MCID: PRL003
MIFTS: 46

Proliferative Glomerulonephritis malady

Nephrological diseases category
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Summaries for Proliferative Glomerulonephritis

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33MalaCards
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MalaCards: Proliferative Glomerulonephritis is related to glomerulonephritis and nephritis. An important gene associated with Proliferative Glomerulonephritis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Immune response IL 23 signaling pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds ramipril and olmesartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Proliferative Glomerulonephritis

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

proliferative glomerulonephritis 8 45 62


External Ids:

Disease Ontology8 DOID:4778
SNOMED-CT58 441815006
NCIt40 C35281

Related Diseases for Proliferative Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Acute Proliferative Glomerulonephritis family:

proliferative glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.0AGTR1, CD79A, CCL2
2nephritis30.8CD79A, CCL2, CXCR3
3systemic lupus erythematosus30.7CXCR3, CCL2, CD79A
4proteinuria30.4CCL2, CD79A, AGTR1
5hypertension30.4AGTR1, CD79A, CCL2
6vasculitis30.4CD79A, CCL2
7arthritis30.3AGTR1, CCR1, CCL2, CXCR3
8lupus nephritis30.3CD79A, CCL2, CXCR3
9acute poststreptococcal glomerulonephritis30.2CD79A
10rheumatoid arthritis30.2CD79A, CCR1, CCL2, CXCR3
11membranous glomerulonephritis30.2CD79A, CCL2
12connective tissue disease30.2CCL2, CD79A
13renal fibrosis30.1AGTR1, CCL2
14mesangial proliferative glomerulonephritis11.1
15nephrotic syndrome10.6
16acute proliferative glomerulonephritis10.6
17lupus erythematosus10.5
18hepatitis10.5
19hepatitis c10.3
20cryoglobulinemia10.3
21immune-complex glomerulonephritis10.3
22multiple myeloma10.3
23myeloma10.3
24hepatitis c virus10.3
25endotheliitis10.3
26arteriovenous fistula10.2
27familial mediterranean fever10.2
28antiphospholipid syndrome10.2
29membranoproliferative glomerulonephritis10.2
30endocarditis10.2
31leprosy10.2
32retinitis10.2
33castleman's disease10.2
34polymyositis10.2
35pneumonia10.1CCL2, CD79A
36lipoid nephrosis10.1CCL2, CD79A
37interstitial lung disease10.1CCL2, CD79A
38crohn's disease10.1
39pharyngitis10.1
40lepromatous leprosy10.1
41autoimmune hemolytic anemia10.1
42aphthous stomatitis10.1
43polymyalgia rheumatica10.1
44polycystic kidney disease10.1
45legionnaires' disease10.1
46hemolytic-uremic syndrome10.1
47hepatitis a10.1
48q fever10.1
49mixed connective tissue disease10.1
50macroglobulinemia10.1

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to proliferative glomerulonephritis

Symptoms for Proliferative Glomerulonephritis

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Drugs & Therapeutics for Proliferative Glomerulonephritis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Proliferative Glomerulonephritis

Search NIH Clinical Center for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

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Anatomical Context for Proliferative Glomerulonephritis

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33MalaCards
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MalaCards organs/tissues related to Proliferative Glomerulonephritis:

33
Kidney, Endothelial, T cells, B cells, Monocytes, Prostate, Lung, Brain, Bone, Bone marrow

Animal Models for Proliferative Glomerulonephritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5AGTR1, CD79A, CCR1, CXCR3
2MP:00053978.5CD79A, CCR1, CCL2, CXCR3
3MP:00053858.1CXCR3, CCL2, CCR1, AGTR1
4MP:00053877.9CXCR3, CCL2, CCR1, CD79A, AGTR1
5MP:00053767.8CXCR3, CCL2, CCR1, CD79A, AGTR1

Publications for Proliferative Glomerulonephritis

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52PubMed
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Articles related to Proliferative Glomerulonephritis:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
2
Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia. (23725649)
2013
3
Antiribosomal-P protein antibodies are associated with proliferative glomerulonephritis more strongly than with membranous glomerulonephritis in Japanese patients with systemic lupus erythematosus. (22042098)
2012
4
A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. (23326256)
2012
5
Autosomal dominant polycystic kidney disease with diffuse proliferative glomerulonephritis - an unusual association: a case report and review of the literature. (20429898)
2010
6
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. (19617668)
2009
7
Bilateral macular sub-retinal fluid and retinal pigment epithelial detachment associated with type 2 membrano-proliferative glomerulonephritis. (18430038)
2008
8
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. (16334979)
2005
9
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
10
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
11
Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. (12105242)
2002
12
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. (11979343)
2002
13
Expression of complement regulatory proteins in diffuse proliferative glomerulonephritis. (10787010)
2000
14
Growth factor pathways in proliferative glomerulonephritis. (10847321)
2000
15
In situ hybridization in the study of remodeling in proliferative glomerulonephritis. (9502386)
1998
16
Urinary erythrophagocytes in proliferative glomerulonephritis. (9750096)
1998
17
Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. (9239405)
1997
18
Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis. (8651905)
1996
19
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis. (7758332)
1995
20
Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis. (7783409)
1995
21
Alteration of C3 nephritic factor in a patient with membrano-proliferative glomerulonephritis type II. (7891786)
1995
22
Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. (8402004)
1993
23
Platelet-derived growth factor and proliferative glomerulonephritis. (8468932)
1993
24
IgA nephropathy in two HLA-identical brothers and acute, diffuse proliferative glomerulonephritis in the third, HLA-different brother. (1501751)
1992
25
Proliferative glomerulonephritis in mice induced by sea snake (Aipysurus laevis) venom. (1446167)
1992
26
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
27
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
28
Proliferative glomerulonephritis and the activity of lymphocyte DNA transcriptional enzymes. (1821613)
1991
29
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
30
Auricular chondritis and diffuse proliferative glomerulonephritis in primary SjAPgren's syndrome. (2782978)
1989
31
Mixed membranous and proliferative glomerulonephritis in primary SjAPgren's syndrome. (2590814)
1989
32
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
33
Therapeutic effect of cyclosporin A and steroid on serum sickness type nephritis in the rat. 2. Suppressive effect on full-blown proliferative glomerulonephritis. (3063863)
1988
34
Mesangio-proliferative glomerulonephritis associated with Kimura's disease. (3180515)
1988
35
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
36
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. (3549083)
1987
37
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis (PGN) associated with identical HL-A antigens. (3313816)
1986
38
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis, without mesangial IgA deposits (PGN), associated with identical HL-A antigens. (6518679)
1984
39
Clinical features and glomerular immunofluorescence of renal biopsies from children with nephrotic syndrome due to minimal change disease and two variants of mesangial proliferative glomerulonephritis. (6370883)
1984
40
Activation of platelets in patients with chronic proliferative glomerulonephritis and the nephrotic syndrome. (6459902)
1982
41
Proliferative glomerulonephritis in experimental Leishmania donovani infection of the golden hamster. (7333089)
1981
42
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
43
Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits. (158675)
1979
44
Unusual ultrastructural features in a case of acute diffuse proliferative glomerulonephritis. (527963)
1979
45
Proliferative glomerulonephritis in monoclonal gammopathy. (917180)
1977
46
Serial biopsies in diffuse proliferative glomerulonephritis in adults: an attempt for a better understanding of sporadic acute glomerulonephritis. (4620922)
1973
47
Complement studies in membrano-proliferative glomerulonephritis. (4625395)
1972
48
The relationship of neutrophilic and eosinophilic leukocytes to the glomerular capillary basement membrane in acute proliferative glomerulonephritis. (5136992)
1971
49
Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy. (4186205)
1969
50
Ultrastructural demonstration of injury and perforation of glomerular capillary basement membrane in acute proliferative glomerulonephritis. (4184004)
1969

Variations for Proliferative Glomerulonephritis

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Expression for genes affiliated with Proliferative Glomerulonephritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for genes affiliated with Proliferative Glomerulonephritis

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 53QIAGEN, 54R&D Systems, 55Reactome, 30KEGG, 12EMD Millipore
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Pathways related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.5AGTR1, CCL2
2
Show member pathways
8.9CCR1, CCL2, CXCR3
3
Show member pathways
8.9CCR1, CCL2, CXCR3
4
Show member pathways
8.9CCR1, CCL2, CXCR3
5
Show member pathways
8.9CXCR3, CCL2, CCR1
6
Show member pathways
8.9CXCR3, CCL2, CCR1
7
Show member pathways
Peptide GPCRs38
8.8AGTR1, CCR1, CXCR3
8
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
9
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
10
Show member pathways
8.1PTPRQ, CXCR3, CCL2, CCR1

Compounds for genes affiliated with Proliferative Glomerulonephritis

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1ramipril45 1110.9CD79A, AGTR1
2olmesartan45 29 1111.9CCL2, AGTR1
3sulfasalazine29 45 51 1112.9CD79A, CCL2
4shikonin459.9CCR1, CCL2
5gw966245 2910.9CCL2, AGTR1
6mdms459.9CCL2, CCR1
7valsartan45 61 29 1112.9AGTR1, CCL2
8telmisartan45 29 1111.9CCL2, AGTR1
9irbesartan45 29 51 1112.9AGTR1, CCL2
10candesartan45 51 29 1112.8CCL2, AGTR1
11captopril45 61 51 29 1113.8AGTR1, CD79A
12mcp 1459.8CCL2, CXCR3
138-isoprostane459.8CCL2, AGTR1
14larc459.8CXCR3, CCL2
15methacholine45 51 1111.8CD79A, AGTR1
16ccl13299.8CXCR3, CCR1
17ccl7299.8CXCR3, CCR1
18ccl5299.8CXCR3, CCR1
19ang ii459.8AGTR1, CCL2
20vitamin b12459.7CD79A, CCL2
21groalpha459.7CCL2, CXCR3
22il 10459.7CCL2, CXCR3
23fluvastatin45 51 29 1112.6AGTR1, CCL2
24tarc459.6CCL2, CXCR3
25allergens459.5CD79A, CXCR3
26leukotriene b445 61 2411.5CCR1, CCL2
27losartan45 51 29 1112.5CCL2, AGTR1
28n acetylcysteine459.5AGTR1, CD79A, CCL2
29vitamin d459.4AGTR1, CD79A, CCL2
30fibrinogen459.4CCL2, CD79A, AGTR1
31norepinephrine45 24 1111.4AGTR1, CD79A, CCL2
32tacrolimus45 51 1111.3AGTR1, CD79A, CXCR3
33ccl345 2910.3CCR1, CCL2, CXCR3
34histamine45 29 2411.3CD79A, CCL2, CXCR3
35ccl445 2910.3CXCR3, CCL2, CCR1
36actinomycin d459.3AGTR1, CCR1, CCL2
37rantes459.3CCR1, CCL2, CXCR3
38pravastatin45 51 29 24 1113.2AGTR1, CCL2
39cycloheximide459.2CCL2, CCR1, AGTR1
40pge2458.9CD79A, CCR1, CCL2, CXCR3
41creatinine458.9CXCR3, CCL2, CD79A, AGTR1
42vegf458.9AGTR1, CD79A, CCL2, CXCR3
43arginine458.9CXCR3, CCL2, CD79A, AGTR1
44heparin45 29 24 1111.8AGTR1, CD79A, CCR1, CXCR3
45superoxide45 249.8CXCR3, CCL2, CCR1, AGTR1
46cholesterol45 29 24 1111.8AGTR1, CCL2, CXCR3
47phosphatidylinositol458.8CXCR3, CCL2, CCR1, AGTR1
48nitric oxide45 24 1110.8CXCR3, CCL2, CCR1, AGTR1
49serine458.6AGTR1, CCR1, CCL2, CXCR3
50dexamethasone45 51 29 1111.4AGTR1, CD79A, CCR1, CCL2, CXCR3

GO Terms for genes affiliated with Proliferative Glomerulonephritis

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16Gene Ontology
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Cellular components related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CD79A, CCR1, CXCR3

Biological processes related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:0700989.7CCR1, CCL2
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.6CCR1, CCL2
3cellular calcium ion homeostasisGO:0068749.5CCR1, CCL2
4calcium-mediated signalingGO:0197229.3AGTR1, CXCR3
5negative regulation of angiogenesisGO:0165259.1CCL2, CXCR3
6chemotaxisGO:0069359.1CCR1, CCL2, CXCR3
7cell surface receptor signaling pathwayGO:0071669.1CXCR3, CCL2, CCR1
8positive regulation of cytosolic calcium ion concentrationGO:0072049.0AGTR1, CCR1, CXCR3
9inflammatory responseGO:0069549.0CCR1, CCL2, CXCR3
10G-protein coupled receptor signaling pathwayGO:0071869.0CXCR3, CCL2, AGTR1
11cell adhesionGO:0071558.8CXCR3, CCL2, CCR1

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.3CCR1, CXCR3

Products for genes affiliated with Proliferative Glomerulonephritis

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Sources for Proliferative Glomerulonephritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet