Summaries for Proteinuria

About this section


Wikipedia:63 Proteinuria (/pro?ti??n??ri?/ or /pro?ti??nj??ri?/; from protein and urine) means the presence of an... more...

MalaCards based summary: Proteinuria is related to focal segmental glomerulosclerosis and nephrosis. An important gene associated with Proteinuria is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Nephrin/Neph1 signaling in the kidney podocyte and Diseases associated with visual transduction. The compounds puromycin aminonucleoside and 1,3-dichloropropene have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are vision/eye and liver/biliary system.

Aliases & Classifications for Proteinuria

About this section
Sources:
11DISEASES, 43Novoseek
See all sources

Proteinuria, Aliases & Descriptions:

Name: Proteinuria 11 43


Related Diseases for Proteinuria

About this section

Diseases related to Proteinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 366)
idRelated DiseaseScoreTop Affiliating Genes
1focal segmental glomerulosclerosis31.5PLCE1
2nephrosis31.4NPHS1, NPHS2
3amyloidosis31.0ALB, RBP4, CD79A
4chronic pyelonephritis31.0NAGLU
5dent disease30.9LRP2, CLCN5
6fanconi syndrome30.9LRP2, CLCN5
7lupus nephritis30.7CD79A, RBP4, ALB, NAGLU
8nephrocalcinosis30.7LRP2, CLCN5, NAGLU
9pyelonephritis30.7CD79A, NAGLU
10congenital nephrotic syndrome finnish type30.6NPHS1, NPHS2
11glomerulosclerosis30.6ACE, ALB, NPHS1, NPHS2, CD79A
12preeclampsia/eclampsia 130.4NAGLU, UTS2, ANGPT2, NPHS1, NPHS2
13glomerulonephritis30.4CD79A, NPHS2, NPHS1, RBP4, ALB, NAGLU
14anuria30.3ACE
15lowe syndrome30.3NAGLU, LRP2
16congestive heart failure30.2UTS2
17agammaglobulinemia30.2CD79A, CFP
18acute poststreptococcal glomerulonephritis30.2CD79A, CFP
19vascular disease30.1ANGPT2
20peripheral vascular disease30.1ALB, CD79A
21myeloma30.1NAGLU, ANGPT2, ALB, CD79A
22lipoid nephrosis30.1NAGLU, ALB, NPHS1, NPHS2, CD79A
23membranoproliferative glomerulonephritis30.0CD79A, NPHS1, CFP
24systemic lupus erythematosus30.0CD79A, RBP4, CFP, LRP2
25rheumatoid arthritis29.9LRP2, NAGLU, ANGPT2, CD79A, CTSL
26nephritis29.9CD79A, NPHS2, NPHS1, RBP4, ALB, ACE
27nephrotic syndrome29.9ALB, PLCE1, ACE, NAGLU, RBP4, NPHS1
28pneumonia29.9CD79A, RBP4, NAGLU
29liver cirrhosis29.8RBP4, ALB, UTS2
30glucose intolerance29.7CD79A, FABP1, APOA4
31hyperglycemia29.5APOA4, NAGLU, ACE, ALB, NPHS1
32acute myocardial infarction29.3ACE, ANGPT2, UTS2, NAGLU
33myocardial infarction29.3ACE, UTS2, NAGLU, APOA4
34coronary artery disease29.2ACE, UTS2, APOA4
35iga glomerulonephritis29.1CFP, NAGLU, ACE, ALB, NPHS1, NPHS2
36atherosclerosis28.7LRP2, APOA4, UTS2, ANGPT2, ACE, ALB
37kidney disease10.7
38orthostatic proteinuria10.6
39hepatorenal syndrome10.5ALB
40intracranial hypertension10.5ALB
41protein-losing enteropathy10.5ALB
42hyperthyroxinemia10.5ALB
43endotheliitis10.4
44diffuse mesangial sclerosis10.4NPHS2, NPHS1
45obesity10.4
46gastroenteritis10.3CD79A
47nephrolithiasis10.3CLCN5, NAGLU
48protein-energy malnutrition10.3ALB, RBP4
49liver disease10.3CD79A, ALB
50megaloblastic anemia10.3

Graphical network of the top 20 diseases related to Proteinuria:



Diseases related to proteinuria

Symptoms for Proteinuria

About this section

Drugs & Therapeutics for Proteinuria

About this section

Drug clinical trials:

Search ClinicalTrials for Proteinuria

Search NIH Clinical Center for Proteinuria

Genetic Tests for Proteinuria

About this section

Anatomical Context for Proteinuria

About this section

MalaCards organs/tissues related to Proteinuria:

31
Kidney, Endothelial, Testes, Pancreas, Heart, Bone, Liver, T cells, Spinal cord, Thyroid, Monocytes, B cells, Bone marrow, Eye, Brain, Lung, Ovary, Prostate, Myeloid

Animal Models for Proteinuria or affiliated genes

About this section

MGI Mouse Phenotypes related to Proteinuria:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3CTSL, RBP4, ANGPT2, NAGLU, LRP2
2MP:00053708.0CLCN5, NAGLU, FABP1, ACE, ALB, CTSL
3MP:00053817.8LRP2, APOA4, ANGPT2, ALB, CTSL
4MP:00053677.6LRP2, CLCN5, NAGLU, ACE, ALB, NPHS1
5MP:00053847.3LRP2, APOA4, CLCN5, NAGLU, ACE, ALB
6MP:00053857.2CFP, APOA4, NAGLU, ANGPT2, ACE, PLCE1
7MP:00053877.0CFP, APOA4, NAGLU, ANGPT2, ACE, CD79A
8MP:00107686.4LRP2, CFP, APOA4, NAGLU, ANGPT2, ACE
9MP:00053765.2CTSL, LRP2, CFP, APOA4, CLCN5, FABP1

Publications for Proteinuria

About this section

Articles related to Proteinuria:

(show top 50)    (show all 1185)
idTitleAuthorsYear
1
Pentoxifylline attenuates proteinuria in anti-Thy1 glomerulonephritis via downregulation of NF-I_B and Smad2/3signaling. (25879629)
2015
2
Prevalence of hypertension in healthy school children in Pakistan and its relationship with body mass index, proteinuria and hematuria. (24434408)
2014
3
Close association between proteinuria and regulatory T cells in patients with idiopathic nephrotic syndrome. (23263711)
2013
4
Factors related to nephrotic-range proteinuria in late-stage chronic kidney disease patients with diabetes mellitus. (23355027)
2013
5
Hypertension and kidney function in an adult population of West Bengal, India: Role of body weight, waist circumference, proteinuria and rural area living. (23889782)
2013
6
Proteinuria as a risk factor for mortality in patients with colorectal cancer. (23918569)
2013
7
The phosphorus-proteinuria interaction in chronic kidney disease. (23229931)
2013
8
Dasatinib-induced nephrotic-range proteinuria. (23540262)
2013
9
Proteinuria as a risk marker for the progression of chronic kidney disease in patients on predialysis care and the role of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment. (23128440)
2012
10
Simultaneous measurement of urinary albumin and total protein may facilitate decision-making in HIV-infected patients with proteinuria. (22413854)
2012
11
The relation between urinary angiotensinogen and proteinuria in renal AA amyloidosis patients. (22320202)
2012
12
Causes and consequences of proteinuria following kidney transplantation. (21738244)
2011
13
Proteinuria among adult sickle cell anemia patients in Nigeria. (21311153)
2011
14
Urine dipstick to detect trace proteinuria: an underused tool for an underappreciated risk marker. (21684434)
2011
15
Proteinuria in an African HIV-infected patient: effects of telmisartan. (21753253)
2011
16
Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. (21844484)
2011
17
Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study. (20309434)
2010
18
The relationship between adiponectin levels and degree of proteinuria in patients with nephrotic and non-nephrotic proteinuria. (19142807)
2009
19
Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients. (18261172)
2008
20
Molecular mechanisms of proteinuria in diabetes. (18793166)
2008
21
Proteinuria: is it all in the foot? (17671644)
2007
22
Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly patients. (17722705)
2007
23
Effect of renin-angiotensin system in Fabry disease associated proteinuria]. (17397632)
2007
24
Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis. (17239933)
2007
25
ACE inhibition can improve orthostatic proteinuria associated with nutcracker syndrome. (16902785)
2006
26
Insulin resistance contributes to obesity-related proteinuria. (16020878)
2005
27
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients. (14747236)
2004
28
A 3-year-old child with proteinuria and nephrocalcinosis. Suspicion of Dent disease. (15365802)
2004
29
Association between polymorphisms of the atrial natriuretic peptide gene and proteinuria: a population-based study. (12687344)
2003
30
Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomerulonephritis. (11981066)
2002
31
High proteinuria selectivity index based upon IgM is a strong predictor of poor renal survival in glomerular diseases. (11427625)
2001
32
Genetic kidney diseases disclose the pathogenesis of proteinuria. (11730159)
2001
33
Effect of fluvastatin on proteinuria in patients with immunoglobulin A nephropathy. (10801253)
2000
34
Induction of microalbuminuria by l-arginine infusion in healthy individuals: an insight into the mechanisms of proteinuria. (10352188)
1999
35
Monitoring of proteinuria in phase I studies in healthy male subjects. (9696951)
1998
36
Mesangial hyperplasia in a patient with renovascular hypertension and proteinuria. (9794597)
1998
37
Proteinuria and tubulointerstitial injury. (9328968)
1997
38
Characterization of proteinuria in primary glomerulonephritides: urinary polymers of albumin. (9292570)
1997
39
Prednisone improves renal function and proteinuria in human immunodeficiency virus-associated nephropathy. (8686713)
1996
40
An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis. (8872972)
1996
41
Hyponatremic hypertensive syndrome and massive proteinuria in a patient with renin-producing leiomyosarcoma. (8023829)
1994
42
Value of fructosamine test in monitoring of diabetes complicated by proteinuria]. (8284241)
1993
43
The effect of enalapril on proteinuria in patients with chronic glomerulonephritis and renal insufficiency. (8139137)
1993
44
High-sensitivity electrophoretic method for the detection of Bence Jones protein and for the study of proteinuria in unconcentrated urines. (7685986)
1993
45
Changes of negative charge on RBC and glomeruli and its relation to the proteinuria of adriamycin nephrosis in rats. (1879220)
1991
46
Clinicopathological study of patients presenting hematuria and proteinuria by renal biopsy]. (2046202)
1991
47
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. (4038407)
1985
48
Effect of praziquantel on hematuria and proteinuria in urinary schistosomiasis. (3938926)
1985
49
Acquired antithrombin III deficiency in patients with glomerular proteinuria. (689489)
1978
50
D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. (1203037)
1975

Variations for Proteinuria

About this section

Expression for genes affiliated with Proteinuria

About this section
Search GEO for disease gene expression data for Proteinuria.

Pathways for genes affiliated with Proteinuria

About this section

Compounds for genes affiliated with Proteinuria

About this section

Compounds related to Proteinuria according to GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1puromycin aminonucleoside4310.3NPHS1, NPHS2
21,3-dichloropropene4310.3RBP4, NAGLU
3iopentol4310.2NAGLU, ALB
4p-aminohippuric acid4310.2NAGLU, ALB
5tobramycin4310.2NAGLU, RBP4
6perchloroethylene4310.1NAGLU, RBP4
7fructosamine43 2411.0RBP4, ALB, NAGLU
8aminoglycosides439.9NAGLU, LRP2
9cellulose acetate439.9CD79A, RBP4, ALB
10inulin439.9ALB, NAGLU
11vitamin b12439.9LRP2, ALB, CD79A
12indapamide43 1210.8ACE, ALB
13perindopril43 49 1211.7NAGLU, ACE, ALB
14enalapril43 49 1211.7NAGLU, ACE, ALB
15thyroxine43 2410.7LRP2, ALB, RBP4, CD79A
16folate439.6LRP2, ALB, RBP4, CD79A
17uric acid43 2410.6NAGLU, ALB, RBP4
18phosphorus439.6CFP, NAGLU, ALB, RBP4
19furosemide43 59 28 49 24 1214.6NAGLU, ACE, ALB
20dextran sulfate439.6CTSL, ALB, CFP
21ramipril43 1210.6CD79A, ALB, ACE
22iohexol439.6ALB, NAGLU
23aprotinin43 1210.6CTSL, NAGLU, LRP2
24captopril43 59 49 28 1213.6CD79A, ALB, ACE
25warfarin43 49 24 1212.5CD79A, ALB, ACE
26vitamin d439.5CD79A, ALB, NAGLU, LRP2
27indomethacin43 28 59 1212.5UTS2, ALB, NPHS1, CD79A
28losartan43 49 28 1212.5ALB, ACE, NAGLU
29ascorbic acid43 2410.4CD79A, RBP4, ALB, CFP
30kininogen439.3CTSL, ALB, ACE
31oleic acid43 28 24 1212.3APOA4, FABP1, ALB
32vitamin a43 24 1211.3LRP2, APOA4, NAGLU, ALB, RBP4
33magnesium43 24 1211.3LRP2, CFP, NAGLU, ALB, RBP4
34phospholipid439.1LRP2, APOA4, FABP1, RBP4
35sodium43 2410.0ALB, ACE, UTS2, NAGLU, LRP2
36fibrinogen438.8APOA4, ANGPT2, ALB, CD79A
37cyclosporin a43 28 5910.6NAGLU, ANGPT2, NPHS2, CD79A, CTSL
38heparin43 28 24 1211.4LRP2, CFP, APOA4, NAGLU, ALB, CD79A
39h2o2438.3CLCN5, NAGLU, UTS2, FABP1, ANGPT2, CD79A
40dexamethasone43 49 28 1211.2FABP1, ANGPT2, RBP4, NPHS1, CD79A, CTSL
41vegf438.0UTS2, FABP1, ANGPT2, NPHS1, CD79A, CTSL
42nitric oxide43 24 1210.0LRP2, NAGLU, UTS2, ANGPT2, ACE
43retinoic acid43 248.9LRP2, FABP1, ANGPT2, RBP4, NPHS1, CD79A
44steroid437.9LRP2, NAGLU, ANGPT2, RBP4, NPHS1, NPHS2
45cholesterol43 28 24 1210.7LRP2, APOA4, NAGLU, UTS2, FABP1, ACE
46cysteine437.5CFP, NAGLU, UTS2, ANGPT2, ALB, RBP4
47lipid437.3LRP2, APOA4, NAGLU, UTS2, FABP1, ACE
48glucose436.4APOA4, NAGLU, UTS2, FABP1, ANGPT2, ACE
49calcium43 49 24 129.4ANGPT2, UTS2, NAGLU, CLCN5, LRP2, ACE
50creatinine435.6CTSL, APOA4, CLCN5, NAGLU, UTS2, FABP1

GO Terms for genes affiliated with Proteinuria

About this section

Cellular components related to Proteinuria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:00360579.9NPHS1, NPHS2
2lysosomeGO:00057649.4CTSL, NAGLU, LRP2
3protein complexGO:00432349.4NPHS2, NPHS1, RBP4, ALB
4membrane raftGO:00451219.3CD79A, NPHS2, NPHS1
5extracellular vesicular exosomeGO:00700627.8LRP2, NAGLU, FABP1, ACE, ALB, RBP4
6extracellular spaceGO:00056156.8CTSL, CFP, APOA4, UTS2, ANGPT2, ACE
7extracellular regionGO:00055766.8CFP, APOA4, UTS2, ANGPT2, ACE, ALB

Biological processes related to Proteinuria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1excretionGO:00075889.8NPHS2, NPHS1, CLCN5
2lipoprotein metabolic processGO:00421579.7ALB, APOA4
3retinoid metabolic processGO:00015239.5RBP4, APOA4, LRP2
4phototransduction, visible lightGO:00076039.4LRP2, APOA4, RBP4
5small molecule metabolic processGO:00442818.1ALB, PLCE1, FABP1, NAGLU, APOA4, LRP2

Molecular functions related to Proteinuria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fatty acid bindingGO:00055049.3FABP1, ALB
2antioxidant activityGO:00162099.2ALB, FABP1, APOA4
3drug bindingGO:00081448.9ALB, ACE, FABP1
4protein bindingGO:00055156.9ANGPT2, ACE, PLCE1, ALB, RBP4, NPHS1

Products for genes affiliated with Proteinuria

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Proteinuria

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet