MCID: PRT019
MIFTS: 47

Protein-Losing Enteropathy malady

Gastrointestinal diseases category

Aliases & Classifications for Protein-Losing Enteropathy

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Protein-Losing Enteropathy, Aliases & Descriptions:

Name: Protein-Losing Enteropathy 9 11
Protein-Losing Enteropathies 43 60
 
Enteropathy, Exudative 9
Exudative Enteropathy 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:10611
SNOMED-CT55 66972006, 22542007
MeSH33 D011504

Summaries for Protein-Losing Enteropathy

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Wikipedia:63 Protein losing enteropathy refers to any condition of the gastrointestinal tract that results in a net... more...

MalaCards based summary: Protein-Losing Enteropathy, also known as protein-losing enteropathies, is related to gastroenteritis and connective tissue disease, and has symptoms including autosomal recessive inheritance, edema and clubbing. An important gene associated with Protein-Losing Enteropathy is MPI (mannose phosphate isomerase), and among its related pathways are Selected targets of HNF1 and Selected targets of C EBPalpha. The compounds tolmetin glucuronide and pirprofen have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and liver.

Related Diseases for Protein-Losing Enteropathy

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Diseases related to Protein-Losing Enteropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1gastroenteritis31.6CD79A
2connective tissue disease31.1CD79A, ALB
3congenital heart disease31.0ALB, CD79A, NPPB
4amyloidosis31.0CD79A, ALB, NPPB
5diarrhea30.9CD79A, ALB
6protein-energy malnutrition30.9TF, ALB
7hepatitis30.8ALB, SERPINA1, TF
8bronchitis30.6SERPINA1, CD79A
9pulmonary embolism30.6ALB, NPPB
10lupus nephritis30.6CD79A, ALB
11deficiency anemia30.6CD79A, ALB, TF
12nephritis30.4CD79A, ALB
13liver cirrhosis30.4TF, SERPINA1, ALB
14pneumonia30.4SERPINA1, OXA1L, CD79A
15cholestasis30.3ALB, SERPINA1
16vasculitis30.2SERPINA1, ALB, CD79A
17burkitt lymphoma29.9ALB, OXA1L, CD79A, SERPINA1
18lupus erythematosus11.0
19systemic lupus erythematosus11.0
20eosinophilic gastroenteritis10.7
21constrictive pericarditis10.7
22colitis10.7
23pericarditis10.7
24crohn's disease10.6
25purpura10.6
26rheumatoid arthritis10.5
27arthritis10.5
28ulcerative colitis10.5
29collagenous colitis10.5
30cronkhite-canada syndrome10.5
31dermatitis10.5
32lymphangiomatosis10.5
33cap polyposis10.5
34congenital disorder of glycosylation, type ib10.5
35neuroblastoma10.5
36lymphedema10.5
37langerhans-cell histiocytosis10.5
38portal hypertension10.5
39measles10.5
40mixed connective tissue disease10.5
41food allergy10.5
42histiocytosis10.5
43sarcoma10.5
44congenital hepatic fibrosis10.5
45lymphangiectasis10.5
46congenital chronic diarrhea with protein-losing enteropathy10.5
47dysentery10.4CD79A
48pyelonephritis10.4CD79A
49acute poststreptococcal glomerulonephritis10.4CD79A
50siderosis10.4TF

Graphical network of the top 20 diseases related to Protein-Losing Enteropathy:



Diseases related to protein-losing enteropathy

Symptoms for Protein-Losing Enteropathy

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HPO human phenotypes related to Protein-Losing Enteropathy:

(show all 11)
id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 edema HP:0000969
3 clubbing HP:0001217
4 growth delay HP:0001510
5 ascites HP:0001541
6 iron deficiency anemia HP:0001891
7 diarrhea HP:0002014
8 abdominal pain HP:0002027
9 abnormality of the intestine HP:0002242
10 budd-chiari syndrome HP:0002639
11 hypoproteinemia HP:0003075

Drugs & Therapeutics for Protein-Losing Enteropathy

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Drug clinical trials:

Search ClinicalTrials for Protein-Losing Enteropathy

Search NIH Clinical Center for Protein-Losing Enteropathy

Genetic Tests for Protein-Losing Enteropathy

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Anatomical Context for Protein-Losing Enteropathy

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MalaCards organs/tissues related to Protein-Losing Enteropathy:

31
Heart, Small intestine, Liver, Colon, Bone, Testes, Bone marrow, Lymph node, Lung, Thyroid, Breast, Skin, T cells, B cells, Endothelial, Neutrophil

Animal Models for Protein-Losing Enteropathy or affiliated genes

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Publications for Protein-Losing Enteropathy

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Articles related to Protein-Losing Enteropathy:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Oral budesonide as a therapy for protein-losing enteropathy in children after the Fontan operation. (24889258)
2014
2
Comparison of a chlorambucil-prednisolone combination with an azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007-2010). (23725434)
2013
3
Use of oral budesonide in the management of protein-losing enteropathy due to restrictive cardiomyopathy. (24029379)
2013
4
Progressive mesenteric lymphadenopathy with protein-losing enteropathy; a devastating complication in Gaucher disease. (22227073)
2012
5
Chronic diarrhea, ascites, and protein-losing enteropathy in an infant with hepatic venous outflow obstruction after liver transplantation. (22489846)
2012
6
Recurrent protein-losing enteropathy and tricuspid valve insufficiency in a transplanted heart: a causal relationship? (21801319)
2012
7
Protein-Losing Enteropathy in a Post-partum Female Secondary to Metastatic Melanoma of the Gut: Report of a Case. (22006436)
2011
8
Protein-losing enteropathy caused by spontaneous superior mesenteric artery dissection with thrombosis. (21086951)
2010
9
Protein-losing enteropathy associated with Henoch-SchAPnlein purpura. (21589833)
2010
10
Protein-losing enteropathy with mesenteric venous thrombosis: a forme fruste of systemic lupus erythematosus. (19812125)
2009
11
Protein-losing enteropathy post-valvular surgery with severe tricuspid regurgitation in Subutex-related endocarditis. (19421664)
2009
12
Protein-losing enteropathy after the Fontan operation: associations and predictors of clinical outcome. (18715460)
2008
13
Protein-losing enteropathy detected by Tc-99m-MDP abdominal scintigraphy. (18604530)
2008
14
Protein-losing enteropathy in systemic lupus erythematosus: analysis of the clinical features of fifteen patients. (18176138)
2007
15
Resolution of protein-losing enteropathy after radiofrequency perforation and subsequent stent implantation for relief of complete occlusion of a redirected left superior vena cava. (16764003)
2006
16
Scintigraphic diagnosis of protein-losing enteropathy secondary to amyloidosis. (16252188)
2005
17
Protein-losing enteropathy. (15557963)
2004
18
A case of severe protein-losing enteropathy as a late complication of pelvic irradiation. (15683118)
2004
19
Reversal of protein-losing enteropathy with calcium replacement in a patient after Fontan operation. (15063295)
2004
20
Protein-losing enteropathy caused by Lawsonia intracellularis in a weanling foal. (12619560)
2003
21
Protein-losing enteropathy detected on Tc-99m HSA and Tc-99m MDP scintigraphy. (12045436)
2002
22
Protein-losing enteropathy complicated with recurrent convulsions and developmental delay in a 4-month-old boy. (12421272)
2002
23
Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology. (11958575)
2002
24
Right ventricular cardiomyopathy accompanied by protein-losing enteropathy and chylous effusion. (11665798)
2001
25
Treatment of iron deficiency anemia and associated protein-losing enteropathy in children. (10695822)
2000
26
Heparin therapy and reversal of protein-losing enteropathy in a case with congenital heart disease. (10818189)
2000
27
Protein-losing enteropathy with an endoscopic feature of 'the watermelon colon'. (10755263)
1999
28
Transjugular intrahepatic portosystemic shunt as a treatment for protein-losing enteropathy caused by portal hypertension. (8942750)
1996
29
Protein losing enteropathy as the initial manifestation of childhood systemic lupus erythematosus. (8823704)
1996
30
Protein-losing enteropathy after the modified fontan operation: oral prednisone treatment with biopsy and laboratory proved improvement. (8833498)
1996
31
Generalized giant inflammatory polyposis in a patient with ulcerative colitis presenting with protein-losing enteropathy. (7733100)
1995
32
Protein-losing enteropathy from cap polyposis. (7491082)
1995
33
A case of protein-losing enteropathy in idiopathic thrombocytopenic purpura with decreased IgA. (8061805)
1994
34
Oral administration of cromolyn in a patient with protein-losing enteropathy, food allergy, and eosinophilic gastroenteritis. (8170195)
1994
35
Protein-losing enteropathy with collagenous colitis. (1590320)
1992
36
Tc-99m human serum albumin abdominal scanning in protein-losing enteropathy. (2258219)
1990
37
Protein-losing enteropathy detected by 99mTc-labeled human serum albumin abdominal scintigraphy. (3264334)
1988
38
Pure red cell aplasia and protein-losing enteropathy in a patient with systemic lupus erythematosus. (3929798)
1985
39
Administration of intravenous immunoglobulin in two children with hypogammaglobulinaemia due to protein losing enteropathy. (4006307)
1985
40
Protein-losing enteropathy caused by systemic lupus erythematosus. (18668866)
1985
41
Protein-losing enteropathy with small intestinal stenoses and a stagnant loop in a nine-year-old boy. (7136667)
1982
42
Congenital Letterer-Siwe disease associated with protein losing enteropathy. (7449792)
1980
43
Congenital hepatic fibrosis combined with protein-losing enteropathy and recurrent thrombosis. (7446108)
1980
44
Protein-losing enteropathy in a boy with systemic lupus erythematosus. (7431171)
1980
45
Protein-losing enteropathy due to gastro-intestinal amyloidosis. (523374)
1979
46
Budd-Chiari syndrome associated with protein-losing enteropathy. (401086)
1978
47
Severe enamel hypoplasia in a case of intestinal lymphangiectasia: a rare protein-losing enteropathy. (266150)
1977
48
Protein-losing enteropathy and malabsorption in regional enteritis: cure by limited ileal resection. (4748296)
1973
49
Protein-losing enteropathy caused by a retained intestinal tube. (5413020)
1970
50
Gastrointestinal polyposis with protein-losing enteropathy, abnormal skin pigmentation and loss of hair and nails (Cronkhite-Canada syndrome). (5808657)
1969

Variations for Protein-Losing Enteropathy

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Expression for genes affiliated with Protein-Losing Enteropathy

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Search GEO for disease gene expression data for Protein-Losing Enteropathy.

Pathways for genes affiliated with Protein-Losing Enteropathy

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Pathways related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.6ALB, SERPINA1, TF
2
Show member pathways
8.6ALB, SERPINA1, TF

Compounds for genes affiliated with Protein-Losing Enteropathy

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Compounds related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1tolmetin glucuronide4310.0ALB, OXA1L
2pirprofen4310.0ALB, OXA1L
3kebuzone4310.0ALB, OXA1L
4rhsa439.9ALB, OXA1L
5sodium octanoate439.9OXA1L, ALB
6dansylsarcosine439.9OXA1L, ALB
7azapropazone43 1210.9ALB, OXA1L
8hhpa439.9ALB, OXA1L
9acetyldigitoxin43 1210.9ALB, OXA1L
10eprex439.9OXA1L, ALB
11dansylamide43 1210.9OXA1L, ALB
12cyclosarin439.8ALB, OXA1L
13fenoprofen28 43 1211.8OXA1L, ALB
14(s)-ketoprofen439.8OXA1L, ALB
15sulfisoxazole43 49 59 1212.8ALB, OXA1L
16polyvinylpyrrolidone439.8ALB, OXA1L
17oxyphenbutazone43 1210.7ALB, OXA1L
18n(epsilon)-(carboxymethyl)lysine439.7ALB, OXA1L
19cellulose acetate439.7CD79A, ALB, MPI
20indoxyl sulfate439.7ALB, OXA1L
21kp-1019439.6TF, ALB
22polyvinyl alcohol439.6ALB, OXA1L
23sinapic acid439.5TF, OXA1L
24ramipril43 1210.5NPPB, ALB, CD79A
25piroxicam43 1210.5CD79A, ALB, OXA1L
26captopril43 59 49 28 1213.5ALB, NPPB, CD79A
27phenytoin43 49 28 1212.5CD79A, ALB, OXA1L
28warfarin43 49 24 1212.4CD79A, OXA1L, ALB
29furosemide43 59 28 49 24 1214.4OXA1L, ALB, NPPB
30phenylbutazone43 1210.4OXA1L, ALB, SERPINA1
31nitrilotriacetic acid43 1210.3TF, OXA1L
32tolmetin43 1210.2ALB, OXA1L
33salicylic acid43 2810.2OXA1L, ALB, SERPINA1
34suprofen43 1210.2OXA1L, TF, ALB
35dtpa439.1ALB, OXA1L, TF
36vitamin b12439.1ALB, CD79A, TF
37sodium dodecylsulfate439.1CD79A, ALB, OXA1L
38bicarbonate439.0ALB, TF, NPPB
39glutaraldehyde438.7TF, OXA1L, ALB, CD79A
40polyethylene glycol438.7OXA1L, TF, ALB, CD79A
41prednisolone43 28 1210.7CD79A, NPPB, ALB, TF
42tacrolimus43 49 1210.7TF, ALB, NPPB, CD79A
43histamine43 28 2410.6NPPB, ALB, TF, CD79A
44ascorbic acid43 249.5SERPINA1, TF, ALB, CD79A
45cysteine438.2ALB, OXA1L, NPPB, CD79A, SERPINA1
46thyroxine43 249.2TF, OXA1L, ALB, NPPB, CD79A
47lactate438.2TF, ALB, CD79A, NPPB
48iron43 249.1ALB, NPPB, SERPINA1, TF
49fibrinogen438.1TF, SERPINA1, OXA1L, ALB, CD79A
50creatinine438.1CD79A, TF, SERPINA1, ALB, NPPB

GO Terms for genes affiliated with Protein-Losing Enteropathy

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Cellular components related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.1ALB, SERPINA1
2protein complexGO:00432349.0NPPB, ALB, OXA1L
3extracellular regionGO:00055768.1NPPB, ALB, SERPINA1, TF
4extracellular spaceGO:00056158.0TF, SERPINA1, ALB, NPPB

Biological processes related to Protein-Losing Enteropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dolichol-linked oligosaccharide biosynthetic processGO:00064889.7MPI, ALG6
2retina homeostasisGO:00018958.9TF, ALB
3platelet degranulationGO:00025768.7ALB, SERPINA1, TF
4platelet activationGO:00301688.6TF, SERPINA1, ALB
5blood coagulationGO:00075968.6ALB, SERPINA1, TF

Products for genes affiliated with Protein-Losing Enteropathy

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Sources for Protein-Losing Enteropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet