MCID: PRS040
MIFTS: 91

Prostate Cancer malady

Cancer diseases category

Summaries for Prostate Cancer

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Sources:
33MedlinePlus, 3CDC, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The prostate is the gland below a man's bladder that produces fluid for semen. prostate cancer is common among older men. it is rare in men younger than 40. risk factors for developing prostate cancer include being over 65 years of age, family history, being african-american, and some genetic changes. symptoms of prostate cancer may include problems passing urine, such as pain, difficulty starting or stopping the stream, or dribbling low back pain pain with ejaculation your doctor will diagnose prostate cancer by feeling the prostate through the wall of the rectum or doing a blood test for prostate-specific antigen (psa). other tests include ultrasound, x-rays, or a biopsy. treatment often depends on the stage of the cancer. how fast the cancer grows and how different it is from surrounding tissue helps determine the stage. men with prostate cancer have many treatment options. the treatment that's best for one man may not be best for another. the options include watchful waiting, surgery, radiation therapy, hormone therapy, and chemotherapy. you may have a combination of treatments. nih: national cancer institute

MalaCards: Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and leukemia. An important gene associated with Prostate Cancer is AR (androgen receptor), and among its related pathways are Integrated Breast Cancer Pathway and Glioma. The drugs aminoglutethimide and chlorotrianisene and the compounds testosterone and serine have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast, and related mouse phenotypes are cellular and reproductive system.

CDC:3 Prostate cancer is the most common cancer among American men. Most prostate cancers grow slowly, and don’t cause any health problems in men who have them.

Novus Biologicals:45 Prostate cancer is the most common non-skin cancer and second most deadly cancer for men in the United States. Prostate cancer occurs when cells within the prostate grow uncontrollably and create small tumors. If untreated, cells from these tumors can spread via metastasis. Metastasis transports prostate cancer cells through the lymphatic system and bloodstream to other parts of the body where they can grow into secondary tumors. PSA, a protein produced by the prostate, is released into the bloodstream in small amounts under normal conditions. However, PSA is released in increasing amounts when the prostate is malfunctioning, as is the case with prostate cancer.

Wikipedia:63 Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive... more...

Description from OMIM:46 176807

Aliases & Classifications for Prostate Cancer

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8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 22GTR, 60UMLS, 20GeneTests, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

prostate cancer 8 9 46 10 44 33 30
prostate carcinoma 8 44 60
malignant tumor of prostate 8 22
carcinoma of prostate 8 20
malignant tumor of the prostate 8
malignant neoplasm of prostate 60
ngp - new growth of prostate 8
tumor of the prostate 8
neoplasm of prostate 8
prostatic neoplasms 60
malignant neoplasms 60
prostatic neoplasm 8
cancer of prostate 8
prostate neoplasm 8
prostatic cancer 8


Related Diseases for Prostate Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Prostate Cancer family:

Prostate Carcinoma in Situ Familial Prostate Cancer
Prostate Cancer 1 Prostate Cancer 4
Prostate Cancer 3

Diseases related to Prostate Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 851)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.5KLK15, BRCA2, AR, CHEK2, CDH1, CD82
2leukemia30.9BRCA2, CHEK2, CD82, RNASEL, MXI1
3adenocarcinoma30.9BRCA2, AR, CHEK2, CDH1, CD82, MXI1
4lung cancer30.8PTEN, CDH1
5colorectal cancer30.7BRCA2, CHEK2, CDH1, CD82, EPHB2, PTEN
6gynecomastia30.7BRCA2, AR, SRD5A2
7ovarian cancer30.7BRCA2, AR, CHEK2, CDH1, EPHB2, RNASEL
8retinoblastoma30.7BRCA2, AR, CHEK2
9male breast cancer30.6BRCA2, AR
10colon cancer30.6BRCA2, CHEK2, CDH1, CD82, EPHB2, PTEN
11adenoma30.5EPHB2, CD82, CDH1
12breast-ovarian cancer, familial, 230.3BRCA2
13pancreatic cancer30.2BRCA2, CDH1, CD82
14bilateral breast cancer30.2CHEK2, BRCA2
15pancreatitis30.2BRCA2
16endometrial carcinoma30.1BRCA2, AR, CDH1, PTEN
17myeloid leukemia30.1MXI1
18bladder carcinoma30.1CD82, CDH1
19androgenic alopecia30.1AR, SRD5A2
20meningioma30.1PTEN
21stomach cancer29.9BRCA2, CHEK2, CDH1, CD82, EPHB2, ZFHX3
22hepatocellular carcinoma29.9BRCA2, AR, CDH1, CD82, SRD5A2, PTEN
23esophageal cancer29.8CDH1
24cervical cancer29.8CD82
25hepatitis c29.8RNASEL
26ductal carcinoma in situ29.8CDH1, BRCA2
27familial colorectal cancer29.8PTEN, BRCA2
28prostatitis11.9
29prostate disease11.0
30vascular cancer10.9
31cell type cancer10.9
32lymph node cancer10.8
33prostatic hypertrophy10.6
34prostate adenocarcinoma10.6
35nasopharynx carcinoma10.6
36obesity10.6
37lip cancer10.6
38pituitary cancer10.5
39proctitis10.5
40hypopharynx cancer10.5
41oropharynx cancer10.5
42osteoporosis10.5
43oral cavity cancer10.5
44familial prostate cancer10.5
45chronic fatigue syndrome10.4
46in situ carcinoma10.4
47neuronitis10.4
48hypogonadism10.4
49testicular cancer10.4
50kaposi's sarcoma10.4

Graphical network of the top 20 diseases related to Prostate Cancer:



Diseases related to prostate cancer

Clinical Features for Prostate Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

176807

Clinical synopsis from OMIM:

176807

Drugs & Therapeutics for Prostate Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Genetic Tests for Prostate Cancer

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20GeneTests, 22GTR
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Genetic tests related to Prostate Cancer:

id Genetic test Affiliating Genes
1 Prostate Cancer20 SRD5A2
2 Malignant Tumor of Prostate22

Anatomical Context for Prostate Cancer

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32MalaCards
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MalaCards organs/tissues related to Prostate Cancer:

32
Prostate, Bone, Breast, Endothelial, Lymph node, Testes, Lung, Skin, T cells, Bone marrow, Colon, Pituitary, Liver, Testis, Kidney, Monocytes, Brain, Heart, B cells, Spinal cord, Myeloid, Thyroid, Nk cells, Adipocyte, Cervix, Tongue, Placenta, Salivary gland, Pancreas, Whole blood, Ovary, Pineal

Animal Models for Prostate Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Prostate Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.7AR, SYT7, CHEK2, CDH1, EPHB2, RNASEL
2MP:000538912.4PTEN, BRCA2, SYT7, CDH1, EPHB2, ZFHX3
3MP:000200612.1BRCA2, AR, CHEK2, CDH1, ZFHX3, MXI1
4MP:000537911.2BRCA2, ZFHX3, MXI1, SRD5A2

Publications for Prostate Cancer

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Sources:
50PubMed
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Articles related to Prostate Cancer:

(show top 50)    (show all 11229)
idTitleAuthorsYear
1
The PICTURE study - Prostate Imaging (multi-parametric MRI and Prostate HistoScanninga8c) Compared to Transperineal Ultrasound guided biopsy for significant prostate cancer Risk Evaluation. (24291455)
2014
2
MHY-449, a novel dihydrobenzofuro[4,5-b][1,8] naphthyridin-6-one derivative, induces apoptotic cell death through modulation of Akt/FoxO1 and ERK signaling in PC3 human prostate cancer cells. (24424889)
2014
3
Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells. (23615977)
2013
4
A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells. (24297639)
2013
5
A Phase II study of salvage high-dose-rate brachytherapy for the treatment of locally recurrent prostate cancer after definitive external beam radiotherapy. (24373762)
2013
6
Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer. (22689130)
2012
7
Knockdown of scavenger receptor class B type I reduces prostate specific antigen secretion and viability of prostate cancer cells. (22025344)
2012
8
Delayed pituitary apoplexy in patient with advanced prostate cancer treated with gonadotrophin-releasing hormone agonists. (20605467)
2010
9
Prostate stem cell antigen enhancer and uroplakin II promoter based bladder cancer targeted tissue-specific vector. (18440837)
2010
10
Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells. (19966016)
2010
11
Chemoprevention of prostate cancer. (20152515)
2010
12
FGFR4 Gly388Arg polymorphism and prostate cancer risk in Scottish men. (19918264)
2010
13
Sequence variants at 22q13 are associated with prostate cancer risk. (19117981)
2009
14
Health-related quality of life in patients with hormone refractory prostate cancer receiving gefitinib. (19322010)
2009
15
Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men. (19528667)
2009
16
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. (18519708)
2008
17
Lack of involvement of the GNAS1 T393C polymorphism in prostate cancer risk in a Japanese population. (19189654)
2008
18
HIF-1 alpha: a key survival factor for serum-deprived prostate cancer cells. (18563715)
2008
19
Chromosomal deletion, promoter hypermethylation and downregulation of FYN in prostate cancer. (17943724)
2008
20
WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence. (18316561)
2008
21
Induction of p27(kip1) by 2,4,3',5'- tetramethoxystilbene is regulated by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells. (18816901)
2008
22
Can diet and/or sunlight modify the relationship between vitamin D receptor polymorphisms and prostate cancer risk? (17867382)
2007
23
Structural model of human PSA: a target for prostate cancer therapy. (17718721)
2007
24
Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl-2 and Bcl-xL genes. (16686729)
2006
25
Activation of the Y1 receptor by neuropeptide Y regulates the growth of prostate cancer cells. (16339211)
2006
26
Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). (16637076)
2006
27
Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial. (16679868)
2006
28
Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells. (15870880)
2005
29
Efficacy of nilutamide as secondary hormonal therapy in androgen-independent prostate cancer. (16153200)
2005
30
Genistein induces cell growth inhibition in prostate cancer through the suppression of telomerase activity. (15661057)
2005
31
Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice. (15802273)
2005
32
Cyclooxygenase-2: a therapeutic target for prostate cancer. (16425990)
2005
33
The use of trastuzumab in the treatment of hormone refractory prostate cancer; phase II trial. (15264245)
2004
34
Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer. (15663994)
2004
35
Enhanced in vitro DNA transfection efficiency by novel folate-linked nanoparticles in human prostate cancer and oral cancer. (15147814)
2004
36
Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible mechanism of action. (14751361)
2004
37
Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer. (14997205)
2004
38
The cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs celecoxib and nimesulide inhibit androgen receptor activity via induction of c-Jun in prostate cancer cells. (12917209)
2003
39
Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. (14645548)
2003
40
Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry. (12142379)
2002
41
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study. (12355549)
2002
42
Comparative analysis of complexed prostate specific antigen, free prostate specific antigen and their ratio in detecting prostate cancer. (11956430)
2002
43
PSA:alpha 1-antichymotrypsin ratio/total PSA in the diagnosis of prostatic cancer in the range of total PSA from 4 to 10 ng/ml]. (11455828)
2001
44
Establishment and characterization of a new human prostatic cancer cell line: DuCaP. (11317521)
2001
45
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray. (11384102)
2001
46
Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells. (10773882)
2000
47
Prostate specific membrane antigen (PSM) is expressed in various human tissues: implication for the use of PSM reverse transcription polymerase chain reaction to detect hematogenous prostate cancer spread. (10092150)
1999
48
Current studies of combined radiotherapy-hormone therapy in localized and locally advanced prostatic cancers]. (9922789)
1998
49
The usefulness of early whole body bone scintigraphy in the detection of bone metastasis from prostatic cancer]. (7520953)
1994
50
Genetic alterations in prostate cancer. (7587126)
1994

Genetic Variations for Prostate Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Prostate Cancer:

62 (show all 21)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg181CysVAR_019104rs137853010
3CHEK2p.Arg181HisVAR_019105rs121908701
4CHEK2p.Glu239LysVAR_019106
5CHEK2p.Glu64LysVAR_019107
6CHEK2p.Arg145ProVAR_019108
7CHEK2p.Gly167ArgVAR_019109
8CHEK2p.Arg180HisVAR_019110rs137853009
9CHEK2p.Ile251PheVAR_019111
10CHEK2p.Arg318HisVAR_019112rs143611747
11CHEK2p.Thr323ProVAR_019113
12CHEK2p.Tyr327CysVAR_019114
13CHEK2p.Thr476LysVAR_019115
14EPHB2p.Arg199HisVAR_032853
15EPHB2p.Ala279SerVAR_032854rs35882952
16EPHB2p.Val650AlaVAR_032855rs142173175
17EPHB2p.His679AsnVAR_032856
18EPHB2p.Met883ValVAR_032857
19EPHB2p.Ile909MetVAR_032858
20MXI1p.Glu152AlaVAR_004499
21PTENp.Met134LeuVAR_007469

Expression for genes affiliated with Prostate Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Cancer

Search GEO for disease gene expression data for Prostate Cancer.

Pathways for genes affiliated with Prostate Cancer

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Prostate Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.7PTEN, CDH1, CHEK2, AR, BRCA2
2
Hide members
11.7BRCA2, AR, CDH1, SRD5A2, PTEN
311.7BRCA2, AR, CHEK2, CD82, PTEN
411.5PTEN, CDH1, AR, BRCA2
5
Hide members
11.2PTEN, CHEK2, AR
6
Transcription Androgen Receptor nuclear signaling
Hide members
11.2AR, SRD5A2, PTEN
7
Hide members
11.2PTEN, CD82, CHEK2

Compounds for genes affiliated with Prostate Cancer

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Prostate Cancer according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.5KLK15, BRCA2, AR, CDH1, RNASEL, SRD5A2
2serine4412.4KLK15, AR, CHEK2, CDH1, EPHB2, PTEN
3arginine4412.2AR, CDH1, EPHB2, RNASEL, SRD5A2, PTEN
4retinoic acid44 2413.2BRCA2, AR, CHEK2, CDH1, EPHB2, PTEN
5etoposide44 49 59 1115.0BRCA2, AR, CHEK2, CDH1, PTEN
6paraffin4412.0BRCA2, AR, CDH1, CD82, PTEN
7genistein44 28 59 2 11 2417.0BRCA2, AR, CHEK2, CDH1, PTEN
8progesterone44 59 28 11 2415.9BRCA2, AR, CDH1, SRD5A2, PTEN
9indole-3-carbinol4411.8PTEN, CDH1, AR, BRCA2
10adenine44 11 2413.8SRD5A2, RNASEL, CDH1, AR
11tamoxifen44 49 28 1114.7PTEN, CDH1, AR, BRCA2
12vitamin d4411.7PTEN, SRD5A2, CDH1, AR
13rapamycin4411.7AR, CHEK2, CDH1, PTEN
14steroid4411.6KLK15, BRCA2, AR, SRD5A2
15doxorubicin44 49 1113.6PTEN, CDH1, CHEK2, AR
16dutasteride44 1112.2SRD5A2, AR
17troglitazone44 28 59 1114.2AR, CDH1, PTEN
18sodium bisulfite4411.0AR, CDH1
19finasteride44 59 11 2414.0SRD5A2, AR
20docetaxel44 49 59 1113.9AR, CDH1, BRCA2
21adriamycin4410.6CHEK2

GO Terms for genes affiliated with Prostate Cancer

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16Gene Ontology
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Cellular components related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Schmidt-Lanterman incisureGO:04322011.0PTEN, CDH1

Biological processes related to Prostate Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:05077111.0PTEN, EPHB2
2prostate gland growthGO:06073610.9PTEN, AR
3dendritic spine morphogenesisGO:06099710.7PTEN, EPHB2

Products for genes affiliated with Prostate Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostate Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet