MCID: PRL017
MIFTS: 43

Prolymphocytic Leukemia malady

Cancer diseases category
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Summaries for Prolymphocytic Leukemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Prolymphocytic leukemia is divided into two types according to the kind of cell involved: B-cell... more...

MalaCards: Prolymphocytic Leukemia, also known as leukemia prolymphocytic, is related to leukemia and chronic lymphocytic leukemia. An important gene associated with Prolymphocytic Leukemia is MS4A1 (membrane-spanning 4-domains, subfamily A, member 1), and among its related pathways are Epstein-Barr virus infection and B Cell Receptor Signaling Pathway. The compounds ricin and paraffin have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone marrow, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Prolymphocytic Leukemia

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8Disease Ontology, 10DISEASES, 62UMLS, 45Novoseek, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

prolymphocytic leukemia 8 10 62
leukemia prolymphocytic 45


External Ids:

Disease Ontology8 DOID:1039
NCIt40 C3181
MeSH35 D015463

Related Diseases for Prolymphocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Prolymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.8ATM, ZAP70, CD5, CD19, CD38
2chronic lymphocytic leukemia30.8CD38, CD19, CD5, ZAP70, MS4A1, ATM
3hodgkin's lymphoma30.5ATM, MS4A1, ZAP70
4t-cell leukemia30.4ZAP70, ATM
5macroglobulinemia30.2CD5, CD19
6b-cell lymphomas30.2ATM, MS4A1, ZAP70, CD5, CD19
7b-cell chronic lymphocytic leukemia30.1MS4A1, ZAP70, CD5
8t-cell prolymphocytic leukemia11.1
9b cell prolymphocytic leukemia10.9
10hairy cell leukemia10.5
11graft versus host disease10.3
12splenic manifestation of prolymphocytic leukemia10.3
13ataxia telangiectasia10.3
14diffuse large b-cell lymphoma10.3
15mantle cell lymphoma10.3
16meningitis10.3
17sarcoma10.3
18large granular lymphocyte leukemia10.3
19ataxia10.3
20t-cell prolymphocytic leukemia, somatic10.3
21acute liver failure10.1
22richter's syndrome10.1
23leukostasis10.1
24nijmegen breakage syndrome10.1
25lymphosarcoma10.1
26acute leukemia10.1
27adult t-cell leukemia10.1
28t-cell large granular lymphocyte leukemia10.1
29breast cancer10.1
30exanthem10.1
31gingivitis10.1
32malignant mesothelioma10.1
33myeloma10.1
34panuveitis10.1
35polyradiculoneuropathy10.1
36rhabdomyosarcoma10.1
37thrombocytopenia10.1
38vasculitis10.1
39acute graft versus host disease10.1
40cold agglutinin disease10.1
41endotheliitis10.1
42hematopoietic stem cell transplantation10.1
43agammaglobulinemia10.0CD38, CD19
44hypersensitivity reaction type ii disease10.0CD5, CD19
45macroglobulinemia, waldenstrom, somatic10.0ZAP70, MS4A1
46deficiency anemia10.0CD19, CD5
47multiple myeloma10.0CD38, CD19
48malt lymphoma10.0ZAP70, CD5
49lymphopenia10.0ZAP70, ATM
50severe combined immunodeficiency10.0CD38, ZAP70

Graphical network of the top 20 diseases related to Prolymphocytic Leukemia:



Diseases related to prolymphocytic leukemia

Symptoms for Prolymphocytic Leukemia

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Drugs & Therapeutics for Prolymphocytic Leukemia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Prolymphocytic Leukemia

Search NIH Clinical Center for Prolymphocytic Leukemia

Genetic Tests for Prolymphocytic Leukemia

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Anatomical Context for Prolymphocytic Leukemia

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33MalaCards
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MalaCards organs/tissues related to Prolymphocytic Leukemia:

33
T cells, B cells, Bone marrow, Bone, Skin, Spleen, Myeloid, Breast, Liver, Heart, Lymph node, Eye, Endothelial, Small intestine

Animal Models for Prolymphocytic Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Prolymphocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.1MS4A1, ZAP70, CD5, CD19, CD38, ATM
2MP:00053976.8CD38, CD19, CD5, ZAP70, MS4A1, ATM

Publications for Prolymphocytic Leukemia

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52PubMed
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Articles related to Prolymphocytic Leukemia:

(show top 50)    (show all 270)
idTitleAuthorsYear
1
Immunophenotypic characterization of T-cell prolymphocytic leukemia. (24124154)
2013
2
Smudge cells following treatment with pentostatin in a patient with B-cell prolymphocytic leukemia. (24049774)
2013
3
Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia. (24048415)
2013
4
Cutaneous presentation of T-cell prolymphocytic leukemia. (23513557)
2013
5
T-cell prolymphocytic leukemia in Japan: is it a variant? (22527853)
2012
6
Generalized purpuric drug exanthem with hemorrhagic plaques following bendamustine chemotherapy in a patient with B-prolymphocytic leukemia. (22290027)
2012
7
Guillain-BarrAc syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: a case report and review of the literature. (20362332)
2010
8
The evolving management of a rare lymphoproliferative disorder-T-cell prolymphocytic leukemia. (19714590)
2009
9
Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition. (19480937)
2009
10
Rhodococcus equi infection after alemtuzumab therapy for T-cell prolymphocytic leukemia. (18258054)
2007
11
Mature T-cell leukemias including T-prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and SAczary syndrome. (17369126)
2007
12
Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia. (17898784)
2007
13
Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia. (16997373)
2007
14
Clinically and genetically atypical T-cell prolymphocytic leukemia underlines the relevance of a multidisciplinary diagnostic approach. (17405754)
2007
15
IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL). (16642047)
2006
16
T-cell prolymphocytic leukemia involving extramedullary sites. (15716243)
2005
17
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. (15958859)
2005
18
An indolent case of T-prolymphocytic leukemia with t(3;22)(q21;q11.2) and elevated serum beta2-microglobulin. (16119992)
2005
19
T- cell prolymphocytic leukemia - a rare case. (16141512)
2005
20
Development of malignant mesothelioma during treatment for prolymphocytic leukemia: is asbestos or simian virus 40 a link? (15816607)
2005
21
Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia. (15066324)
2004
22
Complex karyotype in one patient with small cell variant of T-prolymphocytic leukemia. Analysis by G-banding and comparative genomic hybridization. (11255284)
2001
23
Application of cross-species color banding (RxFISH) in the study of T-prolymphocytic leukemia. (10870117)
2000
24
Unusual breakpoint distribution of 8p abnormalities in T-prolymphocytic leukemia: a study with YACS mapping to 8p11-p12. (11063795)
2000
25
Recurrent molecular deletion of the 12p13 region, centromeric to ETV6/TEL, in T-cell prolymphocytic leukemia. (11920168)
2000
26
Improvement of quality of life after splenectomy in an HTLV-I carrier with T-cell prolymphocytic leukemia. (10609799)
1999
27
T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23). (10347553)
1999
28
B-cell prolymphocytic leukemia: a survey of 35 patients emphasizing heterogeneity, prognostic factors and evidence for a group with an indolent course. (10194135)
1999
29
Treatment of prolymphocytic leukemia with cladribine. (9540763)
1998
30
Abnormalities of the short arm of chromosome 12 in T cell prolymphocytic leukemia. (9639428)
1998
31
Treatment of T prolymphocytic leukemia with allogeneic bone marrow transplantation. (9580345)
1998
32
Abnormalities of chromosomes 8, 11, 14, and X in T-prolymphocytic leukemia studied by fluorescence in situ hybridization. (9614908)
1998
33
Complete remission in T-cell prolymphocytic leukemia with 2-chlorodeoxyadenosine. (7738636)
1995
34
Overexpression of the PRAD1 oncogene in a patient with prolymphocytic leukemia with t(11;14)(q13;q32). (7497446)
1995
35
Leukemic B-cell colony formation in patients with B-cell prolymphocytic leukemia]. (8479081)
1993
36
Three new monoclonal antibodies that define a unique antigen associated with prolymphocytic leukemia/non-Hodgkin's lymphoma and are effectively internalized after binding to the cell surface antigen. (8417805)
1993
37
Expression of immunoglobulin heavy chain variable gene (VH) in B-chronic lymphocytic leukemia (B-CLL) and B-prolymphocytic leukemia (B-PLL) cell lines. "Restricted" usage of VH3 family. (1318012)
1992
38
Efficacy of fludarabine, a new adenine nucleoside analogue, in patients with prolymphocytic leukemia and the prolymphocytoid variant of chronic lymphocytic leukemia. (1996592)
1991
39
Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T-prolymphocytic leukemia and T-cell leukemias in patients with ataxia telangiectasia. (1913594)
1991
40
Differential response of malignant human B-cells to anti-IgM immunoglobulin (anti-mu) and B-cell growth factor: unique direct cytotoxicity of anti-mu on prolymphocytic leukemia cells. (2119832)
1990
41
Analysis of T-cell-derived factors with the use of B-prolymphocytic leukemia cells. (3257174)
1988
42
B prolymphocytic leukemia cell lines: phenotype and response to B cell differentiation factor. (3259689)
1988
43
Fulminant leukemic polyradiculoneuropathy in a case of B-cell prolymphocytic leukemia. A clinicopathologic report. (3040217)
1987
44
Interleukin-2 can induce proliferation of leukemic B-cells in prolymphocytic leukemia. (3297775)
1987
45
An acquired Robertsonian translocation in prolymphocytic leukemia: a case presentation and review. (3470118)
1987
46
A new anthracycline regimen for prolymphocytic leukemia? Study of a case report with flow cytometric implications. (3479665)
1987
47
Six new cases of prolymphocytic leukemia with heterogeneous prognosis. Clinical and immunologic features, light microscopy, and ultrastructural findings. (3857957)
1985
48
Prolymphocytic leukemia: histologic findings in atypical cases. (6592135)
1984
49
Prolymphocytic leukemia with IgM hypogammaglobulinemia. (6603786)
1983
50
T-cell prolymphocytic leukemia with a suppressor phenotype. (6223570)
1983

Variations for Prolymphocytic Leukemia

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Expression for genes affiliated with Prolymphocytic Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prolymphocytic Leukemia

Search GEO for disease gene expression data for Prolymphocytic Leukemia.

Pathways for genes affiliated with Prolymphocytic Leukemia

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 5Cell Signaling Technology, 60Thomson Reuters
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Pathways related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD38, CD19
2
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.2ZAP70, CD19
39.2ZAP70, CD19
49.2CD19, ZAP70
59.2CD19, ZAP70
69.1ATM, ZAP70
78.7ZAP70, CD5, CD19
88.5CD38, CD5, MS4A1, CD19

Compounds for genes affiliated with Prolymphocytic Leukemia

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1ricin459.6CD19, CD5
2paraffin459.0ATM, MS4A1, CD5
3cyclophosphamide45 51 1110.9ZAP70, MS4A1
4fludarabine45 51 1110.9CD38, ZAP70, MS4A1
5rituximab45 51 1110.8CD38, ZAP70, MS4A1
6atp45 299.5CD38, ZAP70, ATM
7adp45 29 2410.4CD38, ZAP70, ATM
8phosphatidylinositol458.2ATM, ZAP70, CD19, CD38
9lipid457.8ATM, MS4A1, ZAP70, CD19, CD38
10calcium45 51 24 1110.7MS4A1, ZAP70, CD5, CD19, CD38
11tyrosine457.7CD38, CD19, CD5, ZAP70, ATM

GO Terms for genes affiliated with Prolymphocytic Leukemia

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16Gene Ontology
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Cellular components related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.1CD19, CD5, MS4A1
2external side of plasma membraneGO:0098978.8CD19, CD5, MS4A1

Biological processes related to Prolymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell receptor signaling pathwayGO:0508539.4CD38, CD19
2apoptotic signaling pathwayGO:0971909.2CD38, CD5
3protein autophosphorylationGO:0467779.1ZAP70, ATM
4response to hypoxiaGO:0016669.0CD38, ATM

Products for genes affiliated with Prolymphocytic Leukemia

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  • Antibodies
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Sources for Prolymphocytic Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet