MCID: PRL003
MIFTS: 45

Proliferative Glomerulonephritis malady

Summaries for Proliferative Glomerulonephritis

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MalaCards based summary: Proliferative Glomerulonephritis is related to glomerulonephritis and nephritis. An important gene associated with Proliferative Glomerulonephritis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Immune response IL 23 signaling pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds ramipril and olmesartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and endothelial, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Proliferative Glomerulonephritis

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 57SNOMED-CT, 40NCIt
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Proliferative Glomerulonephritis, Aliases & Descriptions:

Name: Proliferative Glomerulonephritis 10 45 62


External Ids:

Disease Ontology10 DOID:4778
SNOMED-CT57 441815006
NCIt40 C35281

Related Diseases for Proliferative Glomerulonephritis

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Diseases in the Proliferative Glomerulonephritis family:

Acute Proliferative Glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.0AGTR1, CD79A, CCL2
2nephritis30.9CD79A, CCL2, CXCR3
3systemic lupus erythematosus30.8CXCR3, CCL2, CD79A
4proteinuria30.5CCL2, CD79A, AGTR1
5lupus nephritis30.5CD79A, CCL2, CXCR3
6arthritis30.4AGTR1, CCR1, CCL2, CXCR3
7vasculitis30.4CD79A, CCL2
8rheumatoid arthritis30.3CD79A, CCR1, CCL2, CXCR3
9acute poststreptococcal glomerulonephritis30.2CD79A
10connective tissue disease30.1CCL2, CD79A
11renal fibrosis30.1AGTR1, CCL2
12kidney disease30.1AGTR1, CCL2
13mesangial proliferative glomerulonephritis11.2
14nephrotic syndrome10.6
15acute proliferative glomerulonephritis10.6
16lupus erythematosus10.6
17hepatitis10.5
18hepatitis c virus10.3
19multiple myeloma10.3
20hepatitis c10.3
21cryoglobulinemia10.3
22immune-complex glomerulonephritis10.3
23myeloma10.3
24endotheliitis10.3
25leprosy10.2
26arteriovenous fistula10.2
27antiphospholipid syndrome10.2
28membranoproliferative glomerulonephritis10.2
29endocarditis10.2
30interstitial nephritis10.2
31retinitis10.2
32castleman's disease10.2
33polymyositis10.2
34c1q deficiency10.1
35bacteremia10.1
36chronic lymphocytic leukemia10.1
37crohn's disease10.1
38hemolytic anemia10.1
39leukemia10.1
40mantle cell lymphoma10.1
41myasthenia gravis10.1
42membranous glomerulonephritis10.1
43pharyngitis10.1
44lepromatous leprosy10.1
45autoimmune hemolytic anemia10.1
46aphthous stomatitis10.1
47polymyalgia rheumatica10.1
48polycystic kidney disease10.1
49hepatitis a10.1
50hemolytic-uremic syndrome10.1

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to proliferative glomerulonephritis

Symptoms for Proliferative Glomerulonephritis

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Drugs & Therapeutics for Proliferative Glomerulonephritis

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Drug clinical trials:

Search ClinicalTrials for Proliferative Glomerulonephritis

Search NIH Clinical Center for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

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Anatomical Context for Proliferative Glomerulonephritis

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MalaCards organs/tissues related to Proliferative Glomerulonephritis:

33
Kidney, T cells, Endothelial, Bone marrow, Bone, Spleen, Brain, Lung, Prostate, Monocytes, B cells, Neutrophil

Animal Models for Proliferative Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5AGTR1, CD79A, CCR1, CXCR3
2MP:00053978.5CD79A, CCR1, CCL2, CXCR3
3MP:00053858.1CXCR3, CCL2, CCR1, AGTR1
4MP:00053877.9CXCR3, CCL2, CCR1, CD79A, AGTR1
5MP:00053767.8CXCR3, CCL2, CCR1, CD79A, AGTR1

Publications for Proliferative Glomerulonephritis

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Articles related to Proliferative Glomerulonephritis:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature. (25484532)
2014
2
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. (24701045)
2014
3
Diffuse segmental and pure diffuse global proliferative glomerulonephritis: different patterns of class IV lupus nephritis. (25017669)
2014
4
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
5
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. (24649023)
2013
6
Antiribosomal-P protein antibodies are associated with proliferative glomerulonephritis more strongly than with membranous glomerulonephritis in Japanese patients with systemic lupus erythematosus. (22042098)
2012
7
A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. (23326256)
2012
8
Autosomal dominant polycystic kidney disease with diffuse proliferative glomerulonephritis - an unusual association: a case report and review of the literature. (20429898)
2010
9
Bilateral macular sub-retinal fluid and retinal pigment epithelial detachment associated with type 2 membrano-proliferative glomerulonephritis. (18430038)
2008
10
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. (16334979)
2005
11
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
12
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
13
Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. (12105242)
2002
14
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. (11979343)
2002
15
Expression of complement regulatory proteins in diffuse proliferative glomerulonephritis. (10787010)
2000
16
Growth factor pathways in proliferative glomerulonephritis. (10847321)
2000
17
In situ hybridization in the study of remodeling in proliferative glomerulonephritis. (9502386)
1998
18
Urinary erythrophagocytes in proliferative glomerulonephritis. (9750096)
1998
19
Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. (9239405)
1997
20
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis. (7758332)
1995
21
Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis. (7783409)
1995
22
Alteration of C3 nephritic factor in a patient with membrano-proliferative glomerulonephritis type II. (7891786)
1995
23
Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. (8402004)
1993
24
Platelet-derived growth factor and proliferative glomerulonephritis. (8468932)
1993
25
IgA nephropathy in two HLA-identical brothers and acute, diffuse proliferative glomerulonephritis in the third, HLA-different brother. (1501751)
1992
26
Proliferative glomerulonephritis in mice induced by sea snake (Aipysurus laevis) venom. (1446167)
1992
27
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
28
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
29
Proliferative glomerulonephritis and the activity of lymphocyte DNA transcriptional enzymes. (1821613)
1991
30
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
31
Auricular chondritis and diffuse proliferative glomerulonephritis in primary SjAPgren's syndrome. (2782978)
1989
32
Mixed membranous and proliferative glomerulonephritis in primary SjAPgren's syndrome. (2590814)
1989
33
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
34
Therapeutic effect of cyclosporin A and steroid on serum sickness type nephritis in the rat. 2. Suppressive effect on full-blown proliferative glomerulonephritis. (3063863)
1988
35
Mesangio-proliferative glomerulonephritis associated with Kimura's disease. (3180515)
1988
36
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
37
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. (3549083)
1987
38
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis (PGN) associated with identical HL-A antigens. (3313816)
1986
39
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis, without mesangial IgA deposits (PGN), associated with identical HL-A antigens. (6518679)
1984
40
Activation of platelets in patients with chronic proliferative glomerulonephritis and the nephrotic syndrome. (6459902)
1982
41
Proliferative glomerulonephritis in experimental Leishmania donovani infection of the golden hamster. (7333089)
1981
42
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
43
Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits. (158675)
1979
44
Unusual ultrastructural features in a case of acute diffuse proliferative glomerulonephritis. (527963)
1979
45
Proliferative glomerulonephritis in monoclonal gammopathy. (917180)
1977
46
Serial biopsies in diffuse proliferative glomerulonephritis in adults: an attempt for a better understanding of sporadic acute glomerulonephritis. (4620922)
1973
47
Complement studies in membrano-proliferative glomerulonephritis. (4625395)
1972
48
The relationship of neutrophilic and eosinophilic leukocytes to the glomerular capillary basement membrane in acute proliferative glomerulonephritis. (5136992)
1971
49
Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy. (4186205)
1969
50
Ultrastructural demonstration of injury and perforation of glomerular capillary basement membrane in acute proliferative glomerulonephritis. (4184004)
1969

Variations for Proliferative Glomerulonephritis

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Expression for genes affiliated with Proliferative Glomerulonephritis

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Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for genes affiliated with Proliferative Glomerulonephritis

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Pathways related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.5AGTR1, CCL2
2
Show member pathways
8.9CCR1, CCL2, CXCR3
3
Show member pathways
8.9CCR1, CCL2, CXCR3
4
Show member pathways
8.9CCR1, CXCR3, CCL2
5
Show member pathways
8.9CCL2, CXCR3, CCR1
6
Show member pathways
8.9CXCR3, CCL2, CCR1
7
Show member pathways
Peptide GPCRs38
8.8CXCR3, AGTR1, CCR1
8
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
9
Show member pathways
8.4AGTR1, CXCR3, CCL2, CCR1
10
Show member pathways
8.1CCR1, CCL2, CXCR3, PTPRQ

Compounds for genes affiliated with Proliferative Glomerulonephritis

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Compounds related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1ramipril45 1310.9AGTR1, CD79A
2olmesartan45 30 1311.9AGTR1, CCL2
3sulfasalazine30 45 51 1312.9CD79A, CCL2
4shikonin459.9CCR1, CCL2
5gw966245 3010.9AGTR1, CCL2
6mdms459.9CCR1, CCL2
7valsartan45 61 30 1312.9AGTR1, CCL2
8telmisartan45 30 1311.9AGTR1, CCL2
9irbesartan45 30 51 1312.9CCL2, AGTR1
10candesartan45 51 30 1312.8CCL2, AGTR1
11captopril45 61 51 30 1313.8AGTR1, CD79A
12mcp 1459.8CCL2, CXCR3
138-isoprostane459.8AGTR1, CCL2
14larc459.8CCL2, CXCR3
15methacholine45 51 1311.8CD79A, AGTR1
16ang ii459.8CCL2, AGTR1
17ccl5309.8CXCR3, CCR1
18ccl13309.8CCR1, CXCR3
19ccl7309.8CXCR3, CCR1
20vitamin b12459.7CD79A, CCL2
21groalpha459.7CXCR3, CCL2
22il 10459.7CCL2, CXCR3
23fluvastatin45 51 30 1312.6CCL2, AGTR1
24tarc459.6CXCR3, CCL2
25allergens459.5CXCR3, CD79A
26leukotriene b445 61 2611.5CCR1, CCL2
27losartan45 51 30 1312.5CCL2, AGTR1
28n acetylcysteine459.5CCL2, CD79A, AGTR1
29vitamin d459.4AGTR1, CD79A, CCL2
30fibrinogen459.4CCL2, AGTR1, CD79A
31norepinephrine45 26 1311.4CD79A, CCL2, AGTR1
32tacrolimus45 51 1311.3AGTR1, CD79A, CXCR3
33ccl345 3010.3CXCR3, CCL2, CCR1
34histamine45 30 2611.3CD79A, CCL2, CXCR3
35ccl445 3010.3CXCR3, CCR1, CCL2
36actinomycin d459.3AGTR1, CCR1, CCL2
37rantes459.3CXCR3, CCL2, CCR1
38pravastatin45 51 30 26 1313.2CCL2, AGTR1
39cycloheximide459.2AGTR1, CCL2, CCR1
40pge2458.9CCL2, CCR1, CD79A, CXCR3
41creatinine458.9CXCR3, CCL2, CD79A, AGTR1
42vegf458.9CD79A, CXCR3, AGTR1, CCL2
43arginine458.9CCL2, CD79A, CXCR3, AGTR1
44heparin45 30 26 1311.8AGTR1, CD79A, CCR1, CXCR3
45superoxide45 269.8AGTR1, CCR1, CXCR3, CCL2
46cholesterol45 30 26 1311.8CCL2, AGTR1, CXCR3
47phosphatidylinositol458.8CCL2, AGTR1, CCR1, CXCR3
48nitric oxide45 26 1310.8CCL2, CCR1, AGTR1, CXCR3
49serine458.6CCR1, CXCR3, CCL2, AGTR1
50dexamethasone45 51 30 1311.4AGTR1, CD79A, CXCR3, CCL2, CCR1

GO Terms for genes affiliated with Proliferative Glomerulonephritis

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Cellular components related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CD79A, CCR1, CXCR3

Biological processes related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:00700989.7CCR1, CCL2
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.6CCR1, CCL2
3cellular calcium ion homeostasisGO:00068749.5CCL2, CCR1
4calcium-mediated signalingGO:00197229.3CXCR3, AGTR1
5negative regulation of angiogenesisGO:00165259.1CXCR3, CCL2
6chemotaxisGO:00069359.1CCR1, CCL2, CXCR3
7cell surface receptor signaling pathwayGO:00071669.1CCR1, CCL2, CXCR3
8positive regulation of cytosolic calcium ion concentrationGO:00072049.0AGTR1, CCR1, CXCR3
9inflammatory responseGO:00069549.0CXCR3, CCL2, CCR1
10G-protein coupled receptor signaling pathwayGO:00071869.0CXCR3, CCL2, AGTR1
11cell adhesionGO:00071558.8CXCR3, CCL2, CCR1

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.3CCR1, CXCR3

Products for genes affiliated with Proliferative Glomerulonephritis

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Sources for Proliferative Glomerulonephritis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet