MCID: PRS040
MIFTS: 91

Prostate Cancer malady

Cancer diseases category

Summaries for Prostate Cancer

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Sources:
33MedlinePlus, 3CDC, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The prostate is the gland below a man's bladder that produces fluid for semen. prostate cancer is common among older men. it is rare in men younger than 40. risk factors for developing prostate cancer include being over 65 years of age, family history, being african-american, and some genetic changes. symptoms of prostate cancer may include problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling low back pain pain with ejaculation your doctor will diagnose prostate cancer by feeling the prostate through the wall of the rectum or doing a blood test for prostate-specific antigen (psa). other tests include ultrasound, x-rays, or a biopsy. treatment often depends on the stage of the cancer. how fast the cancer grows and how different it is from surrounding tissue helps determine the stage. men with prostate cancer have many treatment options. the treatment that's best for one man may not be best for another. the options include watchful waiting, surgery, radiation therapy, hormone therapy, and chemotherapy. you may have a combination of treatments. nih: national cancer institute

MalaCards: Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and leukemia. An important gene associated with Prostate Cancer is AR (androgen receptor), and among its related pathways are Integrated Breast Cancer Pathway and Glioma. The drugs cisplatin and cisplatin pwdr and the compounds testosterone and serine have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast, and related mouse phenotypes are cellular and reproductive system.

CDC:3 Prostate cancer is the most common cancer among American men. Most prostate cancers grow slowly, and don’t cause any health problems in men who have them.

Novus Biologicals:45 Prostate cancer is the most common non-skin cancer and second most deadly cancer for men in the United States. Prostate cancer occurs when cells within the prostate grow uncontrollably and create small tumors. If untreated, cells from these tumors can spread via metastasis. Metastasis transports prostate cancer cells through the lymphatic system and bloodstream to other parts of the body where they can grow into secondary tumors. PSA, a protein produced by the prostate, is released into the bloodstream in small amounts under normal conditions. However, PSA is released in increasing amounts when the prostate is malfunctioning, as is the case with prostate cancer.

Wikipedia:63 Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive... more...

Description from OMIM:46 176807

Aliases & Classifications for Prostate Cancer

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8Disease Ontology, 9diseasecard, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

prostate cancer 8 9 46 10 44 33 30
prostate carcinoma 8 44 60
malignant tumor of prostate 8 22
carcinoma of prostate 8 20
malignant tumor of the prostate 8
malignant neoplasm of prostate 60
ngp - new growth of prostate 8
tumor of the prostate 8
neoplasm of prostate 8
malignant neoplasms 60
prostatic neoplasms 60
cancer of prostate 8
prostatic neoplasm 8
prostate neoplasm 8
prostatic cancer 8


Related Diseases for Prostate Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Prostate Cancer family:

Prostate Carcinoma in Situ Familial Prostate Cancer
Prostate Cancer 1 Prostate Cancer 4
Prostate Cancer 3

Diseases related to Prostate Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 851)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.5KLK15, BRCA2, AR, CHEK2, CDH1, CD82
2leukemia30.9BRCA2, CHEK2, CD82, RNASEL, MXI1
3adenocarcinoma30.9BRCA2, AR, CHEK2, CDH1, CD82, MXI1
4lung cancer30.8PTEN, CDH1
5colorectal cancer30.7BRCA2, CHEK2, CDH1, CD82, EPHB2, PTEN
6gynecomastia30.7BRCA2, AR, SRD5A2
7ovarian cancer30.7BRCA2, AR, CHEK2, CDH1, EPHB2, RNASEL
8retinoblastoma30.7BRCA2, AR, CHEK2
9male breast cancer30.6BRCA2, AR
10colon cancer30.6BRCA2, CHEK2, CDH1, CD82, EPHB2, PTEN
11adenoma30.5EPHB2, CD82, CDH1
12breast-ovarian cancer, familial, 230.3BRCA2
13pancreatic cancer30.2BRCA2, CDH1, CD82
14bilateral breast cancer30.2CHEK2, BRCA2
15pancreatitis30.2BRCA2
16endometrial carcinoma30.1BRCA2, AR, CDH1, PTEN
17myeloid leukemia30.1MXI1
18bladder carcinoma30.1CD82, CDH1
19androgenic alopecia30.1AR, SRD5A2
20meningioma30.1PTEN
21stomach cancer29.9BRCA2, CHEK2, CDH1, CD82, EPHB2, ZFHX3
22hepatocellular carcinoma29.9BRCA2, AR, CDH1, CD82, SRD5A2, PTEN
23esophageal cancer29.8CDH1
24cervical cancer29.8CD82
25hepatitis c29.8RNASEL
26ductal carcinoma in situ29.8CDH1, BRCA2
27familial colorectal cancer29.8PTEN, BRCA2
28prostatitis11.9
29prostate disease11.0
30vascular cancer10.9
31cell type cancer10.9
32lymph node cancer10.8
33prostatic hypertrophy10.6
34prostate adenocarcinoma10.6
35nasopharynx carcinoma10.6
36obesity10.6
37lip cancer10.6
38pituitary cancer10.5
39proctitis10.5
40hypopharynx cancer10.5
41oropharynx cancer10.5
42osteoporosis10.5
43oral cavity cancer10.5
44familial prostate cancer10.5
45chronic fatigue syndrome10.4
46in situ carcinoma10.4
47neuronitis10.4
48hypogonadism10.4
49testicular cancer10.4
50kaposi's sarcoma10.4

Graphical network of the top 20 diseases related to Prostate Cancer:



Diseases related to prostate cancer

Clinical Features for Prostate Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

176807

Clinical synopsis from OMIM:

176807

Drugs & Therapeutics for Prostate Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Genetic Tests for Prostate Cancer

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20GeneTests, 22GTR
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Genetic tests related to Prostate Cancer:

id Genetic test Affiliating Genes
1 Prostate Cancer20 SRD5A2
2 Malignant Tumor of Prostate22

Anatomical Context for Prostate Cancer

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32MalaCards
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MalaCards organs/tissues related to Prostate Cancer:

32
Prostate, Bone, Breast, Endothelial, Lymph node, Testes, Lung, Skin, T cells, Bone marrow, Colon, Pituitary, Liver, Testis, Kidney, Monocytes, Brain, Heart, Spinal cord, B cells, Myeloid, Nk cells, Cervix, Adipocyte, Thyroid, Placenta, Ovary, Pancreas, Salivary gland, Whole blood, Tongue, Pineal

Animal Models for Prostate Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Prostate Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.7AR, SYT7, CHEK2, CDH1, EPHB2, RNASEL
2MP:000538912.4PTEN, BRCA2, SYT7, CDH1, EPHB2, ZFHX3
3MP:000200612.1BRCA2, AR, CHEK2, CDH1, ZFHX3, MXI1
4MP:000537911.2BRCA2, ZFHX3, MXI1, SRD5A2

Publications for Prostate Cancer

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Sources:
50PubMed
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Articles related to Prostate Cancer:

(show top 50)    (show all 11229)
idTitleAuthorsYear
1
Role of multiparametric magnetic resonance imaging in the diagnosis of prostate cancer. (24430169)
2014
2
Metformin in Chemotherapy-naive Castration-resistant Prostate Cancer: A Multicenter Phase 2 Trial (SAKK 08/09). (24412228)
2014
3
Sensorimotor polyneuropathy and foot-drop as result of a prostate cancer paraneoplastic syndrome. (24400247)
2013
4
Acute radiation-induced nocturia in prostate cancer patients is associated with pretreatment symptoms, radical prostatectomy, and genetic markers in the TGFI^1 gene. (22658438)
2013
5
Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer. (22864661)
2012
6
Runx2 regulates survivin expression in prostate cancer cells. (19949374)
2010
7
ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. (20010854)
2010
8
SRD5A2 V89L polymorphism and prostate cancer risk: a meta-analysis. (19760631)
2010
9
Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. (19825806)
2009
10
A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer. (19267349)
2009
11
Shorter CAG repeats in androgen receptor and non-GG genotypes in prostate-specific antigen loci are associated with decreased risk of benign prostatic hyperplasia and prostate cancer. (18495332)
2008
12
Effects of Eg5 knockdown on human prostate cancer xenograft growth and chemosensitivity. (18512732)
2008
13
Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells. (18281494)
2008
14
Docetaxel, with or without estramustine phosphate, as first-line chemotherapy for hormone-refractory prostate cancer: results of a multicentre, randomized phase II trial. (18485028)
2008
15
The intercellular adhesion molecule, cadherin-10, is a marker for human prostate luminal epithelial cells that is not expressed in prostate cancer. (18084254)
2008
16
The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. (19087307)
2008
17
IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. (17597108)
2007
18
The role of Src in prostate cancer. (17426060)
2007
19
Effect of obese and lean Zucker rat sera on human and rat prostate cancer cells: implications in obesity-related prostate tumor biology. (17270657)
2007
20
Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer. (16353249)
2006
21
1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells. (16883603)
2006
22
Novel mutations of epidermal growth factor receptor in localized prostate cancer. (16720329)
2006
23
The relationship of ultrasensitive measurements of prostate-specific antigen levels to prostate cancer recurrence after radical prostatectomy. (16925750)
2006
24
Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells. (16707595)
2006
25
Antiandrogen-like actions of an antioxidant on survivin, Bcl-2 and PSA in human prostate cancer cells. (16139439)
2005
26
A potential novel marker for human prostate cancer: voltage-gated sodium channel expression in vivo. (16088330)
2005
27
The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype. (15958594)
2005
28
Exploratory study of drug plasma levels during bicalutamide 150 mg therapy co-administered with tamoxifen or anastrozole for prophylaxis of gynecomastia and breast pain in men with prostate cancer. (15838655)
2005
29
Insulin-like growth factor binding protein 2: an androgen-dependent predictor of prostate cancer survival. (15826765)
2005
30
Antagonists of growth hormone releasing hormone (GHRH) and of bombesin/gastrin releasing peptide (BN/GRP) suppress the expression of VEGF, bFGF, and receptors of the EGF/HER family in PC-3 and DU-145 human androgen-independent prostate cancers. (15754342)
2005
31
Methylation of multiple genes in prostate cancer and the relationship with clinicopathological features of disease. (15289848)
2004
32
Osteoblast-derived factors induce androgen-independent proliferation and expression of prostate-specific antigen in human prostate cancer cells. (15014041)
2004
33
Carbohydrate structure and differential binding of prostate specific antigen to Maackia amurensis lectin between prostate cancer and benign prostate hypertrophy. (15044396)
2004
34
Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells. (15256534)
2004
35
Endothelin inhibition: novel therapy for prostate cancer. (14610413)
2003
36
Significance of vitamin D receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in Japanese. (12053022)
2002
37
A novel anti-proliferative property of clusterin in prostate cancer cells. (12409141)
2002
38
PSA doubling time as a predictor of clinical progression after biochemical failure following radical prostatectomy for prostate cancer. (11393495)
2001
39
Apoptosis induction in prostate cancer cells by a novel gene product, pHyde, involves caspase-3. (11593405)
2001
40
Serum-to-urinary prostate-specific antigen ratio in patients with benign prostatic hyperplasia and prostate cancer. (11326656)
2000
41
Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta12,14-prostaglandin J2. (10672903)
2000
42
The relationship between prostate cancer and multi-estimating results of prostate-specific antigen]. (11798836)
2000
43
Prostate cancer associated with CYP17 genotype. (10591544)
1999
44
Review of phase II hormone refractory prostate cancer trials. (10606280)
1999
45
Metastasis-related genes in prostate cancer: the role of caveolin-1. (10453288)
1998-1999
46
Osteoblast-derived survival factors protect PC-3 human prostate cancer cells from adriamycin apoptosis. (9697810)
1998
47
Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells. (9622078)
1998
48
Overexpression of transforming growth factor (TGF) beta1 type II receptor restores TGF-beta1 sensitivity and signaling in human prostate cancer cells. (9486855)
1998
49
External beam radiotherapy versus radical prostatectomy for clinical stage T1-2 prostate cancer: therapeutic implications of stratification by pretreatment PSA levels and biopsy Gleason scores. (9099457)
1997
50
Partial growth suppression of human prostate cancer cells by the Krev-1 suppressor gene. (8084835)
1994

Genetic Variations for Prostate Cancer

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Prostate Cancer:

62 (show all 21)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg181CysVAR_019104rs137853010
3CHEK2p.Arg181HisVAR_019105rs121908701
4CHEK2p.Glu239LysVAR_019106
5CHEK2p.Glu64LysVAR_019107
6CHEK2p.Arg145ProVAR_019108
7CHEK2p.Gly167ArgVAR_019109
8CHEK2p.Arg180HisVAR_019110rs137853009
9CHEK2p.Ile251PheVAR_019111
10CHEK2p.Arg318HisVAR_019112rs143611747
11CHEK2p.Thr323ProVAR_019113
12CHEK2p.Tyr327CysVAR_019114
13CHEK2p.Thr476LysVAR_019115
14EPHB2p.Arg199HisVAR_032853
15EPHB2p.Ala279SerVAR_032854rs35882952
16EPHB2p.Val650AlaVAR_032855rs142173175
17EPHB2p.His679AsnVAR_032856
18EPHB2p.Met883ValVAR_032857
19EPHB2p.Ile909MetVAR_032858
20MXI1p.Glu152AlaVAR_004499
21PTENp.Met134LeuVAR_007469

Expression for genes affiliated with Prostate Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Cancer

Search GEO for disease gene expression data for Prostate Cancer.

Pathways for genes affiliated with Prostate Cancer

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Prostate Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.7PTEN, CDH1, CHEK2, AR, BRCA2
2
Hide members
11.7BRCA2, AR, CDH1, SRD5A2, PTEN
311.7BRCA2, AR, CHEK2, CD82, PTEN
411.5PTEN, CDH1, AR, BRCA2
5
Hide members
11.2PTEN, CHEK2, AR
6
Transcription Androgen Receptor nuclear signaling
Hide members
11.2AR, SRD5A2, PTEN
7
Hide members
11.2PTEN, CD82, CHEK2

Compounds for genes affiliated with Prostate Cancer

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Prostate Cancer according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.5KLK15, BRCA2, AR, CDH1, RNASEL, SRD5A2
2serine4412.4KLK15, AR, CHEK2, CDH1, EPHB2, PTEN
3arginine4412.2AR, CDH1, EPHB2, RNASEL, SRD5A2, PTEN
4retinoic acid44 2413.2BRCA2, AR, CHEK2, CDH1, EPHB2, PTEN
5etoposide44 49 59 1115.0BRCA2, AR, CHEK2, CDH1, PTEN
6paraffin4412.0BRCA2, AR, CDH1, CD82, PTEN
7genistein44 28 59 2 11 2417.0BRCA2, AR, CHEK2, CDH1, PTEN
8progesterone44 59 28 11 2415.9BRCA2, AR, CDH1, SRD5A2, PTEN
9indole-3-carbinol4411.8PTEN, CDH1, AR, BRCA2
10adenine44 11 2413.8SRD5A2, RNASEL, CDH1, AR
11tamoxifen44 49 28 1114.7PTEN, CDH1, AR, BRCA2
12vitamin d4411.7PTEN, SRD5A2, CDH1, AR
13rapamycin4411.7AR, CHEK2, CDH1, PTEN
14steroid4411.6KLK15, BRCA2, AR, SRD5A2
15doxorubicin44 49 1113.6PTEN, CDH1, CHEK2, AR
16dutasteride44 1112.2SRD5A2, AR
17troglitazone44 28 59 1114.2AR, CDH1, PTEN
18sodium bisulfite4411.0AR, CDH1
19finasteride44 59 11 2414.0SRD5A2, AR
20docetaxel44 49 59 1113.9AR, CDH1, BRCA2
21adriamycin4410.6CHEK2

GO Terms for genes affiliated with Prostate Cancer

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16Gene Ontology
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Cellular components related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Schmidt-Lanterman incisureGO:04322011.0PTEN, CDH1

Biological processes related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:05077111.0PTEN, EPHB2
2prostate gland growthGO:06073610.9PTEN, AR
3dendritic spine morphogenesisGO:06099710.7PTEN, EPHB2

Products for genes affiliated with Prostate Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostate Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet