MCID: PRL003
MIFTS: 46

Proliferative Glomerulonephritis malady

Nephrological diseases category

Summaries for Proliferative Glomerulonephritis

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34MalaCards
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MalaCards: Proliferative Glomerulonephritis is related to glomerulonephritis and nephritis. An important gene associated with Proliferative Glomerulonephritis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Immune response IL 23 signaling pathway and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds ramipril and olmesartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Proliferative Glomerulonephritis

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

proliferative glomerulonephritis 9 46 63


External Ids:

Disease Ontology9 DOID:4778
SNOMED-CT59 441815006
NCIt41 C35281

Related Diseases for Proliferative Glomerulonephritis

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18GeneCards, 19GeneDecks
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Diseases in the Acute Proliferative Glomerulonephritis family:

proliferative glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis32.0AGTR1, CD79A, CCL2
2nephritis30.8CD79A, CCL2, CXCR3
3systemic lupus erythematosus30.7CXCR3, CCL2, CD79A
4proteinuria30.4CCL2, CD79A, AGTR1
5hypertension30.4AGTR1, CD79A, CCL2
6vasculitis30.4CD79A, CCL2
7arthritis30.3AGTR1, CCR1, CCL2, CXCR3
8lupus nephritis30.3CD79A, CCL2, CXCR3
9acute poststreptococcal glomerulonephritis30.2CD79A
10rheumatoid arthritis30.2CD79A, CCR1, CCL2, CXCR3
11membranous glomerulonephritis30.2CD79A, CCL2
12connective tissue disease30.2CCL2, CD79A
13renal fibrosis30.1AGTR1, CCL2
14mesangial proliferative glomerulonephritis11.1
15nephrotic syndrome10.6
16acute proliferative glomerulonephritis10.6
17lupus erythematosus10.5
18hepatitis10.5
19hepatitis c10.3
20cryoglobulinemia10.3
21immune-complex glomerulonephritis10.3
22multiple myeloma10.3
23myeloma10.3
24hepatitis c virus10.3
25endotheliitis10.3
26arteriovenous fistula10.2
27familial mediterranean fever10.2
28antiphospholipid syndrome10.2
29membranoproliferative glomerulonephritis10.2
30endocarditis10.2
31leprosy10.2
32retinitis10.2
33castleman's disease10.2
34polymyositis10.2
35pneumonia10.1CCL2, CD79A
36lipoid nephrosis10.1CCL2, CD79A
37interstitial lung disease10.1CCL2, CD79A
38crohn's disease10.1
39pharyngitis10.1
40lepromatous leprosy10.1
41autoimmune hemolytic anemia10.1
42aphthous stomatitis10.1
43polymyalgia rheumatica10.1
44polycystic kidney disease10.1
45legionnaires' disease10.1
46hemolytic-uremic syndrome10.1
47hepatitis a10.1
48q fever10.1
49mixed connective tissue disease10.1
50macroglobulinemia10.1

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to proliferative glomerulonephritis

Symptoms for Proliferative Glomerulonephritis

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Drugs & Therapeutics for Proliferative Glomerulonephritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Proliferative Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Proliferative Glomerulonephritis

Search NIH Clinical Center for Proliferative Glomerulonephritis

Search CenterWatch for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

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Anatomical Context for Proliferative Glomerulonephritis

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34MalaCards
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MalaCards organs/tissues related to Proliferative Glomerulonephritis:

34
Kidney, Endothelial, T cells, B cells, Monocytes, Prostate, Lung, Brain, Bone, Bone marrow

Animal Models for Proliferative Glomerulonephritis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5AGTR1, CD79A, CCR1, CXCR3
2MP:00053978.5CD79A, CCR1, CCL2, CXCR3
3MP:00053858.1CXCR3, CCL2, CCR1, AGTR1
4MP:00053877.9CXCR3, CCL2, CCR1, CD79A, AGTR1
5MP:00053767.8CXCR3, CCL2, CCR1, CD79A, AGTR1

Publications for Proliferative Glomerulonephritis

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Sources:
53PubMed
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Articles related to Proliferative Glomerulonephritis:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
2
Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia. (23725649)
2013
3
Antiribosomal-P protein antibodies are associated with proliferative glomerulonephritis more strongly than with membranous glomerulonephritis in Japanese patients with systemic lupus erythematosus. (22042098)
2012
4
A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. (23326256)
2012
5
Autosomal dominant polycystic kidney disease with diffuse proliferative glomerulonephritis - an unusual association: a case report and review of the literature. (20429898)
2010
6
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. (19617668)
2009
7
Bilateral macular sub-retinal fluid and retinal pigment epithelial detachment associated with type 2 membrano-proliferative glomerulonephritis. (18430038)
2008
8
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. (16334979)
2005
9
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
10
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. (17642763)
2004
11
Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. (12105242)
2002
12
Glucocorticoid diminishes vascular endothelial growth factor and exacerbates proteinuria in rats with mesangial proliferative glomerulonephritis. (11979343)
2002
13
Expression of complement regulatory proteins in diffuse proliferative glomerulonephritis. (10787010)
2000
14
Growth factor pathways in proliferative glomerulonephritis. (10847321)
2000
15
In situ hybridization in the study of remodeling in proliferative glomerulonephritis. (9502386)
1998
16
Urinary erythrophagocytes in proliferative glomerulonephritis. (9750096)
1998
17
Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. (9239405)
1997
18
Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis. (8651905)
1996
19
Endothelin 1 and cyclic guanosine monophosphate in nonimmunological progression of mesangial proliferative glomerulonephritis. (7758332)
1995
20
Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis. (7783409)
1995
21
Alteration of C3 nephritic factor in a patient with membrano-proliferative glomerulonephritis type II. (7891786)
1995
22
Idiopathic polymyositis complicated by arthritis and mesangial proliferative glomerulonephritis: case report and review of the literature. (8402004)
1993
23
Platelet-derived growth factor and proliferative glomerulonephritis. (8468932)
1993
24
IgA nephropathy in two HLA-identical brothers and acute, diffuse proliferative glomerulonephritis in the third, HLA-different brother. (1501751)
1992
25
Proliferative glomerulonephritis in mice induced by sea snake (Aipysurus laevis) venom. (1446167)
1992
26
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
27
A case of IgM-associated mesangial proliferative glomerulonephritis with a giant paramesangial spherical deposit. (1798222)
1991
28
Proliferative glomerulonephritis and the activity of lymphocyte DNA transcriptional enzymes. (1821613)
1991
29
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
30
Auricular chondritis and diffuse proliferative glomerulonephritis in primary SjAPgren's syndrome. (2782978)
1989
31
Mixed membranous and proliferative glomerulonephritis in primary SjAPgren's syndrome. (2590814)
1989
32
Renal granuloma and mesangial proliferative glomerulonephritis in leprosy. (3221115)
1988
33
Therapeutic effect of cyclosporin A and steroid on serum sickness type nephritis in the rat. 2. Suppressive effect on full-blown proliferative glomerulonephritis. (3063863)
1988
34
Mesangio-proliferative glomerulonephritis associated with Kimura's disease. (3180515)
1988
35
Mesangial proliferative glomerulonephritis. Natural history and effects of dextran sulfate. (2437347)
1987
36
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. (3549083)
1987
37
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis (PGN) associated with identical HL-A antigens. (3313816)
1986
38
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis, without mesangial IgA deposits (PGN), associated with identical HL-A antigens. (6518679)
1984
39
Clinical features and glomerular immunofluorescence of renal biopsies from children with nephrotic syndrome due to minimal change disease and two variants of mesangial proliferative glomerulonephritis. (6370883)
1984
40
Activation of platelets in patients with chronic proliferative glomerulonephritis and the nephrotic syndrome. (6459902)
1982
41
Proliferative glomerulonephritis in experimental Leishmania donovani infection of the golden hamster. (7333089)
1981
42
Mesangial proliferative glomerulonephritis in mixed connective tissue disease (MCTD). (7363519)
1980
43
Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits. (158675)
1979
44
Unusual ultrastructural features in a case of acute diffuse proliferative glomerulonephritis. (527963)
1979
45
Proliferative glomerulonephritis in monoclonal gammopathy. (917180)
1977
46
Serial biopsies in diffuse proliferative glomerulonephritis in adults: an attempt for a better understanding of sporadic acute glomerulonephritis. (4620922)
1973
47
Complement studies in membrano-proliferative glomerulonephritis. (4625395)
1972
48
The relationship of neutrophilic and eosinophilic leukocytes to the glomerular capillary basement membrane in acute proliferative glomerulonephritis. (5136992)
1971
49
Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy. (4186205)
1969
50
Ultrastructural demonstration of injury and perforation of glomerular capillary basement membrane in acute proliferative glomerulonephritis. (4184004)
1969

Variations for Proliferative Glomerulonephritis

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Expression for genes affiliated with Proliferative Glomerulonephritis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for genes affiliated with Proliferative Glomerulonephritis

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51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems, 56Reactome, 31KEGG, 13EMD Millipore
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Pathways related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.5AGTR1, CCL2
2
Show member pathways
8.9CCR1, CCL2, CXCR3
3
Show member pathways
8.9CCR1, CCL2, CXCR3
4
Show member pathways
8.9CCR1, CCL2, CXCR3
5
Show member pathways
8.9CXCR3, CCL2, CCR1
6
Show member pathways
8.9CXCR3, CCL2, CCR1
7
Show member pathways
Peptide GPCRs39
8.8AGTR1, CCR1, CXCR3
8
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
9
Show member pathways
8.4AGTR1, CCR1, CCL2, CXCR3
10
Show member pathways
8.1PTPRQ, CXCR3, CCL2, CCR1

Compounds for genes affiliated with Proliferative Glomerulonephritis

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1ramipril46 1210.9CD79A, AGTR1
2olmesartan46 30 1211.9CCL2, AGTR1
3sulfasalazine30 46 52 1212.9CD79A, CCL2
4shikonin469.9CCR1, CCL2
5gw966246 3010.9CCL2, AGTR1
6mdms469.9CCL2, CCR1
7valsartan46 62 30 1212.9AGTR1, CCL2
8telmisartan46 30 1211.9CCL2, AGTR1
9irbesartan46 30 52 1212.9AGTR1, CCL2
10candesartan46 52 30 1212.8CCL2, AGTR1
11captopril46 62 52 30 1213.8AGTR1, CD79A
12mcp 1469.8CCL2, CXCR3
138-isoprostane469.8CCL2, AGTR1
14larc469.8CXCR3, CCL2
15methacholine46 52 1211.8CD79A, AGTR1
16ccl13309.8CXCR3, CCR1
17ccl7309.8CXCR3, CCR1
18ccl5309.8CXCR3, CCR1
19ang ii469.8AGTR1, CCL2
20vitamin b12469.7CD79A, CCL2
21groalpha469.7CCL2, CXCR3
22il 10469.7CCL2, CXCR3
23fluvastatin46 52 30 1212.6AGTR1, CCL2
24tarc469.6CCL2, CXCR3
25allergens469.5CD79A, CXCR3
26leukotriene b446 62 2511.5CCR1, CCL2
27losartan46 52 30 1212.5CCL2, AGTR1
28n acetylcysteine469.5AGTR1, CD79A, CCL2
29vitamin d469.4AGTR1, CD79A, CCL2
30fibrinogen469.4CCL2, CD79A, AGTR1
31norepinephrine46 25 1211.4AGTR1, CD79A, CCL2
32tacrolimus46 52 1211.3AGTR1, CD79A, CXCR3
33ccl346 3010.3CCR1, CCL2, CXCR3
34histamine46 30 2511.3CD79A, CCL2, CXCR3
35ccl446 3010.3CXCR3, CCL2, CCR1
36actinomycin d469.3AGTR1, CCR1, CCL2
37rantes469.3CCR1, CCL2, CXCR3
38pravastatin46 52 30 25 1213.2AGTR1, CCL2
39cycloheximide469.2CCL2, CCR1, AGTR1
40pge2468.9CD79A, CCR1, CCL2, CXCR3
41creatinine468.9CXCR3, CCL2, CD79A, AGTR1
42vegf468.9AGTR1, CD79A, CCL2, CXCR3
43arginine468.9CXCR3, CCL2, CD79A, AGTR1
44heparin46 30 25 1211.8AGTR1, CD79A, CCR1, CXCR3
45superoxide46 259.8CXCR3, CCL2, CCR1, AGTR1
46cholesterol46 30 25 1211.8AGTR1, CCL2, CXCR3
47phosphatidylinositol468.8CXCR3, CCL2, CCR1, AGTR1
48nitric oxide46 25 1210.8CXCR3, CCL2, CCR1, AGTR1
49serine468.6AGTR1, CCR1, CCL2, CXCR3
50dexamethasone46 52 30 1211.4AGTR1, CD79A, CCR1, CCL2, CXCR3

GO Terms for genes affiliated with Proliferative Glomerulonephritis

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17Gene Ontology
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Cellular components related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CD79A, CCR1, CXCR3

Biological processes related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:0700989.7CCR1, CCL2
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.6CCR1, CCL2
3cellular calcium ion homeostasisGO:0068749.5CCR1, CCL2
4calcium-mediated signalingGO:0197229.3AGTR1, CXCR3
5negative regulation of angiogenesisGO:0165259.1CCL2, CXCR3
6chemotaxisGO:0069359.1CCR1, CCL2, CXCR3
7cell surface receptor signaling pathwayGO:0071669.1CXCR3, CCL2, CCR1
8positive regulation of cytosolic calcium ion concentrationGO:0072049.0AGTR1, CCR1, CXCR3
9inflammatory responseGO:0069549.0CCR1, CCL2, CXCR3
10G-protein coupled receptor signaling pathwayGO:0071869.0CXCR3, CCL2, AGTR1
11cell adhesionGO:0071558.8CXCR3, CCL2, CCR1

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.3CCR1, CXCR3

Products for genes affiliated with Proliferative Glomerulonephritis

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Sources for Proliferative Glomerulonephritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet