MCID: PRL017
MIFTS: 47

Prolymphocytic Leukemia malady

Summaries for Prolymphocytic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Prolymphocytic leukemia is divided into two types according to the kind of cell involved: B-cell... more...

MalaCards: Prolymphocytic Leukemia, also known as leukemia prolymphocytic, is related to leukemia and t-cell leukemia. An important gene associated with Prolymphocytic Leukemia is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Apoptosis Pathway and PLK3 signaling events. The compounds neocarzinostatin and bpde have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone marrow, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Prolymphocytic Leukemia

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

prolymphocytic leukemia 8 10 60
leukemia prolymphocytic 44


External Ids:

Disease Ontology8 DOID:1039
NCIt39 C3181
MeSH34 D015463

Related Diseases for Prolymphocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Prolymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.9CD5, ETV6, IGKC, NFKB1, ANPEP, CHEK2
2t-cell leukemia31.6ATM, TCL1A, CD7, MTCP1, NFKB1, ZAP70
3chronic lymphocytic leukemia31.1CD52, TCL1A, MS4A1, ZAP70, CD38, CD5
4acute leukemia30.8SMARCB1, CD7, ANPEP, ATM, ETV6
5hodgkin's lymphoma30.4MS4A1, TCL1A, ATM, ZAP70
6ataxia telangiectasia30.3ATM, TP53, TCL1A, CHEK2, MTCP1
7sarcoma30.3SMARCB1, TP53, ANPEP, CHEK2, ETV6
8macroglobulinemia30.1CD5, CD19
9nijmegen breakage syndrome30.1ATM, CHEK2
10myeloid leukemia30.1ANPEP, ETV6, CD38
11breast cancer30.1ATM, CHEK2
12myeloma30.1TCL1A, ANPEP, CD38, CD19, IGKC
13acute lymphocytic leukemia30.1CD5, CD38, CD19, ETV6, CD7, ZAP70
14b cell prolymphocytic leukemia10.5
15hairy cell leukemia10.5
16t-cell prolymphocytic leukemia10.4
17graft versus host disease10.2
18splenic manifestation of prolymphocytic leukemia10.2
19acute t cell leukemia10.2
20central nervous system leukemia10.2
21mantle cell lymphoma10.2
22diffuse large b-cell lymphoma10.2
23t-cell large granular lymphocyte leukemia10.2
24meningitis10.2
25t-cell prolymphocytic leukemia, somatic10.2
26acute liver failure10.1
27richter's syndrome10.1
28adult t-cell leukemia10.1
29leukostasis10.1
30lymphosarcoma10.1
31adult syndrome10.1
32adult lymphoma10.1
33exanthem10.1
34gingivitis10.1
35malignant mesothelioma10.1
36panuveitis10.1
37polyradiculoneuropathy10.1
38rhabdomyosarcoma10.1
39t cell deficiency10.1
40thrombocytopenia10.1
41vasculitis10.1
42arthritis10.0ANPEP
43hepatitis10.0ANPEP
44hepatitis c10.0HLA-S
45amyloidosis10.0IGKC
46laryngeal squamous cell carcinoma10.0TP53
47deficiency anemia10.0CD5, CD19
48meningioma10.0SMARCB1
49severe combined immunodeficiency10.0CD38, ZAP70
50fanconi's anemia10.0ATM

Graphical network of the top 20 diseases related to Prolymphocytic Leukemia:



Diseases related to prolymphocytic leukemia

Clinical Features for Prolymphocytic Leukemia

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Drugs & Therapeutics for Prolymphocytic Leukemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Prolymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Prolymphocytic Leukemia

Search NIH Clinical Center for Prolymphocytic Leukemia

Search CenterWatch for Prolymphocytic Leukemia

Genetic Tests for Prolymphocytic Leukemia

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Anatomical Context for Prolymphocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Prolymphocytic Leukemia:

32
T cells, B cells, Bone marrow, Bone, Skin, Spleen, Heart, Myeloid, Breast, Liver, Lymph node, Eye, Endothelial, Small intestine

Animal Models for Prolymphocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Prolymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3CHEK2, ETV6, CD19, CDKN1B, SMARCB1
2MP:00028739.3TP53, CD52, CD19, CD5, ETV6, NFKB1
3MP:00053978.1IGKC, NFKB1, ANPEP, CHEK2, ATM, ZAP70
4MP:00053848.1ETV6, IGKC, NFKB1, CHEK2, ATM, ZAP70
5MP:00053878.0TP53, ZAP70, ATM, CHEK2, ANPEP, NFKB1

Publications for Prolymphocytic Leukemia

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50PubMed
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Articles related to Prolymphocytic Leukemia:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Sequential chemoimmunotherapy of fludarabine, mitoxantrone, and cyclophosphamide induction followed by alemtuzumab consolidation is effective in T-cell prolymphocytic leukemia. (23512246)
2013
2
T-cell prolymphocytic leukemia. (23382603)
2013
3
Cerebriform variant type of T cell prolymphocytic leukemia with complex karyotype including an additional segment at 1p36.1. (23054642)
2012
4
A Comprehensive Update on Molecular and Cytogenetic Abnormalities in T-cell Prolymphocytic Leukemia (T-pll). (23183331)
2012
5
Epstein-Barr virus-negative classical Hodgkin's lymphoma in a patient with T-cell prolymphocytic leukemia treated with fludarabine. (22706535)
2012
6
Allogeneic hematopoietic cell transplant for prolymphocytic leukemia. (19961946)
2010
7
De novo translocation involving two chromosomes in adult prolymphocytic leukemia--a rare case. (20943268)
2010
8
The first case of de novo B-cell prolymphocytic leukemia with central nervous system involvement: description of an unreported complication. (18929411)
2009
9
Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia. (18073348)
2008
10
Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia. (17898784)
2007
11
Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia. (16997373)
2007
12
Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32). (17713554)
2007
13
Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation. (16541139)
2006
14
Small cell variant of T-cell prolymphocytic leukemia exhibiting suppressor phenotype. (16966296)
2006
15
Allogeneic stem cell transplantation after reduced-intensity conditioning in a patient with T-cell prolymphocytic leukemia: graft-versus-tumor effect and long-term remission. (16474410)
2006
16
An indolent case of T-prolymphocytic leukemia with t(3;22)(q21;q11.2) and elevated serum beta2-microglobulin. (16119992)
2005
17
T- cell prolymphocytic leukemia - a rare case. (16141512)
2005
18
T-cell prolymphocytic leukemia with autoimmune manifestations in Nijmegen breakage syndrome. (12845481)
2003
19
Complex karyotype in one patient with small cell variant of T-prolymphocytic leukemia. Analysis by G-banding and comparative genomic hybridization. (11255284)
2001
20
Allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in primary refractory prolymphocytic leukemia: graft-versus-leukemia effect without graft-versus-host disease. (11803359)
2001
21
Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation. (11168523)
2001
22
Concurrent Hodgkin's disease (mixed cellularity type) and T-cell chronic lymphocytic leukemia/prolymphocytic leukemia. (11372737)
2001
23
Recurrent molecular deletion of the 12p13 region, centromeric to ETV6/TEL, in T-cell prolymphocytic leukemia. (11920168)
2000
24
A brief intensive chemotherapy in T-prolymphocytic leukemia. (10756378)
2000
25
Richter's syndrome in a patient with B prolymphocytic leukemia. (10329926)
1999
26
The human T-cell lymphotropic viruses types I/II are not involved in T prolymphocytic leukemia and large granular lymphocytic leukemia. (9264385)
1997
27
Atypical prolymphocytic variant of hairy-cell leukemia: case report and review of the literature. (8892738)
1996
28
Clinical and hematologic response of chronic lymphocytic and prolymphocytic leukemia persisting after allogeneic bone marrow transplantation with the onset of acute graft-versus-host disease: possible role of graft-versus-leukemia. (8704689)
1996
29
B-cell prolymphocytic leukemia expressing discordant myeloid-associated antigens in simultaneous specimens from bone marrow and peripheral blood. (8556956)
1995
30
Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T-prolymphocytic leukemia and T-cell leukemias in patients with ataxia telangiectasia. (1913594)
1991
31
Bone marrow histological patterns in B-cell and T-cell prolymphocytic leukemia. (2777734)
1989
32
Splenic irradiation as primary therapy for prolymphocytic leukemia. (2916562)
1989
33
Leukostasis: a phenomenon of prolymphocytic leukemia. (2757011)
1989
34
Analysis of T-cell-derived factors with the use of B-prolymphocytic leukemia cells. (3257174)
1988
35
Cytogenetic studies in chronic lymphocytic leukemia, prolymphocytic leukemia and hairy cell leukemia: a progress report. (3222149)
1988
36
Fulminant leukemic polyradiculoneuropathy in a case of B-cell prolymphocytic leukemia. A clinicopathologic report. (3040217)
1987
37
Auer rod-like inclusions in prolymphocytic leukemia. (3037836)
1987
38
Acute tumor lysis syndrome in prolymphocytic leukemia. (3468888)
1987
39
Chronic lymphocytic leukemia and prolymphocytic leukemia: a clinicopathological reappraisal. (3476167)
1987
40
Recurrent chromosome changes at 3p21 in Epstein-Barr virus-transformed cells derived from human prolymphocytic leukemia. (3019524)
1986
41
Prolymphocytic leukemia--a case report. (3463667)
1986
42
Induction of features characteristic of hairy cell leukemia in chronic lymphocytic leukemia and prolymphocytic leukemia cells. (3456270)
1986
43
B-prolymphocytic leukemia cells that form rosettes with sheep red blood cells through monoclonal surface immunoglobulin. (3877461)
1985
44
Prolymphocytic leukemia: histologic findings in atypical cases. (6592135)
1984
45
Cytogenetic studies in a case of T-cell prolymphocytic leukemia. (6609763)
1984
46
Chromosome change in prolymphocytic leukemia. (6585237)
1984
47
Treatment of prolymphocytic leukemia. (6956431)
1982
48
Immunologic characterization and ultrastructural correlations for 125 cases of B- and T-cell leukemias: studies of chronic and acute lymphocytic, prolymphocytic, lymphosarcoma cell and hairy cell leukemia, SAczary's syndrome, and other lymphoid leukemias. (6975649)
1981
49
B-lineage prolymphocytic leukemia as a distinct clinicopathologic entity. (6929655)
1980
50
Evidence for monoclonal proliferation in prolymphocytic leukemia of T-cell orgin. A cytogenetic and Quantitative immunoautoradiographic analysis. (304367)
1977

Genetic Variations for Prolymphocytic Leukemia

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Expression for genes affiliated with Prolymphocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prolymphocytic Leukemia

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Pathways for genes affiliated with Prolymphocytic Leukemia

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Sources:
59Tocris Bioscience, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 49PharmGKB
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Pathways related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3ATM
210.2CHEK2, TP53
3
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10.2ATM, CHEK2
4
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
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10.0TP53, CHEK2, ATM
510.0ATM, CHEK2, TP53
610.0TP53, CHEK2, ATM
710.0TP53, CHEK2, ATM
8
DNA damage Role of Brca1 and Brca2 in DNA repair
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10.0ATM, CHEK2, TP53
9
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10.0ATM, CHEK2, TP53
10
Hide members
10.0TP53, CDKN1B, ATM
1110.0ATM, CDKN1B, TP53
12
Hide members
10.0CHEK2, NFKB1, TP53
1310.0NFKB1, ATM, ZAP70
14
Transcription P53 signaling pathway
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10.0TP53, NFKB1, ATM
15
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10.0TP53, CDKN1B, NFKB1
16
Hide members
10.0TP53, CDKN1B, NFKB1
17
Hide members
10.0TP53, CDKN1B, NFKB1
1810.0TP53, CDKN1B, NFKB1
19
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.0NFKB1, CDKN1B, TP53
2010.0CDKN1B, NFKB1, ATM
21
Immune response NFAT in immune response
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10.0IGKC, NFKB1, ZAP70
22
Hide members
9.8ATM, CHEK2, CDKN1B, TP53
23
Hide members
9.8ATM, CHEK2, CDKN1B, TP53
249.8TP53, SMARCB1, CHEK2, ATM
259.8ATM, CHEK2, NFKB1, TP53
269.8ATM, CHEK2, NFKB1, TP53
279.8ATM, CHEK2, NFKB1, TP53
28
Hide members
9.8ZAP70, NFKB1, IGKC, CD19
299.8TP53, CDKN1B, NFKB1, ATM
30
Hide members
9.8ATM, NFKB1, CDKN1B, TP53
31
Hide members
9.8ATM, NFKB1, CDKN1B, TP53
32
Hide members
9.8NFKB1, IGKC, CD19, CDKN1B
33
Hide members
9.8NFKB1, IGKC, CD19, CDKN1B
349.7NFKB1, CD19, CD38, CDKN1B, TP53
35
Hide members
9.7TP53, NFKB1, CHEK2, ATM, ZAP70
369.7TP53, CDKN1B, NFKB1, CHEK2, ATM
379.6ATM, NFKB1, ETV6, CDKN1B, TP53
389.5MS4A1, CD7, CD38, CD19, CD5, ANPEP
39
Hide members
9.5TP53, CDKN1B, NFKB1, CHEK2, ATM, ZAP70
409.4MTCP1, NFKB1, CD19, CDKN1B, TCL1A, TP53

Compounds for genes affiliated with Prolymphocytic Leukemia

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1neocarzinostatin4410.4ATM, CHEK2
2bpde4410.3TP53, CHEK2, ATM
3ricin4410.2CD5, CD19
4aphidicolin4410.2ATM, CHEK2, CDKN1B, TP53
5gemcitabine44 49 1112.2TP53, CDKN1B, CHEK2
6rituximab44 49 1112.2ZAP70, CD38, CD52, MS4A1
7camptothecin44 59 1112.1TP53, CDKN1B, CHEK2, ATM
8hydroxyurea44 49 1112.1ATM, CHEK2, TP53
9n acetylcysteine4410.1ATM, CHEK2, CDKN1B, TP53
10cyclophosphamide44 49 1112.0HLA-S, ZAP70, CDKN1B, MS4A1, TP53
11etoposide44 49 59 1113.0ATM, CHEK2, NFKB1, CDKN1B, TP53
12cytarabine44 49 1111.9TP53, CDKN1B, ATM
13paraffin449.9ATM, ANPEP, CD5, CDKN1B, MS4A1, TP53
14fludarabine44 1110.9TP53, MS4A1, CD52, CDKN1B, CD38, ZAP70
15doxorubicin44 49 1111.9ATM, CHEK2, ANPEP, CD19, CDKN1B, TP53
16phosphatidylinositol449.8ZAP70, ATM, CHEK2, CD19, CD38, CDKN1B
17serine449.8TCL1A, CDKN1B, ANPEP, CHEK2
18atp44 2810.7ZAP70, ATM, CHEK2, ANPEP, CD38, CDKN1B
19threonine449.7ZAP70, ATM, CHEK2, ANPEP, CDKN1B, TCL1A
20oligonucleotide449.7TP53, CDKN1B, ANPEP, CHEK2, ZAP70
21retinoic acid44 2410.6CHEK2, ANPEP, ETV6, CD38, CDKN1B, TP53
22wortmannin449.5ATM, CHEK2, ANPEP, CDKN1B
23tyrosine449.3ZAP70, ATM, CHEK2, ANPEP, ETV6, CD5

GO Terms for genes affiliated with Prolymphocytic Leukemia

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16Gene Ontology
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Cellular components related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6MS4A1, CD19, CD5, ANPEP
2nucleoplasmGO:0056549.5CHEK2, NFKB1, CDKN1B, SMARCB1, TP53, ATM

Biological processes related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.2CHEK2, ATM
2replicative senescenceGO:09039910.2TP53, CHEK2, ATM
3double-strand break repairGO:00630210.0TP53, CHEK2, ATM, BRCC3
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.0ATM, CDKN1B, TP53
5Fc-epsilon receptor signaling pathwayGO:0380959.9NFKB1, IGKC, CD19, CDKN1B
6mitotic cell cycle arrestGO:0718509.9CDKN1B, TP53
7immune responseGO:0069559.8MS4A1, CD7, IGKC, ZAP70
8negative regulation of apoptotic processGO:0430669.6TP53, CDKN1B, CD38, NFKB1, ATM

Products for genes affiliated with Prolymphocytic Leukemia

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Sources for Prolymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet