MCID: PRS085
MIFTS: 35

Prostate Cancer, Progression of malady

Genetic diseases (common), Cancer diseases categories
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Summaries for Prostate Cancer, Progression of

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MalaCards based summary: Prostate Cancer, Progression of is related to prostate cancer and male breast cancer. An important gene associated with Prostate Cancer, Progression of is AR (androgen receptor), and among its related pathways are Coregulation of Androgen receptor activity and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds bicalutamide and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotypes are skeleton and renal/urinary system.

Description from OMIM:46 176807

Aliases & Classifications for Prostate Cancer, Progression of

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Prostate Cancer, Progression of, Aliases & Descriptions:

Name: Prostate Cancer, Progression of 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Related Diseases for Prostate Cancer, Progression of

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Graphical network of the top 20 diseases related to Prostate Cancer, Progression of:



Diseases related to prostate cancer, progression of

Symptoms for Prostate Cancer, Progression of

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Clinical features from OMIM:

176807

Drugs & Therapeutics for Prostate Cancer, Progression of

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Drug clinical trials:

Search ClinicalTrials for Prostate Cancer, Progression of

Search NIH Clinical Center for Prostate Cancer, Progression of

Genetic Tests for Prostate Cancer, Progression of

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Anatomical Context for Prostate Cancer, Progression of

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MalaCards organs/tissues related to Prostate Cancer, Progression of:

32
Prostate

Animal Models for Prostate Cancer, Progression of or affiliated genes

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Publications for Prostate Cancer, Progression of

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Variations for Prostate Cancer, Progression of

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UniProtKB/Swiss-Prot genetic disease variations for Prostate Cancer, Progression of:

64 (show all 21)
id Symbol AA change Variation ID SNP ID
1CHEK2p.Arg180CysVAR_019103rs77130927
2CHEK2p.Arg181CysVAR_019104rs137853010
3CHEK2p.Arg181HisVAR_019105rs121908701
4CHEK2p.Glu239LysVAR_019106
5CHEK2p.Glu64LysVAR_019107
6CHEK2p.Arg145ProVAR_019108
7CHEK2p.Gly167ArgVAR_019109
8CHEK2p.Arg180HisVAR_019110rs137853009
9CHEK2p.Ile251PheVAR_019111
10CHEK2p.Arg318HisVAR_019112rs143611747
11CHEK2p.Thr323ProVAR_019113
12CHEK2p.Tyr327CysVAR_019114
13CHEK2p.Thr476LysVAR_019115
14EPHB2p.Arg199HisVAR_032853
15EPHB2p.Ala279SerVAR_032854rs35882952
16EPHB2p.Val650AlaVAR_032855rs142173175
17EPHB2p.His679AsnVAR_032856
18EPHB2p.Met883ValVAR_032857
19EPHB2p.Ile909MetVAR_032858
20MXI1p.Glu152AlaVAR_004499
21PTENp.Met134LeuVAR_007469

Clinvar genetic disease variations for Prostate Cancer, Progression of:

6 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1MSR1NM_138715.2(MSR1): c.877C> T (p.Arg293Ter)single nucleotide variantPathogenicrs41341748GRCh37Chr 8, 16012594: 16012594
2MSR1NM_138715.2(MSR1): c.520G> T (p.Asp174Tyr)single nucleotide variantPathogenicrs72552387GRCh37Chr 8, 16026077: 16026077
3ZFHX3ZFHX3, 24-BP DEL, NT10814deletionPathogenic
4BRCA2BRCA2, 1-BP DEL, 6051AdeletionPathogenic
5BRCA2BRCA2, 1-BP INS, 2558AinsertionPathogenic
6MXI1MXI1, 1-BP DEL, A, CODON 140 OR 141deletionPathogenic
7MXI1NM_130439.3(MXI1): c.552+2T> Csingle nucleotide variantPathogenicrs387906417GRCh37Chr 10, 112039054: 112039054
8MXI1NM_130439.3(MXI1): c.656A> C (p.Glu219Ala)single nucleotide variantPathogenicrs137852603GRCh37Chr 10, 112039775: 112039775
9ARNM_000044.3(AR): c.1943G> A (p.Ser648Asn)single nucleotide variantPathogenicrs137852584GRCh37Chr X, 66931301: 66931301
10ARNM_000044.3(AR): c.2191G> A (p.Val731Met)single nucleotide variantPathogenicrs137852571GRCh37Chr X, 66937337: 66937337
11ARNM_000044.3(AR): c.2632A> G (p.Thr878Ala)single nucleotide variantPathogenicrs137852578GRCh37Chr X, 66943552: 66943552
12ARNM_000044.3(AR): c.2633C> G (p.Thr878Ser)single nucleotide variantPathogenicrs137852580GRCh37Chr X, 66943553: 66943553
13ARNM_000044.3(AR): c.2623C> T (p.His875Tyr)single nucleotide variantPathogenicrs137852581GRCh37Chr X, 66943543: 66943543
14ARNM_000044.3(AR): c.2708A> G (p.Gln903Arg)single nucleotide variantPathogenicrs137852582GRCh37Chr X, 66943628: 66943628
15ARNM_000044.3(AR): c.2164G> A (p.Ala722Thr)single nucleotide variantPathogenicrs137852583GRCh37Chr X, 66931522: 66931522

Expression for genes affiliated with Prostate Cancer, Progression of

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Expression patterns in normal tissues for genes affiliated with Prostate Cancer, Progression of

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Pathways for genes affiliated with Prostate Cancer, Progression of

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Pathways related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AR, HIP1
29.5BRCA2, CHEK2
3
Show member pathways
9.5BRCA2, CHEK2
49.5CHEK2, BRCA2
59.3AR, PTEN
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.3AR, PTEN
7
Show member pathways
DNA damage response37
9.1CHEK2, PTEN
89.0EPHB2, PTEN
98.9AR, BRCA2, PTEN
10
Show member pathways
Signaling Pathways in Glioblastoma37
8.9AR, BRCA2, PTEN
11
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
8.8PTEN, CHEK2, AR
128.4AR, CHEK2, BRCA2, PTEN
138.4AR, CHEK2, BRCA2, PTEN

Compounds for genes affiliated with Prostate Cancer, Progression of

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Compounds related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1bicalutamide44 61 1111.6PTEN, AR
2n acetylcysteine449.5CHEK2, MSR1, AR
3diethylstilbestrol44 28 1111.5AR, PTEN
4glutamine449.3BRCA2, AR, HIP1
5indole-3-carbinol449.3PTEN, AR, BRCA2
6hydroxyurea44 50 1111.2CHEK2, BRCA2
7tamoxifen44 50 28 1112.2PTEN, AR, BRCA2
8gemcitabine44 50 1111.1CHEK2, PTEN
9estradiol44 24 1111.1AR, BRCA2, PTEN
10paraffin449.1BRCA2, PTEN, AR
11rapamycin449.1PTEN, AR, CHEK2
12doxorubicin44 50 1111.0PTEN, CHEK2, AR
13cycloheximide448.9BRCA2, AR, PTEN
14testosterone44 61 24 1111.9PTEN, BRCA2, MSR1, AR
15progesterone44 28 61 24 1112.8AR, BRCA2, PTEN
16cisplatin44 50 61 1111.8BRCA2, PTEN, CHEK2
17etoposide44 50 61 1111.7AR, CHEK2, BRCA2, PTEN
18genistein44 28 61 2 24 1113.7BRCA2, PTEN, CHEK2, AR
19phosphatidylinositol448.4CHEK2, EPHB2, BRCA2, PTEN
20retinoic acid44 249.1BRCA2, PTEN, EPHB2, AR, CHEK2
21tyrosine447.9CHEK2, MSR1, EPHB2, PTEN, HIP1

GO Terms for genes affiliated with Prostate Cancer, Progression of

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Cellular components related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:0166058.8CHEK2, PTEN
2nucleusGO:0056347.6AR, MXI1, BRCA2, ZFHX3, PTEN, HIP1

Biological processes related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to gamma radiationGO:0103329.5CHEK2, BRCA2
2double-strand break repairGO:0063029.4BRCA2, CHEK2
3dendritic spine morphogenesisGO:0609979.1EPHB2, PTEN
4protein stabilizationGO:0508219.1CHEK2, PTEN
5negative regulation of axonogenesisGO:0507719.1EPHB2, PTEN
6positive regulation of transcription, DNA-templatedGO:0458938.9AR, CHEK2, BRCA2

Molecular functions related to Prostate Cancer, Progression of according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198998.6AR, ZFHX3, PTEN
2protein bindingGO:0055156.9PTEN, BRCA2, EPHB2, CHEK2, MSR1, AR

Products for genes affiliated with Prostate Cancer, Progression of

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  • Antibodies
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Sources for Prostate Cancer, Progression of

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet