MCID: PRS008
MIFTS: 25

Prostate Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Prostate Small Cell Carcinoma

MalaCards integrated aliases for Prostate Small Cell Carcinoma:

Name: Prostate Small Cell Carcinoma 12 14
Small Cell Carcinoma of Prostate 12 69
Prostate Oat Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7141
NCIt 46 C6766
SNOMED-CT 64 396198006
UMLS 69 C1300585

Summaries for Prostate Small Cell Carcinoma

MalaCards based summary : Prostate Small Cell Carcinoma, also known as small cell carcinoma of prostate, is related to small cell carcinoma and prostatitis. An important gene associated with Prostate Small Cell Carcinoma is SV2B (Synaptic Vesicle Glycoprotein 2B). The drugs Olaparib and Cediranib have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and brain, and related phenotypes are Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor) and taste/olfaction

Related Diseases for Prostate Small Cell Carcinoma

Graphical network of the top 20 diseases related to Prostate Small Cell Carcinoma:



Diseases related to Prostate Small Cell Carcinoma

Symptoms & Phenotypes for Prostate Small Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Small Cell Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor) GR00198-A-1 8.62 ASCL1 AURKA

MGI Mouse Phenotypes related to Prostate Small Cell Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 ASCL1 ENO2

Drugs & Therapeutics for Prostate Small Cell Carcinoma

Drugs for Prostate Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olaparib Approved Phase 2 763113-22-0 23725625
2
Cediranib Investigational Phase 2 288383-20-0 9933475
3 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
4 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Olaparib With or Without Cediranib in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Recruiting NCT02893917 Phase 2 Cediranib;Olaparib

Search NIH Clinical Center for Prostate Small Cell Carcinoma

Genetic Tests for Prostate Small Cell Carcinoma

Anatomical Context for Prostate Small Cell Carcinoma

MalaCards organs/tissues related to Prostate Small Cell Carcinoma:

38
Prostate, Skin, Brain

Publications for Prostate Small Cell Carcinoma

Articles related to Prostate Small Cell Carcinoma:

(show all 19)
# Title Authors Year
1
Solitary Spinal Epidural Metastasis from Prostatic Small Cell Carcinoma. ( 27413569 )
2016
2
Overlap of CD44 expression between prostatic small cell carcinoma and acinar adenocarcinoma. ( 25656929 )
2015
3
Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas. ( 26246306 )
2015
4
Increased androgen receptor gene copy number is associated with TMPRSS2-ERG rearrangement in prostatic small cell carcinoma. ( 24777847 )
2015
5
Frequent TMPRSS2-ERG rearrangement in prostatic small cell carcinoma detected by fluorescence in situ hybridization: the superiority of fluorescence in situ hybridization over ERG immunohistochemistry. ( 23850495 )
2013
6
Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway. ( 22389383 )
2012
7
Re: PC3 is a cell line characteristic of prostatic small cell carcinoma. ( 22682868 )
2012
8
ERG gene rearrangements are common in prostatic small cell carcinomas. ( 21336263 )
2011
9
ERG-TMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin. ( 21499238 )
2011
10
PC3 is a cell line characteristic of prostatic small cell carcinoma. ( 21432867 )
2011
11
CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. ( 18835619 )
2009
12
[Clinicopathological characterization of prostatic small cell carcinoma: a case report and review of the literature]. ( 19947569 )
2009
13
Irradiation enhances the metastatic potential of prostatic small cell carcinoma xenografts. ( 18247403 )
2008
14
Prostate small cell carcinoma and skin metastases: a rare entity. ( 18408396 )
2008
15
Submandibular area metastasis from prostate small cell carcinoma with neuroendocrine differentiation. ( 17912103 )
2007
16
Establishment of a prostatic small-cell carcinoma cell line (SO-MI). ( 12772193 )
2003
17
Brain metastasis from prostate small cell carcinoma: not to be neglected. ( 12463494 )
2002
18
[A case of prostatic small cell carcinoma]. ( 10934615 )
2000
19
WISH-PC2: a unique xenograft model of human prostatic small cell carcinoma. ( 11118033 )
2000

Variations for Prostate Small Cell Carcinoma

Cosmic variations for Prostate Small Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10889 TP53 prostate,NS,carcinoma,small cell carcinoma c.536A>G p.H179R 11
2 COSM938 RB1 prostate,NS,carcinoma,small cell carcinoma c.967G>T p.E323* 11
3 COSM3738526 FOXA1 prostate,NS,carcinoma,small cell carcinoma c.655C>A p.R219S 11

Expression for Prostate Small Cell Carcinoma

Search GEO for disease gene expression data for Prostate Small Cell Carcinoma.

Pathways for Prostate Small Cell Carcinoma

GO Terms for Prostate Small Cell Carcinoma

Sources for Prostate Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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