Summaries for Prostatitis

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Wikipedia:63 Prostatitis (less commonly prostatosis) is inflammation of the prostate gland. Prostatitis is classified... more...

MalaCards based summary: Prostatitis is related to prostate cancer and prostatic hypertrophy. An important gene associated with Prostatitis is KLK3 (kallikrein-related peptidase 3), and among its related pathways are Selected targets of C EBPalpha and Cell adhesion ECM remodeling. The drugs ciprofloxacin and norfloxacin and the compounds provenge and estracyt have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Prostatitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt
See all sources

Prostatitis, Aliases & Descriptions:

Name: Prostatitis 9 11 43 60


External Ids:

Disease Ontology9 DOID:14654
ICD9CM27 601, 601.9
MeSH33 D011472
NCIt38 C26866

Related Diseases for Prostatitis

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Diseases related to Prostatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 635)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer32.6GDF15, PROS1, ACPP, KLK3
2prostatic hypertrophy32.2KLK3, ACPP
3prostate disease31.9KLK3, ACPP
4adenocarcinoma31.8KLK3, ACPP, PROS1, GDF15
5prostatic adenoma31.5KLK3, ACPP
6proctitis31.1KLK3, LTF
7adenoma31.0GDF15, CP, ACPP
8breast cancer30.8GDF15, CP, ACPP, KLK3
9clear cell adenocarcinoma30.7ACPP, KLK3
10pancreatitis30.5LTF, ELANE
11colorectal cancer30.4LTF, PROS1, CP, GDF15
12polyarteritis nodosa30.3LTF
13endometrial cancer30.0KLK3, ACPP
14liver cirrhosis30.0CP, ACPP, LTF
15melanoma29.8LTF, IL8, CP, GDF15
16vasculitis29.8LTF, ELANE, PROS1
17gingivitis29.8ELANE, LTF
18colitis29.7LTF, IL8
19neutropenia29.6KLK3, ELANE, CP
20monocytic leukemia29.6LTF, IL8
21periodontitis29.5LTF, IL8, ELANE
22periodontal disease29.5ELANE, IL8, LTF
23ulcerative colitis29.5LTF, IL8, ELANE
24arthritis29.4LTF, IL8, ACPP
25atherosclerosis29.3IL8, ELANE, CP
26cystic fibrosis29.2CP, ELANE, IL8, LTF
27rheumatoid arthritis28.9CP, ELANE, IL8, LTF
28prostate adenocarcinoma11.2
29endotheliitis10.9
30urethritis10.8
31insulin-like growth factor i10.7
32hypoxia10.7
33small cell carcinoma10.6
34rhabdomyosarcoma10.6
35blindness10.6
36leukemia10.6
37mucinous adenocarcinoma10.5
38obesity10.5
39hypogonadism10.5
40urethral stricture10.5
41prostatic cyst10.5
42malakoplakia10.5
43sarcoma10.5
44neuroendocrine carcinoma10.5
45androgen insensitivity10.5
46prostate rhabdomyosarcoma10.5
47transitional cell carcinoma10.5
48retinoblastoma10.4
49embryonal rhabdomyosarcoma10.4
50prostate small cell carcinoma10.4

Graphical network of the top 20 diseases related to Prostatitis:



Diseases related to prostatitis

Symptoms for Prostatitis

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Drugs & Therapeutics for Prostatitis

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Drug clinical trials:

Search ClinicalTrials for Prostatitis

Search NIH Clinical Center for Prostatitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Prostatitis

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Anatomical Context for Prostatitis

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MalaCards organs/tissues related to Prostatitis:

31
Prostate, Bone, Breast, Endothelial, Testes, Lymph node, Lung, T cells, Colon, Bone marrow, Liver, Pituitary, Smooth muscle, Kidney, Testis, Skin, B cells, Brain, Spinal cord, Heart, Ovary, Monocytes, Myeloid, Placenta, Thyroid, Pancreas, Salivary gland, Nk cells, Neutrophil, Cervix, Adipocyte, Eye, Whole blood, Spleen, Skeletal muscle, Small intestine, Uterus, Hypothalamus, Tongue, Appendix, Pineal

Animal Models for Prostatitis or affiliated genes

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MGI Mouse Phenotypes related to Prostatitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6LTF, PROS1, CP, GDF15
2MP:00053976.8LTF, GDF15, CP, PROS1, ELANE, IL8

Publications for Prostatitis

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Articles related to Prostatitis:

(show top 50)    (show all 18780)
idTitleAuthorsYear
1
Lumican expression, localization and antitumor activity in prostate cancer. (23399832)
2013
2
Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. (23676682)
2013
3
Pre-prostatic tissue removed in robotic assisted lymph node dissection for prostate cancer contains lymph nodes. (24311906)
2013
4
No evidence of FGFR3 mutations in prostate cancer. (20957671)
2011
5
Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. (19820934)
2010
6
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF- kappaB activity in prostate cancer cells. (20068069)
2010
7
CYP17 polymorphisms and prostate cancer outcomes. (20503394)
2010
8
Promising tumor-associated antigens for future prostate cancer therapy. (19536865)
2010
9
Other biomarkers for detecting prostate cancer. (19930175)
2010
10
Y chromosome haplotypes and prostate cancer in Sweden. (18927315)
2008
11
A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. (18703514)
2008
12
Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk: a replication study in an ethnically homogeneous population. (18537123)
2008
13
A common 8q24 variant in prostate and breast cancer from a large nested case-control study. (17409400)
2007
14
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. (17443494)
2007
15
P2Y purinergic receptor activated PI-3K/Akt signaling pathway in regulation of growth and invasion of prostatic cancer]. (18194602)
2007
16
Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer. (16698360)
2006
17
Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer. (16388505)
2006
18
The hidden condition: status, challenges, and opportunities in the management of enlarged prostate for managed care. (16551205)
2006
19
Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells. (17079215)
2006
20
Characterization of frequently deleted 6q locus in prostate cancer. (17132090)
2006
21
Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. (16461912)
2006
22
Targeting stathmin in prostate cancer. (16373697)
2005
23
A novel knock-in prostate cancer model demonstrates biology similar to that of human prostate cancer and suitable for preclinical studies. (15727931)
2005
24
Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. (16005185)
2005
25
An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. (15266311)
2004
26
Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer. (15280008)
2004
27
Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events. (15390081)
2004
28
Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population]. (14574802)
2003
29
A comparative study of prostate specific antigen (PSA), C-terminal propeptide of blood type I procollagen (PICP) and urine type I collagen-crosslinked N telopeptide (NTx) levels using bone scintigraphy in prostate cancer patients. (12932112)
2003
30
Metastatic prostate cancer with normal level of serum prostate-specific antigen. (15072491)
2003
31
Evidence for activation of the renin-angiotensin system in the human prostate: increased angiotensin II and reduced AT(1) receptor expression in benign prostatic hyperplasia. (11793373)
2002
32
Differential activation of the IGF binding protein-3 promoter by butyrate in prostate cancer cells. (11956160)
2002
33
Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells. (12269771)
2002
34
Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. (11929948)
2002
35
Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. (11228105)
2001
36
Endothelin-1 production by prostate cancer cell lines is up-regulated by factors involved in cancer progression and down-regulated by androgens. (11746273)
2001
37
Contrasting effects of aspirin on prostate cancer cells: suppression of proliferation and induction of drug resistance . (10639187)
2000
38
Atypical case of metastatic undifferentiated prostate carcinoma in a 36 years old man: clinical report and literature review. (11141722)
2000
39
BRCA1 and BRCA2 have a limited role in familial prostate cancer. (10728701)
2000
40
Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. (10475365)
1999
41
Clinical pharmacokinetics of the antiandrogens and their efficacy in prostate cancer. (9592622)
1998
42
Immunocytochemical localization of an immunoconjugate (antibody IgG against prostatic acid phosphatase conjugated to 5-fluoro-2'-deoxyuridine) in human prostate tumors. (9673345)
1998
43
Selective expression of inducible nitric oxide synthase in human prostate carcinoma. (9587122)
1998
44
NGF-beta, NE-cells and prostatic cancer cell lines. A study of neuroendocrine expression in the human prostatic cancer cell lines DU-145, PC-3, LNCaP, and TSU-pr1 following stimulation of the nerve growth factor-beta. (9561567)
1998
45
Steroid-involved transcriptional regulation of human genes encoding prostatic acid phosphatase, prostate-specific antigen, and prostate-specific glandular kallikrein. (9275063)
1997
46
Free and total serum PSA values in patients with prostatic intraepithelial neoplasia (PIN), prostate cancer and BPH. Is F/T PSA a potential probe for dormant and manifest cancer? (9179191)
1997
47
Canine prostate disease. (8050933)
1994
48
Variability of values of prostate-specific antigen determined with 6 methods]. (7514278)
1994
49
Significance of high-grade prostatic intraepithelial neoplasia on needle biopsy. (7684999)
1993
50
Remarks on a New Mode of Affording Permanent Relief to Intractable Chronic Cystitis, and to Confirmed Prostatic Retention of Urine. (20750395)
1882

Variations for Prostatitis

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Expression for genes affiliated with Prostatitis

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Search GEO for disease gene expression data for Prostatitis.

Pathways for genes affiliated with Prostatitis

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Pathways related to Prostatitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Metalloproteases in connective tissue degradation
9.3KLK3, IL8

Compounds for genes affiliated with Prostatitis

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Compounds related to Prostatitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1provenge4310.1KLK3, ACPP
2estracyt4310.1ACPP, KLK3
3chlormadinone acetate4310.1KLK3, ACPP
4cpsa4310.1KLK3, PROS1
5nilutamide43 59 28 1212.8ACPP, KLK3
6estramustine phosphate439.8KLK3, PROS1, ACPP
7goserelin43 28 1211.8KLK3, ACPP, PROS1
8estramustine43 1210.8PROS1, KLK3, ACPP
9apotransferrin439.7CP, LTF
10ferric ammonium citrate439.7LTF, CP
11dtpa439.7ACPP, CP, KLK3
12diethylstilbestrol43 28 1211.6LTF, ACPP, KLK3
13tenidap43 2810.6LTF, ELANE
14dihydrotestosterone43 28 24 1212.5ACPP, PROS1, KLK3
15ciprofloxacin43 49 1211.5KLK3, LTF, CP
16nimesulide43 1210.4LTF, ELANE
17sivelestat sodium hydrate439.4IL8, ELANE
18curosurf439.4IL8, ELANE
19survanta439.4IL8, ELANE
20sivelestat439.4IL8, ELANE
21dextran sulfate439.4LTF, ELANE, KLK3
22tlck439.3ELANE, IL8
23alpha tocopherol439.3CP, ELANE, KLK3
24cilomilast439.3ELANE, IL8
25thyroxine43 2410.1KLK3, ELANE, CP
26gabexate mesilate439.0IL8, ELANE
27indomethacin43 28 59 1212.0GDF15, LTF, PROS1, CP
28creatinine438.9PROS1, CP, LTF, ACPP
29n-formylmethionyl-leucylphenylalanine438.9IL8, LTF, ELANE
30pentoxifylline43 129.9ELANE, IL8, LTF
31citrate438.9CP, ELANE, ACPP, LTF
32leukotriene b443 59 2410.8ELANE, IL8, LTF
33ulinastatin438.7IL8, ELANE
34vitamin d438.6ACPP, CP, PROS1, ELANE, KLK3
35testosterone43 59 24 1211.6ELANE, PROS1, CP, ACPP, KLK3
36aprotinin43 129.6ELANE, LTF, KLK3, IL8
37hydrocortisone43 2 59 1211.6LTF, ELANE, IL8, KLK3
38neopterin438.6IL8, ELANE, ACPP, LTF
39hyaluronic acid43 249.6LTF, KLK3, IL8, ELANE
40fmlp438.5ELANE, IL8, LTF
41protamine438.4LTF, CP, ELANE, IL8
42endotoxin438.4LTF, IL8, ELANE
43superoxide43 249.3LTF, IL8, ELANE, CP
44dexamethasone43 49 28 1211.3KLK3, IL8, PROS1, CP, LTF
45lactate438.2KLK3, CP, ELANE, ACPP, IL8
46h2o2438.2IL8, LTF, CP, ELANE
47estrogen438.1LTF, GDF15, CP, ACPP, ELANE, KLK3
48heparin43 28 24 1211.0ELANE, IL8, PROS1, LTF, CP
49vegf437.9IL8, CP, ACPP, KLK3, LTF, PROS1
50serine436.9ELANE, KLK3, LTF, ACPP, PROS1, CP

GO Terms for genes affiliated with Prostatitis

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Cellular components related to Prostatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301418.9ELANE, ACPP, LTF
2extracellular vesicular exosomeGO:00700628.4LTF, ACPP, ELANE, CP
3extracellular spaceGO:00056157.5GDF15, CP, ACPP, IL8, LTF
4extracellular regionGO:00055766.8LTF, KLK3, IL8, ELANE, PROS1, CP

Biological processes related to Prostatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular protein metabolic processGO:00442678.9KLK3, IL8, PROS1

Molecular functions related to Prostatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.0LTF, KLK3, ELANE

Products for genes affiliated with Prostatitis

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Sources for Prostatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet