MCID: PRT019
MIFTS: 42

Protein-Losing Enteropathy malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Protein-Losing Enteropathy

Aliases & Descriptions for Protein-Losing Enteropathy:

Name: Protein-Losing Enteropathy 12 29 14
Protein-Losing Enteropathies 52 42 69
Enteropathy, Exudative 12
Exudative Enteropathy 12

Characteristics:

HPO:

32
protein-losing enteropathy:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:10611
MeSH 42 D011504
SNOMED-CT 64 22542007 66972006
UMLS 69 C0033680

Summaries for Protein-Losing Enteropathy

MalaCards based summary : Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to congenital disorder of glycosylation, type ib and congenital diarrhea 7 with exudative enteropathy, and has symptoms including edema, abdominal pain and diarrhea. An important gene associated with Protein-Losing Enteropathy is ALB (Albumin), and among its related pathways/superpathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. The drugs Heparin and calcium heparin have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and liver.

Wikipedia : 71 Protein losing enteropathy refers to any condition of the gastrointestinal tract (e.g. damage to the gut... more...

Related Diseases for Protein-Losing Enteropathy

Diseases related to Protein-Losing Enteropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
id Related Disease Score Top Affiliating Genes
1 congenital disorder of glycosylation, type ib 12.0
2 congenital diarrhea 7 with exudative enteropathy 11.7
3 lymphangiectasis 11.3
4 primary intestinal lymphangiectasia 11.3
5 diarrhea 7 11.2
6 congenital disorder of glycosylation, type ic 11.0
7 lupus erythematosus 10.6
8 systemic lupus erythematosus 10.6
9 lymphoma 10.4
10 pericarditis 10.3
11 colitis 10.3
12 constrictive pericarditis 10.3
13 gastroenteritis 10.3
14 eosinophilic gastroenteritis 10.3
15 heart disease 10.3
16 amyloidosis 10.2
17 atopic dermatitis 6 10.2 ALB CD79A
18 colloid adenoma 10.2 ALB CD79A
19 schneiderian carcinoma 10.2 ALB CD79A
20 striatonigral degeneration 10.2 ALB CD79A
21 diarrhea 10.2
22 hepatitis 10.2
23 infertility due to extratesticular cause 10.2 ALB CD79A
24 congenital nystagmus 10.2 ALB CD79A
25 male genital organ stricture 10.2 ALB CD79A
26 tarp syndrome 10.2 ALB CD79A
27 coronary artery dissection, spontaneous 10.2 ALB CD79A
28 ciliary discoordination, due to random ciliary orientation 10.2 ALB CD79A
29 angiokeratoma 10.2 ALB CD79A
30 chromosome 18 pericentric inversion 10.2 ALB SERPINA1
31 acrofacial dysostosis, patagonia type 10.2 ALB SERPINA1
32 idiopathic peripheral autonomic neuropathy 10.2 ALB SERPINA1
33 venezuelan equine encephalitis 10.2 ALB CD79A
34 porencephaly, cerebellar hypoplasia, and internal malformations 10.2 ALB SERPINA1
35 connective tissue disease 10.2
36 dermatomycosis 10.2 ALB CD79A
37 bile duct cystadenocarcinoma 10.2 ALB SERPINA1
38 mikulicz disease 10.2 ALB CD79A
39 malignant hyperthermia susceptibility 1 10.2 ALB CD79A
40 hemiplegia 10.2 ALB CD79A
41 spastic entropion 10.2 ALB CD79A
42 klinefelter's syndrome 10.2 ALB SERPINA1
43 vulvar sarcoma 10.2 ALB SERPINA1
44 bronchiolitis 10.2 ALB CD79A
45 autonomic peripheral neuropathy 10.2 ALB CD79A
46 bladder sarcoma 10.1 ALB CD79A
47 homocystinuria 10.1 CD79A SERPINA1
48 purpura 10.1
49 thrombosis 10.1
50 crohn's disease 10.1

Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to Protein-Losing Enteropathy

Symptoms & Phenotypes for Protein-Losing Enteropathy

Human phenotypes related to Protein-Losing Enteropathy:

32 (show all 10)
id Description HPO Frequency HPO Source Accession
1 edema 32 HP:0000969
2 abdominal pain 32 HP:0002027
3 diarrhea 32 HP:0002014
4 clubbing 32 HP:0001217
5 ascites 32 HP:0001541
6 growth delay 32 HP:0001510
7 iron deficiency anemia 32 HP:0001891
8 abnormality of the intestine 32 HP:0002242
9 hypoproteinemia 32 HP:0003075
10 budd-chiari syndrome 32 HP:0002639

Drugs & Therapeutics for Protein-Losing Enteropathy

Drugs for Protein-Losing Enteropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 1 9005-49-6 772 46507594
2 calcium heparin Phase 1
3
Substance P Investigational 33507-63-0 44359816
4 Gastrointestinal Agents
5 neurokinin A
6 Neuroprotective Agents
7 Protective Agents
8 Vasoactive intestinal peptide 40077-57-4
9 Vasodilator Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Pilot/Ph I Safety and Efficacy of ODSH in Protein Losing Enteropathy Secondary to Single Ventricle Palliative Surgery Terminated NCT01161641 Phase 1
2 Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology Completed NCT01563757
3 International Lymphatic Disease and Lymphedema Registry Recruiting NCT01336790

Search NIH Clinical Center for Protein-Losing Enteropathy

Cochrane evidence based reviews: protein-losing enteropathies

Genetic Tests for Protein-Losing Enteropathy

Genetic tests related to Protein-Losing Enteropathy:

id Genetic test Affiliating Genes
1 Enteropathy, Protein-Losing 29

Anatomical Context for Protein-Losing Enteropathy

MalaCards organs/tissues related to Protein-Losing Enteropathy:

39
Heart, Small Intestine, Liver, Colon, Testes, Bone, Breast

Publications for Protein-Losing Enteropathy

Articles related to Protein-Losing Enteropathy:

(show top 50) (show all 560)
id Title Authors Year
1
Protein-losing Enteropathy Caused by Intestinal or Colonic Lymphangiectasia Complicated by Sporadic Lymphangioleiomyomatosis: A Report of Two Cases. ( 28420844 )
2017
2
Massive Mesenteric Lymphadenopathy Causing Protein-losing Enteropathy in Gaucher Disease. ( 28060125 )
2017
3
Retrospective evaluation of the administration of 25% human albumin to dogs with protein-losing enteropathy: 21 cases (2003-2013). ( 27159733 )
2016
4
Successful therapy for protein-losing enteropathy caused by chronic neuronopathic Gaucher disease. ( 27014572 )
2016
5
Protein-losing enteropathy in a patient with familial adenomatous polyposis and advanced colon cancer. ( 27170298 )
2016
6
Protein-losing enteropathy and erythema caused by egg allergy in a breast-fed infant. ( 26818703 )
2016
7
Protein-losing enteropathy in camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome. ( 27224999 )
2016
8
Protein-losing enteropathy with entestinal lymphangiectasia in skeletal dysplasia with Lys650Met mutation. ( 27214123 )
2016
9
Everolimus for Primary Intestinal Lymphangiectasia With Protein-Losing Enteropathy. ( 26908672 )
2016
10
Hypoadrenocorticism mimicking protein-losing enteropathy in 4 dogs. ( 27429465 )
2016
11
Thoracic Duct Decompression for Protein-Losing Enteropathy in Failing Fontan Circulation. ( 27211948 )
2016
12
Hypothyroidism and protein-losing enteropathy: A case report. ( 26705734 )
2016
13
Marginal Zone Lymphoma Complicated by Protein Losing Enteropathy. ( 27891267 )
2016
14
Constrictive Pericarditis and Protein-Losing Enteropathy: Is Extremely Severe Hypoalbuminemia Reversible by Pericardiectomy? ( 27864304 )
2016
15
Towards a proposal for a universal diagnostic definition of protein-losing enteropathy in Fontan patients: a systematic review. ( 27033590 )
2016
16
Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations. ( 26883093 )
2016
17
Effectiveness of High-dose Spironolactone Therapy in a Patient with Recurrent Protein-losing Enteropathy after the Fontan Procedure. ( 27301514 )
2016
18
Original Surgical Procedure for the Treatment of Protein-Losing Enteropathy in Fontan Patients: Report of Two Midterm Successes. ( 27550969 )
2016
19
Protein Losing Enteropathy After Cardiac Transplantation Successfully Treated by Stent Implantation. ( 27549730 )
2016
20
Neonatal diabetes and protein losing enteropathy: a case report. ( 27098067 )
2016
21
Thromboembolism in Dogs with Protein-Losing Enteropathy with Non-Neoplastic Chronic Small Intestinal Disease. ( 27841681 )
2016
22
Protein-losing enteropathy in an HIV-infected pediatric patient with previous disseminated Mycobacterium genavense infection. ( 25849838 )
2015
23
Gastrointestinal: Endoscopic findings of collagenous gastroenterocolitis with protein-losing enteropathy. ( 25916480 )
2015
24
BehAset disease and protein-losing enteropathy due to intestinal lymphangiectasia. ( 25661471 )
2015
25
Protein-losing enteropathy as a rare complication of the ketogenic diet. ( 25724370 )
2015
26
Fontan-associated protein-losing enteropathy and plastic bronchitis. ( 25661406 )
2015
27
Protein-losing enteropathy associated with refractory systemic lupus erythematosus with a good response to rituximab. ( 25818375 )
2015
28
Seizures Associated With Hypocalcemia in a Yorkshire Terrier With Protein-Losing Enteropathy. ( 26535456 )
2015
29
Profound Reversible Hypogammaglobulinemia Caused by Celiac Disease in the Absence of Protein Losing Enteropathy. ( 26318181 )
2015
30
Evaluation of serum biochemical marker concentrations and survival time in dogs with protein-losing enteropathy. ( 25517330 )
2015
31
Mutations in Plasmalemma Vesicle Associated Protein Result in Sieving Protein-Losing Enteropathy Characterized by Hypoproteinemia, Hypoalbuminemia, and Hypertriglyceridemia. ( 26207260 )
2015
32
Protein-losing enteropathy in a patient on ketogenic diet for limbic encephalitis--treatment effect or underlying pathology? ( 25979660 )
2015
33
Transnodal lymphangiography and post-CT for protein-losing enteropathy in Noonan syndrome. ( 25636017 )
2015
34
Protein-losing enteropathy cured by resection of adenomatous goiter: report of a case. ( 25845937 )
2015
35
Plasmalemma Vesicle Associated Protein Truncation Causes Lethal Protein-Losing Enteropathy in Humans. ( 26225357 )
2015
36
Prognostic factors in dogs with protein-losing enteropathy. ( 26025135 )
2015
37
Fontan-associated protein-losing enteropathy and heart transplant: A Pediatric Heart Transplant Study analysis. ( 25987313 )
2015
38
Photo quiz. Diarrhea, anasarca, and severe hypoalbuminemia in an AIDS patient. Diagnosis: AIDS-related visceral Kaposi sarcoma (KS) with protein-losing enteropathy (PLE). ( 25801550 )
2015
39
Collagenous Colitis Associated with Protein-losing Enteropathy. ( 26568022 )
2015
40
Immune Abnormalities in Fontan Protein-Losing Enteropathy: A Case-Control Study. ( 26009017 )
2015
41
Successful diuretics treatment of protein-losing enteropathy in Noonan syndrome. ( 25868959 )
2015
42
A Novel SMAD4 Mutation Causing Severe Juvenile Polyposis Syndrome with Protein Losing Enteropathy, Immunodeficiency, and Hereditary Haemorrhagic Telangiectasia. ( 25705527 )
2015
43
Gastrointestinal ALI_ amyloidosis presenting as protein-losing enteropathy correctly diagnosed by immunohistochemistry using amyloid-type-specific antibodies. ( 26724341 )
2015
44
Protein-losing enteropathy in inflammatory bowel diseases. ( 26446687 )
2015
45
Disseminated cytomegalovirus infection and protein losing enteropathy as presenting feature of pediatric patient with Crohn's disease. ( 25866735 )
2015
46
Factors related to outcomes in lupus-related protein-losing enteropathy. ( 26552467 )
2015
47
Case report: protein-losing enteropathy caused by Mesocestoides vogae (syn. M. corti) in a dog. ( 25129334 )
2014
48
Polypectomy to eradicate cap polyposis with protein-losing enteropathy. ( 25287098 )
2014
49
Transjugular melody valve placement in a small child with protein losing enteropathy. ( 24659117 )
2014
50
Collagenous colitis associated with protein losing enteropathy in a toddler. ( 25221677 )
2014

Variations for Protein-Losing Enteropathy

Expression for Protein-Losing Enteropathy

Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for Protein-Losing Enteropathy

GO Terms for Protein-Losing Enteropathy

Cellular components related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.02 ALB ALG6 ALG8 ANTXR2 SERPINA1
2 platelet alpha granule lumen GO:0031093 8.96 ALB SERPINA1

Biological processes related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein glycosylation GO:0006486 9.33 ALG6 ALG8 MPI
2 protein N-linked glycosylation GO:0006487 9.26 ALG6 ALG8
3 dolichol-linked oligosaccharide biosynthetic process GO:0006488 8.96 ALG6 ALG8
4 oligosaccharide-lipid intermediate biosynthetic process GO:0006490 8.62 ALG6 ALG8

Molecular functions related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring hexosyl groups GO:0016758 9.16 ALG6 ALG8
2 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0004583 8.96 ALG6 ALG8
3 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0042281 8.62 ALG6 ALG8

Sources for Protein-Losing Enteropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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