MCID: PRL011
MIFTS: 44

Proliferative Vitreoretinopathy malady

Summaries for Proliferative Vitreoretinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous... more...

MalaCards: Proliferative Vitreoretinopathy, also known as proliferative vitreo-retinopathy, is related to retinitis and retinal detachment. An important gene associated with Proliferative Vitreoretinopathy is NTF4 (neurotrophin 4), and among its related pathways are The retinoid cycle in cones (daylight vision) and the visual cycle I (vertebrates). The compounds retinaldehyde and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial.

Aliases & Classifications for Proliferative Vitreoretinopathy

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

proliferative vitreoretinopathy 8 10 60
proliferative vitreo-retinopathy 60
vitreoretinopathy proliferative 44
retinitis proliferans 8


External Ids:

Disease Ontology8 DOID:9719
MeSH34 D018630

Related Diseases for Proliferative Vitreoretinopathy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Proliferative Vitreoretinopathy:



Diseases related to proliferative vitreoretinopathy

Clinical Features for Proliferative Vitreoretinopathy

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Drugs & Therapeutics for Proliferative Vitreoretinopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Proliferative Vitreoretinopathy

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Genetic Tests for Proliferative Vitreoretinopathy

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Anatomical Context for Proliferative Vitreoretinopathy

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32MalaCards
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MalaCards organs/tissues related to Proliferative Vitreoretinopathy:

32
Retina, Eye, Endothelial, Breast, Monocytes, Placenta

Animal Models for Proliferative Vitreoretinopathy or affiliated genes

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Publications for Proliferative Vitreoretinopathy

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50PubMed
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Articles related to Proliferative Vitreoretinopathy:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Anatomic and functional outcomes of 25-gauge vitrectomy for repair of eyes with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy. (24143072)
2013
2
Three hundred and sixty degree retinotomy for retinal detachments with severe proliferative vitreoretinopathy. (23504084)
2013
3
Pars plana vitrectomy with medium-term postoperative perfluoro-N-octane for recurrent inferior retinal detachment complicated by advanced proliferative vitreoretinopathy. (23117281)
2013
4
Rhegmatogenous Retinal Detachment with a High Risk of Proliferative Vitreoretinopathy Treated with Episcleral Surgery and an Intravitreal Dexamethasone 0.7-mg Implant. (23687501)
2013
5
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. (19931527)
2010
6
Glial cell changes of the human retina in proliferative vitreoretinopathy. (19494651)
2009
7
Retinal detachment and proliferative vitreoretinopathy: ophthalmic artery blood velocities, intraocular pressure, and endothelin-1. (18185147)
2008
8
Proliferative vitreoretinopathy. (17822994)
2007
9
siRNA targeting mammalian target of rapamycin (mTOR) attenuates experimental proliferative vitreoretinopathy. (18027173)
2007
10
Inhibition of experimental proliferative vitreoretinopathy with protein kinase C inhibitor (chelerythrine chloride) and melatonin. (16374044)
2006
11
Analysis of the macula with optical coherence tomography after successful surgery for proliferative vitreoretinopathy. (16344435)
2005
12
Interleukin (IL)-6, interleukin (IL)-8 levels and cellular composition of the vitreous humor in proliferative diabetic retinopathy, proliferative vitreoretinopathy, and traumatic proliferative vitreoretinopathy. (16422002)
2005
13
A randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in management of established proliferative vitreoretinopathy. (15582080)
2004
14
Proliferative vitreoretinopathy developed in HLA-B27-associated uveitis. (12928698)
2003
15
Indocyanine green-assisted peeling of the epiretinal membrane in proliferative vitreoretinopathy. (12644944)
2003
16
Outcomes of surgery for retinal detachment associated with proliferative vitreoretinopathy using perfluoro-n-octane: a multicenter study. (12967798)
2003
17
A cost-utility analysis of interventions for severe proliferative vitreoretinopathy. (11860974)
2002
18
The effect of platelet-derived growth factor on the formation of proliferative vitreoretinopathy]. (11955317)
2002
19
Ribozyme to proliferating cell nuclear antigen to treat proliferative vitreoretinopathy. (12356843)
2002
20
Sustained release of cis-hydroxyproline in the treatment of experimental proliferative vitreoretinopathy in rabbits. (12192462)
2002
21
Upregulation of extracellular ATP-induced MA1ller cell responses in a dispase model of proliferative vitreoretinopathy. (11867610)
2002
22
Ultrasound biomicroscopic features of anterior proliferative vitreoretinopathy. (10380025)
1999
23
Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative vitreoretinopathy. (10612518)
1999
24
Substance P in proliferative vitreoretinopathy: the significance of aqueous humor levels for evolution of the disease. (9865620)
1998
25
Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy. (9872531)
1998
26
A prospective study of matrix metalloproteinases in proliferative vitreoretinopathy. (9660504)
1998
27
Growth factors in proliferative vitreoretinopathy. (9613372)
1998
28
Inflammation measurement and immunocharacterization of cell proliferation in an experimental model of proliferative vitreoretinopathy. (9731115)
1998
29
A new model of proliferative vitreoretinopathy. (9761295)
1998
30
Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. Silicone Study report 11. (9076205)
1997
31
Cryopexy in primary rhegmatogenous retinal detachment: a risk factor for postoperative proliferative vitreoretinopathy? (8986445)
1996
32
Proliferative vitreoretinopathy. (7488570)
1995
33
Perfluorocarbon liquid in the management of retinal detachment with proliferative vitreoretinopathy. (7724180)
1995
34
The effect of oral 13-cis-retinoic acid on retinal redetachment after surgical repair in eyes with proliferative vitreoretinopathy. (7891978)
1995
35
Macular changes and fluorescein angiographic findings after repair of proliferative vitreoretinopathy. (7899714)
1994
36
Origin of fibronectin in epiretinal membranes of proliferative vitreoretinopathy and proliferative diabetic retinopathy. (8494861)
1993
37
N,N-dimethyladriamycin for treatment of experimental proliferative vitreoretinopathy: efficacy and toxicity on the rabbit retina. (8500561)
1993
38
Oxytalan fibres in proliferative vitreoretinopathy. (1490137)
1992
39
Lymphocytes, macrophages and HLA-DR expression in vitreal and epiretinal membranes of proliferative vitreoretinopathy. An immunohistochemical study. (1483132)
1992
40
Proliferative vitreoretinopathy in fundus flavimaculatus. (1598966)
1992
41
Proliferative vitreoretinopathy. Lymphocytes in epiretinal membranes. (1407970)
1992
42
Causes of failure after repeat vitreoretinal surgery for recurrent proliferative vitreoretinopathy. (1985484)
1991
43
Retinal microglia: a new cell in idiopathic proliferative vitreoretinopathy? (1915683)
1991
44
Proliferative vitreoretinopathy--is it anything more than wound healing at the wrong place? (2187005)
1990
45
Proliferative vitreoretinopathy membranes. An immunohistochemical study. (2662102)
1989
46
A fluorescein angiographic study on patients with proliferative vitreoretinopathy treated by vitrectomy and intraocular daunomycin. (2793316)
1989
47
Results of silicone oil removal in advanced proliferative vitreoretinopathy. (2665501)
1989
48
The pathophysiology of proliferative vitreoretinopathy. (2851252)
1988
49
Cellular migration, proliferation, and contraction. An in vitro approach to a clinical problem--proliferative vitreoretinopathy. (2874784)
1986
50
Results of conventional vitreous surgery for proliferative vitreoretinopathy. (4073188)
1985

Genetic Variations for Proliferative Vitreoretinopathy

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Expression for genes affiliated with Proliferative Vitreoretinopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proliferative Vitreoretinopathy

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Pathways for genes affiliated with Proliferative Vitreoretinopathy

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
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Compounds for genes affiliated with Proliferative Vitreoretinopathy

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1retinaldehyde4410.7RBP3, GFAP, RLBP1
2cycloheximide4410.7RBP3, ITGAX
3streptozotocin4410.6NUDT6, ADM, GFAP
4forskolin44 49 1112.6IGFBP6, ADM, GFAP, NUDT6, NTF4
5bibn 4096 bs4410.6GPR182, ADM
6n-formylmethionyl-leucylphenylalanine4410.6VTN, GFAP, ITGAX
7lactate4410.5GFAP, ADM, VTN, NUDT6, CA3
8arginine4410.5ADM, VTN, GFAP, NUDT6, NTF4, KLK11
9cysteine4410.5GFAP, KLK11, CA3, GREM1, NUDT6, ADM
10retinoic acid44 2411.5NTF4, RLBP1, RBP3, ITGAX, IGFBP6, NUDT6
11matrigel4410.5VTN, NUDT6, ADM, GFAP
12dbc-amp4410.4NUDT6, GFAP, ADM
13calcium44 49 11 2413.4NTF4, NPY1R, C4B, IGFBP6, NUDT6, GFAP
14glutamate4410.4GFAP, NUDT6, RLBP1, KLK11, VTN, NTF4
1511-cis-retinol44 2411.4RLBP1, RBP3
16tyrosine4410.4ADM, VTN, GFAP, GPR182, NUDT6, NTF4
17phosphatidylinositol4410.3NUDT6, VTN, ADM, NTF4, RLBP1
18acetylcholine44 49 28 11 2414.3NTF4, NUDT6, GFAP, ADM
19dexamethasone44 49 28 1113.0VTN, IGFBP6, GREM1, ADM, GFAP

GO Terms for genes affiliated with Proliferative Vitreoretinopathy

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16Gene Ontology
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Cellular components related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.2KLK11, CCL21, C4B, RBP3, NTF4, IGFBP6
2extracellular spaceGO:0056159.9CCL21, C4B, RBP3, GREM1, IGFBP6, VTN

Biological processes related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.4VTN, C4B
2neuron projection regenerationGO:03110210.4ADM, GFAP
3positive regulation of receptor-mediated endocytosisGO:04826010.3VTN, CCL21
4immune responseGO:00695510.0CCL21, LST1, NCR3, VTN

Products for genes affiliated with Proliferative Vitreoretinopathy

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Sources for Proliferative Vitreoretinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet