MCID: PRL011
MIFTS: 42

Proliferative Vitreoretinopathy malady

Summaries for Proliferative Vitreoretinopathy

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64Wikipedia, 33MalaCards
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Wikipedia:64 Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous... more...

MalaCards: Proliferative Vitreoretinopathy, also known as proliferative vitreo-retinopathy, is related to proliferative diabetic retinopathy and vitreous detachment. An important gene associated with Proliferative Vitreoretinopathy is NTF4 (neurotrophin 4), and among its related pathways are The retinoid cycle in cones (daylight vision) and the visual cycle I (vertebrates). The compounds retinaldehyde and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include retina, small intestine and breast.

Aliases & Classifications for Proliferative Vitreoretinopathy

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

proliferative vitreoretinopathy 8 10 61
proliferative vitreo-retinopathy 61
vitreoretinopathy proliferative 45
retinitis proliferans 8


External Ids:

Disease Ontology8 DOID:9719
MeSH35 D018630

Related Diseases for Proliferative Vitreoretinopathy

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Proliferative Vitreoretinopathy:



Diseases related to proliferative vitreoretinopathy

Clinical Features for Proliferative Vitreoretinopathy

Drugs & Therapeutics for Proliferative Vitreoretinopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Proliferative Vitreoretinopathy

Drug clinical trials:

Search ClinicalTrials for Proliferative Vitreoretinopathy

Search NIH Clinical Center for Proliferative Vitreoretinopathy

Search CenterWatch for Proliferative Vitreoretinopathy

Genetic Tests for Proliferative Vitreoretinopathy

Anatomical Context for Proliferative Vitreoretinopathy

Sources:
33MalaCards
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MalaCards organs/tissues related to Proliferative Vitreoretinopathy:

33
Retina, Small intestine, Breast, Placenta, Monocytes, B cells, Endothelial

Animal Models for Proliferative Vitreoretinopathy or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Proliferative Vitreoretinopathy

Sources:
51PubMed
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Articles related to Proliferative Vitreoretinopathy:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. (24022401)
2014
2
SU9518 inhibits proliferative vitreoretinopathy in fibroblast and genetically modified MA1ller cell-induced rabbit models. (23341018)
2013
3
Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery. (23440808)
2013
4
Attenuated glial reaction in experimental proliferative vitreoretinopathy treated with liposomal doxorubicin. (22491400)
2012
5
A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. (22035642)
2011
6
Patomechanisms in proliferative vitreoretinopathy. (21853955)
2011
7
A strong genetic association between the tumor necrosis factor locus and proliferative vitreoretinopathy: the retina 4 project. (20663564)
2010
8
Alkylphosphocholines: a new approach to inhibit cell proliferation in proliferative vitreoretinopathy. (19494652)
2009
9
Aggregations of retinal pigment epithelial cells on inferior retinal blood vessels, a clinical sign of early proliferative vitreoretinopathy. (19128379)
2008
10
Expression and localisation of BDNF, NT4 and TrkB in proliferative vitreoretinopathy. (18405896)
2008
11
Prevention and control of proliferative vitreoretinopathy: primary retinal detachment surgery using silicone oil as a planned two-stage procedure in high-risk cases. (17277751)
2008
12
Proliferative vitreoretinopathy as a late complication of blunt ocular trauma. (18358999)
2008
13
Vitreous proteomic analysis of proliferative vitreoretinopathy. (18752205)
2008
14
Combined 5-fluorouracil, low-molecular-weight heparin, and silicone oil in the management of complicated retinal detachment with proliferative vitreoretinopathy grade C. (17674917)
2007
15
In vivo models of proliferative vitreoretinopathy. (17401340)
2007
16
Keratinocyte transglutaminase in proliferative vitreoretinopathy. (17065518)
2006
17
Immunoreactive ET-1 in the vitreous humor and epiretinal membranes of patients with proliferative vitreoretinopathy. (16030497)
2005
18
Intravitreal crystalline triamcinolone acetonide as an additional tool in pars plana vitrectomy for complicated proliferative vitreoretinopathy? (14641276)
2003
19
Basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreoretinopathy. (12208248)
2002
20
The effect of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinases, on posttraumatic proliferative vitreoretinopathy. (11114600)
2001
21
Subretinal "napkin-ring" membrane in proliferative vitreoretinopathy. (10980777)
2000
22
Prevention of experimental proliferative vitreoretinopathy with daunomycin and triamcinolone based on the time course of the disease. (10424311)
1999
23
Expression of vitreous cytokines in proliferative vitreoretinopathy: a prospective study. (10067974)
1999
24
Development of a multiple-drug delivery implant for intraocular management of proliferative vitreoretinopathy. (9795083)
1998
25
A new curved vitreous cutter for managing phakic retinal detachment with proliferative vitreoretinopathy. (9847480)
1998
26
C-C chemokines in the vitreous of patients with proliferative vitreoretinopathy and proliferative diabetic retinopathy. (9869464)
1998
27
An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. (9445210)
1998
28
Proliferative vitreoretinopathy: a natural history of the fellow eye. (9593376)
1998
29
Long-term results after scleral buckling surgery in uncomplicated juvenile retinal detachment without proliferative vitreoretinopathy. (9869456)
1998
30
Levels of some cytokines in subretinal fluid in proliferative vitreoretinopathy and rhegmatogenous retinal detachment. (9101198)
1997
31
Antiproliferative effect of mitomycin C on experimental proliferative vitreoretinopathy in rabbits. (9510652)
1997
32
Suppression of experimental proliferative vitreoretinopathy by sustained intraocular delivery of 5-FU. (8537196)
1995
33
Inhibition of experimental proliferative vitreoretinopathy in rabbits by suramin. (8545096)
1995
34
Surgical results for proliferative vitreoretinopathy. (7711473)
1994
35
Anterior proliferative vitreoretinopathy in trauma and complicated retinal detachment. A histopathologic study. (8142875)
1994
36
Laser endoscope in the management of proliferative vitreoretinopathy. (8058285)
1994
37
Five-year results of vitrectomy and silicone oil in patients with proliferative vitreoretinopathy. (8115727)
1993
38
Macrophages in proliferative vitreoretinopathy and proliferative diabetic retinopathy: differentiation of subpopulations. (8280690)
1993
39
Pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment uncomplicated by advanced proliferative vitreoretinopathy. (8494853)
1993
40
Growth factors in vitreous and subretinal fluid cells from patients with proliferative vitreoretinopathy. (8446368)
1993
41
A case-control study of risk factors for proliferative vitreoretinopathy in aphakia. (8230844)
1993
42
Idiopathic proliferative vitreoretinopathy. Activation of microglial cells as the deciding factor]. (1304218)
1992
43
In vitro studies of the contractility of cell types involved in proliferative vitreoretinopathy. (1428714)
1992
44
Vitrectomy with silicone oil or sulfur hexafluoride gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 1. (1596224)
1992
45
Dissection of epiciliary tissue to treat chronic hypotony after surgery for retinal detachment with proliferative vitreoretinopathy. (1925084)
1991
46
Causes of failure after initial vitreoretinal surgery for severe proliferative vitreoretinopathy. (1985496)
1991
47
Evaluation of radiation therapy for experimental proliferative vitreoretinopathy in rabbits. (2265771)
1990
48
Proliferative vitreoretinopathy. Ultrastructural study of 20 retroretinal membranes removed by vitreous surgery. (3231920)
1988
49
Vitrectomy and scleral buckling methods for proliferative vitreoretinopathy. (3174035)
1988
50
Management of anterior and posterior proliferative vitreoretinopathy. XLV. Edward Jackson memorial lecture. (3056014)
1988

Genetic Variations for Proliferative Vitreoretinopathy

Expression for genes affiliated with Proliferative Vitreoretinopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proliferative Vitreoretinopathy

Search GEO for disease gene expression data for Proliferative Vitreoretinopathy.

Pathways for genes affiliated with Proliferative Vitreoretinopathy

Sources:
54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore
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Compounds for genes affiliated with Proliferative Vitreoretinopathy

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1retinaldehyde4510.7RBP3, GFAP, RLBP1
2cycloheximide4510.7RBP3, ITGAX
3streptozotocin4510.6NUDT6, ADM, GFAP
4forskolin45 50 1112.6IGFBP6, ADM, GFAP, NUDT6, NTF4
5bibn 4096 bs4510.6GPR182, ADM
6n-formylmethionyl-leucylphenylalanine4510.6VTN, GFAP, ITGAX
7lactate4510.5GFAP, ADM, VTN, NUDT6, CA3
8arginine4510.5ADM, VTN, GFAP, NUDT6, NTF4, KLK11
9cysteine4510.5GFAP, KLK11, CA3, GREM1, NUDT6, ADM
10retinoic acid45 2411.5NTF4, RLBP1, RBP3, ITGAX, IGFBP6, NUDT6
11matrigel4510.5VTN, NUDT6, ADM, GFAP
12dbc-amp4510.4NUDT6, GFAP, ADM
13calcium45 50 11 2413.4NTF4, NPY1R, C4B, IGFBP6, NUDT6, GFAP
14glutamate4510.4GFAP, NUDT6, RLBP1, KLK11, VTN, NTF4
1511-cis-retinol45 2411.4RLBP1, RBP3
16tyrosine4510.4ADM, VTN, GFAP, GPR182, NUDT6, NTF4
17phosphatidylinositol4510.3NUDT6, VTN, ADM, NTF4, RLBP1
18acetylcholine45 50 29 11 2414.3NTF4, NUDT6, GFAP, ADM
19dexamethasone45 50 29 1113.0VTN, IGFBP6, GREM1, ADM, GFAP

GO Terms for genes affiliated with Proliferative Vitreoretinopathy

Sources:
16Gene Ontology
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Cellular components related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.2CCL21, C4B, RBP3, NTF4, IGFBP6, VTN
2extracellular spaceGO:0056159.9ADM, CCL21, C4B, RBP3, GREM1, IGFBP6

Biological processes related to Proliferative Vitreoretinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.4VTN, C4B
2neuron projection regenerationGO:03110210.4ADM, GFAP
3positive regulation of receptor-mediated endocytosisGO:04826010.3VTN, CCL21
4immune responseGO:00695510.0CCL21, LST1, NCR3, VTN

Products for genes affiliated with Proliferative Vitreoretinopathy

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Sources for Proliferative Vitreoretinopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet