MCID: PRT019
MIFTS: 41

Protein-Losing Enteropathy malady

Category: Gastrointestinal diseases

Aliases & Classifications for Protein-Losing Enteropathy

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Aliases & Descriptions for Protein-Losing Enteropathy:

Name: Protein-Losing Enteropathy 11 26 13
Protein-Losing Enteropathies 49 38 67
 
Enteropathy, Exudative 11
Exudative Enteropathy 11

Characteristics:


Classifications:



External Ids:

Disease Ontology11 DOID:10611
SNOMED-CT61 22542007, 66972006
MeSH38 D011504

Summaries for Protein-Losing Enteropathy

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Wikipedia:70 Protein losing enteropathy refers to any condition of the gastrointestinal tract (e.g. damage to the gut... more...

MalaCards based summary: Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to adenocarcinoma and lymphedema, and has symptoms including edema, clubbing and growth delay. An important gene associated with Protein-Losing Enteropathy is MPI (Mannose Phosphate Isomerase), and among its related pathways are N-Glycan biosynthesis and Synthesis of substrates in N-glycan biosythesis. Affiliated tissues include heart, small intestine and liver.

Related Diseases for Protein-Losing Enteropathy

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Diseases related to Protein-Losing Enteropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.2ALB, CD79A
2lymphedema29.6ALB, SERPINA1
3congenital disorder of glycosylation, type ib12.0
4congenital diarrhea 7 with exudative enteropathy11.7
5lymphangiectasis11.4
6diarrhea 711.2
7congenital disorder of glycosylation, type ic11.0
8lupus erythematosus10.6
9systemic lupus erythematosus10.6
10congenital disorder of glycosylation, type in10.4ALG6, MPI
11boutonneuse fever10.4ALB, CD79A
12vesicoureteral reflux10.4ALB, CD79A
13testicular brenner tumor10.4ALB, CD79A
14hematocele of tunica vaginalis testis10.4ALB, CD79A
15lymphoma10.4
16adie pupil10.4ALB, CD79A
17mesangial proliferative glomerulonephritis10.4ALB, CD79A
18smoldering myeloma10.4ALB, CD79A
19chromoblastomycosis10.4ALB, CD79A
20tarp syndrome10.3ALB, CD79A
21spastic monoplegia10.3ALB, CD79A
22mast cell neoplasm10.3ALB, CD79A
23polysyndactyly with cardiac malformation10.3ALB, SERPINA1
24balantidiasis10.3ALB, CD79A
25horner's syndrome10.3ALB, SERPINA1
26autoimmune disease of cardiovascular system10.3ALB, CD79A
27hyperuricemia10.3ALB, SERPINA1
28pericarditis10.3
29urinary bladder posterior wall cancer10.3ALB, CD79A
30duodenal disease10.3ALB, SERPINA1
31lacrimal gland carcinoma10.3ALB, CD79A
32kidney angiomyolipoma10.3ALB, CD79A
33orofaciodigital syndrome vii10.3ALB, SERPINA1
34colitis10.3
35constrictive pericarditis10.3
36pancreatic vasoactive intestinal peptide producing tumor10.3ALB, CD79A
37benign lymphoepithelial lesion of salivary gland10.3ALB, CD79A
38sweat gland cancer10.3ALB, SERPINA1
39achilles bursitis10.3ALB, CD79A
40heart disease10.3
41gastroenteritis10.3
42eosinophilic gastroenteritis10.3
43sarcoid meningitis10.3ALB, CD79A
44pompholyx10.3CD79A, SERPINA1
45extrahepatic cholestasis10.3ALB, CD79A
46contagious pustular dermatitis10.3ALB, SERPINA1
47amyloidosis10.3
48nasopharyngeal carcinoma 210.2ALB, CD79A
49aniseikonia10.2CD79A, SERPINA1
50granular cell tumor10.2CD79A, SERPINA1

Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to protein-losing enteropathy

Symptoms for Protein-Losing Enteropathy

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Human phenotypes related to Protein-Losing Enteropathy:

 63 (show all 10)
id Description HPO Frequency HPO Source Accession
1 edema63 HP:0000969
2 clubbing63 HP:0001217
3 growth delay63 HP:0001510
4 ascites63 HP:0001541
5 iron deficiency anemia63 HP:0001891
6 diarrhea63 HP:0002014
7 abdominal pain63 HP:0002027
8 abnormality of the intestine63 HP:0002242
9 budd-chiari syndrome63 HP:0002639
10 hypoproteinemia63 HP:0003075

Drugs & Therapeutics for Protein-Losing Enteropathy

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Drugs for Protein-Losing Enteropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Heparinapproved, investigationalPhase 18129005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
2calcium heparinPhase 1812
3
Substance Pinvestigational24533507-63-044359816
Synonyms:
 
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
4Vasodilator Agents3438
5Vasoactive intestinal peptide640077-57-4
6Neuroprotective Agents1672
7Gastrointestinal Agents8109
8neurokinin A249
9Protective Agents7190

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pilot/Ph I Safety and Efficacy of ODSH in Protein Losing Enteropathy Secondary to Single Ventricle Palliative SurgeryTerminatedNCT01161641Phase 1
2Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle PhysiologyCompletedNCT01563757
3International Lymphatic Disease and Lymphedema RegistryRecruitingNCT01336790

Search NIH Clinical Center for Protein-Losing Enteropathy


Cochrane evidence based reviews: protein-losing enteropathies

Genetic Tests for Protein-Losing Enteropathy

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Genetic tests related to Protein-Losing Enteropathy:

id Genetic test Affiliating Genes
1 Enteropathy, Protein-Losing26

Anatomical Context for Protein-Losing Enteropathy

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MalaCards organs/tissues related to Protein-Losing Enteropathy:

35
Heart, Small intestine, Liver, Colon, Testes, Bone, T cells

Animal Models for Protein-Losing Enteropathy or affiliated genes

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Publications for Protein-Losing Enteropathy

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Articles related to Protein-Losing Enteropathy:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Hypoadrenocorticism mimicking protein-losing enteropathy in 4 dogs. (27429465)
2016
2
Oral budesonide as a therapy for protein-losing enteropathy in children after the Fontan operation. (24889258)
2014
3
Comparison of a chlorambucil-prednisolone combination with an azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007-2010). (23725434)
2013
4
Chronic diarrhea, ascites, and protein-losing enteropathy in an infant with hepatic venous outflow obstruction after liver transplantation. (22489846)
2012
5
Recurrent protein-losing enteropathy and tricuspid valve insufficiency in a transplanted heart: a causal relationship? (21801319)
2012
6
Protein-losing enteropathy and premature ovarian failure in a young woman with systemic lupus erythematosus. (22627066)
2012
7
Children with protein-losing enteropathy after the Fontan operation are at risk for abnormal bone mineral density. (22434509)
2012
8
Protein-losing enteropathy resolved by percutaneous intervention. (21805565)
2011
9
Protein-losing enteropathy caused by spontaneous superior mesenteric artery dissection with thrombosis. (21086951)
2010
10
Acute right ventricular failure in lupus-associated protein-losing enteropathy. (20837273)
2010
11
Recurrent exacerbations of protein-losing enteropathy after initiation of growth hormone therapy in a Fontan patient controlled with spironolactone. (20412490)
2010
12
Protein-losing enteropathy with mesenteric venous thrombosis: a forme fruste of systemic lupus erythematosus. (19812125)
2009
13
Protein-losing enteropathy post-valvular surgery with severe tricuspid regurgitation in Subutex-related endocarditis. (19421664)
2009
14
New thinking about postoperative hypoalbuminemia: a hypothesis of occult protein-losing enteropathy. (21688758)
2009
15
Protein-losing enteropathy in systemic lupus erythematosus: analysis of the clinical features of fifteen patients. (18176138)
2007
16
Intestinal lymphangiectasia with protein-losing enteropathy in Waldenstrom macroglobulinemia. (17632262)
2007
17
Resolution of protein-losing enteropathy after radiofrequency perforation and subsequent stent implantation for relief of complete occlusion of a redirected left superior vena cava. (16764003)
2006
18
Scintigraphic diagnosis of protein-losing enteropathy secondary to amyloidosis. (16252188)
2005
19
Protein-losing enteropathy in Crohn's disease. (15952090)
2005
20
Protein-losing enteropathy. (15557963)
2004
21
A case of severe protein-losing enteropathy as a late complication of pelvic irradiation. (15683118)
2004
22
Protein-losing enteropathy detected on Tc-99m HSA and Tc-99m MDP scintigraphy. (12045436)
2002
23
Protein-losing enteropathy complicated with recurrent convulsions and developmental delay in a 4-month-old boy. (12421272)
2002
24
Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology. (11958575)
2002
25
Congenital intestinal lymphatic hypoplasia presenting as non-immune hydrops in utero, and subsequent neonatal protein-losing enteropathy. (12454588)
2002
26
Protein-losing enteropathy: diagnosis with (99m)Tc-labeled human serum albumin scintigraphy. (11274540)
2001
27
Protein-losing enteropathy in a young African-American woman with abdominal pain, diarrhea and hydronephrosis. (11787872)
2001
28
Heparin therapy and reversal of protein-losing enteropathy in a case with congenital heart disease. (10818189)
2000
29
Protein-losing enteropathy with an endoscopic feature of 'the watermelon colon'. (10755263)
1999
30
Phosphomannose isomerase deficiency as a cause of congenital hepatic fibrosis and protein-losing enteropathy. (10488719)
1999
31
Protein losing enteropathy as the initial manifestation of childhood systemic lupus erythematosus. (8823704)
1996
32
Visualization of protein losing enteropathy in infantile systemic hyalinosis with Tc-99m HSA after albumin challenge. (8732848)
1996
33
Protein-losing enteropathy from cap polyposis. (7491082)
1995
34
Diagnosing protein losing enteropathy. A new approach using Tc-99m human immunoglobulin. (8565376)
1995
35
Protein-losing enteropathy and pancreatic involvement in a case of connective tissue disease. (1577230)
1992
36
Cellular immunodeficiency in protein-losing enteropathy. Predominant reduction of CD3+ and CD4+ lymphocytes. (1670632)
1991
37
Tc-99m human serum albumin abdominal scanning in protein-losing enteropathy. (2258219)
1990
38
Protein losing enteropathy in the different forms of protein-energy malnutrition. (3123710)
1987
39
Transient protein losing enteropathy associated with acute gastritis and campylobacter pylori. (3435155)
1987
40
Protein-losing enteropathy caused by systemic lupus erythematosus. (18668866)
1985
41
Protein-losing enteropathy with small intestinal stenoses and a stagnant loop in a nine-year-old boy. (7136667)
1982
42
Protein-losing enteropathy in a boy with systemic lupus erythematosus. (7431171)
1980
43
Protein-losing enteropathy due to gastro-intestinal amyloidosis. (523374)
1979
44
Severe enamel hypoplasia in a case of intestinal lymphangiectasia: a rare protein-losing enteropathy. (266150)
1977
45
Transient protein-losing enteropathy secondary to elevated caval pressures and caval obstruction after the Mustard procedure. (957755)
1976
46
Protein-losing enteropathy and malabsorption in regional enteritis: cure by limited ileal resection. (4748296)
1973
47
Gastrointestinal polyposis with protein-losing enteropathy, abnormal skin pigmentation and loss of hair and nails (Cronkhite-Canada syndrome). (5808657)
1969
48
Dietary treatment of protein-losing enteropathy. (6072275)
1967
49
Idiopathic retroperitoneal fibrosis with protein-losing enteropathy and duodenal obstruction successfully treated with corticosteroids. (5921477)
1966
50
Protein-losing enteropathy. (5324268)
1966

Variations for Protein-Losing Enteropathy

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Expression for genes affiliated with Protein-Losing Enteropathy

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Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for genes affiliated with Protein-Losing Enteropathy

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GO Terms for genes affiliated with Protein-Losing Enteropathy

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Cellular components related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6ALB, SERPINA1

Biological processes related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oligosaccharide-lipid intermediate biosynthetic processGO:00064909.7ALG6, ALG8
2dolichol-linked oligosaccharide biosynthetic processGO:00064889.2ALG6, ALG8
3protein N-linked glycosylationGO:00064879.2ALG6, ALG8

Molecular functions related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activityGO:00422819.2ALG6, ALG8
2dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activityGO:00045838.9ALG6, ALG8

Sources for Protein-Losing Enteropathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet