PEM
MCID: PRT038
MIFTS: 44

Protein-Energy Malnutrition (PEM) malady

Metabolic category

Summaries for Protein-Energy Malnutrition

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Protein–energy malnutrition (or protein–calorie malnutrition) refers to a form of malnutrition where... more...

MalaCards: Protein-Energy Malnutrition, also known as PEM, is related to marasmus and arthritis. An important gene associated with Protein-Energy Malnutrition is PIGR (polymeric immunoglobulin receptor), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Platelet degranulation . The compounds uric acid and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Protein-Energy Malnutrition

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 39NCBI Bookshelf, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Metabolic


Aliases & Descriptions:

protein-energy malnutrition 8 10 45 61
pem 39


External Ids:

Disease Ontology8 DOID:11801
ICD9CM27 263.9
NCIt40 C34952
MeSH35 D011502
ICD1025 E46

Related Diseases for Protein-Energy Malnutrition

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Protein-Energy Malnutrition via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1marasmus30.7ALB, TF, LSL
2arthritis30.6ALB, LEP, IL1RAPL2, HP, CSN1S1
3lactose intolerance30.5CSN1S1
4protein-losing enteropathy30.5ALB, TF
5hepatitis c30.5GSR, GGT1, HP, TF, LSL
6cystic fibrosis30.5ALB, SI, HP, EPHX1, ANXA6, RBP4
7tuberculosis30.5GSR, ALB, IL1RAPL2, HP, LSL, H6PD
8insulin resistance30.5ALB, GGT1, TTR, LEP, IGF1, IGFBP1
9viral hepatitis30.3GGT1
10iron deficiency anemia30.3TF
11fetal macrosomia30.3LEP
12hyperinsulinism30.3LEP, IGF1, IGFBP1, LSL
13alcoholic liver cirrhosis30.3ALB, GGT1, TF, LSL
14anorexia nervosa30.3TTR, LEP, IGF1, IGFBP1, LSL, CCK
15deficiency anemia30.3GSR, ALB, TTR, HP, TF, LSL
16kwashiorkor10.6
17protein c deficiency10.6
18measles10.4
19hepatitis e10.3
20biotin deficiency10.3
21protein s deficiency10.3
22cerebral malaria10.3
23acute leukemia10.3
24hepatitis a10.3
25protein r deficiency10.3
26protein-deficiency anemia10.2
27acute diarrhea10.2
28visceral leishmaniasis10.2
29giardiasis10.2
30ariboflavinosis10.2
31juvenile rheumatoid arthritis10.2
32hepatitis d10.2
33paracoccidioidomycosis10.2
34adult syndrome10.2
35alcoholic hepatitis10.2
36tetanus10.2
37wilms tumor10.2
38tuberculous meningitis10.2
39brain injury10.2
40cerebral atrophy10.2
41dysphagia10.2
42pancreatitis, chronic10.2
43homocysteine plasma level10.2
44riboflavin deficiency10.2
45blindness10.2
46brain ischemia10.2
47vaginitis10.1
48peritonitis10.0ALB
49crohn's disease10.0ALB
50pulmonary disease, chronic obstructive10.0EPHX1

Graphical network of the top 20 diseases related to Protein-Energy Malnutrition:



Diseases related to protein-energy malnutrition

Clinical Features for Protein-Energy Malnutrition

Drugs & Therapeutics for Protein-Energy Malnutrition

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Protein-Energy Malnutrition

Drug clinical trials:

Search ClinicalTrials for Protein-Energy Malnutrition

Search NIH Clinical Center for Protein-Energy Malnutrition

Search CenterWatch for Protein-Energy Malnutrition

Genetic Tests for Protein-Energy Malnutrition

Anatomical Context for Protein-Energy Malnutrition

Animal Models for Protein-Energy Malnutrition or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Protein-Energy Malnutrition:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0H6PD, CCK, RBP4
2MP:00053768.3H6PD, CCK, TF, PIGR, RBP4, IGF1

Publications for Protein-Energy Malnutrition

Sources:
51PubMed
See all sources

Articles related to Protein-Energy Malnutrition:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Relation of oxidative stress, zinc and alkaline phosphatase in protein energy malnutrition. (23373727)
2013
2
Rutin (quercetin rutinoside) induced protein-energy malnutrition in chronic kidney disease, but quercetin acted beneficially. (23876017)
2013
3
The effect of serum magnesium levels and serum endothelin-1 levels on bone mineral density in protein energy malnutrition. (23155975)
2012
4
Protein-energy malnutrition in hospitalized patients: early assessment for better outcome. (22953619)
2012
5
Plasma homocysteine levels in cardiovascular disease, malaria and protein-energy malnutrition in Sudan. (20218135)
2009
6
Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates. (19448901)
2009
7
Effects of Cholerella sp. microalgae extract on colonic anastomosis in rats with protein-energy malnutrition. (18070156)
2008
8
Structural and functional affection of the heart in protein energy malnutrition patients on admission and after nutritional recovery. (16319835)
2006
9
Pancreatic size in protein energy malnutrition: a predictor of nutritional recovery. (15536474)
2005
10
Serum leptin concentrations in children with mild protein-energy malnutrition and catch-up growth. (15491379)
2004
11
Prevalence of protein-energy malnutrition at diagnosis in children with acute lymphoblastic leukemia. (10435658)
1999
12
Serum magnesium levels in protein-energy malnutrition. (9604603)
1998
13
Biotin deficiency in protein-energy malnutrition: implications for nutritional homeostasis and individuality. (9433719)
1997
14
Inflammatory mediators in children with protein-energy malnutrition. (9129488)
1997
15
Protein-energy malnutrition: the nature and extent of the problem. (16844615)
1997
16
The CD4/CD8 ratio in the blood does not reflect the response of this index in secondary lymphoid organs of weanling mice in models of protein-energy malnutrition known to depress thymus-dependent immunity. (8613887)
1996
17
Patterns of muscle and fat mass repair during recovery from advanced infantile protein-energy malnutrition. (8793421)
1996
18
Bone marrow and chelatable iron in patients with protein energy malnutrition. (8980561)
1996
19
The clinical assessment of adult patients with protein energy malnutrition. (7659057)
1995
20
Protein energy malnutrition in the Bloemfontein area. (8553157)
1995
21
The prognostic significance of protein-energy malnutrition in geriatric patients. (7645437)
1995
22
Biotin supplementation affects lymphocyte carboxylases and plasma biotin in severe protein-energy malnutrition. (7840079)
1995
23
Antimicrobial effects of granulocyte-macrophage colony-stimulating factor in protein-energy malnutrition. (7492274)
1995
24
Computerized cry analysis in infants affected by severe protein energy malnutrition. (8193504)
1994
25
Protein-energy malnutrition in cystic fibrosis patients. (8025359)
1994
26
Management of protein-energy malnutrition in Nigeria: an evaluation of the regimen at the Kersey Nutrition Rehabilitation Centre, Nigeria. (7992350)
1994
27
Protein energy malnutrition--results of rehabilitation. (7839207)
1994
28
Correlation of some biochemical parameters with clinical features of protein energy malnutrition. (7925048)
1994
29
Zinc supplementation in protein energy malnutrition. (8132259)
1993
30
Rat models of protein and protein-energy malnutrition. (8320060)
1993
31
Protein energy malnutrition and the nervous system. (1506874)
1992
32
Effect of caloreen supplementation on some haematological values and urinary iron excretion during protein-energy malnutrition. (1600935)
1992
33
Relationship of insulin resistance to protein-energy malnutrition in patients with alcoholic liver cirrhosis: effect of short-term nutritional support. (1443438)
1992
34
Infections in children with severe protein-energy malnutrition. (1448316)
1992
35
Comparative study of glycosylated haemoglobin and serum fructosamine values in children with protein-energy malnutrition. (1790555)
1991
36
Hookworm infection and protein-energy malnutrition: transverse evidence from two Malaysian ecological groups. (2124397)
1990
37
Oral plasma zinc tolerance test in patients with protein energy malnutrition. (2513780)
1989
38
Liver function in protein-energy malnutrition measured by cinnamic acid tolerance and benzoic acid tolerance: effect of carnitine supplementation. (2706226)
1989
39
Value of serum transthyretin measurements in the assessment of marginal protein-energy malnutrition in rats. (2457071)
1988
40
Small bowel function in mild to moderate protein-energy malnutrition. (3100443)
1986
41
Serum insulin-like growth factors I and II concentrations and growth hormone and insulin responses to arginine infusion in children with protein-energy malnutrition before and after nutritional rehabilitation. (3099250)
1986
42
Functional anemia of complicated protein-energy malnutrition at high altitude. (3088972)
1986
43
In vitro study of phagocytic and bactericidal activity of neutrophils in cases of protein energy malnutrition. (3938974)
1985
44
Decreased levels of alpha 2 HS-glycoprotein in children with protein-energy-malnutrition. (3935449)
1985
45
Erythrocyte membrane in protein-energy malnutrition: A23187-induced changes in osmotic fragility of human and rat erythrocytes. (6433903)
1984
46
Protein-energy malnutrition: an integral approach and a simple new classification. (6440876)
1984
47
Epiphyseal and non-epiphyseal anomalies of hand in protein energy malnutrition. (6413406)
1983
48
The utility of cross-sectional measurements of weight and length for age in screening for growth failure (chronic malnutrition) and clinically severe protein-energy malnutrition. (6424402)
1983
49
Erythrocyte glycolysis in protein-energy malnutrition. (6290107)
1982
50
Chronic diarrhoea in protein-energy malnutrition. (6804920)
1981

Genetic Variations for Protein-Energy Malnutrition

Expression for genes affiliated with Protein-Energy Malnutrition

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Protein-Energy Malnutrition

Search GEO for disease gene expression data for Protein-Energy Malnutrition.

Pathways for genes affiliated with Protein-Energy Malnutrition

Sources:
38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ALB, TTR, IGFBP1
2
Hide members
10.0TF, IGF1, ALB
310.0LEP, IGFBP1, TF
49.9GSR, ALB, GGT1

Compounds for genes affiliated with Protein-Energy Malnutrition

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1uric acid45 2411.8TTR
2estrogen4510.6SI, TTR
3alpha tocopherol4510.5RBP4, TTR, TF
4vitamin a45 11 2412.1CSN1S1, PIGR, HP, RBP4, IGFBP1
5dehydroepiandrosterone sulfate4510.1RBP4, LSL, IGFBP1
6glutamate4510.1PC, IL1RAPL2, ANXA6, CCK
7tocopherol4510.0TTR, HP, GSR, TF, RBP4
8rosiglitazone45 50 29 11 2414.0IGFBP1, LSL, RBP4, LEP
9norepinephrine45 11 2412.0IL1RAPL2, CCK, TTR
10beta-hydroxybutyrate4510.0LEP, IGFBP1, LSL, PC, HP
11cellulose acetate459.9HP, RBP4, ALB, TTR, IL1RAPL2
12glutaraldehyde459.9H6PD, TF, CSN1S1, TTR, ALB
13prednisolone45 29 1111.8IGFBP1, LSL, CSN1S1, IL1RAPL2
14betacarotene459.8RBP4, TF, TTR, GGT1, GSR, LEP
15starch459.8SI, HP, IGF1, TF, CSN1S1, H6PD
16dexamethasone45 50 29 1112.7RBP4, PC, GGT1, SI, IL1RAPL2, CCK
17triiodothyronine459.7LEP, SI, LSL, RBP4, IGFBP1, IGF1
18aspartate459.7RBP4, CSN1S1, LSL, TTR, SI, ALB
19fatty acid459.7RBP4, H6PD, LSL, PC, IGFBP1, SI
20vitamin b12459.6CSN1S1, ALB, IGF1, HP, TTR, GGT1
21polysaccharide459.6CCK, CSN1S1, HP, SI
22polyethylene glycol459.6IL1RAPL2, IGFBP1, TF, HP, ALB, CSN1S1
23malondialdehyde459.6SI, GGT1, LSL, H6PD, GSR, HP
24glycerol45 11 2411.6CCK, CSN1S1, IGFBP1, PC, LSL, LEP
25tamoxifen45 50 29 1112.6EPHX1, IGF1, IGFBP1, LSL, GGT1
26valproate459.6LSL, IGFBP1, IGF1, GGT1, GSR
27heparin45 29 11 2412.5CSN1S1, HP, IL1RAPL2
28acth459.5CCK, LSL, LEP, IGFBP1, HP, IL1RAPL2
29polyacrylamide459.5SI, HP, PC, RBP4, CSN1S1, H6PD
30glucose459.5H6PD, SI, IL1RAPL2, PC, IGF1, RBP4
31folate459.4HP, TTR, RBP4, TF, CSN1S1, CCK
32carbohydrates459.4IGFBP1, SI, LEP, TTR, HP, TF
33epinephrine45 11 2411.3LSL, TF, PIGR, IL1RAPL2, IGFBP1, HP
34h2o2459.3SI, H6PD, CSN1S1, ANXA6, IL1RAPL2, LEP
35methotrexate45 50 1111.3SI, LSL, IL1RAPL2, LEP, TF, ALB
36urea45 11 2411.3ALB, H6PD, CSN1S1, GGT1, TTR, HP
37fibrinogen459.3TTR, ALB, LEP, IL1RAPL2, LSL, CSN1S1
38iron45 2410.2GGT1, TTR, IL1RAPL2, HP, RBP4, TF
39glutamine459.2PC, H6PD, CCK, CSN1S1, TF, TTR
40ascorbic acid45 2410.2LEP, HP, RBP4, TF, CSN1S1, H6PD
41steroid459.1LSL, RBP4, LEP, IL1RAPL2, HP, IGFBP1
42cysteine459.0RBP4, CSN1S1, H6PD, HP, SI, LEP
43arginine458.9CSN1S1, IGFBP1, EPHX1, CCK, LSL, GSR
44thyroxine45 249.8TF, IGF1, HP, LEP, TTR, GGT1
45alanine458.8GSR, HP, PC, RBP4, PIGR, TF
46testosterone45 60 11 2411.6IGFBP1, GGT1, TTR, LEP, IL1RAPL2, HP
47lipid458.6ALB, GSR, GGT1, LEP, SI, HP
48creatinine458.4CSN1S1, LSL, H6PD, TF, RBP4, IGFBP1
49lactate458.4HP, IL1RAPL2, SI, H6PD, LSL, CSN1S1
50cholesterol45 29 11 2410.9TF, LSL, CCK, H6PD, CSN1S1, TTR

GO Terms for genes affiliated with Protein-Energy Malnutrition

Sources:
16Gene Ontology
See all sources

Cellular components related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.3RBP4, IGFBP1, IGF1, HP, LEP, TTR
2extracellular regionGO:0055768.5ALB, CCK, CSN1S1, TF, PIGR, RBP4

Biological processes related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bone mineralization involved in bone maturationGO:03563010.0LEP, IGF1
2platelet degranulationGO:00257610.0ALB, IGF1, TF
3negative regulation of appetiteGO:0320999.9LEP, CCK

Molecular functions related to Protein-Energy Malnutrition according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.9TTR, LEP, IGF1, CCK

Products for genes affiliated with Protein-Energy Malnutrition

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Sources for Protein-Energy Malnutrition

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet