MCID: PRS085
MIFTS: 29

Prostate Cancer, Progression of malady

Genetic diseases (common), Cancer diseases categories

Summaries for Prostate Cancer, Progression of

About this section
Sources:
48OMIM, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Prostate Cancer, Progression of is related to prostate cancer and li-fraumeni syndrome. An important gene associated with Prostate Cancer, Progression of is CHEK2 (checkpoint kinase 2), and among its related pathways are Integrated Pancreatic Cancer Pathway and Integrated Breast Cancer Pathway. The compounds gemcitabine and etoposide have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotypes are vision/eye and renal/urinary system.

Description from OMIM:48 176807

Aliases & Classifications for Prostate Cancer, Progression of

About this section
Sources:
48OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Aliases & Descriptions:

prostate cancer, progression of 48


Related Diseases for Prostate Cancer, Progression of

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Prostate Cancer, Progression of via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer30.1MXI1, CHEK2, PTEN
2li-fraumeni syndrome10.0CHEK2, PTEN
3stomach cancer10.0CHEK2, PTEN
4ovarian cancer9.9PTEN, EPHB2, CHEK2
5brain cancer9.9PTEN, MXI1, EPHB2
6colon cancer9.9CHEK2, EPHB2, PTEN
7colorectal cancer9.9CHEK2, EPHB2, PTEN
8malignant glioma9.9MXI1, PTEN, EPHB2
9adenocarcinoma9.9PTEN, MXI1, CHEK2
10glioblastoma multiforme9.9EPHB2, MXI1, PTEN, CHEK2
11melanoma9.9PTEN, CHEK2, MXI1

Graphical network of diseases related to Prostate Cancer, Progression of:



Diseases related to prostate cancer, progression of

Symptoms for Prostate Cancer, Progression of

About this section
Sources:
48OMIM
See all sources


Clinical features from OMIM:

176807

Drugs & Therapeutics for Prostate Cancer, Progression of

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Prostate Cancer, Progression of

Drug clinical trials:

Search ClinicalTrials for Prostate Cancer, Progression of

Search NIH Clinical Center for Prostate Cancer, Progression of

Search CenterWatch for Prostate Cancer, Progression of

Genetic Tests for Prostate Cancer, Progression of

About this section

Anatomical Context for Prostate Cancer, Progression of

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Prostate Cancer, Progression of:

34
Prostate

Animal Models for Prostate Cancer, Progression of or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Prostate Cancer, Progression of:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6HIP1, PTEN, EPHB2
2MP:00053678.4MXI1, EPHB2, PTEN
3MP:00020068.3HIP1, PTEN, CHEK2, MXI1
4MP:00053798.2PTEN, MXI1, EPHB2, HIP1
5MP:00053978.1MXI1, CHEK2, PTEN, HIP1
6MP:00053898.1HIP1, MXI1, PTEN, EPHB2
7MP:00053878.1MXI1, PTEN, HIP1, CHEK2
8MP:00053767.8HIP1, PTEN, CHEK2, MXI1
9MP:00053847.7HIP1, PTEN, EPHB2, CHEK2, MXI1
10MP:00107687.7EPHB2, PTEN, HIP1, CHEK2, MXI1

Publications for Prostate Cancer, Progression of

About this section

Variations for Prostate Cancer, Progression of

About this section
Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
See all sources

UniProtKB/Swiss-Prot genetic disease variations for Prostate Cancer, Progression of:

65 (show all 21)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg181CysVAR_019104rs137853010
3CHEK2p.Arg181HisVAR_019105rs121908701
4CHEK2p.Glu239LysVAR_019106
5CHEK2p.Glu64LysVAR_019107
6CHEK2p.Arg145ProVAR_019108
7CHEK2p.Gly167ArgVAR_019109
8CHEK2p.Arg180HisVAR_019110rs137853009
9CHEK2p.Ile251PheVAR_019111
10CHEK2p.Arg318HisVAR_019112rs143611747
11CHEK2p.Thr323ProVAR_019113
12CHEK2p.Tyr327CysVAR_019114
13CHEK2p.Thr476LysVAR_019115
14EPHB2p.Arg199HisVAR_032853
15EPHB2p.Ala279SerVAR_032854rs35882952
16EPHB2p.Val650AlaVAR_032855rs142173175
17EPHB2p.His679AsnVAR_032856
18EPHB2p.Met883ValVAR_032857
19EPHB2p.Ile909MetVAR_032858
20MXI1p.Glu152AlaVAR_004499
21PTENp.Met134LeuVAR_007469

Clinvar genetic disease variations for Prostate Cancer, Progression of:

1 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1MSR1NM_138715.2(MSR1): c.877C> T (p.Arg293Ter)single nucleotide variantPathogenicrs41341748GRCh37Chr 8, 16012594: 16012594
2MSR1NM_138715.2(MSR1): c.520G> T (p.Asp174Tyr)single nucleotide variantPathogenicrs72552387GRCh37Chr 8, 16026077: 16026077
3ZFHX3ZFHX3, 24-BP DEL, NT10814deletionPathogenic
4BRCA2BRCA2, 1-BP DEL, 6051AdeletionPathogenic
5BRCA2BRCA2, 1-BP INS, 2558AinsertionPathogenic
6MXI1MXI1, 1-BP DEL, A, CODON 140 OR 141deletionPathogenic
7MXI1NM_130439.3(MXI1): c.552+2T> Csingle nucleotide variantPathogenicrs387906417GRCh37Chr 10, 112039054: 112039054
8MXI1NM_130439.3(MXI1): c.656A> C (p.Glu219Ala)single nucleotide variantPathogenicrs137852603GRCh37Chr 10, 112039775: 112039775
9ARNM_000044.3(AR): c.1943G> A (p.Ser648Asn)single nucleotide variantPathogenicrs137852584GRCh37Chr X, 66931301: 66931301
10ARNM_000044.3(AR): c.2191G> A (p.Val731Met)single nucleotide variantPathogenicrs137852571GRCh37Chr X, 66937337: 66937337
11ARNM_000044.3(AR): c.2632A> G (p.Thr878Ala)single nucleotide variantPathogenicrs137852578GRCh37Chr X, 66943552: 66943552
12ARNM_000044.3(AR): c.2633C> G (p.Thr878Ser)single nucleotide variantPathogenicrs137852580GRCh37Chr X, 66943553: 66943553
13ARNM_000044.3(AR): c.2623C> T (p.His875Tyr)single nucleotide variantPathogenicrs137852581GRCh37Chr X, 66943543: 66943543
14ARNM_000044.3(AR): c.2708A> G (p.Gln903Arg)single nucleotide variantPathogenicrs137852582GRCh37Chr X, 66943628: 66943628
15ARNM_000044.3(AR): c.2164G> A (p.Ala722Thr)single nucleotide variantPathogenicrs137852583GRCh37Chr X, 66931522: 66931522

Expression for genes affiliated with Prostate Cancer, Progression of

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Prostate Cancer, Progression of

Search GEO for disease gene expression data for Prostate Cancer, Progression of.

Pathways for genes affiliated with Prostate Cancer, Progression of

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 58SinoBiological, 31KEGG
See all sources

Pathways related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CHEK2, PTEN
29.2CHEK2, PTEN
3
Show member pathways
9.2PTEN, CHEK2
4
Show member pathways
DNA damage response39
9.2CHEK2, PTEN
5
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.2CHEK2, PTEN
69.1EPHB2, PTEN
7
Show member pathways
8.7CHEK2, EPHB2, PTEN

Compounds for genes affiliated with Prostate Cancer, Progression of

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
See all sources

Compounds related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gemcitabine46 52 1211.3CHEK2, PTEN
2etoposide46 52 62 1212.2CHEK2, PTEN
3inositol469.0HIP1, PTEN
4okadaic acid46 629.9CHEK2, PTEN
5phosphatidylinositol468.8PTEN, EPHB2, CHEK2
6adp46 30 2510.7PTEN, EPHB2, CHEK2
7retinoic acid46 259.7CHEK2, EPHB2, PTEN
8tyrosine468.3CHEK2, EPHB2, PTEN, HIP1

GO Terms for genes affiliated with Prostate Cancer, Progression of

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166059.2CHEK2, PTEN

Biological processes related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spine morphogenesisGO:0609979.1EPHB2, PTEN
2angiogenesisGO:0015259.1EPHB2, PTEN
3negative regulation of axonogenesisGO:0507719.0EPHB2, PTEN
4protein stabilizationGO:0508218.9CHEK2, PTEN

Products for genes affiliated with Prostate Cancer, Progression of

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostate Cancer, Progression of

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet