MCID: PRS069
MIFTS: 44

Prostate Cancer, Progression and Metastasis of malady

Genetic diseases, Cancer diseases, Rare diseases categories
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Summaries for Prostate Cancer, Progression and Metastasis of

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Sources:
47OMIM, 33MalaCards
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MalaCards: Prostate Cancer, Progression and Metastasis of, also known as familial prostate cancer, is related to prostate cancer and breast cancer. An important gene associated with Prostate Cancer, Progression and Metastasis of is EPHB2 (EPH receptor B2), and among its related pathways are DNA damage DNA damage induced responses and ATM Pathway. The compounds bpde and aphidicolin have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotypes are tumorigenesis and embryogenesis.

Description from OMIM:47 602759, 603688, 608656, 608658, 609299 609558, 610321, 610997, 611100, 611868, 611928, 611955, 611958, 611959, 614731, 176807, 300147, 300704, 601518 more

Aliases & Classifications for Prostate Cancer, Progression and Metastasis of

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49Orphanet, 47OMIM, 62UMLS, 31LifeMap Discovery™, 36MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

49
familial prostate cancer:
Age of onset: Adulthood


Aliases & Descriptions:

prostate cancer, progression and metastasis of 47 31
familial prostate cancer 49 47
prostate cancer, familial 62


External Ids:

MESH via Orphanet36 C537243
ICD10 via Orphanet26 C61
UMLS via Orphanet63 C2931456

Related Diseases for Prostate Cancer, Progression and Metastasis of

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Prostate Cancer, Progression and Metastasis of:



Diseases related to prostate cancer, progression and metastasis of

Symptoms for Prostate Cancer, Progression and Metastasis of

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47OMIM
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Drugs & Therapeutics for Prostate Cancer, Progression and Metastasis of

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Drug clinical trials:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Prostate Cancer, Progression and Metastasis of:
PROVENGE
Embryonic/Adult Cultured Cells Related to Prostate Cancer, Progression and Metastasis of:
Activated peripheral blood derived-mononuclear cells (PROVENGE, PMIDs: 17020451, 22690467, 23582482, 22690466, 22176510, 22865266, 21788048, 22595047, 21792315, 16809734, 22036643, 20818862, 22232132, 21471425, 18094343, 22177289, 22336881, 22370520, 21943654, 22122856, 23302410, 23302902, 20592741, 23374810, 21716715, 21815700, 22111853, 21621934, 22832253, 22832254, 16736512, 21572775, 16752945, 11099318, 19536890, 23185184

Genetic Tests for Prostate Cancer, Progression and Metastasis of

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Anatomical Context for Prostate Cancer, Progression and Metastasis of

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33MalaCards
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MalaCards organs/tissues related to Prostate Cancer, Progression and Metastasis of:

33
Prostate

Animal Models for Prostate Cancer, Progression and Metastasis of or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Prostate Cancer, Progression and Metastasis of:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9NBN, BRCA2, BRCA1, CHEK2, MSMB
2MP:00053807.4HOXB13, NBN, BRCA2, BRCA1, HNF1B
3MP:00036317.4MSR1, EPHB2, BRCA1, BRCA2, NBN, HOXB13
4MP:00053977.3NBN, BRCA2, BRCA1, RNASEL, CHEK2, MSR1
5MP:00053897.2HOXB13, NBN, BRCA2, BRCA1, EPHB2, MSMB
6MP:00107687.1NBN, BRCA2, BRCA1, EPHB2, CHEK2, MSR1
7MP:00053797.0HNF1B, HOXB13, NBN, BRCA2, BRCA1, EPHB2
8MP:00053846.9HOXB13, NBN, BRCA2, BRCA1, RNASEL, EPHB2
9MP:00053876.9NBN, BRCA2, BRCA1, RNASEL, CHEK2, MSR1

Publications for Prostate Cancer, Progression and Metastasis of

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Variations for Prostate Cancer, Progression and Metastasis of

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Prostate Cancer, Progression and Metastasis of:

1
id Gene Name Type Significance SNP ID Assembly Location
1EPHB2NM_004442.6(EPHB2): c.2167C> T (p.Gln723Ter)single nucleotide variantPathogenicrs121912582GRCh37Chr 1, 23234473: 23234473
2EPHB2NM_004442.6(EPHB2): c.835G> T (p.Ala279Ser)single nucleotide variantPathogenicrs35882952GRCh37Chr 1, 23189553: 23189553
3EPHB2NM_004442.6(EPHB2): c.2035G> A (p.Asp679Asn)single nucleotide variantPathogenicrs28936395GRCh37Chr 1, 23233346: 23233346

Expression for genes affiliated with Prostate Cancer, Progression and Metastasis of

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Cancer, Progression and Metastasis of

Search GEO for disease gene expression data for Prostate Cancer, Progression and Metastasis of.

Pathways for genes affiliated with Prostate Cancer, Progression and Metastasis of

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50PathCards, 60Thomson Reuters, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 12EMD Millipore, 5Cell Signaling Technology
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Pathways related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CHEK2, BRCA1
2
Show member pathways
ATM Signaling Pathway38
9.5CHEK2, BRCA1
39.4CHEK2, BRCA2
49.3BRCA1, BRCA2
5
Show member pathways
9.3BRCA2, BRCA1
6
Show member pathways
Non-homologous end joining38
DNA damage NHEJ mechanisms of DSBs repair60
9.1BRCA1, NBN
79.1BRCA1, NBN
8
Show member pathways
Homologous recombination38
9.0NBN, BRCA2
9
Show member pathways
Signaling Pathways in Glioblastoma38
9.0BRCA2, BRCA1, SRD5A2
108.9CHEK2, BRCA1, BRCA2
118.9CHEK2, BRCA1, BRCA2
12
Show member pathways
8.9CHEK2, BRCA1, BRCA2
13
Show member pathways
8.9CHEK2, BRCA1, BRCA2
148.7CHEK2, BRCA1, NBN
15
Show member pathways
DNA damage response38
8.7NBN, BRCA1, CHEK2
16
Show member pathways
8.5BRCA1, BRCA2, NBN
17
Show member pathways
8.5NBN, BRCA2, BRCA1
18
Show member pathways
8.5NBN, BRCA2, BRCA1
19
Show member pathways
8.1NBN, BRCA2, BRCA1, CHEK2
208.1CHEK2, BRCA1, BRCA2, NBN

Compounds for genes affiliated with Prostate Cancer, Progression and Metastasis of

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 3BitterDB, 51PharmGKB
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Compounds related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1bpde459.9CHEK2, BRCA1
2aphidicolin459.8BRCA1, CHEK2
3p005459.8BRCA1, SRD5A2
417beta-hydroxysteroid459.7SRD5A2, BRCA1
58-oxoguanine459.6BRCA2, BRCA1
6daidzein459.6BRCA2, BRCA1
7lycopene45 2410.6BRCA2, BRCA1
8adenine45 24 1111.5BRCA1, RNASEL, SRD5A2
9indole-3-carbinol459.5BRCA1, BRCA2
10arginine459.4HNF1B, SRD5A2, EPHB2, RNASEL
11adriamycin459.3CHEK2, BRCA1, BRCA2
12n acetylcysteine459.1MSR1, CHEK2, NBN
13steroid459.0SRD5A2, MSMB, BRCA1, BRCA2
14genistein45 29 61 3 24 1113.9CHEK2, BRCA1, BRCA2
15methylmethanesulfonate458.9BRCA1, BRCA2, NBN
16mitomycin c458.9BRCA1, BRCA2, NBN
17threonine458.8NBN, CHEK2, ELAC2, SRD5A2
18tyrosine458.8BRCA1, EPHB2, CHEK2, MSR1, MSMB
19oxygen45 249.7BRCA1, RNASEL, CHEK2, MSR1
20estradiol45 24 1110.7BRCA2, BRCA1, SRD5A2
21retinoic acid45 249.7BRCA2, BRCA1, EPHB2, CHEK2, HNF1B
22doxorubicin45 51 1110.6CHEK2, BRCA1, NBN
23oligonucleotide458.5BRCA2, BRCA1, RNASEL, CHEK2, HNF1B
24hydroxyurea45 51 1110.5NBN, BRCA2, BRCA1, CHEK2
25camptothecin45 61 1110.5NBN, BRCA2, BRCA1, CHEK2
26etoposide45 51 61 1111.5NBN, BRCA2, BRCA1, CHEK2
27serine458.3NBN, BRCA1, EPHB2, CHEK2, ELAC2
28testosterone45 61 24 1111.3SRD5A2, MSMB, MSR1, RNASEL, BRCA1, BRCA2
29phosphatidylinositol458.2NBN, BRCA2, BRCA1, EPHB2, CHEK2

GO Terms for genes affiliated with Prostate Cancer, Progression and Metastasis of

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16Gene Ontology
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Cellular components related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.1CHEK2, BRCA1, BRCA2, NBN
2nucleusGO:0056346.7HNF1B, HOXB13, NBN, BRCA2, BRCA1, ELAC2

Biological processes related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.5CHEK2, BRCA1
2response to gamma radiationGO:0103329.4BRCA2, CHEK2
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4BRCA1, BRCA2
4DNA damage checkpointGO:0000779.1NBN, CHEK2
5positive regulation of transcription, DNA-templatedGO:0458938.7BRCA2, BRCA1, CHEK2, HNF1B
6double-strand break repair via homologous recombinationGO:0007248.7NBN, BRCA2, BRCA1
7double-strand break repairGO:0063028.3CHEK2, BRCA1, BRCA2, NBN
8DNA repairGO:0062818.2BRCA1, BRCA2, NBN

Molecular functions related to Prostate Cancer, Progression and Metastasis of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.7HNF1B, MSR1, CHEK2, EPHB2, RNASEL, BRCA1

Products for genes affiliated with Prostate Cancer, Progression and Metastasis of

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Sources for Prostate Cancer, Progression and Metastasis of

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet