MCID: PRS069
MIFTS: 39

Prostate Cancer, Progression and Metastasis of malady

Cancer, Genetic categories

Summaries for Prostate Cancer, Progression and Metastasis of

Sources:
47OMIM, 33MalaCards
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MalaCards: Prostate Cancer, Progression and Metastasis of, also known as familial prostate cancer, is related to bilateral breast cancer and familial prostate cancer. An important gene associated with Prostate Cancer, Progression and Metastasis of is EPHB2 (EPH receptor B2), and among its related pathways are DNA damage DNA-damage-induced responses and Recruitment of repair and signaling proteins to double-strand breaks. The compounds p005 and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotypes are embryogenesis and reproductive system.

Description from OMIM:47 602759, 603688, 608656, 608658, 609299 609558, 610321, 610997, 611100, 611868, 611928, 611955, 611958, 611959, 614731, 176807, 300147, 300704, 601518 more

Aliases & Classifications for Prostate Cancer, Progression and Metastasis of

Sources:
49Orphanet, 47OMIM, 61UMLS, 31LifeMap Discovery™, 36MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic


Characteristics (Orphanet epidemiological data):

49
familial prostate cancer:
Age of onset: Adulthood


Aliases & Descriptions:

prostate cancer, progression and metastasis of 47 31
familial prostate cancer 49 47
prostate cancer, familial 61


External Ids:

MESH via Orphanet36 C537243
ICD10 via Orphanet26 C61
UMLS via Orphanet62 C2931456

Related Diseases for Prostate Cancer, Progression and Metastasis of

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Prostate Cancer, Progression and Metastasis of via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1bilateral breast cancer30.1CHEK2, BRCA2, BRCA1
2familial prostate cancer11.0
3familial breast cancer10.2
4prostate cancer 110.2
5prostate cancer, hereditary, 210.1
6prostate cancer 310.1
7meningioma10.0RDX
8infertility10.0MSMB
9neurofibromatosis10.0RDX
10kidney cancer10.0HNF1B
11galactosemia10.0IL6
12breast-ovarian cancer, familial, 210.0BRCA2
13gout10.0HNF1B
14hepatitis b10.0KLF6, HPN
15prostate cancer10.0MXI1, ELAC2
16peritonitis10.0IL6
17pancreatitis10.0IL6, BRCA2
18cervical cancer10.0BIRC5
19endometriosis10.0HNF1B, IL6
20myeloid leukemia10.0BIRC5, MXI1
21pseudohermaphroditism10.0HSD17B3, HSD3B2, SRD5A2
22cholesteatoma10.0TNFSF11
23wilms tumor10.0BRCA2
24brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA1, BRCA2
25peritoneal carcinoma10.0BRCA2, BRCA1
26aplastic anemia10.0BRCA1, BRCA2
27fallopian tube cancer10.0BRCA2, BRCA1
28hypospadias10.0HSD3B2, SRD5A2, HSD17B3
29bloom syndrome10.0BRCA1, BRCA2
30lynch syndrome10.0BRCA2, BRCA1
31multiple myeloma10.0IL6, TNFSF11
32male breast cancer10.0BRCA1, BRCA2
33gynecomastia10.0BRCA2, SRD5A2, BRCA1
34werner syndrome10.0BRCA1, NBN
35brain cancer10.0KLF6, EPHB2, BIRC5, MXI1
36familial colorectal cancer10.0BRCA2, BRCA1
37nijmegen breakage syndrome10.0NBN, BRCA1, CHEK2
38li-fraumeni syndrome10.0BRCA1, BRCA2, CHEK2
39glioblastoma multiforme10.0BIRC5, CHEK2, KLF6, EPHB2, MXI1
40pancreatic cancer10.0BRCA1, BRCA2, BIRC5
41adenoma10.0BIRC5, EPHB2, BRCA1
42ataxia telangiectasia10.0BRCA2, BRCA1, NBN, CHEK2
43stomach cancer10.0CHEK2, BRCA2, BRCA1, EPHB2, BIRC5
44retinoblastoma10.0KLF6, CHEK2, BRCA2, BRCA1, BIRC5
45ovarian cancer10.0HPN, BRCA2, BRCA1, HNF1B, BIRC5
46colon cancer10.0BRCA1, BRCA2, KLF6, EPHB2, CHEK2, BIRC5
47breast cancer10.0CHEK2, BRCA1, BRCA2, RDX, NBN, BIRC5
48colorectal cancer10.0NBN, BRCA1, BRCA2, CHEK2, EPHB2, KLF6
49melanoma10.0BRCA2, NBN, MXI1, BIRC5, CHEK2, TNFSF11
50burkitt's lymphoma10.0BIRC5, NBN, IL6, CHEK2, BRCA2

Graphical network of the top 20 diseases related to Prostate Cancer, Progression and Metastasis of:



Diseases related to prostate cancer, progression and metastasis of

Clinical Features for Prostate Cancer, Progression and Metastasis of

Sources:
47OMIM
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Drugs & Therapeutics for Prostate Cancer, Progression and Metastasis of

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Prostate Cancer, Progression and Metastasis of

Drug clinical trials:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Prostate Cancer, Progression and Metastasis of:
PROVENGE
Embryonic/Adult Cultured Cells Related to Prostate Cancer, Progression and Metastasis of:
Activated peripheral blood derived-mononuclear cells (PROVENGE, PMIDs: 17020451, 22690467, 23582482, 22690466, 22176510, 22865266, 21788048, 22595047, 21792315, 16809734, 22036643, 20818862, 22232132, 21471425, 18094343, 22177289, 22336881, 22370520, 21943654, 22122856, 23302410, 23302902, 20592741, 23374810, 21716715, 21815700, 22111853, 21621934, 22832253, 22832254, 16736512, 21572775, 16752945, 11099318, 19536890, 23185184

Genetic Tests for Prostate Cancer, Progression and Metastasis of

Anatomical Context for Prostate Cancer, Progression and Metastasis of

Sources:
33MalaCards
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MalaCards organs/tissues related to Prostate Cancer, Progression and Metastasis of:

33
Prostate

Animal Models for Prostate Cancer, Progression and Metastasis of or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Prostate Cancer, Progression and Metastasis of

Genetic Variations for Prostate Cancer, Progression and Metastasis of

Expression for genes affiliated with Prostate Cancer, Progression and Metastasis of

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Cancer, Progression and Metastasis of

Search GEO for disease gene expression data for Prostate Cancer, Progression and Metastasis of.

Pathways for genes affiliated with Prostate Cancer, Progression and Metastasis of

Sources:
12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 4Cell Signaling Technology
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Pathways related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CHEK2, BRCA1
2
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10.0BRCA1, NBN
3
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9.9SRD5A2, HSD3B2, HSD17B3
4
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9.9SRD5A2, HSD3B2, HSD17B3
5
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9.7BRCA1, CHEK2, NBN
69.7BRCA1, CHEK2, NBN
79.7CHEK2, BRCA2, BRCA1
8
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9.7NBN, BRCA2, BRCA1
9
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9.7NBN, BRCA2, BRCA1
10
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9.7BRCA1, BRCA2, NBN
119.6BIRC5, CHEK2, BRCA2
12
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9.5HSD17B3, HSD3B2, BRCA1, CHEK2
13
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9.5NBN, CHEK2, BRCA2, BRCA1
14
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.5NBN, CHEK2, BRCA2, BRCA1
15
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9.0BRCA1, BRCA2, EPHB2, IL6, BIRC5
16
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8.8BRCA1, TNFSF11, RDX, CHEK2, EPHB2, IL6

Compounds for genes affiliated with Prostate Cancer, Progression and Metastasis of

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
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Compounds related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1p0054510.6SRD5A2
2cycloheximide4510.3BRCA2, BRCA1
3adriamycin4510.2BIRC5, CHEK2
4se-methylselenocysteine45 2411.1BIRC5, CHEK2
5androstenedione45 2411.1SRD5A2, HSD3B2, HSD17B3
6methylmethanesulfonate4510.0BRCA1, BRCA2, NBN
717beta-hydroxysteroid4510.0HSD17B3, HSD3B2, BRCA1, SRD5A2
8daidzein459.9BRCA1, BRCA2, BIRC5
9hydroxyurea45 50 1111.9BRCA1, BRCA2, CHEK2, NBN
10indole-3-carbinol459.8BIRC5, BRCA2, BRCA1
11mip 1alpha459.8TNFSF11, IL6
12gemcitabine45 50 1111.8BIRC5, CHEK2, BRCA1
13pamidronate45 50 1111.8IL6, TNFSF11
14nocodazole45 1110.7BRCA1, CHEK2, BIRC5
15bortezomib45 1110.7BRCA1, IL6, BIRC5
16adpribose459.7BRCA1, BRCA2, BIRC5
17vitamin k2459.7TNFSF11, BIRC5
18mitomycin c459.6NBN, BIRC5, BRCA2, BRCA1
19camptothecin45 60 1111.5BRCA1, BRCA2, CHEK2, BIRC5, NBN
20etoposide45 50 60 1112.4NBN, BIRC5, CHEK2, BRCA2, BRCA1
21sb 20358045 6010.4TNFSF11, EPHB2, IL6, BIRC5
22vincristine45 50 1111.4BIRC5, BRCA2, BRCA1
23rapamycin459.4NBN, BIRC5, CHEK2, TNFSF11
24progesterone45 60 29 11 2413.3HSD3B2, BRCA1, BRCA2, BIRC5, SRD5A2
25pd 98,059459.3HSD3B2, TNFSF11, EPHB2, IL6, BIRC5
26doxorubicin45 50 1111.3BRCA1, TNFSF11, CHEK2, BIRC5, NBN
27n acetylcysteine459.3TNFSF11, CHEK2, IL6, BIRC5, NBN
28p002459.2BRCA1, BRCA2, BIRC5
29methotrexate45 50 1111.2BIRC5, IL6, TNFSF11, BRCA2, BRCA1
30estradiol45 11 2411.1HSD17B3, BRCA1, BRCA2, TNFSF11, BIRC5, SRD5A2
31oligonucleotide459.1HSD3B2, HNF1B, BRCA1, BRCA2, CHEK2, RNASEL
32genistein45 29 60 2 11 2414.0BRCA1, BRCA2, TNFSF11, CHEK2, IL6, BIRC5
33steroid459.0HSD3B2, BRCA1, BRCA2, TNFSF11, BIRC5, MSMB
34retinoic acid45 249.9HNF1B, BRCA1, BRCA2, CHEK2, EPHB2, IL6
35phosphatidylinositol458.6BRCA1, BRCA2, TNFSF11, RDX, CHEK2, EPHB2
36threonine458.5TNFSF11, RDX, CHEK2, HPN, BIRC5, SRD5A2
37tyrosine458.5BRCA1, TNFSF11, RDX, CHEK2, EPHB2, IL6
38testosterone45 60 11 2411.2SRD5A2, HSD17B3, HSD3B2, BRCA1, BRCA2, TNFSF11
39serine457.7KLF6, HSD17B3, BRCA1, TNFSF11, RDX, CHEK2

GO Terms for genes affiliated with Prostate Cancer, Progression and Metastasis of

Sources:
16Gene Ontology
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Biological processes related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1androgen biosynthetic processGO:00670210.1SRD5A2, HSD3B2, HSD17B3
2steroid metabolic processGO:0082029.9SRD5A2, HSD3B2, HSD17B3
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.8BRCA1, BRCA2
4double-strand break repair via homologous recombinationGO:0007249.8BRCA1, BRCA2, NBN
5double-strand break repairGO:0063029.7BRCA1, BRCA2, CHEK2, NBN
6protein phosphorylationGO:0064689.5BIRC5, RNASEL, EPHB2, CHEK2
7monocyte chemotaxisGO:0025489.5IL6, TNFSF11
8cytokine-mediated signaling pathwayGO:0192219.3IL6, RNASEL, TNFSF11, KLF6
9positive regulation of transcription, DNA-dependentGO:0458939.0KLF6, HNF1B, BRCA1, BRCA2, CHEK2, IL6

Products for genes affiliated with Prostate Cancer, Progression and Metastasis of

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostate Cancer, Progression and Metastasis of

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet