MCID: PRT019
MIFTS: 40

Protein-Losing Enteropathy malady

Gastrointestinal diseases category

Aliases & Classifications for Protein-Losing Enteropathy

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Sources:
10Disease Ontology, 12DISEASES, 47Novoseek, 65UMLS, 36MeSH, 59SNOMED-CT
See all sources

Aliases & Descriptions for Protein-Losing Enteropathy:

Name: Protein-Losing Enteropathy 10 12
Protein-Losing Enteropathies 47 65 36
 
Enteropathy, Exudative 10
Exudative Enteropathy 10


Classifications:



External Ids:

Disease Ontology10 DOID:10611
SNOMED-CT59 66972006, 22542007
MeSH36 D011504

Summaries for Protein-Losing Enteropathy

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Wikipedia:68 Protein-losing enteropathy refers to any condition of the gastrointestinal tract that results in a net... more...

MalaCards based summary: Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to lupus erythematosus and systemic lupus erythematosus, and has symptoms including autosomal recessive inheritance, edema and clubbing. An important gene associated with Protein-Losing Enteropathy is MPI (Mannose Phosphate Isomerase), and among its related pathways are N-Glycan biosynthesis and Synthesis of substrates in N-glycan biosythesis. Affiliated tissues include heart, liver and small intestine.

Related Diseases for Protein-Losing Enteropathy

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Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to protein-losing enteropathy

Symptoms for Protein-Losing Enteropathy

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HPO human phenotypes related to Protein-Losing Enteropathy:

(show all 11)
id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 edema HP:0000969
3 clubbing HP:0001217
4 growth delay HP:0001510
5 ascites HP:0001541
6 iron deficiency anemia HP:0001891
7 diarrhea HP:0002014
8 abdominal pain HP:0002027
9 abnormality of the intestine HP:0002242
10 budd-chiari syndrome HP:0002639
11 hypoproteinemia HP:0003075

Drugs & Therapeutics for Protein-Losing Enteropathy

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Drugs for Protein-Losing Enteropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Heparinapproved, investigationalPhase 16729005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
2calcium heparinPhase 1672
3
substance Pinvestigational20433507-63-036511, 44359816
Synonyms:
 
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
4Vasoactive intestinal peptide640077-57-4
5neurokinin A206

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pilot/Ph I Safety and Efficacy of ODSH in Protein Losing Enteropathy Secondary to Single Ventricle Palliative SurgeryTerminatedNCT01161641Phase 1
2Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle PhysiologyCompletedNCT01563757
3National Lymphatic Disease and Lymphedema RegistryRecruitingNCT01336790

Search NIH Clinical Center for Protein-Losing Enteropathy


Cochrane evidence based reviews: Protein-Losing Enteropathies

Genetic Tests for Protein-Losing Enteropathy

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Anatomical Context for Protein-Losing Enteropathy

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MalaCards organs/tissues related to Protein-Losing Enteropathy:

33
Heart, Liver, Small intestine, Bone, Colon, Testes, T cells

Animal Models for Protein-Losing Enteropathy or affiliated genes

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Publications for Protein-Losing Enteropathy

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Articles related to Protein-Losing Enteropathy:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
Fontan-associated protein-losing enteropathy and heart transplant: A Pediatric Heart Transplant Study analysis. (25987313)
2015
2
Gastrointestinal: Endoscopic findings of collagenous gastroenterocolitis with protein-losing enteropathy. (25916480)
2015
3
Oral budesonide as a therapy for protein-losing enteropathy in children after the Fontan operation. (24889258)
2014
4
Comparison of a chlorambucil-prednisolone combination with an azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007-2010). (23725434)
2013
5
Use of oral budesonide in the management of protein-losing enteropathy due to restrictive cardiomyopathy. (24029379)
2013
6
Progressive mesenteric lymphadenopathy with protein-losing enteropathy; a devastating complication in Gaucher disease. (22227073)
2012
7
Chronic diarrhea, ascites, and protein-losing enteropathy in an infant with hepatic venous outflow obstruction after liver transplantation. (22489846)
2012
8
Recurrent protein-losing enteropathy and tricuspid valve insufficiency in a transplanted heart: a causal relationship? (21801319)
2012
9
Protein-losing enteropathy caused by spontaneous superior mesenteric artery dissection with thrombosis. (21086951)
2010
10
Protein-losing enteropathy associated with Henoch-SchAPnlein purpura. (21589833)
2010
11
Protein-losing enteropathy with mesenteric venous thrombosis: a forme fruste of systemic lupus erythematosus. (19812125)
2009
12
Protein-losing enteropathy post-valvular surgery with severe tricuspid regurgitation in Subutex-related endocarditis. (19421664)
2009
13
Protein-losing enteropathy after the Fontan operation: associations and predictors of clinical outcome. (18715460)
2008
14
Protein-losing enteropathy detected by Tc-99m-MDP abdominal scintigraphy. (18604530)
2008
15
Protein-losing enteropathy in systemic lupus erythematosus: analysis of the clinical features of fifteen patients. (18176138)
2007
16
Resolution of protein-losing enteropathy after radiofrequency perforation and subsequent stent implantation for relief of complete occlusion of a redirected left superior vena cava. (16764003)
2006
17
Scintigraphic diagnosis of protein-losing enteropathy secondary to amyloidosis. (16252188)
2005
18
Protein-losing enteropathy. (15557963)
2004
19
A case of severe protein-losing enteropathy as a late complication of pelvic irradiation. (15683118)
2004
20
Protein-losing enteropathy caused by Lawsonia intracellularis in a weanling foal. (12619560)
2003
21
Protein-losing enteropathy detected on Tc-99m HSA and Tc-99m MDP scintigraphy. (12045436)
2002
22
Protein-losing enteropathy complicated with recurrent convulsions and developmental delay in a 4-month-old boy. (12421272)
2002
23
Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology. (11958575)
2002
24
Right ventricular cardiomyopathy accompanied by protein-losing enteropathy and chylous effusion. (11665798)
2001
25
Treatment of iron deficiency anemia and associated protein-losing enteropathy in children. (10695822)
2000
26
Heparin therapy and reversal of protein-losing enteropathy in a case with congenital heart disease. (10818189)
2000
27
Protein-losing enteropathy with an endoscopic feature of 'the watermelon colon'. (10755263)
1999
28
Transjugular intrahepatic portosystemic shunt as a treatment for protein-losing enteropathy caused by portal hypertension. (8942750)
1996
29
Protein losing enteropathy as the initial manifestation of childhood systemic lupus erythematosus. (8823704)
1996
30
Protein-losing enteropathy after the modified fontan operation: oral prednisone treatment with biopsy and laboratory proved improvement. (8833498)
1996
31
Generalized giant inflammatory polyposis in a patient with ulcerative colitis presenting with protein-losing enteropathy. (7733100)
1995
32
Protein-losing enteropathy from cap polyposis. (7491082)
1995
33
A case of protein-losing enteropathy in idiopathic thrombocytopenic purpura with decreased IgA. (8061805)
1994
34
Oral administration of cromolyn in a patient with protein-losing enteropathy, food allergy, and eosinophilic gastroenteritis. (8170195)
1994
35
Protein-losing enteropathy with collagenous colitis. (1590320)
1992
36
Tc-99m human serum albumin abdominal scanning in protein-losing enteropathy. (2258219)
1990
37
Protein-losing enteropathy detected by 99mTc-labeled human serum albumin abdominal scintigraphy. (3264334)
1988
38
Pure red cell aplasia and protein-losing enteropathy in a patient with systemic lupus erythematosus. (3929798)
1985
39
Administration of intravenous immunoglobulin in two children with hypogammaglobulinaemia due to protein losing enteropathy. (4006307)
1985
40
Protein-losing enteropathy caused by systemic lupus erythematosus. (18668866)
1985
41
Protein-losing enteropathy with small intestinal stenoses and a stagnant loop in a nine-year-old boy. (7136667)
1982
42
Congenital Letterer-Siwe disease associated with protein losing enteropathy. (7449792)
1980
43
Congenital hepatic fibrosis combined with protein-losing enteropathy and recurrent thrombosis. (7446108)
1980
44
Protein-losing enteropathy in a boy with systemic lupus erythematosus. (7431171)
1980
45
Protein-losing enteropathy due to gastro-intestinal amyloidosis. (523374)
1979
46
Budd-Chiari syndrome associated with protein-losing enteropathy. (401086)
1978
47
Severe enamel hypoplasia in a case of intestinal lymphangiectasia: a rare protein-losing enteropathy. (266150)
1977
48
Protein-losing enteropathy and malabsorption in regional enteritis: cure by limited ileal resection. (4748296)
1973
49
Protein-losing enteropathy caused by a retained intestinal tube. (5413020)
1970
50
Gastrointestinal polyposis with protein-losing enteropathy, abnormal skin pigmentation and loss of hair and nails (Cronkhite-Canada syndrome). (5808657)
1969

Variations for Protein-Losing Enteropathy

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Expression for genes affiliated with Protein-Losing Enteropathy

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Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for genes affiliated with Protein-Losing Enteropathy

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GO Terms for genes affiliated with Protein-Losing Enteropathy

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Cellular components related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6ALB, SERPINA1

Biological processes related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:000257610.0ALB, SERPINA1
2oligosaccharide-lipid intermediate biosynthetic processGO:000649010.0ALG6, ALG8
3protein N-linked glycosylationGO:00064879.4ALG6, ALG8
4dolichol-linked oligosaccharide biosynthetic processGO:00064889.0ALG6, ALG8, MPI
5protein N-linked glycosylation via asparagineGO:00182798.4ALG6, ALG8, MPI, SERPINA1
6cellular protein metabolic processGO:00442678.4ALG6, ALG8, MPI, SERPINA1
7post-translational protein modificationGO:00436878.1ALG6, ALG8, MPI, SERPINA1

Molecular functions related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activityGO:00422819.8ALG6, ALG8
2protease bindingGO:00020209.4CCBE1, SERPINA1
3transferase activity, transferring hexosyl groupsGO:00167589.2ALG6, ALG8

Sources for Protein-Losing Enteropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet