Prostate Cancer malady
Categories: Genetic diseases, Rare diseases, Cancer diseases, Reproductive diseases
50OMIM, 33LifeMap Discovery®, 11Disease Ontology, 46NIH Rare Diseases, 23GeneTests, 24Genetics Home Reference, 13DISEASES, 52Orphanet, 68UniProtKB/Swiss-Prot, 25GTR, 12diseasecard, 48Novoseek, 36MedlinePlus, 2CDC, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 43NCIt, 67UMLS via Orphanet, 29ICD10 via Orphanet, 38MESH via Orphanet, 35MedGen, 60SNOMED-CT, 62The Human Phenotype Ontology
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Aliases & Descriptions for Prostate Cancer:
Orphanet epidemiological data:52
familial prostate cancer:
Prevalence: 1-9/100000 (United States); Age of onset: Adult
Inheritance: autosomal dominant inheritance
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Reproductive diseases
Rare urogenital diseases
MedlinePlus:36 The prostate is the gland below a man's bladder that produces fluid for semen. prostate cancer is common among older men. it is rare in men younger than 40. risk factors for developing prostate cancer include being over 65 years of age, family history, and being african-american. symptoms of prostate cancer may include problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling low back pain pain with ejaculation to diagnose prostate cancer, you doctor may do a digital rectal exam to feel the prostate for lumps or anything unusual. you may also get a blood test for prostate-specific antigen (psa). these tests are also used in prostate cancer screening, which looks for cancer before you have symptoms. if your results are abnormal, you may need more tests, such as an ultrasound, mri, or biopsy. treatment often depends on the stage of the cancer. how fast the cancer grows and how different it is from surrounding tissue helps determine the stage. men with prostate cancer have many treatment options. the treatment that's best for one man may not be best for another. the options include watchful waiting, surgery, radiation therapy, hormone therapy, and chemotherapy. you may have a combination of treatments. nih: national cancer institute
MalaCards based summary: Prostate Cancer, also known as prostate carcinoma, is related to familial breast cancer and prostate cancer 1, and has symptoms including tremor, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways are Integrated Breast Cancer Pathway and Integrated Pancreatic Cancer Pathway. The drugs aminoglutethimide and chlorotrianisene have been mentioned in the context of this disorder. Affiliated tissues include the prostate, prostate and bone, and related mouse phenotypes are reproductive system and cellular.
Disease Ontology:11 A male reproductive organ cancer that is located in the prostate.
NIH Rare Diseases:46 Familial prostate cancer is a cluster of prostate cancer within a family. most cases of prostate cancer occur sporadically in people with no family history of the condition. however, approximately 5% to 10% of prostate cancer cases are believed to be primarily caused by a genetic predisposition to the condition. in many families, the underlying genetic cause is unknown; however, some of these cases are caused by changes (mutations) in the brca1, brca2, hoxb13, or several other genes. other cases are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle.high-risk cancer screening at an earlier age is typically recommended in men who have an increased risk for prostate cancer based on personal and/or family histories. last updated: 12/7/2015
UniProtKB/Swiss-Prot:68 Prostate cancer: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
CDC:2 Prostate cancer is the most common non-skin cancer among American men. Prostate cancers usually grow slowly. Most men with prostate cancer are older than 65 years and do not die from the disease. Finding and treating prostate cancer before symptoms occur may not improve your health or help you live longer.
Genetics Home Reference:24 Prostate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal and multiply without control or order to form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm.
Novus Biologicals:49 Prostate cancer is the most common non-skin cancer and second most deadly cancer for men in the United States. Prostate cancer occurs when cells within the prostate grow uncontrollably and create small tumors. If untreated, cells from these tumors can spread via metastasis. Metastasis transports prostate cancer cells through the lymphatic system and bloodstream to other parts of the body where they can grow into secondary tumors. PSA, a protein produced by the prostate, is released into the bloodstream in small amounts under normal conditions. However, PSA is released in increasing amounts when the prostate is malfunctioning, as is the case with prostate cancer.
Wikipedia:69 Prostate cancer, also known as carcinoma of the prostate, is the development of cancer in the prostate,... more...
Description from OMIM:50 176807
FDA approved drugs:(show all 18)
Drugs for Prostate Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 481)
Interventional clinical trials:(show top 50) (show all 3667)
Search NIH Clinical Center for Prostate Cancer
Inferred drug relations via UMLS66/NDF-RT44:Show with subtypes
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Prostate Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Prostate Cancer:
MalaCards organs/tissues related to Prostate Cancer:34
Prostate, Bone, Breast, Lung, Testes, Lymph node, Endothelial
FMA organs/tissues related to Prostate Cancer:17
MGI Mouse Phenotypes related to Prostate Cancer:39
Articles related to Prostate Cancer:(show top 50) (show all 12565)
UniProtKB/Swiss-Prot genetic disease variations for Prostate Cancer:68 (show all 23)
Clinvar genetic disease variations for Prostate Cancer:5 (show all 46)