MCID: PRL017
MIFTS: 44

Prolymphocytic Leukemia malady

Cancer diseases category
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Summaries for Prolymphocytic Leukemia

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Wikipedia:65 Prolymphocytic leukemia is divided into two types according to the kind of cell involved: B-cell... more...

MalaCards based summary: Prolymphocytic Leukemia, also known as leukemia prolymphocytic, is related to leukemia and chronic lymphocytic leukemia. An important gene associated with Prolymphocytic Leukemia is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Epstein-Barr virus infection and B Cell Receptor Signaling Pathway. The compounds ricin and paraffin have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone marrow, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Prolymphocytic Leukemia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Prolymphocytic Leukemia, Aliases & Descriptions:

Name: Prolymphocytic Leukemia 8 10 62
 
Leukemia Prolymphocytic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:1039
NCIt39 C3181
MeSH34 D015463

Related Diseases for Prolymphocytic Leukemia

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Diseases related to Prolymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0CD19, CD38, CD5, ATM, ZAP70
2chronic lymphocytic leukemia30.9MS4A1, CD5, ZAP70
3macroglobulinemia30.5CD5, CD19
4hodgkin's lymphoma30.3ATM, ZAP70, MS4A1
5t-cell leukemia30.3ZAP70, ATM
6b-cell lymphomas29.6MS4A1, ZAP70, ATM, CD19, CD5
7t-cell prolymphocytic leukemia11.2
8b cell prolymphocytic leukemia10.9
9hairy cell leukemia10.5
10hematopoietic stem cell transplantation10.4
11mantle cell lymphoma10.4
12splenic manifestation of prolymphocytic leukemia10.4
13large granular lymphocyte leukemia10.4
14ataxia telangiectasia10.3
15diffuse large b-cell lymphoma10.3
16graft versus host disease10.3
17t-cell large granular lymphocyte leukemia10.3
18meningitis10.3
19sarcoma10.3
20ataxia10.3
21t-cell prolymphocytic leukemia, somatic10.3
22acute leukemia10.1
23acute liver failure10.1
24adult t-cell leukemia10.1
25thrombocytopenia10.1
26nijmegen breakage syndrome10.1
27richter's syndrome10.1
28leukostasis10.1
29hcl-v10.1
30hypercalcemia10.1
31lymphosarcoma10.1
32anterior scleritis10.1
33breast cancer10.1
34exanthem10.1
35gingivitis10.1
36malignant mesothelioma10.1
37myeloma10.1
38panuveitis10.1
39polyradiculoneuropathy10.1
40rhabdomyosarcoma10.1
41scleritis10.1
42thyroiditis10.1
43vasculitis10.1
44acute graft versus host disease10.1
45cold agglutinin disease10.1
46endotheliitis10.1
47agammaglobulinemia10.1CD19, CD38
48hypersensitivity reaction type ii disease10.1CD5, CD19
49macroglobulinemia, waldenstrom, somatic10.0MS4A1, ZAP70
50deficiency anemia10.0CD5, CD19

Graphical network of the top 20 diseases related to Prolymphocytic Leukemia:



Diseases related to prolymphocytic leukemia

Symptoms for Prolymphocytic Leukemia

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Drugs & Therapeutics for Prolymphocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Prolymphocytic Leukemia

Search NIH Clinical Center for Prolymphocytic Leukemia

Genetic Tests for Prolymphocytic Leukemia

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Anatomical Context for Prolymphocytic Leukemia

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MalaCards organs/tissues related to Prolymphocytic Leukemia:

32
T cells, B cells, Bone marrow, Bone, Skin, Spleen, Heart, Eye, Lymph node, Brain, Liver, Thyroid, Breast, Myeloid, Endothelial, Small intestine

Animal Models for Prolymphocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Prolymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1ATM, MS4A1, ZAP70, CD5, CD19, CD38
2MP:00053976.8ATM, MS4A1, ZAP70, CD5, CD19, CD38

Publications for Prolymphocytic Leukemia

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Articles related to Prolymphocytic Leukemia:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
Aberrations of MYC are a common event in B-cell prolymphocytic leukemia. (25125625)
2014
2
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. (25238936)
2014
3
Immunophenotypic characterization of T-cell prolymphocytic leukemia. (24124154)
2013
4
Smudge cells following treatment with pentostatin in a patient with B-cell prolymphocytic leukemia. (24049774)
2013
5
Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia. (24048415)
2013
6
T-cell prolymphocytic leukemia in Japan: is it a variant? (22527853)
2012
7
Generalized purpuric drug exanthem with hemorrhagic plaques following bendamustine chemotherapy in a patient with B-prolymphocytic leukemia. (22290027)
2012
8
Guillain-BarrAc syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: a case report and review of the literature. (20362332)
2010
9
The evolving management of a rare lymphoproliferative disorder-T-cell prolymphocytic leukemia. (19714590)
2009
10
Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition. (19480937)
2009
11
Rhodococcus equi infection after alemtuzumab therapy for T-cell prolymphocytic leukemia. (18258054)
2007
12
Mature T-cell leukemias including T-prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and SAczary syndrome. (17369126)
2007
13
Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia. (17898784)
2007
14
Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia. (16997373)
2007
15
IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL). (16642047)
2006
16
T-cell prolymphocytic leukemia involving extramedullary sites. (15716243)
2005
17
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
18
An indolent case of T-prolymphocytic leukemia with t(3;22)(q21;q11.2) and elevated serum beta2-microglobulin. (16119992)
2005
19
T- cell prolymphocytic leukemia - a rare case. (16141512)
2005
20
Development of malignant mesothelioma during treatment for prolymphocytic leukemia: is asbestos or simian virus 40 a link? (15816607)
2005
21
Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia. (15066324)
2004
22
Complex karyotype in one patient with small cell variant of T-prolymphocytic leukemia. Analysis by G-banding and comparative genomic hybridization. (11255284)
2001
23
Application of cross-species color banding (RxFISH) in the study of T-prolymphocytic leukemia. (10870117)
2000
24
Unusual breakpoint distribution of 8p abnormalities in T-prolymphocytic leukemia: a study with YACS mapping to 8p11-p12. (11063795)
2000
25
Recurrent molecular deletion of the 12p13 region, centromeric to ETV6/TEL, in T-cell prolymphocytic leukemia. (11920168)
2000
26
Improvement of quality of life after splenectomy in an HTLV-I carrier with T-cell prolymphocytic leukemia. (10609799)
1999
27
T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23). (10347553)
1999
28
B-cell prolymphocytic leukemia: a survey of 35 patients emphasizing heterogeneity, prognostic factors and evidence for a group with an indolent course. (10194135)
1999
29
Treatment of prolymphocytic leukemia with cladribine. (9540763)
1998
30
Abnormalities of the short arm of chromosome 12 in T cell prolymphocytic leukemia. (9639428)
1998
31
Treatment of T prolymphocytic leukemia with allogeneic bone marrow transplantation. (9580345)
1998
32
Complete remission in T-cell prolymphocytic leukemia with 2-chlorodeoxyadenosine. (7738636)
1995
33
Overexpression of the PRAD1 oncogene in a patient with prolymphocytic leukemia with t(11;14)(q13;q32). (7497446)
1995
34
Leukemic B-cell colony formation in patients with B-cell prolymphocytic leukemia]. (8479081)
1993
35
Three new monoclonal antibodies that define a unique antigen associated with prolymphocytic leukemia/non-Hodgkin's lymphoma and are effectively internalized after binding to the cell surface antigen. (8417805)
1993
36
Expression of immunoglobulin heavy chain variable gene (VH) in B-chronic lymphocytic leukemia (B-CLL) and B-prolymphocytic leukemia (B-PLL) cell lines. "Restricted" usage of VH3 family. (1318012)
1992
37
Efficacy of fludarabine, a new adenine nucleoside analogue, in patients with prolymphocytic leukemia and the prolymphocytoid variant of chronic lymphocytic leukemia. (1996592)
1991
38
Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T-prolymphocytic leukemia and T-cell leukemias in patients with ataxia telangiectasia. (1913594)
1991
39
Differential response of malignant human B-cells to anti-IgM immunoglobulin (anti-mu) and B-cell growth factor: unique direct cytotoxicity of anti-mu on prolymphocytic leukemia cells. (2119832)
1990
40
Analysis of T-cell-derived factors with the use of B-prolymphocytic leukemia cells. (3257174)
1988
41
B prolymphocytic leukemia cell lines: phenotype and response to B cell differentiation factor. (3259689)
1988
42
Fulminant leukemic polyradiculoneuropathy in a case of B-cell prolymphocytic leukemia. A clinicopathologic report. (3040217)
1987
43
Interleukin-2 can induce proliferation of leukemic B-cells in prolymphocytic leukemia. (3297775)
1987
44
An acquired Robertsonian translocation in prolymphocytic leukemia: a case presentation and review. (3470118)
1987
45
A new anthracycline regimen for prolymphocytic leukemia? Study of a case report with flow cytometric implications. (3479665)
1987
46
Right heart obstruction due to intracavitary prolymphocytic leukemia. (3460337)
1986
47
Six new cases of prolymphocytic leukemia with heterogeneous prognosis. Clinical and immunologic features, light microscopy, and ultrastructural findings. (3857957)
1985
48
Prolymphocytic leukemia: histologic findings in atypical cases. (6592135)
1984
49
Prolymphocytic leukemia with IgM hypogammaglobulinemia. (6603786)
1983
50
T-cell prolymphocytic leukemia with a suppressor phenotype. (6223570)
1983

Variations for Prolymphocytic Leukemia

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Expression for genes affiliated with Prolymphocytic Leukemia

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Expression patterns in normal tissues for genes affiliated with Prolymphocytic Leukemia

Search GEO for disease gene expression data for Prolymphocytic Leukemia.

Pathways for genes affiliated with Prolymphocytic Leukemia

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Pathways related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD38, CD19
2
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.2CD19, ZAP70
39.2CD19, ZAP70
49.2ZAP70, CD19
59.2CD19, ZAP70
69.1ZAP70, ATM
78.7ZAP70, CD5, CD19
88.5CD38, CD19, CD5, MS4A1

Compounds for genes affiliated with Prolymphocytic Leukemia

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ricin449.6CD19, CD5
2paraffin449.0CD5, ATM, MS4A1
3cyclophosphamide44 50 1110.9MS4A1, ZAP70
4fludarabine44 50 1110.9CD38, MS4A1, ZAP70
5rituximab44 50 1110.8MS4A1, ZAP70, CD38
6atp44 289.5CD38, ZAP70, ATM
7adp44 28 2410.4CD38, ZAP70, ATM
8phosphatidylinositol448.2CD38, ATM, CD19, ZAP70
9lipid447.8ATM, MS4A1, ZAP70, CD19, CD38
10calcium44 50 24 1110.7CD19, CD5, ZAP70, MS4A1, CD38
11tyrosine447.7ZAP70, CD5, CD19, CD38, ATM

GO Terms for genes affiliated with Prolymphocytic Leukemia

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Cellular components related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.1CD19, CD5, MS4A1
2external side of plasma membraneGO:0098978.8CD19, CD5, MS4A1

Biological processes related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:0508539.4CD38, CD19
2apoptotic signaling pathwayGO:0971909.2CD38, CD5
3protein autophosphorylationGO:0467779.1ZAP70, ATM
4response to hypoxiaGO:0016669.0CD38, ATM

Products for genes affiliated with Prolymphocytic Leukemia

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Sources for Prolymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet