MCID: PRS047
MIFTS: 62

Prostatitis malady

Summaries for Prostatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Prostatitis (less commonly prostatosis) is inflammation of the prostate gland. Prostatitis is classified... more...

MalaCards: Prostatitis is related to prostate cancer and adenocarcinoma. An important gene associated with Prostatitis is FOLH1 (folate hydrolase (prostate-specific membrane antigen) 1), and among its related pathways are Coregulation of Androgen receptor activity and Regulation of Androgen receptor activity. The drugs ciprofloxacin and norfloxacin and the compounds testosterone and dihydrotestosterone have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast.

Aliases & Classifications for Prostatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

prostatitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:14654
MeSH34 D011472
NCIt39 C26866
ICD9CM27 601.9, 601

Related Diseases for Prostatitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Prostatitis:



Diseases related to prostatitis

Clinical Features for Prostatitis

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Drugs & Therapeutics for Prostatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Prostatitis

Drug clinical trials:

Search ClinicalTrials for Prostatitis

Search NIH Clinical Center for Prostatitis

Search CenterWatch for Prostatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Prostatitis

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Anatomical Context for Prostatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Prostatitis:

32
Prostate, Bone, Breast, Endothelial, Testes, Lymph node, Lung, T cells, Bone marrow, Colon, Liver, Pituitary, Smooth muscle, Testis, Kidney, Skin, B cells, Brain, Monocytes, Heart, Ovary, Spinal cord, Myeloid, Thyroid, Placenta, Salivary gland, Pancreas, Cervix, Tongue, Adipocyte, Nk cells, Pineal, Appendix, Hypothalamus, Whole blood, Small intestine, Spleen, Uterus, Skeletal muscle

Animal Models for Prostatitis or affiliated genes

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Publications for Prostatitis

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50PubMed
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Articles related to Prostatitis:

(show top 50)    (show all 18416)
idTitleAuthorsYear
1
Beyond the limits of oxygen: effects of hypoxia in a hormone-independent prostate cancer cell line. (24167746)
2013
2
Validation of stem cell markers in clinical prostate cancer: I+6-Integrin is predictive for non-aggressive disease. (24375374)
2013
3
Long-term outcomes and toxicity in patients treated with brachytherapy for prostate adenocarcinoma younger than 60 years of age at treatment with minimum 10 years of follow-up. (23374803)
2013
4
Genetic variants in CASP3, BMP5, and IRS2 genes may influence survival in prostate cancer patients receiving androgen-deprivation therapy. (22844442)
2012
5
Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment. (20883485)
2011
6
Treatment efficiency, outcome and surgical treatment problems in patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma: a report from the Cooperative Soft Tissue Sarcoma trial CWS-96. (21370402)
2011
7
Overexpression of aldo-keto reductase 1C2 is associated with disease progression in patients with prostatic cancer. (20840669)
2010
8
Efficacy and safety of combined treatment of prostatic adenoma with 5-alpha reductase and alpha-adrenoblockers]. (20169718)
2009
9
Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. (19013255)
2009
10
Will GnRH antagonists improve prostate cancer treatment? (19008119)
2009
11
miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells. (19544444)
2009
12
The evolving role of oestrogens and their receptors in the development and progression of prostate cancer. (19013008)
2009
13
Cigarette smoking and prostate cancer in a prospective US cohort study. (19706848)
2009
14
Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer. (18460741)
2008
15
Degarelix: a novel gonadotropin-releasing hormone (GnRH) receptor blocker--results from a 1-yr, multicentre, randomised, phase 2 dosage-finding study in the treatment of prostate cancer. (18538469)
2008
16
Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression. (19010864)
2008
17
C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: results from the ASCENT trial. (18428198)
2008
18
Bony lesion with prostate cancer]. (18379023)
2008
19
The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90. (18726985)
2008
20
Peroxisome Proliferator-Activated Receptor-gamma Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer. (18317513)
2008
21
Adult prostate sarcoma: a report of 6 cases with clinical analysis]. (17725305)
2007
22
Genetic background influences murine prostate gene expression: implications for cancer phenotypes. (17577413)
2007
23
Prognostic relevance of increased Rac GTPase expression in prostate carcinomas. (17639041)
2007
24
APC I1307K and the risk of prostate cancer. (16537703)
2006
25
First- and second-line chemotherapy with docetaxel or mitoxantrone in patients with hormone-refractory prostate cancer: does sequence matter? (16456811)
2006
26
Alteration of gene expression in response to bone morphogenetic protein-2 in androgen-dependent human prostate cancer LNCaP cells. (16391828)
2006
27
Amplification of the urokinase gene and the sensitivity of prostate cancer cells to urokinase inhibitors. (16430655)
2006
28
Enzymatic prostatic acid phosphatase in the clinical staging of patients diagnosed with prostate cancer. (16161529)
2005
29
Interleukin-6 is responsible for drug resistance and anti-apoptotic effects in prostatic cancer cells. (15162378)
2004
30
Arsenite induces p70S6K1 activation and HIF-1alpha expression in prostate cancer cells. (14971642)
2004
31
Dexamethasone enhances the cytotoxic effect of radioiodine therapy in prostate cancer cells expressing the sodium iodide symporter. (15001595)
2004
32
In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. (14734476)
2004
33
Early versus delayed hormonal therapy for prostate specific antigen only recurrence of prostate cancer after radical prostatectomy. (14767288)
2004
34
The role of thymidine phosphorylase (TP) mRNA expression in angiogenesis of prostate cancer. (12820387)
2003
35
Can complexed prostate specific antigen and prostatic volume enhance prostate cancer detection in men with total prostate specific antigen between 2.5 and 4.0 ng./ml. (11371884)
2001
36
Interleukin-6 and prostate cancer progression. (11312117)
2001
37
Human prostate cancer and benign prostatic hyperplasia: molecular dissection by gene expression profiling. (11406537)
2001
38
Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China. (11016637)
2000
39
Prostate specific antigen density for discriminating prostate cancer from benign prostatic hyperplasia in the gray zone of prostate-specific antigen. (10466060)
1999
40
Review of phase II hormone refractory prostate cancer trials. (10606280)
1999
41
Alpha1-adrenoceptors in testosterone-induced prostatic hypertrophy. (9489864)
1998
42
P-cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer. (9815605)
1997
43
Mutation of the tumor suppressor gene p53 in human prostate and bladder cancers--investigation by temperature gradient gel electrophoresis (TGGE). (9072541)
1997
44
Androgens regulate the expression of proliferating cell nuclear antigen posttranscriptionally in the human prostate cancer cell line, LNCaP. (8603399)
1996
45
Microwave hyperthermia in benign prostatic hypertrophy: a controlled clinical trial. (7544207)
1995
46
Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines. (9816072)
1995
47
Growth modulation of human prostatic cancer cells by interleukin-1 and interleukin-1 receptor antagonist. (7656219)
1995
48
Ectopic production of prostate specific antigen by a breast tumor metastatic to the ovary. (7523638)
1994
49
Serum gamma-seminoprotein determination in prostatic cancer. (1716404)
1991
50
Distribution of specific binding of [3H]promegestone in benign prostatic hypertrophy in regard to age, race and histological differences. (6200694)
1983

Genetic Variations for Prostatitis

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Expression for genes affiliated with Prostatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostatitis

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Pathways for genes affiliated with Prostatitis

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Prostatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3PAWR, KLK3, KLK2
211.3SPDEF, KLK3, KLK2
311.0KLK3, KLK2

Compounds for genes affiliated with Prostatitis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Prostatitis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.3KLK2, KLK3, FOLH1, ACPP, MSMB, SPDEF
2dihydrotestosterone44 28 11 2415.1SPDEF, ACPP, FOLH1, KLK3, KLK2
3prostascint4411.3KLK3, FOLH1
4provenge4411.3ACPP, KLK3
5heme28 11 2413.3STEAP4, STEAP2, STEAP1
6estracyt4411.3ACPP, KLK3
7chlormadinone acetate4411.2ACPP, KLK3
8estramustine phosphate4411.2KLK3, ACPP
9goserelin44 28 1113.2ACPP, KLK3
10nilutamide44 59 28 1114.2ACPP, KLK3
11buserelin44 28 1113.1KLK3, ACPP
12estramustine44 1112.1KLK3, ACPP
13finasteride44 59 11 2414.0KLK3, ACPP
14dtpa4410.9ACPP, KLK3
15cyproteroneacetate4410.7ACPP, KLK3

GO Terms for genes affiliated with Prostatitis

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16Gene Ontology
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Cellular components related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:01000811.3PARM1, STEAP2, STEAP1

Biological processes related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681111.3STEAP4, STEAP2, STEAP1
2iron ion homeostasisGO:05507211.0STEAP4, STEAP2, STEAP1

Molecular functions related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transporter activityGO:00521511.3SYT7, STEAP2, STEAP1
2oxidoreductase activityGO:01649111.0STEAP4, STEAP2, STEAP1

Products for genes affiliated with Prostatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet