MCID: PRT019
MIFTS: 46

Protein-Losing Enteropathy malady

Gastrointestinal category

Summaries for Protein-Losing Enteropathy

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Protein losing enteropathy refers to any condition of the gastrointestinal tract that results in a net... more...

MalaCards: Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to amyloidosis and arthritis. An important gene associated with Protein-Losing Enteropathy is MPI (mannose phosphate isomerase), and among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Selected targets of C/EBPalpha. The compounds captopril and oxyphenbutazone have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lymph node.

Description from OMIM:47 226300

Aliases & Classifications for Protein-Losing Enteropathy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 47OMIM, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

protein-losing enteropathy 8 10
protein-losing enteropathies 45 61
enteropathy, exudative 8
exudative enteropathy 8


External Ids:

Disease Ontology8 DOID:10611
OMIM47 226300
SNOMED-CT57 66972006, 22542007
MeSH35 D011504

Related Diseases for Protein-Losing Enteropathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Protein-Losing Enteropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis30.9NPPB, CD79A, ALB
2arthritis30.7ALB
3ulcerative colitis30.7ALB
4bronchitis30.5CD79A, SERPINA1
5deficiency anemia30.5ALB, CD79A, MUC16, TF
6acquired immunodeficiency syndrome30.3ALB
7nephritis30.3ALB, CD79A
8vascular disease30.3TF
9vasculitis30.3CD79A, SERPINA1, ALB
10cystic fibrosis30.3ALB, SERPINA1, IGES
11hepatitis c30.3ALB, SERPINA1, TF
12ankylosing spondylitis30.3CD79A, SERPINA1
13adenocarcinoma30.2SERPINA1, MUC16, OXA1L
14systemic lupus erythematosus11.0
15intestinal lymphangiectasia10.8
16eosinophilic enteropathy10.7
17eosinophilic gastroenteritis10.7
18constrictive pericarditis10.7
19n syndrome10.6
20protein c deficiency10.6
21cronkhite-canada syndrome10.5
22congenital hepatic fibrosis10.5
23lymphangiomatosis10.5
24mixed connective tissue disease10.4
25portal hypertension10.4
26giardiasis10.4
27measles10.4
28kaposi's sarcoma10.4
29collagenous colitis10.4
30lymphangiectasis10.4
31graft versus host disease10.4
32protein-deficiency anemia10.4
33atopic dermatitis10.4
34noonan syndrome10.4
35hypoparathyroidism10.4
36gastrointestinal lymphoma10.4
37iron deficiency anemia10.4
38clostridium difficile10.4
39chylous ascites10.4
40tricuspid atresia10.4
41follicular lymphoma10.4
42protein r deficiency10.4
43amyloidosis, secondary10.4
44venous thrombosis10.4
45congenital chronic diarrhea with protein-losing enteropathy10.4
46secondary intestinal lymphangiectasia10.4
47stroke, ischemic10.2
48burns10.2
49rubella10.2
50primary pulmonary hypertension10.2

Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to protein-losing enteropathy

Clinical Features for Protein-Losing Enteropathy

Sources:
47OMIM
See all sources

Clinical features from OMIM:

226300

Drugs & Therapeutics for Protein-Losing Enteropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Protein-Losing Enteropathy

Drug clinical trials:

Search ClinicalTrials for Protein-Losing Enteropathy

Search NIH Clinical Center for Protein-Losing Enteropathy

Search CenterWatch for Protein-Losing Enteropathy

Genetic Tests for Protein-Losing Enteropathy

Anatomical Context for Protein-Losing Enteropathy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Protein-Losing Enteropathy:

33
Skin, Liver, Lymph node, Lung, Bone marrow, Heart, Small intestine, Colon, Thyroid, Breast, T cells, B cells

Animal Models for Protein-Losing Enteropathy or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Protein-Losing Enteropathy

Sources:
51PubMed
See all sources

Articles related to Protein-Losing Enteropathy:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Use of oral budesonide in the management of protein-losing enteropathy due to restrictive cardiomyopathy. (24029379)
2013
2
Progressive mesenteric lymphadenopathy with protein-losing enteropathy; a devastating complication in Gaucher disease. (22227073)
2012
3
Protein-losing enteropathy and premature ovarian failure in a young woman with systemic lupus erythematosus. (22627066)
2012
4
Oral budesonide as a therapy for protein-losing enteropathy in patients having undergone Fontan palliation. (22129195)
2012
5
Protein-losing enteropathy in systemic lupus erythematosus: case report. (23223705)
2012
6
Successful treatment of steroid-refractory systemic lupus erythematosus-associated protein-losing enteropathy using combination therapy with tacrolimus and steroid. (21768173)
2011
7
Protein-losing enteropathy: case illustrations and clinical review. (19789526)
2010
8
New thinking about postoperative hypoalbuminemia: a hypothesis of occult protein-losing enteropathy. (21688758)
2009
9
Magnetic resonance imaging as a new method to diagnose protein losing enteropathy. (19013878)
2008
10
Protein-losing enteropathy in systemic lupus erythematosus: analysis of the clinical features of fifteen patients. (18176138)
2007
11
Resolution of protein-losing enteropathy after successful heart transplantation in an adult patient with arrhythmogenic right ventricular cardiomyopathy (ARVC). (17845940)
2007
12
Results of transcatheter Fontan fenestration to treat protein losing enteropathy. (17323361)
2007
13
Protein-losing enteropathy after fontan operation: investigations into possible pathophysiologic mechanisms. (16863787)
2006
14
A case of protein-losing enteropathy treated with methotrexate in a dog. (16679735)
2006
15
Protein-losing enteropathy in Crohn's disease. (15952090)
2005
16
Traumatic tricuspid regurgitation resulting in protein-losing enteropathy: a case report. (16359069)
2005
17
Severe protein losing enteropathy with intractable diarrhea due to systemic AA amyloidosis, successfully treated with corticosteroid and octreotide. (16076611)
2005
18
Protein-losing enteropathy: radiofrequency fenestration of the atrial septum after failure of transseptal needle puncture. (15043014)
2004
19
Protein-losing enteropathy in patients with fontan operations. (14581789)
2003
20
The utility of Tc-99m dextran in the diagnosis and identification of melanoma metastases responsible for protein-losing enteropathy. (11914661)
2002
21
Congenital intestinal lymphatic hypoplasia presenting as non-immune hydrops in utero, and subsequent neonatal protein-losing enteropathy. (12454588)
2002
22
Immunologic profile of patients with protein-losing enteropathy complicating congenital heart disease. (12530489)
2002
23
Resolution of protein-losing enteropathy with standard high molecular heparin and urokinase after Fontan repair in a patient with tricuspid atresia. (11052284)
2000
24
Protein-losing enteropathy in congestive heart failure: diagnosis by means of a simple method. (10430351)
1999
25
Malignant lymphoma originating in the jejunum of a long-term follow-up case of protein-losing enteropathy. (9260772)
1997
26
Protein-losing enteropathy due to intestinal lymphangiectasia accompanied by mesenteric lymph node fibrosis. (8970198)
1996
27
Protein-losing enteropathy after the Fontan operation. (8800155)
1996
28
Protein-losing enteropathy is associated with Clostridium difficile diarrhea but not with asymptomatic colonization: a prospective, case-control study. (8783689)
1996
29
Protein-losing enteropathy from cap polyposis. (7491082)
1995
30
Management of disseminated intra-abdominal lymphangiomatosis with protein-losing enteropathy and intestinal bleeding. (7481991)
1995
31
Protein-losing enteropathy and cerebral infarction associated with systemic lupus erythematosus]. (8146730)
1994
32
Association of chronic interstitial cystitis, protein-losing enteropathy and paralytic ileus with seronegative systemic lupus erythematosus: case report and review of the literature. (1606774)
1992
33
Constrictive pericarditis without typical haemodynamic changes as a cause of oedema formation due to protein-losing enteropathy. (1782939)
1991
34
Protein-losing enteropathy in systemic lupus erythematosus associated with intestinal lymphangiectasia. (2220736)
1990
35
Intestinal lymphangiectasia with protein losing enteropathy, toxic copper accumulation and hypoparathyroidism. (2344321)
1990
36
Imaging diagnosis of protein-losing enteropathy by 99mTc-labeled serum albumin]. (2290206)
1990
37
Segmental small intestinal allografts. II. Inadequate function with cyclosporine immunosuppression: evidence of a protein-losing enteropathy. (3672607)
1987
38
Administration of intravenous immunoglobulin in two children with hypogammaglobulinaemia due to protein losing enteropathy. (4006307)
1985
39
Protein losing enteropathy due to systemic lupus erythematosus. (6469077)
1984
40
Abnormal fatty acid composition of plasma lipids in patients with protein-losing enteropathy. (7173499)
1982
41
Resolution of longstanding protein-losing enteropathy in a patient with intestinal lymphangiectasia after treatment for malignant lymphoma. (7450403)
1981
42
Protein-losing enteropathy in a boy with systemic lupus erythematosus. (7431171)
1980
43
Protein-losing enteropathy after Fontan operation for tricuspid atresia (imperforate tricuspid valve). (6161437)
1980
44
Incidence of protein-losing enteropathy in primary lymphoedema using chromium-51 chloride technique. (1212583)
1975
45
Protein-losing enteropathy in primary lymphoedema: mesenteric lymphography and gut resection. (4369084)
1974
46
Idiopathic intestinal lymphangiectasis (primary protein-losing enteropathy). Lymphographic verification of enteric and peritoneal leakage of chyle. (4355068)
1973
47
Protein-losing enteropathy caused by intestinal lymphangectasia. (4505439)
1972
48
Protein losing enteropathy with anomalies of intestinal lympatics: diagnosis and treatment. (5579879)
1971
49
Roentgenological findings of protein-losing enteropathy. (5782919)
1969
50
Intestinal lymphangiectasia: a protein-losing enteropathy with hypogammaglobulinemia, lymphocytopenia and impaired homograft rejection. (4168730)
1967

Genetic Variations for Protein-Losing Enteropathy

Expression for genes affiliated with Protein-Losing Enteropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Protein-Losing Enteropathy

Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for genes affiliated with Protein-Losing Enteropathy

Sources:
54Reactome, 12EMD Millipore
See all sources

Pathways related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8ALG6, MPI
29.7ALB, TF
3
Hide members
9.2ALB, SERPINA1, TF

Compounds for genes affiliated with Protein-Losing Enteropathy

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB
See all sources

Compounds related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1captopril45 29 50 60 1114.4CD79A
2oxyphenbutazone45 1111.1OXA1L
3Bismuth Subsalicylate1110.0TF, ALB
4kp-10194510.0TF, ALB
5dansylsarcosine4510.0OXA1L, ALB
6rhsa459.9OXA1L, ALB
7tolmetin glucuronide459.9ALB, OXA1L
8azapropazone45 1110.9OXA1L, ALB
9pirprofen459.9OXA1L, ALB
10cellulose acetate459.9MPI, CD79A, ALB
11kebuzone459.9OXA1L, ALB
12sodium octanoate459.9OXA1L, ALB
13acetyldigitoxin45 1110.9OXA1L, ALB
14hhpa459.9ALB, OXA1L
15eprex459.8ALB, OXA1L
16dansylamide45 1110.8ALB, OXA1L
17ramipril45 1110.8CD79A, NPPB, ALB
18sulfisoxazole45 60 50 1112.8OXA1L, ALB
19(s)-ketoprofen459.8ALB, OXA1L
20polyvinylpyrrolidone459.8ALB, OXA1L
21fenoprofen29 45 1111.7ALB, OXA1L
22cyclosarin459.7ALB, OXA1L
23sinapic acid459.7OXA1L, TF
24piroxicam45 1110.6OXA1L, CD79A, ALB
25warfarin45 50 11 2412.6CD79A, OXA1L
26enterotoxin459.6CD79A, NPPB, IGES
27indoxyl sulfate459.6OXA1L, ALB
28phenylbutazone45 1110.5ALB, SERPINA1, OXA1L
29furosemide45 50 60 29 11 2414.5OXA1L, NPPB, ALB
30suprofen45 1110.5OXA1L, ALB, TF
31phenytoin45 50 29 1112.4OXA1L, CD79A, ALB
32dtpa459.4ALB, TF, OXA1L
33tacrolimus45 50 1111.2NPPB, TF, CD79A, ALB
34vitamin b12459.2TF, ALB, CD79A
35palmitate459.1DGAT1, TF, OXA1L, ALB
36glutaraldehyde459.1ALB, TF, OXA1L, CD79A
37polyethylene glycol459.1ALB, CD79A, OXA1L, TF
38indomethacin45 60 29 1112.1DGAT1, NPPB, CD79A, ALB
39ascorbic acid45 249.9ALB, SERPINA1, CD79A, TF
40aspirin45 50 29 2411.9NPPB, IGES, OXA1L, CD79A
41bicarbonate458.9ALB, MUC16, TF, NPPB
42salicylic acid45 299.8OXA1L, SERPINA1, ALB
43histamine45 29 2410.8ALB, CD79A, IGES, TF, NPPB
44thyroxine45 249.7CD79A, ALB, OXA1L, TF, NPPB
45iron45 249.7MUC16, SERPINA1, NPPB, TF
46prednisolone45 29 1110.5TF, MUC16, CD79A, ALB, NPPB
47glucose458.2ALB, SERPINA1, NPPB, MUC16, DGAT1, MPI
48creatinine458.0TF, MUC16, NPPB, CD79A, SERPINA1, ALB
49lactate458.0CD79A, ALB, TF, IGES, NPPB, MUC16
50fibrinogen457.8CD79A, MUC16, OXA1L, TF, SERPINA1, ALB

GO Terms for genes affiliated with Protein-Losing Enteropathy

Sources:
16Gene Ontology
See all sources

Biological processes related to Protein-Losing Enteropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dolichol-linked oligosaccharide biosynthetic processGO:0064889.8MPI, ALG6
2platelet degranulationGO:0025769.2ALB, SERPINA1, TF
3post-translational protein modificationGO:0436878.9MUC16, ALG6, MPI
4platelet activationGO:0301688.9SERPINA1, TF, ALB

Products for genes affiliated with Protein-Losing Enteropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Protein-Losing Enteropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet