MCID: PRL017
MIFTS: 47

Prolymphocytic Leukemia malady

Summaries for Prolymphocytic Leukemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Prolymphocytic leukemia is divided into two types according to the kind of cell involved: B-cell... more...

MalaCards: Prolymphocytic Leukemia, also known as leukemia prolymphocytic, is related to leukemia and t-cell leukemia. An important gene associated with Prolymphocytic Leukemia is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Apoptosis Pathway and PLK3 signaling events. The compounds neocarzinostatin and bpde have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone marrow, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Prolymphocytic Leukemia

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

prolymphocytic leukemia 8 10 60
leukemia prolymphocytic 44


External Ids:

Disease Ontology8 DOID:1039
NCIt39 C3181
MeSH34 D015463

Related Diseases for Prolymphocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Prolymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.9CD5, ETV6, IGKC, NFKB1, ANPEP, CHEK2
2t-cell leukemia31.6ATM, TCL1A, CD7, MTCP1, NFKB1, ZAP70
3chronic lymphocytic leukemia31.1CD52, TCL1A, MS4A1, ZAP70, CD38, CD5
4acute leukemia30.8SMARCB1, CD7, ANPEP, ATM, ETV6
5hodgkin's lymphoma30.4MS4A1, TCL1A, ATM, ZAP70
6ataxia telangiectasia30.3ATM, TP53, TCL1A, CHEK2, MTCP1
7sarcoma30.3SMARCB1, TP53, ANPEP, CHEK2, ETV6
8macroglobulinemia30.1CD5, CD19
9nijmegen breakage syndrome30.1ATM, CHEK2
10myeloid leukemia30.1ANPEP, ETV6, CD38
11breast cancer30.1ATM, CHEK2
12myeloma30.1TCL1A, ANPEP, CD38, CD19, IGKC
13acute lymphocytic leukemia30.1CD5, CD38, CD19, ETV6, CD7, ZAP70
14b cell prolymphocytic leukemia10.5
15hairy cell leukemia10.5
16t-cell prolymphocytic leukemia10.4
17graft versus host disease10.2
18splenic manifestation of prolymphocytic leukemia10.2
19acute t cell leukemia10.2
20central nervous system leukemia10.2
21mantle cell lymphoma10.2
22diffuse large b-cell lymphoma10.2
23t-cell large granular lymphocyte leukemia10.2
24meningitis10.2
25t-cell prolymphocytic leukemia, somatic10.2
26acute liver failure10.1
27richter's syndrome10.1
28adult t-cell leukemia10.1
29leukostasis10.1
30lymphosarcoma10.1
31adult syndrome10.1
32adult lymphoma10.1
33exanthem10.1
34gingivitis10.1
35malignant mesothelioma10.1
36panuveitis10.1
37polyradiculoneuropathy10.1
38rhabdomyosarcoma10.1
39t cell deficiency10.1
40thrombocytopenia10.1
41vasculitis10.1
42arthritis10.0ANPEP
43hepatitis10.0ANPEP
44hepatitis c10.0HLA-S
45amyloidosis10.0IGKC
46laryngeal squamous cell carcinoma10.0TP53
47deficiency anemia10.0CD5, CD19
48meningioma10.0SMARCB1
49severe combined immunodeficiency10.0CD38, ZAP70
50fanconi's anemia10.0ATM

Graphical network of the top 20 diseases related to Prolymphocytic Leukemia:



Diseases related to prolymphocytic leukemia

Clinical Features for Prolymphocytic Leukemia

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Drugs & Therapeutics for Prolymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Prolymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Prolymphocytic Leukemia

Search NIH Clinical Center for Prolymphocytic Leukemia

Search CenterWatch for Prolymphocytic Leukemia

Genetic Tests for Prolymphocytic Leukemia

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Anatomical Context for Prolymphocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Prolymphocytic Leukemia:

32
T cells, B cells, Bone marrow, Bone, Skin, Spleen, Heart, Myeloid, Breast, Liver, Lymph node, Eye, Endothelial, Small intestine

Animal Models for Prolymphocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Prolymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3CHEK2, ETV6, CD19, CDKN1B, SMARCB1
2MP:00028739.3TP53, CD52, CD19, CD5, ETV6, NFKB1
3MP:00053978.1IGKC, NFKB1, ANPEP, CHEK2, ATM, ZAP70
4MP:00053848.1ETV6, IGKC, NFKB1, CHEK2, ATM, ZAP70
5MP:00053878.0TP53, ZAP70, ATM, CHEK2, ANPEP, NFKB1

Publications for Prolymphocytic Leukemia

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50PubMed
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Articles related to Prolymphocytic Leukemia:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Smudge cells following treatment with pentostatin in a patient with B-cell prolymphocytic leukemia. (24049774)
2013
2
De Novo B-Cell Prolymphocytic Leukemia with Central Nervous System Involvement. (24047478)
2013
3
Coronary vasculitis associated with T-cell prolymphocytic leukemia. (23731632)
2013
4
T-cell prolymphocytic leukemia in Japan: is it a variant? (22527853)
2012
5
Erythematous eruption with marked conjunctival injection--quiz case. Diagnosis: leukemia cutis with conjunctival involvement in the setting of T-cell prolymphocytic leukemia (T-PLL). (23069962)
2012
6
A case report of T cell prolymphocytic leukemia and Kaposi sarcoma and a review of T cell prolymphocytic leukemia. (22517037)
2012
7
CD30-positive EBV-associated diffuse large B-cell lymphoma occurring after immunosuppressive therapy for T-cell prolymphocytic leukemia. (21454193)
2011
8
Concurrent chronic lymphocytic leukemia and prolymphocytic leukemia derived from two separate B-cell clones. (21465516)
2011
9
Alemtuzumab therapy in T-cell prolymphocytic leukemia: comparing efficacy in a series treated intravenously and a study piloting the subcutaneous route. (21948296)
2011
10
T-cell prolymphocytic leukemia: A rare disease in an elderly female. (21129072)
2010
11
Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition. (19480937)
2009
12
Skin involvement in T-cell prolymphocytic leukemia. (17707160)
2007
13
IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL). (16642047)
2006
14
T cell prolymphocytic leukemia: a rare cause of acute liver failure. (16615010)
2006
15
Small cell variant type of T-prolymphocytic leukemia with a four-year indolent course preceding acute exacerbation. (16840216)
2006
16
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
17
Rituximab-induced acute thrombocytopenia in a patient with prolymphocytic leukemia. (15609288)
2005
18
T-cell prolymphocytic leukemia: a single-institution experience. (16354329)
2005
19
T-cell prolymphocytic leukemia: update and focus on alemtuzumab (Campath-1H). (12623420)
2003
20
Indolent T-cell prolymphocytic leukemia: a case report and a review of the literature. (14508807)
2003
21
CD3-negative, CD20-positive T-cell prolymphocytic leukemia: case report and review of the literature. (12447967)
2002
22
T-cell receptor gammadelta T-cell leukemia with the morphology of T-cell prolymphocytic leukemia and a postthymic immunophenotype. (11797117)
2001
23
B-cell prolymphocytic leukemia: a survey of 35 patients emphasizing heterogeneity, prognostic factors and evidence for a group with an indolent course. (10194135)
1999
24
Treatment of T prolymphocytic leukemia with allogeneic bone marrow transplantation. (9580345)
1998
25
IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-kappaB induction and IL-2 receptor alpha expression. (9619918)
1998
26
14q11 abnormality and trisomy 8q are not common in Japanese T-cell prolymphocytic leukemia. (9846013)
1998
27
In vivo binding of mouse IgG via polyreactive surface IgM abrogates progressive lymphocytosis in prolymphocytic leukemia. (9684933)
1998
28
Prolymphocytic leukemia: diagnosis and treatment. A case report. (9392933)
1997
29
Biallelic mutations in the ATM gene in T-prolymphocytic leukemia. (9334731)
1997
30
Treatment of T-cell prolymphocytic leukemia with human CD52 antibody. (9215839)
1997
31
Similarities between T-cell chronic lymphocytic leukemia and the small-cell variant of T-prolymphocytic leukemia. (8605373)
1996
32
Overexpression of the PRAD1 oncogene in a patient with prolymphocytic leukemia with t(11;14)(q13;q32). (7497446)
1995
33
Leukemic meningitis in B-cell prolymphocytic leukemia. A clinical, pathologic, and ultrastructural case study and a review of the literature. (7850707)
1995
34
Multiple karyotypic abnormalities in three cases of small cell variant of T-cell prolymphocytic leukemia. (7987802)
1994
35
A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia. (8152252)
1994
36
Leukemic B-cell colony formation in patients with B-cell prolymphocytic leukemia]. (8479081)
1993
37
The pediatric rhabdomyosarcoma translocation (2;13)(q35;q14) in B-prolymphocytic leukemia. (8412333)
1993
38
Splenic irradiation as initial therapy for prolymphocytic leukemia. (1499697)
1992
39
Further characterization of prolymphocytic leukemia cells as a tumor of activated B cells. (2194392)
1990
40
Cytogenetic studies on prolymphocytic leukemia. 1. B-cell prolymphocytic leukemia. (3509770)
1987
41
Prolymphocytic leukemia treated by leukapheresis with relief of respiratory symptoms. (4027197)
1985
42
Enzymatic differences between chronic lymphocytic leukemia and prolymphocytic leukemia. (3934467)
1985
43
Prolymphocytic leukemia. Serial responses to therapy. (6590113)
1984
44
Prolymphocytic leukemia: postmortem findings after long-term survival. (6603026)
1983
45
J-5 antibody and prolymphocytic leukemia. (6626746)
1983
46
Chromosome abnormalities in B-cell prolymphocytic leukemia: a study of nine cases. (6603259)
1983
47
T-cell prolymphocytic leukemia. Clinical and immunologic characterization. (6226353)
1983
48
Cytoplasmic inclusions in a case of prolymphocytic leukemia. (6945802)
1981
49
Prolymphocytic leukemia. Response to asparaginase. (6934709)
1981
50
Prolymphocytic leukemia. An ultrastructural study. (7355854)
1980

Genetic Variations for Prolymphocytic Leukemia

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Expression for genes affiliated with Prolymphocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prolymphocytic Leukemia

Search GEO for disease gene expression data for Prolymphocytic Leukemia.

Pathways for genes affiliated with Prolymphocytic Leukemia

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Sources:
59Tocris Bioscience, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 49PharmGKB
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Pathways related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3ATM
210.2CHEK2, TP53
3
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10.2ATM, CHEK2
4
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
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10.0TP53, CHEK2, ATM
510.0ATM, CHEK2, TP53
610.0TP53, CHEK2, ATM
710.0TP53, CHEK2, ATM
8
DNA damage Role of Brca1 and Brca2 in DNA repair
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10.0ATM, CHEK2, TP53
9
Hide members
10.0ATM, CHEK2, TP53
10
Hide members
10.0TP53, CDKN1B, ATM
1110.0ATM, CDKN1B, TP53
12
Hide members
10.0CHEK2, NFKB1, TP53
1310.0NFKB1, ATM, ZAP70
14
Transcription P53 signaling pathway
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10.0TP53, NFKB1, ATM
15
Hide members
10.0TP53, CDKN1B, NFKB1
16
Hide members
10.0TP53, CDKN1B, NFKB1
17
Hide members
10.0TP53, CDKN1B, NFKB1
1810.0TP53, CDKN1B, NFKB1
19
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.0NFKB1, CDKN1B, TP53
2010.0CDKN1B, NFKB1, ATM
21
Immune response NFAT in immune response
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10.0IGKC, NFKB1, ZAP70
22
Hide members
9.8ATM, CHEK2, CDKN1B, TP53
23
Hide members
9.8ATM, CHEK2, CDKN1B, TP53
249.8TP53, SMARCB1, CHEK2, ATM
259.8ATM, CHEK2, NFKB1, TP53
269.8ATM, CHEK2, NFKB1, TP53
279.8ATM, CHEK2, NFKB1, TP53
28
Hide members
9.8ZAP70, NFKB1, IGKC, CD19
299.8TP53, CDKN1B, NFKB1, ATM
30
Hide members
9.8ATM, NFKB1, CDKN1B, TP53
31
Hide members
9.8ATM, NFKB1, CDKN1B, TP53
32
Hide members
9.8NFKB1, IGKC, CD19, CDKN1B
33
Hide members
9.8NFKB1, IGKC, CD19, CDKN1B
349.7NFKB1, CD19, CD38, CDKN1B, TP53
35
Hide members
9.7TP53, NFKB1, CHEK2, ATM, ZAP70
369.7TP53, CDKN1B, NFKB1, CHEK2, ATM
379.6ATM, NFKB1, ETV6, CDKN1B, TP53
389.5MS4A1, CD7, CD38, CD19, CD5, ANPEP
39
Hide members
9.5TP53, CDKN1B, NFKB1, CHEK2, ATM, ZAP70
409.4MTCP1, NFKB1, CD19, CDKN1B, TCL1A, TP53

Compounds for genes affiliated with Prolymphocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1neocarzinostatin4410.4ATM, CHEK2
2bpde4410.3TP53, CHEK2, ATM
3ricin4410.2CD5, CD19
4aphidicolin4410.2ATM, CHEK2, CDKN1B, TP53
5gemcitabine44 49 1112.2TP53, CDKN1B, CHEK2
6rituximab44 49 1112.2ZAP70, CD38, CD52, MS4A1
7camptothecin44 59 1112.1TP53, CDKN1B, CHEK2, ATM
8hydroxyurea44 49 1112.1ATM, CHEK2, TP53
9n acetylcysteine4410.1ATM, CHEK2, CDKN1B, TP53
10cyclophosphamide44 49 1112.0HLA-S, ZAP70, CDKN1B, MS4A1, TP53
11etoposide44 49 59 1113.0ATM, CHEK2, NFKB1, CDKN1B, TP53
12cytarabine44 49 1111.9TP53, CDKN1B, ATM
13paraffin449.9ATM, ANPEP, CD5, CDKN1B, MS4A1, TP53
14fludarabine44 1110.9TP53, MS4A1, CD52, CDKN1B, CD38, ZAP70
15doxorubicin44 49 1111.9ATM, CHEK2, ANPEP, CD19, CDKN1B, TP53
16phosphatidylinositol449.8ZAP70, ATM, CHEK2, CD19, CD38, CDKN1B
17serine449.8TCL1A, CDKN1B, ANPEP, CHEK2
18atp44 2810.7ZAP70, ATM, CHEK2, ANPEP, CD38, CDKN1B
19threonine449.7ZAP70, ATM, CHEK2, ANPEP, CDKN1B, TCL1A
20oligonucleotide449.7TP53, CDKN1B, ANPEP, CHEK2, ZAP70
21retinoic acid44 2410.6CHEK2, ANPEP, ETV6, CD38, CDKN1B, TP53
22wortmannin449.5ATM, CHEK2, ANPEP, CDKN1B
23tyrosine449.3ZAP70, ATM, CHEK2, ANPEP, ETV6, CD5

GO Terms for genes affiliated with Prolymphocytic Leukemia

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16Gene Ontology
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Cellular components related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6MS4A1, CD19, CD5, ANPEP
2nucleoplasmGO:0056549.5CHEK2, NFKB1, CDKN1B, SMARCB1, TP53, ATM

Biological processes related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.2CHEK2, ATM
2replicative senescenceGO:09039910.2TP53, CHEK2, ATM
3double-strand break repairGO:00630210.0TP53, CHEK2, ATM, BRCC3
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.0ATM, CDKN1B, TP53
5Fc-epsilon receptor signaling pathwayGO:0380959.9NFKB1, IGKC, CD19, CDKN1B
6mitotic cell cycle arrestGO:0718509.9CDKN1B, TP53
7immune responseGO:0069559.8MS4A1, CD7, IGKC, ZAP70
8negative regulation of apoptotic processGO:0430669.6TP53, CDKN1B, CD38, NFKB1, ATM

Products for genes affiliated with Prolymphocytic Leukemia

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  • Antibodies
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Sources for Prolymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet