MCID: PRS040
MIFTS: 91

Prostate Cancer malady

Cancer diseases category

Summaries for Prostate Cancer

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Sources:
33MedlinePlus, 3CDC, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The prostate is the gland below a man's bladder that produces fluid for semen. prostate cancer is common among older men. it is rare in men younger than 40. risk factors for developing prostate cancer include being over 65 years of age, family history, being african-american, and some genetic changes. symptoms of prostate cancer may include problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling low back pain pain with ejaculation your doctor will diagnose prostate cancer by feeling the prostate through the wall of the rectum or doing a blood test for prostate-specific antigen (psa). other tests include ultrasound, x-rays, or a biopsy. treatment often depends on the stage of the cancer. how fast the cancer grows and how different it is from surrounding tissue helps determine the stage. men with prostate cancer have many treatment options. the treatment that's best for one man may not be best for another. the options include watchful waiting, surgery, radiation therapy, hormone therapy, and chemotherapy. you may have a combination of treatments. nih: national cancer institute

MalaCards: Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and leukemia. An important gene associated with Prostate Cancer is AR (androgen receptor), and among its related pathways are Integrated Breast Cancer Pathway and Glioma. The drugs cisplatin and cisplatin pwdr and the compounds testosterone and serine have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast, and related mouse phenotypes are cellular and reproductive system.

CDC:3 Prostate cancer is the most common cancer among American men. Most prostate cancers grow slowly, and don’t cause any health problems in men who have them.

Novus Biologicals:45 Prostate cancer is the most common non-skin cancer and second most deadly cancer for men in the United States. Prostate cancer occurs when cells within the prostate grow uncontrollably and create small tumors. If untreated, cells from these tumors can spread via metastasis. Metastasis transports prostate cancer cells through the lymphatic system and bloodstream to other parts of the body where they can grow into secondary tumors. PSA, a protein produced by the prostate, is released into the bloodstream in small amounts under normal conditions. However, PSA is released in increasing amounts when the prostate is malfunctioning, as is the case with prostate cancer.

Wikipedia:63 Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive... more...

Description from OMIM:46 176807

Aliases & Classifications for Prostate Cancer

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8Disease Ontology, 9diseasecard, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

prostate cancer 8 9 46 10 44 33 30
prostate carcinoma 8 44 60
malignant tumor of prostate 8 22
carcinoma of prostate 8 20
malignant tumor of the prostate 8
malignant neoplasm of prostate 60
ngp - new growth of prostate 8
tumor of the prostate 8
neoplasm of prostate 8
malignant neoplasms 60
prostatic neoplasms 60
cancer of prostate 8
prostatic neoplasm 8
prostate neoplasm 8
prostatic cancer 8


Related Diseases for Prostate Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Prostate Cancer family:

Prostate Carcinoma in Situ Familial Prostate Cancer
Prostate Cancer 1 Prostate Cancer 4
Prostate Cancer 3

Diseases related to Prostate Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 851)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.5KLK15, BRCA2, AR, CHEK2, CDH1, CD82
2leukemia30.9BRCA2, CHEK2, CD82, RNASEL, MXI1
3adenocarcinoma30.9BRCA2, AR, CHEK2, CDH1, CD82, MXI1
4lung cancer30.8PTEN, CDH1
5colorectal cancer30.7BRCA2, CHEK2, CDH1, CD82, EPHB2, PTEN
6gynecomastia30.7BRCA2, AR, SRD5A2
7ovarian cancer30.7BRCA2, AR, CHEK2, CDH1, EPHB2, RNASEL
8retinoblastoma30.7BRCA2, AR, CHEK2
9male breast cancer30.6BRCA2, AR
10colon cancer30.6BRCA2, CHEK2, CDH1, CD82, EPHB2, PTEN
11adenoma30.5EPHB2, CD82, CDH1
12breast-ovarian cancer, familial, 230.3BRCA2
13pancreatic cancer30.2BRCA2, CDH1, CD82
14bilateral breast cancer30.2CHEK2, BRCA2
15pancreatitis30.2BRCA2
16endometrial carcinoma30.1BRCA2, AR, CDH1, PTEN
17myeloid leukemia30.1MXI1
18bladder carcinoma30.1CD82, CDH1
19androgenic alopecia30.1AR, SRD5A2
20meningioma30.1PTEN
21stomach cancer29.9BRCA2, CHEK2, CDH1, CD82, EPHB2, ZFHX3
22hepatocellular carcinoma29.9BRCA2, AR, CDH1, CD82, SRD5A2, PTEN
23esophageal cancer29.8CDH1
24cervical cancer29.8CD82
25hepatitis c29.8RNASEL
26ductal carcinoma in situ29.8CDH1, BRCA2
27familial colorectal cancer29.8PTEN, BRCA2
28prostatitis11.9
29prostate disease11.0
30vascular cancer10.9
31cell type cancer10.9
32lymph node cancer10.8
33prostatic hypertrophy10.6
34prostate adenocarcinoma10.6
35nasopharynx carcinoma10.6
36obesity10.6
37lip cancer10.6
38pituitary cancer10.5
39proctitis10.5
40hypopharynx cancer10.5
41oropharynx cancer10.5
42osteoporosis10.5
43oral cavity cancer10.5
44familial prostate cancer10.5
45chronic fatigue syndrome10.4
46in situ carcinoma10.4
47neuronitis10.4
48hypogonadism10.4
49testicular cancer10.4
50kaposi's sarcoma10.4

Graphical network of the top 20 diseases related to Prostate Cancer:



Diseases related to prostate cancer

Clinical Features for Prostate Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

176807

Clinical synopsis from OMIM:

176807

Drugs & Therapeutics for Prostate Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Genetic Tests for Prostate Cancer

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Prostate Cancer:

id Genetic test Affiliating Genes
1 Prostate Cancer20 SRD5A2
2 Malignant Tumor of Prostate22

Anatomical Context for Prostate Cancer

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32MalaCards
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MalaCards organs/tissues related to Prostate Cancer:

32
Prostate, Bone, Breast, Endothelial, Lymph node, Testes, Lung, Skin, T cells, Bone marrow, Colon, Pituitary, Liver, Testis, Kidney, Monocytes, Brain, Heart, Spinal cord, B cells, Myeloid, Nk cells, Cervix, Adipocyte, Thyroid, Placenta, Ovary, Pancreas, Salivary gland, Whole blood, Tongue, Pineal

Animal Models for Prostate Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Prostate Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.7AR, SYT7, CHEK2, CDH1, EPHB2, RNASEL
2MP:000538912.4PTEN, BRCA2, SYT7, CDH1, EPHB2, ZFHX3
3MP:000200612.1BRCA2, AR, CHEK2, CDH1, ZFHX3, MXI1
4MP:000537911.2BRCA2, ZFHX3, MXI1, SRD5A2

Publications for Prostate Cancer

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Sources:
50PubMed
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Articles related to Prostate Cancer:

(show top 50)    (show all 11229)
idTitleAuthorsYear
1
Radioiodine therapy for castration-resistant prostate cancer following prostate-specific membrane antigen promoter-mediated transfer of the human sodium iodide symporter. (24369144)
2014
2
A Pilot Study of Potential Pre-Operative Barriers to Couples' Sexual Recovery After Radical Prostatectomy for Prostate Cancer. (24405053)
2013
3
Testosterone deficiency, supplementation, and prostate cancer: maintaining a balanced perspective. (24299509)
2013
4
Interleukin-27 expression modifies prostate cancer cell crosstalk with bone and immune cells in vitro. (23086758)
2013
5
Whole-transcriptome analysis reveals established and novel associations with TMPRSS2:ERG fusion in prostate cancer. (22993300)
2012
6
Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis. (22426141)
2012
7
Meta-analysis of the relation between the VDR gene TaqIpolymorphism and genetic susceptibility to prostate cancer in Asian populations. (23167358)
2012
8
Antitumor activity of NF-kB decoy oligodeoxynucleotides in a prostate cancer cell line. (22320981)
2011
9
Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer. (20852942)
2011
10
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. (21620777)
2011
11
Lactate dehydrogenase, Gleason score and HER-2 overexpression are significant prognostic factors for M1b prostate cancer. (21249322)
2011
12
Are GSTM1, GSTT1 and CAG repeat length of androgen receptor gene polymorphisms associated with risk of prostate cancer in Iranian patients? (21089003)
2011
13
Expression profiling identifies new function of collapsin response mediator protein 4 as a metastasis-suppressor in prostate cancer. (20543870)
2010
14
Analysis of NSAID-activated gene 1 expression in prostate cancer. (20215826)
2010
15
Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells. (19552765)
2009
16
Androgen modulation of coregulator expression in prostate cancer cells. (19164447)
2009
17
Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation. (19026633)
2009
18
Small interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress. (19671688)
2009
19
Serum adipocytokine levels in prostate cancer patients. (19322011)
2009
20
Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling. (19597471)
2009
21
Calcitonin promotes in vivo metastasis of prostate cancer cells by altering cell signaling, adhesion, and inflammatory pathways. (18784182)
2008
22
Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer. (19099590)
2008
23
Gene expression profile of prostate cancer cell lines: effect of nerve growth factor treatment. (18280641)
2008
24
Peroxisome Proliferator-Activated Receptor-gamma Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer. (18317513)
2008
25
Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. (17430995)
2007
26
Androgen induction of the androgen receptor coactivator four and a half LIM domain protein-2: evidence for a role for serum response factor in prostate cancer. (17975004)
2007
27
Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein. (17697368)
2007
28
Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. (16752412)
2006
29
Prediction of the stage of patients with prostate cancer by the combination of serum prostate specific antigen and Gleason score]. (16638345)
2006
30
Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer. (16921512)
2006
31
Alcohol drinking and risk of localized versus advanced and sporadic versus familial prostate cancer in Sweden. (15947879)
2005
32
Immunohistochemical expression of Ki-67 antigen, cox-2 and Bax/Bcl-2 in prostate cancer; prognostic value in biopsies and radical prostatectomy specimens. (16139948)
2005
33
Clinical significance of expression of PSA, hK2, PSMA in the peripheral blood of patients with prostate cancer]. (15555338)
2004
34
Preclinical testing of a peptide-based, HER2/neu vaccine for prostate cancer. (15547716)
2004
35
Somatostatin receptors: from basic science to clinical approach. Unlabeled somatostatin analogues-1: Prostate cancer. (15077913)
2004
36
Matrix metalloproteinase-2 contributes to increased platelet reactivity in patients with metastatic prostate cancer: a preliminary study. (15013275)
2003
37
Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone. (12673556)
2003
38
Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. (11751502)
2001
39
Optimal predictors of prostate cancer on repeat prostate biopsy: a prospective study of 1,051 men. (10737484)
2000
40
Prostate cancer detection in Black and White men with abnormal digital rectal examination and prostate specific antigen less then 4 ng./ml. (11061891)
2000
41
The significance of the free-to-complexed prostate-specific antigen (PSA) ratio in prostate cancer detection in patients with a PSA level of 4.1-10.0 ng/mL. (10759671)
2000
42
Decreased HLA-A expression in prostate cancer is associated with normal allele dosage in the majority of cases. (10657015)
2000
43
Comparative efficiency of prostate-specific antigen screening strategies for prostate cancer detection. (10989402)
2000
44
Insulin-like growth factor-binding protein-3 is partially responsible for high-serum-induced apoptosis in PC-3 prostate cancer cells. (10588822)
1999
45
Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. (10477909)
1999
46
The effects of brefeldin A (BFA) on cell cycle progression involving the modulation of the retinoblastoma protein (pRB) in PC-3 prostate cancer cells. (9400494)
1998
47
Tissue expression of neu differentiation factor/heregulin and its receptor complex in prostate cancer and its biologic effects on prostate cancer cells in vitro. (9072304)
1997
48
Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. (8910276)
1996
49
Usefulness of prostate specific antigen/gamma-seminoprotein ratio for diagnosis of prostate cancer]. (7688442)
1993
50
Production and response of a human prostatic cancer line to transforming growth factor-like molecules. (2223575)
1990

Genetic Variations for Prostate Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Prostate Cancer:

62 (show all 21)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg181CysVAR_019104rs137853010
3CHEK2p.Arg181HisVAR_019105rs121908701
4CHEK2p.Glu239LysVAR_019106
5CHEK2p.Glu64LysVAR_019107
6CHEK2p.Arg145ProVAR_019108
7CHEK2p.Gly167ArgVAR_019109
8CHEK2p.Arg180HisVAR_019110rs137853009
9CHEK2p.Ile251PheVAR_019111
10CHEK2p.Arg318HisVAR_019112rs143611747
11CHEK2p.Thr323ProVAR_019113
12CHEK2p.Tyr327CysVAR_019114
13CHEK2p.Thr476LysVAR_019115
14EPHB2p.Arg199HisVAR_032853
15EPHB2p.Ala279SerVAR_032854rs35882952
16EPHB2p.Val650AlaVAR_032855rs142173175
17EPHB2p.His679AsnVAR_032856
18EPHB2p.Met883ValVAR_032857
19EPHB2p.Ile909MetVAR_032858
20MXI1p.Glu152AlaVAR_004499
21PTENp.Met134LeuVAR_007469

Expression for genes affiliated with Prostate Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Cancer

Search GEO for disease gene expression data for Prostate Cancer.

Pathways for genes affiliated with Prostate Cancer

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Prostate Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.7PTEN, CDH1, CHEK2, AR, BRCA2
2
Hide members
11.7BRCA2, AR, CDH1, SRD5A2, PTEN
311.7BRCA2, AR, CHEK2, CD82, PTEN
411.5PTEN, CDH1, AR, BRCA2
5
Hide members
11.2PTEN, CHEK2, AR
6
Transcription Androgen Receptor nuclear signaling
Hide members
11.2AR, SRD5A2, PTEN
7
Hide members
11.2PTEN, CD82, CHEK2

Compounds for genes affiliated with Prostate Cancer

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Prostate Cancer according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.5KLK15, BRCA2, AR, CDH1, RNASEL, SRD5A2
2serine4412.4KLK15, AR, CHEK2, CDH1, EPHB2, PTEN
3arginine4412.2AR, CDH1, EPHB2, RNASEL, SRD5A2, PTEN
4retinoic acid44 2413.2BRCA2, AR, CHEK2, CDH1, EPHB2, PTEN
5etoposide44 49 59 1115.0BRCA2, AR, CHEK2, CDH1, PTEN
6paraffin4412.0BRCA2, AR, CDH1, CD82, PTEN
7genistein44 28 59 2 11 2417.0BRCA2, AR, CHEK2, CDH1, PTEN
8progesterone44 59 28 11 2415.9BRCA2, AR, CDH1, SRD5A2, PTEN
9indole-3-carbinol4411.8PTEN, CDH1, AR, BRCA2
10adenine44 11 2413.8SRD5A2, RNASEL, CDH1, AR
11tamoxifen44 49 28 1114.7PTEN, CDH1, AR, BRCA2
12vitamin d4411.7PTEN, SRD5A2, CDH1, AR
13rapamycin4411.7AR, CHEK2, CDH1, PTEN
14steroid4411.6KLK15, BRCA2, AR, SRD5A2
15doxorubicin44 49 1113.6PTEN, CDH1, CHEK2, AR
16dutasteride44 1112.2SRD5A2, AR
17troglitazone44 28 59 1114.2AR, CDH1, PTEN
18sodium bisulfite4411.0AR, CDH1
19finasteride44 59 11 2414.0SRD5A2, AR
20docetaxel44 49 59 1113.9AR, CDH1, BRCA2
21adriamycin4410.6CHEK2

GO Terms for genes affiliated with Prostate Cancer

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16Gene Ontology
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Cellular components related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Schmidt-Lanterman incisureGO:04322011.0PTEN, CDH1

Biological processes related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:05077111.0PTEN, EPHB2
2prostate gland growthGO:06073610.9PTEN, AR
3dendritic spine morphogenesisGO:06099710.7PTEN, EPHB2

Products for genes affiliated with Prostate Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostate Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet