MCID: PRS047
MIFTS: 62

Prostatitis malady

Summaries for Prostatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Prostatitis (less commonly prostatosis) is inflammation of the prostate gland. Prostatitis is classified... more...

MalaCards: Prostatitis is related to prostate cancer and adenocarcinoma. An important gene associated with Prostatitis is FOLH1 (folate hydrolase (prostate-specific membrane antigen) 1), and among its related pathways are Coregulation of Androgen receptor activity and Regulation of Androgen receptor activity. The drugs ciprofloxacin and norfloxacin and the compounds testosterone and dihydrotestosterone have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and breast.

Aliases & Classifications for Prostatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

prostatitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:14654
MeSH34 D011472
NCIt39 C26866
ICD9CM27 601.9, 601

Related Diseases for Prostatitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Prostatitis:



Diseases related to prostatitis

Clinical Features for Prostatitis

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Drugs & Therapeutics for Prostatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Prostatitis

Drug clinical trials:

Search ClinicalTrials for Prostatitis

Search NIH Clinical Center for Prostatitis

Search CenterWatch for Prostatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Prostatitis

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Anatomical Context for Prostatitis

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32MalaCards
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MalaCards organs/tissues related to Prostatitis:

32
Prostate, Bone, Breast, Endothelial, Testes, Lymph node, Lung, T cells, Bone marrow, Colon, Liver, Pituitary, Smooth muscle, Testis, Kidney, Skin, B cells, Brain, Monocytes, Heart, Ovary, Spinal cord, Myeloid, Thyroid, Placenta, Salivary gland, Pancreas, Cervix, Tongue, Adipocyte, Nk cells, Pineal, Appendix, Hypothalamus, Whole blood, Small intestine, Spleen, Uterus, Skeletal muscle

Animal Models for Prostatitis or affiliated genes

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Publications for Prostatitis

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50PubMed
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Articles related to Prostatitis:

(show top 50)    (show all 18416)
idTitleAuthorsYear
1
Insulin-like growth factor receptor-1 (IGF-IR) as a target for prostate cancer therapy. (24414227)
2014
2
IgG4-related prostatitis: a rare cause of steroid-responsive obstructive urinary symptoms. (23075137)
2013
3
IGFBP-3 nuclear localization predicts human prostate cancer recurrence. (23011725)
2013
4
Non-alcoholic fatty liver disease is associated with benign prostate hyperplasia in men and with overactive bladder in women. (23528112)
2013
5
Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer. (22363599)
2012
6
PDEF downregulates stathmin expression in prostate cancer. (22378487)
2012
7
Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells. (21940908)
2011
8
Physical activity and natural anti-VIP antibodies: potential role in breast and prostate cancer therapy. (22140573)
2011
9
Prostatitis: predictive value of post-massage urine leukocyte count for AIP. (20145661)
2010
10
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. (20541699)
2010
11
Association among polymorphisms in the steroid 5alpha-reductase type II (SRD5A2) gene, prostate cancer risk, and pathologic characteristics of prostate tumors in an Ecuadorian population. (19215786)
2009
12
Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. (18451159)
2008
13
Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer. (18196513)
2008
14
TGF-beta signaling and androgen receptor status determine apoptotic cross-talk in human prostate cancer cells. (18163430)
2008
15
Effects of anti-gene and antisense therapeutics on human prostate cancer xenograft in nude mice]. (19080439)
2008
16
Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer. (18384941)
2008
17
Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. (19047104)
2008
18
Prostate cancer-specific monoclonal antibody 5D4 significantly enhances the cytotoxicity of doxorubicin-loaded liposomes against target cells in vitro. (18686131)
2008
19
Quantitative detection of micrometastases in pelvic lymph nodes in patients with clinically localized prostate cancer by real-time reverse transcriptase-PCR. (17317829)
2007
20
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. (17510436)
2007
21
In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer. (17440096)
2007
22
Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers. (17242703)
2007
23
Chemoprevention of prostate cancer. Current status]. (17483928)
2007
24
Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. (16675569)
2006
25
Effect of PC-1 gene expression on migration ability of prostate cancer cells]. (16159422)
2005
26
Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. (15479493)
2004
27
Isolation and characterization of human and mouse WDR19,a novel WD- repeat protein exhibiting androgen-regulated expression in prostate epithelium. (12906858)
2003
28
Expression of biomarkers modulating prostate cancer angiogenesis: differential expression of annexin II in prostate carcinomas from India and USA. (14613585)
2003
29
Re: Chromogranin A concentration as a serum marker to predict prognosis after endocrine therapy for prostate cancer. (12771784)
2003
30
New paraoxonase 1 polymorphism I102V and the risk of prostate cancer in Finnish men. (12783936)
2003
31
Prostate cancer expression of runt-domain transcription factor Runx2, a key regulator of osteoblast differentiation and function. (12746842)
2003
32
Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails. (12686822)
2003
33
Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population. (12915880)
2003
34
Predicting prostate carcinoma volume and stage at radical prostatectomy by assessing needle biopsy specimens for percent surface area and cores positive for carcinoma, perineural invasion, Gleason score, DNA ploidy and proliferation, and preoperative serum prostate specific antigen: a report of 454 cases. (11391602)
2001
35
Ratio of free or complexed prostate-specific antigen (PSA) to total PSA: which ratio improves differentiation between benign prostatic hyperplasia and prostate cancer? (10620572)
2000
36
IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. (10840462)
2000
37
Human glandular kallikrein 2 expression in prostate adenocarcinoma and lymph node metastases. (10223487)
1999
38
BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy. (10379729)
1999
39
Influence of luteinizing hormone-releasing hormone analogues on serum levels of prostatic acid phosphatase and prostatic specific antigen in patients with metastatic carcinoma of the prostate. (10195870)
1998
40
Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer. (9446667)
1998
41
Absence of 185delAG mutation of the BRCA1 gene and 6174delT mutation of the BRCA2 gene in Ashkenazi Jewish men with prostate cancer. (9743298)
1998
42
Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinoma. (9637141)
1998
43
The effect of dihydrotestosterone on transcription of prostatic acid phosphatase mRNA in human hyperplastic gland. (9584855)
1997
44
Secondary mucinous adenocarcinoma of the prostate in a patient with ulcerative colitis. (8389496)
1993
45
Species differences in 5 alpha-androstane-3 beta,17 beta-diol hydroxylation by rat, monkey, and human prostate microsomes. (1378714)
1992
46
Sclerosing adenosis of the prostate gland. A lesion showing myoepithelial differentiation. (1373581)
1992
47
Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin. (1716536)
1991
48
CT features of perirectal fascia thickening after transurethral resection of prostatic adenoma. (2433317)
1987
49
Mucinous adenocarcinoma of the prostate. (195095)
1977
50
Papillomatosis and papillary adenocarcinoma of prostatic ducts: a case report. (5532917)
1970

Genetic Variations for Prostatitis

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Expression for genes affiliated with Prostatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Prostatitis

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Pathways for genes affiliated with Prostatitis

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Prostatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3PAWR, KLK3, KLK2
211.3SPDEF, KLK3, KLK2
311.0KLK3, KLK2

Compounds for genes affiliated with Prostatitis

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Prostatitis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2415.3KLK2, KLK3, FOLH1, ACPP, MSMB, SPDEF
2dihydrotestosterone44 28 11 2415.1SPDEF, ACPP, FOLH1, KLK3, KLK2
3prostascint4411.3KLK3, FOLH1
4provenge4411.3ACPP, KLK3
5heme28 11 2413.3STEAP4, STEAP2, STEAP1
6estracyt4411.3ACPP, KLK3
7chlormadinone acetate4411.2ACPP, KLK3
8estramustine phosphate4411.2KLK3, ACPP
9goserelin44 28 1113.2ACPP, KLK3
10nilutamide44 59 28 1114.2ACPP, KLK3
11buserelin44 28 1113.1KLK3, ACPP
12estramustine44 1112.1KLK3, ACPP
13finasteride44 59 11 2414.0KLK3, ACPP
14dtpa4410.9ACPP, KLK3
15cyproteroneacetate4410.7ACPP, KLK3

GO Terms for genes affiliated with Prostatitis

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16Gene Ontology
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Cellular components related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:01000811.3PARM1, STEAP2, STEAP1

Biological processes related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681111.3STEAP4, STEAP2, STEAP1
2iron ion homeostasisGO:05507211.0STEAP4, STEAP2, STEAP1

Molecular functions related to Prostatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transporter activityGO:00521511.3SYT7, STEAP2, STEAP1
2oxidoreductase activityGO:01649111.0STEAP4, STEAP2, STEAP1

Products for genes affiliated with Prostatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Prostatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet