MCID: PRL011
MIFTS: 44

Proliferative Vitreoretinopathy malady

Summaries for Proliferative Vitreoretinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous... more...

MalaCards: Proliferative Vitreoretinopathy, also known as proliferative vitreo-retinopathy, is related to retinitis and retinal detachment. An important gene associated with Proliferative Vitreoretinopathy is NTF4 (neurotrophin 4), and among its related pathways are The retinoid cycle in cones (daylight vision) and the visual cycle I (vertebrates). The compounds retinaldehyde and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial.

Aliases & Classifications for Proliferative Vitreoretinopathy

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

proliferative vitreoretinopathy 8 10 60
proliferative vitreo-retinopathy 60
vitreoretinopathy proliferative 44
retinitis proliferans 8


External Ids:

Disease Ontology8 DOID:9719
MeSH34 D018630

Related Diseases for Proliferative Vitreoretinopathy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Proliferative Vitreoretinopathy:



Diseases related to proliferative vitreoretinopathy

Clinical Features for Proliferative Vitreoretinopathy

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Drugs & Therapeutics for Proliferative Vitreoretinopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Proliferative Vitreoretinopathy

Search CenterWatch for Proliferative Vitreoretinopathy

Genetic Tests for Proliferative Vitreoretinopathy

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Anatomical Context for Proliferative Vitreoretinopathy

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32MalaCards
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MalaCards organs/tissues related to Proliferative Vitreoretinopathy:

32
Retina, Eye, Endothelial, Breast, Monocytes, Placenta

Animal Models for Proliferative Vitreoretinopathy or affiliated genes

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Publications for Proliferative Vitreoretinopathy

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50PubMed
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Articles related to Proliferative Vitreoretinopathy:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: the Retina 4 Project. (23207172)
2013
2
Surgical management of fibrotic encapsulation of the fluocinolone acetonide implant in CAPN5-associated proliferative vitreoretinopathy. (23785231)
2013
3
Perfluorocarbon liquid for dissection of proliferative vitreoretinopathy: avoiding subretinal persistence. (23946882)
2013
4
Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy. (21691136)
2012
5
Prediction of proliferative vitreoretinopathy after retinal detachment surgery: potential of biomarker profiling. (22541653)
2012
6
Activation of neural progenitor cells in human eyes with proliferative vitreoretinopathy. (22465407)
2012
7
Elucidation of the pathogenic mechanism of rhegmatogenous retinal detachment with proliferative vitreoretinopathy by proteomic analysis. (23139279)
2012
8
Relaxing retinotomies and retinectomies in the management of retinal detachment with severe proliferative vitreoretinopathy (PVR). (20957056)
2010
9
High-speed, high-resolution spectral optical coherence tomography in patients after vitrectomy with internal limiting membrane peeling for proliferative vitreoretinopathy retinal detachment. (20182404)
2010
10
Elevated erythropoietin in vitreous of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy. (19602911)
2009
11
Progress in studies on effects of extracellular matrix in occurrence of proliferative vitreoretinopathy]. (19115640)
2008
12
Retinal redetachment after silicone oil removal in proliferative vitreoretinopathy: a prognostic factor analysis. (18191093)
2008
13
HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer. (18587674)
2008
14
Oxane HD vs silicone oil and scleral buckle in retinal detachment with proliferative vitreoretinopathy and inferior retinal breaks. (18369656)
2008
15
Cytokine gene polymorphisms in retinal detachment patients with and without proliferative vitreoretinopathy: a preliminary study. (16704689)
2006
16
Levels of pentosidine in the vitreous of eyes with proliferative diabetic retinopathy, proliferative vitreoretinopathy and retinal detachment. (15947940)
2005
17
Diverse NF-kappaB expression in epiretinal membranes after human diabetic retinopathy and proliferative vitreoretinopathy. (14737065)
2004
18
How to predict proliferative vitreoretinopathy: a prospective study. (11425672)
2001
19
The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinases, on a subacute model of proliferative vitreoretinopathy. (10980656)
2000
20
Elevated levels of calcitonin gene-related peptide in aqueous humor of patients with proliferative vitreoretinopathy. (10796039)
2000
21
Hepatocyte growth factor levels in the vitreous of patients with proliferative vitreoretinopathy. (10844070)
2000
22
Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. (9888438)
1999
23
Cell composition and immunohistochemical detection of VEGF, TGF-beta, and TNF-alpha in proliferative vitreoretinopathy. (10626004)
1999
24
A rabbit model of proliferative vitreoretinopathy induced by injection of astrocytic cultures. (10456236)
1999
25
Osseous metaplasia in proliferative vitreoretinopathy. (9559746)
1998
26
Induction of arachidonic acid metabolite release by human fibroblasts in proliferative vitreoretinopathy. (9489863)
1998
27
Intercellular adhesion molecule-1 in proliferative vitreoretinopathy. (9113001)
1997
28
Role of interleukin 8 in the pathogenesis of proliferative vitreoretinopathy. (9216011)
1997
29
The role of retinotomy in an experimental rabbit model of proliferative vitreoretinopathy. (9154379)
1997
30
Porcine model of proliferative vitreoretinopathy with platelets. (9192164)
1997
31
Anterior proliferative vitreoretinopathy in the silicone study. Silicone Study Report Number 10. (8684799)
1996
32
Macular pucker after successful surgery for proliferative vitreoretinopathy. Silicone Study Report 8. (9098292)
1995
33
Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene. Can proliferative vitreoretinopathy be a target of gene therapy? (9097787)
1995
34
Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. (8129669)
1994
35
Localization and quantitation of blood-retinal barrier breakdown in experimental proliferative vitreoretinopathy. (8285878)
1994
36
The role of fibronectin, laminin, vitronectin and their receptors on cellular adhesion in proliferative vitreoretinopathy. (7514582)
1994
37
Corticosteroids and daunomycin in the prevention of experimental proliferative vitreoretinopathy induced by macrophages. (8444357)
1993
38
Antiproliferative effect of retinoic acid in intravitreous silicone oil in an animal model of proliferative vitreoretinopathy. (8449673)
1993
39
Transferrin receptor expression by retinal pigment epithelial cells in proliferative vitreoretinopathy. (1382045)
1992
40
Induction of experimental proliferative vitreoretinopathy in the rabbit eye by intravitreal injections of fibroblast growth factor. (1284520)
1992
41
Subretinal membranes in proliferative vitreoretinopathy. An immunohistochemical study. (1280852)
1992
42
Cytokines in proliferative vitreoretinopathy. (1800167)
1991
43
Perfluoro-octane in the treatment of giant retinal tears with proliferative vitreoretinopathy. (1800921)
1991
44
The pathology of anterior (peripheral) proliferative vitreoretinopathy. (2979021)
1988
45
Anterior proliferative vitreoretinopathy. Clinicopathologic, light microscopic, and ultrastructural findings. (3226683)
1988
46
Bovine RPE heterotransplants simulate proliferative vitreoretinopathy (PVR) in rabbits. (3509276)
1987
47
Classification of the stages of proliferative vitreoretinopathy in a refined experimental model in the rabbit eye. (3653728)
1987
48
Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment. (3653718)
1987
49
Proliferative vitreoretinopathy. Histopathology of retroretinal membranes. (3628996)
1987
50
Radical vitrectomy and silicone-oil injection in the treatment of proliferative vitreoretinopathy following retinal detachment. (3582093)
1986

Genetic Variations for Proliferative Vitreoretinopathy

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Expression for genes affiliated with Proliferative Vitreoretinopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proliferative Vitreoretinopathy

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Pathways for genes affiliated with Proliferative Vitreoretinopathy

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
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Compounds for genes affiliated with Proliferative Vitreoretinopathy

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1retinaldehyde4410.7RLBP1, RBP3, GFAP
2cycloheximide4410.7RBP3, ITGAX
3streptozotocin4410.6ADM, GFAP, NUDT6
4forskolin44 49 1112.6NTF4, IGFBP6, NUDT6, GFAP, ADM
5bibn 4096 bs4410.6ADM, GPR182
6n-formylmethionyl-leucylphenylalanine4410.6VTN, GFAP, ITGAX
7lactate4410.5CA3, NUDT6, GFAP, VTN, ADM
8arginine4410.5KLK11, NTF4, NUDT6, GFAP, VTN, ADM
9cysteine4410.5KLK11, CA3, GREM1, NUDT6, GFAP, VTN
10retinoic acid44 2411.5ADM, RLBP1, RBP3, ITGAX, NTF4, IGFBP6
11matrigel4410.5NUDT6, GFAP, VTN, ADM
12dbc-amp4410.4ADM, GFAP, NUDT6
13calcium44 49 11 2413.4KLK11, CCL21, NPY1R, C4B, NTF4, IGFBP6
14glutamate4410.4RLBP1, KLK11, NTF4, NUDT6, GFAP, VTN
1511-cis-retinol44 2411.4RBP3, RLBP1
16tyrosine4410.4GREM1, NTF4, IGFBP6, NUDT6, GPR182, GFAP
17phosphatidylinositol4410.3ADM, VTN, NUDT6, NTF4, RLBP1
18acetylcholine44 49 28 11 2414.3NTF4, NUDT6, GFAP, ADM
19dexamethasone44 49 28 1113.0GREM1, IGFBP6, GFAP, VTN, ADM

GO Terms for genes affiliated with Proliferative Vitreoretinopathy

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16Gene Ontology
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Cellular components related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.2CCL21, C4B, RBP3, NTF4, IGFBP6, VTN
2extracellular spaceGO:0056159.9ADM, CCL21, C4B, RBP3, GREM1, IGFBP6

Biological processes related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.4VTN, C4B
2neuron projection regenerationGO:03110210.4ADM, GFAP
3positive regulation of receptor-mediated endocytosisGO:04826010.3VTN, CCL21
4immune responseGO:00695510.0CCL21, LST1, NCR3, VTN

Products for genes affiliated with Proliferative Vitreoretinopathy

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Sources for Proliferative Vitreoretinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet