MCID: PRT039
MIFTS: 51

Proteinuria malady

Summaries for Proteinuria

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64Wikipedia, 33MalaCards
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Wikipedia:64 Proteinuria (/proʊtiːˈnʊəriə/ or /proʊtiːˈnjʊəriə/; from protein and urine) means the... more...

MalaCards: Proteinuria, also known as proteinuria nos, is related to diabetic nephropathy and nephritis. An important gene associated with Proteinuria is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Cell-cell junction organization and Nephrin interactions. The compounds creatinine and calcium have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Aliases & Classifications for Proteinuria

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 57SNOMED-CT, 27ICD9CM, 61UMLS, 40NCIt, 35MeSH
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Aliases & Descriptions:

proteinuria 8 10 45
proteinuria nos 8


External Ids:

Disease Ontology8 DOID:576
ICD9CM27 791.0
NCIt40 C38012
MeSH35 D011507

Related Diseases for Proteinuria

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Proteinuria family:

chronic proteinuria with focal and segmental hyalinosis

Diseases related to Proteinuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 333)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic nephropathy30.9AMBP, CST3, NPHS1, NPHS2, FABP1, RBP4
2nephritis30.8NPHS1, NPHS2, RBP4, CD79A, CFP, ACE
3focal segmental glomerulosclerosis30.7NPHS1, NPHS2, CD79A, ACE, ACTN4, ALB
4nephrosis30.7NPHS1, NPHS2, ACTN4
5amyloidosis30.6SAA4, CST3, RBP4, CD79A, ALB
6lupus nephritis30.6RBP4, CD79A, NAGLU, ALB
7membranous glomerulonephritis30.2NPHS1, NPHS2, CD79A, ALB
8nephrocalcinosis30.2NAGLU, CLCN5
9fanconi syndrome30.2CLCN5
10fabry disease30.2GLA
11insulin resistance30.2ALB, ACE, RBP4, NPHS1
12familial mediterranean fever30.1SAA4
13lipoid nephrosis30.0NPHS1, NPHS2, CD79A, NAGLU, ALB
14arthritis30.0AMBP, SAA4, CTSL, ALB
15colorectal cancer30.0CST3, FABP1, CTSL
16atherosclerosis29.9SAA4, CST3, APOC2, CTSL, RBP4, GLA
17sickle cell disease29.9GLA
18anuria29.9ACE
19cystic fibrosis29.7ALB, CLCN5, RBP4, AMBP
20acute myocardial infarction29.7ACE, NAGLU, CST3, SAA4
21membranoproliferative glomerulonephritis29.6NPHS1, CD79A, CFP
22vascular disease29.6CST3, APOC2, CTSL, ACE
23coronary heart disease29.6CST3, APOC2, ACE
24acute poststreptococcal glomerulonephritis29.6CFP, CD79A
25acute pancreatitis29.6APOC2
26hepatitis c29.6ALB, RBP4
27poems syndrome29.6CD79A
28hypertriglyceridemia29.6APOC2
29agammaglobulinemia29.6CD79A, CFP
30vesicoureteral reflux29.6NAGLU, AMBP
31peripheral vascular disease29.6ACE, ALB
32wilms tumor29.6NPHS1, NPHS2, ACTN4
33orthostatic proteinuria10.6
34n syndrome10.6
35focal glomerulosclerosis10.5
36blood protein disease10.3
37amyloidosis, renal10.3
38urinary schistosomiasis10.2
39amyloidosis, secondary10.2
40nephrosclerosis10.2
41dent's disease10.2
42eclampsia10.2
43immune-complex glomerulonephritis10.2
44alport syndrome10.1
45donnai-barrow syndrome10.1
46adult syndrome10.1
47aminoaciduria10.1
48crescentic glomerulonephritis10.0
49renovascular hypertension10.0
50renal agenesis10.0

Graphical network of the top 20 diseases related to Proteinuria:



Diseases related to proteinuria

Clinical Features for Proteinuria

Drugs & Therapeutics for Proteinuria

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Proteinuria

Search CenterWatch for Proteinuria

Genetic Tests for Proteinuria

Anatomical Context for Proteinuria

Animal Models for Proteinuria or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Proteinuria

Sources:
51PubMed
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Articles related to Proteinuria:

(show top 50)    (show all 1138)
idTitleAuthorsYear
1
Prevalence of hypertension in healthy school children in Pakistan and its relationship with body mass index, proteinuria and hematuria. (24434408)
2014
2
Pathophysiology of proteinuria and its value as an outcome measure in chronic kidney disease. (23441592)
2013
3
Chronic kidney disease: Proteinuria as a predictor of rapid eGFR decline. (24018410)
2013
4
Prolonged PT and aPTT in a patient with severe proteinuria. (23929389)
2013
5
Proteinuria in canine patients with lymphoma. (23278758)
2013
6
Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy. (24049285)
2013
7
Spot urinary protein analysis for excluding significant proteinuria in pregnancy. (23259873)
2013
8
Random urine protein/creatinine ratio readily predicts proteinuria in preeclampsia. (24327974)
2013
9
Podocyte foot process effacement in postreperfusion allograft biopsies correlates with early recurrence of proteinuria in focal segmental glomerulosclerosis. (23917686)
2013
10
Correlation between glomerular filtration rate and urinary N acetyl-beta-D glucosaminidase in children with persistent proteinuria in chronic glomerular disease. (22574074)
2012
11
Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria. (22243792)
2012
12
Early Posttransplant Nephrotic Range Proteinuria as a Presenting Feature of Minimal Change Disease and Acute T Cell-mediated Rejection. (23267783)
2012
13
New options and perspectives for proteinuria management after kidney transplantation. (22137732)
2012
14
Management of proteinuria in clinical practice after kidney transplantation. (22137731)
2012
15
ACE Inhibition in Anti-Thy1 Glomerulonephritis Limits Proteinuria but Does Not Improve Renal Function and Structural Remodeling. (22479264)
2012
16
Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis. (22534961)
2012
17
Antifibrinolytic use during cardiac and hepatic surgery makes tubular proteinuria-based early biomarkers poor tools to diagnose perioperative acute kidney injury. (21601130)
2011
18
No evidence for statin-induced proteinuria in healthy volunteers as assessed by proteomic analysis. (21918593)
2011
19
Imbalance towards Th1 pathway predominance in purpura nephritis with proteinuria. (21922214)
2011
20
Renal vein obstruction and orthostatic proteinuria: a review. (20656752)
2011
21
Proteinuria: measurement and interpretation. (21782142)
2011
22
c-mip impairs podocyte proximal signaling and induces heavy proteinuria. (20484117)
2010
23
Unusual cause of proteinuria and re-renal failure after kidney transplantation: de novo localized AL amyloidosis in renal allograft. (19757136)
2010
24
A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. (20168990)
2010
25
Thiazolidinedione attenuate proteinuria and glomerulosclerosis in Adriamycin-induced nephropathy rats via slit diaphragm protection. (20377774)
2010
26
Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner. (19666118)
2010
27
Clinico-pathological correlations in 127 patients in 11 large pedigrees, segregating one of three heterozygous mutations in the COL4A3/ COL4A4 genes associated with familial haematuria and significant late progression to proteinuria and chronic kidney disease from focal segmental glomerulosclerosis. (19357112)
2009
28
The effect on proteinuria and urinary NAG of treatment with meloxicam in chronic glomerular disease patients--a preliminary study. (19640351)
2009
29
Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients. (18261172)
2008
30
How to measure proteinuria? (18941353)
2008
31
Clinical state of a patient with nephrotic proteinuria successfully treated with combined therapy with angiotensin II receptor antagonists and angiotensin II converting enzyme inhibitors and pentoxifylline]. (18853664)
2008
32
Norcantharidin ameliorates proteinuria, associated tubulointerstitial inflammation and fibrosis in protein overload nephropathy. (18176075)
2008
33
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. (18769366)
2008
34
Low-dose losartan therapy reduces proteinuria in normotensive patients with immunoglobulin A nephropathy. (18971549)
2008
35
Cis and trans regulatory elements in NPHS2 promoter: implications in proteinuria and progression of renal diseases. (16900088)
2006
36
Low-molecular-weight proteinuria in a patient with Lesch-Nyhan syndrome. (15838698)
2005
37
Molecular mechanism responsible for the development of proteinuria: clinical significance of nephrin nephrotic syndrome]. (12924284)
2003
38
Diagnosis of nut-cracker phenomenon using renal Doppler ultrasound in orthostatic proteinuria. (11477164)
2001
39
Albuminuria and proteinuria in hospitalized patients as measured by quantitative and dipstick methods. (11574957)
2001
40
Enalapril and prednisone in children with nephrotic-range proteinuria. (11045392)
2000
41
Risk factors for development of proteinuria in chronic spinal cord injury. (10213646)
1999
42
Megalin knockout mice as an animal model of low molecular weight proteinuria. (10514418)
1999
43
Origin and significance of urinary N-acetyl-beta, D-glucosaminidase (NAG) in renal patients with proteinuria. (8937756)
1996
44
Isosorbide 5 mononitrate administration increases nitric oxide blood levels and reduces proteinuria in IgA glomerulonephritis patients with abnormal urinary endothelin/cyclic GMP ratio. (8556832)
1995
45
Association of angiotensin I-converting enzyme gene polymorphism with susceptibility to antiproteinuric effect of angiotensin I-converting enzyme inhibitors in patients with proteinuria. (8749698)
1995
46
Low molecular weight proteinuria in Chinese herbs nephropathy. (8544416)
1995
47
Leukotriene D4 is a mediator of proteinuria and glomerular hemodynamic abnormalities in passive Heymann nephritis. (8386188)
1993
48
Clinicopathological study of patients presenting hematuria and proteinuria by renal biopsy]. (2046202)
1991
49
Contribution to the aetiopathogenesis of orthostatic proteinuria in children: relation to the upper calyx syndrome. (2744992)
1989
50
Dipyridamole for proteinuria suppression. Use in a patient with proliferative glomerulonephritis. (4406901)
1974

Genetic Variations for Proteinuria

Expression for genes affiliated with Proteinuria

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proteinuria

Search GEO for disease gene expression data for Proteinuria.

Pathways for genes affiliated with Proteinuria

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54Reactome
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Pathways related to Proteinuria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8ACTN4, KIRREL2, NPHS2, NPHS1
210.8ACTN4, KIRREL2, NPHS2, NPHS1

Compounds for genes affiliated with Proteinuria

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Proteinuria according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1creatinine4512.1ALB, LCN1, AMBP, SAA4, CST3, APOC2
2calcium45 50 11 2415.0LCN1, AMBP, SAA4, CST3, NPHS1, NPHS2
3lipid4511.8APOC2, CST3, SAA4, AMBP, LCN1, NPHS1
4glucose4511.6AMBP, SAA4, CST3, APOC2, NPHS1, FABP1
5cysteine4511.6LCN1, AMBP, CST3, APOC2, CTSL, RBP4
6steroid4511.5AMBP, SAA4, CST3, NPHS1, NPHS2, CTSL
7cholesterol45 29 11 2414.5LCN1, SAA4, CST3, APOC2, FABP1, RBP4
8lactate4511.5LCN1, AMBP, CST3, RBP4, GLA, CD79A
9alanine4511.4LCN1, AMBP, CST3, CTSL, RBP4, CD79A
10vitamin a45 11 2413.4LCN1, AMBP, CST3, APOC2, RBP4, NAGLU
11aspartate4511.4AMBP, CST3, CTSL, RBP4, GLA, NAGLU
12urea45 11 2413.3LCN1, AMBP, CST3, RBP4, NAGLU, ALB
13potassium45 11 2413.3LCN1, AMBP, CST3, NAGLU, ACE, ALB
14cyclosporin a45 29 6013.3AMBP, CST3, NPHS2, CTSL, CD79A, NAGLU
15kininogen4511.2AMBP, CST3, CTSL, ACE, ALB
16latex4511.2AMBP, SAA4, CST3, RBP4, NAGLU
17sodium45 2412.2ALB, ACE, NAGLU, CST3, AMBP, LCN1
18homocysteine45 2412.2SAA4, CST3, APOC2, NAGLU, ALB
19sialic acid4511.2AMBP, CST3, RBP4, CD79A, NAGLU
20leucine4511.2NAGLU, GLA, RBP4, CTSL, CST3, AMBP
21hyaluronic acid45 2412.2LCN1, AMBP, CD79A, NAGLU, ALB
22iohexol4511.2AMBP, CST3, NAGLU, ALB
23inulin4511.2AMBP, CST3, NAGLU, ALB
24dexamethasone45 50 29 1114.2NPHS1, FABP1, CTSL, RBP4, CD79A
25ramipril45 1112.2ALB, ACE, CD79A, CST3
26enalapril45 50 1113.2AMBP, NAGLU, ACE, ALB
27polyacrylamide4511.2RBP4, APOC2, SAA4, AMBP, LCN1
28cellulose acetate4511.2ALB, CD79A, RBP4, CST3
29phosphorus4511.1ALB, CFP, NAGLU, RBP4
30captopril45 29 50 60 1115.1CST3, CD79A, ACE, ALB
31heparin45 29 11 2414.1APOC2, CTSL, CD79A, NAGLU, CFP
32uric acid45 2412.1LCN1, SAA4, CST3
33retinoic acid45 2412.1AMBP, APOC2, NPHS1, FABP1, CTSL, RBP4
34methionine4511.1AMBP, CST3, APOC2, FABP1, GLA
35fructosamine45 2412.1ALB, NAGLU, RBP4
36sodium dodecylsulfate4511.0AMBP, APOC2, CD79A, ALB
37fibrinogen4511.0AMBP, SAA4, CST3, CD79A, ALB
38aprotinin45 1112.0AMBP, CTSL, NAGLU
39perindopril45 50 1113.0NAGLU, ACE, ALB
40phospholipid4511.0LCN1, APOC2, FABP1, RBP4, GLA
41lead4511.0AMBP, CTSL, RBP4, NAGLU
42mercury4511.0NAGLU, RBP4, AMBP
43dextran4510.9ALB, GLA, CTSL
441,3-dichloropropene4510.9NAGLU, RBP4
45glutaraldehyde4510.8GLA, CD79A, ALB
46furosemide45 50 60 29 11 2415.7ALB, ACE, NAGLU
47iopentol4510.7ALB, NAGLU
48amikacin4510.6NAGLU, AMBP
4999mtc-dmsa4510.5NAGLU, AMBP
50mannose4510.5CTSL, GLA, CD79A, CFP

GO Terms for genes affiliated with Proteinuria

Sources:
16Gene Ontology
See all sources

Cellular components related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4ALB, LCN1, AMBP, SAA4, CST3, APOC2
2extracellular spaceGO:00561510.9AMBP, CST3, APOC2, RBP4, CFP, ACE
3slit diaphragmGO:03605710.7NPHS1, NPHS2, KIRREL2
4lysosomal lumenGO:04320210.7NAGLU, GLA, CTSL
5protein complexGO:04323410.5NPHS2, RBP4, ACTN4, ALB

Biological processes related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excretionGO:00758810.7CLCN5, NPHS2, NPHS1

Molecular functions related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00814410.7ALB, ACE, FABP1

Products for genes affiliated with Proteinuria

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Sources for Proteinuria

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet