MCID: PRS004
MIFTS: 27

Prostate Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Prostate Squamous Cell Carcinoma

MalaCards integrated aliases for Prostate Squamous Cell Carcinoma:

Name: Prostate Squamous Cell Carcinoma 12 14
Squamous Cell Carcinoma of Prostate 12 69
Squamous Cell Carcinoma of the Prostate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10287
NCIt 46 C5536
SNOMED-CT 64 399590005
UMLS 69 C1302530

Summaries for Prostate Squamous Cell Carcinoma

MalaCards based summary : Prostate Squamous Cell Carcinoma, also known as squamous cell carcinoma of prostate, is related to prostatic cyst and prostate lymphoma. An important gene associated with Prostate Squamous Cell Carcinoma is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include prostate, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Prostate Squamous Cell Carcinoma

Diseases related to Prostate Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 prostatic cyst 10.4 KLK3 SMUG1
2 prostate lymphoma 10.4 KLK3 SMUG1
3 odontoma 10.4 KRT5 KRT8
4 prostate signet ring cell adenocarcinoma 10.3 CEACAM5 KLK3
5 female urethral cancer 10.3 CEACAM5 KLK3
6 schneiderian carcinoma 10.3 KRT5 SMUG1
7 rete testis adenocarcinoma 10.3 CEACAM5 KLK3
8 urethral benign neoplasm 10.3 CEACAM5 KLK3
9 rete testis neoplasm 10.3 CEACAM5 KLK3
10 esophageal adenosquamous carcinoma 10.3 CEACAM5 KRT5
11 pleural cancer 10.3 KRT5 SMUG1
12 pre-malignant neoplasm 10.3 KRT5 KRT8
13 breast squamous cell carcinoma 10.3 CEACAM5 KRT5
14 liver lymphoma 10.3 CEACAM5 SMUG1
15 seminal vesicle adenocarcinoma 10.3 KLK3 KRT7
16 gallbladder squamous cell carcinoma 10.3 CEACAM5 SMUG1
17 splenic tuberculosis 10.3 CEACAM5 SMUG1
18 bladder adenocarcinoma 10.2 KLK3 KRT7
19 proliferating trichilemmal cyst 10.2 KRT7 KRT8
20 tolosa-hunt syndrome 10.2 CEACAM5 SMUG1
21 endolymphatic sac tumor 10.2 KRT7 KRT8
22 nephrogenic adenoma 10.2 KLK3 KRT7
23 gastric signet ring cell adenocarcinoma 10.2 CEACAM5 SMUG1
24 hidrocystoma 10.2 KRT7 KRT8
25 seminal vesicle tumor 10.2 KLK3 KRT7
26 femoral neuropathy 10.2 CEACAM5 SMUG1
27 descending colon cancer 10.2 CEACAM5 SMUG1
28 nasal cavity cancer 10.2 KRT7 KRT8
29 pericardial tuberculosis 10.2 CEACAM5 SMUG1
30 inverted transitional papilloma 10.2 KRT5 KRT7
31 balloon cell malignant melanoma 10.2 KRT5 KRT7
32 benign breast adenomyoepithelioma 10.2 KRT5 KRT7
33 brooke-spiegler syndrome 10.2 KRT7 KRT8
34 urethral diverticulum 10.2 KLK3 KRT7
35 sensory organ benign neoplasm 10.2 KRT5 KRT7
36 middle ear adenoma 10.2 KRT5 KRT7
37 large cell acanthoma 10.2 KRT5 KRT7
38 tuberculous peritonitis 10.2 CEACAM5 SMUG1
39 papillary adenoma 10.2 KRT5 KRT7
40 pleomorphic carcinoma 10.2 KRT7 KRT8
41 endodermal sinus tumor 10.2 KLK3 KRT7
42 mucinous tubular and spindle renal cell carcinoma 10.2 KRT7 KRT8
43 apocrine adenocarcinoma 10.2 KRT5 KRT7
44 fibrolamellar carcinoma 10.2 KRT7 KRT8
45 breast metaplastic carcinoma 10.2 CEACAM5 KRT5
46 tracheal cancer 10.2 CEACAM5 SMUG1
47 extraosseous osteosarcoma 10.2 KRT7 SMUG1
48 basaloid squamous cell carcinoma 10.2 KRT7 KRT8
49 gastric tubular adenocarcinoma 10.2 KRT7 KRT8
50 lipoadenoma 10.2 KRT5 KRT7

Graphical network of the top 20 diseases related to Prostate Squamous Cell Carcinoma:



Diseases related to Prostate Squamous Cell Carcinoma

Symptoms & Phenotypes for Prostate Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

25 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.77 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.77 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.77 KRT5 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.77 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.77 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.77 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.77 KRT5 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.77 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.77 KRT5 KRT7
10 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.55 HLA-A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.55 HLA-A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.55 HLA-A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.55 KRT8
14 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.55 KRT8 KRT7
15 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.55 HLA-A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.55 HLA-A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.55 HLA-A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.55 KRT8 KRT7
19 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.55 HLA-A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.55 KRT8
21 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.55 HLA-A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.55 KRT8 HLA-A KRT7

Drugs & Therapeutics for Prostate Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Prostate Squamous Cell Carcinoma

Genetic Tests for Prostate Squamous Cell Carcinoma

Anatomical Context for Prostate Squamous Cell Carcinoma

MalaCards organs/tissues related to Prostate Squamous Cell Carcinoma:

38
Prostate

Publications for Prostate Squamous Cell Carcinoma

Articles related to Prostate Squamous Cell Carcinoma:

# Title Authors Year
1
Primary squamous cell carcinoma of the prostate. ( 11020062 )
2000

Variations for Prostate Squamous Cell Carcinoma

Expression for Prostate Squamous Cell Carcinoma

Search GEO for disease gene expression data for Prostate Squamous Cell Carcinoma.

Pathways for Prostate Squamous Cell Carcinoma

Pathways related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.92 KRT5 KRT7 KRT8
2
Show member pathways
11.79 KRT5 KRT7 KRT8
3
Show member pathways
11.11 B2M HLA-A
4
Show member pathways
10.83 KRT5 KRT7 KRT8
5 10.35 B2M HLA-A

GO Terms for Prostate Squamous Cell Carcinoma

Cellular components related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.43 KRT5 KRT7 KRT8
2 ER to Golgi transport vesicle membrane GO:0012507 9.32 B2M HLA-A
3 extracellular exosome GO:0070062 9.17 B2M CEACAM5 HLA-A KLK3 KRT5 KRT7
4 MHC class I protein complex GO:0042612 9.16 B2M HLA-A
5 keratin filament GO:0045095 9.13 KRT5 KRT7 KRT8

Biological processes related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.33 KRT5 KRT7 KRT8
2 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.26 B2M HLA-A
3 cornification GO:0070268 9.13 KRT5 KRT7 KRT8
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.62 B2M HLA-A

Molecular functions related to Prostate Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT5 KRT8

Sources for Prostate Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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