PEM
MCID: PRT038
MIFTS: 45

Protein-Energy Malnutrition (PEM) malady

Summaries for Protein-Energy Malnutrition

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66Wikipedia, 34MalaCards
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Wikipedia:66 Protein?energy malnutrition (PEM) or protein?calorie malnutrition refers to a form of malnutrition where... more...

MalaCards: Protein-Energy Malnutrition, also known as PEM, is related to hepatitis and liver cirrhosis. An important gene associated with Protein-Energy Malnutrition is PIGR (polymeric immunoglobulin receptor), and among its related pathways are Diseases associated with visual transduction and Visual Cycle in Retinal Rods. The compounds styrene and purpurin have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and testes, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Protein-Energy Malnutrition

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9Disease Ontology, 11DISEASES, 46Novoseek, 40NCBI Bookshelf, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 41NCIt, 26ICD10
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Classifications:



Aliases & Descriptions:

protein-energy malnutrition 9 11 46 63
pem 40


External Ids:

Disease Ontology9 DOID:11801
MeSH36 D011502
ICD9CM28 263.9
NCIt41 C34952
ICD1026 E46

Related Diseases for Protein-Energy Malnutrition

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Protein-Energy Malnutrition:



Diseases related to protein-energy malnutrition

Symptoms for Protein-Energy Malnutrition

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Drugs & Therapeutics for Protein-Energy Malnutrition

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Protein-Energy Malnutrition

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Anatomical Context for Protein-Energy Malnutrition

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34MalaCards
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MalaCards organs/tissues related to Protein-Energy Malnutrition:

34
Bone, Liver, Testes, Brain, Thyroid, Bone marrow, Thymus, Small intestine, T cells, Skeletal muscle, Heart, B cells, Skin, Kidney, Placenta, Pancreas, Colon, Pituitary

Animal Models for Protein-Energy Malnutrition or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Protein-Energy Malnutrition:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.5RBP4, CCK, EPHX1, TTR, PIGR

Publications for Protein-Energy Malnutrition

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53PubMed
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Articles related to Protein-Energy Malnutrition:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
A narrative review of recent progress in understanding the relationship between tuberculosis and protein energy malnutrition. (23942176)
2013
2
Protein-energy malnutrition alters IgA responses to rotavirus vaccination and infection but does not impair vaccine efficacy in mice. (24200975)
2013
3
Hepatoprotective and nephroprotective effects of Cnidoscolus aconitifolius in protein energy malnutrition induced liver and kidney damage. (24174819)
2013
4
Evaluating risk factors for protein-energy malnutrition in children under the age of six years: a case-control study from Iran. (21887115)
2011
5
Protein-energy malnutrition alters hippocampal plasticity-associated protein expression following global ischemia in the gerbil. (20883206)
2010
6
Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition. (20036516)
2010
7
Serum ghrelin in infants with protein-energy malnutrition. (19261361)
2009
8
Serum ghrelin levels in children with primary protein-energy malnutrition. (18937750)
2008
9
Current prevalence and predictors of protein-energy malnutrition among schoolchildren in rural Peninsular Malaysia. (19058591)
2008
10
Effect of protein-energy malnutrition on erythropoietin requirement in maintenance hemodialysis patients. (17403171)
2007
11
Protein-energy malnutrition alters histological and ultrastructural characteristics of the bone marrow and decreases haematopoiesis in adult mice. (17357095)
2007
12
Detection of severe protein-energy malnutrition by nurses in The Gambia. (14736639)
2004
13
An evaluation of re-orientation training program of ICDS functionaries on protein-energy malnutrition. (11439866)
2000
14
Micronutrient deficiencies and protein-energy malnutrition. (9635975)
1998
15
Effects of protein-energy malnutrition on muscarinic receptor density and acetylcholinesterase activity in rat brain. (9195001)
1997
16
Vitamin E status in protein energy malnutrition. (23100878)
1997
17
Correction of protein-energy malnutrition in older adults: effects of a short-term aerobic training program. (16844611)
1997
18
Profile of protein energy malnutrition amongst children under four years in urban areas of Rivers State. (8652441)
1996
19
The clinical assessment of adult patients with protein energy malnutrition. (7659057)
1995
20
The computed axial tomography of the brain in protein energy malnutrition. (8687211)
1995
21
Protein-energy malnutrition: its effects on 4 metabolic parameters]. (7612711)
1995
22
Protein energy malnutrition in severe alcoholic hepatitis: diagnosis and response to treatment. The VA Cooperative Study Group #275. (8523623)
1995
23
Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. (7491893)
1995
24
Computerized cry analysis in infants affected by severe protein energy malnutrition. (8193504)
1994
25
Protein-energy malnutrition in cystic fibrosis patients. (8025359)
1994
26
Management of protein-energy malnutrition in Nigeria: an evaluation of the regimen at the Kersey Nutrition Rehabilitation Centre, Nigeria. (7992350)
1994
27
Diabetes in pregnancy: fetal macrosomia, hyperinsulinism, and islet hyperplasia in the offspring of rats subjected to temporary protein-energy malnutrition early in life. (8108195)
1993
28
The worldwide magnitude of protein-energy malnutrition: an overview from the WHO Global Database on Child Growth. (8313488)
1993
29
Ultrastructure of the islets of Langerhans in protein-energy malnutrition. (8273316)
1993
30
Sex-hormone-binding globulin and protein-energy malnutrition indexes as indicators of nutritional status in women with anorexia nervosa. (8438764)
1993
31
Skeletal muscle wasting and protein-energy malnutrition in children with a newly diagnosed acute leukemia. (2114940)
1990
32
Vitamin E status in Sudanese children with protein-energy malnutrition. (2110395)
1990
33
Value of serum transthyretin measurements in the assessment of marginal protein-energy malnutrition in rats. (2457071)
1988
34
Arm circumference as an index of protein-energy malnutrition in six- to eleven-month old rural Tanzanian children. (3146648)
1988
35
Hair root morphology as an index of protein energy malnutrition. (3149675)
1988
36
Protein-energy malnutrition increases teratogenicity of hypervitaminosis A in rats. (3147800)
1988
37
Gestational protein-energy malnutrition affects the composition of developing skins of rat fetuses and their dams. (3118938)
1987
38
Classification of protein-energy malnutrition in industrialized countries. (3090869)
1986
39
Protein-energy malnutrition and risk of infection. (3099300)
1986
40
Small bowel function in mild to moderate protein-energy malnutrition. (3100443)
1986
41
Effect of protein-energy malnutrition on drug metabolism in man. (6433561)
1984
42
Plasma lipids and lipoprotein cholesterol in undernourished diabetic subjects and adults with protein energy malnutrition. (6439533)
1984
43
Protein-energy malnutrition in Nigerian children in Savanna belt. (6429350)
1984
44
Folate levels and deoxyuridine suppression tests in protein-energy malnutrition. (6401209)
1983
45
Clinical significance of serum transcobalamins in protein-energy malnutrition. (16829416)
1983
46
Serum phosphorus in protein energy malnutrition. (6821115)
1982
47
Plasma alpha-tocopherol (vitamin E) levels and tocopherol-lipid ratio among children with protein-energy malnutrition (PEM). (6185084)
1982
48
High-density-lipoprotein-cholesterol in protein-energy malnutrition. (6805501)
1982
49
Transcobalamin II in protein-energy malnutrition among residents of the Kivu area. (7139939)
1982
50
Outcome of children with severe grades of protein energy malnutrition in an I.C.D.S. block. (6797942)
1981

Variations for Protein-Energy Malnutrition

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Expression for genes affiliated with Protein-Energy Malnutrition

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Protein-Energy Malnutrition

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Pathways for genes affiliated with Protein-Energy Malnutrition

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51PathCards, 56Reactome, 54QIAGEN, 39NCBI BioSystems Database
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Compounds for genes affiliated with Protein-Energy Malnutrition

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46Novoseek, 25HMDB, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 30IUPHAR
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Compounds related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1styrene469.8RBP4, EPHX1
2purpurin469.8RBP4, TTR
3retinyl palmitate46 2510.7TTR, RBP4
4lutein469.7RBP4, TTR
5tocopherol469.7TTR, RBP4
6cellulose acetate469.7RBP4, TTR
7mspi469.7EPHX1, TTR
8phosphorus469.7RBP4, TTR
9isoleucine469.7RBP4, TTR
10betacarotene469.7RBP4, TTR
11triiodothyronine469.7RBP4, TTR
12uric acid46 2510.6RBP4, TTR
13vitamin-e469.6TTR, RBP4
14alpha tocopherol469.6TTR, RBP4
15resveratrol46 62 25 1212.6TTR, EPHX1
16urea46 25 1211.5RBP4, TTR
17amide469.5CCK, EPHX1
18thyroxine46 2510.4RBP4, TTR
19sulfate46 2510.4EPHX1, CCK
20valine469.3RBP4, TTR
21vitamin a46 25 1211.3PIGR, TTR, RBP4
22leucine469.2PIGR, TTR, RBP4
23carbohydrates469.2CCK, TTR
24alanine469.1RBP4, TTR, PIGR
25pyruvate469.1TTR, PIGR
26aspirin46 52 30 2512.0CCK, TTR
27estrogen469.0TTR, EPHX1, RBP4
28glycerol46 25 1210.9TTR, CCK
29folate468.9TTR, CCK, RBP4
30dopamine46 30 25 1211.9TTR, CCK, RBP4
31adenylate468.9RBP4, CCK, TTR
32testosterone46 62 25 1211.8TTR, CCK, RBP4
33dexamethasone46 52 30 1211.8TTR, CCK, RBP4
34arginine468.8CCK, EPHX1, TTR
35glucose468.6TTR, CCK, RBP4
36retinoic acid46 259.5RBP4, CCK, TTR, PIGR
37cholesterol46 30 25 1211.4RBP4, CCK, EPHX1, TTR

GO Terms for genes affiliated with Protein-Energy Malnutrition

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17Gene Ontology
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Cellular components related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1RBP4, CCK, TTR, PIGR

Biological processes related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phototransduction, visible lightGO:0076039.3RBP4, TTR
2retinol metabolic processGO:0425729.2RBP4, TTR
3retinoid metabolic processGO:0015239.0RBP4, TTR

Molecular functions related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.0CCK, TTR

Products for genes affiliated with Protein-Energy Malnutrition

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Sources for Protein-Energy Malnutrition

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet