MCID: PRS040
MIFTS: 87

Prostate Cancer malady

Genetic diseases, Cancer diseases, Rare diseases categories

Summaries for Prostate Cancer

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Sources:
35MedlinePlus, 4CDC, 47Novus Biologicals, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 The prostate is the gland below a man's bladder that produces fluid for semen. prostate cancer is common among older men. it is rare in men younger than 40. risk factors for developing prostate cancer include being over 65 years of age, family history, being african-american, and some genetic changes. symptoms of prostate cancer may include problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling low back pain pain with ejaculation your doctor will diagnose prostate cancer by feeling the prostate through the wall of the rectum or doing a blood test for prostate-specific antigen (psa). other tests include ultrasound, x-rays, or a biopsy. treatment often depends on the stage of the cancer. how fast the cancer grows and how different it is from surrounding tissue helps determine the stage. men with prostate cancer have many treatment options. the treatment that's best for one man may not be best for another. the options include watchful waiting, surgery, radiation therapy, hormone therapy, and chemotherapy. you may have a combination of treatments. nih: national cancer institute

MalaCards: Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and adenocarcinoma. An important gene associated with Prostate Cancer is AR (androgen receptor), and among its related pathways are Integrated Breast Cancer Pathway and Glioma. The drugs cisplatin and cisplatin pwdr and the compounds testosterone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

CDC:4 Prostate cancer is the most common cancer among American men. Most prostate cancers grow slowly, and donā€™t cause any health problems in men who have them.

Novus Biologicals:47 Prostate cancer is the most common non-skin cancer and second most deadly cancer for men in the United States. Prostate cancer occurs when cells within the prostate grow uncontrollably and create small tumors. If untreated, cells from these tumors can spread via metastasis. Metastasis transports prostate cancer cells through the lymphatic system and bloodstream to other parts of the body where they can grow into secondary tumors. PSA, a protein produced by the prostate, is released into the bloodstream in small amounts under normal conditions. However, PSA is released in increasing amounts when the prostate is malfunctioning, as is the case with prostate cancer.

Wikipedia:66 Prostate cancer also known as carcinoma of the prostate is when cancer develops in the prostate, a gland... more...

Description from OMIM:48 176807

Aliases & Classifications for Prostate Cancer

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9Disease Ontology, 10diseasecard, 21GeneTests, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases


Aliases & Descriptions:

prostate cancer 9 10 48 11 46 35 32
prostate carcinoma 9 46 63
malignant tumor of the prostate 9 23
cancer of prostate 9 21
malignant neoplasm of prostate 63
ngp - new growth of prostate 9
malignant tumor of prostate 9
carcinoma of prostate 9
tumor of the prostate 9
neoplasm of prostate 9
malignant neoplasms 63
prostatic neoplasms 63
prostatic neoplasm 9
prostate neoplasm 9
prostatic cancer 9


Related Diseases for Prostate Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Prostate Cancer family:

Prostate Carcinoma in Situ Familial Prostate Cancer
Prostate Cancer 1 Prostate Cancer, Hereditary, 12
Prostate Cancer, Hereditary, 5 Prostate Cancer 4
Prostate Cancer, Hereditary, 10 Prostate Cancer, Hereditary, 13
Prostate Cancer, Hereditary, 14 Prostate Cancer, Hereditary, 7
Prostate Cancer, Hereditary, 2 Prostate Cancer, Hereditary, 11
Prostate Cancer, Hereditary, 9 Prostate Cancer, Hereditary, 15
Prostate Cancer 3

Diseases related to Prostate Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 326)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2BRCA2, CDH1, AR
2adenocarcinoma31.1CDH1, CD82, CHEK2, PTEN, BRCA2, MXI1
3leukemia31.1CD82, BRCA2, RNASEL, CHEK2, MXI1
4gynecomastia31.0BRCA2, AR, SRD5A2
5melanoma30.7CDH1, CD82, MXI1, BRCA2, CHEK2, PTEN
6male breast cancer30.7BRCA2, AR
7colorectal cancer30.6EPHB2, PTEN, CD82, CDH1, BRCA2, CHEK2
8ovarian cancer30.5RNASEL, BRCA2, AR, CHEK2, EPHB2, SRD5A2
9androgen insensitivity syndrome30.3AR, SRD5A2
10hepatocellular carcinoma30.1CDH1, BRCA2, AR, CD82, SRD5A2, PTEN
11bilateral breast cancer30.1CHEK2, BRCA2
12glioblastoma multiforme30.1EPHB2, PTEN, CHEK2, MXI1
13prostatitis11.9
14endotheliitis11.0
15familial prostate cancer10.9
16hypoxia10.8
17prostatic hypertrophy10.6
18obesity10.6
19prostate disease10.6
20somatostatin analog10.6
21proctitis10.5
22blindness10.5
23osteoporosis10.5
24retinoblastoma10.5
25solitary fibrous tumor10.4
26chronic fatigue syndrome10.4
27neuronitis10.4
28prostate cancer 110.4
29disseminated intravascular coagulation10.4
30hypogonadism10.4
31germ cell tumors10.4
32urethritis10.4
33adenoma10.4
34impotence10.4
35prostate cancer, progression and metastasis of10.4
36alopecia10.3
37prostate cancer 310.3
38radiation proctitis10.3
39benign prostate phyllodes tumor10.3
40endodermal sinus tumor10.3
41primitive neuroectodermal tumor10.3
42extragonadal germ cell tumor10.3
43vaccinia10.3
44herpes simplex10.3
45lynch syndrome10.3
46myeloma10.3
47prostate adenocarcinoma10.3
48pituitary apoplexy10.3
49diabetes mellitus10.3
50hepatitis10.3

Graphical network of the top 20 diseases related to Prostate Cancer:



Diseases related to prostate cancer

Symptoms for Prostate Cancer

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48OMIM
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Symptoms by clinical synopsis from OMIM:

176807

Clinical features from OMIM:

176807

Drugs & Therapeutics for Prostate Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Genetic Tests for Prostate Cancer

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21GeneTests, 23GTR
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Genetic tests related to Prostate Cancer:

id Genetic test Affiliating Genes
1 Prostate Cancer21 SRD5A2
2 Malignant Tumor of Prostate23

Anatomical Context for Prostate Cancer

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34MalaCards
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MalaCards organs/tissues related to Prostate Cancer:

34
Prostate, Bone, Breast, Endothelial, Testes, Lymph node, Skin, T cells, Bone marrow, Lung, Pituitary, Liver, Testis, Colon, Monocytes, Kidney, Brain, Myeloid, B cells, Heart, Adipocyte, Nk cells, Spinal cord, Whole blood, Tongue, Pineal, Cervix, Pancreas, Placenta, Ovary, Salivary gland, Thyroid

Animal Models for Prostate Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Prostate Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200611.0AR, PTEN, ZFHX3, BRCA2, CHEK2, MXI1
2MP:000537911.0PTEN, ZFHX3, BRCA2, EPHB2, SRD5A2, MXI1
3MP:000538910.9PTEN, ZFHX3, BRCA2, EPHB2, SRD5A2, MXI1
4MP:000536710.8AR, MXI1, EPHB2, ZFHX3, PTEN
5MP:000538410.7PTEN, BRCA2, RNASEL, EPHB2, CHEK2, MXI1

Publications for Prostate Cancer

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Sources:
53PubMed
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Articles related to Prostate Cancer:

(show top 50)    (show all 10667)
idTitleAuthorsYear
1
Re: Effect of Soy Protein Isolate Supplementation on Biochemical Recurrence ofA Prostate Cancer after Radical Prostatectomy: A Randomized Trial. (24331479)
2014
2
Lumican expression, localization and antitumor activity in prostate cancer. (23399832)
2013
3
Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. (23676682)
2013
4
Pre-prostatic tissue removed in robotic assisted lymph node dissection for prostate cancer contains lymph nodes. (24311906)
2013
5
Pre-chemotherapy Abiraterone Acetate. A Proposal of a Treatment Algorithm in Castration Resistant Prostate Cancer. (24342031)
2013
6
No evidence of FGFR3 mutations in prostate cancer. (20957671)
2011
7
PPARI^ disease gene network and identification of therapeutic targets for prostate cancer. (21780947)
2011
8
Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. (19820934)
2010
9
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF- kappaB activity in prostate cancer cells. (20068069)
2010
10
CYP17 polymorphisms and prostate cancer outcomes. (20503394)
2010
11
Promising tumor-associated antigens for future prostate cancer therapy. (19536865)
2010
12
Other biomarkers for detecting prostate cancer. (19930175)
2010
13
Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. (18824345)
2009
14
Biopsy tissue microarray study of Ki-67 expression in untreated, localized prostate cancer managed by active surveillance. (18762814)
2009
15
Y chromosome haplotypes and prostate cancer in Sweden. (18927315)
2008
16
A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. (18703514)
2008
17
Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk: a replication study in an ethnically homogeneous population. (18537123)
2008
18
ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel. (18628469)
2008
19
P2Y purinergic receptor activated PI-3K/Akt signaling pathway in regulation of growth and invasion of prostatic cancer]. (18194602)
2007
20
Locally advanced prostate cancer: biochemical results from a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific antigen recurrence after radiotherapy. (17559131)
2007
21
Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer. (16698360)
2006
22
Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer. (16388505)
2006
23
Characterization of frequently deleted 6q locus in prostate cancer. (17132090)
2006
24
Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. (16461912)
2006
25
Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer. (16161052)
2006
26
Targeting stathmin in prostate cancer. (16373697)
2005
27
A novel knock-in prostate cancer model demonstrates biology similar to that of human prostate cancer and suitable for preclinical studies. (15727931)
2005
28
Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. (16005185)
2005
29
An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. (15266311)
2004
30
Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer. (15280008)
2004
31
Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events. (15390081)
2004
32
Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease. (14716676)
2004
33
Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population]. (14574802)
2003
34
A comparative study of prostate specific antigen (PSA), C-terminal propeptide of blood type I procollagen (PICP) and urine type I collagen-crosslinked N telopeptide (NTx) levels using bone scintigraphy in prostate cancer patients. (12932112)
2003
35
Metastatic prostate cancer with normal level of serum prostate-specific antigen. (15072491)
2003
36
A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. (12711671)
2003
37
A phase II Hoosier Oncology Group study of vinorelbine and estramustine phosphate in hormone-refractory prostate cancer. (11996476)
2002
38
Differential activation of the IGF binding protein-3 promoter by butyrate in prostate cancer cells. (11956160)
2002
39
Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells. (12269771)
2002
40
The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. (12239635)
2002
41
Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. (11228105)
2001
42
Endothelin-1 production by prostate cancer cell lines is up-regulated by factors involved in cancer progression and down-regulated by androgens. (11746273)
2001
43
A novel human cancer culture model for the study of prostate cancer. (11753687)
2001
44
Contrasting effects of aspirin on prostate cancer cells: suppression of proliferation and induction of drug resistance . (10639187)
2000
45
BRCA1 and BRCA2 have a limited role in familial prostate cancer. (10728701)
2000
46
Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. (10475365)
1999
47
The combination of human glandular kallikrein and free prostate-specific antigen (PSA) enhances discrimination between prostate cancer and benign prostatic hyperplasia in patients with moderately increased total PSA. (10545066)
1999
48
Clinical pharmacokinetics of the antiandrogens and their efficacy in prostate cancer. (9592622)
1998
49
NGF-beta, NE-cells and prostatic cancer cell lines. A study of neuroendocrine expression in the human prostatic cancer cell lines DU-145, PC-3, LNCaP, and TSU-pr1 following stimulation of the nerve growth factor-beta. (9561567)
1998
50
Free and total serum PSA values in patients with prostatic intraepithelial neoplasia (PIN), prostate cancer and BPH. Is F/T PSA a potential probe for dormant and manifest cancer? (9179191)
1997

Variations for Prostate Cancer

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Prostate Cancer:

65 (show all 21)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg181CysVAR_019104rs137853010
3CHEK2p.Arg181HisVAR_019105rs121908701
4CHEK2p.Glu239LysVAR_019106
5CHEK2p.Glu64LysVAR_019107
6CHEK2p.Arg145ProVAR_019108
7CHEK2p.Gly167ArgVAR_019109
8CHEK2p.Arg180HisVAR_019110rs137853009
9CHEK2p.Ile251PheVAR_019111
10CHEK2p.Arg318HisVAR_019112rs143611747
11CHEK2p.Thr323ProVAR_019113
12CHEK2p.Tyr327CysVAR_019114
13CHEK2p.Thr476LysVAR_019115
14EPHB2p.Arg199HisVAR_032853
15EPHB2p.Ala279SerVAR_032854rs35882952
16EPHB2p.Val650AlaVAR_032855rs142173175
17EPHB2p.His679AsnVAR_032856
18EPHB2p.Met883ValVAR_032857
19EPHB2p.Ile909MetVAR_032858
20MXI1p.Glu152AlaVAR_004499
21PTENp.Met134LeuVAR_007469

Clinvar genetic disease variations for Prostate Cancer:

1 (show all 16)
id Gene Name Type Significance SNP ID Assembly Location
1MSR1NM_138715.2(MSR1): c.877C> T (p.Arg293Ter)single nucleotide variantPathogenicrs41341748GRCh37Chr 8, 16012594: 16012594
2MSR1NM_138715.2(MSR1): c.520G> T (p.Asp174Tyr)single nucleotide variantPathogenicrs72552387GRCh37Chr 8, 16026077: 16026077
3ZFHX3ZFHX3, 24-BP DEL, NT10814deletionPathogenic
4CHEK2NM_007194.3(CHEK2): c.470T> C (p.Ile157Thr)single nucleotide variantLikely pathogenic, Pathogenic, risk factorrs17879961GRCh37Chr 22, 29121087: 29121087
5BRCA2BRCA2, 1-BP DEL, 6051AdeletionPathogenic
6BRCA2BRCA2, 1-BP INS, 2558AinsertionPathogenic
7MXI1MXI1, 1-BP DEL, A, CODON 140 OR 141deletionPathogenic
8MXI1NM_130439.3(MXI1): c.552+2T> Csingle nucleotide variantPathogenicrs387906417GRCh37Chr 10, 112039054: 112039054
9MXI1NM_130439.3(MXI1): c.656A> C (p.Glu219Ala)single nucleotide variantPathogenicrs137852603GRCh37Chr 10, 112039775: 112039775
10ARNM_000044.3(AR): c.1943G> A (p.Ser648Asn)single nucleotide variantPathogenicrs137852584GRCh37Chr X, 66931301: 66931301
11ARNM_000044.3(AR): c.2191G> A (p.Val731Met)single nucleotide variantPathogenicrs137852571GRCh37Chr X, 66937337: 66937337
12ARNM_000044.3(AR): c.2632A> G (p.Thr878Ala)single nucleotide variantPathogenicrs137852578GRCh37Chr X, 66943552: 66943552
13ARNM_000044.3(AR): c.2633C> G (p.Thr878Ser)single nucleotide variantPathogenicrs137852580GRCh37Chr X, 66943553: 66943553
14ARNM_000044.3(AR): c.2623C> T (p.His875Tyr)single nucleotide variantPathogenicrs137852581GRCh37Chr X, 66943543: 66943543
15ARNM_000044.3(AR): c.2708A> G (p.Gln903Arg)single nucleotide variantPathogenicrs137852582GRCh37Chr X, 66943628: 66943628
16ARNM_000044.3(AR): c.2164G> A (p.Ala722Thr)single nucleotide variantPathogenicrs137852583GRCh37Chr X, 66931522: 66931522

Expression for genes affiliated with Prostate Cancer

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Cancer

Search GEO for disease gene expression data for Prostate Cancer.

Pathways for genes affiliated with Prostate Cancer

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters
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Pathways related to Prostate Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8AR, CDH1, CHEK2, BRCA2, PTEN
2
Show member pathways
Signaling Pathways in Glioblastoma39
10.8PTEN, BRCA2, SRD5A2, CDH1, AR
310.8PTEN, BRCA2, CHEK2, CD82, AR
410.7AR, CDH1, BRCA2, PTEN
5
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
10.7AR, CHEK2, PTEN
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
10.7PTEN, SRD5A2, AR
7
Show member pathways
DNA damage response39
10.7CD82, CHEK2, PTEN

Compounds for genes affiliated with Prostate Cancer

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Sources:
46Novoseek, 62Tocris Bioscience, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB
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Compounds related to Prostate Cancer according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1testosterone46 62 25 1214.2PTEN, BRCA2, RNASEL, SRD5A2, CDH1, AR
2retinoic acid46 2512.2PTEN, BRCA2, EPHB2, CHEK2, CDH1, AR
3arginine4611.2PTEN, RNASEL, EPHB2, SRD5A2, CDH1, AR
4etoposide46 52 62 1214.2PTEN, BRCA2, CHEK2, CDH1, AR
5paraffin4611.2AR, CDH1, CD82, BRCA2, PTEN
6genistein46 30 62 3 25 1216.2PTEN, BRCA2, CHEK2, CDH1, AR
7progesterone46 30 62 25 1215.1AR, CDH1, SRD5A2, BRCA2, PTEN
8indole-3-carbinol4611.1AR, CDH1, BRCA2, PTEN
9adenine46 25 1213.1RNASEL, SRD5A2, CDH1, AR
10phosphatidylinositol4611.1PTEN, BRCA2, EPHB2, CHEK2, CDH1
11tamoxifen46 52 30 1214.1PTEN, BRCA2, CDH1, AR
12vitamin d4611.1AR, CDH1, SRD5A2, PTEN
13rapamycin4611.1PTEN, CHEK2, CDH1, AR
14doxorubicin46 52 1213.1AR, CDH1, CHEK2, PTEN
15estradiol46 25 1213.0AR, SRD5A2, BRCA2, PTEN
16glutamine4611.0AR, CDH1, SRD5A2, BRCA2
17adriamycin4611.0BRCA2, CHEK2, CDH1
18dutasteride46 1212.0SRD5A2, AR
19troglitazone46 30 62 1214.0AR, CDH1, PTEN
20estrogen4611.0AR, CDH1, SRD5A2, BRCA2, PTEN
21docetaxel46 52 62 1213.9BRCA2, CDH1, AR
22cisplatin46 52 62 1213.9PTEN, BRCA2, CHEK2, CDH1
23mg 13246 6211.9PTEN, CDH1, AR
24sodium bisulfite4610.9AR, CDH1
25dihydrotestosterone46 30 25 1213.9SRD5A2, CDH1, AR
26leucine4610.9PTEN, SRD5A2, MXI1, CDH1
27finasteride46 62 25 1213.9SRD5A2, AR
28serine4610.8AR, CDH1, ELAC2, CHEK2, EPHB2, PTEN
295-aza-2deoxycytidine4610.8AR, CDH1, PTEN
30danazol46 25 1212.7CDH1, AR
31calcitriol46 62 25 1213.7AR, CDH1, PTEN
32o6-methylguanine4610.5BRCA2, CDH1
33cycloheximide4610.4AR, RNASEL, BRCA2, PTEN

GO Terms for genes affiliated with Prostate Cancer

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Sources:
17Gene Ontology
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Cellular components related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Schmidt-Lanterman incisureGO:04322010.6CDH1, PTEN

Biological processes related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spine morphogenesisGO:06099710.6EPHB2, PTEN
2response to gamma radiationGO:01033210.6CHEK2, BRCA2
3negative regulation of axonogenesisGO:05077110.5EPHB2, PTEN
4positive regulation of transcription, DNA-templatedGO:04589310.4BRCA2, CHEK2, CDH1, AR

Products for genes affiliated with Prostate Cancer

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Sources for Prostate Cancer

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet