MCID: PRS085
MIFTS: 29

Prostate Cancer, Progression of malady

Genetic diseases (common), Cancer diseases categories
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Summaries for Prostate Cancer, Progression of

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47OMIM, 33MalaCards
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MalaCards: Prostate Cancer, Progression of is related to prostate cancer and li-fraumeni syndrome. An important gene associated with Prostate Cancer, Progression of is CHEK2 (checkpoint kinase 2), and among its related pathways are Integrated Pancreatic Cancer Pathway and Integrated Breast Cancer Pathway. The compounds gemcitabine and etoposide have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotypes are vision/eye and renal/urinary system.

Description from OMIM:47 176807

Aliases & Classifications for Prostate Cancer, Progression of

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Aliases & Descriptions:

prostate cancer, progression of 47


Related Diseases for Prostate Cancer, Progression of

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Prostate Cancer, Progression of via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer30.1MXI1, CHEK2, PTEN
2li-fraumeni syndrome10.0CHEK2, PTEN
3stomach cancer10.0CHEK2, PTEN
4ovarian cancer9.9PTEN, EPHB2, CHEK2
5brain cancer9.9PTEN, MXI1, EPHB2
6colon cancer9.9CHEK2, EPHB2, PTEN
7colorectal cancer9.9CHEK2, EPHB2, PTEN
8malignant glioma9.9MXI1, PTEN, EPHB2
9adenocarcinoma9.9PTEN, MXI1, CHEK2
10glioblastoma multiforme9.9EPHB2, MXI1, PTEN, CHEK2
11melanoma9.9PTEN, CHEK2, MXI1

Graphical network of diseases related to Prostate Cancer, Progression of:



Diseases related to prostate cancer, progression of

Symptoms for Prostate Cancer, Progression of

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47OMIM
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Clinical features from OMIM:

176807

Drugs & Therapeutics for Prostate Cancer, Progression of

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Prostate Cancer, Progression of

Search NIH Clinical Center for Prostate Cancer, Progression of

Genetic Tests for Prostate Cancer, Progression of

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Anatomical Context for Prostate Cancer, Progression of

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33MalaCards
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MalaCards organs/tissues related to Prostate Cancer, Progression of:

33
Prostate

Animal Models for Prostate Cancer, Progression of or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Prostate Cancer, Progression of:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6HIP1, PTEN, EPHB2
2MP:00053678.4MXI1, EPHB2, PTEN
3MP:00020068.3HIP1, PTEN, CHEK2, MXI1
4MP:00053798.2PTEN, MXI1, EPHB2, HIP1
5MP:00053978.1MXI1, CHEK2, PTEN, HIP1
6MP:00053898.1HIP1, MXI1, PTEN, EPHB2
7MP:00053878.1MXI1, PTEN, HIP1, CHEK2
8MP:00053767.8HIP1, PTEN, CHEK2, MXI1
9MP:00053847.7HIP1, PTEN, EPHB2, CHEK2, MXI1
10MP:00107687.7EPHB2, PTEN, HIP1, CHEK2, MXI1

Publications for Prostate Cancer, Progression of

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Variations for Prostate Cancer, Progression of

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Prostate Cancer, Progression of:

64 (show all 21)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg181CysVAR_019104rs137853010
3CHEK2p.Arg181HisVAR_019105rs121908701
4CHEK2p.Glu239LysVAR_019106
5CHEK2p.Glu64LysVAR_019107
6CHEK2p.Arg145ProVAR_019108
7CHEK2p.Gly167ArgVAR_019109
8CHEK2p.Arg180HisVAR_019110rs137853009
9CHEK2p.Ile251PheVAR_019111
10CHEK2p.Arg318HisVAR_019112rs143611747
11CHEK2p.Thr323ProVAR_019113
12CHEK2p.Tyr327CysVAR_019114
13CHEK2p.Thr476LysVAR_019115
14EPHB2p.Arg199HisVAR_032853
15EPHB2p.Ala279SerVAR_032854rs35882952
16EPHB2p.Val650AlaVAR_032855rs142173175
17EPHB2p.His679AsnVAR_032856
18EPHB2p.Met883ValVAR_032857
19EPHB2p.Ile909MetVAR_032858
20MXI1p.Glu152AlaVAR_004499
21PTENp.Met134LeuVAR_007469

Clinvar genetic disease variations for Prostate Cancer, Progression of:

1 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1MSR1NM_138715.2(MSR1): c.877C> T (p.Arg293Ter)single nucleotide variantPathogenicrs41341748GRCh37Chr 8, 16012594: 16012594
2MSR1NM_138715.2(MSR1): c.520G> T (p.Asp174Tyr)single nucleotide variantPathogenicrs72552387GRCh37Chr 8, 16026077: 16026077
3ZFHX3ZFHX3, 24-BP DEL, NT10814deletionPathogenic
4BRCA2BRCA2, 1-BP DEL, 6051AdeletionPathogenic
5BRCA2BRCA2, 1-BP INS, 2558AinsertionPathogenic
6MXI1MXI1, 1-BP DEL, A, CODON 140 OR 141deletionPathogenic
7MXI1NM_130439.3(MXI1): c.552+2T> Csingle nucleotide variantPathogenicrs387906417GRCh37Chr 10, 112039054: 112039054
8MXI1NM_130439.3(MXI1): c.656A> C (p.Glu219Ala)single nucleotide variantPathogenicrs137852603GRCh37Chr 10, 112039775: 112039775
9ARNM_000044.3(AR): c.1943G> A (p.Ser648Asn)single nucleotide variantPathogenicrs137852584GRCh37Chr X, 66931301: 66931301
10ARNM_000044.3(AR): c.2191G> A (p.Val731Met)single nucleotide variantPathogenicrs137852571GRCh37Chr X, 66937337: 66937337
11ARNM_000044.3(AR): c.2632A> G (p.Thr878Ala)single nucleotide variantPathogenicrs137852578GRCh37Chr X, 66943552: 66943552
12ARNM_000044.3(AR): c.2633C> G (p.Thr878Ser)single nucleotide variantPathogenicrs137852580GRCh37Chr X, 66943553: 66943553
13ARNM_000044.3(AR): c.2623C> T (p.His875Tyr)single nucleotide variantPathogenicrs137852581GRCh37Chr X, 66943543: 66943543
14ARNM_000044.3(AR): c.2708A> G (p.Gln903Arg)single nucleotide variantPathogenicrs137852582GRCh37Chr X, 66943628: 66943628
15ARNM_000044.3(AR): c.2164G> A (p.Ala722Thr)single nucleotide variantPathogenicrs137852583GRCh37Chr X, 66931522: 66931522

Expression for genes affiliated with Prostate Cancer, Progression of

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostate Cancer, Progression of

Search GEO for disease gene expression data for Prostate Cancer, Progression of.

Pathways for genes affiliated with Prostate Cancer, Progression of

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 57SinoBiological, 30KEGG
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Pathways related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CHEK2, PTEN
29.2CHEK2, PTEN
3
Show member pathways
9.2PTEN, CHEK2
4
Show member pathways
DNA damage response38
9.2CHEK2, PTEN
5
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.2CHEK2, PTEN
69.1EPHB2, PTEN
7
Show member pathways
8.7CHEK2, EPHB2, PTEN

Compounds for genes affiliated with Prostate Cancer, Progression of

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gemcitabine45 51 1111.3CHEK2, PTEN
2etoposide45 51 61 1112.2CHEK2, PTEN
3inositol459.0HIP1, PTEN
4okadaic acid45 619.9CHEK2, PTEN
5phosphatidylinositol458.8PTEN, EPHB2, CHEK2
6adp45 29 2410.7PTEN, EPHB2, CHEK2
7retinoic acid45 249.7CHEK2, EPHB2, PTEN
8tyrosine458.3CHEK2, EPHB2, PTEN, HIP1

GO Terms for genes affiliated with Prostate Cancer, Progression of

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16Gene Ontology
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Cellular components related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.2CHEK2, PTEN

Biological processes related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spine morphogenesisGO:0609979.1EPHB2, PTEN
2angiogenesisGO:0015259.1EPHB2, PTEN
3negative regulation of axonogenesisGO:0507719.0EPHB2, PTEN
4protein stabilizationGO:0508218.9CHEK2, PTEN

Products for genes affiliated with Prostate Cancer, Progression of

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostate Cancer, Progression of

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet