MCID: PRT019
MIFTS: 50

Protein-Losing Enteropathy malady

Gastrointestinal diseases category
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Summaries for Protein-Losing Enteropathy

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Sources:
65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Protein losing enteropathy refers to any condition of the gastrointestinal tract that results in a net... more...

MalaCards: Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to gastroenteritis and congenital heart disease. An important gene associated with Protein-Losing Enteropathy is MPI (mannose phosphate isomerase), and among its related pathways are Selected targets of HNF1 and Selected targets of C EBPalpha. The compounds tolmetin glucuronide and pirprofen have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and liver.

Description from OMIM:47 226300

Aliases & Classifications for Protein-Losing Enteropathy

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 47OMIM, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

protein-losing enteropathy 8 10
protein-losing enteropathies 45 62
enteropathy, exudative 8
exudative enteropathy 8


External Ids:

Disease Ontology8 DOID:10611
OMIM47 226300
SNOMED-CT58 22542007, 66972006
MeSH35 D011504

Related Diseases for Protein-Losing Enteropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Protein-Losing Enteropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1gastroenteritis31.2CD79A
2congenital heart disease31.0CD79A, NPPB, ALB
3amyloidosis31.0ALB, NPPB, CD79A
4connective tissue disease30.9CD79A, ALB
5hepatitis30.9ALB, SERPINA1, TF
6diarrhea30.9ALB, CD79A
7hypertension30.8ALB, NPPB, CD79A
8congenital disorder of glycosylation30.7MPI, ALG6
9protein-energy malnutrition30.6ALB, TF
10bronchitis30.6SERPINA1, CD79A
11deficiency anemia30.5CD79A, ALB, TF
12liver cirrhosis30.5ALB, SERPINA1, TF
13pneumonia30.5CD79A, OXA1L, SERPINA1
14pulmonary embolism30.4ALB, NPPB
15lupus nephritis30.4CD79A, ALB
16nephritis30.3CD79A, ALB
17ankylosing spondylitis30.3SERPINA1, CD79A
18vasculitis30.3SERPINA1, ALB, CD79A
19lupus erythematosus11.0
20systemic lupus erythematosus11.0
21intestinal lymphangiectasia10.8
22eosinophilic gastroenteritis10.7
23constrictive pericarditis10.7
24pericarditis10.7
25purpura10.6
26crohn's disease10.5
27cronkhite-canada syndrome10.5
28ulcerative colitis10.5
29arthritis10.5
30dermatitis10.5
31rheumatoid arthritis10.5
32lymphangiomatosis10.5
33langerhans-cell histiocytosis10.5
34portal hypertension10.5
35giardiasis10.5
36measles10.5
37kaposi's sarcoma10.5
38mixed connective tissue disease10.5
39food allergy10.5
40histiocytosis10.5
41lymphedema10.5
42neuroblastoma10.5
43sarcoidosis10.5
44sarcoma10.5
45congenital hepatic fibrosis10.5
46collagenous colitis10.5
47lymphangiectasis10.5
48cap polyposis10.5
49graft versus host disease10.4
50follicular lymphoma10.4

Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to protein-losing enteropathy

Symptoms for Protein-Losing Enteropathy

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Sources:
47OMIM
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Clinical features from OMIM:

226300

Drugs & Therapeutics for Protein-Losing Enteropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Protein-Losing Enteropathy

Search NIH Clinical Center for Protein-Losing Enteropathy

Genetic Tests for Protein-Losing Enteropathy

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Anatomical Context for Protein-Losing Enteropathy

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33MalaCards
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MalaCards organs/tissues related to Protein-Losing Enteropathy:

33
Heart, Small intestine, Liver, Colon, Bone, Testes, Bone marrow, Lymph node, Lung, Thyroid, Breast, T cells, B cells, Skin

Animal Models for Protein-Losing Enteropathy or affiliated genes

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Publications for Protein-Losing Enteropathy

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Sources:
52PubMed
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Articles related to Protein-Losing Enteropathy:

(show top 50)    (show all 491)
idTitleAuthorsYear
1
Comparison of a chlorambucil-prednisolone combination with an azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007-2010). (23725434)
2013
2
Use of oral budesonide in the management of protein-losing enteropathy due to restrictive cardiomyopathy. (24029379)
2013
3
Progressive mesenteric lymphadenopathy with protein-losing enteropathy; a devastating complication in Gaucher disease. (22227073)
2012
4
Recurrent protein-losing enteropathy and tricuspid valve insufficiency in a transplanted heart: a causal relationship? (21801319)
2012
5
Protein-Losing Enteropathy in a Post-partum Female Secondary to Metastatic Melanoma of the Gut: Report of a Case. (22006436)
2011
6
Protein-losing enteropathy caused by spontaneous superior mesenteric artery dissection with thrombosis. (21086951)
2010
7
Protein-losing enteropathy associated with Henoch-SchAPnlein purpura. (21589833)
2010
8
Protein-losing enteropathy with mesenteric venous thrombosis: a forme fruste of systemic lupus erythematosus. (19812125)
2009
9
Protein-losing enteropathy post-valvular surgery with severe tricuspid regurgitation in Subutex-related endocarditis. (19421664)
2009
10
Protein-losing enteropathy after the Fontan operation: associations and predictors of clinical outcome. (18715460)
2008
11
Protein-losing enteropathy detected by Tc-99m-MDP abdominal scintigraphy. (18604530)
2008
12
Protein-losing enteropathy in systemic lupus erythematosus: analysis of the clinical features of fifteen patients. (18176138)
2007
13
Resolution of protein-losing enteropathy after radiofrequency perforation and subsequent stent implantation for relief of complete occlusion of a redirected left superior vena cava. (16764003)
2006
14
Scintigraphic diagnosis of protein-losing enteropathy secondary to amyloidosis. (16252188)
2005
15
Protein-losing enteropathy in Crohn's disease. (15952090)
2005
16
Protein-losing enteropathy. (15557963)
2004
17
A case of severe protein-losing enteropathy as a late complication of pelvic irradiation. (15683118)
2004
18
Reversal of protein-losing enteropathy with calcium replacement in a patient after Fontan operation. (15063295)
2004
19
Protein-losing enteropathy caused by Lawsonia intracellularis in a weanling foal. (12619560)
2003
20
Protein-losing enteropathy detected on Tc-99m HSA and Tc-99m MDP scintigraphy. (12045436)
2002
21
Protein-losing enteropathy complicated with recurrent convulsions and developmental delay in a 4-month-old boy. (12421272)
2002
22
Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology. (11958575)
2002
23
Right ventricular cardiomyopathy accompanied by protein-losing enteropathy and chylous effusion. (11665798)
2001
24
Treatment of iron deficiency anemia and associated protein-losing enteropathy in children. (10695822)
2000
25
Heparin therapy and reversal of protein-losing enteropathy in a case with congenital heart disease. (10818189)
2000
26
Protein-losing enteropathy with an endoscopic feature of 'the watermelon colon'. (10755263)
1999
27
Transjugular intrahepatic portosystemic shunt as a treatment for protein-losing enteropathy caused by portal hypertension. (8942750)
1996
28
Protein losing enteropathy as the initial manifestation of childhood systemic lupus erythematosus. (8823704)
1996
29
Protein-losing enteropathy after the modified fontan operation: oral prednisone treatment with biopsy and laboratory proved improvement. (8833498)
1996
30
Generalized giant inflammatory polyposis in a patient with ulcerative colitis presenting with protein-losing enteropathy. (7733100)
1995
31
Protein-losing enteropathy from cap polyposis. (7491082)
1995
32
A case of protein-losing enteropathy in idiopathic thrombocytopenic purpura with decreased IgA. (8061805)
1994
33
Oral administration of cromolyn in a patient with protein-losing enteropathy, food allergy, and eosinophilic gastroenteritis. (8170195)
1994
34
Protein-losing enteropathy with collagenous colitis. (1590320)
1992
35
Protein-losing enteropathy following the Fontan operation: resolution with prednisone therapy. (1990777)
1991
36
Tc-99m human serum albumin abdominal scanning in protein-losing enteropathy. (2258219)
1990
37
Protein-losing enteropathy detected by 99mTc-labeled human serum albumin abdominal scintigraphy. (3264334)
1988
38
Pure red cell aplasia and protein-losing enteropathy in a patient with systemic lupus erythematosus. (3929798)
1985
39
Administration of intravenous immunoglobulin in two children with hypogammaglobulinaemia due to protein losing enteropathy. (4006307)
1985
40
Protein-losing enteropathy caused by systemic lupus erythematosus. (18668866)
1985
41
Protein-losing enteropathy with small intestinal stenoses and a stagnant loop in a nine-year-old boy. (7136667)
1982
42
Congenital Letterer-Siwe disease associated with protein losing enteropathy. (7449792)
1980
43
Congenital hepatic fibrosis combined with protein-losing enteropathy and recurrent thrombosis. (7446108)
1980
44
Protein-losing enteropathy in a boy with systemic lupus erythematosus. (7431171)
1980
45
Protein-losing enteropathy due to gastro-intestinal amyloidosis. (523374)
1979
46
Budd-Chiari syndrome associated with protein-losing enteropathy. (401086)
1978
47
Severe enamel hypoplasia in a case of intestinal lymphangiectasia: a rare protein-losing enteropathy. (266150)
1977
48
Protein-losing enteropathy and malabsorption in regional enteritis: cure by limited ileal resection. (4748296)
1973
49
Protein-losing enteropathy caused by a retained intestinal tube. (5413020)
1970
50
Gastrointestinal polyposis with protein-losing enteropathy, abnormal skin pigmentation and loss of hair and nails (Cronkhite-Canada syndrome). (5808657)
1969

Variations for Protein-Losing Enteropathy

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Expression for genes affiliated with Protein-Losing Enteropathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Protein-Losing Enteropathy

Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for genes affiliated with Protein-Losing Enteropathy

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50PathCards, 12EMD Millipore, 55Reactome
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Pathways related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4SERPINA1, ALB
29.2ALB, TF
3
Show member pathways
8.6ALB, SERPINA1, TF
4
Show member pathways
8.6ALB, SERPINA1, TF

Compounds for genes affiliated with Protein-Losing Enteropathy

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1tolmetin glucuronide4510.0ALB, OXA1L
2pirprofen4510.0ALB, OXA1L
3kebuzone4510.0ALB, OXA1L
4rhsa459.9ALB, OXA1L
5sodium octanoate459.9OXA1L, ALB
6dansylsarcosine459.9OXA1L, ALB
7azapropazone45 1110.9ALB, OXA1L
8hhpa459.9ALB, OXA1L
9acetyldigitoxin45 1110.9ALB, OXA1L
10eprex459.9OXA1L, ALB
11dansylamide45 1110.9OXA1L, ALB
12cyclosarin459.8ALB, OXA1L
13fenoprofen29 45 1111.8OXA1L, ALB
14(s)-ketoprofen459.8OXA1L, ALB
15sulfisoxazole45 51 61 1112.8ALB, OXA1L
16polyvinylpyrrolidone459.8ALB, OXA1L
17oxyphenbutazone45 1110.7ALB, OXA1L
18n(epsilon)-(carboxymethyl)lysine459.7ALB, OXA1L
19cellulose acetate459.7CD79A, ALB, MPI
20indoxyl sulfate459.7ALB, OXA1L
21kp-1019459.6TF, ALB
22polyvinyl alcohol459.6ALB, OXA1L
23sinapic acid459.5TF, OXA1L
24ramipril45 1110.5NPPB, ALB, CD79A
25piroxicam45 1110.5CD79A, ALB, OXA1L
26captopril45 61 51 29 1113.5ALB, NPPB, CD79A
27phenytoin45 51 29 1112.5CD79A, ALB, OXA1L
28warfarin45 51 24 1112.4CD79A, OXA1L, ALB
29furosemide45 61 29 51 24 1114.4OXA1L, ALB, NPPB
30phenylbutazone45 1110.4OXA1L, ALB, SERPINA1
31nitrilotriacetic acid45 1110.3TF, OXA1L
32tolmetin45 1110.2ALB, OXA1L
33salicylic acid45 2910.2OXA1L, ALB, SERPINA1
34suprofen45 1110.2OXA1L, TF, ALB
35dtpa459.1ALB, OXA1L, TF
36vitamin b12459.1ALB, CD79A, TF
37sodium dodecylsulfate459.1CD79A, ALB, OXA1L
38bicarbonate459.0ALB, TF, NPPB
39glutaraldehyde458.7TF, OXA1L, ALB, CD79A
40polyethylene glycol458.7OXA1L, TF, ALB, CD79A
41prednisolone45 29 1110.7CD79A, NPPB, ALB, TF
42tacrolimus45 51 1110.7TF, ALB, NPPB, CD79A
43histamine45 29 2410.6NPPB, ALB, TF, CD79A
44ascorbic acid45 249.5SERPINA1, TF, ALB, CD79A
45cysteine458.2ALB, OXA1L, NPPB, CD79A, SERPINA1
46thyroxine45 249.2TF, OXA1L, ALB, NPPB, CD79A
47lactate458.2TF, ALB, CD79A, NPPB
48iron45 249.1ALB, NPPB, SERPINA1, TF
49fibrinogen458.1TF, SERPINA1, OXA1L, ALB, CD79A
50creatinine458.1CD79A, TF, SERPINA1, ALB, NPPB

GO Terms for genes affiliated with Protein-Losing Enteropathy

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16Gene Ontology
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Cellular components related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.1ALB, SERPINA1
2protein complexGO:0432349.0NPPB, ALB, OXA1L
3extracellular regionGO:0055768.1NPPB, ALB, SERPINA1, TF
4extracellular spaceGO:0056158.0TF, SERPINA1, ALB, NPPB

Biological processes related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dolichol-linked oligosaccharide biosynthetic processGO:0064889.7MPI, ALG6
2retina homeostasisGO:0018958.9ALB, TF
3platelet degranulationGO:0025768.7ALB, SERPINA1, TF
4platelet activationGO:0301688.6ALB, SERPINA1, TF
5blood coagulationGO:0075968.6ALB, SERPINA1, TF

Products for genes affiliated with Protein-Losing Enteropathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Protein-Losing Enteropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet