MCID: PRS047
MIFTS: 62

Prostatitis malady

Summaries for Prostatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Prostatitis (less commonly prostatosis) is inflammation of the prostate gland. Prostatitis is classified... more...

MalaCards: Prostatitis is related to prostate cancer and adenocarcinoma. An important gene associated with Prostatitis is FOLH1 (folate hydrolase (prostate-specific membrane antigen) 1), and among its related pathways are Coregulation of Androgen receptor activity and Regulation of Androgen receptor activity. The drugs ciprofloxacin and norfloxacin and the compounds testosterone and dihydrotestosterone have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast.

Aliases & Classifications for Prostatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

prostatitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:14654
MeSH34 D011472
NCIt39 C26866
ICD9CM27 601.9, 601

Related Diseases for Prostatitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Prostatitis:



Diseases related to prostatitis

Clinical Features for Prostatitis

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Drugs & Therapeutics for Prostatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Prostatitis

Drug clinical trials:

Search ClinicalTrials for Prostatitis

Search NIH Clinical Center for Prostatitis

Search CenterWatch for Prostatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Prostatitis

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Anatomical Context for Prostatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Prostatitis:

32
Prostate, Bone, Breast, Endothelial, Testes, Lymph node, Lung, T cells, Bone marrow, Colon, Liver, Pituitary, Smooth muscle, Testis, Kidney, Skin, B cells, Brain, Monocytes, Heart, Ovary, Spinal cord, Myeloid, Thyroid, Placenta, Salivary gland, Pancreas, Cervix, Tongue, Adipocyte, Nk cells, Pineal, Appendix, Hypothalamus, Whole blood, Small intestine, Spleen, Uterus, Skeletal muscle

Animal Models for Prostatitis or affiliated genes

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Publications for Prostatitis

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50PubMed
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Articles related to Prostatitis:

(show top 50)    (show all 18416)
idTitleAuthorsYear
1
Targeted androgen pathway suppression in localized prostate cancer: a pilot study. (24323034)
2014
2
FROGG high-risk prostate cancer workshop: Patterns of practice and literature review. Part II post-radical prostatectomy. (24345209)
2013
3
IgG4-Related Autoimmune Prostatitis: Is It an Unusual or Underdiagnosed Manifestation of IgG4-Related Disease? (24349818)
2013
4
Transabdominal ultrasound measurement of pelvic floor muscle mobility in men with and without chronic prostatitis/chronic pelvic pain syndrome. (22925244)
2012
5
Prostate extract with aluminum hydroxide injection as a novel animal model for chronic prostatitis/chronic pelvic pain syndrome. (23017785)
2012
6
The inhibitory effects of NKX3.1 on IGF-1R expression and its signalling pathway in human prostatic carcinoma PC3 cells. (22179513)
2012
7
Use of the UPOINT chronic prostatitis/chronic pelvic pain syndrome classification in European patient cohorts: sexual function domain improves correlations. (20952019)
2010
8
Isoforms of hyaluronidases can be a predictor of a prostate cancer of good prognosis. (18639473)
2009
9
Longitudinal cytokine expression during IMRT for prostate cancer and acute treatment toxicity. (19706801)
2009
10
Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor. (19883429)
2009
11
Growth inhibitory effect of KrA1ppel-like factor 6 on human prostatic carcinoma and renal carcinoma cell lines. (18719336)
2008
12
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. (18663430)
2008
13
Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. (18386288)
2008
14
Chronic prostatitis/chronic pelvic pain syndrome and male interstitial cystitis: enigmas and opportunities. (17462482)
2007
15
Neuroendocrine differentiation in prostate adenocarcinoma. (17985422)
2007
16
Increased levels of IgG antibodies against peptides of the prostate stem cell antigen in the plasma of pancreatic cancer patients. (17549363)
2007
17
Thyroid transcription factor-1 may be expressed in ductal adenocarcinoma of the prostate:a potential pitfall. (17660340)
2007
18
Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer. (17096324)
2007
19
Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro. (16669706)
2006
20
Six-month androgen suppression plus radiation therapy compared with radiation therapy alone for men with prostate cancer and a rapidly increasing pretreatment prostate-specific antigen level. (16943536)
2006
21
A role for the WWOX gene in prostate cancer. (16818616)
2006
22
Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1. (16407310)
2006
23
Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene. (16401639)
2006
24
Prostate-specific membrane antigen expression predicts prostate cancer recurrence. (16841802)
2006
25
The chromogranin-A (CgA) in prostate cancer. (16280180)
2006
26
Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells. (16880611)
2006
27
Androgen suppression plus radiation versus radiation alone for patients with stage D1/pathologic node-positive adenocarcinoma of the prostate: updated results based on national prospective randomized trial Radiation Therapy Oncology Group 85-31. (15681524)
2005
28
A role for surfactant protein D in innate immunity of the human prostate. (15948134)
2005
29
Synergistic antiproliferative and apoptotic effects induced by mixed epidermal growth factor receptor inhibitor ZD1839 and nitric oxide donor in human prostatic cancer cell lines. (15389789)
2005
30
Immunohistochemical expression of Ki-67 antigen, cox-2 and Bax/Bcl-2 in prostate cancer; prognostic value in biopsies and radical prostatectomy specimens. (16139948)
2005
31
Expression and its significance of b-FGF in human benign prostatic hyperplasia and prostatic carcinoma tissues]. (15191726)
2004
32
p53 gene codon 72 polymorphism but not tumor necrosis factor-alpha gene is associated with prostate cancer. (15263792)
2004
33
PC-3 cells with enhanced androgen receptor signaling: a model for clonal selection in prostate cancer. (15264248)
2004
34
FGF8 isoform b expression in human prostate cancer. (12778074)
2003
35
Polymorphisms in glutathione-S-transferase genes (GST-M1, GST-T1 and GST-P1) and susceptibility to prostate cancer among male smokers of the ATBC cancer prevention study. (12883385)
2003
36
Radiosensitivity with Par-4 expression in prostate cancer. (12212614)
2002
37
Molecular markers in prostate cancer: the role in preoperative staging. (15046712)
2002
38
A novel anti-proliferative property of clusterin in prostate cancer cells. (12409141)
2002
39
Mitoxantrone in patients with prostate specific antigen progression after local therapy for prostate carcinoma. (11596021)
2001
40
Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures. (11506501)
2001
41
Loss of heterozygosity at 12P12-13 in primary and metastatic prostate adenocarcinoma. (10840458)
2000
42
Expression of pepsinogen II with androgen and estrogen receptors in human prostate carcinoma. (10338074)
1999
43
Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer. (10373563)
1999
44
Assessment of prostate cancer volume using endorectal coil magnetic resonance imaging: a new predictor of tumor response to neoadjuvant androgen suppression therapy. (9495713)
1998
45
Importance of vitamin D in prostatic carcinoma]. (8998822)
1996
46
Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. (7639332)
1995
47
Detection of prostate-specific antigen immunoreactivity in breast tumors. (7532468)
1994
48
Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. (7987830)
1994
49
Utilization of bone scans in conjunction with prostate-specific antigen levels in the surveillance for recurrence of adenocarcinoma after radical prostatectomy. (1715394)
1991
50
Diverse secretory patterns of clusterin by epididymis and prostate/seminal vesicles undergoing cell regression after orchiectomy. (2351105)
1990

Genetic Variations for Prostatitis

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Expression for genes affiliated with Prostatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostatitis

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Pathways for genes affiliated with Prostatitis

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Prostatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3PAWR, KLK3, KLK2
211.3SPDEF, KLK3, KLK2
311.0KLK3, KLK2

Compounds for genes affiliated with Prostatitis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Prostatitis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.3KLK2, KLK3, FOLH1, ACPP, MSMB, SPDEF
2dihydrotestosterone44 28 11 2415.1SPDEF, ACPP, FOLH1, KLK3, KLK2
3prostascint4411.3KLK3, FOLH1
4provenge4411.3ACPP, KLK3
5heme28 11 2413.3STEAP4, STEAP2, STEAP1
6estracyt4411.3ACPP, KLK3
7chlormadinone acetate4411.2ACPP, KLK3
8estramustine phosphate4411.2KLK3, ACPP
9goserelin44 28 1113.2ACPP, KLK3
10nilutamide44 59 28 1114.2ACPP, KLK3
11buserelin44 28 1113.1KLK3, ACPP
12estramustine44 1112.1KLK3, ACPP
13finasteride44 59 11 2414.0KLK3, ACPP
14dtpa4410.9ACPP, KLK3
15cyproteroneacetate4410.7ACPP, KLK3

GO Terms for genes affiliated with Prostatitis

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16Gene Ontology
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Cellular components related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:01000811.3PARM1, STEAP2, STEAP1

Biological processes related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681111.3STEAP4, STEAP2, STEAP1
2iron ion homeostasisGO:05507211.0STEAP4, STEAP2, STEAP1

Molecular functions related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transporter activityGO:00521511.3SYT7, STEAP2, STEAP1
2oxidoreductase activityGO:01649111.0STEAP4, STEAP2, STEAP1

Products for genes affiliated with Prostatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet