MCID: PRT039
MIFTS: 58

Proteinuria malady

Nephrological diseases category
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Summaries for Proteinuria

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Wikipedia:65 Proteinuria (/pro?ti??n??ri?/ or /pro?ti??nj??ri?/; from protein and urine) means the presence of an... more...

MalaCards based summary: Proteinuria, also known as proteinuria nos, is related to focal segmental glomerulosclerosis and nephrosis. An important gene associated with Proteinuria is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Nephrin/Neph1 signaling in the kidney podocyte and Diseases associated with visual transduction. The compounds puromycin aminonucleoside and 1,3-dichloropropene have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are vision/eye and liver/biliary system.

Aliases & Classifications for Proteinuria

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 57SNOMED-CT, 39NCIt, 62UMLS, 34MeSH
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Proteinuria, Aliases & Descriptions:

Name: Proteinuria 8 10 44
 
Proteinuria Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:576
ICD9CM27 791.0
NCIt39 C38012
MeSH34 D011507

Related Diseases for Proteinuria

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Diseases related to Proteinuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1focal segmental glomerulosclerosis31.6PLCE1
2nephrosis31.4NPHS1, NPHS2
3amyloidosis31.0ALB, RBP4, CD79A
4dent's disease31.0LRP2, CLCN5
5chronic pyelonephritis31.0NAGLU
6fanconi syndrome30.9LRP2, CLCN5
7hypertension30.9UTS2, ACE, ALB, CD79A
8lupus nephritis30.8CD79A, RBP4, ALB, NAGLU
9pyelonephritis30.7CD79A, NAGLU
10nephrocalcinosis30.7LRP2, CLCN5, NAGLU
11glomerulosclerosis30.6ACE, ALB, NPHS1, NPHS2, CD79A
12pre-eclampsia30.6NAGLU, UTS2, ANGPT2, NPHS1, NPHS2
13oculocerebrorenal syndrome30.5NAGLU, LRP2
14glomerulonephritis30.4CD79A, NPHS2, NPHS1, RBP4, ALB, NAGLU
15anuria30.4ACE
16membranous glomerulonephritis30.3LRP2, ALB, NPHS1, NPHS2, CD79A
17congenital nephrotic syndrome finnish type30.3NPHS1, NPHS2
18congestive heart failure30.3UTS2
19acute poststreptococcal glomerulonephritis30.2CD79A, CFP
20vascular disease30.2ANGPT2
21peripheral vascular disease30.1ALB, CD79A
22myeloma30.1NAGLU, ANGPT2, ALB, CD79A
23lipoid nephrosis30.1NAGLU, ALB, NPHS1, NPHS2, CD79A
24membranoproliferative glomerulonephritis30.1CD79A, NPHS1, CFP
25agammaglobulinemia30.0CD79A, CFP
26systemic lupus erythematosus30.0CD79A, RBP4, CFP, LRP2
27rheumatoid arthritis29.9LRP2, NAGLU, ANGPT2, CD79A, CTSL
28nephritis29.9CD79A, NPHS2, NPHS1, RBP4, ALB, ACE
29nephrotic syndrome29.9ALB, PLCE1, ACE, NAGLU, RBP4, NPHS1
30pneumonia29.9CD79A, RBP4, NAGLU
31diabetic retinopathy29.9ALB, ACE, ANGPT2, NAGLU
32liver cirrhosis29.9RBP4, ALB, UTS2
33diabetic nephropathy29.7NAGLU, UTS2, FABP1, ACE, ALB, RBP4
34glucose intolerance29.7CD79A, FABP1, APOA4
35essential hypertension29.7ALB, ACE, UTS2, NAGLU
36hyperglycemia29.5APOA4, NAGLU, ACE, ALB, NPHS1
37insulin resistance29.5NPHS1, RBP4, ALB, ACE, UTS2, APOA4
38type 1 diabetes mellitus29.4APOA4, NAGLU, ACE, ALB, RBP4, CD79A
39acute myocardial infarction29.3ACE, ANGPT2, UTS2, NAGLU
40myocardial infarction29.3ACE, UTS2, NAGLU, APOA4
41type 2 diabetes mellitus29.1APOA4, NAGLU, UTS2, ACE, ALB, RBP4
42diabetes mellitus29.0CFP, CD79A, NPHS1, RBP4, ALB, ACE
43atherosclerosis28.7LRP2, APOA4, UTS2, ANGPT2, ACE, ALB
44kidney disease10.7
45orthostatic proteinuria10.6
46hepatorenal syndrome10.5ALB
47intracranial hypertension10.5ALB
48protein-losing enteropathy10.5ALB
49hyperthyroxinemia10.5ALB
50endotheliitis10.4

Graphical network of the top 20 diseases related to Proteinuria:



Diseases related to proteinuria

Symptoms for Proteinuria

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Drugs & Therapeutics for Proteinuria

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Drug clinical trials:

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Search NIH Clinical Center for Proteinuria

Genetic Tests for Proteinuria

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Anatomical Context for Proteinuria

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MalaCards organs/tissues related to Proteinuria:

32
Kidney, Endothelial, Testes, Heart, Pancreas, Bone, Liver, T cells, Spinal cord, Thyroid, Monocytes, B cells, Bone marrow, Eye, Brain, Lung, Ovary, Prostate

Animal Models for Proteinuria or affiliated genes

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MGI Mouse Phenotypes related to Proteinuria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3CTSL, RBP4, ANGPT2, NAGLU, LRP2
2MP:00053708.0CLCN5, NAGLU, FABP1, ACE, ALB, CTSL
3MP:00053817.8LRP2, APOA4, ANGPT2, ALB, CTSL
4MP:00053677.6LRP2, CLCN5, NAGLU, ACE, ALB, NPHS1
5MP:00053847.3LRP2, APOA4, CLCN5, NAGLU, ACE, ALB
6MP:00053857.2CFP, APOA4, NAGLU, ANGPT2, ACE, PLCE1
7MP:00053877.0CFP, APOA4, NAGLU, ANGPT2, ACE, CD79A
8MP:00107686.4LRP2, CFP, APOA4, NAGLU, ANGPT2, ACE
9MP:00053765.2CTSL, LRP2, CFP, APOA4, CLCN5, FABP1

Publications for Proteinuria

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Articles related to Proteinuria:

(show top 50)    (show all 1163)
idTitleAuthorsYear
1
Prevalence of hypertension in healthy school children in Pakistan and its relationship with body mass index, proteinuria and hematuria. (24434408)
2014
2
Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1I^ monoclonal antibody canakinumab. (24510061)
2014
3
Close association between proteinuria and regulatory T cells in patients with idiopathic nephrotic syndrome. (23263711)
2013
4
Factors related to nephrotic-range proteinuria in late-stage chronic kidney disease patients with diabetes mellitus. (23355027)
2013
5
Hypertension and kidney function in an adult population of West Bengal, India: Role of body weight, waist circumference, proteinuria and rural area living. (23889782)
2013
6
Proteinuria as a risk factor for mortality in patients with colorectal cancer. (23918569)
2013
7
The phosphorus-proteinuria interaction in chronic kidney disease. (23229931)
2013
8
Dasatinib-induced nephrotic-range proteinuria. (23540262)
2013
9
Proteinuria as a risk marker for the progression of chronic kidney disease in patients on predialysis care and the role of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment. (23128440)
2012
10
Simultaneous measurement of urinary albumin and total protein may facilitate decision-making in HIV-infected patients with proteinuria. (22413854)
2012
11
The relation between urinary angiotensinogen and proteinuria in renal AA amyloidosis patients. (22320202)
2012
12
Causes and consequences of proteinuria following kidney transplantation. (21738244)
2011
13
Proteinuria among adult sickle cell anemia patients in Nigeria. (21311153)
2011
14
Urine dipstick to detect trace proteinuria: an underused tool for an underappreciated risk marker. (21684434)
2011
15
Proteinuria in an African HIV-infected patient: effects of telmisartan. (21753253)
2011
16
Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. (21844484)
2011
17
Association between serum soluble TNFI+ receptors and renal dysfunction in type 2 diabetic patients without proteinuria. (21288590)
2011
18
Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study. (20309434)
2010
19
Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients. (18261172)
2008
20
Molecular mechanisms of proteinuria in diabetes. (18793166)
2008
21
Proteinuria: is it all in the foot? (17671644)
2007
22
Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly patients. (17722705)
2007
23
Effect of renin-angiotensin system in Fabry disease associated proteinuria]. (17397632)
2007
24
Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis. (17239933)
2007
25
ACE inhibition can improve orthostatic proteinuria associated with nutcracker syndrome. (16902785)
2006
26
Insulin resistance contributes to obesity-related proteinuria. (16020878)
2005
27
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients. (14747236)
2004
28
A 3-year-old child with proteinuria and nephrocalcinosis. Suspicion of Dent disease. (15365802)
2004
29
Association between polymorphisms of the atrial natriuretic peptide gene and proteinuria: a population-based study. (12687344)
2003
30
Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomerulonephritis. (11981066)
2002
31
High proteinuria selectivity index based upon IgM is a strong predictor of poor renal survival in glomerular diseases. (11427625)
2001
32
Genetic kidney diseases disclose the pathogenesis of proteinuria. (11730159)
2001
33
Effect of fluvastatin on proteinuria in patients with immunoglobulin A nephropathy. (10801253)
2000
34
Induction of microalbuminuria by l-arginine infusion in healthy individuals: an insight into the mechanisms of proteinuria. (10352188)
1999
35
Monitoring of proteinuria in phase I studies in healthy male subjects. (9696951)
1998
36
Mesangial hyperplasia in a patient with renovascular hypertension and proteinuria. (9794597)
1998
37
Proteinuria and tubulointerstitial injury. (9328968)
1997
38
Characterization of proteinuria in primary glomerulonephritides: urinary polymers of albumin. (9292570)
1997
39
Prednisone improves renal function and proteinuria in human immunodeficiency virus-associated nephropathy. (8686713)
1996
40
An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis. (8872972)
1996
41
Hyponatremic hypertensive syndrome and massive proteinuria in a patient with renin-producing leiomyosarcoma. (8023829)
1994
42
Value of fructosamine test in monitoring of diabetes complicated by proteinuria]. (8284241)
1993
43
The effect of enalapril on proteinuria in patients with chronic glomerulonephritis and renal insufficiency. (8139137)
1993
44
High-sensitivity electrophoretic method for the detection of Bence Jones protein and for the study of proteinuria in unconcentrated urines. (7685986)
1993
45
Changes of negative charge on RBC and glomeruli and its relation to the proteinuria of adriamycin nephrosis in rats. (1879220)
1991
46
Clinicopathological study of patients presenting hematuria and proteinuria by renal biopsy]. (2046202)
1991
47
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. (4038407)
1985
48
Effect of praziquantel on hematuria and proteinuria in urinary schistosomiasis. (3938926)
1985
49
Acquired antithrombin III deficiency in patients with glomerular proteinuria. (689489)
1978
50
D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. (1203037)
1975

Variations for Proteinuria

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Expression for genes affiliated with Proteinuria

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Expression patterns in normal tissues for genes affiliated with Proteinuria

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Pathways for genes affiliated with Proteinuria

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Compounds for genes affiliated with Proteinuria

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Compounds related to Proteinuria according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1puromycin aminonucleoside4410.3NPHS1, NPHS2
21,3-dichloropropene4410.3NAGLU, RBP4
3iopentol4410.2NAGLU, ALB
4p-aminohippuric acid4410.2NAGLU, ALB
5tobramycin4410.2NAGLU, RBP4
6perchloroethylene4410.1RBP4, NAGLU
7fructosamine44 2411.0RBP4, ALB, NAGLU
8aminoglycosides449.9LRP2, NAGLU
9cellulose acetate449.9ALB, RBP4, CD79A
10inulin449.9ALB, NAGLU
11vitamin b12449.9CD79A, ALB, LRP2
12indapamide44 1110.8ALB, ACE
13uric acid44 2410.7RBP4, NAGLU, ALB
14perindopril44 50 1111.7NAGLU, ACE, ALB
15enalapril44 50 1111.7ACE, NAGLU, ALB
16thyroxine44 2410.7CD79A, LRP2, ALB, RBP4
17folate449.6ALB, RBP4, CD79A, LRP2
18phosphorus449.6ALB, RBP4, CFP, NAGLU
19furosemide44 61 28 50 24 1114.6ACE, NAGLU, ALB
20dextran sulfate449.6CTSL, CFP, ALB
21ramipril44 1110.6CD79A, ALB, ACE
22aprotinin44 1110.6CTSL, LRP2, NAGLU
23captopril44 61 50 28 1113.6ACE, ALB, CD79A
24warfarin44 50 24 1112.5ACE, ALB, CD79A
25vitamin d449.5CD79A, ALB, NAGLU, LRP2
26gamma globulin449.5CD79A, ALB
27indomethacin44 28 61 1112.5ALB, UTS2, NPHS1, CD79A
28losartan44 50 28 1112.5ACE, ALB, NAGLU
29ascorbic acid44 2410.4CD79A, ALB, RBP4, CFP
30kininogen449.3ACE, CTSL, ALB
31vitamin a44 24 1111.3LRP2, APOA4, NAGLU, RBP4, ALB
32magnesium44 24 1111.3LRP2, NAGLU, RBP4, ALB, CFP
33oleic acid44 28 24 1112.2ALB, FABP1, APOA4
34phospholipid449.1LRP2, APOA4, FABP1, RBP4
35sodium44 2410.0LRP2, NAGLU, UTS2, ACE, ALB
36fibrinogen448.8ANGPT2, APOA4, CD79A, ALB
37cyclosporin a44 28 6110.6CTSL, CD79A, NPHS2, NAGLU, ANGPT2
38heparin44 28 24 1111.4CD79A, ALB, LRP2, CTSL, NAGLU, APOA4
39h2o2448.3CLCN5, NAGLU, UTS2, FABP1, CD79A, ANGPT2
40dexamethasone44 50 28 1111.2CTSL, RBP4, FABP1, ANGPT2, NPHS1, CD79A
41vegf448.0CTSL, NPHS1, CD79A, FABP1, UTS2, ANGPT2
42nitric oxide44 24 1110.0LRP2, NAGLU, ACE, ANGPT2, UTS2
43retinoic acid44 248.9CTSL, NPHS1, RBP4, ANGPT2, FABP1, LRP2
44steroid447.9NPHS2, CTSL, ANGPT2, NAGLU, CD79A, LRP2
45cholesterol44 28 24 1110.7UTS2, ACE, NAGLU, APOA4, LRP2, FABP1
46cysteine447.5RBP4, UTS2, ANGPT2, CFP, ALB, NAGLU
47lipid447.3NPHS1, RBP4, ALB, ACE, FABP1, UTS2
48glucose446.4CTSL, NAGLU, ANGPT2, APOA4, UTS2, FABP1
49calcium44 50 24 119.4ALB, LRP2, CLCN5, ACE, ANGPT2, CTSL
50creatinine445.6NAGLU, CLCN5, NPHS2, NPHS1, RBP4, ALB

GO Terms for genes affiliated with Proteinuria

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Cellular components related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:0360579.9NPHS1, NPHS2
2lysosomeGO:0057649.4CTSL, NAGLU, LRP2
3protein complexGO:0432349.4NPHS2, NPHS1, RBP4, ALB
4membrane raftGO:0451219.3CD79A, NPHS2, NPHS1
5extracellular vesicular exosomeGO:0700627.8LRP2, NAGLU, FABP1, ACE, ALB, RBP4
6extracellular spaceGO:0056156.8CTSL, CFP, APOA4, UTS2, ANGPT2, ACE
7extracellular regionGO:0055766.8CFP, APOA4, UTS2, ANGPT2, ACE, ALB

Biological processes related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excretionGO:0075889.8NPHS2, NPHS1, CLCN5
2lipoprotein metabolic processGO:0421579.7ALB, APOA4
3retinoid metabolic processGO:0015239.5RBP4, APOA4, LRP2
4phototransduction, visible lightGO:0076039.4LRP2, APOA4, RBP4
5small molecule metabolic processGO:0442818.1ALB, PLCE1, FABP1, NAGLU, APOA4, LRP2

Molecular functions related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fatty acid bindingGO:0055049.3FABP1, ALB
2antioxidant activityGO:0162099.2ALB, FABP1, APOA4
3drug bindingGO:0081448.9ALB, ACE, FABP1
4protein bindingGO:0055156.9ANGPT2, ACE, PLCE1, ALB, RBP4, NPHS1

Products for genes affiliated with Proteinuria

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Sources for Proteinuria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet