MCID: PRL017
MIFTS: 36

Prolymphocytic Leukemia malady

Summaries for Prolymphocytic Leukemia

About this section


Wikipedia:63 Prolymphocytic leukemia is divided into two types according to the kind of cell involved: B-cell... more...

MalaCards based summary: Prolymphocytic Leukemia, also known as leukemia prolymphocytic, is related to leukemia and macroglobulinemia. An important gene associated with Prolymphocytic Leukemia is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Epstein-Barr virus infection and B Cell Receptor Signaling Pathway. The compounds ricin and paraffin have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone marrow, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Prolymphocytic Leukemia

About this section
Sources:
9Disease Ontology, 11DISEASES, 60UMLS, 43Novoseek, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Prolymphocytic Leukemia, Aliases & Descriptions:

Name: Prolymphocytic Leukemia 9 11 60
 
Leukemia Prolymphocytic 43


External Ids:

Disease Ontology9 DOID:1039
NCIt38 C3181
MeSH33 D015463

Related Diseases for Prolymphocytic Leukemia

About this section

Diseases related to Prolymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0ATM, ZAP70, CD5, CD19, CD38
2macroglobulinemia30.5CD5, CD19
3t-cell leukemia30.3ZAP70, ATM
4chronic lymphocytic leukemia30.2ATM, MS4A1, ZAP70, CD5, CD38
5b-cell lymphomas29.6ATM, MS4A1, ZAP70, CD5, CD19
6acute biphenotypic leukemia10.5
7splenic manifestation of prolymphocytic leukemia10.4
8hematopoietic stem cell transplantation10.4
9mantle cell lymphoma10.4
10blastic plasmacytoid dendritic cell10.4
11large granular lymphocyte leukemia10.4
12kaposi sarcoma10.3
13ataxia-telangiectasia10.3
14diffuse large b-cell lymphoma10.3
15t-cell large granular lymphocyte leukemia10.3
16meningitis10.3
17sarcoma10.3
18ataxia10.3
19breast cancer10.1
20nijmegen breakage syndrome10.1
21myocardial infarction10.1
22acute leukemia10.1
23acute liver failure10.1
24adult t-cell leukemia10.1
25hemolytic anemia10.1
26thrombocytopenia10.1
27richter's syndrome10.1
28pure red-cell aplasia10.1
29leukostasis10.1
30autoimmune hemolytic anemia10.1
31lymphosarcoma10.1
32hypercalcemia10.1
33anterior scleritis10.1
34exanthem10.1
35gingivitis10.1
36myeloma10.1
37panuveitis10.1
38polyradiculoneuropathy10.1
39rhabdomyosarcoma10.1
40scleritis10.1
41thyroiditis10.1
42vasculitis10.1
43acute graft versus host disease10.1
44cold agglutinin disease10.1
45endotheliitis10.1
46mesothelioma10.1
47agammaglobulinemia10.1CD38, CD19
48hypersensitivity reaction type ii disease10.1CD5, CD19
49waldenstrom macroglobulinemia10.0ZAP70, MS4A1
50deficiency anemia10.0CD19, CD5

Graphical network of the top 20 diseases related to Prolymphocytic Leukemia:



Diseases related to prolymphocytic leukemia

Symptoms for Prolymphocytic Leukemia

About this section

Drugs & Therapeutics for Prolymphocytic Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Prolymphocytic Leukemia

Search NIH Clinical Center for Prolymphocytic Leukemia

Genetic Tests for Prolymphocytic Leukemia

About this section

Anatomical Context for Prolymphocytic Leukemia

About this section

MalaCards organs/tissues related to Prolymphocytic Leukemia:

31
T cells, B cells, Bone marrow, Bone, Skin, Spleen, Heart, Eye, Lymph node, Brain, Liver, Thyroid, Breast, Myeloid, Endothelial, Small intestine

Animal Models for Prolymphocytic Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Prolymphocytic Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1MS4A1, ZAP70, CD5, CD19, CD38, ATM
2MP:00053976.8CD38, CD19, CD5, ZAP70, MS4A1, ATM

Publications for Prolymphocytic Leukemia

About this section

Articles related to Prolymphocytic Leukemia:

(show top 50)    (show all 293)
idTitleAuthorsYear
1
Aberrations of MYC are a common event in B-cell prolymphocytic leukemia. (25125625)
2014
2
T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. (25238936)
2014
3
Immunophenotypic characterization of T-cell prolymphocytic leukemia. (24124154)
2013
4
Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia. (24048415)
2013
5
T-cell prolymphocytic leukemia in Japan: is it a variant? (22527853)
2012
6
Generalized purpuric drug exanthem with hemorrhagic plaques following bendamustine chemotherapy in a patient with B-prolymphocytic leukemia. (22290027)
2012
7
Guillain-BarrAc syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: a case report and review of the literature. (20362332)
2010
8
The evolving management of a rare lymphoproliferative disorder-T-cell prolymphocytic leukemia. (19714590)
2009
9
Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition. (19480937)
2009
10
Rhodococcus equi infection after alemtuzumab therapy for T-cell prolymphocytic leukemia. (18258054)
2007
11
Mature T-cell leukemias including T-prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and SAczary syndrome. (17369126)
2007
12
Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia. (17898784)
2007
13
Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia. (16997373)
2007
14
IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL). (16642047)
2006
15
T-cell prolymphocytic leukemia involving extramedullary sites. (15716243)
2005
16
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
17
An indolent case of T-prolymphocytic leukemia with t(3;22)(q21;q11.2) and elevated serum beta2-microglobulin. (16119992)
2005
18
T- cell prolymphocytic leukemia - a rare case. (16141512)
2005
19
Development of malignant mesothelioma during treatment for prolymphocytic leukemia: is asbestos or simian virus 40 a link? (15816607)
2005
20
Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia. (15066324)
2004
21
Complex karyotype in one patient with small cell variant of T-prolymphocytic leukemia. Analysis by G-banding and comparative genomic hybridization. (11255284)
2001
22
Application of cross-species color banding (RxFISH) in the study of T-prolymphocytic leukemia. (10870117)
2000
23
Unusual breakpoint distribution of 8p abnormalities in T-prolymphocytic leukemia: a study with YACS mapping to 8p11-p12. (11063795)
2000
24
Recurrent molecular deletion of the 12p13 region, centromeric to ETV6/TEL, in T-cell prolymphocytic leukemia. (11920168)
2000
25
Improvement of quality of life after splenectomy in an HTLV-I carrier with T-cell prolymphocytic leukemia. (10609799)
1999
26
T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23). (10347553)
1999
27
B-cell prolymphocytic leukemia: a survey of 35 patients emphasizing heterogeneity, prognostic factors and evidence for a group with an indolent course. (10194135)
1999
28
Treatment of prolymphocytic leukemia with cladribine. (9540763)
1998
29
Abnormalities of the short arm of chromosome 12 in T cell prolymphocytic leukemia. (9639428)
1998
30
Treatment of T prolymphocytic leukemia with allogeneic bone marrow transplantation. (9580345)
1998
31
Abnormalities of chromosomes 8, 11, 14, and X in T-prolymphocytic leukemia studied by fluorescence in situ hybridization. (9614908)
1998
32
Complete remission in T-cell prolymphocytic leukemia with 2-chlorodeoxyadenosine. (7738636)
1995
33
Overexpression of the PRAD1 oncogene in a patient with prolymphocytic leukemia with t(11;14)(q13;q32). (7497446)
1995
34
Leukemic B-cell colony formation in patients with B-cell prolymphocytic leukemia]. (8479081)
1993
35
Three new monoclonal antibodies that define a unique antigen associated with prolymphocytic leukemia/non-Hodgkin's lymphoma and are effectively internalized after binding to the cell surface antigen. (8417805)
1993
36
Expression of immunoglobulin heavy chain variable gene (VH) in B-chronic lymphocytic leukemia (B-CLL) and B-prolymphocytic leukemia (B-PLL) cell lines. "Restricted" usage of VH3 family. (1318012)
1992
37
Efficacy of fludarabine, a new adenine nucleoside analogue, in patients with prolymphocytic leukemia and the prolymphocytoid variant of chronic lymphocytic leukemia. (1996592)
1991
38
Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T-prolymphocytic leukemia and T-cell leukemias in patients with ataxia telangiectasia. (1913594)
1991
39
Differential response of malignant human B-cells to anti-IgM immunoglobulin (anti-mu) and B-cell growth factor: unique direct cytotoxicity of anti-mu on prolymphocytic leukemia cells. (2119832)
1990
40
Analysis of T-cell-derived factors with the use of B-prolymphocytic leukemia cells. (3257174)
1988
41
B prolymphocytic leukemia cell lines: phenotype and response to B cell differentiation factor. (3259689)
1988
42
Fulminant leukemic polyradiculoneuropathy in a case of B-cell prolymphocytic leukemia. A clinicopathologic report. (3040217)
1987
43
Interleukin-2 can induce proliferation of leukemic B-cells in prolymphocytic leukemia. (3297775)
1987
44
An acquired Robertsonian translocation in prolymphocytic leukemia: a case presentation and review. (3470118)
1987
45
A new anthracycline regimen for prolymphocytic leukemia? Study of a case report with flow cytometric implications. (3479665)
1987
46
Right heart obstruction due to intracavitary prolymphocytic leukemia. (3460337)
1986
47
Six new cases of prolymphocytic leukemia with heterogeneous prognosis. Clinical and immunologic features, light microscopy, and ultrastructural findings. (3857957)
1985
48
Prolymphocytic leukemia: histologic findings in atypical cases. (6592135)
1984
49
Prolymphocytic leukemia with IgM hypogammaglobulinemia. (6603786)
1983
50
T-cell prolymphocytic leukemia with a suppressor phenotype. (6223570)
1983

Variations for Prolymphocytic Leukemia

About this section

Expression for genes affiliated with Prolymphocytic Leukemia

About this section
Search GEO for disease gene expression data for Prolymphocytic Leukemia.

Pathways for genes affiliated with Prolymphocytic Leukemia

About this section

Pathways related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD38, CD19
2
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.2CD19, ZAP70
39.2CD19, ZAP70
49.2ZAP70, CD19
59.2CD19, ZAP70
69.1ZAP70, ATM
78.7ZAP70, CD5, CD19
88.5CD38, CD19, CD5, MS4A1

Compounds for genes affiliated with Prolymphocytic Leukemia

About this section
Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ricin439.6CD19, CD5
2paraffin439.0ATM, MS4A1, CD5
3cyclophosphamide43 49 1210.9ZAP70, MS4A1
4fludarabine43 49 1210.9CD38, ZAP70, MS4A1
5rituximab43 49 1210.8CD38, ZAP70, MS4A1
6atp43 289.5CD38, ZAP70, ATM
7adp43 28 2410.4CD38, ZAP70, ATM
8phosphatidylinositol438.2ATM, ZAP70, CD19, CD38
9lipid437.8ATM, MS4A1, ZAP70, CD19, CD38
10calcium43 49 24 1210.7MS4A1, ZAP70, CD5, CD19, CD38
11tyrosine437.7CD38, CD19, CD5, ZAP70, ATM

GO Terms for genes affiliated with Prolymphocytic Leukemia

About this section

Cellular components related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058879.1CD19, CD5, MS4A1
2external side of plasma membraneGO:00098978.8CD19, CD5, MS4A1

Biological processes related to Prolymphocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:00508539.4CD38, CD19
2apoptotic signaling pathwayGO:00971909.2CD38, CD5
3protein autophosphorylationGO:00467779.1ZAP70, ATM
4response to hypoxiaGO:00016669.0CD38, ATM

Products for genes affiliated with Prolymphocytic Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Prolymphocytic Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet