MCID: PRL003
MIFTS: 49

Proliferative Glomerulonephritis malady

Summaries for Proliferative Glomerulonephritis

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33MalaCards
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MalaCards: Proliferative Glomerulonephritis is related to mesangial proliferative glomerulonephritis and membranous glomerulonephritis. An important gene associated with Proliferative Glomerulonephritis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are p70S6K Signaling and Glioma. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and lung, and related mouse phenotypes are renal/urinary system and nervous system.

Aliases & Classifications for Proliferative Glomerulonephritis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

proliferative glomerulonephritis 8 45 61


External Ids:

Disease Ontology8 DOID:4778
SNOMED-CT57 441815006
NCIt40 C35281

Related Diseases for Proliferative Glomerulonephritis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the acute proliferative glomerulonephritis family:

proliferative glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1mesangial proliferative glomerulonephritis31.7IL6, CD79A
2membranous glomerulonephritis30.9CD79A, CCL2, CCR5
3nephritis30.8THY1, CD79A, CCL2, CXCR3
4systemic lupus erythematosus30.7IL6, CCR5, CCL2, CD79A, CXCR3
5hepatitis c30.5CXCR3, CCR5
6lupus nephritis30.4CD79A, CCR5, CCL2, CXCR3
7arthritis30.4CXCL9, FGF2, CCR1, AGTR1, CCL2, CCR5
8antiphospholipid syndrome30.3CD79A, SELP
9vasculitis30.3SELP, CD79A, CCL2
10acute poststreptococcal glomerulonephritis30.0CD79A
11macroglobulinemia30.0CD79A
12pulmonary disease, chronic obstructive30.0CCR5, IL6, CXCR3, CCL2
13iga glomerulonephritis30.0CCL2, CCR5, IL6, AGTR1, CD79A
14acute proliferative glomerulonephritis10.8
15n syndrome10.6
16immune-complex glomerulonephritis10.4
17cryoglobulinemia10.3
18hepatitis c virus10.3
19membranoproliferative glomerulonephritis10.2
20familial mediterranean fever10.2
21exudative glomerulonephritis10.2
22polymyositis10.2
23steroid-resistant nephrotic syndrome10.2
24heavy chain deposition disease10.2
25hellp syndrome10.0
26crescentic glomerulonephritis10.0
27kimura disease10.0
28hepatitis e10.0
29mixed connective tissue disease10.0
30subacute glomerulonephritis10.0
31small cell carcinoma10.0
32good syndrome10.0
33pharyngitis10.0
34goodpasture syndrome10.0
35lepromatous leprosy10.0
36autoimmune hemolytic anemia10.0
37hepatitis d10.0
38aphthous stomatitis10.0
39polymyalgia rheumatica10.0
40polycystic kidney disease10.0
41legionnaires' disease10.0
42adult syndrome10.0
43mantle cell lymphoma10.0
44hepatitis a10.0
45hemolytic-uremic syndrome10.0
46autosomal dominant disease10.0
47squamous cell carcinoma10.0
48stomatitis10.0
49urticaria10.0
50viral hepatitis10.0

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to proliferative glomerulonephritis

Clinical Features for Proliferative Glomerulonephritis

Drugs & Therapeutics for Proliferative Glomerulonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Proliferative Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Proliferative Glomerulonephritis

Search NIH Clinical Center for Proliferative Glomerulonephritis

Search CenterWatch for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

Anatomical Context for Proliferative Glomerulonephritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Proliferative Glomerulonephritis:

33
Brain, Kidney, Lung, Bone marrow, Prostate, Monocytes, T cells, B cells, Endothelial

Animal Models for Proliferative Glomerulonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Proliferative Glomerulonephritis

Sources:
51PubMed
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Articles related to Proliferative Glomerulonephritis:

(show top 50)    (show all 375)
idTitleAuthorsYear
1
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. (22641568)
2013
2
Proliferative glomerulonephritis with discrete deposition of monoclonal immunoglobulin I^1 CH 2 heavy chain and I_ light chain: a new variant of monoclonal immunoglobulin deposition disease. (23356227)
2013
3
Monoclonal gammopathy-associated proliferative glomerulonephritis. (24182705)
2013
4
Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology. (22641580)
2013
5
Proliferative glomerulonephritis causing acute renal failure in a child with Salmonella septicemia. (23814433)
2013
6
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. (21349934)
2011
7
Proliferative glomerulonephritis with monoclonal IgG deposits recurs or may develop de novo in kidney allografts. (21705124)
2011
8
Renal involvement in leprosy: report of progression from diffuse proliferative to crescentic glomerulonephritis. (20016924)
2010
9
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. (19617668)
2009
10
Th1 and Th17 cells induce proliferative glomerulonephritis. (19820122)
2009
11
Hepatitis C virus-associated type II mixed cryoglobulinemia vasculitis complicated with membranous proliferative glomerulonephritis. (19212913)
2009
12
Acute diffuse proliferative glomerulonephritis with atypical presentation in Sri Lankan adults--clinical features and outcome. (19999795)
2009
13
Bilateral macular sub-retinal fluid and retinal pigment epithelial detachment associated with type 2 membrano-proliferative glomerulonephritis. (18430038)
2008
14
Lupus erythematosus proliferative glomerulonephritis in fetus. (15864920)
2005
15
Effect of lipo-prostaglandin E1 on mesangial proliferative glomerulonephritis in rats. (16463661)
2005
16
All-trans-retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice. (15795517)
2005
17
Mesangial proliferative glomerulonephritis]. (15500128)
2004
18
Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. (15102968)
2004
19
Proliferative "crescentic" glomerulonephritis in a burned patient. (12781619)
2003
20
Severity of systemic lupus erythematosus with diffuse proliferative glomerulonephritis and the ineffectiveness of standard pulse intravenous cyclophosphamide therapy in Jamaican patients. (12945726)
2003
21
Ambulatory blood pressure in patients with mesangial proliferative glomerulonephritis. (11688762)
2001
22
Podocyte injuries exacerbate mesangial proliferative glomerulonephritis. (11737593)
2001
23
Growth factor pathways in proliferative glomerulonephritis. (10847321)
2000
24
Management of idiopathic crescentic and diffuse proliferative glomerulonephritis: evidence-based recommendations. (10369193)
1999
25
Ultrastructural localization of vascular cell adhesion molecule-1 in proliferative and crescentic glomerulonephritis. (8972764)
1996
26
Sequential expression of cellular fibronectin by platelets, macrophages, and mesangial cells in proliferative glomerulonephritis. (8080041)
1994
27
Beneficial effect of low molecular weight heparin ("fragmin") on proteinuria of proliferative glomerulonephritis. (7851042)
1994
28
An immunohistological study of epidermal growth factor receptor and neu receptor and neu receptor expression in proliferative glomerulonephritis. (7909365)
1993
29
Interstitial naive and memory T cells in chronic mesangial proliferative glomerulonephritis. (8502328)
1993
30
Protective role of BCG in the rabbit model of mesangial proliferative glomerulonephritis. (1956554)
1991
31
Kynurenine and mesangial-proliferative glomerulonephritis. (1772101)
1991
32
Clinicopathological features in patients with isolated C3 mesangial proliferative glomerulonephritis. (2129468)
1990
33
Non-IgA mesangial proliferative glomerulonephritis. Clinical and pathological analysis of 77 cases. (2517067)
1989
34
Mesangial proliferative glomerulonephritis in southwestern American Indians. (2609403)
1989
35
Effect of daily energy expenditure on the creatinine clearance and daily urinary protein excretion of patients with mesangial proliferative glomerulonephritis. (2739120)
1989
36
Proliferative glomerulonephritis and exposure to organic solvents. (4000345)
1985
37
Mesangial proliferative glomerulonephritis with unusual intramembranous granular dense deposits. (6188567)
1983
38
A case of membranous proliferative glomerulonephritis type III (Burkholder) with the deposition of both HBeAg and HBsAg. (6363317)
1983
39
Nephrotic syndrome and diffuse mesangial proliferative glomerulonephritis in children. (6849298)
1983
40
Transformation of diffuse proliferative glomerulonephritis to membranous nephritis in a patient with systemic lupus erythematosus. (7266728)
1981
41
Proliferative glomerulonephritis associated with levamisole therapy of rheumatoid arthritis. (7288773)
1981
42
Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits. (158675)
1979
43
Mesangial proliferative glomerulonephritis. (355724)
1978
44
A controlled trial of cyclophosphamide in the treatment of proliferative glomerulonephritis. (1105560)
1975
45
Characterization of mixed membranous and proliferative glomerulonephritis: recognition of three varieties. (4620927)
1973
46
Biochemical structure of glomerular basement membrane in chroni glomerulonephritis. I. Lobular and membrano-proliferative glomerulonephritis. (4671225)
1972
47
Immunosuppressive treatment of proliferative glomerulonephritis. (4935362)
1971
48
Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy. (4186205)
1969
49
ACUTE DIFFUSE PROLIFERATIVE GLOMERULONEPHRITIS; PATHOGENESIS. (14119850)
1964
50
Experimental production of diffuse proliferative glomerulonephritis utilizing arteriovenous fistula stress with bacteremia. (14870272)
1951

Genetic Variations for Proliferative Glomerulonephritis

Expression for genes affiliated with Proliferative Glomerulonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for genes affiliated with Proliferative Glomerulonephritis

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 50PharmGKB, 56SinoBiological
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Pathways related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3AGTR1
2
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10.1PDGFD, MAPK1
310.1VEGFA, MAPK1
4
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10.0CD79A, MAPK1, CCR5
5
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10.0IL6, MAPK1, CCL2
610.0IL6, MAPK1, CCL2
7
Immune response Oncostatin M signaling via JAK-Stat in human cells
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10.0CCL2, VEGFA, IL6
89.9CXCL9, CXCR3, MAPK1
99.9VEGFA, MAPK1, FGF2
10
Hide members
9.9VEGFA, MAPK1, FGF2
11
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.9EDN1, VEGFA, MAPK1
12
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9.9CCR5, CCR1, AGTR1, CXCR3
139.9SELP, THY1, IL6
14
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9.8CCR5, CCL2, MAPK1, IL6
159.8CCL2, EDN1, MAPK1, IL6
16
Hide members
9.8IL6, CXCL9, MAPK1, CCL2
179.7IL6, MAPK1, VEGFA, EDN1
189.7CCR5, CCL2, CCR1, CXCR3, CXCL9
199.7FGF2, MAPK1, POLR1A, VEGFA
20
Hide members
9.7CCR5, CCR1, MAPK1, CXCR3, CXCL9
219.6IL6, FGF2, MAPK1, VEGFA, PDGFD
22
Hide members
9.5CCR5, CCL2, CCR1, MAPK1, CXCR3, CXCL9
23
Hide members
9.5PTPRQ, CXCL9, CXCR3, MAPK1, CCR1, CCR5
24
Hide members
9.5CCR5, CCR1, MAPK1, FGF2, CXCR3, TGFB1I1
25
Development PDGF signaling via STATs and NF-kB
Hide members
9.5CCL2, AGTR1, MAPK1, FGF2, CXCL9, IL6
26
Hide members
9.4CCR5, CCL2, CCR1, EDN1, AGTR1, CXCR3
27
Hide members
9.4CCR5, CCL2, CCR1, FGF2, CXCR3, CXCL9
28
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9.3CCR5, CCL2, CCR1, MAPK1, CXCR3, CXCL9
29
Hide members
8.7CCR5, CCL2, CCR1, PDGFD, EDN1, AGTR1

Compounds for genes affiliated with Proliferative Glomerulonephritis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1pge24510.7VEGFA
2estrogen4510.7CD79A
3suramin45 29 1112.6MAPK1
4rantes4510.5CCR1, IL6, CXCR3
5ccl72910.4CCR1, CXCR3, CCR5
6ccl132910.4CCR1, CXCR3, CCR5
7ccl52910.4CXCR3, CCR5, CCR1
8sdf 14510.3CCL2, CCR5, CXCL9
9valsartan45 60 29 1113.3SELP, CCL2, AGTR1, EDN1
10bucillamine4510.2IL6, FGF2, VEGFA, CD79A
11cyclosporin a45 29 6012.2SELP, EDN1, FGF2, CD79A
12candesartan45 29 1112.2SELP, AGTR1, CCL2, VEGFA
138-isoprostane4510.1AGTR1, CCL2, IL6, EDN1
14triptolide4510.1MAPK1, VEGFA, CCL2, IL6
15ccl445 2911.1CCR5, CCR1, CXCR3, CXCL9, CCL2
16quinapril45 1111.1EDN1, SELP, AGTR1
17creatinine4510.1AGTR1, CXCL9, CXCR3, SELP, CD79A
18mcp 14510.1CXCR3, IL6, CCL2
19groalpha4510.1CXCR3, CXCL9, CCL2, CCR5, IL6
20il 104510.1IL6, CXCL9, CXCR3, CCL2, CCR5
21ang ii4510.1MAPK1, AGTR1, CCL2, VEGFA, EDN1
22tarc4510.0CCR5, CXCL9, CXCR3, CCL2
23infliximab45 50 1112.0VEGFA, FGF2, CXCR3, IL6
24mip 1alpha4510.0CCL2, IL6, CCR5
25fluvastatin45 50 29 1113.0IL6, AGTR1, CCL2, SELP
2615-deoxy-delta-12,14-prostaglandin j24510.0MAPK1, FGF2, CCL2, IL6, VEGFA
27heparin45 29 11 2413.0CXCR3, VEGFA, CD79A, CCR1, CCR5, SELP
28ccl345 2911.0IL6, CXCR3, CCR1, CCR5, CCL2, CXCL9
29shikonin4510.0CCR1, CCL2, CCR5
30gefitinib45 50 1112.0SELP, FGF2, MAPK1
31sodium nitroprusside4510.0SELP, CXCL9, CXCR3, AGTR1, EDN1
32atorvastatin45 50 29 11 2414.0IL6, VEGFA, EDN1, SELP, CCL2
33simvastatin45 50 60 29 11 2414.9CCR5, IL6, SELP, VEGFA, CCL2, AGTR1
34prostacyclin459.9VEGFA, CCL2, FGF2, AGTR1, EDN1, SELP
35isoproterenol45 1110.9AGTR1, CCL2, EDN1, MAPK1, FGF2
36losartan45 50 29 1112.8SELP, EDN1
37n acetylcysteine459.8CCL2, CD79A, IL6, SELP, MAPK1, VEGFA
38polysaccharide459.8CCR5, FGF2, CD79A, SELP, SIGLEC1, CCL2
39pd 98,059459.7IL6, CCL2, EDN1, CXCR3, FGF2, MAPK1
40dexamethasone45 50 29 1112.7IL6, FGF2, CD79A, MAPK1, VEGFA, CXCL9
41sb 20358045 6010.7MAPK1, IL6, FGF2, AGTR1, EDN1, CCL2
42ly294002459.7CXCR3, CCL2, VEGFA, SELP, IL6, FGF2
43histamine45 29 2411.6CCL2, CCR5, SELP, IL6, CXCL9, CXCR3
44genistein45 29 60 2 11 2414.6SELP, IL6, FGF2, MAPK1, AGTR1, EDN1
45arginine459.5CCL2, EDN1, SELP, CXCR3, CD79A, AGTR1
46actinomycin d459.5VEGFA, EDN1, CCR1, CCL2, CCR5, AGTR1
47phosphatidylinositol459.5CXCR3, CXCL9, FGF2, AGTR1, MAPK1, EDN1
48nitric oxide45 11 2411.4EDN1, CCR1, AGTR1, SELP, IL6, CCL2
49vegf459.1SELP, CCL2, EDN1, AGTR1, VEGFA, MAPK1
50tyrosine458.6CXCR3, THY1, SELP, TGFB1I1, CXCL9, AGTR1

GO Terms for genes affiliated with Proliferative Glomerulonephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0SELP, CCR5, CCR1, CD79A, CXCR3, CXCL9
2extracellular regionGO:0055769.0PDGFD, EDN1, VEGFA, FGF2, CXCL9, IL6
3extracellular spaceGO:0056159.0CCL2, EDN1, VEGFA, FGF2, CXCL9, IL6

Biological processes related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of vascular endothelial growth factor productionGO:01057410.5IL6, CCL2
2MAPK import into nucleusGO:00018910.4FGF2, MAPK1
3chemokine-mediated signaling pathwayGO:07009810.4CCR1, CCL2, CCR5
4maternal process involved in parturitionGO:06013710.4EDN1, CCL2
5response to amino acid stimulusGO:04320010.3CCL2, EDN1, IL6
6response to heatGO:00940810.3CCL2, IL6, TGFB1I1
7positive regulation of cell divisionGO:05178110.2FGF2, VEGFA, PDGFD
8positive regulation of endothelial cell proliferationGO:00193810.2CCL2, VEGFA, FGF2
9calcium-mediated signalingGO:01972210.2CCR5, EDN1, AGTR1, CXCR3
10MAPK cascadeGO:00016510.1MAPK1, CCL2, CCR5
11positive regulation of leukocyte migrationGO:00268710.1SELP, VEGFA
12cell surface receptor signaling pathwayGO:00716610.1CCR5, CCL2, CCR1, EDN1, CXCR3
13elevation of cytosolic calcium ion concentrationGO:00720410.1CCR5, CCR1, EDN1, AGTR1, CXCR3
14negative regulation of hormone secretionGO:04688810.0IL6, EDN1
15positive regulation of ERK1 and ERK2 cascadeGO:07037410.0IL6, FGF2, CCR1
16G-protein coupled receptor signaling pathwayGO:00718610.0CXCL9, AGTR1, EDN1, CCL2, CCR5
17angiogenesisGO:00152510.0CCL2, VEGFA, CXCR3, THY1
18cell adhesionGO:0071559.9CCL2, CCR1, CXCR3, SELP, TGFB1I1
19platelet activationGO:0301689.9VEGFA, MAPK1, IL6, SELP
20cell-cell signalingGO:0072679.9CCR5, CCR1, EDN1, CXCL9
21positive regulation of cell proliferationGO:0082849.8EDN1, VEGFA, MAPK1, FGF2, IL6
22chemotaxisGO:0069359.7CCR5, CCL2, CCR1, MAPK1, FGF2, CXCR3
23organ morphogenesisGO:0098879.7CCL2, MAPK1, FGF2
24inflammatory responseGO:0069549.3SELP, CCR5, CCL2, CCR1, NFKBID, CXCR3

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1chemokine (C-C motif) ligand 5 bindingGO:07179110.3CCR1, CCR5
2C-C chemokine receptor activityGO:01649310.2CCR1, CCR5
3chemokine receptor activityGO:00495010.2CCR5, CCR1, CXCR3
4C-C chemokine bindingGO:0199579.9CCR1, CCR5
5heparin bindingGO:0082019.8CCL2, VEGFA, FGF2, SELP
6cytokine activityGO:0051259.7IL6, CXCL9, FGF2, VEGFA, EDN1
7growth factor activityGO:0080839.7PDGFD, VEGFA, FGF2, IL6

Products for genes affiliated with Proliferative Glomerulonephritis

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Sources for Proliferative Glomerulonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet