MCID: PRT019
MIFTS: 36

Protein-Losing Enteropathy

Categories: Gastrointestinal diseases

Aliases & Classifications for Protein-Losing Enteropathy

MalaCards integrated aliases for Protein-Losing Enteropathy:

Name: Protein-Losing Enteropathy 12 14
Protein-Losing Enteropathies 52 42 69
Enteropathy, Protein-Losing 29
Enteropathy, Exudative 12
Exudative Enteropathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10611
MeSH 42 D011504
SNOMED-CT 64 22542007 66972006
UMLS 69 C0033680

Summaries for Protein-Losing Enteropathy

MalaCards based summary : Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to lymphoma and complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy. An important gene associated with Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)), and among its related pathways/superpathways is Transport to the Golgi and subsequent modification. The drugs Heparin and calcium heparin have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and liver.

Wikipedia : 72 Protein losing enteropathy refers to any condition of the gastrointestinal tract (e.g. damage to the gut... more...

Related Diseases for Protein-Losing Enteropathy

Diseases related to Protein-Losing Enteropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
id Related Disease Score Top Affiliating Genes
1 lymphoma 30.7 ALB CD79A
2 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 12.4
3 congenital disorder of glycosylation, type ib 12.0
4 congenital diarrhea 7 with exudative enteropathy 11.7
5 lymphangiectasis 11.3
6 primary intestinal lymphangiectasia 11.3
7 diarrhea 7 11.2
8 congenital disorder of glycosylation, type ic 11.0
9 lupus erythematosus 10.6
10 systemic lupus erythematosus 10.6
11 maturity-onset diabetes of the young, type 14 10.4 ALG6 MPI
12 atopic dermatitis 5 10.3 ALB CD79A
13 microinvasive cervical squamous cell carcinoma 10.3 ALB CD79A
14 ovary transitional cell carcinoma 10.3 ALB CD79A
15 pericarditis 10.3
16 non-congenital cyst of kidney 10.3 ALB CD79A
17 infertility due to extratesticular cause 10.3 ALB CD79A
18 male genital organ stricture 10.3 ALB CD79A
19 colitis 10.3
20 heart disease 10.3
21 constrictive pericarditis 10.3
22 adie pupil 10.3 ALB CD79A
23 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.3 ALB CD79A
24 immune-complex glomerulonephritis 10.3 ALB CD79A
25 tarp syndrome 10.3 ALB CD79A
26 adrenal gland disease 10.3 ALB CD79A
27 eosinophilic gastroenteritis 10.3
28 gastroenteritis 10.3
29 diarrhea 10.3
30 dermatomycosis 10.3 ALB CD79A
31 pyrimidine metabolic disorder 10.3 ALB CD79A
32 toxic myocarditis 10.3 ALB CD79A
33 bladder diverticulum 10.3 ALB CD79A
34 amyloidosis 10.3
35 autoimmune disease of cardiovascular system 10.2 ALB CD79A
36 spastic monoplegia 10.2 ALB CD79A
37 spastic entropion 10.2 ALB CD79A
38 hepatitis 10.2
39 thrombosis 10.2
40 bladder sarcoma 10.2 ALB CD79A
41 aleutian mink disease 10.2 ALB CD79A
42 late yaws 10.2 ALB CD79A
43 mikulicz disease 10.2 ALB CD79A
44 connective tissue disease 10.2
45 crohn's disease 10.2
46 choreatic disease 10.2 ALB CD79A
47 carcinoma arising in nasal papillomatosis 10.2 ALB CD79A
48 cardiomyopathy, hypertrophic, 3 10.2 MPI SERPINA1
49 collagenous colitis 10.1
50 purpura 10.1

Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to Protein-Losing Enteropathy

Symptoms & Phenotypes for Protein-Losing Enteropathy

Drugs & Therapeutics for Protein-Losing Enteropathy

Drugs for Protein-Losing Enteropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 1 9005-49-6 772 46507594
2 calcium heparin Phase 1
3
Substance P Investigational 33507-63-0 44359816
4 Gastrointestinal Agents
5 neurokinin A
6 Neuroprotective Agents
7 Protective Agents
8 Vasoactive intestinal peptide 40077-57-4
9 Vasodilator Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Pilot/Ph I Safety and Efficacy of ODSH in Protein Losing Enteropathy Secondary to Single Ventricle Palliative Surgery Terminated NCT01161641 Phase 1 ODSH at 0.125 mg/kg/h;ODSH at 0.375 mg/kg/h;ODSH at 0.250 mg/kg/h
2 Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology Completed NCT01563757
3 International Lymphatic Disease and Lymphedema Registry Recruiting NCT01336790

Search NIH Clinical Center for Protein-Losing Enteropathy

Cochrane evidence based reviews: protein-losing enteropathies

Genetic Tests for Protein-Losing Enteropathy

Genetic tests related to Protein-Losing Enteropathy:

id Genetic test Affiliating Genes
1 Enteropathy, Protein-Losing 29

Anatomical Context for Protein-Losing Enteropathy

MalaCards organs/tissues related to Protein-Losing Enteropathy:

39
Heart, Small Intestine, Liver, Colon, Testes, Bone, T Cells

Publications for Protein-Losing Enteropathy

Articles related to Protein-Losing Enteropathy:

(show top 50) (show all 580)
id Title Authors Year
1
Protein-Losing Enteropathy as a Complication of the Ketogenic Diet. ( 28541008 )
2017
2
Once More Unto the Breach: A New Treatment Paradigm for Protein-Losing Enteropathy. ( 28619194 )
2017
3
Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states. ( 28761367 )
2017
4
Bilateral Serous Macular Elevation Associated with Lupus Protein-losing Enteropathy. ( 28540024 )
2017
5
CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis. ( 28657829 )
2017
6
Nonsteroidal anti-inflammatory drug-induced protein-losing enteropathy: a great masquerade of Crohn's disease. ( 28554654 )
2017
7
Selenium status and fungi in the protein-losing enteropathy of persistent diarrhea. ( 28625042 )
2017
8
Cytomegalovirus-associated protein-losing enteropathy in a healthy man. ( 28802763 )
2017
9
Loss of CD55 in Eculizumab-Responsive Protein-Losing Enteropathy. ( 28657861 )
2017
10
Gastrointestinal haemorrhage due to lymphangiectasia caused by protein-losing enteropathy in the Fontan circulation. ( 28651669 )
2017
11
Congenital Diarrhea from DGAT1 Mutation Leading to Electrolyte Derangements, Protein-Losing Enteropathy, and Rickets. ( 28937539 )
2017
12
A case of protein-losing enteropathy caused by sclerosing mesenteritis diagnosed with capsule endoscopy and double-balloon endoscopy. ( 28664384 )
2017
13
Protein-losing enteropathy resolved after ventral abdominal hernia repair. ( 28743538 )
2017
14
Multiple small intestinal ulcers associated with protein-losing enteropathy secondary to cholesterol crystal embolism:a case report. ( 28781354 )
2017
15
An Early Glenn Operation May be Associated with the Later Occurrence of Protein-Losing Enteropathy in Fontan Patients : Association of Early Glenn and Failing Fontan. ( 28534240 )
2017
16
Massive Mesenteric Lymphadenopathy Causing Protein-losing Enteropathy in Gaucher Disease. ( 28060125 )
2017
17
Protein-losing Enteropathy Caused by Intestinal or Colonic Lymphangiectasia Complicated by Sporadic Lymphangioleiomyomatosis: A Report of Two Cases. ( 28420844 )
2017
18
Protein-Losing Enteropathy in Patients With Congenital Heart Disease. ( 28619193 )
2017
19
Investigation of the Influence of Protein-Losing Enteropathy on Monoclonal Antibody Pharmacokinetics in Mice. ( 28849396 )
2017
20
Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature. ( 28375198 )
2017
21
Protein-losing Enteropathy Caused by Spontaneous Reduction of Intussusception with Meckel's Diverticulum. ( 28413865 )
2017
22
Protein-losing enteropathy in a patient on peritoneal dialysis. ( 28434705 )
2017
23
Towards a proposal for a universal diagnostic definition of protein-losing enteropathy in Fontan patients: a systematic review. ( 27033590 )
2016
24
Successful therapy for protein-losing enteropathy caused by chronic neuronopathic Gaucher disease. ( 27014572 )
2016
25
Protein Losing Enteropathy After Cardiac Transplantation Successfully Treated by Stent Implantation. ( 27549730 )
2016
26
Thoracic Duct Decompression for Protein-Losing Enteropathy in Failing Fontan Circulation. ( 27211948 )
2016
27
Hypoadrenocorticism mimicking protein-losing enteropathy in 4 dogs. ( 27429465 )
2016
28
Protein-losing enteropathy with entestinal lymphangiectasia in skeletal dysplasia with Lys650Met mutation. ( 27214123 )
2016
29
Neonatal diabetes and protein losing enteropathy: a case report. ( 27098067 )
2016
30
Hypothyroidism and protein-losing enteropathy: A case report. ( 26705734 )
2016
31
Protein-losing enteropathy in camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome. ( 27224999 )
2016
32
Thromboembolism in Dogs with Protein-Losing Enteropathy with Non-Neoplastic Chronic Small Intestinal Disease. ( 27841681 )
2016
33
Protein-losing enteropathy in a patient with familial adenomatous polyposis and advanced colon cancer. ( 27170298 )
2016
34
Marginal Zone Lymphoma Complicated by Protein Losing Enteropathy. ( 27891267 )
2016
35
Protein-losing enteropathy and erythema caused by egg allergy in a breast-fed infant. ( 26818703 )
2016
36
Retrospective evaluation of the administration of 25% human albumin to dogs with protein-losing enteropathy: 21 cases (2003-2013). ( 27159733 )
2016
37
Effectiveness of High-dose Spironolactone Therapy in a Patient with Recurrent Protein-losing Enteropathy after the Fontan Procedure. ( 27301514 )
2016
38
Original Surgical Procedure for the Treatment of Protein-Losing Enteropathy in Fontan Patients: Report of Two Midterm Successes. ( 27550969 )
2016
39
Everolimus for Primary Intestinal Lymphangiectasia With Protein-Losing Enteropathy. ( 26908672 )
2016
40
Constrictive Pericarditis and Protein-Losing Enteropathy: Is Extremely Severe Hypoalbuminemia Reversible by Pericardiectomy? ( 27864304 )
2016
41
Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations. ( 26883093 )
2016
42
Factors related to outcomes in lupus-related protein-losing enteropathy. ( 26552467 )
2015
43
Photo quiz. Diarrhea, anasarca, and severe hypoalbuminemia in an AIDS patient. Diagnosis: AIDS-related visceral Kaposi sarcoma (KS) with protein-losing enteropathy (PLE). ( 25801550 )
2015
44
Gastrointestinal: Endoscopic findings of collagenous gastroenterocolitis with protein-losing enteropathy. ( 25916480 )
2015
45
Protein-losing enteropathy in a patient on ketogenic diet for limbic encephalitis--treatment effect or underlying pathology? ( 25979660 )
2015
46
Immune Abnormalities in Fontan Protein-Losing Enteropathy: A Case-Control Study. ( 26009017 )
2015
47
Transnodal lymphangiography and post-CT for protein-losing enteropathy in Noonan syndrome. ( 25636017 )
2015
48
BehAset disease and protein-losing enteropathy due to intestinal lymphangiectasia. ( 25661471 )
2015
49
Protein-losing enteropathy in inflammatory bowel diseases. ( 26446687 )
2015
50
Protein-losing enteropathy associated with refractory systemic lupus erythematosus with a good response to rituximab. ( 25818375 )
2015

Variations for Protein-Losing Enteropathy

ClinVar genetic disease variations for Protein-Losing Enteropathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CD55 NM_001114752.1(CD55): c.43delC (p.Leu15Serfs) deletion Pathogenic rs1114167430 GRCh37 Chromosome 1, 207495153: 207495153
2 CD55 NM_000574.4(CD55): c.110delG (p.Gly37Alafs) deletion Pathogenic rs1135402915 GRCh37 Chromosome 1, 207495736: 207495736
3 CD55 NM_000574.4(CD55): c.149_150delAAinsCCTT (p.Glu50Alafs) indel Pathogenic rs1135402916 GRCh37 Chromosome 1, 207495775: 207495776
4 CD55 NM_000574.4(CD55): c.800G> C (p.Cys267Ser) single nucleotide variant Pathogenic rs1135402917 GRCh38 Chromosome 1, 207331243: 207331243
5 CD55 NM_000574.4(CD55): c.287-1G> A single nucleotide variant Pathogenic rs1135402918 GRCh37 Chromosome 1, 207497903: 207497903

Expression for Protein-Losing Enteropathy

Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for Protein-Losing Enteropathy

GO Terms for Protein-Losing Enteropathy

Cellular components related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 9.16 CD55 SERPINA1
2 endoplasmic reticulum GO:0005783 9.02 ALB ALG6 ANTXR2 DGAT1 SERPINA1
3 platelet alpha granule lumen GO:0031093 8.96 ALB SERPINA1

Sources for Protein-Losing Enteropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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