MCID: PRL003
MIFTS: 45

Proliferative Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Proliferative Glomerulonephritis

MalaCards integrated aliases for Proliferative Glomerulonephritis:

Name: Proliferative Glomerulonephritis 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4778
NCIt 46 C35281
SNOMED-CT 64 441815006
UMLS 69 C0235618

Summaries for Proliferative Glomerulonephritis

MalaCards based summary : Proliferative Glomerulonephritis is related to acute proliferative glomerulonephritis and mesangial proliferative glomerulonephritis. An important gene associated with Proliferative Glomerulonephritis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Mycophenolic acid and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and endothelial, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Proliferative Glomerulonephritis

Diseases in the Proliferative Glomerulonephritis family:

Acute Proliferative Glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 acute proliferative glomerulonephritis 34.2 CCL2 CD79A
2 mesangial proliferative glomerulonephritis 33.9 CCL2 CD79A IL6
3 glomerulonephritis 30.7 C3 CCL2 CD79A CFH CR1
4 membranoproliferative glomerulonephritis 29.8 C3 CD79A CFH
5 anemia, autoimmune hemolytic 29.7 C3 CD79A
6 temporal arteritis 29.7 CCL2 IFNG IL6
7 brucellosis 29.6 IFNG IL4 IL6
8 leprosy 3 29.6 CD79A IFNG IL4
9 rheumatoid arthritis 28.7 CCL2 CD79A IFNG IL4 IL6
10 psoriasis 28.6 CCL2 CXCR3 IFNG IL4 IL6
11 malaria 28.1 CCL2 CR1 CXCR3 IFNG IL4 IL6
12 systemic lupus erythematosus 27.9 C3 CCL2 CD79A CR1 CXCR3 IFNG
13 c1q deficiency 11.1
14 dense deposit disease 10.4 C3 CFH
15 retinal drusen 10.4 C3 CFH
16 t-cell/histiocyte rich large b cell lymphoma 10.4 CR1 IFNG
17 neuroschistosomiasis 10.4 CD79A IFNG
18 sporotrichosis 10.3 CD79A IFNG
19 enterocolitis 10.3 C3 CFH
20 immune suppression 10.3 IFNG IL6
21 complement factor i deficiency 10.3 C3 CR1
22 posterior uveitis 10.3 CFH IFNG
23 denture stomatitis 10.3 CCL2 IL6
24 orthostatic proteinuria 10.3 C3 CD79A
25 strongyloidiasis 10.3 CD79A IFNG
26 chronic graft versus host disease 10.3 CD79A IFNG
27 ascaris lumbricoides infection 10.3 IFNG IL6
28 mycoplasmal pneumonia 10.3 IFNG IL4
29 acute maxillary sinusitis 10.3 C3 CD79A
30 clonorchiasis 10.3 CD79A IFNG
31 arteriolosclerosis 10.3 C3 CD79A
32 hyperlucent lung 10.3 IFNG IL4
33 meconium aspiration syndrome 10.3 IFNG IL6
34 nonspecific interstitial pneumonia 10.3 CCL2 CXCR3 IFNG
35 relapsing polychondritis 10.3 IFNG IL6
36 central nervous system vasculitis 10.3 IFNG IL6
37 baylisascariasis 10.3 IFNG IL4
38 penicillin allergy 10.3 IFNG IL4
39 pulmonary sarcoidosis 10.3 CCL2 CXCR3 IFNG
40 atopic keratoconjunctivitis 10.3 IFNG IL4
41 stachybotrys chartarum 10.3 CCL2 IL6
42 sarcoidosis 1 10.2 CCL2 CXCR3 IFNG
43 hypersensitivity vasculitis 10.2 C3 CD79A
44 chronic eosinophilic pneumonia 10.2 CXCR3 IL6
45 scleritis 10.2 CCL2 IL4
46 central nervous system disease 10.2 CCL2 CXCR3 IFNG
47 multicentric castleman disease 10.2 IFNG IL6
48 hyper ige syndrome 10.2 IFNG IL4
49 nephrotic syndrome 10.2
50 anterior uveitis 10.2 CFH IL6

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to Proliferative Glomerulonephritis

Symptoms & Phenotypes for Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 CFH IL6 SIGLEC1 CTGF CXCR3 C3
2 hematopoietic system MP:0005397 10.01 CFH IL6 SIGLEC1 CXCR3 C3 IFNG
3 immune system MP:0005387 9.97 CFH IL6 SIGLEC1 CXCR3 C3 IFNG
4 liver/biliary system MP:0005370 9.73 IL6 CTGF C3 IFNG IL4 CD79A
5 normal MP:0002873 9.7 CFH CTGF CXCR3 C3 IFNG IL4
6 renal/urinary system MP:0005367 9.5 CXCR3 C3 IFNG IL4 CD79A CFH
7 vision/eye MP:0005391 9.1 CFH IL6 CTGF C3 IFNG IL4

Drugs & Therapeutics for Proliferative Glomerulonephritis

Drugs for Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 2, Phase 3 24280-93-1 446541
2
Mycophenolate mofetil Approved, Investigational Phase 2, Phase 3 128794-94-5 5281078
3
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
4
Abatacept Approved Phase 2, Phase 3 332348-12-6 10237
5
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
6
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
7 Prednisolone acetate Phase 2, Phase 3
8 glucocorticoids Phase 2, Phase 3
9 Methylprednisolone acetate Phase 2, Phase 3
10 Methylprednisolone Hemisuccinate Phase 2, Phase 3
11 Hormone Antagonists Phase 2, Phase 3
12 Hormones Phase 2, Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
14 Anti-Bacterial Agents Phase 2, Phase 3
15 Pharmaceutical Solutions Phase 2, Phase 3
16 Anti-Infective Agents Phase 2, Phase 3
17 Prednisolone hemisuccinate Phase 2, Phase 3
18 Immunosuppressive Agents Phase 2, Phase 3
19 Prednisolone phosphate Phase 2, Phase 3
20 Anti-Inflammatory Agents Phase 2, Phase 3
21 Antibiotics, Antitubercular Phase 2, Phase 3
22 Antineoplastic Agents, Hormonal Phase 2, Phase 3
23 Antirheumatic Agents Phase 2, Phase 3
24 Antitubercular Agents Phase 2, Phase 3
25
Daratumumab Approved Phase 2 945721-28-8
26 Antibodies, Monoclonal Phase 2
27 Immunoglobulins Phase 2
28 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis Terminated NCT00430677 Phase 2, Phase 3 Corticosteroids (prednisone or prednisolone);Abatacept;Abatacept;Mycophenolate mofetil (MMF);Abatacept
2 Daratumumab in Treatment of PGNMID and C3 GN Recruiting NCT03095118 Phase 2 Daratumumab

Search NIH Clinical Center for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

Anatomical Context for Proliferative Glomerulonephritis

MalaCards organs/tissues related to Proliferative Glomerulonephritis:

38
Kidney, T Cells, Endothelial, B Cells, Neutrophil, Monocytes, Lung

Publications for Proliferative Glomerulonephritis

Articles related to Proliferative Glomerulonephritis:

(show top 50) (show all 403)
# Title Authors Year
1
A case report of proliferative glomerulonephritis with monoclonal immunoglobulin M-kappa deposits without associated lymphoproliferative disorder or detectable paraproteinemia. ( 29230710 )
2017
2
Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. ( 28810602 )
2017
3
Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene. ( 28566604 )
2017
4
Proliferative glomerulonephritis with monoclonal IgG deposits; an unusual cause of de novo disease in kidney allograft. ( 28975104 )
2017
5
Urinalysis in the Evaluation of Proliferative Glomerulonephritis. ( 28973230 )
2017
6
Proliferative glomerulonephritis with monoclonal IgG deposits in two kidney allografts successfully treated with rituximab. ( 28616219 )
2017
7
Post-infectious Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits Associated with Complement Factor H Mutation. ( 28381748 )
2017
8
Mesangial proliferative glomerulonephritis: A glomerular disease or a non-specific morphological change? ( 28621006 )
2017
9
Monoclonal immunoglobulin-associated proliferative glomerulonephritis characterized by organized deposits of striated ultra-substructures: A case report. ( 28628381 )
2017
10
Proliferative Glomerulonephritis With Masked Monoclonal Deposits Responsive to Myeloma Therapy. ( 29270532 )
2017
11
Proliferative glomerulonephritis with monotypic IgA-kappa deposits in a 10-year-old. ( 28807265 )
2017
12
Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis. ( 29348949 )
2017
13
Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case report. ( 28385149 )
2017
14
A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features. ( 29209544 )
2017
15
De Novo Proliferative Glomerulonephritis with Monoclonal IgG Deposits of the IgG1I_ Subtype in a Kidney Allograft. ( 26976360 )
2016
16
Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft. ( 26997395 )
2016
17
Proliferative Glomerulonephritis With Monoclonal IgG1I_ Deposits in a Hepatitis C Virus-Positive Patient. ( 26612277 )
2016
18
Th1, Th2 and Treg/T17 cytokines in two types of proliferative glomerulonephritis. ( 27194829 )
2016
19
Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice. ( 27815652 )
2016
20
AJKD Atlas of Renal Pathology: Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits. ( 26916379 )
2016
21
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits complicated by immunoglobulin A nephropathy in the renal allograft. ( 26971743 )
2016
22
C3 mesangial proliferative glomerulonephritis initially presenting with atypical hemolytic uremic syndrome: a case report. ( 27460033 )
2016
23
Immune Complex-Mediated Proliferative Glomerulonephritis Induced by Paclitaxel Treatment. ( 27845869 )
2016
24
Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence? ( 26937085 )
2016
25
Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls. ( 26443483 )
2015
26
A case of endocapillary proliferative glomerulonephritis with macrophages phagocytosing monoclonal immunoglobulin lambda light chain. ( 25410550 )
2015
27
Correlation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression. ( 25715120 )
2015
28
Diffuse mesangial and endocapillary cell proliferative glomerulonephritis with persistent hypocomplementemia in a child. ( 26629229 )
2015
29
Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report. ( 25932265 )
2015
30
Hydrogen peroxide-inducible clone-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice. ( 25835392 )
2015
31
Hepatitis C virus-related mixed cryoglobulinemic endocapillary proliferative glomerulonephritis and B-cell non-Hodgkin lymphoma: a case report and literature review. ( 26367728 )
2015
32
Proliferative glomerulonephritis with monoclonal immunoglobulin deposition disease: The utility of routine staining with immunoglobulin light chains. ( 26664209 )
2015
33
Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts. ( 26613031 )
2015
34
Post-Legionellosis Proliferative Glomerulonephritis. ( 26648502 )
2015
35
Significance of CD163-Positive Macrophages in Proliferative Glomerulonephritis. ( 26379042 )
2015
36
Glomerular Damage in Experimental Proliferative Glomerulonephritis Under Glomerular Capillary Hypertension. ( 25871528 )
2015
37
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. ( 24701045 )
2014
38
Proliferative glomerulonephritis with monoclonal immunoglobulin A light-chain deposits in the renal allograft. ( 24842824 )
2014
39
Recurrent Proliferative Glomerulonephritis With Monoclonal IgG Deposits After a Renal Transplant Which Was Insensitive to Pulse Therapy Remitted by Double Filtration Plasmapheresis. ( 25275829 )
2014
40
Immune profile of IgA-dominant diffuse proliferative glomerulonephritis. ( 25878780 )
2014
41
Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis. ( 24858931 )
2014
42
Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature. ( 25484532 )
2014
43
Diffuse segmental and pure diffuse global proliferative glomerulonephritis: different patterns of class IV lupus nephritis. ( 25017669 )
2014
44
Proliferative Glomerulonephritis Due to Monoclonal Deposition With Organized Substructures. ( 25308093 )
2014
45
Nephrotic syndrome secondary to proliferative glomerulonephritis with monoclonal immunoglobulin deposits of lambda light chain. ( 25136462 )
2014
46
Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology. ( 22641580 )
2013
47
Efficacy of antisense monocyte chemoattractant protein-1 (MCP-1) in a rat model of mesangial proliferative glomerulonephritis. ( 23991758 )
2013
48
Recurrent proliferative glomerulonephritis with monoclonal IgG deposits of IgG2I> subtype in a transplanted kidney: a case report. ( 23474011 )
2013
49
Goodpasture's syndrome with concomitant immune complex mixed membranous and proliferative glomerulonephritis. ( 23320965 )
2013
50
Monoclonal gammopathy-associated proliferative glomerulonephritis. ( 24182705 )
2013

Variations for Proliferative Glomerulonephritis

Expression for Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for Proliferative Glomerulonephritis

Pathways related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 C3 CCL2 CD79A CFH CR1 IFNG
2
Show member pathways
12.7 C3 IFNG IL4 IL6
3
Show member pathways
12.57 C3 CCL2 IFNG IL4 IL6
4 12.41 CCL2 CD79A IFNG IL4
5
Show member pathways
12.37 C3 CCL2 IFNG IL6
6
Show member pathways
12.22 IFNG IL4 IL6
7
Show member pathways
12.16 CCL2 IFNG IL4 IL6
8
Show member pathways
12.14 CCL2 IFNG IL4 IL6
9
Show member pathways
12.04 IFNG IL4 IL6
10
Show member pathways
12.01 IFNG IL4 IL6
11
Show member pathways
12.01 C3 CR1 IFNG IL4
12
Show member pathways
11.98 C3 CFH CR1
13 11.96 C3 CFH CR1
14 11.96 C3 CR1 IFNG IL6
15
Show member pathways
11.94 C3 CFH CR1
16 11.86 CCL2 IL4 IL6
17
Show member pathways
11.81 C3 CFH CR1
18 11.77 CR1 IL4 IL6
19
Show member pathways
11.73 IFNG IL4 IL6
20 11.71 CCL2 IFNG IL6
21 11.66 IFNG IL4 IL6
22 11.64 CXCR3 IFNG IL4
23 11.64 CCL2 IFNG IL4 IL6
24 11.53 CR1 IL4 IL6
25 11.52 CD79A IFNG IL4 IL6
26 11.41 C3 CR1 IL6
27 11.32 CCL2 IL4 IL6
28 11.07 CCL2 IL4 IL6
29 11.07 IFNG IL4
30 11.06 CCL2 CTGF IL4 IL6
31 11.05 CCL2 IFNG
32 11.05 IFNG IL4 IL6
33 10.97 IFNG IL4 IL6
34 10.87 CCL2 CTGF IL4 IL6
35 10.7 IL4 IL6
36 10.61 CCL2 CR1 IFNG IL6

GO Terms for Proliferative Glomerulonephritis

Cellular components related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 C3 CCL2 CFH CTGF IFNG IL4
2 extracellular region GO:0005576 9.23 C3 CCL2 CFH CTGF IFNG IL4

Biological processes related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.67 C3 CTGF IFNG
2 cell surface receptor signaling pathway GO:0007166 9.67 CCL2 CD79A CXCR3 IFNG
3 chemotaxis GO:0006935 9.65 CCL2 CXCR3 IL4
4 regulation of complement activation GO:0030449 9.61 C3 CFH CR1
5 immune response GO:0006955 9.55 C3 CCL2 IFNG IL4 IL6
6 B cell activation GO:0042113 9.51 CD79A IL4
7 regulation of regulatory T cell differentiation GO:0045589 9.46 CR1 IFNG
8 humoral immune response GO:0006959 9.43 CCL2 IFNG IL6
9 complement activation, alternative pathway GO:0006957 9.4 C3 CFH
10 regulation of receptor activity GO:0010469 9.35 CCL2 CTGF IFNG IL4 IL6
11 positive regulation of apoptotic cell clearance GO:2000427 9.32 C3 CCL2
12 inflammatory response GO:0006954 9.02 C3 CCL2 CXCR3 IL6 SIGLEC1

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 CTGF IL4 IL6
2 cytokine activity GO:0005125 8.92 CCL2 IFNG IL4 IL6

Sources for Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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