MCID: PRL003
MIFTS: 43

Proliferative Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Proliferative Glomerulonephritis

MalaCards integrated aliases for Proliferative Glomerulonephritis:

Name: Proliferative Glomerulonephritis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4778
NCIt 47 C35281
SNOMED-CT 64 441815006
UMLS 69 C0235618

Summaries for Proliferative Glomerulonephritis

MalaCards based summary : Proliferative Glomerulonephritis is related to lymphoma and legionellosis. An important gene associated with Proliferative Glomerulonephritis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Enalapril and Enalaprilat have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and t cells, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Proliferative Glomerulonephritis

Diseases in the Proliferative Glomerulonephritis family:

Acute Proliferative Glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.1 CD79A IFNG IL4 IL6
2 legionellosis 28.5 CD79A IFNG IL4 IL6
3 rheumatoid arthritis 28.3 CCL2 CD79A IFNG IL4 IL6
4 malaria 27.6 CCL2 CR1 CXCR3 IFNG IL4 IL6
5 systemic lupus erythematosus 27.0 C3 CCL2 CD79A CR1 CXCR3 IFNG
6 diffuse glomerulonephritis 24.0 C3 CCL2 CD79A CFH CR1 CTGF
7 mesangial proliferative glomerulonephritis 12.4
8 acute proliferative glomerulonephritis 12.4
9 c1q deficiency 11.1
10 glomerulonephritis 10.9
11 der kaloustian mcintosh silver syndrome 10.6 C3 CFH
12 rhizomelic chondrodysplasia punctata 10.6 C3 CFH
13 myoclonic astatic epilepsy 10.6 IFNG IL4
14 tang hsi ryu syndrome 10.6 CR1 IFNG
15 malignant renovascular hypertension 10.6 CD79A IFNG
16 eye accommodation disease 10.5 IFNG IL4
17 thelaziasis 10.5 IFNG IL4
18 dumping syndrome 10.5 CD79A IFNG
19 goat milk allergy 10.5 IFNG IL4
20 parametritis 10.5 CFH IFNG
21 hemolytic uremic syndrome, atypical 3 10.5 C3 CR1
22 x-linked intellectual disability, van esch type 10.5 IFNG IL4
23 non-congenital cyst of kidney 10.5 C3 CD79A
24 cholesteatoma of middle ear 10.5 CD79A IFNG
25 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.5 CD79A IFNG
26 acanthoma 10.5 CFH IFNG
27 urethral intrinsic sphincter deficiency 10.5 CCL2 IL4
28 chronic mucocutaneous candidiasis 10.5 C3 CD79A
29 plantar wart 10.5 CD79A IFNG
30 vaginal endometrial stromal sarcoma 10.5 C3 CD79A
31 hypercalcinuria macular coloboma 10.5 IFNG IL4
32 centronuclear myopathy 5 10.5 IFNG IL4
33 cranial nerve malignant neoplasm 10.4 CCL2 CXCR3 IFNG
34 acute gonococcal prostatitis 10.4 IFNG IL4
35 uveitis 10.4 CCL2 CD79A
36 renal tubular acidosis 10.4 CCL2 CXCR3 IFNG
37 partial circumpapillary choroid dystrophy 10.4 C3 CD79A
38 inflammatory bowel disease 3 10.4 CCL2 CXCR3 IFNG
39 schwannoma of ureter 10.4 CCL2 IL6
40 ectropion 10.4 CXCR3 IL4
41 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.4 IFNG IL4
42 hepatic angiomyolipoma 10.4 CCL2 CXCR3 IFNG
43 fibrous histiocytoma 10.4 IFNG IL4
44 spindle cell hemangioma 10.3 IFNG IL4
45 pasteurellosis 10.3 IFNG IL6
46 dermatomycosis 10.3 C3 CD79A
47 hemangioma of spleen 10.3 IFNG IL6
48 herpangina 10.3 IFNG IL6
49 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.3 CCL2 IL6
50 diabetic angiopathy 10.3 CD79A IL4

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to Proliferative Glomerulonephritis

Symptoms & Phenotypes for Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 C3 CD79A CFH CTGF CXCR3 IFNG
2 hematopoietic system MP:0005397 10.01 C3 CD79A CFH CXCR3 IFNG IL4
3 immune system MP:0005387 9.97 C3 CCL2 CD79A CFH CXCR3 IFNG
4 normal MP:0002873 9.7 C3 CD79A CFH CTGF CXCR3 IFNG
5 liver/biliary system MP:0005370 9.65 C3 CD79A IFNG IL4 IL6
6 renal/urinary system MP:0005367 9.5 C3 CD79A CFH CXCR3 IFNG IL4
7 vision/eye MP:0005391 9.1 C3 CFH CTGF IFNG IL4 IL6

Drugs & Therapeutics for Proliferative Glomerulonephritis

Drugs for Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
2
Enalaprilat Approved Phase 4 76420-72-9 6917719
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
5
rituximab Approved Phase 4 174722-31-7 10201696
6
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 134070 5280453
7 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
8 Bone Density Conservation Agents Phase 4,Phase 3
9 Calcium, Dietary Phase 4
10 Immunoglobulin A Phase 4,Phase 3
11 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
12 Micronutrients Phase 4,Phase 3
13 Trace Elements Phase 4,Phase 3
14 Vasoconstrictor Agents Phase 4
15 Vitamins Phase 4,Phase 3
16 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 2
17 Antiemetics Phase 4,Phase 3
18 Antihypertensive Agents Phase 4,Phase 2
19 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
20 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
21 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Autonomic Agents Phase 4,Phase 3
23 Gastrointestinal Agents Phase 4,Phase 3
24 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
25 HIV Protease Inhibitors Phase 4,Phase 2
26 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
27 Hormones Phase 4,Phase 2,Phase 3,Phase 1
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
29 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
30 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
31 Neuroprotective Agents Phase 4,Phase 3
32 Peripheral Nervous System Agents Phase 4,Phase 3
33 Prednisolone acetate Phase 4,Phase 2,Phase 3
34 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
35 Prednisolone phosphate Phase 4,Phase 2,Phase 3
36
protease inhibitors Phase 4,Phase 2
37 Protective Agents Phase 4,Phase 3,Phase 2
38 Adrenocorticotropic Hormone Phase 4
39 beta-endorphin Phase 4
40 Melanocyte-Stimulating Hormones Phase 4
41
Azathioprine Approved Phase 3,Phase 1 446-86-6 2265
42
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
43
Mycophenolate mofetil Approved, Investigational Phase 3,Phase 2 128794-94-5 5281078
44
Mycophenolic acid Approved Phase 3,Phase 2 24280-93-1 446541
45
Leflunomide Approved, Investigational Phase 2, Phase 3 75706-12-6 3899
46
Prednisone Approved, Vet_approved Phase 2, Phase 3, Phase 1 53-03-2 5865
47
Cyclophosphamide Approved, Investigational Phase 3,Phase 1 50-18-0, 6055-19-2 2907
48
Abatacept Approved Phase 2, Phase 3 332348-12-6 10237
49 tannic acid Approved, Nutraceutical Phase 3
50 Anti-Bacterial Agents Phase 3,Phase 2

Interventional clinical trials:

(show all 21)

id Name Status NCT ID Phase Drugs
1 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
2 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
3 Calcitriol in the Treatment of Immunoglobulin A (IgA) Nephropathy Completed NCT00319761 Phase 4 Calcitriol
4 ACTHAR GEL in Patients With Membranous (Class V) Lupus Nephritis Recruiting NCT01926054 Phase 4 Acthar gel
5 Velcade for Proliferative Lupus Nephritis Withdrawn NCT01169857 Phase 4 Velcade
6 Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy of Lupus Nephritis. Completed NCT00204022 Phase 3 Mycophenolate mofetil;Azathioprine
7 Induction Treatment of Proliferative Lupus Nephritis With Leflunomide Combined With Prednisone Completed NCT00268567 Phase 2, Phase 3 leflunomide combined with prednisone
8 Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis Terminated NCT00430677 Phase 2, Phase 3 Corticosteroids (prednisone or prednisolone);Abatacept;Abatacept;Mycophenolate mofetil (MMF);Abatacept
9 The Efficacy of Enteric-coated Mycophenolate Sodium (EC-MPS) (Myfortic) in The Treatment of Relapse or Resistant Proliferative Lupus Nephritis Terminated NCT01015456 Phase 3 mycophenolate sodium;cyclophosphamide
10 Paricalcitol for the Treatment of Immunoglobulin A Nephropathy Withdrawn NCT00599963 Phase 3 paricalcitol
11 Steroids in the Maintenance of Remission of Proliferative Lupus Nephritis Withdrawn NCT00539799 Phase 3 prednisolone;Placebo
12 BG9588 (Anti-CD40L Antibody) to Treat Lupus Nephritis Completed NCT00001789 Phase 2 BG9588
13 Daratumumab in Treatment of PGNMID and C3 GN Recruiting NCT03095118 Phase 2 Daratumumab
14 ACE-inhibitors in Extracapillary Glomerulonephritis Recruiting NCT02682459 Phase 2 Lisinopril
15 Safety and Efficacy of Two Doses of Anifrolumab Compared to Placebo in Adult Subjects With Active Proliferative Lupus Nephritis Recruiting NCT02547922 Phase 2 Placebo
16 Cyclophosphamide and Fludarabine to Treat Lupus Nephritis Completed NCT00001676 Phase 1 SQ Fludarabine
17 Tacrolimus Versus Cyclophosphamide as Treatment for Lupus Nephritis Completed NCT01207297 Phase 1 Tacrolimus;cyclophosphamide
18 An Multi-site Prospective Study to Assess the Efficacy and Safety of MMF in the Treatment of Proliferative IgA Nephropathy(IgAN) Completed NCT01269021 mycophenolate mofetil plus lower dose of Prednisone;Prednisone in full dose
19 Leflunomide Versus Azathioprine for Maintenance Therapy of Lupus Nephritis Recruiting NCT01172002 Leflunomide;Azathioprine
20 Tonsillectomy and Primitive IgA Nephropathy in Children: Strasbourg Cohort and Assessment Practices in Inter North East Region Recruiting NCT02829164
21 Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein Nephritis Recruiting NCT02811770

Search NIH Clinical Center for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

Anatomical Context for Proliferative Glomerulonephritis

MalaCards organs/tissues related to Proliferative Glomerulonephritis:

39
Kidney, Bone, T Cells, Endothelial, B Cells, Neutrophil, Monocytes

Publications for Proliferative Glomerulonephritis

Articles related to Proliferative Glomerulonephritis:

(show top 50) (show all 397)
id Title Authors Year
1
Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene. ( 28566604 )
2017
2
Mesangial proliferative glomerulonephritis: A glomerular disease or a non-specific morphological change? ( 28621006 )
2017
3
Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case report. ( 28385149 )
2017
4
Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. ( 28810602 )
2017
5
Post-infectious Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits Associated with Complement Factor H Mutation. ( 28381748 )
2017
6
Monoclonal immunoglobulin-associated proliferative glomerulonephritis characterized by organized deposits of striated ultra-substructures: A case report. ( 28628381 )
2017
7
Proliferative glomerulonephritis with monotypic IgA-kappa deposits in a 10-year-old. ( 28807265 )
2017
8
Proliferative glomerulonephritis with monoclonal IgG deposits in two kidney allografts successfully treated with rituximab. ( 28616219 )
2017
9
C3 mesangial proliferative glomerulonephritis initially presenting with atypical hemolytic uremic syndrome: a case report. ( 27460033 )
2016
10
Th1, Th2 and Treg/T17 cytokines in two types of proliferative glomerulonephritis. ( 27194829 )
2016
11
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits complicated by immunoglobulin A nephropathy in the renal allograft. ( 26971743 )
2016
12
De Novo Proliferative Glomerulonephritis with Monoclonal IgG Deposits of the IgG1I_ Subtype in a Kidney Allograft. ( 26976360 )
2016
13
AJKD Atlas of Renal Pathology: Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits. ( 26916379 )
2016
14
Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice. ( 27815652 )
2016
15
Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft. ( 26997395 )
2016
16
Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence? ( 26937085 )
2016
17
Immune Complex-Mediated Proliferative Glomerulonephritis Induced by Paclitaxel Treatment. ( 27845869 )
2016
18
Proliferative Glomerulonephritis With Monoclonal IgG1I_ Deposits in a Hepatitis C Virus-Positive Patient. ( 26612277 )
2016
19
Hepatitis C virus-related mixed cryoglobulinemic endocapillary proliferative glomerulonephritis and B-cell non-Hodgkin lymphoma: a case report and literature review. ( 26367728 )
2015
20
Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts. ( 26613031 )
2015
21
Post-Legionellosis Proliferative Glomerulonephritis. ( 26648502 )
2015
22
A case of endocapillary proliferative glomerulonephritis with macrophages phagocytosing monoclonal immunoglobulin lambda light chain. ( 25410550 )
2015
23
Glomerular Damage in Experimental Proliferative Glomerulonephritis Under Glomerular Capillary Hypertension. ( 25871528 )
2015
24
Proliferative glomerulonephritis with monoclonal immunoglobulin deposition disease: The utility of routine staining with immunoglobulin light chains. ( 26664209 )
2015
25
Significance of CD163-Positive Macrophages in Proliferative Glomerulonephritis. ( 26379042 )
2015
26
Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report. ( 25932265 )
2015
27
Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls. ( 26443483 )
2015
28
Correlation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression. ( 25715120 )
2015
29
Hydrogen peroxide-inducible clone-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice. ( 25835392 )
2015
30
Diffuse mesangial and endocapillary cell proliferative glomerulonephritis with persistent hypocomplementemia in a child. ( 26629229 )
2015
31
Proliferative glomerulonephritis with monoclonal immunoglobulin A light-chain deposits in the renal allograft. ( 24842824 )
2014
32
Proliferative Glomerulonephritis Due to Monoclonal Deposition With Organized Substructures. ( 25308093 )
2014
33
Immune profile of IgA-dominant diffuse proliferative glomerulonephritis. ( 25878780 )
2014
34
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. ( 24701045 )
2014
35
Recurrent Proliferative Glomerulonephritis With Monoclonal IgG Deposits After a Renal Transplant Which Was Insensitive to Pulse Therapy Remitted by Double Filtration Plasmapheresis. ( 25275829 )
2014
36
Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature. ( 25484532 )
2014
37
Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis. ( 24858931 )
2014
38
Diffuse segmental and pure diffuse global proliferative glomerulonephritis: different patterns of class IV lupus nephritis. ( 25017669 )
2014
39
Nephrotic syndrome secondary to proliferative glomerulonephritis with monoclonal immunoglobulin deposits of lambda light chain. ( 25136462 )
2014
40
Transition from endocapillary proliferative glomerulonephritis to membranoproliferative glomerulonephritis in a patient with a prolonged human parvovirus B19 infection. ( 23442257 )
2013
41
Proliferative glomerulonephritis with discrete deposition of monoclonal immunoglobulin I^1 CH 2 heavy chain and I_ light chain: a new variant of monoclonal immunoglobulin deposition disease. ( 23356227 )
2013
42
Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia. ( 23725649 )
2013
43
Monoclonal gammopathy-associated pauci-immune extracapillary-proliferative glomerulonephritis successfully treated with bortezomib. ( 24282629 )
2013
44
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. ( 22641568 )
2013
45
Monoclonal gammopathy-associated proliferative glomerulonephritis. ( 24182705 )
2013
46
Relapsing proliferative glomerulonephritis with monoclonal IgG deposits showing circumferential crescentic glomerulonephritis. ( 26069833 )
2013
47
A rare case of juvenile acute non-proliferative glomerulonephritis with a 6-year follow-up experience. ( 22297470 )
2013
48
Close relations between podocyte injuries and membranous proliferative glomerulonephritis in autoimmune murine models. ( 23817053 )
2013
49
Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology. ( 22641580 )
2013
50
Recurrent proliferative glomerulonephritis with monoclonal IgG deposits of IgG2I> subtype in a transplanted kidney: a case report. ( 23474011 )
2013

Variations for Proliferative Glomerulonephritis

Expression for Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for Proliferative Glomerulonephritis

Pathways related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 C3 CCL2 CD79A CFH CR1 IFNG
2
Show member pathways
12.72 C3 CCL2 IFNG IL6
3
Show member pathways
12.7 C3 IFNG IL4 IL6
4
Show member pathways
12.57 C3 CCL2 IFNG IL4 IL6
5 12.38 CCL2 CD79A IFNG IL4
6
Show member pathways
12.14 CCL2 IFNG IL4 IL6
7
Show member pathways
12.06 IFNG IL4 IL6
8
Show member pathways
12.04 IFNG IL4 IL6
9
Show member pathways
12.01 C3 CR1 IFNG IL4
10
Show member pathways
12 IFNG IL4 IL6
11
Show member pathways
11.97 C3 CFH CR1
12 11.96 C3 CR1 IFNG IL6
13 11.95 C3 CFH CR1
14
Show member pathways
11.93 C3 CFH CR1
15 11.84 CCL2 IL4 IL6
16
Show member pathways
11.8 C3 CFH CR1
17
Show member pathways
11.76 IFNG IL4 IL6
18 11.75 CR1 IL4 IL6
19 11.7 CCL2 IFNG IL6
20 11.65 IFNG IL4 IL6
21 11.64 CCL2 IFNG IL4 IL6
22 11.63 CXCR3 IFNG IL4
23 11.55 CR1 IL4 IL6
24 11.52 CD79A IFNG IL4 IL6
25 11.41 C3 CR1 IL6
26 11.32 CCL2 IL4 IL6
27 11.07 CCL2 IL4 IL6
28 11.07 IFNG IL4
29 11.06 CCL2 CTGF IL4 IL6
30 11.05 IFNG IL4 IL6
31 11.04 CCL2 IFNG
32 10.97 IFNG IL4 IL6
33 10.78 IL4 IL6
34 10.61 CCL2 CR1 IFNG IL6

GO Terms for Proliferative Glomerulonephritis

Cellular components related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 C3 CCL2 CFH CTGF IFNG IL4
2 extracellular region GO:0005576 9.56 C3 CCL2 CFH CTGF IFNG IL4
3 external side of plasma membrane GO:0009897 9.02 CD79A CXCR3 IFNG IL4 IL6

Biological processes related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 CTGF IFNG IL4 IL6
2 response to drug GO:0042493 9.87 CCL2 IFNG IL4 IL6
3 cell surface receptor signaling pathway GO:0007166 9.83 CCL2 CD79A CXCR3 IFNG
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.81 CCL2 CTGF IL6
5 aging GO:0007568 9.8 CCL2 CTGF IL6
6 immune response GO:0006955 9.8 C3 CCL2 IFNG IL4 IL6
7 chemotaxis GO:0006935 9.79 CCL2 CXCR3 IL4
8 response to organic cyclic compound GO:0014070 9.78 CTGF IL4 IL6
9 cellular response to lipopolysaccharide GO:0071222 9.77 CCL2 IFNG IL6
10 regulation of complement activation GO:0030449 9.77 C3 CFH CR1
11 response to wounding GO:0009611 9.69 CCL2 CTGF IL6
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IFNG IL4 IL6
13 positive regulation of T cell proliferation GO:0042102 9.63 IFNG IL4 IL6
14 positive regulation of collagen biosynthetic process GO:0032967 9.62 CCL2 CTGF
15 humoral immune response GO:0006959 9.61 CCL2 IFNG IL6
16 complement activation, alternative pathway GO:0006957 9.58 C3 CFH
17 positive regulation of protein import into nucleus, translocation GO:0033160 9.58 IFNG IL6
18 positive regulation of isotype switching to IgG isotypes GO:0048304 9.56 IFNG IL4
19 positive regulation of protein phosphorylation GO:0001934 9.56 C3 CTGF IFNG IL4
20 positive regulation of chemokine biosynthetic process GO:0045080 9.55 IFNG IL4
21 inflammatory response GO:0006954 9.55 C3 CCL2 CXCR3 IL6 SIGLEC1
22 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IFNG IL4
23 positive regulation of apoptotic cell clearance GO:2000427 9.49 C3 CCL2
24 regulation of vascular endothelial growth factor production GO:0010574 9.37 CCL2 IL6
25 neutrophil apoptotic process GO:0001781 9.32 IFNG IL6
26 response to amino acid GO:0043200 9.13 CCL2 CTGF IL6
27 defense response to protozoan GO:0042832 8.8 IFNG IL4 IL6

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 CTGF IL4 IL6
2 heparin binding GO:0008201 9.13 CCL2 CFH CTGF
3 cytokine activity GO:0005125 8.92 CCL2 IFNG IL4 IL6

Sources for Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....