MCID: PRL003
MIFTS: 52

Proliferative Glomerulonephritis malady

Summaries for Proliferative Glomerulonephritis

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MalaCards: Proliferative Glomerulonephritis is related to glomerulonephritis and mesangial proliferative glomerulonephritis. An important gene associated with Proliferative Glomerulonephritis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are p70S6K Signaling and Glioma. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related mouse phenotypes are renal/urinary system and nervous system.

Aliases & Classifications for Proliferative Glomerulonephritis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

proliferative glomerulonephritis 8 44 60


External Ids:

Disease Ontology8 DOID:4778
SNOMED-CT56 441815006
NCIt39 C35281

Related Diseases for Proliferative Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Acute Proliferative Glomerulonephritis family:

proliferative glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.9CXCL9, CD79A, AGTR1, CCL2, CCR5
2mesangial proliferative glomerulonephritis31.6CD79A, IL6
3membranous glomerulonephritis30.9CCR5, CCL2, CD79A
4nephrotic syndrome30.8CD79A
5iga glomerulonephritis30.8CCR5, CCL2, AGTR1, CD79A, IL6
6lupus erythematosus30.7CD79A
7systemic lupus erythematosus30.7IL6, CXCR3, CD79A, CCL2, CCR5
8multiple myeloma30.4IL6
9hepatitis c30.4CXCR3, CCR5
10hypertension30.3CCL2, EDN1, AGTR1, CD79A
11proteinuria30.3CCL2, EDN1, AGTR1, VEGFA, CD79A, THY1
12myeloma30.3CCR1, VEGFA, MAPK1, CD79A, FGF2, IL6
13arthritis30.3CCR5, CCL2, CCR1, AGTR1, FGF2, CXCR3
14antiphospholipid syndrome30.2SELP, CD79A
15vasculitis30.2SELP, CD79A, CCL2
16rheumatoid arthritis30.2CCR5, CCL2, CCR1, VEGFA, MAPK1, CD79A
17purpura30.0CD79A
18prostatitis30.0CD79A
19acute poststreptococcal glomerulonephritis30.0CD79A
20myasthenia gravis30.0CCR5
21retinal detachment30.0VEGFA
22q fever30.0CD79A
23pyelonephritis30.0CD79A
24macroglobulinemia30.0CD79A
25connective tissue disease30.0IL6, CD79A, CCL2
26ischemia30.0EDN1, VEGFA, FGF2, SELP
27psoriasis30.0SELP, IL6, CXCL9, CXCR3, MAPK1, CCL2
28leukemia30.0CCR1, MAPK1, CD79A, FGF2, CXCR3, IL6
29diffuse glomerulonephritis10.8
30acute proliferative glomerulonephritis10.8
31hepatitis10.5
32immune-complex glomerulonephritis10.4
33crescentic glomerulonephritis10.3
34hepatitis a10.3
35cryoglobulinemia10.3
36arteriovenous fistula10.2
37membranoproliferative glomerulonephritis10.2
38familial mediterranean fever10.2
39exudative glomerulonephritis10.2
40endocarditis10.2
41heavy chain disease10.2
42leprosy10.2
43retinitis10.2
44hellp syndrome10.0
45crohn's disease10.0
46mixed connective tissue disease10.0
47subacute glomerulonephritis10.0
48small cell carcinoma10.0
49pharyngitis10.0
50lepromatous leprosy10.0

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to proliferative glomerulonephritis

Clinical Features for Proliferative Glomerulonephritis

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Drugs & Therapeutics for Proliferative Glomerulonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Proliferative Glomerulonephritis

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Anatomical Context for Proliferative Glomerulonephritis

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32MalaCards
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MalaCards organs/tissues related to Proliferative Glomerulonephritis:

32
Kidney, Endothelial, T cells, Monocytes, B cells, Bone, Bone marrow, Lung, Brain, Prostate

Animal Models for Proliferative Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4AGTR1, EDN1
2MP:000363110.0CCR5, EDN1, MAPK1, PTPRQ
3MP:000200610.0CCR5, CCL2, CXCR3, IL6
4MP:000536910.0FGF2, MAPK1, CCR5
5MP:00053889.5CCR1, VEGFA, MAPK1, CXCR3, IL6
6MP:00053859.5CCR5, CCL2, CCR1, EDN1, AGTR1, MAPK1
7MP:00053769.5CCR5, CCL2, CCR1, AGTR1, CD79A, CXCR3
8MP:00053709.3CCR5, CCL2, CCR1, VEGFA, MAPK1, IL6
9MP:00053819.0CCR5, CCL2, CCR1, EDN1, VEGFA, NFKBID
10MP:00053848.9CCR5, CCL2, CCR1, VEGFA, NFKBID, MAPK1
11MP:00053978.8CCR5, CCL2, CCR1, VEGFA, NFKBID, MAPK1
12MP:00107688.6CCR5, CCL2, CCR1, EDN1, AGTR1, VEGFA
13MP:00053878.5SELP, CCR5, CCL2, CCR1, AGTR1, VEGFA

Publications for Proliferative Glomerulonephritis

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50PubMed
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Articles related to Proliferative Glomerulonephritis:

(show top 50)    (show all 374)
idTitleAuthorsYear
1
Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia. (23725649)
2013
2
A rare case of juvenile acute non-proliferative glomerulonephritis with a 6-year follow-up experience. (22297470)
2013
3
Recurrent proliferative glomerulonephritis with monoclonal IgG deposits of IgG2I> subtype in a transplanted kidney: a case report. (23474011)
2013
4
Close relations between podocyte injuries and membranous proliferative glomerulonephritis in autoimmune murine models. (23817053)
2013
5
A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. (23326256)
2012
6
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. (22607047)
2012
7
Proliferative glomerulonephritis with monoclonal IgM deposits without WaldenstrAPm's macroglobulinemia: case report and review of the literature. (22377259)
2012
8
Proliferative glomerulonephritis with monoclonal IgG deposits secondary to chronic lymphocytic leukemia. Report of two cases. (21633102)
2011
9
Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. (20110667)
2010
10
Diffuse proliferative glomerulonephritis does not determine the worst outcome in childhood-onset lupus nephritis: a 23-year experience in a single centre. (19395731)
2009
11
Tranilast ameliorates experimental mesangial proliferative glomerulonephritis. (18480612)
2008
12
Chronic urticaria and mesangial proliferative glomerulonephritis: a case report. (17717029)
2007
13
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. (16092667)
2005
14
Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature. (15971069)
2005
15
A male with angioimmunoblastic T-cell lymphoma and proliferative glomerulonephritis. (15034757)
2004
16
Expression of complement regulatory proteins in diffuse proliferative glomerulonephritis. (10787010)
2000
17
Mesangial proliferative glomerulonephritis with predominant mesangial IgG deposition in renal allograft. (11096326)
2000
18
Endocapillary proliferative glomerulonephritis in a patient with parvovirus B19 infection. (11007690)
2000
19
Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis. (10469361)
1999
20
In situ hybridization in the study of remodeling in proliferative glomerulonephritis. (9502386)
1998
21
Urinary erythrophagocytes in proliferative glomerulonephritis. (9750096)
1998
22
A quantitative study of mesangial deposits and glomerular monocytes/macrophages in IgA-nephropathy and proliferative mesangial (non-IgA) glomerulonephritis. (9831239)
1998
23
Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis. (9809476)
1998
24
Mesangial proliferative glomerulonephritis in chronic obstructive pulmonary disease. (10218320)
1998
25
In vitro characterization of the mesangial phenotype in a proliferative glomerulonephritis of the rat. (9430848)
1997
26
Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. (9366565)
1997
27
Therapeutic effect of cytomedicine on mesangio-proliferative glomerulonephritis in human interleukin-6 transgenic mice. (9084882)
1997
28
Proliferative glomerulonephritis revealing chronic Q fever. (8919234)
1996
29
The cytoskeletal linking proteins, moesin and radixin, are upregulated by platelet-derived growth factor, but not basic fibroblast growth factor in experimental mesangial proliferative glomerulonephritis. (8647942)
1996
30
Quantitative analysis of glomeruli lesions in patients with mesangial proliferative glomerulonephritis. (9275704)
1996
31
Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis. (8887282)
1996
32
Nephritic urinary sediment: not only in proliferative glomerulonephritis but also in malignant hypertension. (7617104)
1995
33
Expression of plasminogen activator-inhibitor-1 (PAI-1) during cellular remodeling in proliferative glomerulonephritis in the rat. (7642963)
1995
34
Long-term prognosis and prognostic factors of Japanese children with mesangial proliferative glomerulonephritis without IgA deposition. (7572145)
1995
35
Effect of serum from patients with mesangial proliferative glomerulonephritis on cultured rat mesangial cells. (7900151)
1994
36
Auricular chondritis and diffuse proliferative glomerulonephritis in primary SjAPgren's syndrome. (2782978)
1989
37
Evolution of membranous nephropathy from a proliferative and exudative glomerulonephritis--a report of three cases studied by serial biopsies. (3897088)
1985
38
Siblings with IgA nephropathy and diffuse proliferative glomerulonephritis, without mesangial IgA deposits (PGN), associated with identical HL-A antigens. (6518679)
1984
39
Clinical features and glomerular immunofluorescence of renal biopsies from children with nephrotic syndrome due to minimal change disease and two variants of mesangial proliferative glomerulonephritis. (6370883)
1984
40
Proliferative glomerulonephritis associated with Crohn's disease. (6435761)
1984
41
Acute renal failure and tubular necrosis associated with hematuria due to mesangial proliferative glomerulonephritis. (6525773)
1984
42
Mesangial proliferative glomerulonephritis in children. (7166451)
1982
43
Focal mesangial proliferative glomerulonephritis in the rat caused by Habu venom: the effect of antiplatelet agents. (7000132)
1980
44
Proliferative glomerulonephritis in monoclonal gammopathy. (917180)
1977
45
Extracapillary proliferative glomerulonephritis in children. (1161401)
1975
46
Idiopathic membrano-proliferative glomerulonephritis in children (corrections between light, electron, immunofluorescent microscopic appearances and serum C3 and C4 levels). (4209077)
1973
47
Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis. (5101779)
1971
48
Indomethacin and urinary excretion of fibrinogen-like material in proliferative glomerulonephritis. (5505090)
1970
49
Glomerular fine structure in mixed membranous and proliferative glomerulonephritis. (5483389)
1970
50
Acute degenerative, exudative, and proliferative glomerulonephritis superimposed on chronic diffuse glomerulonephritis. (20269631)
1947

Genetic Variations for Proliferative Glomerulonephritis

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Expression for genes affiliated with Proliferative Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for genes affiliated with Proliferative Glomerulonephritis

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 49PharmGKB, 55SinoBiological
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Pathways related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.3AGTR1
2
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10.1PDGFD, MAPK1
310.1VEGFA, MAPK1
4
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10.0CD79A, MAPK1, CCR5
5
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10.0IL6, MAPK1, CCL2
610.0IL6, MAPK1, CCL2
7
Immune response Oncostatin M signaling via JAK-Stat in human cells
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10.0CCL2, VEGFA, IL6
89.9CXCL9, CXCR3, MAPK1
99.9VEGFA, MAPK1, FGF2
10
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9.9VEGFA, MAPK1, FGF2
11
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.9EDN1, VEGFA, MAPK1
12
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9.9CCR5, CCR1, AGTR1, CXCR3
139.9SELP, THY1, IL6
14
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9.8CCR5, CCL2, MAPK1, IL6
159.8CCL2, EDN1, MAPK1, IL6
16
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9.8IL6, CXCL9, MAPK1, CCL2
179.7IL6, MAPK1, VEGFA, EDN1
189.7CCR5, CCL2, CCR1, CXCR3, CXCL9
199.7FGF2, MAPK1, POLR1A, VEGFA
20
Hide members
9.7CCR5, CCR1, MAPK1, CXCR3, CXCL9
219.6IL6, FGF2, MAPK1, VEGFA, PDGFD
22
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9.5CCR5, CCL2, CCR1, MAPK1, CXCR3, CXCL9
23
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9.5PTPRQ, CXCL9, CXCR3, MAPK1, CCR1, CCR5
24
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9.5CCR5, CCR1, MAPK1, FGF2, CXCR3, TGFB1I1
25
Development PDGF signaling via STATs and NF-kB
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9.5CCL2, AGTR1, MAPK1, FGF2, CXCL9, IL6
26
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9.4CCR5, CCL2, CCR1, EDN1, AGTR1, CXCR3
27
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9.4CCR5, CCL2, CCR1, FGF2, CXCR3, CXCL9
28
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9.3CCR5, CCL2, CCR1, MAPK1, CXCR3, CXCL9
29
Hide members
8.7CCR5, CCL2, CCR1, PDGFD, EDN1, AGTR1

Compounds for genes affiliated with Proliferative Glomerulonephritis

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1pge24410.7VEGFA
2estrogen4410.7CD79A
3suramin44 28 1112.6MAPK1
4rantes4410.5CCR1, IL6, CXCR3
5ccl72810.4CCR1, CXCR3, CCR5
6ccl132810.4CCR1, CXCR3, CCR5
7ccl52810.4CXCR3, CCR5, CCR1
8sdf 14410.3CCL2, CCR5, CXCL9
9valsartan44 59 28 1113.3SELP, CCL2, AGTR1, EDN1
10bucillamine4410.2IL6, FGF2, VEGFA, CD79A
11cyclosporin a44 28 5912.2SELP, EDN1, FGF2, CD79A
12candesartan44 28 1112.2SELP, AGTR1, CCL2, VEGFA
138-isoprostane4410.1AGTR1, CCL2, IL6, EDN1
14triptolide4410.1MAPK1, VEGFA, CCL2, IL6
15ccl444 2811.1CCR5, CCR1, CXCR3, CXCL9, CCL2
16quinapril44 1111.1EDN1, SELP, AGTR1
17creatinine4410.1AGTR1, CXCL9, CXCR3, SELP, CD79A
18mcp 14410.1CXCR3, IL6, CCL2
19groalpha4410.1CXCR3, CXCL9, CCL2, CCR5, IL6
20il 104410.1IL6, CXCL9, CXCR3, CCL2, CCR5
21ang ii4410.1MAPK1, AGTR1, CCL2, VEGFA, EDN1
22tarc4410.0CCR5, CXCL9, CXCR3, CCL2
23infliximab44 49 1112.0VEGFA, FGF2, CXCR3, IL6
24mip 1alpha4410.0CCL2, IL6, CCR5
25fluvastatin44 49 28 1113.0IL6, AGTR1, CCL2, SELP
2615-deoxy-delta-12,14-prostaglandin j24410.0MAPK1, FGF2, CCL2, IL6, VEGFA
27heparin44 28 11 2413.0CXCR3, VEGFA, CD79A, CCR1, CCR5, SELP
28ccl344 2811.0IL6, CXCR3, CCR1, CCR5, CCL2, CXCL9
29shikonin4410.0CCR1, CCL2, CCR5
30gefitinib44 49 1112.0SELP, FGF2, MAPK1
31sodium nitroprusside4410.0SELP, CXCL9, CXCR3, AGTR1, EDN1
32atorvastatin44 49 28 11 2414.0IL6, VEGFA, EDN1, SELP, CCL2
33simvastatin44 49 59 28 11 2414.9CCR5, IL6, SELP, VEGFA, CCL2, AGTR1
34prostacyclin449.9VEGFA, CCL2, FGF2, AGTR1, EDN1, SELP
35isoproterenol44 1110.9AGTR1, CCL2, EDN1, MAPK1, FGF2
36losartan44 49 28 1112.8SELP, EDN1
37n acetylcysteine449.8CCL2, CD79A, IL6, SELP, MAPK1, VEGFA
38polysaccharide449.8CCR5, FGF2, CD79A, SELP, SIGLEC1, CCL2
39pd 98,059449.7IL6, CCL2, EDN1, CXCR3, FGF2, MAPK1
40dexamethasone44 49 28 1112.7IL6, FGF2, CD79A, MAPK1, VEGFA, CXCL9
41sb 20358044 5910.7MAPK1, IL6, FGF2, AGTR1, EDN1, CCL2
42ly294002449.7CXCR3, CCL2, VEGFA, SELP, IL6, FGF2
43histamine44 28 2411.6CCL2, CCR5, SELP, IL6, CXCL9, CXCR3
44genistein44 28 59 2 11 2414.6SELP, IL6, FGF2, MAPK1, AGTR1, EDN1
45arginine449.5CCL2, EDN1, SELP, CXCR3, CD79A, AGTR1
46actinomycin d449.5VEGFA, EDN1, CCR1, CCL2, CCR5, AGTR1
47phosphatidylinositol449.5CXCR3, CXCL9, FGF2, AGTR1, MAPK1, EDN1
48nitric oxide44 11 2411.4EDN1, CCR1, AGTR1, SELP, IL6, CCL2
49vegf449.1SELP, CCL2, EDN1, AGTR1, VEGFA, MAPK1
50tyrosine448.6CXCR3, THY1, SELP, TGFB1I1, CXCL9, AGTR1

GO Terms for genes affiliated with Proliferative Glomerulonephritis

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16Gene Ontology
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Cellular components related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0SELP, CCR5, CCR1, CD79A, CXCR3, CXCL9
2extracellular regionGO:0055769.0PDGFD, EDN1, VEGFA, FGF2, CXCL9, IL6
3extracellular spaceGO:0056159.0CCL2, EDN1, VEGFA, FGF2, CXCL9, IL6

Biological processes related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of vascular endothelial growth factor productionGO:01057410.5IL6, CCL2
2MAPK import into nucleusGO:00018910.4FGF2, MAPK1
3chemokine-mediated signaling pathwayGO:07009810.4CCR1, CCL2, CCR5
4maternal process involved in parturitionGO:06013710.4EDN1, CCL2
5response to amino acid stimulusGO:04320010.3CCL2, EDN1, IL6
6response to heatGO:00940810.3CCL2, IL6, TGFB1I1
7positive regulation of cell divisionGO:05178110.2FGF2, VEGFA, PDGFD
8positive regulation of endothelial cell proliferationGO:00193810.2CCL2, VEGFA, FGF2
9calcium-mediated signalingGO:01972210.2CCR5, EDN1, AGTR1, CXCR3
10MAPK cascadeGO:00016510.1MAPK1, CCL2, CCR5
11positive regulation of leukocyte migrationGO:00268710.1SELP, VEGFA
12cell surface receptor signaling pathwayGO:00716610.1CCR5, CCL2, CCR1, EDN1, CXCR3
13elevation of cytosolic calcium ion concentrationGO:00720410.1CCR5, CCR1, EDN1, AGTR1, CXCR3
14negative regulation of hormone secretionGO:04688810.0IL6, EDN1
15positive regulation of ERK1 and ERK2 cascadeGO:07037410.0IL6, FGF2, CCR1
16G-protein coupled receptor signaling pathwayGO:00718610.0CXCL9, AGTR1, EDN1, CCL2, CCR5
17angiogenesisGO:00152510.0CCL2, VEGFA, CXCR3, THY1
18cell adhesionGO:0071559.9CCL2, CCR1, CXCR3, SELP, TGFB1I1
19platelet activationGO:0301689.9VEGFA, MAPK1, IL6, SELP
20cell-cell signalingGO:0072679.9CCR5, CCR1, EDN1, CXCL9
21positive regulation of cell proliferationGO:0082849.8EDN1, VEGFA, MAPK1, FGF2, IL6
22chemotaxisGO:0069359.7CCR5, CCL2, CCR1, MAPK1, FGF2, CXCR3
23organ morphogenesisGO:0098879.7CCL2, MAPK1, FGF2
24inflammatory responseGO:0069549.3SELP, CCR5, CCL2, CCR1, NFKBID, CXCR3

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1chemokine (C-C motif) ligand 5 bindingGO:07179110.3CCR1, CCR5
2C-C chemokine receptor activityGO:01649310.2CCR1, CCR5
3chemokine receptor activityGO:00495010.2CCR5, CCR1, CXCR3
4C-C chemokine bindingGO:0199579.9CCR1, CCR5
5heparin bindingGO:0082019.8CCL2, VEGFA, FGF2, SELP
6cytokine activityGO:0051259.7IL6, CXCL9, FGF2, VEGFA, EDN1
7growth factor activityGO:0080839.7PDGFD, VEGFA, FGF2, IL6

Products for genes affiliated with Proliferative Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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39NCIt
40NDF-RT
43NINDS
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46OMIM
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