MCID: PRT019
MIFTS: 42

Protein-Losing Enteropathy malady

Category: Gastrointestinal diseases

Aliases & Classifications for Protein-Losing Enteropathy

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Aliases & Descriptions for Protein-Losing Enteropathy:

Name: Protein-Losing Enteropathy 11 27 13
Protein-Losing Enteropathies 50 39 68
 
Enteropathy, Exudative 11
Exudative Enteropathy 11

Characteristics:


Classifications:



External Ids:

Disease Ontology11 DOID:10611
SNOMED-CT62 22542007, 66972006
MeSH39 D011504

Summaries for Protein-Losing Enteropathy

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Wikipedia:71 Protein losing enteropathy refers to any condition of the gastrointestinal tract (e.g. damage to the gut... more...

MalaCards based summary: Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to congenital disorder of glycosylation, type ib and congenital diarrhea 7 with exudative enteropathy, and has symptoms including edema, clubbing and growth delay. An important gene associated with Protein-Losing Enteropathy is ALB (Albumin), and among its related pathways are N-Glycan biosynthesis and Synthesis of substrates in N-glycan biosythesis. Affiliated tissues include heart, small intestine and liver.

Related Diseases for Protein-Losing Enteropathy

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Diseases related to Protein-Losing Enteropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1congenital disorder of glycosylation, type ib12.0
2congenital diarrhea 7 with exudative enteropathy11.7
3lymphangiectasis11.3
4primary intestinal lymphangiectasia11.3
5diarrhea 711.2
6congenital disorder of glycosylation, type ic11.0
7lupus erythematosus10.6
8systemic lupus erythematosus10.6
9lymphoma10.4
10pericarditis10.3
11colitis10.3
12constrictive pericarditis10.3
13heart disease10.3
14gastroenteritis10.3
15eosinophilic gastroenteritis10.3
16amyloidosis10.2
17atopic dermatitis 610.2ALB, CD79A
18colloid adenoma10.2ALB, CD79A
19schneiderian carcinoma10.2ALB, CD79A
20striatonigral degeneration10.2ALB, CD79A
21hepatitis10.2
22diarrhea10.2
23infertility due to extratesticular cause10.2ALB, CD79A
24congenital nystagmus10.2ALB, CD79A
25male genital organ stricture10.2ALB, CD79A
26tarp syndrome10.2ALB, CD79A
27coronary artery dissection, spontaneous10.2ALB, CD79A
28ciliary discoordination, due to random ciliary orientation10.2ALB, CD79A
29angiokeratoma10.2ALB, CD79A
30chromosome 18 pericentric inversion10.2ALB, SERPINA1
31acrofacial dysostosis, patagonia type10.2ALB, SERPINA1
32idiopathic peripheral autonomic neuropathy10.2ALB, SERPINA1
33venezuelan equine encephalitis10.2ALB, CD79A
34porencephaly, cerebellar hypoplasia, and internal malformations10.2ALB, SERPINA1
35connective tissue disease10.2
36dermatomycosis10.2ALB, CD79A
37bile duct cystadenocarcinoma10.2ALB, SERPINA1
38mikulicz disease10.2ALB, CD79A
39malignant hyperthermia susceptibility 110.2ALB, CD79A
40hemiplegia10.2ALB, CD79A
41spastic entropion10.2ALB, CD79A
42klinefelter's syndrome10.2ALB, SERPINA1
43vulvar sarcoma10.2ALB, SERPINA1
44bronchiolitis10.2ALB, CD79A
45autonomic peripheral neuropathy10.2ALB, CD79A
46bladder sarcoma10.1ALB, CD79A
47homocystinuria10.1CD79A, SERPINA1
48crohn's disease10.1
49collagenous colitis10.1
50thrombosis10.1

Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to protein-losing enteropathy

Symptoms & Phenotypes for Protein-Losing Enteropathy

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Human phenotypes related to Protein-Losing Enteropathy:

 64 (show all 10)
id Description HPO Frequency HPO Source Accession
1 edema64 HP:0000969
2 clubbing64 HP:0001217
3 growth delay64 HP:0001510
4 ascites64 HP:0001541
5 iron deficiency anemia64 HP:0001891
6 diarrhea64 HP:0002014
7 abdominal pain64 HP:0002027
8 abnormality of the intestine64 HP:0002242
9 budd-chiari syndrome64 HP:0002639
10 hypoproteinemia64 HP:0003075

Drugs & Therapeutics for Protein-Losing Enteropathy

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Drugs for Protein-Losing Enteropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Heparinapproved, investigationalPhase 18489005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
2calcium heparinPhase 1848
3
Substance Pinvestigational24933507-63-044359816
Synonyms:
 
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
4Vasodilator Agents3543
5Vasoactive intestinal peptide640077-57-4
6Neuroprotective Agents1716
7Gastrointestinal Agents8402
8neurokinin A253
9Protective Agents7443

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pilot/Ph I Safety and Efficacy of ODSH in Protein Losing Enteropathy Secondary to Single Ventricle Palliative SurgeryTerminatedNCT01161641Phase 1
2Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle PhysiologyCompletedNCT01563757
3International Lymphatic Disease and Lymphedema RegistryRecruitingNCT01336790

Search NIH Clinical Center for Protein-Losing Enteropathy


Cochrane evidence based reviews: protein-losing enteropathies

Genetic Tests for Protein-Losing Enteropathy

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Genetic tests related to Protein-Losing Enteropathy:

id Genetic test Affiliating Genes
1 Enteropathy, Protein-Losing27

Anatomical Context for Protein-Losing Enteropathy

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MalaCards organs/tissues related to Protein-Losing Enteropathy:

36
Heart, Small intestine, Liver, Colon, Bone, Testes, Breast

Publications for Protein-Losing Enteropathy

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Articles related to Protein-Losing Enteropathy:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Protein-losing Enteropathy Caused by Intestinal or Colonic Lymphangiectasia Complicated by Sporadic Lymphangioleiomyomatosis: A Report of Two Cases. (28420844)
2017
2
Massive Mesenteric Lymphadenopathy Causing Protein-losing Enteropathy in Gaucher Disease. (28060125)
2017
3
Retrospective evaluation of the administration of 25% human albumin to dogs with protein-losing enteropathy: 21 cases (2003-2013). (27159733)
2016
4
Successful therapy for protein-losing enteropathy caused by chronic neuronopathic Gaucher disease. (27014572)
2016
5
Protein-losing enteropathy in a patient with familial adenomatous polyposis and advanced colon cancer. (27170298)
2016
6
Protein-losing enteropathy and erythema caused by egg allergy in a breast-fed infant. (26818703)
2016
7
Protein-losing enteropathy in camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome. (27224999)
2016
8
Protein-losing enteropathy with entestinal lymphangiectasia in skeletal dysplasia with Lys650Met mutation. (27214123)
2016
9
Everolimus for Primary Intestinal Lymphangiectasia With Protein-Losing Enteropathy. (26908672)
2016
10
Hypoadrenocorticism mimicking protein-losing enteropathy in 4 dogs. (27429465)
2016
11
Thoracic Duct Decompression for Protein-Losing Enteropathy in Failing Fontan Circulation. (27211948)
2016
12
Hypothyroidism and protein-losing enteropathy: A case report. (26705734)
2016
13
Marginal Zone Lymphoma Complicated by Protein Losing Enteropathy. (27891267)
2016
14
Constrictive Pericarditis and Protein-Losing Enteropathy: Is Extremely Severe Hypoalbuminemia Reversible by Pericardiectomy? (27864304)
2016
15
Towards a proposal for a universal diagnostic definition of protein-losing enteropathy in Fontan patients: a systematic review. (27033590)
2016
16
Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations. (26883093)
2016
17
Effectiveness of High-dose Spironolactone Therapy in a Patient with Recurrent Protein-losing Enteropathy after the Fontan Procedure. (27301514)
2016
18
Original Surgical Procedure for the Treatment of Protein-Losing Enteropathy in Fontan Patients: Report of Two Midterm Successes. (27550969)
2016
19
Protein Losing Enteropathy After Cardiac Transplantation Successfully Treated by Stent Implantation. (27549730)
2016
20
Neonatal diabetes and protein losing enteropathy: a case report. (27098067)
2016
21
Thromboembolism in Dogs with Protein-Losing Enteropathy with Non-Neoplastic Chronic Small Intestinal Disease. (27841681)
2016
22
Protein-losing enteropathy in an HIV-infected pediatric patient with previous disseminated Mycobacterium genavense infection. (25849838)
2015
23
Gastrointestinal: Endoscopic findings of collagenous gastroenterocolitis with protein-losing enteropathy. (25916480)
2015
24
BehAset disease and protein-losing enteropathy due to intestinal lymphangiectasia. (25661471)
2015
25
Protein-losing enteropathy as a rare complication of the ketogenic diet. (25724370)
2015
26
Fontan-associated protein-losing enteropathy and plastic bronchitis. (25661406)
2015
27
Protein-losing enteropathy associated with refractory systemic lupus erythematosus with a good response to rituximab. (25818375)
2015
28
Seizures Associated With Hypocalcemia in a Yorkshire Terrier With Protein-Losing Enteropathy. (26535456)
2015
29
Profound Reversible Hypogammaglobulinemia Caused by Celiac Disease in the Absence of Protein Losing Enteropathy. (26318181)
2015
30
Evaluation of serum biochemical marker concentrations and survival time in dogs with protein-losing enteropathy. (25517330)
2015
31
Mutations in Plasmalemma Vesicle Associated Protein Result in Sieving Protein-Losing Enteropathy Characterized by Hypoproteinemia, Hypoalbuminemia, and Hypertriglyceridemia. (26207260)
2015
32
Protein-losing enteropathy in a patient on ketogenic diet for limbic encephalitis--treatment effect or underlying pathology? (25979660)
2015
33
Transnodal lymphangiography and post-CT for protein-losing enteropathy in Noonan syndrome. (25636017)
2015
34
Protein-losing enteropathy cured by resection of adenomatous goiter: report of a case. (25845937)
2015
35
Plasmalemma Vesicle Associated Protein Truncation Causes Lethal Protein-Losing Enteropathy in Humans. (26225357)
2015
36
Prognostic factors in dogs with protein-losing enteropathy. (26025135)
2015
37
Fontan-associated protein-losing enteropathy and heart transplant: A Pediatric Heart Transplant Study analysis. (25987313)
2015
38
Photo quiz. Diarrhea, anasarca, and severe hypoalbuminemia in an AIDS patient. Diagnosis: AIDS-related visceral Kaposi sarcoma (KS) with protein-losing enteropathy (PLE). (25801550)
2015
39
Collagenous Colitis Associated with Protein-losing Enteropathy. (26568022)
2015
40
Immune Abnormalities in Fontan Protein-Losing Enteropathy: A Case-Control Study. (26009017)
2015
41
Successful diuretics treatment of protein-losing enteropathy in Noonan syndrome. (25868959)
2015
42
A Novel SMAD4 Mutation Causing Severe Juvenile Polyposis Syndrome with Protein Losing Enteropathy, Immunodeficiency, and Hereditary Haemorrhagic Telangiectasia. (25705527)
2015
43
Gastrointestinal ALI_ amyloidosis presenting as protein-losing enteropathy correctly diagnosed by immunohistochemistry using amyloid-type-specific antibodies. (26724341)
2015
44
Protein-losing enteropathy in inflammatory bowel diseases. (26446687)
2015
45
Disseminated cytomegalovirus infection and protein losing enteropathy as presenting feature of pediatric patient with Crohn's disease. (25866735)
2015
46
Factors related to outcomes in lupus-related protein-losing enteropathy. (26552467)
2015
47
Case report: protein-losing enteropathy caused by Mesocestoides vogae (syn. M. corti) in a dog. (25129334)
2014
48
Polypectomy to eradicate cap polyposis with protein-losing enteropathy. (25287098)
2014
49
Transjugular melody valve placement in a small child with protein losing enteropathy. (24659117)
2014
50
Collagenous colitis associated with protein losing enteropathy in a toddler. (25221677)
2014

Variations for Protein-Losing Enteropathy

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Expression for genes affiliated with Protein-Losing Enteropathy

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Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for genes affiliated with Protein-Losing Enteropathy

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GO Terms for genes affiliated with Protein-Losing Enteropathy

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Cellular components related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6ALB, SERPINA1
2endoplasmic reticulumGO:00057838.2ALB, ALG6, ALG8, ANTXR2, SERPINA1

Biological processes related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dolichol-linked oligosaccharide biosynthetic processGO:00064889.8ALG6, ALG8
2oligosaccharide-lipid intermediate biosynthetic processGO:00064909.8ALG6, ALG8
3protein glycosylationGO:00064869.3ALG6, ALG8, MPI
4protein N-linked glycosylationGO:00064879.2ALG6, ALG8

Molecular functions related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activityGO:00422819.7ALG6, ALG8
2dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activityGO:00045839.7ALG6, ALG8
3transferase activity, transferring hexosyl groupsGO:00167589.2ALG6, ALG8

Sources for Protein-Losing Enteropathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet