Prostate Cancer, Progression and Metastasis of malady

MalaCards: Prostate Cancer, Progression and Metastasis of, also known as malignant neoplasm of prostate, is related to prostate carcinoma and prostate cancer, progression of. An important gene associated with Prostate Cancer, Progression and Metastasis of is EPHB2 (EPH receptor B2), and among its related pathways are G-protein signaling_Rac2 regulation pathway and G-protein signaling Rac2 regulation pathway. The compounds hyaluronic acid and estrogen have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotype endocrine/exocrine gland.

OMIM: 603688

prostate cancer, progression and metastasis of 33 malignant neoplasm of prostate 43

Diseases related to prostate cancer, progression and metastasis of by text searches and GeneDecks gene sharing:

(show all 45)

id	Related Disease	Score	Top Affiliating Genes
1	prostate carcinoma	28.2	HPN, EZR, IL6, KLF6
2	prostate cancer, progression of	25.6	EPHB2, EPB41L3, HPN, EZR, IL6, RDX
3	acoustic neuroma	12.7	RDX, EZR
4	neurilemmoma	12.5	RDX, EZR
5	adenoid cystic carcinoma	12.5	KLF6, EZR, EPHB2
6	adenoiditis	12.4	KLF6, EZR, EPHB2
7	pancreatic ductal carcinoma	12.3	KLF6, EZR, EPHB2
8	renal carcinoma	12.3	EPHB2, IL6, KLF6
9	basal cell carcinoma	12.3	KLF6, IL6, EPHB2
10	von hippel-lindau disease	12.2	EZR, RDX
11	neuroma	12.2	RDX, IL6, EZR
12	rhabdomyosarcoma	12.1	IL6, EZR, EPHB2
13	temporal lobe epilepsy	12.1	RDX, IL6, EZR
14	pancreatic carcinoma	12.1	IL6, EZR, EPHB2
15	ovarian carcinoma	11.9	EPHB2, HPN, EZR, IL6
16	polyposis	11.8	KLF6, IL6, EPHB2
17	renal cell carcinoma	11.8	EPHB2, HPN, EZR, IL6
18	brain cancer	11.7	EPHB2, EPB41L3, EZR, KLF6
19	glioblastoma	11.5	EPHB2, HPN, EZR, IL6, KLF6
20	breast carcinoma	11.4	RDX, IL6, EZR, EPHB2
21	neurofibromatosis	11.4	RDX, IL6, EZR, EPB41L3
22	lung carcinoma	11.3	EPB41L3, EZR, RDX, KLF6
23	meningioma	11.3	EPB41L3, EZR, IL6, RDX
24	gastric cancer	11.0	EPHB2, EPB41L3, EZR, IL6, KLF6
25	lung adenocarcinoma	10.9	EPB41L3, EZR, IL6, RDX, KLF6
26	ovarian cancer	10.7	EPHB2, EPB41L3, HPN, EZR, IL6, KLF6
27	cancer progression/metastasis	10.1	KLF6, EPHB2, EPB41L3, HPN, EZR, IL6
28	adenocarcinoma	10.1	EPHB2, EPB41L3, HPN, EZR, IL6, RDX
29	prostatitis	10.1	EPHB2, EPB41L3, HPN, EZR, IL6, RDX
30	carcinoma	10.0	EPHB2, EPB41L3, HPN, EZR, IL6, RDX
31	prostate cancer 1, 176807	6.9
32	prostate cancer, hereditary, 10	6.9
33	prostate cancer, hereditary, 14	6.9
34	prostate cancer, hereditary, 15	6.9
35	prostate cancer, hereditary, 5	6.9
36	prostate cancer, hereditary, 7	6.9
37	prostate cancer, hereditary, 9	6.9
38	prostate cancer, hereditary, x-linked 1	6.9
39	prostate cancer, hereditary, x-linked 2	6.9
40	prostate cancer	6.9
41	prostate sarcoma	6.9
42	prostatic urethral cancer	6.9
43	prostate cancer, somatic	6.9
44	prostate cancer, hereditary, 12	6.9
45	prostate cancer, hereditary, 13	6.9

Clinical features from OMIM: 603688

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to prostate cancer, progression and metastasis of:

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MGI Mouse Phenotypes related to prostate cancer, progression and metastasis of:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	7.9	KLF6, IL6, HPN, EPB41L3, EPHB2

Articles related to prostate cancer, progression and metastasis of:

id	Title	Authors	Year	Affiliating Genes
1	KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis. (18596922)	Narla G.... Martignetti J.A.	2008	KLF6
2	Protein 4.1B suppresses prostate cancer progression and metastasis. (17640904)	Wong S.Y.... Hynes R.O.	2007	RDX, EZR, EPB41L3
3	Hepsin promotes prostate cancer progression and metastasis. (15324701)	Klezovitch O.... Vasioukhin V.	2004	HPN
4	Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis. (11744478)	Shariat S.F.... Slawin K.M.	2001	IL6

Genes related to prostate cancer, progression and metastasis of according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	EPHB2	EPH receptor B2	11.0
2	HPN	hepsin	11.0	Publications
3	KLF6	Kruppel-like factor 6	11.0	Publications
4	RDX	radixin	11.0	Publications
5	EZR	ezrin	11.0	Publications
6	EPB41L3	erythrocyte membrane protein band 4.1-like 3	11.0	Publications
7	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to prostate cancer, progression and metastasis of according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	G-protein signaling_Rac2 regulation pathway41	9.3	RDX, EZR
2	G-protein signaling Rac2 regulation pathway10	9.0	RDX, EZR

Compounds related to prostate cancer, progression and metastasis of according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	hyaluronic acid32 18	9.7	EZR, IL6, RDX
2	estrogen32	8.4	EZR, IL6, RDX, KLF6
3	serine32	7.8	EPHB2, HPN, EZR, RDX, KLF6

Cellular components related to prostate cancer, progression and metastasis of according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ruffle	GO:001726	9.3	RDX, EZR
2	filopodium	GO:030175	9.2	RDX, EZR
3	apical part of cell	GO:045177	9.0	RDX, EZR
4	extrinsic to membrane	GO:019898	8.5	RDX, EZR, EPB41L3