MCID: PRT019
MIFTS: 48

Protein-Losing Enteropathy malady

Gastrointestinal diseases category

Summaries for Protein-Losing Enteropathy

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Protein losing enteropathy refers to any condition of the gastrointestinal tract that results in a net... more...

MalaCards: Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to lupus erythematosus and gastroenteritis. An important gene associated with Protein-Losing Enteropathy is MPI (mannose phosphate isomerase), and among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Selected targets of C/EBPalpha. The compounds captopril and oxyphenbutazone have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and liver.

Description from OMIM:46 226300

Aliases & Classifications for Protein-Losing Enteropathy

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 46OMIM, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

protein-losing enteropathy 8 10
protein-losing enteropathies 44 60
enteropathy, exudative 8
exudative enteropathy 8


External Ids:

Disease Ontology8 DOID:10611
OMIM46 226300
SNOMED-CT56 66972006, 22542007
MeSH34 D011504

Related Diseases for Protein-Losing Enteropathy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Protein-Losing Enteropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus31.4CD79A
2gastroenteritis31.0CD79A
3amyloidosis30.9ALB, NPPB, CD79A
4hepatitis30.8TF, ALB, SERPINA1
5connective tissue disease30.8CD79A, ALB
6arthritis30.7ALB
7ulcerative colitis30.7ALB
8rheumatoid arthritis30.7SERPINA1, CD79A, OXA1L
9gastritis30.5CD79A
10peritonitis30.5ALB, MUC16
11congenital disorder of glycosylation30.5MPI, ALG6
12bronchitis30.5SERPINA1, CD79A
13protein-energy malnutrition30.5ALB, TF
14pancreatitis30.4ALB, IGES, SERPINA1
15pneumonia30.4CD79A, OXA1L, SERPINA1, IGES
16liver cirrhosis30.4TF, SERPINA1, ALB
17deficiency anemia30.4TF, MUC16, ALB, CD79A
18acquired immunodeficiency syndrome30.2ALB
19thyroiditis30.2CD79A
20vascular disease30.2TF
21eosinophilia30.2CD79A, IGES
22vasculitis30.2CD79A, SERPINA1, ALB
23ankylosing spondylitis30.2CD79A, SERPINA1
24adenocarcinoma30.2OXA1L, MUC16, SERPINA1
25systemic lupus erythematosus11.0
26eosinophilic gastroenteritis10.7
27constrictive pericarditis10.7
28pericarditis10.7
29diarrhea10.6
30purpura10.5
31crohn's disease10.5
32cronkhite-canada syndrome10.5
33hepatitis a10.5
34dermatitis10.5
35hypertension10.5
36congenital hepatic fibrosis10.5
37mixed connective tissue disease10.4
38portal hypertension10.4
39giardiasis10.4
40measles10.4
41kaposi's sarcoma10.4
42food allergy10.4
43histiocytosis10.4
44intestinal disease10.4
45langerhans-cell histiocytosis10.4
46lymphedema10.4
47neuroblastoma10.4
48sarcoidosis10.4
49sarcoma10.4
50graft versus host disease10.3

Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to protein-losing enteropathy

Clinical Features for Protein-Losing Enteropathy

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

226300

Drugs & Therapeutics for Protein-Losing Enteropathy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Protein-Losing Enteropathy

Drug clinical trials:

Search ClinicalTrials for Protein-Losing Enteropathy

Search NIH Clinical Center for Protein-Losing Enteropathy

Search CenterWatch for Protein-Losing Enteropathy

Genetic Tests for Protein-Losing Enteropathy

About this section

Anatomical Context for Protein-Losing Enteropathy

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Protein-Losing Enteropathy:

32
Heart, Small intestine, Liver, Colon, Testes, Bone, Skin, B cells, T cells, Breast, Thyroid, Bone marrow, Lung, Lymph node

Animal Models for Protein-Losing Enteropathy or affiliated genes

About this section

Publications for Protein-Losing Enteropathy

About this section
Sources:
50PubMed
See all sources

Articles related to Protein-Losing Enteropathy:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Haemodynamic characteristics before and after the onset of protein losing enteropathy in patients after the Fontan operation. (23396878)
2013
2
Painless ascites and elevated CA125: initial presentation of lupus-associated protein-losing enteropathy. (23886639)
2013
3
Recovery of graft steatosis and protein-losing enteropathy after biliary diversion in a PFIC 1 liver transplanted child. (21672103)
2012
4
In-111 transferrin scintigraphy in cirrhosis with hypoalbuminemia: evidence for protein-losing enteropathy in a small group of selected cases. (22989334)
2012
5
Giardia infection: protein-losing enteropathy in an adult with immunodeficiency. (22654437)
2012
6
Protein-losing enteropathy with mesenteric venous thrombosis: a forme fruste of systemic lupus erythematosus. (19812125)
2009
7
Chronic edema from protein-losing enteropathy: scintigraphic diagnosis. (19404299)
2009
8
Protein-losing enteropathy during highly active antiretroviral therapy in a patient with AIDS-related disseminated Mycobacterial avium complex infection. (19688246)
2009
9
Clinical presentation and endoscopic features of primary gastric Burkitt lymphoma in childhood, presenting as a protein-losing enteropathy: a case report. (19830151)
2009
10
Late-onset Lymphedema and Protein-losing Enteropathy with Noonan Syndrome. (23926366)
2009
11
Protein-losing enteropathy after the Fontan operation: associations and predictors of clinical outcome. (18715460)
2008
12
Using heparin therapy to reverse protein-losing enteropathy in a patient with CDG-Ib. (18285818)
2008
13
Outcome of surgical resection for protein-losing enteropathy in systemic lupus erythematosus. (18500433)
2008
14
Lymphatic obstruction and protein-losing enteropathy in patients with congenital heart disease. (18715461)
2008
15
Aggressive systemic mastocytosis complicated by protein-losing enteropathy. (16843741)
2007
16
Stents in the successful management of protein-losing enteropathy after fontan. (17906348)
2007
17
A case of rheumatoid arthritis with protein losing enteropathy induced by multiple diaphragmatic strictures of the small intestine: successful treatment by bougieing under double-balloon enteroscopy. (16905713)
2006
18
Crohn's disease diagnosed by wireless capsule endoscopy in adolescents with abdominal pain, protein-losing enteropathy, anemia and negative endoscopic and radiologic findings. (15847199)
2005
19
Protein-losing enteropathy as the principal manifestation of constrictive pericarditis. (16191147)
2005
20
Successful treatment of protein-losing enteropathy induced by intestinal lymphangiectasia in a liver cirrhosis patient with octreotide: a case report. (15201518)
2004
21
A systemic lupus erythematosus patient with protein losing enteropathy. (15515205)
2004
22
Protein-losing enteropathy caused by Lawsonia intracellularis in a weanling foal. (12619560)
2003
23
Protein-losing enteropathy detected on Tc-99m HSA and Tc-99m MDP scintigraphy. (12045436)
2002
24
Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology. (11958575)
2002
25
Protein-losing enteropathy: diagnosis with (99m)Tc-labeled human serum albumin scintigraphy. (11274540)
2001
26
Perioperative risk factors for development of protein-losing enteropathy following a Fontan procedure. (11703976)
2001
27
99mTc-human serum albumin scans in children with protein-losing enteropathy. (10688102)
2000
28
Small intestinal adenomatous polyposis resulting in protein-losing enteropathy in a horse. (10643985)
2000
29
Peutz-Jeghers syndrome associated with adenocarcinoma and protein-losing enteropathy. (11023591)
2000
30
Protein-losing enteropathy secondary to hepatic venous outflow obstruction after liver transplantation. (9252097)
1997
31
Effect of percutaneous fenestration of the atrial septum on protein-losing enteropathy after the Fontan operation. (8774342)
1996
32
Primary lupus-associated protein-losing enteropathy. (8048795)
1994
33
Simvastatin-induced protein-losing enteropathy. (1734709)
1992
34
Cellular immunodeficiency in protein-losing enteropathy. Predominant reduction of CD3+ and CD4+ lymphocytes. (1670632)
1991
35
Protein-losing enteropathy in congestive cardiac failure: an entity of minor clinical significance. (2301337)
1990
36
Helicobacter pylori and protein losing enteropathy. (2334217)
1990
37
Protein-losing enteropathy in an infant with a lymphangiomyoma. (2614629)
1989
38
Protein-losing enteropathy associated with Clostridium perfringens infection. (2569066)
1989
39
Protein-losing enteropathy in systemic lupus erythematosus. Observations by magnifying endoscopy. (2689113)
1989
40
Protein losing enteropathy in the different forms of protein-energy malnutrition. (3123710)
1987
41
Protein-losing enteropathy in systemic lupus erythematosus. (7152512)
1982
42
Congenital hepatic fibrosis combined with protein-losing enteropathy and recurrent thrombosis. (7446108)
1980
43
Clinicopathologic consideration of protein-losing enteropathy due to lymphangiectasia of the intestine. (7404312)
1980
44
Protein-losing enteropathy and intestinal lymphangiectasia after superior vena cava--right pulmonary artery (Glenn) shunt. (312364)
1979
45
Protein losing enteropathy and villus lymphangiectasia in constrictive pericarditis with ring constriction of inferior vena cava. (5280737)
1971
46
Protein-losing enteropathy in the graft-versus-host reaction. (4392380)
1970
47
Growth hormone in protein-losing enteropathy. (4177228)
1968
48
Use of 51-CrCl-3 in the diagnosis of protein-losing enteropathy. (6022343)
1967
49
Protein-losing enteropathy. (5324268)
1966
50
Roentgenologic changes in protein-losing enteropathy. (5929121)
1966

Genetic Variations for Protein-Losing Enteropathy

About this section

Expression for genes affiliated with Protein-Losing Enteropathy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Protein-Losing Enteropathy

Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for genes affiliated with Protein-Losing Enteropathy

About this section
Sources:
53Reactome, 12EMD Millipore
See all sources

Pathways related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8ALG6, MPI
29.7ALB, TF
3
Hide members
9.2ALB, SERPINA1, TF

Compounds for genes affiliated with Protein-Losing Enteropathy

About this section
Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB
See all sources

Compounds related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1captopril44 28 49 59 1114.4CD79A
2oxyphenbutazone44 1111.1OXA1L
3Bismuth Subsalicylate1110.0TF, ALB
4kp-10194410.0TF, ALB
5dansylsarcosine4410.0OXA1L, ALB
6rhsa449.9OXA1L, ALB
7tolmetin glucuronide449.9ALB, OXA1L
8azapropazone44 1110.9OXA1L, ALB
9pirprofen449.9OXA1L, ALB
10cellulose acetate449.9MPI, CD79A, ALB
11kebuzone449.9OXA1L, ALB
12sodium octanoate449.9OXA1L, ALB
13acetyldigitoxin44 1110.9OXA1L, ALB
14hhpa449.9ALB, OXA1L
15eprex449.8ALB, OXA1L
16dansylamide44 1110.8ALB, OXA1L
17ramipril44 1110.8CD79A, NPPB, ALB
18sulfisoxazole44 59 49 1112.8OXA1L, ALB
19(s)-ketoprofen449.8ALB, OXA1L
20polyvinylpyrrolidone449.8ALB, OXA1L
21fenoprofen28 44 1111.7ALB, OXA1L
22cyclosarin449.7ALB, OXA1L
23sinapic acid449.7OXA1L, TF
24piroxicam44 1110.6OXA1L, CD79A, ALB
25warfarin44 49 11 2412.6CD79A, OXA1L
26enterotoxin449.6CD79A, NPPB, IGES
27indoxyl sulfate449.6OXA1L, ALB
28phenylbutazone44 1110.5ALB, SERPINA1, OXA1L
29furosemide44 49 59 28 11 2414.5OXA1L, NPPB, ALB
30suprofen44 1110.5OXA1L, ALB, TF
31phenytoin44 49 28 1112.4OXA1L, CD79A, ALB
32dtpa449.4ALB, TF, OXA1L
33tacrolimus44 49 1111.2NPPB, TF, CD79A, ALB
34vitamin b12449.2TF, ALB, CD79A
35palmitate449.1DGAT1, TF, OXA1L, ALB
36glutaraldehyde449.1ALB, TF, OXA1L, CD79A
37polyethylene glycol449.1ALB, CD79A, OXA1L, TF
38indomethacin44 59 28 1112.1DGAT1, NPPB, CD79A, ALB
39ascorbic acid44 249.9ALB, SERPINA1, CD79A, TF
40aspirin44 49 28 2411.9NPPB, IGES, OXA1L, CD79A
41bicarbonate448.9ALB, MUC16, TF, NPPB
42salicylic acid44 289.8OXA1L, SERPINA1, ALB
43histamine44 28 2410.8ALB, CD79A, IGES, TF, NPPB
44thyroxine44 249.7CD79A, ALB, OXA1L, TF, NPPB
45iron44 249.7MUC16, SERPINA1, NPPB, TF
46prednisolone44 28 1110.5TF, MUC16, CD79A, ALB, NPPB
47glucose448.2ALB, SERPINA1, NPPB, MUC16, DGAT1, MPI
48creatinine448.0TF, MUC16, NPPB, CD79A, SERPINA1, ALB
49lactate448.0CD79A, ALB, TF, IGES, NPPB, MUC16
50fibrinogen447.8CD79A, MUC16, OXA1L, TF, SERPINA1, ALB

GO Terms for genes affiliated with Protein-Losing Enteropathy

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dolichol-linked oligosaccharide biosynthetic processGO:0064889.8MPI, ALG6
2platelet degranulationGO:0025769.2ALB, SERPINA1, TF
3post-translational protein modificationGO:0436878.9MUC16, ALG6, MPI
4platelet activationGO:0301688.9SERPINA1, TF, ALB

Products for genes affiliated with Protein-Losing Enteropathy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Protein-Losing Enteropathy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet