MCID: PRS069
MIFTS: 47

Prostate Cancer, Progression and Metastasis of malady

Cancer diseases, Genetic diseases categories

Summaries for Prostate Cancer, Progression and Metastasis of

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46OMIM, 32MalaCards
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MalaCards: Prostate Cancer, Progression and Metastasis of, also known as familial prostate cancer, is related to prostate cancer and breast cancer. An important gene associated with Prostate Cancer, Progression and Metastasis of is EPHB2 (EPH receptor B2), and among its related pathways are Recruitment of repair and signaling proteins to double-strand breaks and DNA damage DNA-damage-induced responses. The compounds cycloheximide and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotypes are reproductive system and tumorigenesis.

Description from OMIM:46 602759, 603688, 608656, 608658, 609299 609558, 610321, 610997, 611100, 611868, 611928, 611955, 611958, 611959, 614731, 176807, 300147, 300704, 601518 more

Aliases & Classifications for Prostate Cancer, Progression and Metastasis of

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48Orphanet, 46OMIM, 60UMLS, 30LifeMap Discovery™, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases


Characteristics (Orphanet epidemiological data):

48
familial prostate cancer:
Age of onset: Adulthood


Aliases & Descriptions:

prostate cancer, progression and metastasis of 46 30
familial prostate cancer 48 46
prostate cancer, familial 60


External Ids:

MESH via Orphanet35 C537243
ICD10 via Orphanet26 C61
UMLS via Orphanet61 C2931456

Related Diseases for Prostate Cancer, Progression and Metastasis of

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17GeneCards, 18GeneDecks
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Diseases related to Prostate Cancer, Progression and Metastasis of via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer31.4CHEK2, EPHB2
2breast cancer30.2CHEK2, BRCA2, BRCA1, NBN, BIRC5, RDX
3lynch syndrome30.0BRCA2, BRCA1
4bilateral breast cancer30.0BRCA2, BRCA1, CHEK2
5prostatitis11.0
6familial prostate cancer10.4
7prostate disease10.2
8ependymoma10.0EZR
9peritonitis10.0IL6
10infertility10.0MSMB
11galactosemia10.0IL6
12breast-ovarian cancer, familial, 210.0BRCA2
13hepatitis b10.0HPN, KLF6
14wilms tumor10.0BRCA2
15lung cancer10.0BIRC5
16myeloid leukemia10.0BIRC5
17kidney cancer10.0HNF1B
18meningioma10.0RDX, EZR, EPB41L3
19acoustic neuroma10.0RDX, EZR
20neurofibromatosis10.0EPB41L3, RDX, EZR
21pancreatitis10.0IL6, BRCA2
22cervical cancer10.0BIRC5
23gout10.0HNF1B
24endometriosis10.0HNF1B, IL6
25brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA2, BRCA1
26peritoneal carcinoma10.0BRCA2, BRCA1
27aplastic anemia10.0BRCA2, BRCA1
28arthritis10.0TNFSF11, IL6
29multiple sclerosis10.0IL6
30fallopian tube cancer10.0BRCA1, BRCA2
31bloom syndrome10.0BRCA2, BRCA1
32male breast cancer10.0BRCA1, BRCA2
33cholesteatoma10.0TNFSF11
34werner syndrome10.0NBN, BRCA1
35sarcoma10.0CHEK2, EZR, BRCA2
36familial colorectal cancer10.0BRCA2, BRCA1
37nijmegen breakage syndrome10.0BRCA1, CHEK2, NBN
38astrocytoma10.0IL6, EZR, BRCA1, KLF6
39multiple myeloma10.0IL6, TNFSF11
40gynecomastia10.0BRCA1, BRCA2, SRD5A2
41li-fraumeni syndrome10.0BRCA1, BRCA2, CHEK2
42brain cancer10.0KLF6, EPB41L3, EPHB2, BIRC5, EZR
43glioblastoma multiforme10.0CHEK2, EPHB2, EZR, BIRC5, KLF6
44rheumatoid arthritis10.0EZR, IL6, TNFSF11, RDX
45pancreatic cancer10.0BRCA1, BRCA2, EZR, BIRC5
46adenoma10.0EPHB2, BIRC5, BRCA1
47ataxia telangiectasia10.0CHEK2, BRCA2, BRCA1, NBN
48osteosarcoma10.0BIRC5, TNFSF11, EZR, CHEK2
49ipex syndrome10.0IL6, NBN, TNFSF11, RNASEL, EZR
50retinoblastoma10.0BIRC5, KLF6, BRCA1, BRCA2, CHEK2

Graphical network of the top 20 diseases related to Prostate Cancer, Progression and Metastasis of:



Diseases related to prostate cancer, progression and metastasis of

Clinical Features for Prostate Cancer, Progression and Metastasis of

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46OMIM
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Drugs & Therapeutics for Prostate Cancer, Progression and Metastasis of

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Prostate Cancer, Progression and Metastasis of

Drug clinical trials:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Prostate Cancer, Progression and Metastasis of:
PROVENGE
Embryonic/Adult Cultured Cells Related to Prostate Cancer, Progression and Metastasis of:
Activated peripheral blood derived-mononuclear cells (PROVENGE, PMIDs: 17020451, 22690467, 23582482, 22690466, 22176510, 22865266, 21788048, 22595047, 21792315, 16809734, 22036643, 20818862, 22232132, 21471425, 18094343, 22177289, 22336881, 22370520, 21943654, 22122856, 23302410, 23302902, 20592741, 23374810, 21716715, 21815700, 22111853, 21621934, 22832253, 22832254, 16736512, 21572775, 16752945, 11099318, 19536890, 23185184

Genetic Tests for Prostate Cancer, Progression and Metastasis of

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Anatomical Context for Prostate Cancer, Progression and Metastasis of

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32MalaCards
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MalaCards organs/tissues related to Prostate Cancer, Progression and Metastasis of:

32
Prostate

Animal Models for Prostate Cancer, Progression and Metastasis of or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Prostate Cancer, Progression and Metastasis of:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.4BRCA1, BRCA2, EPHB2, HOXB13, SRD5A2, NBN
2MP:00020069.1CHEK2, EPB41L3, IL6, MSMB
3MP:00053809.0KLF6, HNF1B, EZR, HOXB13
4MP:00036318.5RDX, EPB41L3, HPN, HOXB13
5MP:00053977.8KLF6, BRCA1, BRCA2, TNFSF11, CHEK2, RNASEL
6MP:00053797.7NBN, HNF1B, BRCA1, BRCA2, EPB41L3, HPN
7MP:00053787.3HNF1B, BRCA1, BRCA2, TNFSF11, EPHB2, HPN
8MP:00053877.2CHEK2, TNFSF11, BRCA2, BRCA1, HNF1B, EZR
9MP:00053847.0KLF6, BRCA1, BRCA2, TNFSF11, CHEK2, EPB41L3
10MP:00053766.8HNF1B, BRCA1, BRCA2, TNFSF11, RDX, CHEK2
11MP:00107686.4TNFSF11, BRCA2, BRCA1, HNF1B, KLF6, CHEK2

Publications for Prostate Cancer, Progression and Metastasis of

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Genetic Variations for Prostate Cancer, Progression and Metastasis of

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Expression for genes affiliated with Prostate Cancer, Progression and Metastasis of

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Cancer, Progression and Metastasis of

Search GEO for disease gene expression data for Prostate Cancer, Progression and Metastasis of.

Pathways for genes affiliated with Prostate Cancer, Progression and Metastasis of

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53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0NBN, BRCA1
210.0CHEK2, BRCA1
3
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9.8NBN, CHEK2, BRCA1
49.8NBN, CHEK2, BRCA1
5
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9.8NBN, BRCA2, BRCA1
6
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9.8NBN, BRCA2, BRCA1
7
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9.8NBN, BRCA2, BRCA1
89.7BRCA1, BRCA2, CHEK2
99.6BRCA2, CHEK2, BIRC5
10
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9.5BRCA1, BRCA2, CHEK2, NBN
11
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.5NBN, CHEK2, BRCA2, BRCA1
12
Transcription Androgen Receptor nuclear signaling
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9.4EZR, IL6, SRD5A2
13
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9.2HNF1B, RDX, EPHB2, EZR
14
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9.0BRCA1, BRCA2, EPHB2, IL6, BIRC5
15
Hide members
8.8BRCA1, TNFSF11, RDX, CHEK2, EPHB2, IL6

Compounds for genes affiliated with Prostate Cancer, Progression and Metastasis of

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4BRCA1, BRCA2
2adriamycin4410.2BIRC5, CHEK2
3se-methylselenocysteine44 2411.1BIRC5, CHEK2
4methylmethanesulfonate4410.1NBN, BRCA2, BRCA1
5p0054410.0BRCA1, BIRC5, SRD5A2
6daidzein4410.0BIRC5, BRCA2, BRCA1
7hydroxyurea44 49 1111.9BRCA1, BRCA2, CHEK2, NBN
8indole-3-carbinol449.9BIRC5, BRCA2, BRCA1
9mip 1alpha449.8IL6, TNFSF11
10vitamin k2449.8BIRC5, TNFSF11
11adpribose449.8BIRC5, BRCA2, BRCA1
12gemcitabine44 49 1111.8BRCA1, CHEK2, BIRC5
13bortezomib44 1110.8BRCA1, IL6, BIRC5
14mitomycin c449.8NBN, BIRC5, BRCA2, BRCA1
15nocodazole44 1110.8BIRC5, CHEK2, BRCA1
16p002449.5BIRC5, BRCA2, BRCA1
17camptothecin44 59 1111.5BRCA1, BRCA2, CHEK2, BIRC5, NBN
18etoposide44 49 59 1112.5BRCA1, BRCA2, CHEK2, BIRC5, NBN
19sb 20358044 5910.5TNFSF11, EPHB2, IL6, BIRC5
20vincristine44 49 1111.4BIRC5, BRCA2, BRCA1
21rapamycin449.4TNFSF11, CHEK2, BIRC5, NBN
22doxorubicin44 49 1111.4BRCA1, TNFSF11, CHEK2, BIRC5, NBN
23estradiol44 11 2411.4BRCA1, BRCA2, TNFSF11, BIRC5, SRD5A2
24methotrexate44 49 1111.2BRCA1, BRCA2, TNFSF11, IL6, BIRC5
25pd 98,059449.2TNFSF11, EPHB2, IL6, BIRC5
26oligonucleotide449.2HNF1B, BRCA1, BRCA2, CHEK2, RNASEL, BIRC5
27steroid449.1BRCA1, BRCA2, TNFSF11, BIRC5, MSMB, SRD5A2
28n acetylcysteine449.1TNFSF11, CHEK2, IL6, BIRC5, MSR1, NBN
29superoxide44 2410.1TNFSF11, EPHB2, EZR, BIRC5, MSR1
30oxygen44 2410.1BRCA1, TNFSF11, CHEK2, RNASEL, BIRC5, MSR1
31paraffin449.0BRCA1, BRCA2, TNFSF11, EZR, BIRC5
32progesterone44 59 28 11 2413.0BRCA1, BRCA2, EPB41L3, BIRC5, SRD5A2
33nitric oxide44 11 2411.0KLF6, TNFSF11, RNASEL, IL6, BIRC5, MSR1
34thymidine44 249.9BRCA1, BRCA2, EPB41L3, IL6, BIRC5
35serine448.9KLF6, BRCA1, TNFSF11, CHEK2, HPN, NBN
36retinoic acid44 249.9HNF1B, BRCA1, BRCA2, CHEK2, EPHB2, IL6
37cholesterol44 28 11 2411.9HNF1B, EZR, IL6, BIRC5, MSR1
38alanine448.8SRD5A2, BIRC5, IL6, EZR, CHEK2, BRCA1
39atp44 289.7BRCA1, TNFSF11, CHEK2, EZR, RNASEL, BIRC5
40ly294002448.5TNFSF11, EZR, IL6, BIRC5
41genistein44 28 59 2 11 2413.5BRCA1, BRCA2, TNFSF11, CHEK2, EZR, IL6
42testosterone44 59 11 2411.4SRD5A2, BRCA1, BRCA2, TNFSF11, RNASEL, IL6
43lipid448.4BRCA1, TNFSF11, RDX, EZR, IL6, BIRC5
44phosphatidylinositol448.2BRCA1, BRCA2, TNFSF11, RDX, CHEK2, EPHB2
45threonine448.0TNFSF11, RDX, CHEK2, HPN, EZR, BIRC5
46tyrosine447.8BRCA1, TNFSF11, RDX, CHEK2, EPHB2, EZR

GO Terms for genes affiliated with Prostate Cancer, Progression and Metastasis of

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16Gene Ontology
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Cellular components related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ruffleGO:0017269.4EZR, RDX, BRCA1
2extrinsic to membraneGO:0198988.7EZR, EPB41L3, RDX

Biological processes related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1double-strand break repair via homologous recombinationGO:0007249.9BRCA1, BRCA2, NBN
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9BRCA1, BRCA2
3double-strand break repairGO:0063029.7NBN, CHEK2, BRCA2, BRCA1
4monocyte chemotaxisGO:0025489.5IL6, TNFSF11
5protein phosphorylationGO:0064689.4BIRC5, RNASEL, EPHB2, CHEK2
6cytoskeletal anchoring at plasma membraneGO:0070169.3EZR, EPB41L3
7cytokine-mediated signaling pathwayGO:0192219.3IL6, RNASEL, TNFSF11, KLF6
8positive regulation of transcription, DNA-dependentGO:0458939.0KLF6, HNF1B, BRCA1, BRCA2, CHEK2, IL6
9regulation of cell shapeGO:0083608.7IL6, EZR, HPN, EPB41L3

Molecular functions related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.3NBN, BRCA1, BRCA2, RDX, CHEK2, EPB41L3

Products for genes affiliated with Prostate Cancer, Progression and Metastasis of

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Sources for Prostate Cancer, Progression and Metastasis of

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet