Prostate Calculus

Categories: Reproductive diseases

Aliases & Classifications for Prostate Calculus

MalaCards integrated aliases for Prostate Calculus:

Name: Prostate Calculus 12 14
Calculus of Prostate 12 69
Prostatic Lithiasis 12
Stone of Prostate 12
Prostatic Stone 12


External Ids:

Disease Ontology 12 DOID:13689
ICD10 33 N42.0
ICD9CM 35 602.0
NCIt 47 C26936
UMLS 69 C0149525

Summaries for Prostate Calculus

MalaCards based summary : Prostate Calculus, also known as calculus of prostate, is related to alkaptonuria and azoospermia. An important gene associated with Prostate Calculus is HPD (4-Hydroxyphenylpyruvate Dioxygenase), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Integrated Breast Cancer Pathway. The drugs Aceclofenac and Alfuzosin have been mentioned in the context of this disorder. Affiliated tissues include prostate and kidney, and related phenotypes are Decreased caspase 3/7 activity and renal/urinary system

Related Diseases for Prostate Calculus

Diseases related to Prostate Calculus via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 alkaptonuria 11.4
2 azoospermia 9.9 HGD HPD
3 dowling-degos disease 4 9.8 HGD HPD
4 bladder disease 9.7
5 neurogenic bladder 9.7
6 prostatitis 9.7
7 bardet-biedl syndrome 9.4 AR CASP3
8 medullomyoblastoma 9.1 AR CASP3
9 proliferative fasciitis 8.8 AR C1orf210 HGD HPD
10 vaginal squamous papilloma 8.0 AR C1orf210 CASP3 HGD HPD

Comorbidity relations with Prostate Calculus via Phenotypic Disease Network (PDN):

Bladder Neck Obstruction Prostate Cancer
Prostatic Hypertrophy Prostatitis
Urethral Stricture Urinary Tract Obstruction

Graphical network of the top 20 diseases related to Prostate Calculus:

Diseases related to Prostate Calculus

Symptoms & Phenotypes for Prostate Calculus

GenomeRNAi Phenotypes related to Prostate Calculus according to GeneCards Suite gene sharing:

id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 AR CASP3 HGD

MGI Mouse Phenotypes related to Prostate Calculus:

id Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 AR CASP3 HGD HPD

Drugs & Therapeutics for Prostate Calculus

Drugs for Prostate Calculus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Aceclofenac Approved Phase 3 89796-99-6
Alfuzosin Approved, Investigational Phase 3 81403-80-7 2092
3 Naftopidil Investigational Phase 3 57149-07-2
4 Adrenergic Agents Phase 3
5 Adrenergic alpha-Antagonists Phase 3
6 Adrenergic Antagonists Phase 3
7 Analgesics Phase 3
8 Analgesics, Non-Narcotic Phase 3
9 Antihypertensive Agents Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Anti-Inflammatory Agents, Non-Steroidal Phase 3
12 Antirheumatic Agents Phase 3
13 calcium channel blockers Phase 3
14 Calcium, Dietary Phase 3
15 Neurotransmitter Agents Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Platelet Aggregation Inhibitors Phase 3
18 Adrenergic alpha-1 Receptor Antagonists Phase 3
Tamsulosin Approved, Investigational 106133-20-4 129211
20 Pharmaceutical Solutions
21 Anesthetics

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 Use of a Ureteral Access Sheath During Ureteroscopy and Its Effect on Stone Free Rate Terminated NCT00199524 Phase 4
2 The Effect of Naftopidil for the Double-J Stent Discomfort Completed NCT01959074 Phase 3 Naftopidil;Placebo for Naftopidil;Standard treatment
3 ALF-STONE: Alfuzosin in Uretheric Stones Terminated NCT00454402 Phase 3 Alfuzosin
4 Aqueduct Irrigation System Clinical Protocol: Medical Device Investigational Plan Unknown status NCT02496442
5 Effect of Tamsulosin on Stone Expulsion and Pain Resolution in ED Patients With Ureterolithiasis Completed NCT00762424 Flowmax;placebo
6 Configuration of a New Prostate Disease Nomogram Predicting Prostate Biopsy Outcome Completed NCT01826617
7 Registry and Database Lap Prostatectomy Completed NCT00169676
8 Randomized Controlled Trial Comparing Two Different Morcellators for HoLEP Procedures Completed NCT02195622
9 Exercising Together: An Intervention for Prostate Cancer Survivors and Spouses Completed NCT00954044
10 Postoperative Telerounding: A Multi-Center Prospective Randomized Assessment of Patient Outcomes and Satisfaction. Completed NCT00263107
11 Ultrasound-Guided Photoselective Vaporization of the Prostate Recruiting NCT02346500 Early Phase 1
12 Laser Prostatectomy Database and Registry Recruiting NCT00159406
13 Urine and Stool Analysis in Kidney Stone Disease Recruiting NCT01637506
14 Changes of microRNA Expression in Obstructive and Neurogenic Bladder Dysfunction Recruiting NCT02410876
15 Holmium Laser Ablation of the Prostate (HoLAP) Versus KTP Laser Vaporization of the Prostate Terminated NCT00169767
16 Feasibility Study of Prostate Tumor Localization for Focal Cryoablation of Prostate Carcinoma Terminated NCT00851682
17 Salvage Cryotherapy in Recurrent Prostate Cancer Terminated NCT00824928

Search NIH Clinical Center for Prostate Calculus

Genetic Tests for Prostate Calculus

Anatomical Context for Prostate Calculus

MalaCards organs/tissues related to Prostate Calculus:

Prostate, Kidney

Publications for Prostate Calculus

Articles related to Prostate Calculus:

id Title Authors Year
Giant vesico-prostatic calculus in a patient with neurogenic bladder disease. A case report. ( 4428188 )

Variations for Prostate Calculus

Expression for Prostate Calculus

Search GEO for disease gene expression data for Prostate Calculus.

Pathways for Prostate Calculus

GO Terms for Prostate Calculus

Biological processes related to Prostate Calculus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 L-phenylalanine catabolic process GO:0006559 8.96 HGD HPD
2 tyrosine catabolic process GO:0006572 8.62 HGD HPD

Molecular functions related to Prostate Calculus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dioxygenase activity GO:0051213 8.62 HGD HPD

Sources for Prostate Calculus

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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