MCID: PRL011
MIFTS: 43

Proliferative Vitreoretinopathy malady

Eye diseases category

Summaries for Proliferative Vitreoretinopathy

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66Wikipedia, 34MalaCards
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Wikipedia:66 Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous... more...

MalaCards: Proliferative Vitreoretinopathy, also known as proliferative vitreo-retinopathy, is related to proliferative diabetic retinopathy and retinal degeneration. An important gene associated with Proliferative Vitreoretinopathy is NCR3 (natural cytotoxicity triggering receptor 3), and among its related pathways are Visual Cycle in Retinal Rods and the visual cycle I (vertebrates). The compounds 11-cis-retinol and quinolinic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotype nervous system.

Aliases & Classifications for Proliferative Vitreoretinopathy

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9Disease Ontology, 11DISEASES, 63UMLS, 46Novoseek, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

proliferative vitreoretinopathy 9 11 63
proliferative vitreo-retinopathy 63
vitreoretinopathy proliferative 46
retinitis proliferans 9


External Ids:

Disease Ontology9 DOID:9719
MeSH36 D018630

Related Diseases for Proliferative Vitreoretinopathy

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Proliferative Vitreoretinopathy:



Diseases related to proliferative vitreoretinopathy

Symptoms for Proliferative Vitreoretinopathy

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Drugs & Therapeutics for Proliferative Vitreoretinopathy

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Proliferative Vitreoretinopathy

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Anatomical Context for Proliferative Vitreoretinopathy

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34MalaCards
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MalaCards organs/tissues related to Proliferative Vitreoretinopathy:

34
Eye, Retina, Endothelial, Breast, Placenta, Monocytes

Animal Models for Proliferative Vitreoretinopathy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Proliferative Vitreoretinopathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.4NPY1R, RBP3, GREM1, NTF4, RLBP1, GFAP

Publications for Proliferative Vitreoretinopathy

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53PubMed
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Articles related to Proliferative Vitreoretinopathy:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Anatomic and functional outcomes of 25-gauge vitrectomy for repair of eyes with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy. (24143072)
2013
2
There is no relation between the occurrence of proliferative vitreoretinopathy and the location of the donor site after transplantation of a free autologous retinal pigment epithelium-choroid graft. (23890210)
2013
3
Three hundred and sixty degree retinotomy for retinal detachments with severe proliferative vitreoretinopathy. (23504084)
2013
4
Proliferative vitreoretinopathy and genetic profile. (23825722)
2013
5
Retinotomy with retinal turnover to remove subretinal membranes under direct visualization for proliferative vitreoretinopathy. (22693421)
2012
6
Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy. (21691136)
2012
7
Intravitreal bevacizumab (avastin) combined with vitrectomy for recurrences of proliferative vitreoretinopathy in Von Hippel-Lindau disease. (21649868)
2012
8
Prediction of proliferative vitreoretinopathy after retinal detachment surgery: potential of biomarker profiling. (22541653)
2012
9
Modelling postoperative visual acuity with and without proliferative vitreoretinopathy associated with primary rhegmatogenous retinal detachment. (22878443)
2012
10
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. (19931527)
2010
11
Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment. (19815730)
2010
12
Proliferative vitreoretinopathy: pathobiology and therapeutic targets. (19373688)
2009
13
Development of predictive models of proliferative vitreoretinopathy based on genetic variables: the Retina 4 project. (19098314)
2009
14
Aggregations of retinal pigment epithelial cells on inferior retinal blood vessels, a clinical sign of early proliferative vitreoretinopathy. (19128379)
2008
15
Combined 5-fluorouracil, low-molecular-weight heparin, and silicone oil in the management of complicated retinal detachment with proliferative vitreoretinopathy grade C. (17674917)
2007
16
Influence of relaxing retinotomy on surgical outcomes in proliferative vitreoretinopathy. (16226515)
2005
17
Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy. (15623793)
2005
18
Expression of adrenomedullin and adrenomedullin receptor in the epiretinal membranes of proliferative vitreoretinopathy]. (15312626)
2004
19
Expression of TGF-beta receptor II in periretinal membranes of proliferative vitreoretinopathy]. (14740555)
2003
20
Tenascin-C levels in the vitreous of patients with proliferative vitreoretinopathy. (14573976)
2003
21
A cost-utility analysis of interventions for severe proliferative vitreoretinopathy. (11860974)
2002
22
Role of daunorubicin in inhibiting proliferative vitreoretinopathy after retinal detachment surgery. (12213159)
2002
23
Preservation of anterior capsule during vitrectomy and lensectomy for retinal detachment with proliferative vitreoretinopathy. (11825819)
2002
24
How to predict proliferative vitreoretinopathy: a prospective study. (11425672)
2001
25
Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy. (11264138)
2001
26
Risk factors for proliferative vitreoretinopathy after primary vitrectomy: a prospective study. (10781515)
2000
27
The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy. (10520228)
1999
28
Vitreous levels of intercellular adhesion molecule 1 (ICAM-1) as a risk indicator of proliferative vitreoretinopathy. (10413701)
1999
29
Proliferative vitreoretinopathy: an overview. (9716190)
1998
30
Repair of a complex retinal detachment with proliferative vitreoretinopathy in an eye with extreme scleral thinning. (9639457)
1998
31
Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy. (8843916)
1996
32
Evidence of chronic inflammation in retina excised after relaxing retinotomy for anterior proliferative vitreoretinopathy. (8964525)
1996
33
Vitamin E succinate inhibits proliferation and migration of retinal pigment epithelial cells in vitro: therapeutic implication for proliferative vitreoretinopathy. (8720718)
1996
34
Macular pucker after successful surgery for proliferative vitreoretinopathy. Silicone Study Report 8. (9098292)
1995
35
Proliferative vitreoretinopathy in Coats' disease. Clinicohistopathological case report. (7715928)
1995
36
Suppression of experimental proliferative vitreoretinopathy by sustained intraocular delivery of 5-FU. (8537196)
1995
37
Comparison of flow cytometry with the surgeon regarding ability to predict the ultimate success of surgery for proliferative vitreoretinopathy. (7993210)
1994
38
Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. (8129669)
1994
39
Five-year results of vitrectomy and silicone oil in patients with proliferative vitreoretinopathy. (8115727)
1993
40
Expression of mRNA for interleukin 6 by cells infiltrating epiretinal membranes in proliferative vitreoretinopathy. (8317327)
1993
41
Idiopathic proliferative vitreoretinopathy. Activation of microglial cells as the deciding factor]. (1304218)
1992
42
Vitrectomy with silicone oil or perfluoropropane gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 2. (1596225)
1992
43
Transferrin receptor expression by retinal pigment epithelial cells in proliferative vitreoretinopathy. (1382045)
1992
44
Proliferative vitreoretinopathy--is it anything more than wound healing at the wrong place? (2187005)
1990
45
The effect of cryotherapy on proliferative vitreoretinopathy (PVR). (2795935)
1989
46
Proliferative vitreoretinopathy membranes. An immunohistochemical study. (2662102)
1989
47
The validity and reliability of photographic documentation of proliferative vitreoretinopathy. (2652029)
1989
48
Management of anterior vitreous traction in proliferative vitreoretinopathy. (2629041)
1989
49
Regular silicone and fluorosilicone oil in the prevention of retinal detachment caused by experimental proliferative vitreoretinopathy. (3417389)
1988
50
Proliferative vitreoretinopathy. Ultrastructural study of 20 retroretinal membranes removed by vitreous surgery. (3231920)
1988

Variations for Proliferative Vitreoretinopathy

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Expression for genes affiliated with Proliferative Vitreoretinopathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proliferative Vitreoretinopathy

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Pathways for genes affiliated with Proliferative Vitreoretinopathy

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51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 58SinoBiological
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Pathways related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5RBP3, RLBP1
2
Show member pathways
9.5RBP3, RLBP1
3
Show member pathways
9.5RBP3, RLBP1
4
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.4C4B, VTN

Compounds for genes affiliated with Proliferative Vitreoretinopathy

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46Novoseek, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 12DrugBank
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Compounds related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
111-cis-retinol46 2510.8RBP3, RLBP1
2quinolinic acid46 2510.5GFAP, NTF4
3silicone469.3VTN, GFAP
4formate469.2GFAP, VTN
5n-formylmethionyl-leucylphenylalanine469.1GFAP, VTN
6retinaldehyde469.0RBP3, RLBP1, GFAP
7chondroitin sulfate46 259.9VTN, GFAP
8cisplatin46 52 62 1211.8VTN, NTF4, GFAP
9polyethylene glycol468.7VTN, GFAP
10cycloheximide468.6GFAP, VTN, RBP3
11glutamate468.4VTN, NTF4, RLBP1, GFAP
12glutamine468.3GFAP, RLBP1, VTN, RBP3
13serine468.3C4B, VTN, NTF4, GFAP
14calcium46 52 25 1211.1C4B, NPY1R, VTN, NTF4, GFAP
15retinoic acid46 259.0GFAP, RLBP1, NTF4, VTN, RBP3

GO Terms for genes affiliated with Proliferative Vitreoretinopathy

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17Gene Ontology
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Cellular components related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell bodyGO:0442978.8RLBP1, GFAP
2extracellular regionGO:0055768.6C4B, RBP3, VTN, NTF4

Biological processes related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phototransduction, visible lightGO:0076039.5RBP3, RLBP1
2regulation of complement activationGO:0304499.3C4B, VTN
3retinoid metabolic processGO:0015239.2RBP3, RLBP1

Molecular functions related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinol bindingGO:0198419.2RBP3, RLBP1
2integrin bindingGO:0051789.0VTN, GFAP

Products for genes affiliated with Proliferative Vitreoretinopathy

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  • Antibodies
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Sources for Proliferative Vitreoretinopathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet