrexate32 34 42 9 9	10.3	TNFRSF1A, TNF, HLA-DRB1, ALB, IGFBP3, IL6
48	pdtc32	6.1	IL6, MET, MMP9, MMP2, JUN, VCAM1
49	indomethacin32 9 9	7.6	HGF, ADM, PGF, SOD1, TGFB2, TGFB1
50	dexamethasone32 42 34 9 9	8.6	HGF, ADM, ADAMTSL1, CXCL12, CXCL10, PRDX1

Cellular components related to proliferative diabetic retinopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basement membrane	GO:005604	9.7	TGFB2, TIMP3, TIMP2, TIMP1, SPARC, HSPG2
2	cytoplasmic vesicle	GO:031410	9.7	APLNR, IGFBP2, NRP1, HFE, TGFA, SOD1
3	extracellular matrix	GO:031012	9.4	SOD3, SOD1, TGFB2, THBS1, TIMP3, TNC
4	platelet alpha granule lumen	GO:031093	9.0	SERPINE1, VEGFA, IGF1, ALB, SPARC, PLG
5	proteinaceous extracellular matrix	GO:005578	9.0	ADAMTSL1, TGFB1, ELN, CTGF, SPARC, TNC
6	cell surface	GO:009986	8.9	TIMP2, TGFA, TGFB1, TGFB2, EPHB4, TNFRSF1A
7	neuronal cell body	GO:043025	8.9	ADORA2A, SOD1, TGFB2, TGFB1, SST, GHR
8	external side of plasma membrane	GO:009897	8.9	ROBO4, CXCL12, CXCL10, THBS1, ACE, TNF
9	extracellular region	GO:005576	4.0	SERPINF1, CCL4, CCL2, IGFBP1, IGF2, IGFBP2
10	extracellular space	GO:005615	2.6	VTN, IL6, IL8, APOA4, ANG, ANGPT2

Biological processes related to proliferative diabetic retinopathy according to GeneDecks:

(show top 50)    (show all 82)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of angiogenesis	GO:016525	10.5	VASH1, CXCL10, THBS1, PF4, CCL2, ANGPT2
2	positive regulation of endothelial cell migration	GO:010595	10.5	KDR, ANGPT1, NRP1, EDN1, VEGFA, THBS1
3	cellular response to interleukin-1	GO:071347	10.5	HIF1A, EDN1, ICAM1, CCL2, IL8, MMP9
4	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.4	FLT1, CCL2, NRP1, PGF, KDR, VEGFA
5	response to amino acid stimulus	GO:043200	10.4	CTGF, NOS3, EDN1, TIMP3, ICAM1, SST
6	blood vessel remodeling	GO:001974	10.1	IGF1, NOS3, AGT, TGFB2, ELN
7	blood circulation	GO:008015	10.1	EPO, ADM, ADORA2A, CXCL12, CXCL10, ELN
8	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.0	KDR, FLT1, INS, ANGPT1, TGFB2, IGF1
9	response to organic cyclic compound	GO:014070	10.0	TIMP3, MET, SELP, JUN, ANGPT2, ICAM1
10	positive regulation of angiogenesis	GO:045766	9.8	TNFRSF1A, F3, ANGPT2, FGF2, FLT1, MMP9
11	extracellular matrix organization	GO:030198	9.8	GFAP, MMP2, TIMP2, TIMP1, ELN, AGT
12	organ regeneration	GO:031100	9.8	TGFB1, HGF, ADM, CXCL12, CCL2, ANGPT1
13	activation of MAPK activity	GO:000187	9.8	GHR, SOD1, MET, TGFA, THBS1, HGF
14	positive regulation of endothelial cell proliferation	GO:001938	9.8	PGF, CXCL12, JUN, HIF1A, NRP1, F3
15	response to heat	GO:009408	9.7	CCL2, SST, CXCL12, SOD1, NOS3, MMP9
16	response to wounding	GO:009611	9.7	TNC, GFAP, TGFB1, TGFB2, ADM, MET
17	negative regulation of blood vessel endothelial cell migration	GO:043537	9.7	VASH1, FGF2, ANGPT2, THBS1, TGFB1
18	positive regulation of mitosis	GO:045840	9.7	TGFA, TNF, IGF2, MET, INS, IGF1
19	response to mechanical stimulus	GO:009612	9.7	NOS3, CXCL12, TIMP3, F3, IGFBP2, JUN
20	signal transduction	GO:007165	9.6	ANGPT2, IGFBP1, CCL2, CCL4, APLN, IL8
21	positive regulation of blood vessel endothelial cell migration	GO:043536	9.6	VEGFA, FGF2, ANGPT1, THBS1, TGFB1
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	ANGPT1, IL6, AGT, NRP1, GHR, IGF1
23	positive regulation of smooth muscle cell proliferation	GO:048661	9.5	JUN, FLT1, HIF1A, EDN1, TNF, IGF1
24	positive regulation of cell division	GO:051781	9.5	FGF2, VEGFA, PGF, TGFB2, TGFB1, TGFA
25	female pregnancy	GO:007565	9.5	PGF, TGFB1, HFE, IGFBP2, FLT1, TGFB2
26	response to estradiol stimulus	GO:032355	9.4	CTGF, NOS3, TGFB2, IGFBP2, GHR, F3
27	response to lipopolysaccharide	GO:032496	9.4	SELP, TNFRSF1A, F3, SPARC, LTA, EDN1
28	response to radiation	GO:009314	9.4	TGFB2, CXCL12, JUN, TGFB1, MMP9, ANGPT2
29	positive regulation of MAPK cascade	GO:043410	9.4	KDR, FLT1, INS, IL6, IGFBP3, IGF1
30	response to ethanol	GO:045471	9.2	NOS3, ICAM1, TNFRSF1A, CCL2, SOD1, SPARC
31	cellular response to lipopolysaccharide	GO:071222	9.2	SERPINE1, ICAM1, IFNG, CCL2, IL8, LBP
32	response to glucocorticoid stimulus	GO:051384	9.2	IL10, SERPINE1, SERPINF1, ADM, CCL2, IGFBP2
33	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.1	MET, TGFB1, MIF, VEGFA, IL6, ANGPT1
34	cell-cell signaling	GO:007267	9.1	EDN1, LTA, AGT, ADM, INS, NRP1
35	positive regulation of cell migration	GO:030335	9.0	KDR, CYR61, FLT1, INS, TGFB1, THBS1
36	aging	GO:007568	8.9	SERPINF1, VCAM1, JUN, CCL2, IGFBP2, F3
37	negative regulation of growth of symbiont in host	GO:044130	8.9	IFNG, IL10, LBP, TNF, LTA
38	platelet degranulation	GO:002576	8.8	SELP, SERPINE1, VEGFA, IGF1, ALB, SPARC
39	positive regulation of protein kinase B signaling cascade	GO:051897	8.8	INS, TGFB1, ANGPT1, TNF, IGF1, F3
40	response to hypoxia	GO:001666	8.8	CCL2, ANGPT1, ANGPT2, TNF, NOS3, CXCL12
41	anti-apoptosis	GO:006916	8.7	IL10, ANGPT1, CCL2, IGF1, F3, TNF
42	angiogenesis	GO:001525	8.6	SETD2, NAA15, VASH1, KDR, JUN, MMP2
43	negative regulation of apoptotic process	GO:043066	8.5	INS, KDR, SERPINE1, VEGFA, MIF, CYR61
44	cytokine-mediated signaling pathway	GO:019221	8.3	VCAM1, TNFRSF1A, HLA-DRB1, CCL2, ICAM1, IL6
45	platelet activation	GO:030168	8.3	PLG, SPARC, ALB, SELP, SERPINE1, VEGFA
46	positive regulation of cell proliferation	GO:008284	8.2	IGF2, IGF1, EPO, INS, FLT1, VEGFA
47	negative regulation of cell proliferation	GO:008285	8.2	TNF, TIMP2, AGT, NOS3, PLG, SST
48	blood coagulation	GO:007596	8.1	IFNA2, IGF1, TGFB2, F3, HGF, ADORA2A
49	inflammatory response	GO:006954	7.9	SELE, SELP, MIF, IL10, IFNA2, TNF
50	response to drug	GO:042493	6.9	EDN1, LTA, NOS3, SST, TNF, ICAM1

Molecular functions related to proliferative diabetic retinopathy according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	fibronectin binding	GO:001968	10.5	THBS1, CTGF, IGFBP3, MMP9, VEGFA
2	integrin binding	GO:005178	10.3	THBS1, TIMP2, GFAP, CTGF, CYR61, ICAM1
3	chemokine activity	GO:008009	10.2	CXCL12, CXCL10, PF4, CCL2, CCL4, IL8
4	cell surface binding	GO:043498	10.2	PLG, F3, ICAM1, MIF, LBP, VEGFA
5	heparin binding	GO:008201	10.2	PGF, SOD3, THBS1, PF4, NRP1, CTGF
6	insulin-like growth factor binding	GO:005520	10.1	CTGF, CYR61, IGFBP3, IGFBP1
7	extracellular matrix binding	GO:050840	10.1	ELN, SPARC, CYR61, VEGFA
8	receptor binding	GO:005102	9.7	LTA, TGFB2, CXCL10, CXCL12, NPPA, ADM
9	hormone activity	GO:005179	9.4	EPO, ADM, NPPA, AGT, EDN1, SST
10	eukaryotic cell surface binding	GO:043499	9.3	EPO, TGFB1, THBS1, APOA4, SELP
11	protease binding	GO:002020	9.3	SERPINE1, INS, F3, TNF, TNFRSF1A
12	cytokine activity	GO:005125	8.2	TGFB2, EDN1, LTA, TNF, IFNG, IFNA2
13	growth factor activity	GO:008083	8.1	TGFB1, TGFB2, CXCL12, NUDT6, PGF, HGF
14	protein binding	GO:005515	3.6	GAD1, HFE, HIF1A, ELN, ACE, NOS3