MCID: PRL003
MIFTS: 46

Proliferative Glomerulonephritis malady

Nephrological diseases category
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Summaries for Proliferative Glomerulonephritis

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MalaCards based summary: Proliferative Glomerulonephritis is related to glomerulonephritis and nephritis. An important gene associated with Proliferative Glomerulonephritis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Immune response IL 23 signaling pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds ramipril and olmesartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and endothelial, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Proliferative Glomerulonephritis

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT
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Proliferative Glomerulonephritis, Aliases & Descriptions:

Name: Proliferative Glomerulonephritis 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:4778
SNOMED-CT57 441815006
NCIt39 C35281

Related Diseases for Proliferative Glomerulonephritis

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Diseases in the Acute Proliferative Glomerulonephritis family:

proliferative glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.1CCL2, CD79A, AGTR1
2nephritis30.9CD79A, CXCR3, CCL2
3systemic lupus erythematosus30.7CCL2, CXCR3, CD79A
4vasculitis30.6CD79A, CCL2
5proteinuria30.5CCL2, AGTR1, CD79A
6hypertension30.5CCL2, CD79A, AGTR1
7membranous glomerulonephritis30.5CD79A, CCL2
8lupus nephritis30.5CCL2, CXCR3, CD79A
9connective tissue disease30.4CCL2, CD79A
10renal fibrosis30.4CCL2, AGTR1
11chronic obstructive pulmonary disease30.1CCL2, CXCR3
12arthritis30.1AGTR1, CXCR3, CCL2, CCR1
13rheumatoid arthritis30.0CCL2, CD79A, CCR1, CXCR3
14mesangial proliferative glomerulonephritis11.1
15nephrotic syndrome10.6
16acute proliferative glomerulonephritis10.6
17lupus erythematosus10.5
18hepatitis10.5
19acute poststreptococcal glomerulonephritis10.5CD79A
20multiple myeloma10.3
21cryoglobulinemia10.3
22hepatitis c10.3
23immune-complex glomerulonephritis10.3
24myeloma10.3
25hepatitis c virus10.3
26endotheliitis10.3
27pneumonia10.3CCL2, CD79A
28lipoid nephrosis10.3CD79A, CCL2
29interstitial lung disease10.3CD79A, CCL2
30focal segmental glomerulosclerosis10.2CD79A, AGTR1
31arteriovenous fistula10.2
32familial mediterranean fever10.2
33antiphospholipid syndrome10.2
34membranoproliferative glomerulonephritis10.2
35endocarditis10.2
36interstitial nephritis10.2
37leprosy10.2
38retinitis10.2
39castleman's disease10.2
40polymyositis10.2
41periapical granuloma10.2CXCR3, CCL2
42extrinsic allergic alveolitis10.2CXCR3, CCL2
43pulmonary sarcoidosis10.2CCL2, CXCR3
44central nervous system disease10.1CCL2, CXCR3
45atopy10.1CD79A, CXCR3
46sjogren's syndrome10.1CD79A, CXCR3
47uveitis10.1CXCR3, CCL2
48dermatitis10.1CD79A, CXCR3
49idiopathic pulmonary fibrosis10.1CXCR3, CCL2
50allergic asthma10.1CCL2, CCR1

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to proliferative glomerulonephritis

Symptoms for Proliferative Glomerulonephritis

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Drugs & Therapeutics for Proliferative Glomerulonephritis

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Drug clinical trials:

Search ClinicalTrials for Proliferative Glomerulonephritis

Search NIH Clinical Center for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

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Anatomical Context for Proliferative Glomerulonephritis

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MalaCards organs/tissues related to Proliferative Glomerulonephritis:

32
Kidney, T cells, Endothelial, Bone marrow, Bone, Brain, Lung, Monocytes, B cells, Neutrophil

Animal Models for Proliferative Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5AGTR1, CD79A, CCR1, CXCR3
2MP:00053978.5CD79A, CCR1, CCL2, CXCR3
3MP:00053858.1CXCR3, CCL2, CCR1, AGTR1
4MP:00053877.9CXCR3, CCL2, CCR1, CD79A, AGTR1
5MP:00053767.8CXCR3, CCL2, CCR1, CD79A, AGTR1

Publications for Proliferative Glomerulonephritis

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Articles related to Proliferative Glomerulonephritis:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. (24701045)
2014
2
Diffuse segmental and pure diffuse global proliferative glomerulonephritis: different patterns of class IV lupus nephritis. (25017669)
2014
3
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
4
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. (24649023)
2013
5
Antiribosomal-P protein antibodies are associated with proliferative glomerulonephritis more strongly than with membranous glomerulonephritis in Japanese patients with systemic lupus erythematosus. (22042098)
2012
6
A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. (23326256)
2012
7
Autosomal dominant polycystic kidney disease with diffuse proliferative glomerulonephritis - an unusual association: a case report and review of the literature. (20429898)
2010
8
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. (19617668)
2009
9
Bilateral macular sub-retinal fluid and retinal pigment epithelial detachment associated with type 2 membrano-proliferative glomerulonephritis. (18430038)
2008
10
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. (16334979)
2005
11
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
12
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
13
Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. (12105242)
2002
14
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. (11979343)
2002
15
Expression of complement regulatory proteins in diffuse proliferative glomerulonephritis. (10787010)
2000
16
Growth factor pathways in proliferative glomerulonephritis. (10847321)
2000
17
In situ hybridization in the study of remodeling in proliferative glomerulonephritis. (9502386)
1998
18
Urinary erythrophagocytes in proliferative glomerulonephritis. (9750096)
1998
19
Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. (9239405)
1997
20
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis. (7758332)
1995
21
Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis. (7783409)
1995
22
Alteration of C3 nephritic factor in a patient with membrano-proliferative glomerulonephritis type II. (7891786)
1995
23
Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. (8402004)
1993
24
Platelet-derived growth factor and proliferative glomerulonephritis. (8468932)
1993
25
IgA nephropathy in two HLA-identical brothers and acute, diffuse proliferative glomerulonephritis in the third, HLA-different brother. (1501751)
1992
26
Proliferative glomerulonephritis in mice induced by sea snake (Aipysurus laevis) venom. (1446167)
1992
27
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
28
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
29
Proliferative glomerulonephritis and the activity of lymphocyte DNA transcriptional enzymes. (1821613)
1991
30
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
31
Auricular chondritis and diffuse proliferative glomerulonephritis in primary SjAPgren's syndrome. (2782978)
1989
32
Mixed membranous and proliferative glomerulonephritis in primary SjAPgren's syndrome. (2590814)
1989
33
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
34
Therapeutic effect of cyclosporin A and steroid on serum sickness type nephritis in the rat. 2. Suppressive effect on full-blown proliferative glomerulonephritis. (3063863)
1988
35
Mesangio-proliferative glomerulonephritis associated with Kimura's disease. (3180515)
1988
36
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
37
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. (3549083)
1987
38
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis (PGN) associated with identical HL-A antigens. (3313816)
1986
39
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis, without mesangial IgA deposits (PGN), associated with identical HL-A antigens. (6518679)
1984
40
Activation of platelets in patients with chronic proliferative glomerulonephritis and the nephrotic syndrome. (6459902)
1982
41
Proliferative glomerulonephritis in experimental Leishmania donovani infection of the golden hamster. (7333089)
1981
42
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
43
Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits. (158675)
1979
44
Unusual ultrastructural features in a case of acute diffuse proliferative glomerulonephritis. (527963)
1979
45
Proliferative glomerulonephritis in monoclonal gammopathy. (917180)
1977
46
Serial biopsies in diffuse proliferative glomerulonephritis in adults: an attempt for a better understanding of sporadic acute glomerulonephritis. (4620922)
1973
47
Complement studies in membrano-proliferative glomerulonephritis. (4625395)
1972
48
The relationship of neutrophilic and eosinophilic leukocytes to the glomerular capillary basement membrane in acute proliferative glomerulonephritis. (5136992)
1971
49
Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy. (4186205)
1969
50
Ultrastructural demonstration of injury and perforation of glomerular capillary basement membrane in acute proliferative glomerulonephritis. (4184004)
1969

Variations for Proliferative Glomerulonephritis

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Expression for genes affiliated with Proliferative Glomerulonephritis

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Expression patterns in normal tissues for genes affiliated with Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for genes affiliated with Proliferative Glomerulonephritis

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Pathways related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.5AGTR1, CCL2
2
Show member pathways
8.9CCR1, CCL2, CXCR3
3
Show member pathways
8.9CCR1, CCL2, CXCR3
4
Show member pathways
8.9CCR1, CCL2, CXCR3
5
Show member pathways
8.9CXCR3, CCL2, CCR1
6
Show member pathways
8.9CXCR3, CCL2, CCR1
7
Show member pathways
Peptide GPCRs37
8.8AGTR1, CCR1, CXCR3
8
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
9
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
10
Show member pathways
8.1PTPRQ, CXCR3, CCL2, CCR1

Compounds for genes affiliated with Proliferative Glomerulonephritis

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Compounds related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1ramipril44 1110.9CD79A, AGTR1
2olmesartan44 28 1111.9CCL2, AGTR1
3sulfasalazine28 44 50 1112.9CD79A, CCL2
4shikonin449.9CCR1, CCL2
5gw966244 2810.9CCL2, AGTR1
6mdms449.9CCL2, CCR1
7valsartan44 61 28 1112.9AGTR1, CCL2
8telmisartan44 28 1111.9CCL2, AGTR1
9irbesartan44 28 50 1112.9AGTR1, CCL2
10candesartan44 50 28 1112.8CCL2, AGTR1
11captopril44 61 50 28 1113.8AGTR1, CD79A
12mcp 1449.8CCL2, CXCR3
138-isoprostane449.8CCL2, AGTR1
14larc449.8CXCR3, CCL2
15methacholine44 50 1111.8CD79A, AGTR1
16ccl13289.8CXCR3, CCR1
17ccl7289.8CXCR3, CCR1
18ccl5289.8CXCR3, CCR1
19ang ii449.8AGTR1, CCL2
20vitamin b12449.7CD79A, CCL2
21groalpha449.7CCL2, CXCR3
22il 10449.7CCL2, CXCR3
23fluvastatin44 50 28 1112.6AGTR1, CCL2
24tarc449.6CCL2, CXCR3
25allergens449.5CD79A, CXCR3
26leukotriene b444 61 2411.5CCR1, CCL2
27losartan44 50 28 1112.5CCL2, AGTR1
28n acetylcysteine449.5AGTR1, CD79A, CCL2
29vitamin d449.4AGTR1, CD79A, CCL2
30fibrinogen449.4CCL2, CD79A, AGTR1
31norepinephrine44 24 1111.4AGTR1, CD79A, CCL2
32tacrolimus44 50 1111.3AGTR1, CD79A, CXCR3
33ccl344 2810.3CCR1, CCL2, CXCR3
34histamine44 28 2411.3CD79A, CCL2, CXCR3
35ccl444 2810.3CXCR3, CCL2, CCR1
36actinomycin d449.3AGTR1, CCR1, CCL2
37rantes449.3CCR1, CCL2, CXCR3
38pravastatin44 50 28 24 1113.2AGTR1, CCL2
39cycloheximide449.2CCL2, CCR1, AGTR1
40pge2448.9CD79A, CCR1, CCL2, CXCR3
41creatinine448.9CXCR3, CCL2, CD79A, AGTR1
42vegf448.9AGTR1, CD79A, CCL2, CXCR3
43arginine448.9CXCR3, CCL2, CD79A, AGTR1
44heparin44 28 24 1111.8AGTR1, CD79A, CCR1, CXCR3
45superoxide44 249.8CXCR3, CCL2, CCR1, AGTR1
46cholesterol44 28 24 1111.8AGTR1, CCL2, CXCR3
47phosphatidylinositol448.8CXCR3, CCL2, CCR1, AGTR1
48nitric oxide44 24 1110.8CXCR3, CCL2, CCR1, AGTR1
49serine448.6AGTR1, CCR1, CCL2, CXCR3
50dexamethasone44 50 28 1111.4AGTR1, CD79A, CCR1, CCL2, CXCR3

GO Terms for genes affiliated with Proliferative Glomerulonephritis

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Cellular components related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CD79A, CCR1, CXCR3

Biological processes related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:0700989.7CCR1, CCL2
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.6CCR1, CCL2
3cellular calcium ion homeostasisGO:0068749.5CCR1, CCL2
4calcium-mediated signalingGO:0197229.3AGTR1, CXCR3
5negative regulation of angiogenesisGO:0165259.1CCL2, CXCR3
6chemotaxisGO:0069359.1CCR1, CCL2, CXCR3
7cell surface receptor signaling pathwayGO:0071669.1CXCR3, CCL2, CCR1
8positive regulation of cytosolic calcium ion concentrationGO:0072049.0AGTR1, CCR1, CXCR3
9inflammatory responseGO:0069549.0CCR1, CCL2, CXCR3
10G-protein coupled receptor signaling pathwayGO:0071869.0CXCR3, CCL2, AGTR1
11cell adhesionGO:0071558.8CXCR3, CCL2, CCR1

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.3CCR1, CXCR3

Products for genes affiliated with Proliferative Glomerulonephritis

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Sources for Proliferative Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet