MCID: PRL017
MIFTS: 47

Prolymphocytic Leukemia malady

Summaries for Prolymphocytic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Prolymphocytic leukemia is divided into two types according to the kind of cell involved: B-cell... more...

MalaCards: Prolymphocytic Leukemia, also known as leukemia prolymphocytic, is related to leukemia and t-cell leukemia. An important gene associated with Prolymphocytic Leukemia is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Apoptosis Pathway and PLK3 signaling events. The compounds neocarzinostatin and bpde have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Prolymphocytic Leukemia

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

prolymphocytic leukemia 8 10 60
leukemia prolymphocytic 44


External Ids:

Disease Ontology8 DOID:1039
NCIt39 C3181
MeSH34 D015463

Related Diseases for Prolymphocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Prolymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.9CD5, ETV6, IGKC, NFKB1, ANPEP, CHEK2
2t-cell leukemia31.6ATM, TCL1A, CD7, MTCP1, NFKB1, ZAP70
3chronic lymphocytic leukemia31.1CD52, TCL1A, MS4A1, ZAP70, CD38, CD5
4acute leukemia30.8SMARCB1, CD7, ANPEP, ATM, ETV6
5hodgkin's lymphoma30.4MS4A1, TCL1A, ATM, ZAP70
6ataxia telangiectasia30.3ATM, TP53, TCL1A, CHEK2, MTCP1
7sarcoma30.3SMARCB1, TP53, ANPEP, CHEK2, ETV6
8macroglobulinemia30.1CD5, CD19
9nijmegen breakage syndrome30.1ATM, CHEK2
10myeloid leukemia30.1ANPEP, ETV6, CD38
11breast cancer30.1ATM, CHEK2
12myeloma30.1TCL1A, ANPEP, CD38, CD19, IGKC
13acute lymphocytic leukemia30.1CD5, CD38, CD19, ETV6, CD7, ZAP70
14b cell prolymphocytic leukemia10.5
15hairy cell leukemia10.5
16t-cell prolymphocytic leukemia10.4
17graft versus host disease10.2
18splenic manifestation of prolymphocytic leukemia10.2
19acute t cell leukemia10.2
20central nervous system leukemia10.2
21mantle cell lymphoma10.2
22diffuse large b-cell lymphoma10.2
23t-cell large granular lymphocyte leukemia10.2
24meningitis10.2
25t-cell prolymphocytic leukemia, somatic10.2
26acute liver failure10.1
27richter's syndrome10.1
28adult t-cell leukemia10.1
29leukostasis10.1
30lymphosarcoma10.1
31adult syndrome10.1
32adult lymphoma10.1
33exanthem10.1
34gingivitis10.1
35malignant mesothelioma10.1
36panuveitis10.1
37polyradiculoneuropathy10.1
38rhabdomyosarcoma10.1
39t cell deficiency10.1
40thrombocytopenia10.1
41vasculitis10.1
42arthritis10.0ANPEP
43hepatitis10.0ANPEP
44hepatitis c10.0HLA-S
45amyloidosis10.0IGKC
46laryngeal squamous cell carcinoma10.0TP53
47deficiency anemia10.0CD5, CD19
48meningioma10.0SMARCB1
49severe combined immunodeficiency10.0CD38, ZAP70
50fanconi's anemia10.0ATM

Graphical network of the top 20 diseases related to Prolymphocytic Leukemia:



Diseases related to prolymphocytic leukemia

Clinical Features for Prolymphocytic Leukemia

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Drugs & Therapeutics for Prolymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Prolymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Prolymphocytic Leukemia

Search NIH Clinical Center for Prolymphocytic Leukemia

Search CenterWatch for Prolymphocytic Leukemia

Genetic Tests for Prolymphocytic Leukemia

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Anatomical Context for Prolymphocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Prolymphocytic Leukemia:

32
T cells, B cells, Bone, Bone marrow, Skin, Heart, Spleen, Eye, Breast, Myeloid, Lymph node, Liver, Endothelial, Small intestine

Animal Models for Prolymphocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Prolymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3CHEK2, ETV6, CD19, CDKN1B, SMARCB1
2MP:00028739.3TP53, CD52, CD19, CD5, ETV6, NFKB1
3MP:00053978.1IGKC, NFKB1, ANPEP, CHEK2, ATM, ZAP70
4MP:00053848.1ETV6, IGKC, NFKB1, CHEK2, ATM, ZAP70
5MP:00053878.0TP53, ZAP70, ATM, CHEK2, ANPEP, NFKB1

Publications for Prolymphocytic Leukemia

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50PubMed
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Articles related to Prolymphocytic Leukemia:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Reply to "A combination treatment approach and cord blood stem cell transplant for blastic plasmacytoid dendritic cell neoplasm" and to "A low-grade B-cell lymphoma with prolymphocytic/paraimmunoblastic proliferation and IRF4 rearrangement" dendritic cell leukemia. (23449597)
2013
2
Cutaneous presentation of T-cell prolymphocytic leukemia. (23513557)
2013
3
Generalized purpuric drug exanthem with hemorrhagic plaques following bendamustine chemotherapy in a patient with B-prolymphocytic leukemia. (22290027)
2012
4
Pediatric T-cell prolymphocytic leukemia with an isolated 12(p13) deletion and aberrant CD117 expression. (23211022)
2012
5
Cost-effectiveness of alemtuzumab for T-cell prolymphocytic leukemia. (22980700)
2012
6
T-cell prolymphocytic leukemia with cutaneous involvement as the presenting feature. (22615522)
2012
7
B- and T-cell prolymphocytic leukemia: antibody approaches. (23233647)
2012
8
TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients. (22189846)
2012
9
Case Study Interpretation--Houston: Case 4. T-cell prolymphocytic leukemia. (21638771)
2011
10
Guillain-BarrAc syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: a case report and review of the literature. (20362332)
2010
11
B-cell prolymphocytic leukemia and chronic lymphocytic leukemia have distinctive gene expression signatures. (19641528)
2009
12
T-cell prolymphocytic leukemia: a report of two cases with review of literature. (23100959)
2008
13
Successful treatment of T-cell prolymphocytic leukemia with full-intensity conditioning followed by matched unrelated donor allogeneic stem cell transplantation. (18185486)
2007
14
Complete response to alemtuzumab in a patient with B prolymphocytic leukemia. (17160995)
2007
15
T-cell prolymphocytic leukemia: an aggressive T cell malignancy with frequent cutaneous tropism. (16908353)
2006
16
T-cell prolymphocytic leukemia involving extramedullary sites. (15716243)
2005
17
Mismatched unrelated cord blood transplantation in a patient with T-cell prolymphocytic leukemia. (15690068)
2005
18
T cell prolymphocytic leukemia with new chromosome rearrangements. (15034240)
2004
19
Successful treatment of B-cell prolymphocytic leukemia with monoclonal anti-CD20 antibody. (15060751)
2004
20
Allogeneic bone marrow transplantation in a patient with T-prolymphocytic leukemia with small-intestinal involvement. (14663643)
2003
21
Alemtuzumab in relapsed or refractory chronic lymphocytic leukemia and prolymphocytic leukemia. (12148879)
2002
22
Are activation markers (CD25, CD38 and CD103) predictive of sensitivity to purine analogues in patients with T-cell prolymphocytic leukemia and other lymphoproliferative disorders? (12613520)
2002
23
Skin and gingival lesions in a young woman with B-prolymphocytic leukemia (B-PLL). (11718228)
2001
24
Improvement of quality of life after splenectomy in an HTLV-I carrier with T-cell prolymphocytic leukemia. (10609799)
1999
25
T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23). (10347553)
1999
26
Leukemic pleural effusion in B-cell prolymphocytic leukemia. (9924927)
1998
27
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. (9519406)
1998
28
Inactivation of the ATM gene in T-cell prolymphocytic leukemias. (9573030)
1998
29
Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia. (9657733)
1998
30
5' region and exon 7 mutations of the TP53 gene in two cases of B-cell prolymphocytic leukemia. (9844609)
1998
31
Perforin-positive leukemic cell infiltration in the aortic tissue of a patient with T-cell prolymphocytic leukemia. (8971584)
1996
32
Perforin-positive leukemic cell infiltration in the heart of a patient with T-cell prolymphocytic leukemia. (8563121)
1995
33
ProMACE day 1/MOPP day 8 chemotherapy for prolymphocytic leukemia: a case report of prolonged survival. (8192154)
1994
34
Effects of lymph node stromal cells on the differentiation of a cell line established from an atypical prolymphocytic leukemia with phenotypes of both chronic lymphocytic and hairy cell leukemias. (7820053)
1994
35
Effectiveness of fludarabine in end-stage prolymphocytic leukemia. (8057685)
1994
36
Prolymphocytic leukemia: a very satisfactory response to treatment with recombinant interferon alpha. (1398302)
1992
37
Rapid response of B-cell prolymphocytic leukemia to 2-chlorodeoxyadenosine. (1357112)
1992
38
Clinical and laboratory features of 78 cases of T-prolymphocytic leukemia. (1742486)
1991
39
Differential response of malignant human B-cells to anti-IgM immunoglobulin (anti-mu) and B-cell growth factor: unique direct cytotoxicity of anti-mu on prolymphocytic leukemia cells. (2119832)
1990
40
Prolymphocytic leukemia. (2182602)
1990
41
B prolymphocytic leukemia cell lines: phenotype and response to B cell differentiation factor. (3259689)
1988
42
T-cell prolymphocytic leukemia (T-PLL) with unique surface phenotype. (3103723)
1987
43
Functional and phenotypic analysis of a T cell prolymphocytic leukemia. (3159942)
1985
44
Functional diversity within the suppressor phenotype as defined by monoclonal antibody in T-cell prolymphocytic leukemia. (6202139)
1984
45
Prolymphocytic leukemia with IgM hypogammaglobulinemia. (6603786)
1983
46
Possible specific chromosome change in prolymphocytic leukemia. (6882921)
1983
47
T cell prolymphocytic leukemia. 2 cases having a postthymic helper phenotype with complement receptors and 14q+ chromosome abnormality. (6223478)
1983
48
Prolymphocytic leukemia: flow microfluorometric, immunologic, and cytogenetic observations. (7015848)
1980
49
Alkaline phosphatase and tartrate resistant acid phosphatase activity in cells of prolymphocytic leukemia. (642404)
1978
50
Prolymphocytic leukemia with T cell properties and tartrate resistant acid phosphatase. (305394)
1977

Genetic Variations for Prolymphocytic Leukemia

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Expression for genes affiliated with Prolymphocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prolymphocytic Leukemia

Search GEO for disease gene expression data for Prolymphocytic Leukemia.

Pathways for genes affiliated with Prolymphocytic Leukemia

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Sources:
59Tocris Bioscience, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 49PharmGKB
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Pathways related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3ATM
210.2CHEK2, TP53
3
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10.2ATM, CHEK2
4
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
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10.0TP53, CHEK2, ATM
510.0ATM, CHEK2, TP53
610.0TP53, CHEK2, ATM
710.0TP53, CHEK2, ATM
8
DNA damage Role of Brca1 and Brca2 in DNA repair
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10.0ATM, CHEK2, TP53
9
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10.0ATM, CHEK2, TP53
10
Hide members
10.0TP53, CDKN1B, ATM
1110.0ATM, CDKN1B, TP53
12
Hide members
10.0CHEK2, NFKB1, TP53
1310.0NFKB1, ATM, ZAP70
14
Transcription P53 signaling pathway
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10.0TP53, NFKB1, ATM
15
Hide members
10.0TP53, CDKN1B, NFKB1
16
Hide members
10.0TP53, CDKN1B, NFKB1
17
Hide members
10.0TP53, CDKN1B, NFKB1
1810.0TP53, CDKN1B, NFKB1
19
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.0NFKB1, CDKN1B, TP53
2010.0CDKN1B, NFKB1, ATM
21
Immune response NFAT in immune response
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10.0IGKC, NFKB1, ZAP70
22
Hide members
9.8ATM, CHEK2, CDKN1B, TP53
23
Hide members
9.8ATM, CHEK2, CDKN1B, TP53
249.8TP53, SMARCB1, CHEK2, ATM
259.8ATM, CHEK2, NFKB1, TP53
269.8ATM, CHEK2, NFKB1, TP53
279.8ATM, CHEK2, NFKB1, TP53
28
Hide members
9.8ZAP70, NFKB1, IGKC, CD19
299.8TP53, CDKN1B, NFKB1, ATM
30
Hide members
9.8ATM, NFKB1, CDKN1B, TP53
31
Hide members
9.8ATM, NFKB1, CDKN1B, TP53
32
Hide members
9.8NFKB1, IGKC, CD19, CDKN1B
33
Hide members
9.8NFKB1, IGKC, CD19, CDKN1B
349.7NFKB1, CD19, CD38, CDKN1B, TP53
35
Hide members
9.7TP53, NFKB1, CHEK2, ATM, ZAP70
369.7TP53, CDKN1B, NFKB1, CHEK2, ATM
379.6ATM, NFKB1, ETV6, CDKN1B, TP53
389.5MS4A1, CD7, CD38, CD19, CD5, ANPEP
39
Hide members
9.5TP53, CDKN1B, NFKB1, CHEK2, ATM, ZAP70
409.4MTCP1, NFKB1, CD19, CDKN1B, TCL1A, TP53

Compounds for genes affiliated with Prolymphocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1neocarzinostatin4410.4ATM, CHEK2
2bpde4410.3TP53, CHEK2, ATM
3ricin4410.2CD5, CD19
4aphidicolin4410.2ATM, CHEK2, CDKN1B, TP53
5gemcitabine44 49 1112.2TP53, CDKN1B, CHEK2
6rituximab44 49 1112.2ZAP70, CD38, CD52, MS4A1
7camptothecin44 59 1112.1TP53, CDKN1B, CHEK2, ATM
8hydroxyurea44 49 1112.1ATM, CHEK2, TP53
9n acetylcysteine4410.1ATM, CHEK2, CDKN1B, TP53
10cyclophosphamide44 49 1112.0HLA-S, ZAP70, CDKN1B, MS4A1, TP53
11etoposide44 49 59 1113.0ATM, CHEK2, NFKB1, CDKN1B, TP53
12cytarabine44 49 1111.9TP53, CDKN1B, ATM
13paraffin449.9ATM, ANPEP, CD5, CDKN1B, MS4A1, TP53
14fludarabine44 1110.9TP53, MS4A1, CD52, CDKN1B, CD38, ZAP70
15doxorubicin44 49 1111.9ATM, CHEK2, ANPEP, CD19, CDKN1B, TP53
16phosphatidylinositol449.8ZAP70, ATM, CHEK2, CD19, CD38, CDKN1B
17serine449.8TCL1A, CDKN1B, ANPEP, CHEK2
18atp44 2810.7ZAP70, ATM, CHEK2, ANPEP, CD38, CDKN1B
19threonine449.7ZAP70, ATM, CHEK2, ANPEP, CDKN1B, TCL1A
20oligonucleotide449.7TP53, CDKN1B, ANPEP, CHEK2, ZAP70
21retinoic acid44 2410.6CHEK2, ANPEP, ETV6, CD38, CDKN1B, TP53
22wortmannin449.5ATM, CHEK2, ANPEP, CDKN1B
23tyrosine449.3ZAP70, ATM, CHEK2, ANPEP, ETV6, CD5

GO Terms for genes affiliated with Prolymphocytic Leukemia

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16Gene Ontology
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Cellular components related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6ANPEP, CD5, CD19, MS4A1
2nucleoplasmGO:0056549.5ATM, CHEK2, NFKB1, CDKN1B, SMARCB1, TP53

Biological processes related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.2CHEK2, ATM
2replicative senescenceGO:09039910.2TP53, CHEK2, ATM
3double-strand break repairGO:00630210.0TP53, CHEK2, ATM, BRCC3
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.0ATM, CDKN1B, TP53
5Fc-epsilon receptor signaling pathwayGO:0380959.9NFKB1, IGKC, CD19, CDKN1B
6mitotic cell cycle arrestGO:0718509.9CDKN1B, TP53
7immune responseGO:0069559.8MS4A1, CD7, IGKC, ZAP70
8negative regulation of apoptotic processGO:0430669.6TP53, CDKN1B, CD38, NFKB1, ATM

Products for genes affiliated with Prolymphocytic Leukemia

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  • Antibodies
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Sources for Prolymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet