MCID: PRS040
MIFTS: 98

Prostate Cancer malady

Genetic diseases, Rare diseases, Cancer diseases, Reproductive diseases categories
Download this MalaCard

Summaries for Prostate Cancer

About this section


Fully expand this MalaCard
MedlinePlus:33 The prostate is the gland below a man's bladder that produces fluid for semen. prostate cancer is common among older men. it is rare in men younger than 40. risk factors for developing prostate cancer include being over 65 years of age, family history, and being african-american. symptoms of prostate cancer may include problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling low back pain pain with ejaculation to diagnose prostate cancer, you doctor may do a digital rectal exam to feel the prostate for lumps or anything unusual. you may also get a blood test for prostate-specific antigen (psa). these tests are also used in prostate cancer screening, which looks for cancer before you have symptoms. if your results are abnormal, you may need more tests, such as an ultrasound, mri, or biopsy. treatment often depends on the stage of the cancer. how fast the cancer grows and how different it is from surrounding tissue helps determine the stage. men with prostate cancer have many treatment options. the treatment that's best for one man may not be best for another. the options include watchful waiting, surgery, radiation therapy, hormone therapy, and chemotherapy. you may have a combination of treatments. nih: national cancer institute

MalaCards based summary: Prostate Cancer, also known as prostate cancer, familial, is related to adenocarcinoma and leukemia, and has symptoms including An important gene associated with Prostate Cancer is AR (androgen receptor), and among its related pathways are Integrated Breast Cancer Pathway and Integrated Pancreatic Cancer Pathway. The drugs cisplatin and cisplatin pwdr and the compounds testosterone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include the prostate, prostate and bone, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Disease Ontology:8 A male reproductive organ cancer that is located in the prostate.

Novus Biologicals:45 Prostate cancer is the most common non-skin cancer and second most deadly cancer for men in the United States. Prostate cancer occurs when cells within the prostate grow uncontrollably and create small tumors. If untreated, cells from these tumors can spread via metastasis. Metastasis transports prostate cancer cells through the lymphatic system and bloodstream to other parts of the body where they can grow into secondary tumors. PSA, a protein produced by the prostate, is released into the bloodstream in small amounts under normal conditions. However, PSA is released in increasing amounts when the prostate is malfunctioning, as is the case with prostate cancer.

Wikipedia:65 Prostate cancer, also known as carcinoma of the prostate, is the development of cancer in the prostate,... more...

Descriptions from OMIM:46 176807, 608658, 601518, 609558, 611100 610997, 609299, 611928, 610321, 611958, 300704, 611955, 608656, 611959, 300147, 614761, 602759, 611868, 603688, 614731 more

Aliases & Classifications for Prostate Cancer

About this section
Sources:
30LifeMap Discovery®, 8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 42NIH Rare Diseases, 62UMLS, 22GTR, 20GeneTests, 48Orphanet, 57SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Prostate Cancer, Aliases & Descriptions:

Name: Prostate Cancer 30 8 9 46 10 44 33
Prostate Cancer, Familial 8 42 46 62
Malignant Tumor of the Prostate 8 22 62
Hereditary Prostate Cancer 8 42 62
Carcinoma of Prostate 8 20 62
Prostate Carcinoma 8 44 62
Ngp - New Growth of Prostate 8 62
Prostate Cancer, Hereditary 42 46
Familial Prostate Cancer 42 48
 
Tumor of the Prostate 8 62
Malignant Neoplasm of Prostate 62
Malignant Neoplasms 62
Prostatic Neoplasms 62
Prostatic Neoplasm 8
Cancer of Prostate 8
Prostate Neoplasm 8
Prostatic Cancer 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
familial prostate cancer:
Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:10283, DOID:10286
NCIt39 C3343, C4863
MESH via Orphanet35 C537243
ICD10 via Orphanet26 C61
UMLS via Orphanet63 C2931456
ICD1025 C61

Related Diseases for Prostate Cancer

About this section

Diseases in the Prostate Cancer family:

Prostate Carcinoma in Situ Prostate Cancer 1
Prostate Cancer, Hereditary, 12 Prostate Cancer, Hereditary, 5
Prostate Cancer 4 Prostate Cancer, Hereditary, 10
Prostate Cancer, Hereditary, 13 Prostate Cancer, Hereditary, 14
Prostate Cancer, Hereditary, 7 Prostate Cancer, Hereditary, 2
Prostate Cancer, Hereditary, 11 Prostate Cancer, Hereditary, 9
Prostate Cancer, Hereditary, 15 Prostate Cancer 3

Diseases related to Prostate Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 346)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma32.3PTEN, BRCA2, BRCA1, CHEK2, MSMB, HNF1B
2leukemia32.1MXI1, BRCA2, RNASEL, CHEK2, CD82, BRCA1
3breast cancer32.0BRCA2, BRCA1
4gynecomastia31.9BRCA2, BRCA1, SRD5A2, AR
5retinoblastoma31.7CHEK2, BRCA1, BRCA2, AR
6melanoma31.7CD82, CDH1, MXI1, CHEK2, PTEN, BRCA2
7colorectal cancer31.7PTEN, BRCA1, BRCA2, EPHB2, CHEK2, CD82
8androgenetic alopecia31.5SRD5A2, AR
9male breast cancer31.5BRCA2, AR, BRCA1
10lynch syndrome31.4BRCA2, BRCA1
11ovarian cancer31.4CDH1, BRCA1, BRCA2, PTEN, HNF1B
12bilateral breast cancer31.3BRCA2, CHEK2, BRCA1
13adenoma31.2CDH1, CD82, EPHB2, BRCA1
14lung cancer31.2BRCA2, CDH1, CD82, MSMB, CHEK2
15liver cancer31.1AR, CD82, HNF1B, SRD5A2, BRCA2, CDH1
16glioblastoma31.1CHEK2, MXI1, EPHB2, PTEN
17androgen insensitivity syndrome31.1AR, SRD5A2
18nijmegen breakage syndrome31.0BRCA1, CHEK2
19ataxia telangiectasia31.0CHEK2, BRCA2, BRCA1
20pancreatic cancer30.9BRCA2, BRCA1, CDH1, CD82
21prostatitis12.0
22endotheliitis11.0
23hypoxia10.9
24colonic benign neoplasm10.8EPHB2, CHEK2, BRCA2, CDH1, CD82, PTEN
25stomach cancer10.7CDH1, PTEN, CHEK2, CD82
26breast ductal carcinoma10.7AR, CDH1, BRCA1
27follicular adenoma10.7CDH1, AR, PTEN
28endometrial carcinoma10.7PTEN, BRCA2, BRCA1, CDH1
29familial colorectal cancer10.7BRCA2, BRCA1, PTEN
30cowden disease10.7PTEN, BRCA1, BRCA2
31ductal carcinoma in situ10.7BRCA1, CDH1, BRCA2
32brca1 and brca2 hereditary breast and ovarian cancer10.7BRCA2, BRCA1
33penis agenesis10.7AR, SRD5A2
34fallopian tube cancer10.7BRCA1, BRCA2
35peritoneal carcinoma10.7BRCA1, BRCA2
36breast-ovarian cancer, familial, 110.7BRCA2
37prostatic hypertrophy10.6
38pseudohermaphroditism10.6AR, SRD5A2
39obesity10.6
40prostate disease10.6
41dysgerminoma10.6BRCA2, BRCA1
42breast cancer, invasive ductal10.6BRCA1, CDH1
43somatostatin analog10.6
44papillary thyroid carcinoma10.6HNF1B, PTEN
45proctitis10.6
46peutz-jeghers syndrome10.5PTEN, BRCA2
47blindness10.5
48hypospadias10.5SRD5A2, AR
49li-fraumeni syndrome10.5BRCA2, BRCA1
50osteoporosis10.5

Graphical network of the top 20 diseases related to Prostate Cancer:



Diseases related to prostate cancer

Symptoms for Prostate Cancer

About this section

Symptoms by clinical synopsis from OMIM:

176807

Clinical features from OMIM:

176807, 608658, 601518, 609558, 611100, 610997, 609299, 611928, 610321, 611958 300704, 611955, 608656, 611959, 300147, 614761, 602759, 611868, 603688, 614731 more

HPO human phenotypes related to Prostate Cancer:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 prostate cancer HP:0012125

Drugs & Therapeutics for Prostate Cancer

About this section

Genetic Tests for Prostate Cancer

About this section

Genetic tests related to Prostate Cancer:

id Genetic test Affiliating Genes
1 Prostate Cancer20 SRD5A2
2 Malignant Tumor of Prostate22

Anatomical Context for Prostate Cancer

About this section

MalaCards organs/tissues related to Prostate Cancer:

32
Prostate, Bone, Breast, Endothelial, Lymph node, Testes, Skin, T cells, Bone marrow, Lung, Pituitary, Liver, Testis, Colon, Monocytes, Brain, Kidney, Heart, Myeloid, Nk cells, B cells, Adipocyte, Placenta, Spinal cord, Eye, Whole blood, Pancreas, Thyroid, Salivary gland, Ovary, Cervix, Tongue, Pineal

FMA organs/tissues related to Prostate Cancer:

14
The prostate

Animal Models for Prostate Cancer or affiliated genes

About this section

MGI Mouse Phenotypes related to Prostate Cancer:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537911.6MSMB, ZFHX3, AR, CDH1, MXI1, SRD5A2
2MP:000538711.6BRCA2, CDH1, BRCA1, MSR1, PTEN, CHEK2
3MP:001076811.5BRCA1, BRCA2, EPHB2, CHEK2, MSR1, MXI1
4MP:000538911.5EPHB2, MSMB, SRD5A2, MXI1, CDH1, BRCA2
5MP:000200611.5BRCA1, AR, PTEN, CDH1, MXI1, MSMB
6MP:000538411.3EPHB2, RNASEL, AR, BRCA1, MXI1, CHEK2
7MP:000536711.2AR, BRCA1, MXI1, HNF1B, PTEN, ZFHX3
8MP:000537611.2AR, CDH1, MXI1, MSR1, CHEK2, BRCA2
9MP:000539711.2AR, RNASEL, CHEK2, BRCA1, MXI1, MSR1
10MP:000538011.0AR, PTEN, BRCA2, BRCA1, HNF1B, CDH1
11MP:000538110.9BRCA2, BRCA1, PTEN, EPHB2, CDH1, AR
12MP:000537810.8CDH1, ZFHX3, BRCA2, BRCA1, EPHB2, HNF1B

Publications for Prostate Cancer

About this section

Articles related to Prostate Cancer:

(show top 50)    (show all 10971)
idTitleAuthorsYear
1
Re: Effect of Soy Protein Isolate Supplementation on Biochemical Recurrence ofA Prostate Cancer after Radical Prostatectomy: A Randomized Trial. (24331479)
2014
2
Lumican expression, localization and antitumor activity in prostate cancer. (23399832)
2013
3
Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. (23676682)
2013
4
Pre-prostatic tissue removed in robotic assisted lymph node dissection for prostate cancer contains lymph nodes. (24311906)
2013
5
Pre-chemotherapy Abiraterone Acetate. A Proposal of a Treatment Algorithm in Castration Resistant Prostate Cancer. (24342031)
2013
6
No evidence of FGFR3 mutations in prostate cancer. (20957671)
2011
7
PPARI^ disease gene network and identification of therapeutic targets for prostate cancer. (21780947)
2011
8
Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. (19820934)
2010
9
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF- kappaB activity in prostate cancer cells. (20068069)
2010
10
CYP17 polymorphisms and prostate cancer outcomes. (20503394)
2010
11
Promising tumor-associated antigens for future prostate cancer therapy. (19536865)
2010
12
Other biomarkers for detecting prostate cancer. (19930175)
2010
13
Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. (18824345)
2009
14
Biopsy tissue microarray study of Ki-67 expression in untreated, localized prostate cancer managed by active surveillance. (18762814)
2009
15
Y chromosome haplotypes and prostate cancer in Sweden. (18927315)
2008
16
A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. (18703514)
2008
17
Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk: a replication study in an ethnically homogeneous population. (18537123)
2008
18
ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel. (18628469)
2008
19
P2Y purinergic receptor activated PI-3K/Akt signaling pathway in regulation of growth and invasion of prostatic cancer]. (18194602)
2007
20
Locally advanced prostate cancer: biochemical results from a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific antigen recurrence after radiotherapy. (17559131)
2007
21
Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer. (16698360)
2006
22
Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer. (16388505)
2006
23
Characterization of frequently deleted 6q locus in prostate cancer. (17132090)
2006
24
Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. (16461912)
2006
25
Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer. (16161052)
2006
26
Targeting stathmin in prostate cancer. (16373697)
2005
27
A novel knock-in prostate cancer model demonstrates biology similar to that of human prostate cancer and suitable for preclinical studies. (15727931)
2005
28
Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. (16005185)
2005
29
An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. (15266311)
2004
30
Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer. (15280008)
2004
31
Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events. (15390081)
2004
32
Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease. (14716676)
2004
33
Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population]. (14574802)
2003
34
A comparative study of prostate specific antigen (PSA), C-terminal propeptide of blood type I procollagen (PICP) and urine type I collagen-crosslinked N telopeptide (NTx) levels using bone scintigraphy in prostate cancer patients. (12932112)
2003
35
Metastatic prostate cancer with normal level of serum prostate-specific antigen. (15072491)
2003
36
A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. (12711671)
2003
37
A phase II Hoosier Oncology Group study of vinorelbine and estramustine phosphate in hormone-refractory prostate cancer. (11996476)
2002
38
Differential activation of the IGF binding protein-3 promoter by butyrate in prostate cancer cells. (11956160)
2002
39
Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells. (12269771)
2002
40
The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. (12239635)
2002
41
Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. (11228105)
2001
42
Endothelin-1 production by prostate cancer cell lines is up-regulated by factors involved in cancer progression and down-regulated by androgens. (11746273)
2001
43
A novel human cancer culture model for the study of prostate cancer. (11753687)
2001
44
Contrasting effects of aspirin on prostate cancer cells: suppression of proliferation and induction of drug resistance . (10639187)
2000
45
BRCA1 and BRCA2 have a limited role in familial prostate cancer. (10728701)
2000
46
Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. (10475365)
1999
47
The combination of human glandular kallikrein and free prostate-specific antigen (PSA) enhances discrimination between prostate cancer and benign prostatic hyperplasia in patients with moderately increased total PSA. (10545066)
1999
48
Clinical pharmacokinetics of the antiandrogens and their efficacy in prostate cancer. (9592622)
1998
49
NGF-beta, NE-cells and prostatic cancer cell lines. A study of neuroendocrine expression in the human prostatic cancer cell lines DU-145, PC-3, LNCaP, and TSU-pr1 following stimulation of the nerve growth factor-beta. (9561567)
1998
50
Free and total serum PSA values in patients with prostatic intraepithelial neoplasia (PIN), prostate cancer and BPH. Is F/T PSA a potential probe for dormant and manifest cancer? (9179191)
1997

Variations for Prostate Cancer

About this section

UniProtKB/Swiss-Prot genetic disease variations for Prostate Cancer:

64 (show all 63)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg180CysVAR_019103rs77130927
3CHEK2p.Arg180CysVAR_019103rs77130927
4CHEK2p.Arg181CysVAR_019104rs137853010
5CHEK2p.Arg181CysVAR_019104rs137853010
6CHEK2p.Arg181CysVAR_019104rs137853010
7CHEK2p.Arg181HisVAR_019105rs121908701
8CHEK2p.Arg181HisVAR_019105rs121908701
9CHEK2p.Arg181HisVAR_019105rs121908701
10CHEK2p.Glu239LysVAR_019106
11CHEK2p.Glu239LysVAR_019106
12CHEK2p.Glu239LysVAR_019106
13CHEK2p.Glu64LysVAR_019107
14CHEK2p.Glu64LysVAR_019107
15CHEK2p.Glu64LysVAR_019107
16CHEK2p.Arg145ProVAR_019108
17CHEK2p.Arg145ProVAR_019108
18CHEK2p.Arg145ProVAR_019108
19CHEK2p.Gly167ArgVAR_019109
20CHEK2p.Gly167ArgVAR_019109
21CHEK2p.Gly167ArgVAR_019109
22CHEK2p.Arg180HisVAR_019110rs137853009
23CHEK2p.Arg180HisVAR_019110rs137853009
24CHEK2p.Arg180HisVAR_019110rs137853009
25CHEK2p.Ile251PheVAR_019111
26CHEK2p.Ile251PheVAR_019111
27CHEK2p.Ile251PheVAR_019111
28CHEK2p.Arg318HisVAR_019112rs143611747
29CHEK2p.Arg318HisVAR_019112rs143611747
30CHEK2p.Arg318HisVAR_019112rs143611747
31CHEK2p.Thr323ProVAR_019113
32CHEK2p.Thr323ProVAR_019113
33CHEK2p.Thr323ProVAR_019113
34CHEK2p.Tyr327CysVAR_019114
35CHEK2p.Tyr327CysVAR_019114
36CHEK2p.Tyr327CysVAR_019114
37CHEK2p.Thr476LysVAR_019115
38CHEK2p.Thr476LysVAR_019115
39CHEK2p.Thr476LysVAR_019115
40EPHB2p.Arg199HisVAR_032853
41EPHB2p.Arg199HisVAR_032853
42EPHB2p.Arg199HisVAR_032853
43EPHB2p.Ala279SerVAR_032854rs35882952
44EPHB2p.Ala279SerVAR_032854rs35882952
45EPHB2p.Ala279SerVAR_032854rs35882952
46EPHB2p.Val650AlaVAR_032855rs142173175
47EPHB2p.Val650AlaVAR_032855rs142173175
48EPHB2p.Val650AlaVAR_032855rs142173175
49EPHB2p.His679AsnVAR_032856
50EPHB2p.His679AsnVAR_032856
51EPHB2p.His679AsnVAR_032856
52EPHB2p.Met883ValVAR_032857
53EPHB2p.Met883ValVAR_032857
54EPHB2p.Met883ValVAR_032857
55EPHB2p.Ile909MetVAR_032858
56EPHB2p.Ile909MetVAR_032858
57EPHB2p.Ile909MetVAR_032858
58MXI1p.Glu152AlaVAR_004499
59MXI1p.Glu152AlaVAR_004499
60MXI1p.Glu152AlaVAR_004499
61PTENp.Met134LeuVAR_007469
62PTENp.Met134LeuVAR_007469
63PTENp.Met134LeuVAR_007469

Clinvar genetic disease variations for Prostate Cancer:

6 (show all 28)
id Gene Name Type Significance SNP ID Assembly Location
1RNASELNM_021133.3(RNASEL): c.793G> T (p.Glu265Ter)single nucleotide variantPathogenicrs74315364GRCh37Chr 1, 182555149: 182555149
2RNASELNM_021133.3(RNASEL): c.3G> A (p.Met1Ile)single nucleotide variantPathogenicrs74315365GRCh37Chr 1, 182555939: 182555939
3EHBP1NM_001142615.2(EHBP1): c.1185+30064G> Asingle nucleotide variantPathogenicrs721048GRCh37Chr 2, 63131731: 63131731
4MSMBNM_002443.3(MSMB): c.-89T=single nucleotide variantPathogenicrs10993994GRCh37Chr 10, 51549496: 51549496
5MSR1NM_138715.2(MSR1): c.877C> T (p.Arg293Ter)single nucleotide variantPathogenicrs41341748GRCh37Chr 8, 16012594: 16012594
6MSR1NM_138715.2(MSR1): c.520G> T (p.Asp174Tyr)single nucleotide variantPathogenicrs72552387GRCh37Chr 8, 16026077: 16026077
7ZFHX3ZFHX3, 24-BP DEL, NT10814deletionPathogenic
8ELAC2NM_018127.6(ELAC2): c.650C> T (p.Ser217Leu)single nucleotide variantPathogenicrs4792311GRCh37Chr 17, 12915009: 12915009
9ELAC2NM_018127.6(ELAC2): c.1621G> A (p.Ala541Thr)single nucleotide variantPathogenicrs5030739GRCh37Chr 17, 12899902: 12899902
10ELAC2NM_018127.6(ELAC2): c.1641dupG (p.His548Alafs)duplicationPathogenicrs387906327GRCh37Chr 17, 12899881: 12899882
11ELAC2NM_018127.6(ELAC2): c.2342G> A (p.Arg781His)single nucleotide variantPathogenicrs119484086GRCh37Chr 17, 12896274: 12896274
12ELAC2NM_018127.6(ELAC2): c.1865A> T (p.Glu622Val)single nucleotide variantPathogenicrs119484087GRCh37Chr 17, 12898323: 12898323
13EPHB2NM_004442.6(EPHB2): c.2167C> T (p.Gln723Ter)single nucleotide variantPathogenicrs121912582GRCh37Chr 1, 23234473: 23234473
14EPHB2NM_004442.6(EPHB2): c.835G> T (p.Ala279Ser)single nucleotide variantPathogenicrs35882952GRCh37Chr 1, 23189553: 23189553
15EPHB2NM_004442.6(EPHB2): c.2035G> A (p.Asp679Asn)single nucleotide variantPathogenicrs28936395GRCh37Chr 1, 23233346: 23233346
16EPHB2NM_004442.6(EPHB2): c.*187A> Tsingle nucleotide variantrisk factorrs76826147GRCh37Chr 1, 23240250: 23240250
17BRCA2BRCA2, 1-BP DEL, 6051AdeletionPathogenic
18BRCA2BRCA2, 1-BP INS, 2558AinsertionPathogenic
19MXI1MXI1, 1-BP DEL, A, CODON 140 OR 141deletionPathogenic
20MXI1NM_130439.3(MXI1): c.552+2T> Csingle nucleotide variantPathogenicrs387906417GRCh37Chr 10, 112039054: 112039054
21MXI1NM_130439.3(MXI1): c.656A> C (p.Glu219Ala)single nucleotide variantPathogenicrs137852603GRCh37Chr 10, 112039775: 112039775
22ARNM_000044.3(AR): c.1943G> A (p.Ser648Asn)single nucleotide variantPathogenicrs137852584GRCh37Chr X, 66931301: 66931301
23ARNM_000044.3(AR): c.2191G> A (p.Val731Met)single nucleotide variantPathogenicrs137852571GRCh37Chr X, 66937337: 66937337
24ARNM_000044.3(AR): c.2632A> G (p.Thr878Ala)single nucleotide variantPathogenicrs137852578GRCh37Chr X, 66943552: 66943552
25ARNM_000044.3(AR): c.2633C> G (p.Thr878Ser)single nucleotide variantPathogenicrs137852580GRCh37Chr X, 66943553: 66943553
26ARNM_000044.3(AR): c.2623C> T (p.His875Tyr)single nucleotide variantPathogenicrs137852581GRCh37Chr X, 66943543: 66943543
27ARNM_000044.3(AR): c.2708A> G (p.Gln903Arg)single nucleotide variantPathogenicrs137852582GRCh37Chr X, 66943628: 66943628
28ARNM_000044.3(AR): c.2164G> A (p.Ala722Thr)single nucleotide variantPathogenicrs137852583GRCh37Chr X, 66931522: 66931522

Expression for genes affiliated with Prostate Cancer

About this section
Expression patterns in normal tissues for genes affiliated with Prostate Cancer

Search GEO for disease gene expression data for Prostate Cancer.

Pathways for genes affiliated with Prostate Cancer

About this section

Pathways related to Prostate Cancer according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0PTEN, BRCA2, BRCA1, AR, CDH1, CHEK2
211.0AR, CHEK2, BRCA1, CD82, PTEN, BRCA2
3
Show member pathways
Signaling Pathways in Glioblastoma37
11.0PTEN, BRCA2, BRCA1, SRD5A2, CDH1, AR
410.8PTEN, BRCA2, CDH1, AR
5
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
10.8AR, PTEN, BRCA1, CHEK2
6
Show member pathways
DNA damage response37
10.8CD82, BRCA1, CHEK2, PTEN
710.7CHEK2, BRCA1, BRCA2
8
Show member pathways
10.7CHEK2, BRCA2, BRCA1
9
Show member pathways
10.7BRCA2, CHEK2, BRCA1
10
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
10.7PTEN, SRD5A2, AR
1110.7AR, BRCA1, PTEN
12
Show member pathways
10.7CHEK2, PTEN, BRCA1
1310.6BRCA1, CHEK2
14
Show member pathways
10.6BRCA1, BRCA2
15
Show member pathways
10.6BRCA1, BRCA2

Compounds for genes affiliated with Prostate Cancer

About this section

Compounds related to Prostate Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1testosterone44 61 24 1114.7RNASEL, CDH1, AR, MSMB, MSR1, BRCA1
2retinoic acid44 2412.6PTEN, AR, CDH1, HNF1B, CHEK2, EPHB2
3tyrosine4411.5MSR1, EPHB2, CDH1, CHEK2, CD82, PTEN
4arginine4411.5PTEN, SRD5A2, EPHB2, RNASEL, AR, CDH1
5phosphatidylinositol4411.5BRCA1, CDS1, CHEK2, EPHB2, BRCA2, PTEN
6etoposide44 50 61 1114.4BRCA1, BRCA2, CHEK2, CDH1, AR, PTEN
7genistein44 28 61 2 24 1116.4BRCA2, PTEN, AR, CDH1, CHEK2, BRCA1
8paraffin4411.4PTEN, BRCA2, BRCA1, CD82, CDH1, AR
9serine4411.4EPHB2, BRCA1, PTEN, CDH1, CHEK2, ELAC2
10progesterone44 28 61 24 1115.4CDH1, SRD5A2, BRCA1, BRCA2, AR, PTEN
11steroid4411.4PTEN, AR, SRD5A2, MSMB, BRCA1, BRCA2
12oligonucleotide4411.4BRCA2, HNF1B, RNASEL, PTEN, BRCA1, CHEK2
13indole-3-carbinol4411.3BRCA2, CDH1, AR, BRCA1, PTEN
14estrogen4411.3PTEN, BRCA1, SRD5A2, CDH1, AR, BRCA2
15adenine44 24 1113.3BRCA1, RNASEL, SRD5A2, AR, CDH1
16tamoxifen44 50 28 1114.3BRCA1, BRCA2, PTEN, CDH1, AR
17doxorubicin44 50 1113.3AR, PTEN, BRCA1, CHEK2, CDH1
18estradiol44 24 1113.3BRCA2, SRD5A2, BRCA1, PTEN, AR
19glutamine4411.3CDH1, AR, BRCA1, BRCA2, SRD5A2
20cisplatin44 50 61 1114.3CDH1, BRCA1, BRCA2, PTEN, CHEK2
21cycloheximide4411.3RNASEL, BRCA1, BRCA2, PTEN, AR
22adriamycin4411.2CDH1, CHEK2, BRCA1, BRCA2
23docetaxel44 50 61 1114.2BRCA1, AR, CDH1, BRCA2
24mg 13244 6112.2BRCA1, CDH1, AR, PTEN
255-aza-2deoxycytidine4411.2BRCA1, PTEN, CDH1, AR
26agar4411.2PTEN, BRCA1, CDH1, AR
27n acetylcysteine4411.2CHEK2, AR, MSR1, CDH1
28sodium bisulfite4411.2CDH1, BRCA1, AR
29vitamin d4411.1CDH1, AR, SRD5A2, PTEN
30paclitaxel44 50 1113.1CDH1, BRCA2, PTEN, BRCA1
31rapamycin4411.1CDH1, PTEN, CHEK2, AR
3217beta-hydroxysteroid4411.1AR, BRCA1, SRD5A2
33alanine4411.1CHEK2, CDH1, SRD5A2, BRCA1, PTEN
34hydroxyurea44 50 1113.0BRCA2, CHEK2, BRCA1
35gemcitabine44 50 1113.0PTEN, CHEK2, BRCA1
36nocodazole44 1112.0BRCA1, CHEK2, CDH1
37p0034411.0BRCA2, BRCA1, CDH1
38dutasteride44 1112.0SRD5A2, AR
39vincristine44 50 1113.0BRCA2, BRCA1, PTEN
40p0024411.0BRCA1, CDH1, BRCA2
41resveratrol44 61 24 1114.0AR, BRCA1, BRCA2
42troglitazone44 28 61 1114.0PTEN, CDH1, AR
43camptothecin44 61 1112.9CHEK2, BRCA1, BRCA2
44oxygen44 2411.9RNASEL, BRCA1, PTEN, CHEK2, MSR1
45dihydrotestosterone44 28 24 1113.8AR, SRD5A2, CDH1
46finasteride44 61 24 1113.8AR, SRD5A2
47bpde4410.7CHEK2, BRCA1
488-oxoguanine4410.6BRCA2, BRCA1
49daidzein4410.5BRCA1, BRCA2
505-methylcytosine44 2411.3CDH1, BRCA1

GO Terms for genes affiliated with Prostate Cancer

About this section

Cellular components related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Schmidt-Lanterman incisureGO:04322010.6CDH1, PTEN

Biological processes related to Prostate Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription, DNA-templatedGO:04589311.1AR, CDH1, HNF1B, CHEK2, BRCA1, BRCA2
2double-strand break repairGO:00630210.8BRCA2, BRCA1, CHEK2
3cellular response to indole-3-methanolGO:07168110.8CDH1, BRCA1
4response to gamma radiationGO:01033210.6CHEK2, BRCA2
5dendritic spine morphogenesisGO:06099710.6EPHB2, PTEN
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5BRCA1, BRCA2
7negative regulation of axonogenesisGO:05077110.3EPHB2, PTEN

Molecular functions related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.4PTEN, BRCA2, BRCA1, RNASEL, EPHB2, CHEK2
2transcription regulatory region DNA bindingGO:04421210.7ZFHX3, BRCA1, HNF1B, AR
3enzyme bindingGO:01989910.5PTEN, ZFHX3, BRCA1, AR

Products for genes affiliated with Prostate Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Prostate Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet