MCID: PRL017
MIFTS: 41

Prolymphocytic Leukemia malady

Summaries for Prolymphocytic Leukemia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Prolymphocytic leukemia is divided into two types according to the kind of cell involved: B-cell... more...

MalaCards: Prolymphocytic Leukemia, also known as leukemia prolymphocytic, is related to t-cell leukemia and acute leukemia. An important gene associated with Prolymphocytic Leukemia is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Apoptosis Pathway and PLK3 signaling events. The compounds neocarzinostatin and bpde have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Prolymphocytic Leukemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

prolymphocytic leukemia 8 10 61
leukemia prolymphocytic 45


External Ids:

Disease Ontology8 DOID:1039
NCIt40 C3181
MeSH35 D015463

Related Diseases for Prolymphocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Prolymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia31.4ZAP70, ATM, MTCP1, NFKB1, CD7, TCL1A
2acute leukemia30.8ATM, ANPEP, ETV6, CD7, SMARCB1
3ataxia telangiectasia30.3ATM, MTCP1, CHEK2, TCL1A, TP53
4macroglobulinemia30.1CD19, CD5
5macroglobulinemia, waldenstrom, somatic30.1MS4A1, ZAP70
6nijmegen breakage syndrome30.1ATM, CHEK2
7acute lymphocytic leukemia30.1ZAP70, ANPEP, ETV6, CD5, CD19, CD38
8t-cell prolymphocytic leukemia11.0
9b cell prolymphocytic leukemia10.8
10leukemia/lymphoma, t-cell10.4
11graft versus host disease10.2
12richter's syndrome10.2
13splenic manifestation of prolymphocytic leukemia10.2
14central nervous system leukemia10.2
15kaposi's sarcoma10.2
16mantle cell lymphoma10.2
17leukemia, t-cell, chronic10.2
18ataxia10.2
19t-cell prolymphocytic leukemia, somatic10.2
20lymphoma, diffuse large cell10.2
21acute liver failure10.1
22acute t cell leukemia10.1
23leukostasis10.1
24lymphosarcoma10.1
25adult syndrome10.1
26adult lymphoma10.1
27diffuse large b-cell lymphoma10.1
28n syndrome10.1
29thrombocytopenia10.1
30vasculitis10.1
31acute graft versus host disease10.1
32cold agglutinin disease10.1
33chronic graft versus host disease10.1
34large granular lymphocyte leukemia10.1
35waldenstrom macroglobulinemia10.1
36guillain-barr� syndrome10.1
37hematopoietic stem cell transplantation10.1
38arthritis10.0ANPEP
39hepatitis10.0ANPEP
40hepatitis c10.0HLA-S
41amyloidosis10.0IGKC
42laryngeal squamous cell carcinoma10.0TP53
43deficiency anemia10.0CD5, CD19
44meningioma10.0SMARCB1
45severe combined immunodeficiency10.0CD38, ZAP70
46fanconi's anemia10.0ATM
47esophageal cancer10.0TP53
48hypersensitivity reaction type ii disease10.0CD19, CD5
49gastrointestinal system disease10.0CD19
50bloom syndrome10.0ATM

Graphical network of the top 20 diseases related to Prolymphocytic Leukemia:



Diseases related to prolymphocytic leukemia

Clinical Features for Prolymphocytic Leukemia

Drugs & Therapeutics for Prolymphocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Prolymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Prolymphocytic Leukemia

Search NIH Clinical Center for Prolymphocytic Leukemia

Search CenterWatch for Prolymphocytic Leukemia

Genetic Tests for Prolymphocytic Leukemia

Anatomical Context for Prolymphocytic Leukemia

Animal Models for Prolymphocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Prolymphocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.3CHEK2, ETV6, CD19, CDKN1B, SMARCB1
2MP:00028739.3TP53, CD52, CD19, CD5, ETV6, NFKB1
3MP:00053978.1TP53, ATM, CHEK2, ANPEP, NFKB1, IGKC
4MP:00053848.1CD19, TP53, SMARCB1, MS4A1, CDKN1B, CD7
5MP:00053878.0ZAP70, SMARCB1, MS4A1, CDKN1B, CD7, CD38

Publications for Prolymphocytic Leukemia

Sources:
51PubMed
See all sources

Articles related to Prolymphocytic Leukemia:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
T-cell prolymphocytic leukemia (T-PLL) with overlapping cytomorphological features with T-CLL and T-ALL: a case initially diagnosed by fine-needle aspiration cytology and immunocytochemistry. (21987484)
2013
2
Splenic rupture associated with aggressive conversion of indolent T-cell prolymphocytic leukemia]. (23676644)
2013
3
Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course. (22205151)
2012
4
T cell-prolymphocytic leukemia detected in a patient of breast cancer at the time of recurrence: a case report. (20076807)
2010
5
Array comparative genomic hybridization in the detection of chromosomal abnormalities in T-cell prolymphocytic leukemia. (20804923)
2010
6
CD5-positive B-cell prolymphocytic leukemia]. (20134145)
2010
7
Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia. (18294235)
2009
8
Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy. (19278963)
2009
9
Rhodococcus equi infection after alemtuzumab therapy for T-cell prolymphocytic leukemia. (18258054)
2007
10
Clinically and genetically atypical T-cell prolymphocytic leukemia underlines the relevance of a multidisciplinary diagnostic approach. (17405754)
2007
11
Bortezomib induces apoptosis in T-cell prolymphocytic leukemia (T-PLL). (17990182)
2007
12
Production of vascular endothelial growth factor in T-cell prolymphocytic leukemia. (16620970)
2007
13
Small cell variant of T-cell prolymphocytic leukemia with a gammadelta immunophenotype. (15717692)
2005
14
Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia. (15066324)
2004
15
High levels of chromosomal imbalances in typical and small-cell variants of T-cell prolymphocytic leukemia. (14580769)
2003
16
Cytomegalovirus viremia during Campath-1H therapy for relapsed and refractory chronic lymphocytic leukemia and prolymphocytic leukemia. (12435283)
2002
17
Nucleolated variant of mantle cell lymphoma with leukemic manifestations mimicking prolymphocytic leukemia. (11865846)
2002
18
Application of cross-species color banding (RxFISH) in the study of T-prolymphocytic leukemia. (10870117)
2000
19
Unusual breakpoint distribution of 8p abnormalities in T-prolymphocytic leukemia: a study with YACS mapping to 8p11-p12. (11063795)
2000
20
Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL). (10720137)
2000
21
Seropositive polyarthritis and skin manifestations in T-prolymphocytic leukemia/Sezary cell leukemia variant. (10752996)
2000
22
A new case of SAczary cell leukemia: a morphological variant of prolymphocytic leukemia. (10897140)
2000
23
Serum levels of parathyroid hormone-related protein are not elevated in patients with T-cell prolymphocytic leukemia. (10525829)
1999
24
Treatment of prolymphocytic leukemia with cladribine. (9540763)
1998
25
Abnormalities of chromosomes 8, 11, 14, and X in T-prolymphocytic leukemia studied by fluorescence in situ hybridization. (9614908)
1998
26
Major activity of cladribine in patients with de novo B-cell prolymphocytic leukemia. (8996122)
1997
27
Leukemic meningitis in a patient with B-cell prolymphocytic leukemia. (9299880)
1997
28
Salvage chemotherapy with pentostatin in prolymphocytic leukemia. (7896214)
1994
29
Possible presence of T-cell progenitors in a population of B-prolymphocytic leukemia cells. (8092135)
1994
30
Three new monoclonal antibodies that define a unique antigen associated with prolymphocytic leukemia/non-Hodgkin's lymphoma and are effectively internalized after binding to the cell surface antigen. (8417805)
1993
31
Acute tumor lysis syndrome complicating fludarabine treatment of prolymphocytic leukemia. (8275684)
1993
32
Pentostatin in prolymphocytic leukemia: phase II trial of the European Organization for Research and Treatment of Cancer Leukemia Cooperative Study Group. (8468724)
1993
33
CD5+, CD11C+, trap-positive chronic lymphocytic leukemia/prolymphocytic leukemia. (1379851)
1992
34
Induction of apoptosis in CD4+ prolymphocytic leukemia by deoxyadenosine and 2'-deoxycoformycin. (1528066)
1992
35
Sustained response of refractory prolymphocytic leukemia to fludarabine. (1853684)
1991
36
Purine metabolism enzymes and immunological phenotype in chronic B-cell malignancies: chronic lymphocytic leukemia, prolymphocytic leukemia and hairy cell leukemia. (2125699)
1990
37
Acute tumor lysis syndrome in prolymphocytic leukemia. (2337111)
1990
38
Expression of the mdr3 gene in prolymphocytic leukemia: association with cyclosporin-A-induced increase in drug accumulation. (2323839)
1990
39
Prolymphocytic leukemia with suppressor T-cell phenotype: report of two cases. (2523211)
1989
40
T-prolymphocytic leukemia with circulating carrot-like cells. (3259691)
1988
41
Interleukin-2 can induce proliferation of leukemic B-cells in prolymphocytic leukemia. (3297775)
1987
42
Cytogenetic studies on prolymphocytic leukemia. II. T cell prolymphocytic leukemia. (3115337)
1987
43
Right heart obstruction due to intracavitary prolymphocytic leukemia. (3460337)
1986
44
Six new cases of prolymphocytic leukemia with heterogeneous prognosis. Clinical and immunologic features, light microscopy, and ultrastructural findings. (3857957)
1985
45
Prolymphocytic leukemia of B cell type: rearranged immunoglobulin (Ig) genes with defective Ig production. (2990609)
1985
46
Cytoplasmic inclusions and X-ray microprobe analysis in a case of prolymphocytic leukemia. (6330123)
1984
47
T-cell prolymphocytic leukemia with helper-cell phenotype and a review of the literature. (6234057)
1984
48
Complete remission in prolymphocytic leukemia with 4-demethoxydaunorubicin and arabinosyl cytosine. (6586276)
1984
49
Karyotypic findings in a case of prolymphocytic leukemia with a history of radiation exposure. (6309359)
1983
50
Prolymphocytic leukemia: treatment with combination chemotherapy to include doxorubicin. (6950800)
1982

Genetic Variations for Prolymphocytic Leukemia

Expression for genes affiliated with Prolymphocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prolymphocytic Leukemia

Search GEO for disease gene expression data for Prolymphocytic Leukemia.

Pathways for genes affiliated with Prolymphocytic Leukemia

Sources:
60Tocris Bioscience, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN, 30KEGG, 50PharmGKB
See all sources

Pathways related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3ATM
210.2TP53, CHEK2
3
Hide members
10.2CHEK2, ATM
4
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.0CHEK2, ATM, TP53
510.0ATM, CHEK2, TP53
610.0CHEK2, TP53, ATM
7
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
Hide members
10.0TP53, CHEK2, ATM
810.0CHEK2, TP53, ATM
9
Hide members
10.0CHEK2, TP53, ATM
1010.0ATM, CDKN1B, TP53
11
Hide members
10.0ATM, CDKN1B, TP53
12
Hide members
10.0TP53, NFKB1, CHEK2
1310.0ZAP70, ATM, NFKB1
14
Transcription P53 signaling pathway
Hide members
10.0TP53, ATM, NFKB1
15
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.0TP53, CDKN1B, NFKB1
16
Hide members
10.0TP53, CDKN1B, NFKB1
17
Hide members
10.0NFKB1, CDKN1B, TP53
18
Hide members
10.0CDKN1B, TP53, NFKB1
1910.0NFKB1, CDKN1B, TP53
2010.0ATM, CDKN1B, NFKB1
21
Immune response NFAT in immune response
Hide members
10.0ZAP70, NFKB1, IGKC
22
Hide members
9.8TP53, CDKN1B, CHEK2, ATM
23
Hide members
9.8ATM, TP53, CDKN1B, CHEK2
249.8ATM, TP53, CHEK2, SMARCB1
259.8TP53, NFKB1, CHEK2, ATM
269.8TP53, NFKB1, CHEK2, ATM
279.8CHEK2, TP53, NFKB1, ATM
28
Hide members
9.8ZAP70, NFKB1, CD19, IGKC
29
Hide members
9.8TP53, CDKN1B, NFKB1, ATM
309.8NFKB1, ATM, CDKN1B, TP53
31
Hide members
9.8NFKB1, ATM, TP53, CDKN1B
32
Hide members
9.8CD19, IGKC, NFKB1, CDKN1B
33
Hide members
9.8CD19, CDKN1B, NFKB1, IGKC
349.7TP53, CD19, NFKB1, CDKN1B, CD38
35
Hide members
9.7ZAP70, ATM, CHEK2, TP53, NFKB1
369.7CDKN1B, ATM, CHEK2, NFKB1, TP53
379.6TP53, ATM, NFKB1, ETV6, CDKN1B
389.5ANPEP, CD5, CD19, CD38, CD7, MS4A1
39
Hide members
9.5CDKN1B, TP53, CHEK2, ZAP70, ATM, NFKB1
409.4MTCP1, NFKB1, CD19, CDKN1B, TCL1A, TP53

Compounds for genes affiliated with Prolymphocytic Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1neocarzinostatin4510.4CHEK2, ATM
2bpde4510.3CHEK2, ATM, TP53
3ricin4510.2CD19, CD5
4aphidicolin4510.2TP53, CDKN1B, CHEK2, ATM
5gemcitabine45 50 1112.2TP53, CDKN1B, CHEK2
6rituximab45 50 1112.2CD38, ZAP70, CD52, MS4A1
7camptothecin45 60 1112.1TP53, CDKN1B, CHEK2, ATM
8hydroxyurea45 50 1112.1ATM, TP53, CHEK2
9n acetylcysteine4510.1ATM, CHEK2, CDKN1B, TP53
10cyclophosphamide45 50 1112.0ZAP70, HLA-S, TP53, MS4A1, CDKN1B
11etoposide45 50 60 1113.0ATM, CDKN1B, TP53, NFKB1, CHEK2
12cytarabine45 50 1111.9ATM, CDKN1B, TP53
13paraffin459.9CD5, MS4A1, TP53, ANPEP, ATM, CDKN1B
14fludarabine45 1110.9CD38, TP53, MS4A1, CD52, CDKN1B, ZAP70
15doxorubicin45 50 1111.9ANPEP, CHEK2, CD19, CDKN1B, TP53, ATM
16phosphatidylinositol459.8ZAP70, ATM, CHEK2, CD19, CDKN1B, CD38
17serine459.8TCL1A, CDKN1B, ANPEP, CHEK2
18atp45 2910.7CHEK2, ATM, ZAP70, ANPEP, CDKN1B, CD38
19threonine459.7CDKN1B, CHEK2, ATM, ZAP70, ANPEP, TCL1A
20oligonucleotide459.7ANPEP, CHEK2, ZAP70, CDKN1B, TP53
21retinoic acid45 2410.6ETV6, CHEK2, ANPEP, CD38, CDKN1B, TP53
22wortmannin459.5ATM, CDKN1B, ANPEP, CHEK2
23tyrosine459.3ZAP70, ANPEP, CDKN1B, CD38, CD19, CD5

GO Terms for genes affiliated with Prolymphocytic Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6ANPEP, CD5, CD19, MS4A1
2nucleoplasmGO:0056549.5ATM, CHEK2, NFKB1, CDKN1B, SMARCB1, TP53

Biological processes related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1DNA damage induced protein phosphorylationGO:00697510.2ATM, CHEK2
2replicative senescenceGO:09039910.2ATM, CHEK2, TP53
3double-strand break repairGO:00630210.0TP53, CHEK2, ATM, BRCC3
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00697710.0CDKN1B, ATM, TP53
5Fc-epsilon receptor signaling pathwayGO:0380959.9CDKN1B, NFKB1, IGKC, CD19
6mitotic cell cycle arrestGO:0718509.9TP53, CDKN1B
7immune responseGO:0069559.8ZAP70, IGKC, CD7, MS4A1
8negative regulation of apoptotic processGO:0430669.6ATM, NFKB1, CD38, CDKN1B, TP53

Products for genes affiliated with Prolymphocytic Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prolymphocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet