Protein C Deficiency malady

Genetics Home Reference: Protein C deficiency is a disorder of blood clotting. People with this condition have an increased risk of developing abnormal blood clots.¹⁷

MalaCards: Protein C Deficiency, also known as hereditary thrombophilia due to protein c deficiency, is related to thrombosis and surfactant protein c deficiency. An important gene associated with Protein C Deficiency is PROC (protein C (inactivator of coagulation factors Va and VIIIa)), and among its related pathways are Cell surface interactions at the vascular wall and Common Pathway. The compounds ximelagatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lung and skin, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia: Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. It was first...⁴⁴ more...

Aliases & Descriptions:

protein c deficiency 6 44 16 17 8 32 43 hereditary thrombophilia due to protein c deficiency 17

thrombophilia, hereditary 43

Disease types for protein s deficiency family:

protein c deficiency	protein r deficiency

Diseases related to protein c deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 361)

id	Related Disease	Score	Top Affiliating Genes
1	thrombosis	33.2	SERPINA10, MTHFR, F8, F5, F2
2	surfactant protein c deficiency	32.4	SFTPC, TLR3
3	purpura fulminans	29.4	SERPINC1, MTHFR, APOH, F5, F3, F2
4	protein s deficiency	28.9	SERPINC1, F9, F5
5	interstitial lung disease	28.4	SFTPC, SERPINC1, F5, PROC, CSF3
6	arterial occlusive disease	28.3	MTHFR, F3, CBS, THBD
7	cerebrovascular accident	27.2	SERPINC1, SERPINE1, MTHFR, APOH, F7, F5
8	venous thrombosis	26.7	SERPINC1, SERPINF2, SERPINA10, SERPINE1, MTHFR, JAK2
9	thrombophlebitis	26.7	SERPINC1, SERPINF2, MTHFR, APOH, F8, F5
10	septic shock	26.7	SERPINC1, SERPINE1, CFP, FGA, F5, F3
11	meningitis	26.7	CFP, APOH, F5, F13A1, PLAU, CSF3
12	hyperhomocysteinemia	26.5	SERPINC1, SERPINE1, MTHFR, APOH, F9, F8
13	purpura	26.4	SERPINC1, SERPINF2, SERPINE1, MTHFR, APOH, F9
14	antithrombin iii deficiency	26.4	SERPINC1, SERPIND1, MTHFR, JAK2, FGA, APOH
15	thromboembolism	25.8	SERPINC1, SERPINF2, SERPIND1, SERPINE1, MTHFR, FGA
16	sepsis	24.4	SERPINC1, SERPINF2, SERPINE1, FGA, F9, F7
17	cerebral infarction	23.7	SERPINC1, SERPIND1, SERPINE1, MTHFR, FGA, APOH
18	immunodeficiency	23.5	SFTPC, SERPINC1, SERPINE1, CFP, APOH, F9
19	deep vein thrombosis	22.6	SERPINC1, SERPINE1, MTHFR, FGA, APOH, F9
20	thrombophilia	21.7	SERPINC1, SERPINF2, SERPIND1, SERPINA10, SERPINE1, MTHFR
21	leukemia	19.3	SERPINC1, SERPINF2, SERPINE1, MTHFR, CFP, JAK2
22	myocardial infarction	19.2	SERPINC1, SERPINF2, SERPIND1, SERPINA10, SERPINA4, SERPINE1
23	cerebritis	19.2	SERPINC1, SERPINF2, SERPIND1, SERPINE1, MTHFR, JAK2
24	mondor disease	13.7	APOH, F5
25	antiphospholipid syndrome	13.7	APOH, F2
26	placental infarction	13.7	SERPINC1, APOH, F5
27	stroke, ischemic	13.7	F5, F2
28	legg-calve-perthes disease	13.7	SERPINC1, F5
29	postphlebitic syndrome	13.7	SERPINC1, F5
30	placental abruption	13.6	SERPINC1, MTHFR, F5
31	vitamin k-dependent clotting factors	13.6	F9, F5, F2
32	blood protein disease	13.6	MTHFR, F5, F2
33	porencephaly	13.6	MTHFR, F5, F2
34	hepatic vein thrombosis	13.6	SERPINC1, SERPINE1
35	homocysteine plasma level	13.6	SERPINC1, MTHFR, F5
36	neonatal stroke	13.6	SERPINE1, MTHFR, F5
37	mthfr deficiency	13.6	MTHFR, CBS
38	acquired angioedema	13.6	SERPINC1, F5
39	retinal vascular occlusion	13.6	SERPINC1, MTHFR, APOH, F5
40	gastroschisis	13.6	MTHFR, F5, F2
41	infective endocarditis	13.5	SERPINC1, APOH, F2
42	amaurosis fugax	13.5	SERPINE1, MTHFR, APOH, F5
43	critical limb ischemia	13.5	APOH, F5, THBD
44	hyperprothrombinemia	13.5	SERPINC1, F2
45	homocysteinemia	13.5	MTHFR, F5, CBS
46	intracranial hypertension	13.5	SERPINC1, SERPINE1, APOH, F5
47	collagen disease	13.5	APOH, COL1A1, THBD
48	ischemic optic neuropathy	13.5	MTHFR, APOH, F5, F2
49	severe pre-eclampsia	13.5	SERPINC1, SERPINE1, APOH, F5
50	transient cerebral ischemia	13.5	MTHFR, FGA, APOH

Approved drugs:

Drug clinical trials:

Genetic tests related to protein c deficiency:

id	Genetic test	Affiliating Genes
1	Protein C Deficiency clinical/research	PROC

MalaCards organs/tissues related to protein c deficiency:

²²

MGI Mouse Phenotypes related to protein c deficiency:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.2	PAFAH1B2, TLR3
2	respiratory system phenotype	MP:0005388	9.8	F13A1, CBS, SFTPC
3	embryogenesis phenotype	MP:0005380	9.3	PROCR, COL1A1, CBS, F2, PAFAH1B2, SERPINC1
4	hematopoietic system phenotype	MP:0005397	9.3	CSF3, PROCR, COL1A1, HRG, F13A1, SERPIND1
5	liver/biliary system phenotype	MP:0005370	9.2	PLG, ONECUT1, CBS, F9, FGA, FOXM1
6	integument phenotype	MP:0010771	8.7	CSF3, COL1A1, CBS, F2, F3, F5
7	reproductive system phenotype	MP:0005389	8.7	TLR3, PLG, CBS, F8, FGA, PAFAH1B2
8	immune system phenotype	MP:0005387	8.2	PROC, TLR3, COL1A1, PLG, ONECUT1, CBS
9	tumorigenesis	MP:0002006	7.6	TLR3, COL1A1, PLG, PLAU, F3, FOXM1
10	vision/eye phenotype	MP:0005391	7.6	COL1A1, PLG, PLAU, CBS, F3, FGA
11	nervous system phenotype	MP:0003631	7.0	PLAU, PLG, COL1A1, TLR3, THBD, PROC
12	growth/size phenotype	MP:0005378	6.8	PROCR, THBD, COL1A1, PLG, PLAU, ONECUT1
13	cardiovascular system phenotype	MP:0005385	5.8	F2, CBS, F13A1, ONECUT1, PLAU, PLG
14	mortality/aging	MP:0010768	4.0	ONECUT1, F13A1, CBS, F2, F3, PLAU
15	homeostasis/metabolism phenotype	MP:0005376	3.2	PROCR, F2, CBS, F12, F13A1, HRG

Articles related to protein c deficiency:

(show top 50)    (show all 103)

id	Title	Authors	Year	Affiliating Genes
1	Protein C deficiency in Thai children with thromboemb olism: A report of clinical presentations and mutation analysis. (19922983)	Sirachainan N.... Parapakpenjune S.	2010	PROC
2	Hereditary protein C deficiency caused by the Ala267T hr mutation in the protein C gene is associated with symptomatic and asymptomat ic venous thrombosis. (19535131)	Tjeldhorn L.... Skretting G.	2010	PROC
3	Definite diagnosis in Japanese patients with protein C deficiency by identification of causative PROC mutations. (19373522)	Takagi A.... Kojima T.	2009	PROC
4	Fulminant sepsis/meningitis due to Haemophilus influe nzae in a protein C-deficient heterozygote treated with activated protein C the rapy. (18751723)	Ishimura M.... Hara T.	2009	F5
5	Severe purpura fulminans due to coexistence of homozy gous protein C deficiency and homozygous methylenetetrahydrofolate reductase mu tation. (19954370)	Demirel N.... Yarali N.	2009	MTHFR
6	Activated protein C concentrate treatment for skin necrosis under warfarin treatment in severe genetic protein C deficiency combined with prothrombin mutation and factor V Leiden. (19190829)	Rosenzweig N.... Kenet G.	2009	F2, PROC, F5
7	A model for the formation, growth, and lysis of clots in quiescent plasma. A comparison between the effects of antithrombin III deficiency and protein C deficiency. (18539301)	Anand M.... Rajagopal K.R.	2008	SERPINC1
8	Protein C deficiency in a family with thromboembolism and identified gene mutations. (17603240)	Hoshi S.... Yamaguchi T.	2007	PROC
9	Molecular mechanisms of protein C deficiency caused by C64W and F139V mutations (17649706)	Zhou R.F.... Wang H.	2007	PROC
10	Severe clinical presentation of protein C deficiency in a type I/II compound heterozygote newborn. (16113807)	Fernandez-Burriel M.	2005	PROC
11	Heritability of plasma concentrations of clotting factors and measures of a prethrombotic state in a protein C-deficient family. (14995985)	Vossen C.Y.... Bovill E.G.	2004	F9, FGA, SERPINA10
12	Bacteroides fragilis bacteremia associated with portal vein and superior mesentery vein thrombosis secondary to antithrombin III and protein C deficiency: a case report. (12542252)	Ni Y.H.... Chang F.Y.	2002	SERPINC1
13	Perioperative management of a patient with purpura f ulminans syndrome due to protein C deficiency (11744581)	Kumagai K.... Shimada Y.	2001	F5
14	Molecular genetic analysis of severe protein C deficiency. (10942114)	Millar D.S.... Cooper D.N.	2000	PROC
15	Jejunal stricture complicating acute mesenteric venous thrombosis secondary to protein C deficiency and factor V Leiden gene mutation. (10812821)	Narawane N.M.... Abraham P.	2000	F5
16	Single founder mutation (W380G) in type II protein C deficiency in Finland. (11019966)	Levo A.... Partanen J.	2000	PROC
17	Mesenteric venous thrombosis associated with protein C deficiency. (10433018)	Mitani M.... Fujii Y.	1999	SERPINC1
18	Type-I protein-C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein-C gene promoter. (10578522)	Spek A.... Reitsma P.	1999	ONECUT1
19	Can low level of von Willebrand factor decrease the risk of thrombosis in families with antithrombin or protein C deficiency? (10365764)	Jelenska M.M.... Zajac S.	1999	SERPINC1
20	Screening methods in genetic diagnosis of hereditary protein C deficiency (9990817)	DA!vid M.... Meyer M.	1999	SERPINF2
21	Analysis of 45 episodes of arterial occlusive disease in Japanese patients with congenital protein C deficiency. (10230891)	Sakata T.... Miyata T.	1999	SERPINC1
22	Three novel PROC gene lesions causing protein C deficiency. (9788727)	Hallam P.J.... Cooper D.N.	1998	PROC
23	Activated protein C concentrate: a new tool for the t reatment of acute thromboembolism in patients with congenital protein C deficie ncy. (9241766)	Sugimoto M.... Yoshioka A.	1997	F5
24	Ectopic transcript analysis indicates that allelic exclusion is an important cause of type I protein C deficiency in patients with nonsense and frameshift mutations in the PROC gene. (8822578)	Soria J.M.... Sala N.	1996	PROC
25	Recurrence of the PROC gene mutation R178Q: independent origins in Spanish protein C deficiency patients. (8807339)	Soria J.M.... Sala N.	1996	PROC
26	Homozygosity for R87H missense mutation and for a rare intron 7 DNA variant (7054G --> A) in the PROC genes of three siblings initially classified as heterozygotes for protein C deficiency. (8845458)	Soria J.M.... Sala N.	1996	PROC
27	Six different point mutations in seven Danish families with symptomatic protein C deficiency. (7792728)	Lind B.... Thorsen S.	1995	PROC
28	Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study) (7742536)	Koster T.... Vandenbroucke J.P.	1995	SERPINC1
29	Population differences in the frequency of the factor V Leiden variant among people with clinically symptomatic protein C deficiency . (7562967)	Hallam P.J.... Cooper D.N.	1995	F5
30	Severe type I protein C deficiency in a compound heterozygote for Y124C and Q132X mutations in exon 6 of the PROC gene. (8607097)	Soria J.M.... Sala N.	1995	PROC
31	Two mutations in the promoter region of the human protein C gene both cause type I protein C deficiency by disruption of two HNF-3 binding sites. (7592627)	Spek C.A.... Reitsma P.H.	1995	FOXM1
32	Superficial migratory thrombophlebitis in a patient w ith reversible protein C deficiency and anticardiolipin antibodies. (7864700)	Fiehn C.... Hunstein W.	1994	APOH
33	Protein C and S deficiency, thrombophilia, and hypofibrinolysis: pathophysiologic causes of Legg-Perthes disease. (8047373)	Glueck C.J.... Tracy T.	1994	SERPINC1, SERPINF2
34	Symptomatic type II protein C deficiency caused by a missense mutation (Gly 381-->Ser) in the substrate-binding pocket. (8398832)	Marchetti G.... Bernardi F.	1993	PROC
35	Genetic mutations in ten unrelated American patients with symptomatic type 1 protein C deficiency. (8292730)	Tsay W.... Griffin J.H.	1993	PROC
36	Protein C deficiency: a database of mutations. (8446940)	Reitsma P.H.... Cooper D.N.	1993	PROC
37	A Gla domain mutation (Arg 15-->Trp) in the protein C (PROC) gene causing type 2 protein C deficiency and recurrent venous thrombosis. (8499568)	Millar D.S.... Cooper D.N.	1993	PROC
38	Thrombotic complications of BMT: association with protein C deficiency. (8431711)	Gordon B.G.... Reed E.C.	1993	PROC
39	The clinical characteristics, complications and therapeutic problems of protein C deficiency (8211782)	Barkagan Z.S.... Karpenko A.A.	1993	SERPINC1
40	Successful treatment of deep vein thrombosis in homoz ygous protein C deficiency with activated protein C. (8213784)	Wada H.... Suzuki K.	1993	F5
41	Increased thrombin generation in a child with a combined factor IX and protein C deficiency. (8427961)	Negrier C.... Dechavanne M.	1993	F9
42	Familial cerebrovascular accidents due to concomitant hyperhomocysteinemia and protein C deficiency type 1. (8378967)	Franken D.G.... Novakova I.R.	1993	THBD
43	Homozygous protein C deficiency: identification of a novel missense mutation that causes impaired secretion of the mutant protein C. (1593215)	Yamamoto K.... Saito H.	1992	PROC
44	Hereditary protein C-deficiency: laboratory values in transmitters and guidelines for the diagnostic procedure. Report on a study of the SSC Subcommittee on Protein C and Protein S. Protein C Transmitter Study G roup. (1448781)	Pabinger I.... Bertina R.M.	1992	XAGE2
45	Impaired secretion of the elongated mutant of protein C (protein C-Nagoya). Molecular and cellular basis for hereditary protein C deficiency. (1469096)	Yamamoto K.... Saito H.	1992	PROC
46	Genetic analysis of congenital protein C deficiency (1433913)	Yamamoto S.... Matsushita T.	1992	PROC
47	Protein C deficiency Hong Kong 1 and 2: hereditary protein C deficiency caused by two mutant alleles, a 5-nucleotide deletion and a missense mutation. (1611081)	Sugahara Y.... Aoki N.	1992	PROC
48	The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects. (1868249)	Reitsma P.H.... Bertina R.M.	1991	PROC
49	Familial variant of antithrombin III (AT III Bligny, 47Arg to His) associated with protein C deficiency. (2363123)	Wolf M.... Larrieu M.J.	1990	SERPINC1
50	Protein C deficiency and anticardiolipin antibodies i n a family with premature stroke. (2293763)	Haire W.D.... Newland J.R.	1990	APOH

Genes related to protein c deficiency according to GeneCards:

(show all 38)

id	Symbol	Description	Score	GeneCards Section Context
1	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.1	Summaries, Publications
2	SFTPC	surfactant protein C	11.1	Summaries, Publications
3	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
4	PROCR	protein C receptor, endothelial	11.0
5	FOXM1	forkhead box M1	11.0	Publications
6	HRG	histidine-rich glycoprotein	11.0	Publications
7	F9	coagulation factor IX	11.0	Publications
8	THBD	thrombomodulin	11.0	Publications
9	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
10	TLR3	toll-like receptor 3	11.0	Publications
11	CFP	complement factor properdin	11.0	Publications
12	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
13	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
14	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
15	F2	coagulation factor II (thrombin)	11.0	Publications
16	XAGE2	X antigen family, member 2	11.0	Publications
17	SERPINA4	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	11.0	Publications
18	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	11.0	Publications
19	PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	11.0	Publications
20	ONECUT1	one cut homeobox 1	11.0	Publications
21	SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	11.0
22	ENGASE	endo-beta-N-acetylglucosaminidase	11.0
23	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
24	COL1A1	collagen, type I, alpha 1	11.0	Publications
25	INSC	inscuteable homolog (Drosophila)	11.0	Disorders
26	FGA	fibrinogen alpha chain	11.0	Publications
27	F12	coagulation factor XII (Hageman factor)	11.0
28	PF4	platelet factor 4	11.0	Publications
29	CBS	cystathionine-beta-synthase	11.0	Publications
30	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0
31	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
32	PLG	plasminogen	11.0
33	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
34	ADAMTSL1	ADAMTS-like 1	11.0	Publications
35	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
36	F8	coagulation factor VIII, procoagulant component	11.0
37	JAK2	Janus kinase 2	11.0
38	PLAU	plasminogen activator, urokinase	11.0	Publications

Pathways related to protein c deficiency according to GeneDecks:

(show all 17)

id	Pathway	Score	Top Affiliating Genes
1	Cell surface interactions at the vascular wall38	10.1	PROC, THBD, F2
2	Common Pathway38	10.1	F13A1, F5, SERPINC1
3	Warfarin Pathway, Pharmacodynamics34	10.0	F9, F7, F2, PROC
4	Selected targets of C/EBPalpha10	9.8	F9, FOXM1, SERPINC1
5	Platelet activation, signaling and aggregation38	9.6	FGA, PLG, PF4
6	Selected targets of HNF110	9.4	APOH, F8, F13A1, PROC
7	Response to elevated platelet cytosolic Ca2+38	9.4	SERPINF2, F8, HRG
8	Cell adhesion_ECM remodeling41	9.3	COL1A1, PLG, PLAU, SERPINE1
9	Cell adhesion ECM remodeling10	9.3	COL1A1, PLG, PLAU, SERPINE1
10	Cell adhesion_Plasmin signaling41	9.3	PLG, PLAU, F12, FGA
11	Cell adhesion Plasmin signaling10	9.2	PLG, PLAU, F12, FGA
12	UPA-UPAR Pathway36	8.4	COL1A1, PLG, PLAU, JAK2, SERPINE1
13	Extrinsic Prothrombin Activation Pathway36	8.4	PROC, THBD, F13A1, F12, F2, F3
14	Intrinsic Prothrombin Activation Pathway36	8.2	F9, FGA, SERPINC1, F8, F5, F2
15	Blood Coagulation Cascade36	7.4	PROC, THBD, COL1A1, F13A1, F12, F2
16	Blood Coagulation Signaling Pathways37	6.4	PROC, THBD, PLG, PLAU, F13A1, F12
17	Complement and coagulation cascades20	6.1	PLG, PLAU, F13A1, F12, F2, F3

Compounds related to protein c deficiency according to GeneDecks:

(show top 50)    (show all 201)

id	Compound	Score	Top Affiliating Genes
1	ximelagatran32 9 9	12.2	F2, SERPINC1
2	hirugen32	10.0	THBD, F2, F5, FGA, SERPINC1
3	ancrod32	9.9	F2, THBD, SERPINC1, F5, FGA, SERPINE1
4	cyclophosphamide32 34 9 9	12.7	F8, APOH, F9
5	fibrinopeptide a32	9.7	PF4, SERPINF2, SERPINC1, FGA, THBD, F2
6	ristocetin32	9.6	F8, SERPINC1, F2, F9, SERPINF2
7	bivalirudin32 9 9	11.5	F3, THBD, F2, SERPINC1, F5, FGA
8	argatroban32 9 9	11.5	F3, F2, FGA, SERPINC1, F5, THBD
9	danaparoid32	9.5	F5, F3, F2, PF4, SERPINC1
10	11-dehydrothromboxane b232	9.5	THBD, PF4, CBS, F2, APOH, FGA
11	fondaparinux32	9.4	SERPINC1, F9, F5, F3, F2, PF4
12	heparinoids32	9.4	THBD, F2, F3, F5, SERPINC1, F13A1
13	Drotrecogin alfa9 9	10.3	THBD, PF4, F2, F5, F8, SERPINE1
14	benzamidine32 9 9	11.3	F9, SERPINC1, THBD, PLG, PLAU, F5
15	cysteine32	9.2	THBD, PF4, HRG, COL1A1, PLAU, MTHFR
16	lysine32	9.1	SFTPC, SERPINF2, PLAU, PF4, F13A1
17	gamma-carboxyglutamic acid32	9.0	F3, F2, PF4, THBD, PROC, PROCR
18	pge132	9.0	PF4, F2, PLAU, THBD, FGA, APOH
19	cacl232	9.0	F3, F9, F5, F8, FGA, THBD
20	kaolin32	9.0	APOH, F9, F8, F5, F3, F2
21	ptca32	8.8	SERPINF2, FGA, APOH, F3, PF4, THBD
22	protamine32	8.7	SERPINC1, SERPINE1, ADAMTSL1, PF4, F2, F3
23	hydroxyethyl starch32	8.7	CSF3, F2, F3, F8, SERPINC1
24	txb232	8.6	APOH, FGA, SERPINF2, F3, PF4, THBD
25	dermatan sulfate32	8.6	F5, F3, F2, HRG, PLAU, PF4
26	hirudin32	8.6	ADAMTSL1, PROCR, THBD, PF4, PLAU, F5
27	homocysteine32 18	9.5	APOH, SERPINE1, SERPINC1, F9, F8, THBD
28	aprotinin32 9 9	10.4	THBD, PF4, PLG, PLAU, F2, F5
29	aspartate32	8.3	F2, F7, ADAMTSL1, F5, THBD, F8
30	tranexamic acid32 9 9	10.3	SERPINC1, SERPINE1, F9, F8, F3, F2
31	desmopressin32 42 9 9	11.2	SERPINC1, SERPINF2, PLAU, THBD, F2, F3
32	epsilon aminocaproic acid32	8.1	SERPINC1, SERPINF2, SERPINE1, F9, F3, F2
33	warfarin32 34 9 18 9	11.9	F5, F7, F8, F9, APOH, FGA
34	nacl32	7.7	THBD, PF4, PLG, HRG, F5, F8
35	dextran sulfate32	7.6	PF4, ADAMTSL1, PLAU, SERPINC1, CFP, JAK2
36	prostacyclin32	7.5	SERPINE1, SERPINC1, F5, F8, APOH, FGA
37	phospholipid32	7.3	SERPINA10, F8, JAK2, SFTPC, F9, F5
38	endotoxin32	7.2	F3, TLR3, THBD, PROCR, CSF3, F5
39	polysaccharide32	7.2	THBD, PF4, PLAU, F3, F5, F8
40	creatinine32	7.2	APOH, FGA, F9, F7, F8, F5
41	epinephrine32 9 18 9	10.1	JAK2, PLAU, F2, F3, ADAMTSL1, F5
42	cholesterol32 9 18 9	9.6	SERPINF2, SERPINE1, SFTPC, FGA, ADAMTSL1, MTHFR
43	kininogen32	6.3	F13A1, HRG, PLAU, PLG, PF4, THBD
44	alanine32	6.3	THBD, PF4, COL1A1, PLAU, F2, F3
45	estrogen32	6.2	SERPINE1, PLAU, FOXM1, F13A1, F12, F2
46	aspirin32 34 18	8.2	SERPINE1, MTHFR, JAK2, FGA, APOH, F8
47	heparin32 9 18 9	8.9	ADAMTSL1, PROC, PLG, PLAU, HRG, F13A1
48	vegf32	5.0	COL1A1, PLG, PLAU, F13A1, F3, F5
49	fibrinogen32	4.6	ADAMTSL1, PROCR, PROC, THBD, PF4, PLG
50	serine32	4.0	F5, F7, F8, F9, FGA, JAK2

Cellular components related to protein c deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:005796	9.8	F9, F7, F2, PROC
2	endoplasmic reticulum lumen	GO:005788	9.2	PROC, COL1A1, F2, F7, F9
3	extracellular matrix	GO:031012	9.2	COL1A1, F3, APOH, CFP, SERPINE1
4	platelet alpha granule lumen	GO:031093	8.0	SERPINF2, SERPINE1, FGA, F8, F5, F13A1
5	extracellular region	GO:005576	5.5	F2, F12, F13A1, HRG, PLAU, PLG
6	extracellular space	GO:005615	5.3	SFTPC, PF4, THBD, PROC, CSF3, COL1A1

Biological processes related to protein c deficiency according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of blood coagulation	GO:030195	10.2	PROC, THBD, APOH, SERPINE1
2	negative regulation of cell adhesion mediated by integrin	GO:033629	10.2	SERPINE1, HRG
3	negative regulation of plasminogen activation	GO:010757	10.2	SERPINE1, SERPINF2
4	peptidyl-glutamic acid carboxylation	GO:017187	10.0	F9, F7, F2, PROC
5	positive regulation of fibrinolysis	GO:051919	9.9	PLG, F12
6	leukocyte migration	GO:050900	9.9	F2, COL1A1, THBD, PROC
7	positive regulation of platelet-derived growth factor receptor signaling pathway	GO:010641	9.8	F7, F3
8	blood coagulation, extrinsic pathway	GO:007598	9.8	F9, F7, F3
9	positive regulation of blood coagulation	GO:030194	9.7	F12, F2, F7, APOH, SERPINE1
10	negative regulation of fibrinolysis	GO:051918	9.5	THBD, SERPINF2, SERPINE1, APOH, F2, HRG
11	blood coagulation, intrinsic pathway	GO:007597	9.5	F12, F2, F8, F9, APOH
12	positive regulation of tumor necrosis factor production	GO:032760	9.4	JAK2, PF4, TLR3
13	acute-phase response	GO:006953	9.4	F2, F8, SERPINF2
14	fibrinolysis	GO:042730	9.0	PLG, PLAU, HRG, F12, F2, SERPINE1
15	proteolysis	GO:006508	8.8	PROC, PLG, PLAU, F12, F2, F7
16	positive regulation of cell migration	GO:030335	8.6	COL1A1, ONECUT1, F3, F7, JAK2
17	response to lipopolysaccharide	GO:032496	8.6	SFTPC, JAK2, F3, THBD
18	platelet degranulation	GO:002576	8.2	PF4, PLG, HRG, F13A1, F5, F8
19	platelet activation	GO:030168	7.8	PF4, COL1A1, PLG, HRG, F13A1, F2
20	blood coagulation	GO:007596	4.6	PLG, COL1A1, PF4, THBD, PROC, PROCR

Molecular functions related to protein c deficiency according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic cell surface binding	GO:043499	9.9	SERPINF2, FGA, APOH
2	heparin binding	GO:008201	9.6	PF4, HRG, APOH, SERPIND1, SERPINC1
3	serine-type endopeptidase inhibitor activity	GO:004867	9.5	HRG, SERPINE1, SERPINF2, SERPINC1
4	protease binding	GO:002020	9.5	F3, SERPINE1, SERPINF2, SERPINC1
5	cell surface binding	GO:043498	9.4	F3, HRG, PLG
6	serine-type endopeptidase activity	GO:004252	8.8	F9, PROC, PLG, PLAU, F12, F2
7	protein binding	GO:005515	5.1	CBS, F12, HRG, PLAU, PLG, COL1A1