Proliferative Vitreoretinopathy malady

Wikipedia: Proliferative Vitreo Retinopathy (PVR) is a disease that develops as a complication, secondary to...⁴⁴ more...

MalaCards: Proliferative Vitreoretinopathy, also known as proliferative vitreo-retinopathy, is related to proliferative diabetic retinopathy and retinal detachment. An important gene associated with Proliferative Vitreoretinopathy is TTC36 (tetratricopeptide repeat domain 36), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Glioma Invasiveness. The compounds glycosaminoglycan and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include retina, breast and endothelial, and related mouse phenotypes are craniofacial and respiratory system.

Aliases & Descriptions:

proliferative vitreoretinopathy 6 8 43 proliferative vitreo-retinopathy 43

vitreoretinopathy proliferative 32 retinitis proliferans 6

Diseases related to proliferative vitreoretinopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 775)

id	Related Disease	Score	Top Affiliating Genes
1	proliferative diabetic retinopathy	26.9	VTN, SERPINF1, VEGFA, VCAM1, MIF, FGF2
2	retinal detachment	26.2	SERPINF1, VIM, VEGFA, MTERFD1, MMP3, FN1
3	breast cancer	25.5	VEGFA, MMP3, IL1B, IL6, IL8, IFNG
4	diabetic retinopathy	24.7	VTN, RBP3, SERPINF1, VIM, VEGFA, VCAM1
5	vitreoretinopathy	22.3	NCR3, VTN, PCNA, RBP3, SERPINF1, VIM
6	retinitis	20.2	VTN, PCNA, RBP3, SERPINF1, VIM, VEGFA
7	interval angle-closure glaucoma	13.7	GPR182, SPARC, NTF4, TGFB2, HGF
8	renal hypertension	13.7	GPR182, KNG1, ADM
9	cerebellar medulloblastoma	13.6	PCNA, RBP3, GFAP
10	diabetic angiopathy	13.5	BMP6, FN1, CCL2, ADM
11	chronic ulcer of skin	13.5	CD36, FGF2, PDGFB, TIMP2
12	coronary arteriosclerosis	13.4	IL6, CCL2, HGF
13	myxopapillary ependymoma	13.4	VIM, CA2, GFAP
14	extrinsic allergic alveolitis	13.4	FN1, IL8, CCL2, TGFB2
15	renal vascular disease	13.4	VEGFA, HSPA8, CTGF
16	retinal vascular disease	13.4	SERPINF1, VEGFA, CTGF
17	multiple myeloma	13.3	VTN, FN1, IL6
18	adrenocortical carcinoma	13.3	FGF2, EDNRB, HBEGF, TGFBR2, ADM, EPO
19	clear cell chondrosarcoma	13.3	VIM, CD36, SPARC
20	ischemic heart disease	13.3	HSPA8, EDNRB, HBEGF, NUDT6, KNG1, ADM
21	uterine fibroid	13.3	PCNA, CTGF, THBS1, ADM
22	renal osteodystrophy	13.3	CD36, IL6, IL6R, IGFBP6, EPO
23	secondary syphilis	13.3	CD36, FOS, IL6R, CCL4, SPARC, LTA
24	mixed glioma	13.3	VIM, HSPA4, GFAP
25	nodular regenerative hyperplasia	13.3	PCNA, IL6, IL6R
26	porphyria cutanea tarda	13.3	BMP6, CD36, TFRC, EPO
27	congestive heart failure	13.3	FN1, GPR182, KNG1, ADM, EPO
28	fibrous dysplasia	13.3	CD36, FOS, IL6, SPARC
29	bronchitis	13.3	TGFB2, TFRC, KNG1, ADM, EPO
30	parkinson's disease	13.3	SERPINF1, HSPA8, GLUL, NTF4, HBEGF, NUDT6
31	sympathetic ophthalmia	13.3	CCL2, TNF, LTA, TYRP1
32	connective tissue disease	13.2	BMP6, CD36, CTGF, TGFBR2
33	lacrimal duct obstruction	13.2	MMP3, LTA, EDNRB, HBEGF, TGFB2, KNG1
34	gingival hypertrophy	13.2	VIM, MMP3, TIMP2
35	variegate porphyria	13.2	BMP6, CD36, GLUL, TFRC, EPO
36	abdominal aortic aneurysm	13.2	MMP3, CCL2, TIMP1, TIMP2
37	intraocular melanoma	13.2	MET, THBS1, TGFB2, EPHA3
38	nodular goiter	13.2	IL6R, IFNG, HGF
39	epithelial-myoepithelial carcinoma	13.2	PCNA, VIM, GFAP
40	osteofibrous dysplasia	13.2	VIM, CD36, FOS, SPARC
41	alcoholic hepatitis	13.2	IL8, TNF, HGF
42	ulceration of vulva	13.2	FOS, FN1, FGF2, PDGFB, HBEGF, TGFBR2
43	mesangial proliferative glomerulonephritis	13.1	VEGFA, FGF2, IL6, CCL2
44	aneurysm disease	13.1	MMP3, CCL2, TIMP2, TGFBR2, KNG1
45	monoclonal gammopathy of uncertain significance	13.1	IL6, TNF, LTA
46	oral lichen planus	13.1	VCAM1, HSPA4, HSPA8, TIMP2
47	acral lentiginous melanoma	13.1	VIM, MET, TFRC
48	peripheral primitive neuroectodermal tumor	13.1	VIM, ILK, SPARC, EDNRB, TGFBR2
49	anaplastic plasmacytoma	13.1	PCNA, VIM, GFAP
50	myelofibrosis	13.1	BMP6, FGF2, EPO

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to proliferative vitreoretinopathy:

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MGI Mouse Phenotypes related to proliferative vitreoretinopathy:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.2	TYRP1, EDNRB, PDGFC, HPRT1, ILK, GREM1
2	respiratory system phenotype	MP:0005388	10.1	ROBO1, PDGFB, HPRT1, GREM1
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	LTA, HPRT1, IFNG
4	pigmentation phenotype	MP:0001186	9.7	RLBP1, TYRP1, EDNRB, PDGFC, PDGFB, HPRT1
5	embryogenesis phenotype	MP:0005380	9.6	TGFB2, EDNRB, PDGFC, MET, FOS, MTERFD1
6	integument phenotype	MP:0010771	9.3	RLBP1, NPY1R, TYRP1, HBEGF, EDNRB, PDGFC
7	renal/urinary system phenotype	MP:0005367	9.3	ADM, TGFB2, THBS1, EDNRB, PDGFC, PDGFB
8	limbs/digits/tail phenotype	MP:0005371	9.2	NPY1R, TGFB2, THBS1, EDNRB, LTA, CTGF
9	hematopoietic system phenotype	MP:0005397	9.0	EPO, HGF, TFRC, TGFBI, PDGFB, SPARC
10	no phenotypic analysis	MP:0003012	8.9	EDNRB, PDGFB, HPRT1, ILK, MET, ITGAX
11	hearing/vestibular/ear phenotype	MP:0005377	8.5	NFKB1, EDNRB, TYRP1, TGFB2, CTGF, TNC
12	liver/biliary system phenotype	MP:0005370	8.5	EPO, ADM, HPRT1, IFNG, ENTPD5, IL6
13	skeleton phenotype	MP:0005390	8.0	SPARC, ILK, IL6, FGF2, FN1, FOS
14	nervous system phenotype	MP:0003631	7.8	TGFB2, TGFB1, TIMP2, TYRP1, HBEGF, EDNRB
15	normal phenotype	MP:0002873	7.8	TNC, CTGF, PDGFC, HBEGF, GFAP, TGFBR2
16	immune system phenotype	MP:0005387	7.5	MIF, FN1, FOS, MMP3, ITGAX, VIM
17	digestive/alimentary phenotype	MP:0005381	7.1	PDGFC, EDNRB, GFAP, THBS1, TGFB1, TGFB2
18	growth/size phenotype	MP:0005378	7.0	TGFB2, THBS1, TYRP1, GFAP, HBEGF, EDNRB
19	behavior/neurological phenotype	MP:0005386	6.7	LTA, EDNRB, HBEGF, GFAP, TYRP1, TIMP2
20	reproductive system phenotype	MP:0005389	6.4	HPRT1, TNF, PDGFB, TYRP1, TIMP1, THBS1
21	vision/eye phenotype	MP:0005391	5.8	RLBP1, CCL2, IL6, MET, FGF2, FOS
22	mortality/aging	MP:0010768	5.7	LTA, VCAM1, VEGFA, KCNMA1, MTERFD1, PDGFC
23	tumorigenesis	MP:0002006	5.5	SPARC, EDNRB, TYRP1, TIMP1, THBS1, TGFB1
24	muscle phenotype	MP:0005369	5.5	TNF, HPRT1, CA3, IFNG, CCL2, IL6
25	homeostasis/metabolism phenotype	MP:0005376	4.3	EPO, EPHA3, ADM, KNG1, NPY1R, TFRC
26	cardiovascular system phenotype	MP:0005385	3.6	SERPINF1, VIM, EPO, EPHA3, HGF, ADM
27	cellular phenotype	MP:0005384	2.9	TGFBR2, TGFBI, TGFB2, TGFB1, THBS1, GFAP

Articles related to proliferative vitreoretinopathy:

(show top 50)    (show all 61)

id	Title	Authors	Year	Affiliating Genes
1	Interleukin-6 and the matrix metalloproteinase respon se in the vitreous during proliferative vitreoretinopathy. (21353595)	Symeonidis C.... Dimitrakos S.A.	2011	IL6
2	Kininogen-1 and insulin-like growth factor binding p rotein-6 as serum biomarkers for proliferative vitreoretinopathy]. (21054968)	Wang F.... Cao H.	2010	KNG1, IGFBP6
3	Effect of Robo1 on retinal pigment epithelial cells a nd experimental proliferative vitreoretinopathy. (20071679)	Huang L.... Li X.	2010	ROBO1
4	A strong genetic association between the tumor necros is factor locus and proliferative vitreoretinopathy: the retina 4 project. (20663564)	Rojas J.... Carracedo A.	2010	TNF, LTA, NCR3
5	Elevated erythropoietin in vitreous of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy. (19602911)	Wang Z.Y.... Qu J.	2009	EPO
6	Progress in studies on effects of extracellular matrix in occurrence of proliferative vitreoretinopathy (19115640)	Wang L.H.... Li G.L.	2008	SPARC, THBS1
7	Circulating fibrocytes contribute to the myofibroblast population in proliferative vitreoretinopathy epiretinal membranes. (18441176)	Abu El-Asrar A.M.... Geboes K.	2008	CCL21
8	HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer. (18587674)	Liu Q.... Li J.	2008	HSPA8, HSPA4, TTC36
9	Targeting of integrin-linked kinase with a small interfering RNA suppresses progression of experimental proliferative vitreoretinopathy. (18926819)	Guo L.... Zhao M.	2008	ILK
10	Expression and localisation of BDNF, NT4 and TrkB in proliferative vitreoretinopathy. (18405896)	Ghazi-Nouri S.M.... Charteris D.G.	2008	GFAP, RLBP1, NTF4
11	Blockade of endothelinergic receptors prevents development of proliferative vitreoretinopathy in mice. (18310504)	Iribarne M.... Suburo A.M.	2008	EDNRB
12	Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. (18172073)	Lei H.... Kazlauskas A.	2008	PDGFC
13	The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy. (17724219)	Lee H.... Kane R.	2007	GREM1
14	Intraretinal and periretinal pathology in anterior proliferative vitreoretinopathy. (16612635)	Charteris D.G.... Luthert P.	2007	GFAP
15	Balance of vascular endothelial growth factor and pigment epithelial growth factor prior to development of proliferative vitreoretinopathy. (17534114)	DieudonnAc S.C.... Hendrikse F.	2007	VEGFA, SERPINF1
16	Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. (17194635)	Abu El-Asrar A.M.... Van Damme J.	2006	CCL2
17	Cytokine gene polymorphisms in retinal detachment patients with and without proliferative vitreoretinopathy: a preliminary study. (16704689)	Sanabria Ruiz-Colmenares M.R.... Yugueros Fernandez M.I.	2006	TGFB1, IL6, IFNG
18	Intraretinal immunohistochemistry findings in proliferative vitreoretinopathy with retinal shortening. (16679807)	Pastor J.C.... Gayoso M.J.	2006	GFAP
19	Changes in retinal gene expression in proliferative vitreoretinopathy: glial cell expression of HB-EGF. (15988409)	Hollborn M.... Bringmann A.	2005	VEGFA, GFAP, EPHA3
20	Vascular endothelial growth factor levels in vitreous and serum of patients with either proliferative diabetic retinopathy or proliferative vitreoretinopathy. (15990461)	Sydorova M.... Lee M.S.	2005	VEGFA
21	Interleukin (IL)-6, interleukin (IL)-8 levels and cel lular composition of the vitreous humor in proliferative diabetic retinopathy, proliferative vitreoretinopathy, and traumatic proliferative vitreoretinopathy. (16422002)	Canataroglu H.... Varinli S.	2005	IL8
22	Expression of adrenomedullin and adrenomedullin receptor in the epiretinal membranes of proliferative vitreoretinopathy (15312626)	Huang W.... Hui Y.N.	2004	ADM, GPR182
23	High TGF-beta2 levels during primary retinal detachment may protect against proliferative vitreoretinopathy. (15505063)	DieudonnAc S.C.... Hendrikse F.	2004	HGF, TGFB2
24	Interleukin-8, nitric oxide and glutathione status in proliferative vitreoretinopathy and proliferative diabetic retinopathy. (12920337)	Cicik E.... Ozkan S.	2003	IL8
25	Increased soluble interleukin-6 receptor in vitreous fluid of proliferative vitreoretinopathy. (12789531)	Yamamoto H.... Oshima K.	2003	IL6, IL6R
26	Ribozyme to proliferating cell nuclear antigen to tre at proliferative vitreoretinopathy. (12356843)	Mandava N.... Kruse C.A.	2002	PCNA
27	Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina. (12203398)	Canto Soler M.V.... Suburo A.M.	2002	NPY1R
28	The role of matricellular proteins thrombospondin-1 and osteonectin during RPE cell migration in proliferative vitreoretinopathy. (12658547)	Sheridan C.M.... Grierson I.	2002	TNC, SPARC, THBS1
29	Basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreoretinopathy. (12208248)	La Heij E.C.... Hendrikse F.	2002	FGF2, GLUL
30	Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy. (11264138)	El-Ghrably I.A.... Tighe P.J.	2001	HPRT1
31	Hepatocyte growth factor levels in the vitreous of patients with proliferative vitreoretinopathy. (10844070)	Mitamura Y.... Nishihira J.	2000	HGF
32	Quantitative study of basic fibroblast growth factor in vitreous with proliferative vitreoretinopathy. (12579721)	Liang X.... Li S.	2000	FGF2, NUDT6
33	Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. (9888438)	Lashkari K.... Kazlauskas A.	1999	MET, HGF
34	Soluble cellular adhesion molecules in proliferative vitreoretinopathy and proliferative diabetic retinopathy. (10487959)	Barile G.R.... Schmidt A.M.	1999	VCAM1
35	Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative vitreoretinopathy. (10612518)	Mitamura Y.... Nishihira J.	1999	MIF
36	Cell composition and immunohistochemical detection of VEGF, TGF-beta, and TNF-alpha in proliferative vitreoretinopathy. (10626004)	Toti P.... Tosi G.M.	1999	TNF, VEGFA, BMP6
37	Predominance of MMP-1 and MMP-2 in epiretinal and subretinal membranes of proliferative vitreoretinopathy. (9986746)	Webster L.... Limb G.A.	1999	MMP3, TIMP2, TIMP1
38	Human MA1ller glial cells: altered potassium channel a ctivity in proliferative vitreoretinopathy. (10586958)	Bringmann A.... Reichenbach A.	1999	KCNMA1
39	Expression of vitreous cytokines in proliferative vitreoretinopathy: a prospective study. (10067974)	Kon C.H.... Khaw P.T.	1999	TGFB2
40	Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy. (9872531)	Abe T.... Tamai M.	1998	TYRP1
41	Effects of single, short-term exposures of human reti nal pigment epithelial cells to thiotepa or 5-fluorouracil: implications for th e treatment of proliferative vitreoretinopathy. (9713065)	Kon C.H.... Khaw P.T.	1998	CD36
42	C-C chemokines in the vitreous of patients with proliferative vitreoretinopathy and proliferative diabetic retinopathy. (9869464)	Capeans C.... Salorio M.S.	1998	CCL2, CCL4
43	Detection of vascular endothelial growth factor and tumor necrosis factor alpha in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy and macular pucker. (9787233)	Armstrong D.... Koch F.	1998	VEGFA
44	Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. (8585935)	Elner S.G.... Strieter R.M.	1995	CCL2, IL8
45	The role of fibronectin, laminin, vitronectin and their receptors on cellular adhesion in proliferative vitreoretinopathy. (7514582)	Casaroli Marano R.P.... VilarA^ S.	1994	FN1, VTN
46	Proliferative vitreoretinopathy: an examination of the involvement of lymphocytes, adhesion molecules and HLA-DR antigens. (8339948)	Limb G.A.... Dumonde D.C.	1993	ITGAX
47	Idiopathic proliferative vitreoretinopathy. Activation of microglial cells as the deciding factor (1304218)	Weller M.... Wiedemann P.	1992	ENTPD5
48	Transferrin receptor expression by retinal pigment epithelial cells in proliferative vitreoretinopathy. (1382045)	Baudouin C.... Gastaud P.	1992	TFRC
49	Cytokines in proliferative vitreoretinopathy. (1800167)	Limb G.A.... Dumonde D.C.	1991	IFNG, TGFB2
50	Autoimmune responsiveness to retinal IRBP, S-antigen and opsin in proliferative vitreoretinopathy. (2138091)	Broekhuyse R.M.... Winkens H.J.	1990	RBP3

Genes related to proliferative vitreoretinopathy according to GeneCards:

(show top 50)    (show all 73)

id	Symbol	Description	Score	GeneCards Section Context
1	TTC36	tetratricopeptide repeat domain 36	11.0	Publications
2	GPR182	G protein-coupled receptor 182	11.0	Publications
3	LST1	leukocyte specific transcript 1	11.0	Publications
4	RPE	ribulose-5-phosphate-3-epimerase	11.0
5	RLBP1	retinaldehyde binding protein 1	11.0	Publications
6	RBP3	retinol binding protein 3, interstitial	11.0	Publications
7	NCR3	natural cytotoxicity triggering receptor 3	11.0	Publications
8	NTF4	neurotrophin 4	11.0	Publications
9	GREM1	gremlin 1	11.0	Publications
10	IGFBP6	insulin-like growth factor binding protein 6	11.0	Publications
11	CA3	carbonic anhydrase III, muscle specific	11.0	Publications
12	KLK11	kallikrein-related peptidase 11	11.0	Publications
13	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	11.0	Publications
14	MTERFD1	MTERF domain containing 1	11.0	Disorders
15	TYRP1	tyrosinase-related protein 1	11.0	Publications
16	NPY1R	neuropeptide Y receptor Y1	11.0	Publications
17	ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	11.0	Publications
18	CCL21	chemokine (C-C motif) ligand 21	11.0	Publications
19	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
20	ILK	integrin-linked kinase	11.0	Publications
21	VTN	vitronectin	11.0	Publications
22	TNC	tenascin C	11.0	Publications
23	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
24	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	11.0	Publications
25	THBS1	thrombospondin 1	11.0	Publications
26	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
27	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
28	CA2	carbonic anhydrase II	11.0	Publications
29	ADM	adrenomedullin	11.0	Publications
30	CTGF	connective tissue growth factor	11.0	Publications
31	GFAP	glial fibrillary acidic protein	11.0	Publications
32	GLUL	glutamate-ammonia ligase	11.0	Publications
33	EMP2	epithelial membrane protein 2	11.0
34	EDNRB	endothelin receptor type B	11.0	Publications
35	PDGFC	platelet derived growth factor C	11.0	Publications
36	CCL4	chemokine (C-C motif) ligand 4	11.0	Publications
37	TFRC	transferrin receptor (p90, CD71)	11.0	Publications
38	TGFB2	transforming growth factor, beta 2	11.0	Publications
39	TGFBI	transforming growth factor, beta-induced, 68kDa	11.0
40	PDGFB	platelet-derived growth factor beta polypeptide	11.0
41	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
42	IL6R	interleukin 6 receptor	11.0	Publications
43	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
44	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0	Publications
45	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
46	EPHA3	EPH receptor A3	11.0	Publications
47	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
48	HSPA8	heat shock 70kDa protein 8	11.0	Publications
49	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
50	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications

Pathways related to proliferative vitreoretinopathy according to GeneDecks:

(show top 50)    (show all 147)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.4	CTGF, ITGAX, PDGFC
2	Glioma Invasiveness36	9.7	VTN, BMP6, ITGAX, FGF2, PDGFB, PDGFC
3	PTEN Pathway36	9.6	ITGAX, PDGFB, FN1, FGF2, MET, TNC
4	Paxillin Interactions36	9.3	FGF2, MET, CTGF, PDGFB, ITGAX, PDGFC
5	IL-6 Pathway36	9.2	CCL2, CCL4, BMP6, HGF, TIMP1, CCL21
6	Telomerase Components in Cell Signaling36	9.2	TIMP1, BMP6, HGF, NUDT6, FGF2, MET
7	Ras Pathway36	9.1	ITGAX, FOS, FGF2, MET, CTGF, PDGFB
8	Endothelin-1 Signaling Pathway36	9.1	EPHA3, EDNRB, IL6, IL1B, BMP6, CCL21
9	PPAR Pathway36	8.8	ITGAX, FGF2, MET, IL6, TNF, CTGF
10	JNK Pathway36	8.7	EPHA3, NUDT6, TGFB1, PDGFC, PDGFB, CCL4
11	14-3-3 Induced Intracellular Signaling36	8.5	PDGFB, PDGFC, TIMP1, TGFB1, TGFB2, NUDT6
12	ILK Signaling36	8.5	PDGFB, CTGF, ILK, MET, FGF2, FN1
13	Akt Signaling36	8.3	CCL4, ILK, IL6R, IL6, MET, ITGAX
14	ERK5 Signaling36	8.3	TGFB2, MET, PDGFB, HGF, NUDT6, TGFB1
15	eNOS Signaling36	8.1	EPHA3, HGF, NUDT6, TGFB2, TGFB1, TIMP2
16	p53 Mediated Apoptosis36	8.0	PDGFC, MET, CTGF, HGF, NUDT6, TGFB2
17	MIF Mediated Glucocorticoid Regulation36	7.9	CCL2, CCL4, NFKB1, TNF, CCL21, HGF
18	Nanog in Mammalian ESC Pluripotency36	7.9	TGFB2, TGFB1, HGF, TIMP2, MET, FGF2
19	mTOR Pathway36	7.9	TIMP1, EPHA3, HGF, NUDT6, TGFB2, TGFB1
20	Mitochondrial Apoptosis36	7.9	CTGF, BMP6, FGF2, PDGFB, MET, PDGFC
21	MIF Regulation of Innate Immune Cells36	7.7	BMP6, FOS, MIF, IL1B, IL6, LTA
22	Rac1 Pathway36	7.7	PDGFB, NFKB1, CTGF, IL6, MET, FGF2
23	PEDF Induced Signaling36	7.7	CCL2, CCL21, IL8, IL6, IL1B, FOS
24	DHA Signaling36	7.5	HGF, NUDT6, SERPINF1, BMP6, FGF2, MET
25	Activation of PKC through GPCR36	7.5	PDGFC, TIMP1, TGFB2, HGF, PDGFB, NFKB1
26	Pancreatic Adenocarcinoma36	7.4	TGFBR2, NUDT6, HGF, EPHA3, TGFB2, TGFB1
27	Phospholipase-C Pathway36	7.4	FN1, ITGAX, BMP6, IL6, FGF2, TGFB2
28	Cellular Apoptosis Pathway36	7.3	BMP6, FGF2, MET, IL6, TNF, CTGF
29	ERK Signaling36	7.3	ITGAX, EPHA3, TGFB2, TGFB1, TIMP2, BMP6
30	NFAT in Immune Response36	7.3	IL6, MET, FGF2, FOS, BMP6, TGFB1
31	Molecular Mechanisms of Cancer36	7.3	BMP6, TIMP2, TIMP1, LTA, ITGAX, FOS
32	Estrogen Pathway36	7.3	FGF2, MET, IL6, CTGF, NFKB1, PDGFB
33	GPCR Pathway36	7.2	PDGFC, TGFB2, TGFB1, TIMP2, TIMP1, PDGFB
34	Apoptotic Pathways in Synovial Fibroblasts36	7.2	TIMP2, TGFB1, TGFB2, NUDT6, HGF, TIMP1
35	Renin-Angiotensin Pathway36	7.1	CTGF, NFKB1, PDGFB, PDGFC, TIMP1, TIMP2
36	Malaria20	6.8	VCAM1, CD36, MET, IL1B, IL6, IL8
37	Rheumatoid arthritis20	6.7	CCL2, IFNG, TNF, TGFB1, TGFB2, IL8
38	NF-KappaB (p50-p65) Pathway36	6.6	TGFB1, TGFB2, NUDT6, HGF, TIMP2, TIMP1
39	NF-KappaB Family Pathway36	6.6	BMP6, FGF2, MET, IL1B, IL6, TNF
40	TGF-Beta Pathway36	6.5	FGF2, MET, IL1B, IL6, IL6R, IL8
41	PAK Pathway36	6.4	IL8, CCL4, CCL2, CCL21, TNF, CTGF
42	Chagas disease (American trypanosomiasis)20	6.1	CCL2, IL6, TGFB2, IL1B, IFNG, TNF
43	Cytokine-cytokine receptor interaction20	5.9	IL6, IL6R, IL8, CCL4, CCL2, CCL21
44	MAPK Family Pathway36	5.8	FGF2, MET, IL1B, IL6, IL6R, IL8
45	p38 Signaling36	5.8	LTA, TIMP1, TIMP2, TGFB1, TGFB2, NUDT6
46	MAPK Signaling36	5.8	IL1B, MET, FGF2, FN1, FOS, ITGAX
47	Tec Kinases Signaling36	5.7	IL6R, IL8, CCL4, CCL2, CCL21, TNF
48	Antioxidant Action of Vitamin-C36	5.6	CTGF, TNF, CCL21, CCL2, CCL4, IL8
49	JAK-STAT Pathway36	5.2	IL8, EPO, CCL4, CCL2, CCL21, IFNG
50	Rho Family GTPases36	5.0	TNF, EPHA3, HGF, NUDT6, CTGF, NFKB1

Compounds related to proliferative vitreoretinopathy according to GeneDecks:

(show top 50)    (show all 329)

id	Compound	Score	Top Affiliating Genes
1	glycosaminoglycan32	9.8	FGF2, CD36, VTN, MET, IGFBP6, TNC
2	h2o232	9.6	KCNMA1, MIF, EPHA3, ADM, TFRC, TYRP1
3	agar32	9.6	NUDT6, THBS1, TYRP1, HBEGF, PDGFB, CTGF
4	glucose32	9.4	EPHA3, NUDT6, TGFB2, PDGFB, CTGF, SPARC
5	n acetylcysteine32	9.3	CTGF, FOS, MMP3, VCAM1, PCNA, TIMP1
6	hyaluronic acid32 18	10.3	THBS1, TIMP2, LTA, TNC, FGF2, FN1
7	chondroitin sulfate32 18	10.3	MMP3, CD36, BMP6, VIM, VTN, FN1
8	progesterone32 42 9 18 9	12.9	SPARC, TNC, HSPA4, IGFBP6, CCL4, MET
9	pge232	8.7	ADM, VTN, KNG1, TGFB2, EDNRB, SPARC
10	calcitriol32 42 9 18 9	12.5	FGF2, FOS, CD36, BMP6, CA2, SPARC
11	histamine32 18	9.4	CCL4, IL6R, KCNMA1, BMP6, VCAM1, VIM
12	procollagen32	8.2	SPARC, TNC, MMP3, CD36, BMP6, VIM
13	estrogen32	7.9	EPHA3, ILK, MIF, MMP3, CD36, KCNMA1
14	tgf beta132	7.9	TGFBR2, THBS1, TIMP1, HBEGF, LTA, CTGF
15	adenylate32	7.8	HGF, ADM, KNG1, VCAM1, VIM, KCNMA1
16	losartan32 34 9 9	10.8	TGFB1, TIMP2, EDNRB, CTGF, CCL2, FOS
17	calcium32 9 18 9	10.7	HBEGF, EDNRB, KLK11, LTA, NTF4, CTGF
18	rantes32	7.6	CCL4, IL6R, IL6, MIF, MMP3, BMP6
19	tamoxifen32 34 9 9	10.5	FOS, KCNMA1, BMP6, VCAM1, VEGFA, VIM
20	cysteine32	7.5	TFRC, TGFBR2, TGFBI, TGFB2, THBS1, TIMP2
21	prostacyclin32	7.3	TIMP1, EDNRB, PDGFB, CTGF, TNF, CCL2
22	il 1032	7.2	TGFB1, LTA, TNF, IFNG, CCL2, CCL4
23	testosterone32 9 18 9	10.2	THBS1, PCNA, GFAP, HBEGF, SPARC, HPRT1
24	glutamate32	7.2	HGF, RLBP1, NUDT6, TGFBR2, TGFB2, TIMP1
25	thalidomide32 42 9 9	10.1	TNF, IFNG, IL6R, IL6, IL1B, FGF2
26	ribonucleic acid32	7.1	NUDT6, TGFBR2, TGFB2, TGFB1, THBS1, TIMP2
27	tacrolimus32 34 9 9	10.0	TIMP1, PDGFB, SPARC, TNF, IFNG, CCL4
28	phosphatidylinositol32	6.9	EPO, EPHA3, HGF, ADM, MET, FGF2
29	lipid32	6.9	RLBP1, THBS1, TIMP2, HBEGF, LTA, PDGFB
30	gm-csf32	6.9	EPO, TGFB1, TNF, IFNG, CCL2, IL8
31	vitamin d32	6.8	EPO, HGF, TFRC, TGFBR2, TGFB2, TGFB1
32	15-deoxy-delta-12,14-prostaglandin j232	6.8	HSPA4, IFNG, CCL2, IL8, IL6, IL1B
33	pdtc32	6.8	HGF, TGFB1, TNF, IFNG, CCL2, IL8
34	creatinine32	6.8	EPO, IL6R, MIF, FN1, MMP3, BMP6
35	glutamine32	6.6	CA2, HSPA8, HSPA4, CCL2, IL6R, FN1
36	sb 20358032 42	7.6	TNF, HSPA4, IFNG, CCL4, IL6, FGF2
37	curcumin32	6.3	TGFB1, TIMP1, CTGF, VTN, TNF, HPRT1
38	ly29400232	6.3	TGFB1, THBS1, TIMP2, TIMP1, CTGF, TNF
39	herbimycin a32 42	6.8	CCL2, IL8, IL6, IL1B, MET, FGF2
40	paraffin32	5.6	TIMP2, TIMP1, GFAP, HBEGF, LTA, PDGFB
41	butyrate32	5.4	GLUL, HSPA8, HSPA4, IFNG, IL8, IL6R
42	lactate32	5.4	NUDT6, TFRC, TGFB1, TIMP2, TIMP1, GFAP
43	alanine32	5.3	MET, FGF2, MIF, FN1, MMP3, KCNMA1
44	pd 98,05932	5.2	CCL2, CCL4, IL8, IL6, IL1B, MET
45	retinoic acid32 42 18	7.1	HBEGF, EDNRB, LTA, NTF4, CTGF, SPARC
46	actinomycin d32	4.7	HGF, ADM, KNG1, TFRC, TGFBR2, TGFB1
47	tyrosine32	4.5	LTA, FGF2, MIF, FN1, FOS, MMP3
48	thymidine32 18	5.5	IL6, IL1B, MET, FGF2, MIF, FN1
49	vegf32	3.8	EPO, EPHA3, HGF, ADM, NUDT6, TGFBR2
50	cycloheximide32	3.1	HGF, ADM, KNG1, TFRC, TGFBR2, TGFB2

Cellular components related to proliferative vitreoretinopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	9.5	TGFBI, TGFB2, THBS1, TNC, FN1, SERPINF1
2	external side of plasma membrane	GO:009897	8.7	THBS1, TNF, IFNG, ITGAX, CD36, VCAM1
3	proteinaceous extracellular matrix	GO:005578	8.7	TGFBI, TGFB1, CTGF, SPARC, TNC, FN1
4	platelet alpha granule lumen	GO:031093	8.4	HGF, KNG1, TGFB2, TGFB1, THBS1, TIMP1
5	cell surface	GO:009986	7.4	HBEGF, TIMP2, TGFB1, TGFB2, ROBO1, PDGFB
6	extracellular region	GO:005576	4.3	VTN, TNC, IFNG, IGFBP6, CCL21, CCL2
7	extracellular space	GO:005615	3.8	EPO, CCL2, CCL4, IL8, IL6R, IL6

Biological processes related to proliferative vitreoretinopathy according to GeneDecks:

(show top 50)    (show all 73)

id	Name	GO ID	Score	Top Affiliating Genes
1	monocyte chemotaxis	GO:002548	10.1	PDGFB, CCL2, IL6R, IL6
2	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.1	TGFBR2, THBS1, PDGFB, CD36
3	activation of protein kinase activity	GO:032147	10.1	TGFBR2, TGFB2, PDGFB, VEGFA
4	response to cytokine stimulus	GO:034097	10.1	EPHA3, TGFB2, TIMP1, SPARC, IL6R
5	cell migration involved in sprouting angiogenesis	GO:002042	10.0	ROBO1, GREM1, FGF2, VEGFA
6	positive regulation of osteoblast differentiation	GO:045669	9.9	ILK, IL6R, IL6, FGF2, BMP6
7	positive regulation of endothelial cell proliferation	GO:001938	9.9	PDGFB, CCL2, FGF2, BMP6, VEGFA
8	positive regulation of chemotaxis	GO:050921	9.8	TGFB1, THBS1, PDGFB, CCL21
9	positive regulation of MAPK cascade	GO:043410	9.8	PDGFB, ILK, IL6R, IL6, CD36
10	heart development	GO:007507	9.7	ADM, TGFBR2, TGFB2, PDGFB, SPARC, VCAM1
11	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	HBEGF, PDGFB, TNF, IL6R, IL6
12	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.7	HGF, PDGFB, IL6R, IL6, MIF, CD36
13	positive regulation of angiogenesis	GO:045766	9.6	ADM, THBS1, IL1B, GREM1, FGF2, VEGFA
14	response to progesterone stimulus	GO:032570	9.6	TGFB2, TGFB1, THBS1, CCL2
15	defense response to Gram-positive bacterium	GO:050830	9.6	LTA, TNF, IL6R, IL6, CD36
16	cell proliferation	GO:008283	9.5	EMP2, TGFBI, TGFB2, GLUL, ENTPD5, ILK
17	positive regulation of blood vessel endothelial cell migration	GO:043536	9.5	TGFB1, THBS1, PDGFB, FGF2, VEGFA
18	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.4	FGF2, CCL21, PDGFB, TGFB1
19	negative regulation of growth of symbiont in host	GO:044130	9.4	LTA, TNF, IFNG, CD36
20	cell surface receptor signaling pathway	GO:007166	9.4	EDNRB, IFNG, GPR182, CCL2, MET, MIF
21	angiogenesis	GO:001525	9.4	TGFBI, TGFB2, CTGF, CCL2, IL8, FN1
22	positive regulation of cell migration	GO:030335	9.3	TGFB1, THBS1, HBEGF, PDGFB, ILK, VEGFA
23	neutrophil chemotaxis	GO:030593	9.3	TGFB2, IFNG, CCL2, IL8, IL1B
24	positive regulation of protein kinase B signaling cascade	GO:051897	9.3	TGFB1, THBS1, HBEGF, TNF, CCL21, ILK
25	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.2	PDGFB, CTGF, TNF, CCL21, IL1B, FGF2
26	humoral immune response	GO:006959	9.2	LTA, TNF, IFNG, CCL2, IL6
27	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.2	IL1B, IFNG, TNF
28	cell adhesion	GO:007155	9.1	EPHA3, ROBO1, TGFBI, THBS1, TNC, CCL2
29	response to wounding	GO:009611	9.1	ADM, TGFB2, TGFB1, GFAP, PDGFB, CTGF
30	positive regulation of MAP kinase activity	GO:043406	9.1	VEGFA, ILK, TNF, PDGFB, TGFB1
31	response to glucocorticoid stimulus	GO:051384	9.1	ADM, SPARC, TNF, CCL2, IL6, IL1B
32	positive regulation of interleukin-6 production	GO:032755	9.1	TNF, IL6R, IL6, IL1B, CD36
33	activation of MAPK activity	GO:000187	9.0	HGF, THBS1, TNF, IL1B, MET, FGF2
34	response to estradiol stimulus	GO:032355	9.0	NPY1R, TGFB2, TGFB1, PDGFB, CTGF, IL1B
35	transforming growth factor beta receptor signaling pathway	GO:007179	8.9	TGFBR2, TGFB2, TGFB1, PDGFB, CCL2, FOS
36	positive regulation of cell division	GO:051781	8.8	TGFB2, TGFB1, PDGFC, PDGFB, IL1B, FGF2
37	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.7	TGFB1, TNF, IL6, MET, MIF, VEGFA
38	platelet degranulation	GO:002576	8.6	VEGFA, HGF, KNG1, TGFB2, TGFB1, THBS1
39	negative regulation of apoptotic process	GO:043066	8.5	TGFB2, THBS1, TIMP1, TNF, IL6, MIF
40	protein kinase B signaling cascade	GO:043491	8.3	TGFB1, TNF, CCL2, IL1B
41	platelet activation	GO:030168	8.2	HGF, KNG1, TGFB2, TGFB1, THBS1, TIMP1
42	blood coagulation	GO:007596	8.2	HGF, KNG1, TGFB2, TGFB1, THBS1, TIMP1
43	aging	GO:007568	8.2	EPO, ADM, TGFB2, TGFB1, TIMP1, CCL2
44	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.1	TGFB1, NFKB1, TNF, IL6R, IL6, IL1B
45	response to drug	GO:042493	8.1	TGFBR2, TGFB2, TGFB1, THBS1, LTA, PDGFB
46	positive regulation of cell proliferation	GO:008284	8.0	TIMP1, TGFB1, TGFB2, TGFBR2, ADM, EPO
47	negative regulation of cell proliferation	GO:008285	7.8	ADM, TGFB2, TGFB1, TIMP2, TNF, IGFBP6
48	response to hypoxia	GO:001666	7.6	LTA, THBS1, TGFB1, TGFB2, ADM, PDGFB
49	inflammatory response	GO:006954	7.0	CCL2, CCL21, TNF, NFKB1, TGFB1, KNG1
50	positive regulation of transcription, DNA-dependent	GO:045893	6.4	EPO, TGFB1, PDGFB, NFKB1, TNF, ILK

Molecular functions related to proliferative vitreoretinopathy according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface binding	GO:043498	10.2	PDGFC, PDGFB, MIF, VEGFA
2	chemokine activity	GO:008009	10.0	IL8, CCL4, CCL2, CCL21
3	transforming growth factor beta binding	GO:050431	9.9	TGFBR2, THBS1, CD36
4	integrin binding	GO:005178	9.9	TGFBI, THBS1, TIMP2, GFAP, CTGF, ILK
5	platelet-derived growth factor receptor binding	GO:005161	9.8	VEGFA, PDGFB, PDGFC
6	receptor binding	GO:005102	9.6	ADM, KNG1, TGFB2, LTA, TNC, HSPA8
7	heparin binding	GO:008201	9.5	KNG1, THBS1, HBEGF, CTGF, CCL2, FGF2
8	eukaryotic cell surface binding	GO:043499	9.1	EPO, TGFB1, THBS1, HBEGF, PDGFB
9	protein heterodimerization activity	GO:046982	8.7	HGF, TGFB2, TGFB1, TYRP1, PDGFB, MET
10	protein homodimerization activity	GO:042803	8.5	TGFB2, TGFB1, TYRP1, PDGFC, PDGFB, NFKB1
11	cytokine activity	GO:005125	7.7	CCL4, IFNG, TNF, LTA, TGFB2, IL6
12	growth factor activity	GO:008083	7.7	VEGFA, HGF, NUDT6, TGFB2, TGFB1, HBEGF
13	protein binding	GO:005515	4.0	THBS1, TIMP1, TYRP1, PDGFB, NFKB1, SPARC