MCID: PRT039
MIFTS: 57

Proteinuria malady

Nephrological diseases category

Summaries for Proteinuria

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66Wikipedia, 34MalaCards
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Wikipedia:66 Proteinuria (/pro?ti??n??ri?/ or /pro?ti??nj??ri?/; from protein and urine) means the presence of an... more...

MalaCards: Proteinuria, also known as proteinuria nos, is related to hypertension and nephrosis. An important gene associated with Proteinuria is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Nephrin/Neph1 signaling in the kidney podocyte and Diseases associated with visual transduction. The compounds puromycin aminonucleoside and 1,3-dichloropropene have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are vision/eye and liver/biliary system.

Aliases & Classifications for Proteinuria

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9Disease Ontology, 11DISEASES, 46Novoseek, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

proteinuria 9 11 46
proteinuria nos 9


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Disease Ontology9 DOID:576
ICD9CM28 791.0
NCIt41 C38012
MeSH36 D011507

Related Diseases for Proteinuria

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18GeneCards, 19GeneDecks
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Diseases related to Proteinuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 327)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1UTS2, ACE, ALB, CD79A
2nephrosis30.9NPHS1, NPHS2
3focal segmental glomerulosclerosis30.8PLCE1
4glomerulonephritis30.8CD79A, NPHS2, NPHS1, RBP4, ALB, NAGLU
5glomerulosclerosis30.8ACE, ALB, NPHS1, NPHS2, CD79A
6amyloidosis30.7ALB, RBP4, CD79A
7pre-eclampsia30.7NAGLU, UTS2, ANGPT2, NPHS1, NPHS2
8lupus nephritis30.6CD79A, RBP4, ALB, NAGLU
9nephritis30.6CD79A, NPHS2, NPHS1, RBP4, ALB, ACE
10diabetic nephropathy30.6NAGLU, UTS2, FABP1, ACE, ALB, RBP4
11nephrotic syndrome30.5ALB, PLCE1, ACE, NAGLU, RBP4, NPHS1
12dent's disease30.5LRP2, CLCN5
13fanconi syndrome30.4LRP2, CLCN5
14nephrocalcinosis30.4LRP2, CLCN5, NAGLU
15chronic pyelonephritis30.3NAGLU
16diabetes mellitus30.3CFP, CD79A, NPHS1, RBP4, ALB, ACE
17membranous glomerulonephritis30.3LRP2, ALB, NPHS1, NPHS2, CD79A
18pyelonephritis30.3CD79A, NAGLU
19myeloma30.1NAGLU, ANGPT2, ALB, CD79A
20diabetic retinopathy30.1ALB, ACE, ANGPT2, NAGLU
21lipoid nephrosis30.1NAGLU, ALB, NPHS1, NPHS2, CD79A
22oculocerebrorenal syndrome30.1NAGLU, LRP2
23insulin resistance30.0NPHS1, RBP4, ALB, ACE, UTS2, APOA4
24rheumatoid arthritis30.0LRP2, NAGLU, ANGPT2, CD79A, CTSL
25anuria30.0ACE
26type 1 diabetes mellitus30.0APOA4, NAGLU, ACE, ALB, RBP4, CD79A
27systemic lupus erythematosus29.9CD79A, RBP4, CFP, LRP2
28essential hypertension29.9ALB, ACE, UTS2, NAGLU
29congenital nephrotic syndrome finnish type29.8NPHS1, NPHS2
30type 2 diabetes mellitus29.8APOA4, NAGLU, UTS2, ACE, ALB, RBP4
31congestive heart failure29.8UTS2
32hyperglycemia29.8APOA4, NAGLU, ACE, ALB, NPHS1
33acute poststreptococcal glomerulonephritis29.8CD79A, CFP
34vascular disease29.8ANGPT2
35peripheral vascular disease29.8ALB, CD79A
36membranoproliferative glomerulonephritis29.8CD79A, NPHS1, CFP
37agammaglobulinemia29.8CD79A, CFP
38pneumonia29.7CD79A, RBP4, NAGLU
39iga glomerulonephritis29.7CFP, NAGLU, ACE, ALB, NPHS1, NPHS2
40liver cirrhosis29.7RBP4, ALB, UTS2
41glucose intolerance29.7CD79A, FABP1, APOA4
42atherosclerosis29.6LRP2, APOA4, UTS2, ANGPT2, ACE, ALB
43acute myocardial infarction29.6ACE, ANGPT2, UTS2, NAGLU
44myocardial infarction29.6ACE, UTS2, NAGLU, APOA4
45coronary artery disease29.6ACE, UTS2, APOA4
46kidney disease10.7
47orthostatic proteinuria10.6
48endotheliitis10.4
49obesity10.4
50schistosomiasis10.3

Graphical network of the top 20 diseases related to Proteinuria:



Diseases related to proteinuria

Symptoms for Proteinuria

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Drugs & Therapeutics for Proteinuria

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Proteinuria

Drug clinical trials:

Search ClinicalTrials for Proteinuria

Search NIH Clinical Center for Proteinuria

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Genetic Tests for Proteinuria

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Anatomical Context for Proteinuria

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34MalaCards
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MalaCards organs/tissues related to Proteinuria:

34
Kidney, Endothelial, Testes, Pancreas, Heart, Liver, Bone, T cells, Spinal cord, B cells, Thyroid, Monocytes, Myeloid, Eye, Prostate, Ovary, Lung, Brain, Bone marrow

Animal Models for Proteinuria or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Proteinuria:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3CTSL, RBP4, ANGPT2, NAGLU, LRP2
2MP:00053708.0CTSL, CLCN5, ALB, ACE, FABP1, NAGLU
3MP:00053817.8CTSL, ALB, APOA4, LRP2, ANGPT2
4MP:00053677.6LRP2, CLCN5, NAGLU, ALB, NPHS1, NPHS2
5MP:00053847.3LRP2, ALB, CTSL, CD79A, RBP4, ACE
6MP:00053857.2CFP, APOA4, NAGLU, ANGPT2, PLCE1, RBP4
7MP:00053877.0CFP, APOA4, ANGPT2, CTSL, CD79A, ACE
8MP:00107686.4LRP2, CFP, APOA4, NAGLU, ANGPT2, ACE
9MP:00053765.2ACE, APOA4, CLCN5, ALB, ANGPT2, NPHS1

Publications for Proteinuria

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53PubMed
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Articles related to Proteinuria:

(show top 50)    (show all 1126)
idTitleAuthorsYear
1
Prevalence of hypertension in healthy school children in Pakistan and its relationship with body mass index, proteinuria and hematuria. (24434408)
2014
2
Close association between proteinuria and regulatory T cells in patients with idiopathic nephrotic syndrome. (23263711)
2013
3
Factors related to nephrotic-range proteinuria in late-stage chronic kidney disease patients with diabetes mellitus. (23355027)
2013
4
Hypertension and kidney function in an adult population of West Bengal, India: Role of body weight, waist circumference, proteinuria and rural area living. (23889782)
2013
5
Proteinuria as a risk factor for mortality in patients with colorectal cancer. (23918569)
2013
6
The phosphorus-proteinuria interaction in chronic kidney disease. (23229931)
2013
7
Dasatinib-induced nephrotic-range proteinuria. (23540262)
2013
8
Proteinuria as a risk marker for the progression of chronic kidney disease in patients on predialysis care and the role of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment. (23128440)
2012
9
Simultaneous measurement of urinary albumin and total protein may facilitate decision-making in HIV-infected patients with proteinuria. (22413854)
2012
10
The relation between urinary angiotensinogen and proteinuria in renal AA amyloidosis patients. (22320202)
2012
11
Causes and consequences of proteinuria following kidney transplantation. (21738244)
2011
12
Proteinuria among adult sickle cell anemia patients in Nigeria. (21311153)
2011
13
Urine dipstick to detect trace proteinuria: an underused tool for an underappreciated risk marker. (21684434)
2011
14
Proteinuria in an African HIV-infected patient: effects of telmisartan. (21753253)
2011
15
Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. (21844484)
2011
16
Association between serum soluble TNFI+ receptors and renal dysfunction in type 2 diabetic patients without proteinuria. (21288590)
2011
17
Effect of pentoxifylline on proteinuria, markers of tubular injury and oxidative stress in non-diabetic patients with chronic kidney disease - placebo controlled, randomized, cross-over study. (20309434)
2010
18
The relationship between adiponectin levels and degree of proteinuria in patients with nephrotic and non-nephrotic proteinuria. (19142807)
2009
19
Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients. (18261172)
2008
20
Molecular mechanisms of proteinuria in diabetes. (18793166)
2008
21
Proteinuria: is it all in the foot? (17671644)
2007
22
Desmin as a marker of proteinuria in early stages of membranous nephropathy in elderly patients. (17722705)
2007
23
Effect of renin-angiotensin system in Fabry disease associated proteinuria]. (17397632)
2007
24
Upregulated expression of cardiac ankyrin-repeated protein in renal podocytes is associated with proteinuria severity in lupus nephritis. (17239933)
2007
25
ACE inhibition can improve orthostatic proteinuria associated with nutcracker syndrome. (16902785)
2006
26
Insulin resistance contributes to obesity-related proteinuria. (16020878)
2005
27
Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients. (14747236)
2004
28
A 3-year-old child with proteinuria and nephrocalcinosis. Suspicion of Dent disease. (15365802)
2004
29
Association between polymorphisms of the atrial natriuretic peptide gene and proteinuria: a population-based study. (12687344)
2003
30
Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomerulonephritis. (11981066)
2002
31
High proteinuria selectivity index based upon IgM is a strong predictor of poor renal survival in glomerular diseases. (11427625)
2001
32
Genetic kidney diseases disclose the pathogenesis of proteinuria. (11730159)
2001
33
Effect of fluvastatin on proteinuria in patients with immunoglobulin A nephropathy. (10801253)
2000
34
Induction of microalbuminuria by l-arginine infusion in healthy individuals: an insight into the mechanisms of proteinuria. (10352188)
1999
35
Monitoring of proteinuria in phase I studies in healthy male subjects. (9696951)
1998
36
Mesangial hyperplasia in a patient with renovascular hypertension and proteinuria. (9794597)
1998
37
Proteinuria and tubulointerstitial injury. (9328968)
1997
38
Characterization of proteinuria in primary glomerulonephritides: urinary polymers of albumin. (9292570)
1997
39
Prednisone improves renal function and proteinuria in human immunodeficiency virus-associated nephropathy. (8686713)
1996
40
An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis. (8872972)
1996
41
Hyponatremic hypertensive syndrome and massive proteinuria in a patient with renin-producing leiomyosarcoma. (8023829)
1994
42
Value of fructosamine test in monitoring of diabetes complicated by proteinuria]. (8284241)
1993
43
The effect of enalapril on proteinuria in patients with chronic glomerulonephritis and renal insufficiency. (8139137)
1993
44
High-sensitivity electrophoretic method for the detection of Bence Jones protein and for the study of proteinuria in unconcentrated urines. (7685986)
1993
45
Changes of negative charge on RBC and glomeruli and its relation to the proteinuria of adriamycin nephrosis in rats. (1879220)
1991
46
Clinicopathological study of patients presenting hematuria and proteinuria by renal biopsy]. (2046202)
1991
47
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. (4038407)
1985
48
Effect of praziquantel on hematuria and proteinuria in urinary schistosomiasis. (3938926)
1985
49
Acquired antithrombin III deficiency in patients with glomerular proteinuria. (689489)
1978
50
D-serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis. (1203037)
1975

Variations for Proteinuria

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Expression for genes affiliated with Proteinuria

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proteinuria

Search GEO for disease gene expression data for Proteinuria.

Pathways for genes affiliated with Proteinuria

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Compounds for genes affiliated with Proteinuria

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Proteinuria according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1puromycin aminonucleoside4610.3NPHS1, NPHS2
21,3-dichloropropene4610.3NAGLU, RBP4
3iopentol4610.2NAGLU, ALB
4p-aminohippuric acid4610.2NAGLU, ALB
5tobramycin4610.2NAGLU, RBP4
6perchloroethylene4610.1RBP4, NAGLU
7fructosamine46 2511.0RBP4, ALB, NAGLU
8aminoglycosides469.9LRP2, NAGLU
9cellulose acetate469.9ALB, RBP4, CD79A
10inulin469.9ALB, NAGLU
11vitamin b12469.9CD79A, ALB, LRP2
12indapamide46 1210.8ALB, ACE
13uric acid46 2510.7RBP4, NAGLU, ALB
14perindopril46 52 1211.7NAGLU, ACE, ALB
15enalapril46 52 1211.7ACE, NAGLU, ALB
16thyroxine46 2510.7CD79A, LRP2, ALB, RBP4
17folate469.6ALB, RBP4, CD79A, LRP2
18phosphorus469.6ALB, RBP4, CFP, NAGLU
19furosemide46 62 30 52 25 1214.6ACE, NAGLU, ALB
20dextran sulfate469.6CTSL, CFP, ALB
21ramipril46 1210.6CD79A, ALB, ACE
22aprotinin46 1210.6CTSL, LRP2, NAGLU
23captopril46 62 52 30 1213.6ACE, ALB, CD79A
24warfarin46 52 25 1212.5ACE, ALB, CD79A
25vitamin d469.5CD79A, ALB, NAGLU, LRP2
26gamma globulin469.5CD79A, ALB
27indomethacin46 30 62 1212.5ALB, UTS2, NPHS1, CD79A
28losartan46 52 30 1212.5ACE, ALB, NAGLU
29ascorbic acid46 2510.4CD79A, ALB, RBP4, CFP
30kininogen469.3ACE, CTSL, ALB
31vitamin a46 25 1211.3LRP2, APOA4, NAGLU, RBP4, ALB
32magnesium46 25 1211.3LRP2, NAGLU, RBP4, ALB, CFP
33oleic acid46 30 25 1212.2ALB, FABP1, APOA4
34phospholipid469.1LRP2, APOA4, FABP1, RBP4
35sodium46 2510.0LRP2, NAGLU, UTS2, ACE, ALB
36fibrinogen468.8ANGPT2, APOA4, CD79A, ALB
37cyclosporin a46 30 6210.6CTSL, CD79A, NPHS2, NAGLU, ANGPT2
38heparin46 30 25 1211.4CD79A, ALB, LRP2, CTSL, NAGLU, APOA4
39h2o2468.3CLCN5, NAGLU, UTS2, FABP1, CD79A, ANGPT2
40dexamethasone46 52 30 1211.2CTSL, RBP4, FABP1, ANGPT2, NPHS1, CD79A
41vegf468.0CTSL, NPHS1, CD79A, FABP1, UTS2, ANGPT2
42nitric oxide46 25 1210.0LRP2, NAGLU, ACE, ANGPT2, UTS2
43retinoic acid46 258.9CTSL, NPHS1, RBP4, ANGPT2, FABP1, LRP2
44steroid467.9NPHS2, CTSL, ANGPT2, NAGLU, CD79A, LRP2
45cholesterol46 30 25 1210.7UTS2, ACE, NAGLU, APOA4, LRP2, FABP1
46cysteine467.5RBP4, UTS2, ANGPT2, CFP, ALB, NAGLU
47lipid467.3NPHS1, RBP4, ALB, ACE, FABP1, UTS2
48glucose466.4CTSL, NAGLU, ANGPT2, APOA4, UTS2, FABP1
49calcium46 52 25 129.4ALB, LRP2, CLCN5, ACE, ANGPT2, CTSL
50creatinine465.6NAGLU, CLCN5, NPHS2, NPHS1, RBP4, ALB

GO Terms for genes affiliated with Proteinuria

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17Gene Ontology
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Cellular components related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:0360579.9NPHS1, NPHS2
2lysosomeGO:0057649.4NAGLU, CTSL, LRP2
3protein complexGO:0432349.4RBP4, NPHS2, NPHS1, ALB
4membrane raftGO:0451219.3NPHS1, NPHS2, CD79A
5extracellular vesicular exosomeGO:0700627.8NPHS1, RBP4, ALB, ACE, FABP1, NAGLU
6extracellular spaceGO:0056156.8ACE, CFP, APOA4, UTS2, ANGPT2, ALB
7extracellular regionGO:0055766.8CTSL, CFP, RBP4, ALB, ACE, ANGPT2

Biological processes related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excretionGO:0075889.8NPHS2, NPHS1, CLCN5
2lipoprotein metabolic processGO:0421579.7ALB, APOA4
3retinoid metabolic processGO:0015239.5RBP4, APOA4, LRP2
4phototransduction, visible lightGO:0076039.4LRP2, APOA4, RBP4
5small molecule metabolic processGO:0442818.1ALB, PLCE1, FABP1, NAGLU, APOA4, LRP2

Molecular functions related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fatty acid bindingGO:0055049.3ALB, FABP1
2antioxidant activityGO:0162099.2APOA4, FABP1, ALB
3drug bindingGO:0081448.9FABP1, ACE, ALB
4protein bindingGO:0055156.9PLCE1, CTSL, NPHS2, NPHS1, RBP4, LRP2

Products for genes affiliated with Proteinuria

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Sources for Proteinuria

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet