MCID: PRS047
MIFTS: 60

Prostatitis malady

Reproductive diseases category
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Summaries for Prostatitis

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Wikipedia:65 Prostatitis (less commonly prostatosis) is inflammation of the prostate gland. Prostatitis is classified... more...

MalaCards based summary: Prostatitis is related to prostate cancer and prostatic hypertrophy. An important gene associated with Prostatitis is KLK3 (kallikrein-related peptidase 3), and among its related pathways are Selected targets of C EBPalpha and Cell adhesion ECM remodeling. The drugs ciprofloxacin and norfloxacin and the compounds provenge and estracyt have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Prostatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
See all sources

Prostatitis, Aliases & Descriptions:

Name: Prostatitis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:14654
ICD9CM27 601, 601.9
MeSH34 D011472
NCIt39 C26866

Related Diseases for Prostatitis

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Diseases related to Prostatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 667)
idRelated DiseaseScoreTop Affiliating Genes
1prostate cancer32.6GDF15, ACPP, KLK3, PROS1
2prostatic hypertrophy32.2ACPP, KLK3
3prostate disease31.9KLK3, ACPP
4adenocarcinoma31.8ACPP, PROS1, GDF15, KLK3
5prostatic adenoma31.5ACPP, KLK3
6proctitis31.1LTF, KLK3
7adenoma31.0GDF15, ACPP, CP
8breast cancer30.8GDF15, CP, ACPP, KLK3
9pancreatitis30.5LTF, ELANE
10colorectal cancer30.3GDF15, PROS1, LTF, CP
11polyarteritis nodosa30.3LTF
12epithelial-myoepithelial carcinoma30.1ACPP, KLK3
13liver cirrhosis30.0CP, ACPP, LTF
14melanoma29.9IL8, CP, GDF15, LTF
15vasculitis29.8PROS1, ELANE, LTF
16gingivitis29.8ELANE, LTF
17neutropenia29.6KLK3, ELANE, CP
18monocytic leukemia29.6LTF, IL8
19periodontitis29.6LTF, IL8, ELANE
20periodontal disease29.5IL8, LTF, ELANE
21sepsis29.5ELANE, LTF, IL8
22colitis29.4IL8, LTF
23arthritis29.4LTF, IL8, ACPP
24septic shock29.3ELANE, IL8, LTF
25atherosclerosis29.3CP, ELANE, IL8
26ulcerative colitis29.3IL8, LTF, ELANE
27cystic fibrosis29.2IL8, LTF, ELANE, CP
28rheumatoid arthritis29.0ELANE, IL8, LTF, CP
29prostate adenocarcinoma11.2
30endotheliitis10.9
31urethritis10.8
32hypoxia10.7
33small cell carcinoma10.6
34rhabdomyosarcoma10.6
35blindness10.6
36leukemia10.5
37mucinous adenocarcinoma10.5
38obesity10.5
39hypogonadism10.5
40urethral stricture10.5
41malakoplakia10.5
42prostatic cyst10.5
43sarcoma10.5
44transitional cell carcinoma10.5
45neuroendocrine carcinoma10.5
46prostate rhabdomyosarcoma10.5
47retinoblastoma10.5
48embryonal rhabdomyosarcoma10.4
49ovarian cancer10.4
50urethral obstruction10.4

Graphical network of the top 20 diseases related to Prostatitis:



Diseases related to prostatitis

Symptoms for Prostatitis

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Drugs & Therapeutics for Prostatitis

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Drug clinical trials:

Search ClinicalTrials for Prostatitis

Search NIH Clinical Center for Prostatitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Prostatitis

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Anatomical Context for Prostatitis

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MalaCards organs/tissues related to Prostatitis:

32
Prostate, Bone, Breast, Endothelial, Testes, Lymph node, Lung, T cells, Bone marrow, Colon, Liver, Pituitary, Smooth muscle, Testis, Kidney, Skin, B cells, Brain, Spinal cord, Heart, Ovary, Monocytes, Myeloid, Placenta, Thyroid, Pancreas, Salivary gland, Nk cells, Neutrophil, Cervix, Adipocyte, Tongue, Eye, Whole blood, Spleen, Skeletal muscle, Small intestine, Uterus, Hypothalamus, Appendix, Pineal

Animal Models for Prostatitis or affiliated genes

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MGI Mouse Phenotypes related to Prostatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6LTF, PROS1, CP, GDF15
2MP:00053976.8LTF, GDF15, CP, PROS1, ELANE, IL8

Publications for Prostatitis

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Articles related to Prostatitis:

(show top 50)    (show all 18666)
idTitleAuthorsYear
1
Lumican expression, localization and antitumor activity in prostate cancer. (23399832)
2013
2
Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. (23676682)
2013
3
Pre-prostatic tissue removed in robotic assisted lymph node dissection for prostate cancer contains lymph nodes. (24311906)
2013
4
No evidence of FGFR3 mutations in prostate cancer. (20957671)
2011
5
Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. (19820934)
2010
6
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF- kappaB activity in prostate cancer cells. (20068069)
2010
7
CYP17 polymorphisms and prostate cancer outcomes. (20503394)
2010
8
Promising tumor-associated antigens for future prostate cancer therapy. (19536865)
2010
9
Other biomarkers for detecting prostate cancer. (19930175)
2010
10
Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. (18824345)
2009
11
Y chromosome haplotypes and prostate cancer in Sweden. (18927315)
2008
12
A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. (18703514)
2008
13
Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk: a replication study in an ethnically homogeneous population. (18537123)
2008
14
A common 8q24 variant in prostate and breast cancer from a large nested case-control study. (17409400)
2007
15
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. (17443494)
2007
16
P2Y purinergic receptor activated PI-3K/Akt signaling pathway in regulation of growth and invasion of prostatic cancer]. (18194602)
2007
17
Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer. (16698360)
2006
18
Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer. (16388505)
2006
19
The hidden condition: status, challenges, and opportunities in the management of enlarged prostate for managed care. (16551205)
2006
20
Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells. (17079215)
2006
21
Characterization of frequently deleted 6q locus in prostate cancer. (17132090)
2006
22
Targeting stathmin in prostate cancer. (16373697)
2005
23
A novel knock-in prostate cancer model demonstrates biology similar to that of human prostate cancer and suitable for preclinical studies. (15727931)
2005
24
An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. (15266311)
2004
25
Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer. (15280008)
2004
26
Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events. (15390081)
2004
27
Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population]. (14574802)
2003
28
A comparative study of prostate specific antigen (PSA), C-terminal propeptide of blood type I procollagen (PICP) and urine type I collagen-crosslinked N telopeptide (NTx) levels using bone scintigraphy in prostate cancer patients. (12932112)
2003
29
Metastatic prostate cancer with normal level of serum prostate-specific antigen. (15072491)
2003
30
Evidence for activation of the renin-angiotensin system in the human prostate: increased angiotensin II and reduced AT(1) receptor expression in benign prostatic hyperplasia. (11793373)
2002
31
A phase II Hoosier Oncology Group study of vinorelbine and estramustine phosphate in hormone-refractory prostate cancer. (11996476)
2002
32
Differential activation of the IGF binding protein-3 promoter by butyrate in prostate cancer cells. (11956160)
2002
33
Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells. (12269771)
2002
34
Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. (11929948)
2002
35
Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. (11228105)
2001
36
Contrasting effects of aspirin on prostate cancer cells: suppression of proliferation and induction of drug resistance . (10639187)
2000
37
Atypical case of metastatic undifferentiated prostate carcinoma in a 36 years old man: clinical report and literature review. (11141722)
2000
38
BRCA1 and BRCA2 have a limited role in familial prostate cancer. (10728701)
2000
39
Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. (10475365)
1999
40
Clinical pharmacokinetics of the antiandrogens and their efficacy in prostate cancer. (9592622)
1998
41
Immunocytochemical localization of an immunoconjugate (antibody IgG against prostatic acid phosphatase conjugated to 5-fluoro-2'-deoxyuridine) in human prostate tumors. (9673345)
1998
42
Selective expression of inducible nitric oxide synthase in human prostate carcinoma. (9587122)
1998
43
NGF-beta, NE-cells and prostatic cancer cell lines. A study of neuroendocrine expression in the human prostatic cancer cell lines DU-145, PC-3, LNCaP, and TSU-pr1 following stimulation of the nerve growth factor-beta. (9561567)
1998
44
Steroid-involved transcriptional regulation of human genes encoding prostatic acid phosphatase, prostate-specific antigen, and prostate-specific glandular kallikrein. (9275063)
1997
45
Free and total serum PSA values in patients with prostatic intraepithelial neoplasia (PIN), prostate cancer and BPH. Is F/T PSA a potential probe for dormant and manifest cancer? (9179191)
1997
46
Sorting of heparan sulfate proteoglycan into matrix compartments of prostate adenocarcinoma cells. (7830405)
1995
47
Canine prostate disease. (8050933)
1994
48
Variability of values of prostate-specific antigen determined with 6 methods]. (7514278)
1994
49
Significance of high-grade prostatic intraepithelial neoplasia on needle biopsy. (7684999)
1993
50
Remarks on a New Mode of Affording Permanent Relief to Intractable Chronic Cystitis, and to Confirmed Prostatic Retention of Urine. (20750395)
1882

Variations for Prostatitis

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Expression for genes affiliated with Prostatitis

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Expression patterns in normal tissues for genes affiliated with Prostatitis

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Pathways for genes affiliated with Prostatitis

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Pathways related to Prostatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3LTF, ELANE
2
Show member pathways
9.3KLK3, IL8

Compounds for genes affiliated with Prostatitis

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Compounds related to Prostatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1provenge4410.1KLK3, ACPP
2estracyt4410.1ACPP, KLK3
3chlormadinone acetate4410.1KLK3, ACPP
4cpsa4410.1KLK3, PROS1
5nilutamide44 61 28 1112.8ACPP, KLK3
6estramustine phosphate449.8KLK3, PROS1, ACPP
7goserelin44 28 1111.8KLK3, ACPP, PROS1
8estramustine44 1110.8PROS1, KLK3, ACPP
9apotransferrin449.7CP, LTF
10ferric ammonium citrate449.7LTF, CP
11dtpa449.7ACPP, CP, KLK3
12diethylstilbestrol44 28 1111.6LTF, ACPP, KLK3
13tenidap44 2810.6LTF, ELANE
14dihydrotestosterone44 28 24 1112.5ACPP, PROS1, KLK3
15ciprofloxacin44 50 1111.5KLK3, LTF, CP
16nimesulide44 1110.4LTF, ELANE
17sivelestat sodium hydrate449.4IL8, ELANE
18curosurf449.4IL8, ELANE
19survanta449.4IL8, ELANE
20sivelestat449.4IL8, ELANE
21dextran sulfate449.4LTF, ELANE, KLK3
22tlck449.3ELANE, IL8
23alpha tocopherol449.3CP, ELANE, KLK3
24cilomilast449.3ELANE, IL8
25thyroxine44 2410.1KLK3, ELANE, CP
26gabexate mesilate449.0IL8, ELANE
27indomethacin44 28 61 1112.0GDF15, LTF, PROS1, CP
28creatinine448.9PROS1, CP, LTF, ACPP
29n-formylmethionyl-leucylphenylalanine448.9IL8, LTF, ELANE
30pentoxifylline44 119.9ELANE, IL8, LTF
31citrate448.9CP, ELANE, ACPP, LTF
32leukotriene b444 61 2410.8ELANE, IL8, LTF
33ulinastatin448.7IL8, ELANE
34vitamin d448.6ACPP, CP, PROS1, ELANE, KLK3
35testosterone44 61 24 1111.6ELANE, PROS1, CP, ACPP, KLK3
36aprotinin44 119.6ELANE, LTF, KLK3, IL8
37hydrocortisone44 2 61 1111.6LTF, ELANE, IL8, KLK3
38neopterin448.6IL8, ELANE, ACPP, LTF
39hyaluronic acid44 249.6LTF, KLK3, IL8, ELANE
40fmlp448.5ELANE, IL8, LTF
41protamine448.4LTF, CP, ELANE, IL8
42endotoxin448.4LTF, IL8, ELANE
43superoxide44 249.3LTF, IL8, ELANE, CP
44dexamethasone44 50 28 1111.3KLK3, IL8, PROS1, CP, LTF
45lactate448.2KLK3, CP, ELANE, ACPP, IL8
46h2o2448.2IL8, LTF, CP, ELANE
47estrogen448.1LTF, GDF15, CP, ACPP, ELANE, KLK3
48heparin44 28 24 1111.0ELANE, IL8, PROS1, LTF, CP
49vegf447.9IL8, CP, ACPP, KLK3, LTF, PROS1
50serine446.9ELANE, KLK3, LTF, ACPP, PROS1, CP

GO Terms for genes affiliated with Prostatitis

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Cellular components related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301418.9ELANE, ACPP, LTF
2extracellular vesicular exosomeGO:0700628.4LTF, ACPP, ELANE, CP
3extracellular spaceGO:0056157.5GDF15, CP, ACPP, IL8, LTF
4extracellular regionGO:0055766.8LTF, KLK3, IL8, ELANE, PROS1, CP

Biological processes related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular protein metabolic processGO:0442678.9KLK3, IL8, PROS1

Molecular functions related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.0LTF, KLK3, ELANE

Products for genes affiliated with Prostatitis

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Sources for Prostatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet