MCID: PRS039
MIFTS: 43

Prostate Adenocarcinoma malady

Cancer diseases category
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Summaries for Prostate Adenocarcinoma

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Prostate cancer also known as carcinoma of the prostate is when cancer develops in the prostate, a gland... more...

MalaCards: Prostate Adenocarcinoma, also known as adenocarcinoma of prostate, is related to adenocarcinoma and prostate cancer. An important gene associated with Prostate Adenocarcinoma is MSMB (microseminoprotein, beta-), and among its related pathways are Arachidonic acid metabolism and Eicosanoid Synthesis. The compounds 15(S)-HPETE and 13-L-Hydroperoxylinoleic acid have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node.

Aliases & Classifications for Prostate Adenocarcinoma

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Sources:
8Disease Ontology, 47OMIM, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

prostate adenocarcinoma 8 47
adenocarcinoma of prostate 8 62


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Disease Ontology8 DOID:2526
SNOMED-CT58 399490008
NCIt40 C2919

Related Diseases for Prostate Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Prostate Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.0GRPR, ALOX15B, UPK3A, FOLH1, MSMB
2prostate cancer30.2GRPR, ALOX15, ALOX15B, FOLH1, MSMB
3prostatitis11.4
4adenoma10.4
5endotheliitis10.4
6mucinous adenocarcinoma10.4
7nephrogenic adenoma10.4
8papillary adenocarcinoma10.3
9lymphoepithelioma-like acinar prostate adenocarcinoma10.3
10choroiditis10.3
11myeloma10.3
12retinoblastoma10.3
13transitional cell carcinoma10.3
14priapism10.2
15cushing's syndrome10.2
16small cell carcinoma10.2
17bladder carcinoma10.2
18cervicitis10.2
19herpes simplex10.2
20liposarcoma10.2
21meningioma10.2
22multiple myeloma10.2
23papilloma10.2
24cerebellar degeneration10.2
25chylous ascites10.2
26malakoplakia10.2
27signet ring cell adenocarcinoma10.1
28neuromyelitis optica10.0
29prostate small cell carcinoma10.0
30neuroendocrine carcinoma10.0
31cystadenoma10.0
32pituitary apoplexy10.0
33diabetes insipidus10.0
34colorectal adenocarcinoma10.0
35nephrogenic adenoma of the urethra10.0
36gastrointestinal stromal tumor10.0
37inflammatory breast carcinoma10.0
38anal canal carcinoma10.0
39bullous pemphigoid10.0
40adenomatoid tumor10.0
41hypokalemia10.0
42osteonecrosis10.0
43fibrous histiocytoma10.0
44prostate colloid adenocarcinoma10.0
45prostate signet ring cell adenocarcinoma10.0
46sertoli cell tumor10.0
47pleomorphic liposarcoma10.0
48bladder transitional cell carcinoma10.0
49breast adenocarcinoma10.0
50gingivitis10.0

Graphical network of the top 20 diseases related to Prostate Adenocarcinoma:



Diseases related to prostate adenocarcinoma

Symptoms for Prostate Adenocarcinoma

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Drugs & Therapeutics for Prostate Adenocarcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Prostate Adenocarcinoma

Search NIH Clinical Center for Prostate Adenocarcinoma

Genetic Tests for Prostate Adenocarcinoma

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Anatomical Context for Prostate Adenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Prostate Adenocarcinoma:

33
Prostate, Bone, Lymph node, Endothelial, Lung, Skin, Breast, Spinal cord, Bone marrow, Pituitary, Brain, T cells, Monocytes, Liver, Testes, Myeloid, Testis, Colon, Kidney, Cervix

Animal Models for Prostate Adenocarcinoma or affiliated genes

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Publications for Prostate Adenocarcinoma

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52PubMed
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Articles related to Prostate Adenocarcinoma:

(show top 50)    (show all 678)
idTitleAuthorsYear
1
Penile nodule with inguinal lymphadenopathy: Prostatic adenocarcinoma masquerading as penile cancer. (23671367)
2013
2
Lymphangitic pulmonary metastases in castrate-resistant prostate adenocarcinoma. (22924050)
2012
3
Metastatic prostate adenocarcinoma presenting central diabetes insipidus. (22474455)
2012
4
PSA nadir of <0.5 ng/mL following brachytherapy for early-stage prostate adenocarcinoma is associated with freedom from prostate-specific antigen failure. (21985944)
2012
5
Low dose of ketoconazole in patients with prostate adenocarcinoma resistant to pharmacological castration. (21929520)
2011
6
Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. (20596804)
2011
7
Metastatic prostate adenocarcinoma invading an atypical meningioma. (22000836)
2011
8
Prostate adenocarcinoma with orbital metastasis in an HIV+ man. (21504657)
2011
9
Toxicity report of once weekly radiation therapy for low-risk prostate adenocarcinoma: preliminary results of a phase I/II trial. (21906281)
2011
10
Efficacy and safety of docetaxel plus prednisolone chemotherapy for metastatic hormone-refractory prostate adenocarcinoma: single institutional study in Korea. (20369046)
2010
11
Distal seminal vesicle invasion by prostate adenocarcinoma does not occur in isolation of proximal seminal vesicle invasion or lymphovascular infiltration. (20438404)
2010
12
Histological patterns and associated PSA levels for prostatic adenocarcinoma following brachytherapy. (19646822)
2009
13
Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma. (17639508)
2007
14
Histopathological changes induced by therapies in the benign prostate and prostate adenocarcinoma. (17128417)
2007
15
Hypermethylation of CpG island loci and hypomethylation of LINE-1 and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features. (17139617)
2007
16
Phase II trial of hypofractionated image-guided intensity-modulated radiotherapy for localized prostate adenocarcinoma. (17606331)
2007
17
Single small focus of prostate adenocarcinoma (< or = 1 mm and too small for grading) and clinical significant disease after radical prostatectomy. (16929604)
2006
18
Comparative in vitro and in vivo evaluation of two 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma. (16631086)
2006
19
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. (16357178)
2005
20
15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. (15850718)
2005
21
Number and location of nucleoli and presence of apoptotic bodies in diagnostically challenging cases of prostate adenocarcinoma on needle biopsy. (16260270)
2005
22
A decrease in 1H nuclear magnetic resonance spectroscopically determined citrate in human seminal fluid accompanies the development of prostate adenocarcinoma. (15643195)
2005
23
Clinical understaging in patients with prostate adenocarcinoma submitted to radical prostatectomy: predictive value of serum chromogranin A. (14968443)
2004
24
microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts. (15299066)
2004
25
Characterization of initiation of angiogenesis in early stages of prostate adenocarcinoma development and progression in a transgenic murine model. (15596214)
2004
26
Cystic solitary intracerebral metastasis from prostate adenocarcinoma. (11326565)
2001
27
PSA kinetics after external beam radiotherapy alone or combined with an iridium brachytherapy boost to deliver 85 grays to prostatic adenocarcinoma. (11233840)
2001
28
Prostatic adenocarcinoma with neuroendocrine differentiation of the small cell type]. (11474882)
2001
29
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)
2001
30
Comparison of positivity frequency of bcl-2 expression in prostate adenocarcinoma with low and high Gleason score. (11500787)
2001
31
Prostatic adenocarcinoma metastatic to the breasts: report of a case with diagnosis by fine needle aspiration biopsy. (10754179)
2000
32
Treatment of metastatic hormone-refractory prostate adenocarcinoma (MatLyLu) in Copenhagen rats with micro-osmotic interleukin-2 pumps. (11205294)
2000
33
Effects of N-(4-hydroxyphenyl) retinamide on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in prostate adenocarcinoma cell lines. (10824459)
2000
34
Whole genome amplification and molecular genetic analysis of DNA from paraffin-embedded prostate adenocarcinoma tumor tissue. (10492247)
1999
35
Prostate adenocarcinoma presenting as a solitary choroidal metastasis. (9740957)
1998
36
Prostate-specific membrane antigen expression is greatest in prostate adenocarcinoma and lymph node metastases. (9763084)
1998
37
Apoptosis in prostatic adenocarcinomas; a study of relationship to Ki-67 and Bcl-2 protein expression. (9615774)
1998
38
Vitamin D inhibition of prostate adenocarcinoma growth and metastasis in the Dunning rat prostate model system. (9426741)
1997
39
Case report. Two contrasting radiological presentations of prostatic adenocarcinoma in the jaws. (9161183)
1996
40
Sorting of heparan sulfate proteoglycan into matrix compartments of prostate adenocarcinoma cells. (7830405)
1995
41
Normal range prostate-specific antigen versus age-specific prostate-specific antigen in screening prostate adenocarcinoma. (7542822)
1995
42
DNA ploidy, serum prostate specific antigen, histological grade and immunohistochemistry as predictive parameters of lymph node metastases in T1-T3/M0 prostatic adenocarcinoma. (7531589)
1995
43
Ploidy status correlates with outcome in stage B prostate adenocarcinoma. (8173528)
1994
44
Natural course of clinically localized prostate adenocarcinoma in men less than 70 years old. (2056609)
1991
45
Cutaneous metastasis originating from prostate adenocarcinoma. (2066195)
1991
46
Chylous ascites as a presenting sign of prostatic adenocarcinoma. (2077299)
1990
47
The relation of prostatic acid phosphatase and prostate specific antigen with tumour grade in prostatic adenocarcinoma: an immunohistochemical study. (1699237)
1990
48
The relationship of natural killer cells to metastasis of a transplantable prostate adenocarcinoma. (2417216)
1985
49
Unusual metastatic patterns of prostate adenocarcinoma. (6195357)
1983
50
Metastasis of rat prostate adenocarcinoma cells. (6798581)
1981

Variations for Prostate Adenocarcinoma

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Expression for genes affiliated with Prostate Adenocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Adenocarcinoma

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Pathways for genes affiliated with Prostate Adenocarcinoma

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Sources:
50PathCards, 55Reactome, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 51PharmGKB
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Pathways related to Prostate Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6ALOX15, ALOX15B
2
Show member pathways
aspirin triggered resolvin E biosynthesis38
9.6ALOX15, ALOX15B

Compounds for genes affiliated with Prostate Adenocarcinoma

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24HMDB, 45Novoseek
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Compounds related to Prostate Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
115(S)-HPETE249.6ALOX15, ALOX15B
213-L-Hydroperoxylinoleic acid249.5ALOX15, ALOX15B
315-hydroxyeicosatetraenoic acid459.3ALOX15, ALOX15B

GO Terms for genes affiliated with Prostate Adenocarcinoma

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16Gene Ontology
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Cellular components related to Prostate Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:0160209.0ALOX15, ALOX15B, FOLH1, DCXR

Biological processes related to Prostate Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1arachidonic acid metabolic processGO:0193699.6ALOX15, ALOX15B
2hepoxilin biosynthetic processGO:0511229.5ALOX15, ALOX15B
3lipoxygenase pathwayGO:0193729.3ALOX15, ALOX15B

Molecular functions related to Prostate Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1arachidonate 15-lipoxygenase activityGO:0504739.6ALOX15, ALOX15B

Products for genes affiliated with Prostate Adenocarcinoma

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Sources for Prostate Adenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet