MCID: PRT039
MIFTS: 57

Proteinuria malady

Summaries for Proteinuria

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63Wikipedia, 32MalaCards
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Wikipedia:63 Proteinuria (/proʊtiːˈnʊəriə/ or /proʊtiːˈnjʊəriə/; from protein and urine) means the... more...

MalaCards: Proteinuria, also known as proteinuria nos, is related to hypertension and glomerulonephritis. An important gene associated with Proteinuria is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Cell-cell junction organization and Nephrin interactions. The compounds creatinine and calcium have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Aliases & Classifications for Proteinuria

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8Disease Ontology, 10DISEASES, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 60UMLS, 39NCIt, 34MeSH
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Aliases & Descriptions:

proteinuria 8 10 44
proteinuria nos 8


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Disease Ontology8 DOID:576
ICD9CM27 791.0
NCIt39 C38012
MeSH34 D011507

Related Diseases for Proteinuria

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17GeneCards, 18GeneDecks
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Diseases related to Proteinuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 328)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1CST3, CD79A, ACE, ALB
2glomerulonephritis30.9AMBP, NPHS1, NPHS2, ALB, ACTN4, CFP
3diabetic nephropathy30.9AMBP, CST3, NPHS1, NPHS2, FABP1, RBP4
4nephrotic syndrome30.7NAGLU, CD79A, RBP4, NPHS2, NPHS1, AMBP
5diabetes mellitus30.7AMBP, CST3, APOC2, NPHS1, RBP4, CD79A
6focal segmental glomerulosclerosis30.7NPHS1, NPHS2, CD79A, ACE, ACTN4, ALB
7pre-eclampsia30.6CST3, NPHS1, NPHS2, NAGLU
8amyloidosis30.6SAA4, CST3, RBP4, CD79A, ALB
9obesity30.5RBP4, FABP1, SAA4
10membranous glomerulonephritis30.2NPHS1, NPHS2, CD79A, ALB
11diabetic retinopathy30.2ALB, ACE, NAGLU
12nephrocalcinosis30.2NAGLU, CLCN5
13fanconi syndrome30.2CLCN5
14fabry disease30.2GLA
15peritonitis30.1ALB
16type 2 diabetes mellitus30.1AMBP, CST3, APOC2, NPHS1, RBP4, NAGLU
17pyelonephritis30.1NAGLU, CD79A, AMBP
18chronic pyelonephritis30.1NAGLU
19myeloma30.1ALB, NAGLU, CD79A, CST3
20familial mediterranean fever30.1SAA4
21lipoid nephrosis30.0NPHS1, NPHS2, CD79A, NAGLU, ALB
22rheumatoid arthritis30.0AMBP, SAA4, CST3, CTSL, CD79A, NAGLU
23arthritis30.0AMBP, SAA4, CTSL, ALB
24colorectal cancer30.0CST3, FABP1, CTSL
25iga glomerulonephritis29.8CD79A, GLA, NPHS2, NPHS1, NAGLU, CFP
26atherosclerosis29.8SAA4, CST3, APOC2, CTSL, RBP4, GLA
27essential hypertension29.8CST3, NAGLU, ACE, ALB
28lupus erythematosus29.8CFP, CD79A
29sickle cell disease29.8GLA
30purpura29.8CD79A
31anuria29.8ACE
32chronic kidney failure29.6FABP1, NPHS2, NPHS1, APOC2, CST3, RBP4
33retinal disease29.6AMBP, RBP4, NAGLU, ACE, ALB
34myocardial infarction29.6SAA4, CST3, GLA, NAGLU, ACE
35cystic fibrosis29.6ALB, CLCN5, RBP4, AMBP
36pneumonia29.6SAA4, RBP4, CD79A, NAGLU
37acute myocardial infarction29.6ACE, NAGLU, CST3, SAA4
38membranoproliferative glomerulonephritis29.6NPHS1, CD79A, CFP
39vascular disease29.6CST3, APOC2, CTSL, ACE
40pancreatitis29.6ALB, APOC2
41liver cirrhosis29.6ALB, RBP4
42acute poststreptococcal glomerulonephritis29.6CFP, CD79A
43acute pancreatitis29.6APOC2
44psoriasis29.6CTSL
45inflammatory bowel disease29.6CD79A
46hepatitis c29.6ALB, RBP4
47poems syndrome29.6CD79A
48agammaglobulinemia29.6CD79A, CFP
49vesicoureteral reflux29.6NAGLU, AMBP
50diarrhea29.6CD79A, ALB

Graphical network of the top 20 diseases related to Proteinuria:



Diseases related to proteinuria

Clinical Features for Proteinuria

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Drugs & Therapeutics for Proteinuria

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Proteinuria

Drug clinical trials:

Search ClinicalTrials for Proteinuria

Search NIH Clinical Center for Proteinuria

Search CenterWatch for Proteinuria

Genetic Tests for Proteinuria

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Anatomical Context for Proteinuria

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32MalaCards
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MalaCards organs/tissues related to Proteinuria:

32
Kidney, Endothelial, Testes, Pancreas, Heart, Liver, Bone, T cells, Spinal cord, B cells, Monocytes, Thyroid, Myeloid, Bone marrow, Lung, Eye, Brain, Ovary, Prostate

Animal Models for Proteinuria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Proteinuria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3CTSL, FABP1, NPHS2, NPHS1, CST3, RBP4
2MP:000536711.2ALB, NPHS1, NPHS2, CTSL, GLA, CD79A
3MP:000538511.1NPHS2, RBP4, GLA, NAGLU, PLCE1, CFP
4MP:000537010.7FABP1, CTSL, GLA, NAGLU, CLCN5, ACE

Publications for Proteinuria

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50PubMed
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Articles related to Proteinuria:

(show top 50)    (show all 1137)
idTitleAuthorsYear
1
Urinary gamma-glutamyl transferase-to-creatinine ratio as an indicator of tubular function in Bence Jones Proteinuria. (24392854)
2014
2
Hypertension and kidney function in an adult population of West Bengal, India: Role of body weight, waist circumference, proteinuria and rural area living. (23889782)
2013
3
Random spot urine protein to creatinine ratio is a reliable measure of proteinuria in lupus nephritis in Koreans. (23711154)
2013
4
Proteinuric renal disease in type 2 diabetes-Is remission of proteinuria associated with improved mortality and morbidity? (24380605)
2013
5
A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria. (23364648)
2013
6
Paricalcitol reduces proteinuria but does not modify peritoneal protein loss in patients on peritoneal dialysis. (23364628)
2013
7
Low rate of proteinuria in hypertensives resident in a rural area of Plateau State, Nigeria. (24377205)
2013
8
Effect of enalapril on glomerular filtration rate and proteinuria in children with chronic kidney disease: a randomized controlled trial. (23585423)
2013
9
Reduction and residual proteinuria are therapeutic targets in type 2 diabetes with overt nephropathy: a post hoc analysis (ORIENT-proteinuria). (24013685)
2013
10
Amelioration of circulating lipoprotein profile and proteinuria in a patient with LCAT deficiency due to a novel mutation (Cys74Tyr) in the lid region of LCAT under a fat-restricted diet and ARB treatment. (23522979)
2013
11
Awaiting the OSCAR subanalysis of subjects according to the presence of proteinuria. (24172734)
2013
12
A patient presenting with bilateral lung lesions, pleural effusion, and proteinuria. (23762073)
2013
13
Proteinuria as a risk marker for the progression of chronic kidney disease in patients on predialysis care and the role of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment. (23128440)
2012
14
Resolution of proteinuria in a patient with focal segmental glomerulosclerosis following BiPAP initiation for obesity hypoventilation syndrome. (22185970)
2012
15
Highlights for the management of a child with proteinuria and hematuria. (22844302)
2012
16
Prognostic significance and diagnosis of proteinuria in renal transplantation. (22137730)
2012
17
Associations between healthy lifestyle behaviors and proteinuria and the estimated glomerular filtration rate (eGFR). (22785025)
2012
18
A photo shoot of proteinuria: zebrafish models of inducible podocyte damage. (22581995)
2012
19
A new screening method for proteinuria using Erythrosin B and an automated analyzer--rapid, sensitive and inexpensive determination. (22465201)
2012
20
Disease activity, proteinuria, and vitamin D status in children with systemic lupus erythematosus and juvenile dermatomyositis. (21924736)
2012
21
Urine dipstick to detect trace proteinuria: an underused tool for an underappreciated risk marker. (21684434)
2011
22
Proteinuria in special populations: pregnant women and children. (21782133)
2011
23
Nephrotic proteinuria and renal involvement in HIV-infected children. (22021974)
2011
24
The prevalence of microalbuminuria and proteinuria in cats with diabetes mellitus. (21782146)
2011
25
Undiagnosed hypertension and proteinuria in a market population in Ile-Ife, Nigeria. (22026338)
2011
26
Blood pressure target in chronic kidney disease and proteinuria as an effect modifier. (21810725)
2011
27
Cigarette smoking and the association with glomerular hyperfiltration and proteinuria in healthy middle-aged men. (21885794)
2011
28
Effects of oral paricalcitol on hyperparathyroidism and proteinuria in peritoneal dialysis patients. (22073844)
2011
29
Effects of aggressive approach to the multiple risk factors for diabetic nephro-pathy on proteinuria reduction in diabetes type 2 patients. (19284394)
2009
30
Effect of renin angiotensin system blockade on pentraxin 3 levels in type-2 diabetic patients with proteinuria. (19211665)
2009
31
Nephrotic-range proteinuria in a patient with a giant prolactinoma. (18455849)
2008
32
Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis. (17213874)
2007
33
Microalbuminuria and tubular proteinuria as risk predictors of cardiovascular morbidity and mortality in essential hypertension: final results of a prospective long-term study (MARPLE Study)*. (16467658)
2006
34
The use of a simple algorithm to improve proteinuria diagnosis in clinical laboratories]. (16351475)
2005
35
Tubular and glomerular proteinuria in diagnosing chronic allograft nephropathy with relevance to the degree of urinary albumin excretion. (15848599)
2005
36
Glomerular proteinuria induces heme oxygenase-1 gene expression within renal epithelial cells. (16189191)
2005
37
Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. (14988276)
2004
38
Elevated tissue plasminogen activator as a potential marker of endothelial dysfunction in pre-eclampsia: correlation with proteinuria. (12452463)
2002
39
Transforming growth factor-beta(1) in the kidney and urine of patients with glomerular disease and proteinuria. (12454225)
2002
40
The gelatin-derived plasma substitute Gelofusine causes low-molecular-weight proteinuria by decreasing tubular protein reabsorption. (11689768)
2001
41
Nephrotic-range proteinuria, the major risk factor for early atherosclerosis in juvenile-onset systemic lupus erythematosus. (10857801)
2000
42
Proteinuria: its clinical importance and role in progressive renal disease. (10766008)
2000
43
Nephelometry in the clinical assessment of glomerular proteinuria and tubular function in diabetic nephropathy. (9342486)
1997
44
Left renal vein entrapment syndrome in two girls with orthostatic proteinuria. (9090670)
1997
45
Pentoxifylline reduces proteinuria in insulin-dependent and non insulin-dependent diabetic patients. (7736673)
1995
46
Retinol binding proteinuria and phosphaturia: markers of paracetamol-induced nephrotoxicity. (7979097)
1994
47
Pharmacokinetics and pharmacodynamics of benazepril hydrochloride in patients with major proteinuria. (8359184)
1993
48
Nephronophthisis with massive proteinuria. (6189393)
1983
49
A mouse model of spontaneous renal hypertension. blood pressure, heart weight, kidney weight and proteinuria relationships in NZB x OUW F1 hybrid female mice. (7432814)
1980
50
Fixed and reproducible orthostatic proteinuria. II. Electron microscopy of renal biopsy specimens from five cases. (13742343)
1961

Genetic Variations for Proteinuria

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Expression for genes affiliated with Proteinuria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proteinuria

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Pathways for genes affiliated with Proteinuria

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53Reactome
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Pathways related to Proteinuria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.8ACTN4, KIRREL2, NPHS2, NPHS1
210.8ACTN4, KIRREL2, NPHS2, NPHS1

Compounds for genes affiliated with Proteinuria

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Proteinuria according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1creatinine4412.1ALB, LCN1, AMBP, SAA4, CST3, APOC2
2calcium44 49 11 2415.0LCN1, AMBP, SAA4, CST3, NPHS1, NPHS2
3lipid4411.8APOC2, CST3, SAA4, AMBP, LCN1, NPHS1
4glucose4411.6AMBP, SAA4, CST3, APOC2, NPHS1, FABP1
5cysteine4411.6LCN1, AMBP, CST3, APOC2, CTSL, RBP4
6steroid4411.5AMBP, SAA4, CST3, NPHS1, NPHS2, CTSL
7cholesterol44 28 11 2414.5LCN1, SAA4, CST3, APOC2, FABP1, RBP4
8lactate4411.5LCN1, AMBP, CST3, RBP4, GLA, CD79A
9alanine4411.4LCN1, AMBP, CST3, CTSL, RBP4, CD79A
10vitamin a44 11 2413.4LCN1, AMBP, CST3, APOC2, RBP4, NAGLU
11aspartate4411.4AMBP, CST3, CTSL, RBP4, GLA, NAGLU
12urea44 11 2413.3LCN1, AMBP, CST3, RBP4, NAGLU, ALB
13potassium44 11 2413.3LCN1, AMBP, CST3, NAGLU, ACE, ALB
14cyclosporin a44 28 5913.3AMBP, CST3, NPHS2, CTSL, CD79A, NAGLU
15kininogen4411.2AMBP, CST3, CTSL, ACE, ALB
16latex4411.2AMBP, SAA4, CST3, RBP4, NAGLU
17sodium44 2412.2ALB, ACE, NAGLU, CST3, AMBP, LCN1
18homocysteine44 2412.2SAA4, CST3, APOC2, NAGLU, ALB
19sialic acid4411.2AMBP, CST3, RBP4, CD79A, NAGLU
20leucine4411.2NAGLU, GLA, RBP4, CTSL, CST3, AMBP
21hyaluronic acid44 2412.2LCN1, AMBP, CD79A, NAGLU, ALB
22iohexol4411.2AMBP, CST3, NAGLU, ALB
23inulin4411.2AMBP, CST3, NAGLU, ALB
24dexamethasone44 49 28 1114.2NPHS1, FABP1, CTSL, RBP4, CD79A
25ramipril44 1112.2ALB, ACE, CD79A, CST3
26enalapril44 49 1113.2AMBP, NAGLU, ACE, ALB
27polyacrylamide4411.2RBP4, APOC2, SAA4, AMBP, LCN1
28cellulose acetate4411.2ALB, CD79A, RBP4, CST3
29phosphorus4411.1ALB, CFP, NAGLU, RBP4
30captopril44 28 49 59 1115.1CST3, CD79A, ACE, ALB
31heparin44 28 11 2414.1APOC2, CTSL, CD79A, NAGLU, CFP
32uric acid44 2412.1LCN1, SAA4, CST3
33retinoic acid44 2412.1AMBP, APOC2, NPHS1, FABP1, CTSL, RBP4
34methionine4411.1AMBP, CST3, APOC2, FABP1, GLA
35fructosamine44 2412.1ALB, NAGLU, RBP4
36sodium dodecylsulfate4411.0AMBP, APOC2, CD79A, ALB
37fibrinogen4411.0AMBP, SAA4, CST3, CD79A, ALB
38aprotinin44 1112.0AMBP, CTSL, NAGLU
39perindopril44 49 1113.0NAGLU, ACE, ALB
40phospholipid4411.0LCN1, APOC2, FABP1, RBP4, GLA
41lead4411.0AMBP, CTSL, RBP4, NAGLU
42mercury4411.0NAGLU, RBP4, AMBP
43dextran4410.9ALB, GLA, CTSL
441,3-dichloropropene4410.9NAGLU, RBP4
45glutaraldehyde4410.8GLA, CD79A, ALB
46furosemide44 49 59 28 11 2415.7ALB, ACE, NAGLU
47iopentol4410.7ALB, NAGLU
48amikacin4410.6NAGLU, AMBP
4999mtc-dmsa4410.5NAGLU, AMBP
50mannose4410.5CTSL, GLA, CD79A, CFP

GO Terms for genes affiliated with Proteinuria

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16Gene Ontology
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Cellular components related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4ALB, LCN1, AMBP, SAA4, CST3, APOC2
2extracellular spaceGO:00561510.9AMBP, CST3, APOC2, RBP4, CFP, ACE
3slit diaphragmGO:03605710.7NPHS1, NPHS2, KIRREL2
4lysosomal lumenGO:04320210.7NAGLU, GLA, CTSL
5protein complexGO:04323410.5NPHS2, RBP4, ACTN4, ALB

Biological processes related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excretionGO:00758810.7CLCN5, NPHS2, NPHS1

Molecular functions related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00814410.7ALB, ACE, FABP1

Products for genes affiliated with Proteinuria

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  • Antibodies
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Sources for Proteinuria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet