MCID: PRL003
MIFTS: 39

Proliferative Glomerulonephritis malady

Summaries for Proliferative Glomerulonephritis

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MalaCards based summary: Proliferative Glomerulonephritis is related to glomerulonephritis and nephritis. An important gene associated with Proliferative Glomerulonephritis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Immune response IL 23 signaling pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds ramipril and olmesartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and endothelial, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Aliases & Classifications for Proliferative Glomerulonephritis

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt
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Proliferative Glomerulonephritis, Aliases & Descriptions:

Name: Proliferative Glomerulonephritis 9 43 60


External Ids:

Disease Ontology9 DOID:4778
SNOMED-CT55 441815006
NCIt38 C35281

Related Diseases for Proliferative Glomerulonephritis

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Diseases in the Proliferative Glomerulonephritis family:

Acute Proliferative Glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.1CCL2, CD79A, AGTR1
2nephritis30.9CD79A, CXCR3, CCL2
3acute poststreptococcal glomerulonephritis30.8CD79A
4systemic lupus erythematosus30.7CCL2, CXCR3, CD79A
5vasculitis30.6CD79A, CCL2
6proteinuria30.5CCL2, AGTR1, CD79A
7lupus nephritis30.5CCL2, CXCR3, CD79A
8connective tissue disease30.4CCL2, CD79A
9renal fibrosis30.4CCL2, AGTR1
10kidney disease30.2AGTR1, CCL2
11arthritis30.1AGTR1, CXCR3, CCL2, CCR1
12rheumatoid arthritis30.0CCL2, CD79A, CCR1, CXCR3
13mesangial proliferative glomerulonephritis11.2
14nephrotic syndrome10.6
15acute proliferative glomerulonephritis10.6
16lupus erythematosus10.5
17hepatitis10.5
18hepatitis c virus10.3
19multiple myeloma10.3
20hepatitis c10.3
21cryoglobulinemia10.3
22immune-complex glomerulonephritis10.3
23myeloma10.3
24endotheliitis10.3
25pneumonia10.3CCL2, CD79A
26lipoid nephrosis10.3CD79A, CCL2
27membranous glomerulonephritis, antenatal10.2CD79A, CCL2
28interstitial lung disease10.2CD79A, CCL2
29leprosy10.2
30arteriovenous fistula10.2
31antiphospholipid syndrome10.2
32membranoproliferative glomerulonephritis10.2
33endocarditis10.2
34interstitial nephritis10.2
35retinitis10.2
36castleman's disease10.2
37polymyositis10.2
38focal segmental glomerulosclerosis10.2CD79A, AGTR1
39periapical granuloma10.2CXCR3, CCL2
40extrinsic allergic alveolitis10.2CXCR3, CCL2
41pulmonary sarcoidosis10.1CCL2, CXCR3
42central nervous system disease10.1CCL2, CXCR3
43atopy10.1CD79A, CXCR3
44sjogren's syndrome10.1CD79A, CXCR3
45uveitis10.1CXCR3, CCL2
46dermatitis10.1CD79A, CXCR3
47pulmonary fibrosis, idiopathic10.1CXCR3, CCL2
48allergic asthma10.1CCL2, CCR1
49hypersensitivity reaction type ii disease10.1CXCR3, CCL2
50c1q deficiency10.1

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to proliferative glomerulonephritis

Symptoms for Proliferative Glomerulonephritis

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Drugs & Therapeutics for Proliferative Glomerulonephritis

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Drug clinical trials:

Search ClinicalTrials for Proliferative Glomerulonephritis

Search NIH Clinical Center for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

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Anatomical Context for Proliferative Glomerulonephritis

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MalaCards organs/tissues related to Proliferative Glomerulonephritis:

31
Kidney, T cells, Endothelial, Bone marrow, Bone, Spleen, Brain, Lung, Prostate, Monocytes, B cells, Neutrophil

Animal Models for Proliferative Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5CD79A, CCR1, CCL2, CXCR3
2MP:00053678.5CXCR3, CCR1, CD79A, AGTR1
3MP:00053858.1AGTR1, CXCR3, CCL2, CCR1
4MP:00053877.9CCR1, CCL2, CD79A, AGTR1, CXCR3
5MP:00053767.8CXCR3, CCR1, CD79A, AGTR1, CCL2

Publications for Proliferative Glomerulonephritis

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Articles related to Proliferative Glomerulonephritis:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature. (25484532)
2014
2
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. (24701045)
2014
3
Diffuse segmental and pure diffuse global proliferative glomerulonephritis: different patterns of class IV lupus nephritis. (25017669)
2014
4
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
5
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. (24649023)
2013
6
Antiribosomal-P protein antibodies are associated with proliferative glomerulonephritis more strongly than with membranous glomerulonephritis in Japanese patients with systemic lupus erythematosus. (22042098)
2012
7
A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. (23326256)
2012
8
Autosomal dominant polycystic kidney disease with diffuse proliferative glomerulonephritis - an unusual association: a case report and review of the literature. (20429898)
2010
9
Bilateral macular sub-retinal fluid and retinal pigment epithelial detachment associated with type 2 membrano-proliferative glomerulonephritis. (18430038)
2008
10
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. (16334979)
2005
11
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
12
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
13
Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. (12105242)
2002
14
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. (11979343)
2002
15
Expression of complement regulatory proteins in diffuse proliferative glomerulonephritis. (10787010)
2000
16
Growth factor pathways in proliferative glomerulonephritis. (10847321)
2000
17
In situ hybridization in the study of remodeling in proliferative glomerulonephritis. (9502386)
1998
18
Urinary erythrophagocytes in proliferative glomerulonephritis. (9750096)
1998
19
Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. (9239405)
1997
20
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis. (7758332)
1995
21
Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis. (7783409)
1995
22
Alteration of C3 nephritic factor in a patient with membrano-proliferative glomerulonephritis type II. (7891786)
1995
23
Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. (8402004)
1993
24
Platelet-derived growth factor and proliferative glomerulonephritis. (8468932)
1993
25
IgA nephropathy in two HLA-identical brothers and acute, diffuse proliferative glomerulonephritis in the third, HLA-different brother. (1501751)
1992
26
Proliferative glomerulonephritis in mice induced by sea snake (Aipysurus laevis) venom. (1446167)
1992
27
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
28
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
29
Proliferative glomerulonephritis and the activity of lymphocyte DNA transcriptional enzymes. (1821613)
1991
30
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
31
Auricular chondritis and diffuse proliferative glomerulonephritis in primary SjAPgren's syndrome. (2782978)
1989
32
Mixed membranous and proliferative glomerulonephritis in primary SjAPgren's syndrome. (2590814)
1989
33
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
34
Therapeutic effect of cyclosporin A and steroid on serum sickness type nephritis in the rat. 2. Suppressive effect on full-blown proliferative glomerulonephritis. (3063863)
1988
35
Mesangio-proliferative glomerulonephritis associated with Kimura's disease. (3180515)
1988
36
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
37
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. (3549083)
1987
38
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis (PGN) associated with identical HL-A antigens. (3313816)
1986
39
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis, without mesangial IgA deposits (PGN), associated with identical HL-A antigens. (6518679)
1984
40
Activation of platelets in patients with chronic proliferative glomerulonephritis and the nephrotic syndrome. (6459902)
1982
41
Proliferative glomerulonephritis in experimental Leishmania donovani infection of the golden hamster. (7333089)
1981
42
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
43
Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits. (158675)
1979
44
Unusual ultrastructural features in a case of acute diffuse proliferative glomerulonephritis. (527963)
1979
45
Proliferative glomerulonephritis in monoclonal gammopathy. (917180)
1977
46
Serial biopsies in diffuse proliferative glomerulonephritis in adults: an attempt for a better understanding of sporadic acute glomerulonephritis. (4620922)
1973
47
Complement studies in membrano-proliferative glomerulonephritis. (4625395)
1972
48
The relationship of neutrophilic and eosinophilic leukocytes to the glomerular capillary basement membrane in acute proliferative glomerulonephritis. (5136992)
1971
49
Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy. (4186205)
1969
50
Ultrastructural demonstration of injury and perforation of glomerular capillary basement membrane in acute proliferative glomerulonephritis. (4184004)
1969

Variations for Proliferative Glomerulonephritis

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Expression for genes affiliated with Proliferative Glomerulonephritis

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Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for genes affiliated with Proliferative Glomerulonephritis

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Pathways related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.5AGTR1, CCL2
2
Show member pathways
8.9CCR1, CCL2, CXCR3
3
Show member pathways
8.9CCR1, CCL2, CXCR3
4
Show member pathways
8.9CCR1, CCL2, CXCR3
5
Show member pathways
8.9CXCR3, CCL2, CCR1
6
Show member pathways
8.9CXCR3, CCL2, CCR1
7
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
8
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
9
Show member pathways
8.1PTPRQ, CXCR3, CCL2, CCR1

Compounds for genes affiliated with Proliferative Glomerulonephritis

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Compounds related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1ramipril43 1210.9AGTR1, CD79A
2olmesartan43 28 1211.9AGTR1, CCL2
3sulfasalazine28 43 49 1212.9CD79A, CCL2
4shikonin439.9CCR1, CCL2
5gw966243 2810.9AGTR1, CCL2
6mdms439.9CCR1, CCL2
7valsartan43 59 28 1212.9AGTR1, CCL2
8telmisartan43 28 1211.9AGTR1, CCL2
9irbesartan43 28 49 1212.9CCL2, AGTR1
10candesartan43 49 28 1212.8CCL2, AGTR1
11captopril43 59 49 28 1213.8AGTR1, CD79A
12mcp 1439.8CCL2, CXCR3
138-isoprostane439.8AGTR1, CCL2
14larc439.8CCL2, CXCR3
15methacholine43 49 1211.8CD79A, AGTR1
16ang ii439.8CCL2, AGTR1
17ccl5289.8CXCR3, CCR1
18ccl13289.8CCR1, CXCR3
19ccl7289.8CXCR3, CCR1
20vitamin b12439.7CD79A, CCL2
21groalpha439.7CXCR3, CCL2
22il 10439.7CCL2, CXCR3
23fluvastatin43 49 28 1212.6CCL2, AGTR1
24tarc439.6CXCR3, CCL2
25allergens439.5CXCR3, CD79A
26leukotriene b443 59 2411.5CCR1, CCL2
27losartan43 49 28 1212.5CCL2, AGTR1
28n acetylcysteine439.5CCL2, CD79A, AGTR1
29vitamin d439.4AGTR1, CD79A, CCL2
30fibrinogen439.4CCL2, AGTR1, CD79A
31norepinephrine43 24 1211.4CD79A, CCL2, AGTR1
32tacrolimus43 49 1211.3AGTR1, CD79A, CXCR3
33ccl343 2810.3CXCR3, CCL2, CCR1
34histamine43 28 2411.3CD79A, CCL2, CXCR3
35ccl443 2810.3CXCR3, CCR1, CCL2
36actinomycin d439.3AGTR1, CCR1, CCL2
37rantes439.3CXCR3, CCL2, CCR1
38pravastatin43 49 28 24 1213.2CCL2, AGTR1
39cycloheximide439.2AGTR1, CCL2, CCR1
40pge2438.9CCL2, CCR1, CD79A, CXCR3
41creatinine438.9CXCR3, CCL2, CD79A, AGTR1
42vegf438.9CD79A, CXCR3, AGTR1, CCL2
43arginine438.9CCL2, CD79A, CXCR3, AGTR1
44heparin43 28 24 1211.8AGTR1, CD79A, CCR1, CXCR3
45superoxide43 249.8AGTR1, CCR1, CXCR3, CCL2
46cholesterol43 28 24 1211.8CCL2, AGTR1, CXCR3
47phosphatidylinositol438.8CCL2, AGTR1, CCR1, CXCR3
48nitric oxide43 24 1210.8CCL2, CCR1, AGTR1, CXCR3
49serine438.6CCR1, CXCR3, CCL2, AGTR1
50dexamethasone43 49 28 1211.4AGTR1, CD79A, CXCR3, CCL2, CCR1

GO Terms for genes affiliated with Proliferative Glomerulonephritis

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Cellular components related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CD79A, CCR1, CXCR3

Biological processes related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:00700989.7CCR1, CCL2
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.6CCR1, CCL2
3cellular calcium ion homeostasisGO:00068749.5CCR1, CCL2
4calcium-mediated signalingGO:00197229.3AGTR1, CXCR3
5negative regulation of angiogenesisGO:00165259.1CCL2, CXCR3
6chemotaxisGO:00069359.1CCR1, CCL2, CXCR3
7cell surface receptor signaling pathwayGO:00071669.1CXCR3, CCL2, CCR1
8positive regulation of cytosolic calcium ion concentrationGO:00072049.0AGTR1, CCR1, CXCR3
9inflammatory responseGO:00069549.0CCR1, CCL2, CXCR3
10G-protein coupled receptor signaling pathwayGO:00071869.0CXCR3, CCL2, AGTR1
11cell adhesionGO:00071558.8CXCR3, CCL2, CCR1

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.3CCR1, CXCR3

Products for genes affiliated with Proliferative Glomerulonephritis

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Sources for Proliferative Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet