Protein-losing Enteropathy malady

Wikipedia: Protein losing enteropathy refers to any condition of the gastrointestinal tract that results in a net...⁴⁴ more...

MalaCards: Protein-losing Enteropathy, also known as protein-losing enteropathies, is related to eosinophilic gastroenteritis and congenital disorder of glycosylation. An important gene associated with Protein-losing Enteropathy is MPI (mannose phosphate isomerase), and among its related pathways is Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. The compounds azapropazone and sodium octanoate have been mentioned in the context of this disorder. Affiliated tissues include heart.

Aliases & Descriptions:

protein-losing enteropathy 6 8 protein-losing enteropathies 32 43 protein-losing enteropathy (disorder) 6

exudative enteropathy (disorder) 6 enteropathy, exudative 6 intestinal diseases 43

Diseases related to protein-losing enteropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 201)

id	Related Disease	Score	Top Affiliating Genes
1	eosinophilic gastroenteritis	32.0	IGES, ALB
2	congenital disorder of glycosylation	31.7	MPI, ALG6
3	gastroenteritis	31.1	ALB, IGES, CD79A
4	connective tissue disease	30.8	CD79A, MUC16, ALB
5	constrictive pericarditis	30.0	ALB, NPPB
6	hepatitis	29.7	SERPINA1, TF, ALB
7	histiocytosis	29.6	SERPINA1, ALB, TF
8	protein-energy malnutrition	29.6	ALB, CD79A, TF
9	systemic lupus erythematosus	29.3	NPPB, ALB, TF, OXA1L, MUC16, CD79A
10	lupus erythematosus	29.3	TF, MUC16, CD79A, OXA1L, ALB, NPPB
11	congestive heart failure	29.1	MUC16, NPPB, ALB
12	bronchitis	28.8	TF, ALB, SERPINA1, CD79A
13	amyloidosis	28.3	TF, NPPB, ALB, CD79A
14	anemia	27.2	MUC16, OXA1L, TF, NPPB, CD79A, ALB
15	cerebritis	27.0	CD79A, TF, NPPB, SERPINA1, ALB, OXA1L
16	cholesterol	26.9	NPPB, OXA1L, TF, ALB, SERPINA1, CD79A
17	pancreatitis	26.9	MUC16, CD79A, ALB, OXA1L, IGES, TF
18	short bowel syndrome	26.7	CD79A, ALB, IGES
19	fibrosis	26.2	ALB, SERPINA1, TF, OXA1L, IGES, MPI
20	dysalbuminemic hyperthyroxinemia	13.4	ALB, OXA1L
21	immune-complex glomerulonephritis	13.3	ALB, OXA1L
22	miliary tuberculosis	13.2	ALB, MUC16
23	hepatic tuberculosis	13.2	ALB, SERPINA1
24	yellow nail syndrome	13.2	ALB, TF
25	lipoid nephrosis	13.2	ALB, TF
26	nutritional deficiency disease	13.2	TF, ALB
27	marasmus	13.2	ALB, TF
28	pericardial effusion	13.2	ALB, MUC16
29	berger disease	13.1	ALB, CD79A
30	chronic pyelonephritis	13.0	CD79A, ALB
31	calciphylaxis	13.0	ALB, CD79A
32	strongyloidiasis	13.0	CD79A, ALB
33	lymphatic system disease	13.0	ALB, CD79A
34	hyper-ige syndrome	13.0	IGES, CD79A
35	dysphagia	13.0	TF, ALB
36	chronic rapidly progressive glomerulonephritis	13.0	CD79A, ALB
37	congenital disorder of glycosylation type i	13.0	SERPINA1, TF
38	pandas	13.0	ALB, IGES, OXA1L
39	acute poststreptococcal glomerulonephritis	13.0	CD79A, ALB
40	extrinsic allergic alveolitis	13.0	ALB, CD79A
41	steroid-resistant nephrotic syndrome	12.9	ALB, TF
42	opiate dependence	12.9	ALB, TF
43	membranous glomerulonephritis	12.9	ALB, CD79A
44	focal segmental glomerulosclerosis	12.9	CD79A, ALB
45	myxedema	12.9	MUC16, CD79A
46	siderosis	12.9	SERPINA1, TF
47	alcoholic liver cirrhosis	12.9	ALB, TF
48	short limb dwarf edema iris coloboma	12.8	ALB, NPPB
49	autoimmune disease of central nervous system	12.8	CD79A, TF
50	hepatic fibrosis renal cysts mental retardation	12.8	ALB, TF, OXA1L

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to protein-losing enteropathy:

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Articles related to protein-losing enteropathy:

(show all 34)

id	Title	Authors	Year	Affiliating Genes
1	Pitfalls of technetium-99m-labeled human serum albumi n scintigraphy for protein-losing enteropathy. (19789543)	Hsu Y.J.... Jaiteh L.E.	2009	ALB
2	Medium-term management of protein-losing enteropathy of cardiac origin unresponsive to medical therapy in a patient awaiting heart transplantation (19371966)	Melero J.L.... Ponce J.	2009	ALB
3	Serum cholesterol in idiopathic and lupus-related protein-losing enteropathy. (18539712)	Kim Y.G.... Yoo B.	2008	ALB
4	Resolution of protein-losing enteropathy with low-molecular weight heparin in an adult patient with Fontan palliation. (18036954)	Bhagirath K.M.... Tam J.W.	2007	ALB
5	Protein-losing enteropathy after fontan operation: investigations into possible pathophysiologic mechanisms. (16863787)	Ostrow A.M.... Rychik J.	2006	NPPB
6	Protein-losing enteropathy after the Fontan operation : clinical analysis of nine cases. (17214396)	Lin W.S.... Su W.J.	2006	ALB
7	Protein-losing enteropathy in Crohn's disease. (17343081)	Ferrante M.... Van Assche G.	2006	ALB
8	Application of technetium-99m-labeled human serum albumin scan to assist surgical treatment of protein-losing enteropathy in Cronkhite-Canada syndrome: report of a case. (15768184)	Tseng K.C.... Dai Y.C.	2005	ALB
9	Severe protein losing enteropathy with intractable di arrhea due to systemic AA amyloidosis, successfully treated with corticosteroid and octreotide. (16076611)	Fushimi T.... Ikeda S.	2005	ALB
10	Reversal of protein-losing enteropathy with calcium replacement in a patient after Fontan operation. (15063295)	Kim S.J.... Shim W.S.	2004	ALB
11	Protein losing enteropathy (PLE) detected by Tc99m-labelled human serum albumin abdominal scintigraphy--case report (15065343)	Hubalewska-HoA8a A.... SzybiA8ski Z.	2003	ALB
12	Oral disodium cromoglycate and ketotifen for a patient with eosinophilic gastroenteritis, food allergy and protein-losing enteropathy. (15032404)	Suzuki J.... Suzuki H.	2003	ALB
13	Protein losing enteropathy-hepatic fibrosis syndrome in Saguenay-Lac St-Jean, Quebec is a congenital disorder of glycosylation type Ib. (12414827)	Vuillaumier-Barrot S.... Seta N.	2002	MPI
14	Plastic bronchitis in children with Fontan palliation : analogue to protein losing enteropathy? (11924535)	Stiller B.... van Landeghem F.K.	2002	ALB
15	Protein-losing enteropathy: diagnosis with (99m)Tc-labeled human serum albumin scintigraphy. (11274540)	Chiu N.T.... Yu H.S.	2001	ALB, OXA1L
16	Protein-losing enteropathy exacerbated with the appearance of symptoms of systemic lupus erythematosus. (11393422)	Yoshida M.... Kasukawa R.	2001	ALB
17	Primary protein-losing enteropathy in anti-double-stranded DNA disease: the initial and sole clinical manifestation of occult systemic lupus erythematosus? (11588554)	Northcott K.A.... Steinbrecher U.P.	2001	ALB
18	Reduced heparan sulfate accumulation in enterocytes contributes to protein-losing enteropathy in a congenital disorder of glycosylation. (11106564)	Westphal V.... Freeze H.H.	2000	ALG6
19	Resolution of protein-losing enteropathy with standard high molecular heparin and urokinase after Fontan repair in a patient with tricuspid atresia. (11052284)	Facchini M.... Attenhofer Jost C.H.	2000	ALB
20	99mTc-human serum albumin scans in children with protein-losing enteropathy. (10688102)	Halaby H.... Nazer H.	2000	ALB, OXA1L
21	Treatment of iron deficiency anemia and associated protein-losing enteropathy in children. (10695822)	Nickerson H.J.... Broste S.K.	2000	ALB
22	Protein-losing enteropathy in congestive heart failure: diagnosis by means of a simple method. (10430351)	Chan F.K.... Yeung V.T.	1999	ALB
23	Disseminated Langerhans' cell histiocytosis and massive protein-losing enteropathy. (10464385)	Santos-Machado T.M.... Odone-Filho V.	1999	ALB
24	Visualization of protein losing enteropathy in infantile systemic hyalinosis with Tc-99m HSA after albumin challenge. (8732848)	Shields E.... Chung C.J.	1996	ALB
25	Protein-losing enteropathy after the Fontan operation: successful treatment by percutaneous fenestration of the atrial septum. (8637261)	Warnes C.A.... Hagler D.J.	1996	ALB
26	Eosinophilic gastroenteritis presenting as protein--losing enteropathy (case report). (7732607)	Karademir S.... Ural C.	1995	IGES
27	Protein-losing enteropathy and cerebral infarction associated with systemic lupus erythematosus (8146730)	Murao S.... Yamana S.	1994	ALB
28	A case of protein-losing enteropathy in idiopathic th rombocytopenic purpura with decreased IgA. (8061805)	Kuroe K.... Yoshida Y.	1994	CD79A
29	Protein-losing enteropathy and hypoalbuminemia in AIDS. (8363760)	Laine L.... Thomas D.W.	1993	ALB
30	Protein-losing enteropathy in Transkeian children with morbid protein-energy malnutrition. (8211522)	Iputo J.E.	1993	ALB
31	Protein-losing enteropathy and pancreatic involvement in a case of connective tissue disease. (1577230)	Kashihara T.... Okuno G.	1992	ALB
32	Mixed connective tissue disease associated with protein losing enteropathy: successful treatment with intravenous cyclophosphamide therapy. (1300171)	Furuya T.... Kashiwazaki S.	1992	MUC16
33	Constrictive pericarditis without typical haemodynami c changes as a cause of oedema formation due to protein-losing enteropathy. (1782939)	MA1ller C.... Knoflach P.	1991	ALB
34	Imaging diagnosis of protein-losing enteropathy by 99mTc-labeled serum albumin (2290206)	Kashiwagi T.... Ida S.	1990	ALB

Genes related to protein-losing enteropathy according to GeneCards:

(show all 11)

id	Symbol	Description	Score	GeneCards Section Context
1	MPI	mannose phosphate isomerase	11.1	Publications
2	OXA1L	oxidase (cytochrome c) assembly 1-like	11.1	Publications
3	ALB	albumin	11.1	Publications
4	IGES	immunoglobulin E concentration, serum	11.1	Publications
5	SERPINA2	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2	11.1
6	ALG6	asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)	11.1	Publications
7	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.1
8	MUC16	mucin 16, cell surface associated	11.1	Publications
9	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.1	Publications
10	NPPB	natriuretic peptide B	11.1	Publications
11	TF	transferrin	11.1

Pathways related to protein-losing enteropathy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein38	9.8	MPI, ALG6

Compounds related to protein-losing enteropathy according to GeneDecks:

(show top 50)    (show all 96)

id	Compound	Score	Top Affiliating Genes
1	azapropazone32 9 9	12.3	OXA1L, ALB
2	sodium octanoate32	10.3	OXA1L, ALB
3	dansylsarcosine32	10.3	ALB, OXA1L
4	rhsa32	10.2	OXA1L, ALB
5	pirprofen32	10.2	ALB, OXA1L
6	tolmetin glucuronide32	10.2	ALB, OXA1L
7	kebuzone32	10.2	OXA1L, ALB
8	hhpa32	10.2	OXA1L, ALB
9	acetyldigitoxin32 9 9	12.2	OXA1L, ALB
10	dansylamide32 9 9	12.2	ALB, OXA1L
11	fenoprofen32 9 9	12.2	OXA1L, ALB
12	sulfisoxazole32 42 9 9	13.2	ALB, OXA1L
13	eprex32	10.2	OXA1L, ALB
14	oxyphenbutazone32 9 9	12.1	OXA1L, ALB
15	(s)-ketoprofen32	10.1	OXA1L, ALB
16	tolmetin32 9 9	12.1	OXA1L, ALB
17	cyclosarin32	10.1	ALB, OXA1L
18	kp-101932	10.0	TF, ALB
19	polyvinylpyrrolidone32	10.0	ALB, OXA1L
20	sinapic acid32	10.0	TF, OXA1L
21	indoxyl sulfate32	9.9	ALB, OXA1L
22	Bismuth Subsalicylate9 9	10.9	ALB, TF
23	n(epsilon)-(carboxymethyl)lysine32	9.9	ALB, OXA1L
24	phenylbutazone32 9 9	11.8	OXA1L, ALB, SERPINA1
25	glutaraldehyde32	9.8	CD79A, TF
26	suprofen32 9 9	11.8	TF, ALB, OXA1L
27	nitrilotriacetic acid32 9 9	11.8	OXA1L, TF
28	polyvinyl alcohol32	9.8	OXA1L, ALB
29	dtpa32	9.7	ALB, OXA1L, TF
30	piroxicam32 42 9 9	12.7	OXA1L, ALB, CD79A
31	cellulose acetate32	9.6	ALB, MPI, CD79A
32	glucose32	9.6	MPI, MUC16, SERPINA2
33	phenytoin32 34 9 9	12.5	ALB, CD79A, OXA1L
34	salicylic acid32	9.4	SERPINA1, OXA1L, ALB
35	furosemide32 42 34 9 18 9	14.4	NPPB, OXA1L, ALB
36	warfarin32 34 9 18 9	13.4	OXA1L, ALB, CD79A
37	polyethylene glycol32	9.1	TF, CD79A, ALB, OXA1L
38	ramipril32 9 9	11.1	NPPB, CD79A, ALB
39	enterotoxin32	9.1	CD79A, IGES, NPPB
40	captopril32 42 9 9	12.0	ALB, NPPB, CD79A
41	aspirin32 34 18	10.7	CD79A, IGES, NPPB, OXA1L
42	bicarbonate32	8.7	NPPB, TF, ALB, MUC16
43	vitamin b1232	8.7	TF, ALB, CD79A
44	thyroxine32 18	9.3	CD79A, NPPB, OXA1L, TF, ALB
45	histamine32 18	9.3	NPPB, TF, IGES, ALB, CD79A
46	fibrinogen32	8.2	CD79A, OXA1L, SERPINA1, MUC16, TF, ALB
47	prednisolone32 9 9	10.1	TF, NPPB, ALB, MUC16, CD79A
48	iron32 18	8.9	TF, MUC16, SERPINA1, NPPB, SERPINA2, ALB
49	lactate32	7.8	ALB, MUC16, CD79A, IGES, TF, NPPB
50	creatinine32	7.6	TF, NPPB, SERPINA1, MUC16, CD79A, ALB

Biological processes related to protein-losing enteropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	post-translational protein modification	GO:043687	9.3	MUC16, MPI, ALG6
2	platelet degranulation	GO:002576	8.9	SERPINA1, ALB, TF