MCID: PRS045
MIFTS: 44

Prostatic Hypertrophy malady

Summaries for Prostatic Hypertrophy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Benign prostatic hyperplasia (BPH), also called benign enlargement of the prostate (BEP),... more...

MalaCards: Prostatic Hypertrophy, also known as benign prostatic hypertrophy, is related to prostatitis and prostate cancer. An important gene associated with Prostatic Hypertrophy is SRY (sex determining region Y), and among its related pathways is Cell death signalling via NRAGE, NRIF and NADE. The compounds tamsulosin and chlormadinone acetate have been mentioned in the context of this disorder. Affiliated tissues include prostate, heart and breast.

Aliases & Classifications for Prostatic Hypertrophy

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8Disease Ontology, 10DISEASES, 60UMLS
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Aliases & Descriptions:

prostatic hypertrophy 8 10
benign prostatic hypertrophy 60


External Ids:

Disease Ontology8 DOID:11132

Related Diseases for Prostatic Hypertrophy

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17GeneCards, 18GeneDecks
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Diseases related to Prostatic Hypertrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis32.0SRD5A1, ACPP, PROS1, PDE5A, KLK3
2prostate cancer31.1KLK3, ACPP, SRD5A1, GSTP1
3prostate disease30.7SRD5A1, ACPP, CYP19A1, KLK3
4prostatic adenoma30.3KLK3, ACPP, SRD5A1
5adenoma30.3SHBG, PCNA, F2RL1, ACPP, SRD5A1, GSTP1
6urinary tract obstruction30.2KLK3, SRD5A1
7hypertension30.2PDE5A, PROS1, ADRA1D
8adenocarcinoma30.2KLK3, PROS1, PCNA, F2RL1, ACPP, SRD5A1
9urethral stricture30.0KLK3
10sexual disorder30.0KLK3, PDE5A, SHBG
11klinefelter's syndrome30.0SHBG, CYP19A1, FGF8, SRD5A1
12diabetes mellitus30.0PDE5A, PROS1, SHBG
13hypogonadism30.0KLK3, PDE5A, SHBG, CYP19A1, FGF8
14urethritis10.5
15neurogenic bladder10.2
16prostate lymphoma10.2
17acute myocardial infarction10.2
18myocardial infarction10.2
19prostate adenocarcinoma10.2
20testicular cancer10.2
21urethral obstruction10.2
22nephrogenic adenoma10.0
23prolactinoma10.0
24prostate leiomyoma10.0
25bladder neck obstruction10.0
26osteoarthritis10.0
27acute pyelonephritis10.0
28kidney hypertrophy10.0
29adrenal carcinoma10.0
30acute kidney failure10.0
31bladder disease10.0
32cataract10.0
33chronic kidney failure10.0
34chronic pyelonephritis10.0
35conjunctivitis10.0
36diabetic neuropathy10.0
37hypertrophy of breast10.0
38ischemic heart disease10.0
39kidney disease10.0
40leiomyoma10.0
41neuropathy10.0
42prostatic urethral cancer10.0
43pyelonephritis10.0
44uterine disease10.0
45hermaphroditism10.0SRY
46gonadal dysgenesis10.0SRY
47gastroparesis10.0PHF20
48hypoactive sexual desire disorder10.0SHBG
49periodontal disease10.0ACPP
5046xx sex reversal 110.0SRY, SRD5A1

Graphical network of the top 20 diseases related to Prostatic Hypertrophy:



Diseases related to prostatic hypertrophy

Clinical Features for Prostatic Hypertrophy

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Drugs & Therapeutics for Prostatic Hypertrophy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Prostatic Hypertrophy

Drug clinical trials:

Search ClinicalTrials for Prostatic Hypertrophy

Search NIH Clinical Center for Prostatic Hypertrophy

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Genetic Tests for Prostatic Hypertrophy

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Anatomical Context for Prostatic Hypertrophy

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32MalaCards
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MalaCards organs/tissues related to Prostatic Hypertrophy:

32
Prostate, Heart, Breast, Bone, Kidney, Smooth muscle, Colon, Appendix

Animal Models for Prostatic Hypertrophy or affiliated genes

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Publications for Prostatic Hypertrophy

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50PubMed
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Articles related to Prostatic Hypertrophy:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Constitutional, organopathic and combined homeopathic treatment of benign prostatic hypertrophy: a clinical trial. (23089217)
2012
2
Tamsulosin oral controlled absorption system (OCAS) in the treatment of benign prostatic hypertrophy. (18728700)
2008
3
Should patients with benign prostatic hypertrophy stop taking doxazosin in the light of the ALLHAT study? (16412808)
2006
4
Deep vein thrombosis associated with distension of the urinary bladder due to benign prostatic hypertrophy--a case report. (15255085)
2004
5
Finasteride and tamsulosin used in benign prostatic hypertrophy: a review of the prescription-event monitoring data. (11412215)
2001
6
Men's lived experiences following transurethral prostatectomy for benign prostatic hypertrophy. (10632793)
2000
7
Prostate specific antigen measurements after minimally invasive surgery of the prostate in men with benign prostatic hypertrophy. (12497098)
2000
8
Alpha1-adrenoceptors in testosterone-induced prostatic hypertrophy. (9489864)
1998
9
Benign prostatic hypertrophy. (9174812)
1997
10
Safety profile of 3 months' therapy with alfuzosin in 13,389 patients suffering from benign prostatic hypertrophy. (8821687)
1996
11
Use of recombinant alpha 1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy. (7536677)
1995
12
Flavoxate treatment of micturition disorders accompanying benign prostatic hypertrophy: a double-blind placebo-controlled multicenter investigation. (8588267)
1995
13
Clinical research criteria: response criteria for evaluating efficacy of treatments for benign prostatic hypertrophy. (7544218)
1995
14
Transurethral radiotherapy for benign prostatic hypertrophy-related urethral obstruction. Dosimetry, ethics, and preliminary results. (7522461)
1994
15
Tissue polypeptide-specific antigen: a discriminative parameter between prostate cancer and benign prostatic hypertrophy. (7679580)
1993
16
Predictive factors for successful surgical outcome of benign prostatic hypertrophy. (7689968)
1993
17
Re: The role of urodynamic investigation in the assessment of benign prostatic hypertrophy. (7685423)
1993
18
The role of urodynamic investigation in the assessment of benign prostatic hypertrophy. (1383572)
1992
19
Prostatic growth factors and benign hypertrophy of the prostate. Current knowledge and perspectives]. (1284554)
1992
20
Subjective and clinical results after transurethral resection and suprapubic prostatectomy in benign prostatic hypertrophy. (1726084)
1991
21
Benign prostatic hypertrophy. (1711771)
1991
22
Benign prostatic hypertrophy. (1725588)
1991
23
Urophonographic studies of benign prostatic hypertrophy. (1707988)
1991
24
Re: Bladder outflow tract obstruction and urinary retention from benign prostatic hypertrophy treated by balloon dilatation. (1699630)
1990
25
Effects of an alpha 1-adrenergic blocker (prazosin HCl) on micturition disturbances associated with benign prostatic hypertrophy. (1690479)
1990
26
Controlled study of cimetidine in the treatment of benign prostatic hypertrophy. (1697490)
1990
27
Benign prostatic hypertrophy: treatment with a metallic stent. (2476008)
1989
28
Urethroplasty with balloon catheter in prostatic hypertrophy. (2440290)
1987
29
Local hyperthermia of the prostate gland for the treatment of benign prostatic hypertrophy and urinary retention. A preliminary report. (2447996)
1987
30
Urogastrone-epidermal growth factor concentrations in prostatic fluid of normal individuals and patients with benign prostatic hypertrophy. (2421962)
1986
31
Induction of benign prostatic hypertrophy in baboons. (6199881)
1984
32
Leucine-arylamidase activity in untreated and treated benign prostatic hypertrophy and adenocarcinomatous prostate. (6172970)
1981
33
Peripelvic urinoma associated with benign prostatic hypertrophy. (92838)
1979
34
Benign prostatic hypertrophy. (85414)
1979
35
Benign prostatic hypertrophy. (80298)
1978
36
Quantification of androgen binding, androgen tissue levels, and sex hormone-binding globulin in prostate, muscle and plasma of patients with benign prostatic hypertrophy. (71838)
1977
37
A clinical and urodynamic study of tadenan in the treatment of benign prostatic hypertrophy. (71995)
1977
38
Megestrol acetate in treatment of benign prostatic hypertrophy. (52933)
1975
39
Urinary dynamics in benign prostatic hypertrophy. (4110711)
1972
40
A double-blind, controlled, clinical trial of spironolactone for benign prostatic hypertrophy. (4104441)
1971
41
Cryosurgery of prostatic hypertrophy. Late results. (4107716)
1971
42
Therapy with progestational agents in advanced benign prostatic hypertrophy. (4187537)
1969
43
From the history of prostatic hypertrophy. A medico-historical investigation of its pathology and palliative surgical treatment up to the beginning of the 20th century. Appendix: from the history of lithotomy. A short survey of the development of the different methods. (4190167)
1969
44
KLINEFELTER'S SYNDROME AND BENIGN PROSTATIC HYPERTROPHY. (14057110)
1963
45
Blood-groups in benign and malignant prostatic hypertrophy. (14014480)
1962
46
Benign prostatic hypertrophy. (13346266)
1956
47
Prostatic hypertrophy (Large subtrigonal lobe--case report). (14384842)
1954
48
Anaerobic glycolysis of human benign prostatic hypertrophy slices: inhibition by testosterone. (13211518)
1954
49
On the hormonal treatment of benign and malign prostatic hypertrophy. (20267138)
1947
50
The Etiology of Benign Prostatic Hypertrophy. (19312562)
1947

Genetic Variations for Prostatic Hypertrophy

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Expression for genes affiliated with Prostatic Hypertrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostatic Hypertrophy

Search GEO for disease gene expression data for Prostatic Hypertrophy.

Pathways for genes affiliated with Prostatic Hypertrophy

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53Reactome
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Pathways related to Prostatic Hypertrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ADRA1A, ADRA1D

Compounds for genes affiliated with Prostatic Hypertrophy

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Prostatic Hypertrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1tamsulosin28 44 1112.5KLK3, ADRA1D, ADRA1A
2chlormadinone acetate4410.4ACPP, SHBG, KLK3
3atrazine4410.4SHBG, KLK3, CYP19A1
4dutasteride44 1111.4CYP19A1, SRD5A1, KLK3
5formestane4410.4SRD5A1, SHBG, CYP19A1
6estramustine phosphate4410.4KLK3, PROS1, ACPP
7epinephrine44 11 2412.4SHBG, ADRA1D, ADRA1A
8ment4410.3SRD5A1, KLK3, CYP19A1, SHBG
9androstenediol4410.3KLK3, SHBG, CYP19A1, SRD5A1
10alfuzosin44 1111.3ADRA1D, KLK3, SRD5A1, ADRA1A
11megestrol acetate4410.3CYP19A1, KLK3, SHBG
12terazosin44 1111.3ADRA1D, ADRA1A, SRD5A1, KLK3
13doxazosin44 1111.3ADRA1D, KLK3, SRD5A1, ADRA1A
14bicalutamide44 59 1112.3KLK3, SRD5A1, ACPP, CYP19A1
155alpha-androstane-3alpha,17beta-diol4410.2SHBG, CYP19A1, SRD5A1
1617-hydroxyprogesterone44 2411.2CYP19A1, SRD5A1, SHBG, ACPP
17hydroxyflutamide44 2811.2KLK3, SRD5A1, SHBG
18lycopene44 2411.2SRD5A1, GSTP1, KLK3, PCNA
19diethylstilbestrol44 28 1112.2KLK3, SHBG, CYP19A1, ACPP
20ketoconazole44 28 11 2413.2KLK3, SHBG, CYP19A1, SRD5A1
21progestins4410.2KLK3, SHBG, CYP19A1, SRD5A1
22finasteride44 59 11 2413.2ACPP, KLK3, SHBG, SRD5A1, CYP19A1
23cyproteroneacetate4410.2CYP19A1, SRD5A1, KLK3, ACPP, SHBG
24deoxyribonucleic acid4410.2ACPP, SRY, PCNA, KLK3
25buserelin44 28 1112.1CYP19A1, KLK3, ACPP
26flutamide44 59 1112.1SHBG, KLK3, ACPP, SRD5A1, CYP19A1
27phentolamine28 44 1112.1ADRA1D, ADRA1A, PDE5A
28dehydroepiandrosterone sulfate4410.1SRD5A1, CYP19A1, SHBG, KLK3, ACPP
29dhea4410.1SRD5A1, ACPP, SHBG, KLK3, CYP19A1
30bromocriptine28 44 1112.1SHBG, ADRA1A, ADRA1D, PCNA
31leuprolide acetate4410.1KLK3, SHBG, CYP19A1
32biotin44 11 2412.1SRY, GSTP1, KLK3, SHBG, PCNA
33docetaxel44 49 59 1113.1KLK3, TUBD1, GSTP1, PROS1, CYP19A1
34estrogen4410.1KLK3, PDE5A, ACPP, SRD5A1
35estramustine44 1111.0PROS1, ACPP, KLK3
363-alpha-androstanediol glucuronide44 2411.0SHBG, KLK3, SRD5A1
37goserelin44 28 1112.0PROS1, ACPP, SHBG, KLK3, CYP19A1, SRD5A1
38dexamethasone44 49 28 1113.0PROS1, KLK3, SHBG, PCNA
39vitamin d449.9PROS1, SRD5A1, ACPP, CYP19A1, SHBG, KLK3
40dihydrotestosterone44 28 11 2412.9SRD5A1, ACPP, CYP19A1, SHBG, PROS1, KLK3
41gnrh449.9KLK3, SRD5A1, ACPP, CYP19A1, SHBG
42genistein44 28 59 2 11 2414.8F2RL1, CYP19A1, GSTP1, SHBG, SRD5A1, PCNA
43androstenedione44 2410.7SRD5A1, ACPP, SHBG, CYP19A1
44dopamine44 28 11 2412.7GSTP1, SRD5A1, F2RL1, FGF8, PCNA, SHBG
45steroid449.7CYP19A1, KLK3, PROS1, SHBG, ACPP, SRY
46exemestane49 44 59 1112.7CYP19A1, SHBG, SRD5A1
47estradiol44 11 2411.7KLK3, PCNA, SRY, ACPP, SHBG, SRD5A1
48vegf449.5GSTP1, F2RL1, PDE5A, ACPP, PCNA, KLK3
49arginine449.5F2RL1, ACPP, GSTP1, CYP19A1, PCNA, PROS1
50testosterone44 59 11 2412.2CYP19A1, SRD5A1, PCNA, SRY, ACPP, GSTP1

GO Terms for genes affiliated with Prostatic Hypertrophy

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16Gene Ontology
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Biological processes related to Prostatic Hypertrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressureGO:00199410.2ADRA1A, ADRA1D
2negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.1GSTP1, F2RL1
3leukocyte migrationGO:05090010.0F2RL1, SIRPA, PROS1
4positive regulation of superoxide anion generationGO:0329309.9GSTP1, F2RL1

Molecular functions related to Prostatic Hypertrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alpha1-adrenergic receptor activityGO:00493710.2ADRA1A, ADRA1D

Products for genes affiliated with Prostatic Hypertrophy

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  • Antibodies
  • Proteins
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Sources for Prostatic Hypertrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet