MCID: PRS045
MIFTS: 44

Prostatic Hypertrophy malady

Summaries for Prostatic Hypertrophy

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Benign prostatic hyperplasia (BPH), also called benign enlargement of the prostate (BEP),... more...

MalaCards: Prostatic Hypertrophy, also known as benign prostatic hypertrophy, is related to prostatitis and prostate cancer. An important gene associated with Prostatic Hypertrophy is SRY (sex determining region Y), and among its related pathways is Cell death signalling via NRAGE, NRIF and NADE. The compounds tamsulosin and chlormadinone acetate have been mentioned in the context of this disorder. Affiliated tissues include prostate, heart and breast.

Aliases & Classifications for Prostatic Hypertrophy

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS
See all sources

Aliases & Descriptions:

prostatic hypertrophy 8 10
benign prostatic hypertrophy 60


External Ids:

Disease Ontology8 DOID:11132

Related Diseases for Prostatic Hypertrophy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Prostatic Hypertrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis32.0SRD5A1, ACPP, PROS1, PDE5A, KLK3
2prostate cancer31.1KLK3, ACPP, SRD5A1, GSTP1
3prostate disease30.7SRD5A1, ACPP, CYP19A1, KLK3
4prostatic adenoma30.3KLK3, ACPP, SRD5A1
5adenoma30.3SHBG, PCNA, F2RL1, ACPP, SRD5A1, GSTP1
6urinary tract obstruction30.2KLK3, SRD5A1
7hypertension30.2PDE5A, PROS1, ADRA1D
8adenocarcinoma30.2KLK3, PROS1, PCNA, F2RL1, ACPP, SRD5A1
9urethral stricture30.0KLK3
10sexual disorder30.0KLK3, PDE5A, SHBG
11klinefelter's syndrome30.0SHBG, CYP19A1, FGF8, SRD5A1
12diabetes mellitus30.0PDE5A, PROS1, SHBG
13hypogonadism30.0KLK3, PDE5A, SHBG, CYP19A1, FGF8
14urethritis10.5
15neurogenic bladder10.2
16prostate lymphoma10.2
17acute myocardial infarction10.2
18myocardial infarction10.2
19prostate adenocarcinoma10.2
20testicular cancer10.2
21urethral obstruction10.2
22nephrogenic adenoma10.0
23prolactinoma10.0
24prostate leiomyoma10.0
25bladder neck obstruction10.0
26osteoarthritis10.0
27acute pyelonephritis10.0
28kidney hypertrophy10.0
29adrenal carcinoma10.0
30acute kidney failure10.0
31bladder disease10.0
32cataract10.0
33chronic kidney failure10.0
34chronic pyelonephritis10.0
35conjunctivitis10.0
36diabetic neuropathy10.0
37hypertrophy of breast10.0
38ischemic heart disease10.0
39kidney disease10.0
40leiomyoma10.0
41neuropathy10.0
42prostatic urethral cancer10.0
43pyelonephritis10.0
44uterine disease10.0
45hermaphroditism10.0SRY
46gonadal dysgenesis10.0SRY
47gastroparesis10.0PHF20
48hypoactive sexual desire disorder10.0SHBG
49periodontal disease10.0ACPP
5046xx sex reversal 110.0SRY, SRD5A1

Graphical network of the top 20 diseases related to Prostatic Hypertrophy:



Diseases related to prostatic hypertrophy

Clinical Features for Prostatic Hypertrophy

About this section

Drugs & Therapeutics for Prostatic Hypertrophy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Prostatic Hypertrophy

Drug clinical trials:

Search ClinicalTrials for Prostatic Hypertrophy

Search NIH Clinical Center for Prostatic Hypertrophy

Search CenterWatch for Prostatic Hypertrophy

Genetic Tests for Prostatic Hypertrophy

About this section

Anatomical Context for Prostatic Hypertrophy

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Prostatic Hypertrophy:

32
Prostate, Heart, Breast, Bone, Kidney, Smooth muscle, Colon, Appendix

Animal Models for Prostatic Hypertrophy or affiliated genes

About this section

Publications for Prostatic Hypertrophy

About this section
Sources:
50PubMed
See all sources

Articles related to Prostatic Hypertrophy:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Benign prostatic hypertrophy: update on drug therapy. (17279217)
2006
2
Estradiol/androgen receptors during aging: microsomal distribution in human benign prostatic hypertrophy. (15764417)
2005
3
Interstitial laser photocoagulation for treatment of benign prostatic hypertrophy: outcomes and cost effectiveness. (14765749)
2003
4
Urethral reconstruction of strictures resulting from treatment of benign prostatic hypertrophy and prostate cancer. (12371233)
2002
5
Correlation between androgen receptor expression and FGF8 mRNA levels in patients with prostate cancer and benign prostatic hypertrophy. (10343609)
1999
6
Theriogenology question of the month. Benign prostatic hypertrophy (BPH), prostatitis, and prostatic neoplasia. (9743718)
1998
7
Electrovaporization of the prostate versus laser ablation of the prostate in men with benign prostatic hypertrophy: a pressure-flow analysis. (9701735)
1998
8
Phenol injection for benign prostatic hypertrophy. (9594679)
1998
9
Developments in the use of lasers for the treatment of benign prostatic hypertrophy. (16160984)
1997
10
Transition zone ratio and prostate-specific antigen density: the index of response of benign prostatic hypertrophy to an alpha blocker. (8886912)
1996
11
Objective noninvasive evaluation of benign prostatic hypertrophy. (7535622)
1995
12
An analysis of the costs of alternative treatments for benign prostatic hypertrophy. (8544151)
1995
13
Benign prostatic hypertrophy affects the endothelin receptor density in the human urinary bladder and prostate. (7541922)
1995
14
Alpha blocker prazosin for the treatment of benign prostatic hypertrophy (BPH). (10707729)
1995
15
Re: Risk factors for benign prostatic hypertrophy. (7507639)
1994
16
Analysis of the low affinity high capacity estrogenic binding in human benign prostatic hypertrophy. (7509256)
1993
17
Criterion validation of the Nottingham Health Profile: patient views of surgery for benign prostatic hypertrophy. (7687383)
1993
18
Ratio of serum tartrate-inhibitable acid phosphatase to total serum protein in benign prostatic hypertrophy and prostatic carcinoma. (1371723)
1992
19
Laboratory monitoring of androgenic activity in benign prostate hypertrophy treated with a 5 alpha-reductase inhibitor. (1377994)
1992
20
Mortality, morbidity and complications following transurethral resection of the prostate for benign prostatic hypertrophy. (1375662)
1992
21
Prevalence of benign prostatic hypertrophy. (1717803)
1991
22
Prostatic hypertrophy in the elderly cirrhotic patient: an estrogenic or androgenic response? (2461893)
1989
23
Texture analysis--a new method of differentiating prostatic carcinoma from prostatic hypertrophy. (2462297)
1988
24
Prostatectomy or conservative management in the treatment of benign prostatic hypertrophy? (2456121)
1988
25
The effect of bromocriptine in benign prostatic hypertrophy and vesicosphincteric dynamics. (2444307)
1987
26
Circulating levels of inhibin, prolactin, TSH, LH, and FSH in benign prostatic hypertrophy before and after tumor resection. (2436203)
1987
27
Alpha-1 adrenoceptors in human prostate: characterization and alteration in benign prostatic hypertrophy. (2441028)
1987
28
Peripheral and prostatic vein steroid concentrations in benign prostatic hypertrophy patients before and after removal of the adenoma. (6163202)
1980
29
Total and SHBG-bound testosterone and 5 alpha-dihydrotestosterone serum concentrations in normal elderly men and patients with benign prostatic hypertrophy before and after removal of the adenoma. (6159037)
1980
30
Plasma steroid and protein hormone concentrations in patients with benign prostatic hypertrophy and in normal men. (89045)
1979
31
Occult progressive renal damage in the elderly male due to benign prostatic hypertrophy. (89133)
1979
32
Free amino acids and ninhydrin-reacting compounds of median and lateral lobes in human benign prostatic hypertrophy. (86445)
1979
33
Inhibition by various steroids on dihydrotestosterone binding to androphilic protein in human benign prostatic hypertrophy. (84756)
1978
34
Urodynamics in benign prostatic hypertrophy. (75752)
1978
35
Using antiandrogen therapy in benign prostatic hypertrophy. (66171)
1977
36
Intracellular localisation of 5alpha-dihydrotestosterone in human benign prostatic hypertrophy. (63340)
1976
37
Detrusor and urethral dysfunction in prostatic hypertrophy. (64268)
1976
38
Palliative effect of gelatine in benign prostatic hypertrophy. (4122645)
1973
39
Treatment of benign prostatic hypertrophy with medrogestone. (4105445)
1971
40
The effect of 17-alpha-hydroxy-19-norprogesterone caproate (SH582) on benign prostatic hypertrophy. (4105896)
1971
41
Cystic prostatic hypertrophy in 2 inbred lines of Syrian hamsters. (4192990)
1970
42
Serum sodium and chloride in prostatic hypertrophy and cancer. (4193657)
1970
43
VOIDING PRESSURE AND URINARY FLOW IN PROSTATIC HYPERTROPHY AND IN NEUROGENIC BLADDER DISORDERS. (14227133)
1964
44
THE CLINICAL APPLICATION OF VASO-SEMINAL VESICULOGRAPHY IN DIFFERENTIAL DIAGNOSIS OF PROSTATIC HYPERTROPHY AND CANCER. (14042597)
1963
45
Benign prostatic hypertrophy: amino acid therapy for symptomatic relief. (13883328)
1962
46
Obstructive uropathy due to prostatic hypertrophy. (13743292)
1960
47
Effect of prednisone (meticorten) on benign prostatic hypertrophy. (13831816)
1960
48
Urethrograms in the diagnosis and management of benign prostatic hypertrophy. (13665062)
1959
49
Treatment of benign prostatic hypertrophy with estrogen administered intravenously. (13462711)
1957
50
Prostatic hypertrophy: choice of operation; a review of personal experience. (13383420)
1957

Genetic Variations for Prostatic Hypertrophy

About this section

Expression for genes affiliated with Prostatic Hypertrophy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Prostatic Hypertrophy

Search GEO for disease gene expression data for Prostatic Hypertrophy.

Pathways for genes affiliated with Prostatic Hypertrophy

About this section
Sources:
53Reactome
See all sources

Pathways related to Prostatic Hypertrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ADRA1A, ADRA1D

Compounds for genes affiliated with Prostatic Hypertrophy

About this section
Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Prostatic Hypertrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1tamsulosin28 44 1112.5KLK3, ADRA1D, ADRA1A
2chlormadinone acetate4410.4ACPP, SHBG, KLK3
3atrazine4410.4SHBG, KLK3, CYP19A1
4dutasteride44 1111.4CYP19A1, SRD5A1, KLK3
5formestane4410.4SRD5A1, SHBG, CYP19A1
6estramustine phosphate4410.4KLK3, PROS1, ACPP
7epinephrine44 11 2412.4SHBG, ADRA1D, ADRA1A
8ment4410.3SRD5A1, KLK3, CYP19A1, SHBG
9androstenediol4410.3KLK3, SHBG, CYP19A1, SRD5A1
10alfuzosin44 1111.3ADRA1D, KLK3, SRD5A1, ADRA1A
11megestrol acetate4410.3CYP19A1, KLK3, SHBG
12terazosin44 1111.3ADRA1D, ADRA1A, SRD5A1, KLK3
13doxazosin44 1111.3ADRA1D, KLK3, SRD5A1, ADRA1A
14bicalutamide44 59 1112.3KLK3, SRD5A1, ACPP, CYP19A1
155alpha-androstane-3alpha,17beta-diol4410.2SHBG, CYP19A1, SRD5A1
1617-hydroxyprogesterone44 2411.2CYP19A1, SRD5A1, SHBG, ACPP
17hydroxyflutamide44 2811.2KLK3, SRD5A1, SHBG
18lycopene44 2411.2SRD5A1, GSTP1, KLK3, PCNA
19diethylstilbestrol44 28 1112.2KLK3, SHBG, CYP19A1, ACPP
20ketoconazole44 28 11 2413.2KLK3, SHBG, CYP19A1, SRD5A1
21progestins4410.2KLK3, SHBG, CYP19A1, SRD5A1
22finasteride44 59 11 2413.2ACPP, KLK3, SHBG, SRD5A1, CYP19A1
23cyproteroneacetate4410.2CYP19A1, SRD5A1, KLK3, ACPP, SHBG
24deoxyribonucleic acid4410.2ACPP, SRY, PCNA, KLK3
25buserelin44 28 1112.1CYP19A1, KLK3, ACPP
26flutamide44 59 1112.1SHBG, KLK3, ACPP, SRD5A1, CYP19A1
27phentolamine28 44 1112.1ADRA1D, ADRA1A, PDE5A
28dehydroepiandrosterone sulfate4410.1SRD5A1, CYP19A1, SHBG, KLK3, ACPP
29dhea4410.1SRD5A1, ACPP, SHBG, KLK3, CYP19A1
30bromocriptine28 44 1112.1SHBG, ADRA1A, ADRA1D, PCNA
31leuprolide acetate4410.1KLK3, SHBG, CYP19A1
32biotin44 11 2412.1SRY, GSTP1, KLK3, SHBG, PCNA
33docetaxel44 49 59 1113.1KLK3, TUBD1, GSTP1, PROS1, CYP19A1
34estrogen4410.1KLK3, PDE5A, ACPP, SRD5A1
35estramustine44 1111.0PROS1, ACPP, KLK3
363-alpha-androstanediol glucuronide44 2411.0SHBG, KLK3, SRD5A1
37goserelin44 28 1112.0PROS1, ACPP, SHBG, KLK3, CYP19A1, SRD5A1
38dexamethasone44 49 28 1113.0PROS1, KLK3, SHBG, PCNA
39vitamin d449.9PROS1, SRD5A1, ACPP, CYP19A1, SHBG, KLK3
40dihydrotestosterone44 28 11 2412.9SRD5A1, ACPP, CYP19A1, SHBG, PROS1, KLK3
41gnrh449.9KLK3, SRD5A1, ACPP, CYP19A1, SHBG
42genistein44 28 59 2 11 2414.8F2RL1, CYP19A1, GSTP1, SHBG, SRD5A1, PCNA
43androstenedione44 2410.7SRD5A1, ACPP, SHBG, CYP19A1
44dopamine44 28 11 2412.7GSTP1, SRD5A1, F2RL1, FGF8, PCNA, SHBG
45steroid449.7CYP19A1, KLK3, PROS1, SHBG, ACPP, SRY
46exemestane49 44 59 1112.7CYP19A1, SHBG, SRD5A1
47estradiol44 11 2411.7KLK3, PCNA, SRY, ACPP, SHBG, SRD5A1
48vegf449.5GSTP1, F2RL1, PDE5A, ACPP, PCNA, KLK3
49arginine449.5F2RL1, ACPP, GSTP1, CYP19A1, PCNA, PROS1
50testosterone44 59 11 2412.2CYP19A1, SRD5A1, PCNA, SRY, ACPP, GSTP1

GO Terms for genes affiliated with Prostatic Hypertrophy

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Prostatic Hypertrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressureGO:00199410.2ADRA1A, ADRA1D
2negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.1GSTP1, F2RL1
3leukocyte migrationGO:05090010.0F2RL1, SIRPA, PROS1
4positive regulation of superoxide anion generationGO:0329309.9GSTP1, F2RL1

Molecular functions related to Prostatic Hypertrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alpha1-adrenergic receptor activityGO:00493710.2ADRA1A, ADRA1D

Products for genes affiliated with Prostatic Hypertrophy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostatic Hypertrophy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet