MCID: PRS047
MIFTS: 60

Prostatitis malady

Reproductive diseases category

Summaries for Prostatitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Prostatitis (less commonly prostatosis) is inflammation of the prostate gland. Prostatitis is classified... more...

MalaCards: Prostatitis is related to prostate cancer and adenocarcinoma. An important gene associated with Prostatitis is KLK3 (kallikrein-related peptidase 3), and among its related pathways are Selected targets of C EBPalpha and Cell adhesion ECM remodeling. The drugs ciprofloxacin and norfloxacin and the compounds provenge and estracyt have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Prostatitis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

prostatitis 9 11 46 63


External Ids:

Disease Ontology9 DOID:14654
ICD9CM28 601, 601.9
NCIt41 C26866
MeSH36 D011472

Related Diseases for Prostatitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Prostatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 645)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer32.6GDF15, ACPP, KLK3, PROS1
2adenocarcinoma31.9ACPP, PROS1, GDF15, KLK3
3prostatic hypertrophy31.8ACPP, KLK3
4prostate disease31.5KLK3, ACPP
5prostatic adenoma31.1ACPP, KLK3
6breast cancer31.1GDF15, CP, ACPP, KLK3
7adenoma31.1GDF15, ACPP, CP
8proctitis30.7LTF, KLK3
9colorectal cancer30.5GDF15, PROS1, LTF, CP
10pancreatitis30.5LTF, ELANE
11melanoma30.3IL8, CP, GDF15, LTF
12clear cell adenocarcinoma30.2ACPP, KLK3
13liver cirrhosis30.0CP, ACPP, LTF
14vasculitis29.8PROS1, ELANE, LTF
15periodontitis29.7LTF, IL8, ELANE
16polyarteritis nodosa29.7LTF
17periodontal disease29.7IL8, LTF, ELANE
18sepsis29.7ELANE, LTF, IL8
19atherosclerosis29.7CP, ELANE, IL8
20cystic fibrosis29.7IL8, LTF, ELANE, CP
21gingivitis29.6ELANE, LTF
22neutropenia29.6KLK3, ELANE, CP
23monocytic leukemia29.6LTF, IL8
24arthritis29.5LTF, IL8, ACPP
25septic shock29.5ELANE, IL8, LTF
26ulcerative colitis29.5IL8, LTF, ELANE
27rheumatoid arthritis29.4ELANE, IL8, LTF, CP
28prostate adenocarcinoma11.2
29endotheliitis10.9
30paine syndrome10.9
31urethritis10.7
32familial prostate cancer10.7
33hypoxia10.7
34small cell carcinoma10.6
35rhabdomyosarcoma10.6
36blindness10.5
37leukemia10.5
38mucinous adenocarcinoma10.5
39obesity10.5
40hypogonadism10.5
41prostatic cyst10.5
42urethral stricture10.5
43malakoplakia10.5
44transitional cell carcinoma10.4
45retinoblastoma10.4
46sarcoma10.4
47neuroendocrine carcinoma10.4
48prostate rhabdomyosarcoma10.4
49embryonal rhabdomyosarcoma10.4
50ovarian cancer10.4

Graphical network of the top 20 diseases related to Prostatitis:



Diseases related to prostatitis

Symptoms for Prostatitis

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Drugs & Therapeutics for Prostatitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Prostatitis

Drug clinical trials:

Search ClinicalTrials for Prostatitis

Search NIH Clinical Center for Prostatitis

Search CenterWatch for Prostatitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Prostatitis

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Anatomical Context for Prostatitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Prostatitis:

34
Prostate, Bone, Breast, Endothelial, Testes, Lymph node, Lung, T cells, Bone marrow, Colon, Liver, Pituitary, Smooth muscle, Testis, Kidney, Skin, B cells, Brain, Monocytes, Heart, Spinal cord, Ovary, Myeloid, Thyroid, Placenta, Salivary gland, Pancreas, Cervix, Tongue, Adipocyte, Nk cells, Pineal, Appendix, Hypothalamus, Whole blood, Small intestine, Spleen, Uterus, Skeletal muscle

Animal Models for Prostatitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Prostatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6LTF, PROS1, CP, GDF15
2MP:00053976.8LTF, GDF15, CP, PROS1, ELANE, IL8

Publications for Prostatitis

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Sources:
53PubMed
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Articles related to Prostatitis:

(show top 50)    (show all 18210)
idTitleAuthorsYear
1
Lumican expression, localization and antitumor activity in prostate cancer. (23399832)
2013
2
Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. (23676682)
2013
3
Pre-prostatic tissue removed in robotic assisted lymph node dissection for prostate cancer contains lymph nodes. (24311906)
2013
4
No evidence of FGFR3 mutations in prostate cancer. (20957671)
2011
5
Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. (19820934)
2010
6
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF- kappaB activity in prostate cancer cells. (20068069)
2010
7
CYP17 polymorphisms and prostate cancer outcomes. (20503394)
2010
8
Promising tumor-associated antigens for future prostate cancer therapy. (19536865)
2010
9
Other biomarkers for detecting prostate cancer. (19930175)
2010
10
Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. (18824345)
2009
11
Y chromosome haplotypes and prostate cancer in Sweden. (18927315)
2008
12
A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. (18703514)
2008
13
Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk: a replication study in an ethnically homogeneous population. (18537123)
2008
14
A common 8q24 variant in prostate and breast cancer from a large nested case-control study. (17409400)
2007
15
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. (17443494)
2007
16
P2Y purinergic receptor activated PI-3K/Akt signaling pathway in regulation of growth and invasion of prostatic cancer]. (18194602)
2007
17
Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer. (16698360)
2006
18
Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer. (16388505)
2006
19
The hidden condition: status, challenges, and opportunities in the management of enlarged prostate for managed care. (16551205)
2006
20
Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells. (17079215)
2006
21
Characterization of frequently deleted 6q locus in prostate cancer. (17132090)
2006
22
Targeting stathmin in prostate cancer. (16373697)
2005
23
A novel knock-in prostate cancer model demonstrates biology similar to that of human prostate cancer and suitable for preclinical studies. (15727931)
2005
24
An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. (15266311)
2004
25
Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer. (15280008)
2004
26
Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events. (15390081)
2004
27
Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population]. (14574802)
2003
28
A comparative study of prostate specific antigen (PSA), C-terminal propeptide of blood type I procollagen (PICP) and urine type I collagen-crosslinked N telopeptide (NTx) levels using bone scintigraphy in prostate cancer patients. (12932112)
2003
29
Metastatic prostate cancer with normal level of serum prostate-specific antigen. (15072491)
2003
30
Evidence for activation of the renin-angiotensin system in the human prostate: increased angiotensin II and reduced AT(1) receptor expression in benign prostatic hyperplasia. (11793373)
2002
31
A phase II Hoosier Oncology Group study of vinorelbine and estramustine phosphate in hormone-refractory prostate cancer. (11996476)
2002
32
Differential activation of the IGF binding protein-3 promoter by butyrate in prostate cancer cells. (11956160)
2002
33
Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells. (12269771)
2002
34
Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. (11929948)
2002
35
Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. (11228105)
2001
36
Contrasting effects of aspirin on prostate cancer cells: suppression of proliferation and induction of drug resistance . (10639187)
2000
37
Atypical case of metastatic undifferentiated prostate carcinoma in a 36 years old man: clinical report and literature review. (11141722)
2000
38
BRCA1 and BRCA2 have a limited role in familial prostate cancer. (10728701)
2000
39
Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. (10475365)
1999
40
Clinical pharmacokinetics of the antiandrogens and their efficacy in prostate cancer. (9592622)
1998
41
Immunocytochemical localization of an immunoconjugate (antibody IgG against prostatic acid phosphatase conjugated to 5-fluoro-2'-deoxyuridine) in human prostate tumors. (9673345)
1998
42
Selective expression of inducible nitric oxide synthase in human prostate carcinoma. (9587122)
1998
43
NGF-beta, NE-cells and prostatic cancer cell lines. A study of neuroendocrine expression in the human prostatic cancer cell lines DU-145, PC-3, LNCaP, and TSU-pr1 following stimulation of the nerve growth factor-beta. (9561567)
1998
44
Steroid-involved transcriptional regulation of human genes encoding prostatic acid phosphatase, prostate-specific antigen, and prostate-specific glandular kallikrein. (9275063)
1997
45
Free and total serum PSA values in patients with prostatic intraepithelial neoplasia (PIN), prostate cancer and BPH. Is F/T PSA a potential probe for dormant and manifest cancer? (9179191)
1997
46
Sorting of heparan sulfate proteoglycan into matrix compartments of prostate adenocarcinoma cells. (7830405)
1995
47
Canine prostate disease. (8050933)
1994
48
Variability of values of prostate-specific antigen determined with 6 methods]. (7514278)
1994
49
Significance of high-grade prostatic intraepithelial neoplasia on needle biopsy. (7684999)
1993
50
Remarks on a New Mode of Affording Permanent Relief to Intractable Chronic Cystitis, and to Confirmed Prostatic Retention of Urine. (20750395)
1882

Variations for Prostatitis

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Expression for genes affiliated with Prostatitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostatitis

Search GEO for disease gene expression data for Prostatitis.

Pathways for genes affiliated with Prostatitis

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Sources:
51PathCards, 13EMD Millipore, 61Thomson Reuters
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Pathways related to Prostatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3LTF, ELANE
2
Show member pathways
9.3KLK3, IL8

Compounds for genes affiliated with Prostatitis

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Prostatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1provenge4610.1KLK3, ACPP
2estracyt4610.1ACPP, KLK3
3chlormadinone acetate4610.1KLK3, ACPP
4cpsa4610.1KLK3, PROS1
5nilutamide46 62 30 1212.8ACPP, KLK3
6estramustine phosphate469.8KLK3, PROS1, ACPP
7goserelin46 30 1211.8KLK3, ACPP, PROS1
8estramustine46 1210.8PROS1, KLK3, ACPP
9apotransferrin469.7CP, LTF
10ferric ammonium citrate469.7LTF, CP
11dtpa469.7ACPP, CP, KLK3
12diethylstilbestrol46 30 1211.6LTF, ACPP, KLK3
13tenidap46 3010.6LTF, ELANE
14dihydrotestosterone46 30 25 1212.5ACPP, PROS1, KLK3
15ciprofloxacin46 52 1211.5KLK3, LTF, CP
16nimesulide46 1210.4LTF, ELANE
17sivelestat sodium hydrate469.4IL8, ELANE
18curosurf469.4IL8, ELANE
19survanta469.4IL8, ELANE
20sivelestat469.4IL8, ELANE
21dextran sulfate469.4LTF, ELANE, KLK3
22tlck469.3ELANE, IL8
23alpha tocopherol469.3CP, ELANE, KLK3
24cilomilast469.3ELANE, IL8
25thyroxine46 2510.1KLK3, ELANE, CP
26gabexate mesilate469.0IL8, ELANE
27indomethacin46 30 62 1212.0GDF15, LTF, PROS1, CP
28creatinine468.9PROS1, CP, LTF, ACPP
29n-formylmethionyl-leucylphenylalanine468.9IL8, LTF, ELANE
30pentoxifylline46 129.9ELANE, IL8, LTF
31citrate468.9CP, ELANE, ACPP, LTF
32leukotriene b446 62 2510.8ELANE, IL8, LTF
33ulinastatin468.7IL8, ELANE
34vitamin d468.6ACPP, CP, PROS1, ELANE, KLK3
35testosterone46 62 25 1211.6ELANE, PROS1, CP, ACPP, KLK3
36aprotinin46 129.6ELANE, LTF, KLK3, IL8
37hydrocortisone46 3 62 1211.6LTF, ELANE, IL8, KLK3
38neopterin468.6IL8, ELANE, ACPP, LTF
39hyaluronic acid46 259.6LTF, KLK3, IL8, ELANE
40fmlp468.5ELANE, IL8, LTF
41protamine468.4LTF, CP, ELANE, IL8
42endotoxin468.4LTF, IL8, ELANE
43superoxide46 259.3LTF, IL8, ELANE, CP
44dexamethasone46 52 30 1211.3KLK3, IL8, PROS1, CP, LTF
45lactate468.2KLK3, CP, ELANE, ACPP, IL8
46h2o2468.2IL8, LTF, CP, ELANE
47estrogen468.1LTF, GDF15, CP, ACPP, ELANE, KLK3
48heparin46 30 25 1211.0ELANE, IL8, PROS1, LTF, CP
49vegf467.9IL8, CP, ACPP, KLK3, LTF, PROS1
50serine466.9ELANE, KLK3, LTF, ACPP, PROS1, CP

GO Terms for genes affiliated with Prostatitis

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Sources:
17Gene Ontology
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Cellular components related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.9ELANE, ACPP, LTF
2extracellular vesicular exosomeGO:0700628.4LTF, ACPP, ELANE, CP
3extracellular spaceGO:0056157.5GDF15, CP, ACPP, IL8, LTF
4extracellular regionGO:0055766.8LTF, GDF15, CP, PROS1, ELANE, IL8

Biological processes related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular protein metabolic processGO:0442678.9KLK3, IL8, PROS1

Molecular functions related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.0LTF, KLK3, ELANE

Products for genes affiliated with Prostatitis

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  • Antibodies
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Sources for Prostatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet