MCID: PRL011
MIFTS: 43

Proliferative Vitreoretinopathy malady

Eye diseases category
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Summaries for Proliferative Vitreoretinopathy

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Wikipedia:65 Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous... more...

MalaCards based summary: Proliferative Vitreoretinopathy, also known as proliferative vitreo-retinopathy, is related to proliferative diabetic retinopathy and retinal degeneration. An important gene associated with Proliferative Vitreoretinopathy is NCR3 (natural cytotoxicity triggering receptor 3), and among its related pathways are Visual Cycle in Retinal Rods and the visual cycle I (vertebrates). The compounds 11-cis-retinol and quinolinic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotype nervous system.

Aliases & Classifications for Proliferative Vitreoretinopathy

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Proliferative Vitreoretinopathy, Aliases & Descriptions:

Name: Proliferative Vitreoretinopathy 8 10 62
Proliferative Vitreo-Retinopathy 62
 
Vitreoretinopathy Proliferative 44
Retinitis Proliferans 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:9719
MeSH34 D018630

Related Diseases for Proliferative Vitreoretinopathy

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Diseases related to Proliferative Vitreoretinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative diabetic retinopathy31.0VTN, GFAP
2retinal degeneration29.9RBP3, RLBP1, GFAP
3retinitis11.2
4retinal detachment11.1
5diabetic retinopathy10.8
6endotheliitis10.6
7cataract10.4
8blindness10.3
9fundus albipunctatus10.3RLBP1
10tuberous sclerosis10.2
11telangiectasis10.2
12keloids10.2
13coats disease10.2
14macular holes10.2
15von hippel-lindau disease10.2
16vitreous detachment10.2
17visceral leishmaniasis10.2
18neuronitis10.2
19choroiditis10.2
20breast cancer10.2
21leishmaniasis10.2
22retinal disease10.2
23uveitis10.2
24fundus flavimaculatus10.2
25rhyns syndrome10.0RBP3, RLBP1
26berger disease9.9VTN, NPY1R
27primary hyperoxaluria9.8VTN, GREM1, C4B
28multiple sclerosis9.7C4B, VTN, GFAP
29ischemia9.6VTN, NTF4, GFAP

Graphical network of the top 20 diseases related to Proliferative Vitreoretinopathy:



Diseases related to proliferative vitreoretinopathy

Symptoms for Proliferative Vitreoretinopathy

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Drugs & Therapeutics for Proliferative Vitreoretinopathy

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Drug clinical trials:

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Search NIH Clinical Center for Proliferative Vitreoretinopathy

Genetic Tests for Proliferative Vitreoretinopathy

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Anatomical Context for Proliferative Vitreoretinopathy

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MalaCards organs/tissues related to Proliferative Vitreoretinopathy:

32
Eye, Retina, Endothelial, Breast, Placenta, Monocytes

Animal Models for Proliferative Vitreoretinopathy or affiliated genes

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MGI Mouse Phenotypes related to Proliferative Vitreoretinopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.4NPY1R, RBP3, GREM1, NTF4, RLBP1, GFAP

Publications for Proliferative Vitreoretinopathy

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Articles related to Proliferative Vitreoretinopathy:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Comparison of morphologic features of macular proliferative vitreoretinopathy and idiopathic epimacular membrane. (24736464)
2014
2
Investigating the pathological processes of rhegmatogenous retinal detachment and proliferative vitreoretinopathy with metabolomics analysis. (24556753)
2014
3
Aquaporin-1 expression in proliferative vitreoretinopathy and in epiretinal membranes. (24688444)
2014
4
Anatomic and functional outcomes of 25-gauge vitrectomy for repair of eyes with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy. (24143072)
2013
5
There is no relation between the occurrence of proliferative vitreoretinopathy and the location of the donor site after transplantation of a free autologous retinal pigment epithelium-choroid graft. (23890210)
2013
6
Three hundred and sixty degree retinotomy for retinal detachments with severe proliferative vitreoretinopathy. (23504084)
2013
7
Proliferative vitreoretinopathy and genetic profile. (23825722)
2013
8
Retinotomy with retinal turnover to remove subretinal membranes under direct visualization for proliferative vitreoretinopathy. (22693421)
2012
9
Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy. (21691136)
2012
10
Intravitreal bevacizumab (avastin) combined with vitrectomy for recurrences of proliferative vitreoretinopathy in Von Hippel-Lindau disease. (21649868)
2012
11
Prediction of proliferative vitreoretinopathy after retinal detachment surgery: potential of biomarker profiling. (22541653)
2012
12
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. (19931527)
2010
13
Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment. (19815730)
2010
14
Proliferative vitreoretinopathy: pathobiology and therapeutic targets. (19373688)
2009
15
Development of predictive models of proliferative vitreoretinopathy based on genetic variables: the Retina 4 project. (19098314)
2009
16
Aggregations of retinal pigment epithelial cells on inferior retinal blood vessels, a clinical sign of early proliferative vitreoretinopathy. (19128379)
2008
17
Combined 5-fluorouracil, low-molecular-weight heparin, and silicone oil in the management of complicated retinal detachment with proliferative vitreoretinopathy grade C. (17674917)
2007
18
Influence of relaxing retinotomy on surgical outcomes in proliferative vitreoretinopathy. (16226515)
2005
19
Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy. (15623793)
2005
20
Expression of adrenomedullin and adrenomedullin receptor in the epiretinal membranes of proliferative vitreoretinopathy]. (15312626)
2004
21
Expression of TGF-beta receptor II in periretinal membranes of proliferative vitreoretinopathy]. (14740555)
2003
22
Tenascin-C levels in the vitreous of patients with proliferative vitreoretinopathy. (14573976)
2003
23
A cost-utility analysis of interventions for severe proliferative vitreoretinopathy. (11860974)
2002
24
Role of daunorubicin in inhibiting proliferative vitreoretinopathy after retinal detachment surgery. (12213159)
2002
25
Preservation of anterior capsule during vitrectomy and lensectomy for retinal detachment with proliferative vitreoretinopathy. (11825819)
2002
26
How to predict proliferative vitreoretinopathy: a prospective study. (11425672)
2001
27
Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy. (11264138)
2001
28
Risk factors for proliferative vitreoretinopathy after primary vitrectomy: a prospective study. (10781515)
2000
29
The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy. (10520228)
1999
30
Vitreous levels of intercellular adhesion molecule 1 (ICAM-1) as a risk indicator of proliferative vitreoretinopathy. (10413701)
1999
31
Proliferative vitreoretinopathy: an overview. (9716190)
1998
32
Repair of a complex retinal detachment with proliferative vitreoretinopathy in an eye with extreme scleral thinning. (9639457)
1998
33
Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy. (8843916)
1996
34
Evidence of chronic inflammation in retina excised after relaxing retinotomy for anterior proliferative vitreoretinopathy. (8964525)
1996
35
Vitamin E succinate inhibits proliferation and migration of retinal pigment epithelial cells in vitro: therapeutic implication for proliferative vitreoretinopathy. (8720718)
1996
36
Macular pucker after successful surgery for proliferative vitreoretinopathy. Silicone Study Report 8. (9098292)
1995
37
Proliferative vitreoretinopathy in Coats' disease. Clinicohistopathological case report. (7715928)
1995
38
Suppression of experimental proliferative vitreoretinopathy by sustained intraocular delivery of 5-FU. (8537196)
1995
39
Comparison of flow cytometry with the surgeon regarding ability to predict the ultimate success of surgery for proliferative vitreoretinopathy. (7993210)
1994
40
Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. (8129669)
1994
41
Five-year results of vitrectomy and silicone oil in patients with proliferative vitreoretinopathy. (8115727)
1993
42
Idiopathic proliferative vitreoretinopathy. Activation of microglial cells as the deciding factor]. (1304218)
1992
43
Vitrectomy with silicone oil or perfluoropropane gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 2. (1596225)
1992
44
Transferrin receptor expression by retinal pigment epithelial cells in proliferative vitreoretinopathy. (1382045)
1992
45
Proliferative vitreoretinopathy--is it anything more than wound healing at the wrong place? (2187005)
1990
46
The effect of cryotherapy on proliferative vitreoretinopathy (PVR). (2795935)
1989
47
Proliferative vitreoretinopathy membranes. An immunohistochemical study. (2662102)
1989
48
The validity and reliability of photographic documentation of proliferative vitreoretinopathy. (2652029)
1989
49
Regular silicone and fluorosilicone oil in the prevention of retinal detachment caused by experimental proliferative vitreoretinopathy. (3417389)
1988
50
Proliferative vitreoretinopathy. Ultrastructural study of 20 retroretinal membranes removed by vitreous surgery. (3231920)
1988

Variations for Proliferative Vitreoretinopathy

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Expression for genes affiliated with Proliferative Vitreoretinopathy

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Expression patterns in normal tissues for genes affiliated with Proliferative Vitreoretinopathy

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Pathways for genes affiliated with Proliferative Vitreoretinopathy

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Pathways related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5RBP3, RLBP1
2
Show member pathways
9.5RBP3, RLBP1
3
Show member pathways
9.5RBP3, RLBP1
4
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.4C4B, VTN

Compounds for genes affiliated with Proliferative Vitreoretinopathy

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Compounds related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
111-cis-retinol44 2410.8RBP3, RLBP1
2quinolinic acid44 2410.5GFAP, NTF4
3silicone449.3VTN, GFAP
4formate449.2GFAP, VTN
5n-formylmethionyl-leucylphenylalanine449.1GFAP, VTN
6retinaldehyde449.0RBP3, RLBP1, GFAP
7chondroitin sulfate44 249.9VTN, GFAP
8cisplatin44 50 61 1111.8VTN, NTF4, GFAP
9polyethylene glycol448.7VTN, GFAP
10cycloheximide448.6GFAP, VTN, RBP3
11glutamate448.4VTN, NTF4, RLBP1, GFAP
12glutamine448.3GFAP, RLBP1, VTN, RBP3
13serine448.3C4B, VTN, NTF4, GFAP
14calcium44 50 24 1111.1C4B, NPY1R, VTN, NTF4, GFAP
15retinoic acid44 249.0GFAP, RLBP1, NTF4, VTN, RBP3

GO Terms for genes affiliated with Proliferative Vitreoretinopathy

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Cellular components related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell bodyGO:0442978.8RLBP1, GFAP
2extracellular regionGO:0055768.6C4B, RBP3, VTN, NTF4

Biological processes related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phototransduction, visible lightGO:0076039.5RBP3, RLBP1
2regulation of complement activationGO:0304499.3C4B, VTN
3retinoid metabolic processGO:0015239.2RBP3, RLBP1

Molecular functions related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinol bindingGO:0198419.2RBP3, RLBP1
2integrin bindingGO:0051789.0VTN, GFAP

Products for genes affiliated with Proliferative Vitreoretinopathy

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Sources for Proliferative Vitreoretinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet