Proteinuria malady

Wikipedia: Proteinuria (/proʊtiːˈnʊəriə/ or /proʊtiːˈnjʊəriə/; from protein and urine) means the...⁴⁴ more...

MalaCards: Proteinuria, also known as proteinuria nos (context-dependent category), is related to hypertension and focal segmental glomerulosclerosis. An important gene associated with Proteinuria is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are ILK Signaling and Bladder cancer. The compounds arginine and matrigel have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are vision/eye and behavior/neurological.

Aliases & Descriptions:

proteinuria 6 7 8 32 43 proteinuria nos (context-dependent category) 6 proteinuria (context-dependent category) 6

proteinuria (finding) 6 proteinuria nos 6

Diseases related to proteinuria by text searches and GeneDecks gene sharing:

(show top 50)    (show all 952)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	34.3	REN, NOS2, NOS3, ACE, AGT, AGTR1
2	focal segmental glomerulosclerosis	30.9	RBP4, NAGLU, CD79A, CD2AP, ALB, TRPC6
3	congenital nephrotic syndrome finnish type	30.4	VEGFA, KDR, TTR, TF, NPHS1
4	dent disease	29.5	LRP2, REN, CLCN5, CFL1, CUBN
5	hypercalciuria	29.4	LRP2, REN, NAGLU, VDR, CLCN5, B2M
6	type 1 diabetes mellitus	29.3	RBP4, NAGLU, LPA, VDR, LEP, LCAT
7	steroid-resistant nephrotic syndrome	28.6	KIRREL, NAGLU, LMX1B, MYO1E, B2M, CD2AP
8	focal glomerulosclerosis	28.5	REN, CLCN5, FABP1, ALB, ACE, NPHS2
9	hematuria	28.5	NAGLU, CD79A, CD40LG, FN1, INS, AMBP
10	lipoid nephrosis	28.4	NAGLU, CD79A, CD2AP, CCL2, ALB, SPP1
11	renovascular hypertension	28.1	REN, ACE, AGTR1, NPPA, ADM
12	pre-eclampsia	28.1	NOS3, EDN1, EDNRA, AGT
13	nephrosis	28.1	SERPINC1, LAMB2, B2M, MME, APOA1, APOB
14	diabetes, type 2	28.0	INS, IFNA1, ALB, NOS3, ACE, AGT
15	amyloidosis	27.9	VWF, RBP4, SERPINC1, LPA, SDC2, LCAT
16	norum disease	27.8	LCAT, APOA1, APOB, APOE
17	hemorrhagic fever with renal syndrome	27.8	VCAM1, B2M, CD40LG, INS, ICAM1, TNFRSF1B
18	congestive heart failure	27.8	COG2, REN, MME, FN1, IL11, ANGPT2
19	immune-complex glomerulonephritis	27.1	SELP, VCAM1, FTH1, CD40LG, ITGAL, ICAM1
20	membranoproliferative glomerulonephritis type 2	26.9	VCAM1, LCAT, CD79A, ITGAL, CCL2, IFNA1
21	chronic myeloid leukemia	26.8	SELP, FN1, IRF4, IL11, ENG, MAPK14
22	nephrosclerosis	26.8	SERPINC1, SERPINE1, LPA, BMP7, LCAT, INS
23	wilson disease	26.6	NAGLU, B2M, CD79A, APOE, ALB, HMGCR
24	nephrotic syndrome	26.5	LRP2, REN, KIRREL, VWF, RBP4, SELP
25	glomerulopathy	26.2	LRP2, REN, VWF, SELP, NAGLU, BMP6
26	immunodeficiency	26.1	SELL, BMP6, CD79A, CD40LG, ITGAL, INS
27	fabry disease	25.8	VWF, SERPINC1, VDR, VCAM1, APOH, ICAM1
28	peripheral vascular disease	25.8	VWF, SELP, SERPINE1, LPA, VCAM1, CETP
29	type 2 diabetes mellitus	25.6	COG2, VWF, RBP4, SELL, SELP, SERPINE1
30	lipodystrophy	25.3	RBP4, SERPINE1, LPA, LIPA, LEP, CETP
31	leiomyosarcoma	25.3	REN, VEGFA, MME, MMP2, FGF2, CCND1
32	sleep disorder	25.3	VCAM1, LEP, INS, IL8, APOE, ICAM1
33	lupus nephritis	25.2	VWF, RBP4, SERPINE1, NAGLU, VEGFA, VCAM1
34	intermittent claudication	24.9	VWF, SELP, SERPINC1, SERPINE1, B2M, FGF2
35	nephritis	24.9	LRP2, REN, VWF, RBP4, SELP, SERPINE1
36	aldosteronism	24.8	REN, RENBP, SERPINE1, NAGLU, VEGFA, BMP6
37	proliferative diabetic retinopathy	24.7	SELP, SERPINF1, SERPINE1, VEGFA, VCAM1, KDR
38	glomerulonephritis	24.2	LRP2, REN, VWF, RBP4, SELP, SERPINC1
39	familial mediterranean fever	24.1	SELL, SELP, SERPINC1, SERPINE1, VEGFA, LMX1B
40	renal cell carcinoma	23.9	SELP, VEGFA, BMP7, KDR, B2M, ITGA3
41	nephropathy	23.9	LRP2, COG2, REN, RENBP, KIRREL, VWF
42	systemic lupus erythematosus	23.5	LRP2, VWF, RBP4, VCAM1, CD79A, CD40LG
43	sickle cell disease	23.2	VWF, RBP4, SELL, SELP, SERPINE1, VEGFA
44	thrombocytopenia	23.1	VWF, SELL, SELP, SERPINC1, SERPINE1, BMP6
45	hyperlipidemia	23.0	COG2, VWF, RBP4, SELP, SERPINC1, SERPINE1
46	vascular disease	22.6	VWF, SELP, SERPINC1, SERPINE1, VEGFA, LPA
47	twinning	22.4	COG2, REN, VWF, RBP4, SERPINC1, SERPINE1
48	acute pancreatitis	22.1	VWF, SELP, SERPINC1, NAGLU, VEGFA, LEP
49	spinal cord injury	21.8	COG2, REN, SERPINC1, SERPINE1, NAGLU, LEP
50	essential hypertension	21.5	COG2, REN, RENBP, VWF, SELL, SELP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to proteinuria:

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MGI Mouse Phenotypes related to proteinuria:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	vision/eye phenotype	MP:0005391	INF	CTSL1, FGF2, INS, FLT1, MMP2, ITGA3
2	behavior/neurological phenotype	MP:0005386	INF	PRL, CTSL1, , SPP1, , TMEM176B
3	integument phenotype	MP:0010771	INF	, MME, ITGA3, FYN, CFL1, LIPA
4	hematopoietic system phenotype	MP:0005397	INF	ENG, , FGF2, , CD2AP, FTH1
5	no phenotypic analysis	MP:0003012	INF	, IGKC, IFNB1, PTGS2, NR1H4, EDNRB
6	normal phenotype	MP:0002873	INF	CTGF, PTGS2, TNC, HMGCR, ALB, IFNB1
7	growth/size phenotype	MP:0005378	INF	MYH9, ADIPOQ, ADD1, SLC2A1, NPY, NPHS2
8	digestive/alimentary phenotype	MP:0005381	INF	CTGF, VEGFA, SERPINF1, VWF, LRP2, VDR
9	skeleton phenotype	MP:0005390	INF	THBS1, EDNRB, PLAT, CTSL1, , CTGF
10	homeostasis/metabolism phenotype	MP:0005376	INF	MYH9, IFNB1, , FGF2, INS, FLT1
11	cardiovascular system phenotype	MP:0005385	INF	CCL2, CD2AP, FTH1, B2M, LCAT, LEP
12	mortality/aging	MP:0010768	INF	COL4A4, HYOU1, , CCL3, , CCL2
13	craniofacial phenotype	MP:0005382	10.0	TGIF1, EDNRB, EDNRA, EDN1, CFTR, CLCN5
14	respiratory system phenotype	MP:0005388	9.8	LRP2, SELL, SELP, PGF, AGRN, LTC4S
15	embryogenesis phenotype	MP:0005380	9.7	PRL, EDNRB, CUBN, TNFRSF1A, CFL1, SERPINC1
16	adipose tissue phenotype	MP:0005375	7.2	NOS2, NOS3, ACE, ACACB, AGT, TGFB1
17	immune system phenotype	MP:0005387	INF	, KDR, VDR, NAGLU, SELP, SELL
18	other phenotype	MP:0005395	INF	CTSL1, NOS2, NOS3, COL4A3, TGIF1, ADM
19	tumorigenesis	MP:0002006	INF	ADIPOQ, ICAM1, IFNB1, , , CCL2
20	endocrine/exocrine gland phenotype	MP:0005379	INF	, EDNRA, WT1, ITGA3, CD40LG, PAFAH1B1
21	nervous system phenotype	MP:0003631	INF	AGT, , APOA4, , FGF2, INS
22	reproductive system phenotype	MP:0005389	INF	, FYN, B2M, LEP, PAFAH1B1, BMP7
23	liver/biliary system phenotype	MP:0005370	INF	AGT, NOS3, NR1H4, CTSL1, SREBF1, GLA
24	cellular phenotype	MP:0005384	INF	MYH9, ADIPOQ, ADM, SLC2A1, PRKCB, TGIF1
25	renal/urinary system phenotype	MP:0005367	INF	MYH9, ADM, ADD2, NPPA, NPHS2, NPHS1
26	muscle phenotype	MP:0005369	INF	EDN1, WT1, NOS3, NOS2, PLCE1, PLAT
27	hearing/vestibular/ear phenotype	MP:0005377	INF	CTSL1, PLAT, COL4A3, COL4A4, EDN1, EDNRA

Articles related to proteinuria:

(show top 50)    (show all 421)

id	Title	Authors	Year	Affiliating Genes
1	Exome sequencing reveals cubilin mutation as a single -gene cause of proteinuria. (21903995)	Ovunc B.... Hildebrandt F.	2011	CUBN
2	A single nucleotide polymorphism within the acetyl-co enzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. (20168990)	Maeda S.... Nakamura Y.	2010	ACACB
3	Effects of aggressive approach to the multiple risk factors for diabetic nephro-pathy on proteinuria reduction in diabetes type 2 patients. (19284394)	AsciA8-ButuroviA8 B.... KuliA8 M.	2009	ACE, INS
4	Proteinuria in cystic fibrosis: a possible correlatio n between genotype and renal phenotype. (19669005)	Cemlyn-Jones J.... Gamboa F.	2009	CFTR
5	Nephrotic-range proteinuria in a patient with a renal allograft treated with sorafenib for metastatic renal-cell carcinoma. (19381758)	Jonkers I.J.... van Buren M.	2009	VEGFA, CD79A
6	The relationship between adiponectin levels and degree of proteinuria in patients with nephrotic and non-nephrotic proteinuria. (19142807)	Oguz Y.... Vural A.	2009	ADIPOQ, INS
7	Circulating matrix metalloproteinase-2 is an independent correlate of proteinuria in patients with chronic kidney disease. (18701818)	Nagano M.... Okuda S.	2009	MMP2
8	Molecular mechanisms of proteinuria in diabetes. (18793166)	Gnudi L.	2008	TGFB1, SLC2A1
9	Clinical state of a patient with nephrotic proteinuria successfully treated with combined therapy with angiotensin II receptor antagonists and angiotensin II converting enzyme inhibitors and pentoxifylline (18853664)	Renke M.... Rutkowski B.	2008	AGTR1
10	Telmisartan is more effective than losartan in reduci ng proteinuria in patients with diabetic nephropathy. (18496508)	Bakris G.... Koval S.	2008	ALB
11	Nephrotoxicity--proteinuria and hypertension-- (18931564)	Ando M.	2008	NOS3, NPHS1
12	How to measure proteinuria? (18941353)	McIntyre N.J.... Taal M.W.	2008	ALB
13	Prognostic value of the insertion/deletion polymorphism of the ACE gene in type 2 diabetic subjects: results from the Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular events, and Ramipril (DIABHYCAR), Diabete de type 2, Nephropathie et Genetique (DIAB2NEPHROGENE), and Survie, Diabete de type 2 et Genetique (SURDIAGENE) studies: response to Hadjadj et al. (18820224)	Ng D.P.	2008	ACE
14	Assessment of patients' and physicians' compliance to an ACE inhibitor treatment based on urinary N-acetyl Ser-Asp-Lys-Pro determination in the Noninsulin-Dependent Diabetes, Hypertension, Microalbuminuria, Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) study. (16732017)	Azizi M.... Chatellier G.	2006	ACE
15	Molecular mechanisms underlying proteinuria reduction and protection of nephrin and podocytes by ARB (16523969)	Kumagai H.... Saruta T.	2006	NPHS1
16	Blockade of the renin-angiotensin system increases plasma adiponectin levels in type-2 diabetic patients with proteinuria. (15711099)	Yenicesu M.... Vural A.	2005	ADIPOQ
17	The use of a simple algorithm to improve proteinuria diagnosis in clinical laboratories (16351475)	Albaladejo OtA^n M.D.... MartA-nez HernA!ndez P.	2005	AMBP
18	Adiponectin level is reduced and inversely correlated with the degree of proteinuria in type 2 diabetic patients. (16047640)	Yenicesu M.... Vural A.	2005	ADIPOQ
19	Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta 1, and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat. (15526251)	Erman A.... van Dijk D.J.	2004	TGFB1
20	Proteinuria and urinary beta 2-microglobulin as markers of tubular malfunction in the assessment of severity of acute pancreatitis (15117607)	Frasquet J.L.... PAcrez-Mateo M.	2004	B2M
21	Proteinuria predicting outcome in renal disease: nond iabetic nephropathies (REIN). (15485427)	Remuzzi G.... Ruggenenti P.	2004	ACE
22	Relationship between podocyte molecule's distribution and expression, foot process morphology and proteinuria (15100730)	Guan N.... Yang J.Y.	2004	NPHS1, NPHS2
23	Effect of fluvastatin and dipyridamole on proteinuria and renal function in childhood IgA nephropathy with mild histological findings and moderate proteinuria. (12940609)	Kano K.... Arisaka O.	2003	HMGCR
24	Effect of losartan and amlodipine on proteinuria and transforming growth factor-beta1 in patients with IgA nephropathy. (12748343)	Park H.C.... Han D.S.	2003	TGFB1, CD79A
25	Urinary transferrin, high molecular weight proteinuria and the progression of renal disease. (12708564)	Mackinnon B.... Boulton-Jones M.	2003	TF
26	Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis. (12965979)	Jafar T.H.... Levey A.S.	2003	ACE
27	Patterns of nephrin and a new proteinuria-associated protein expression in human renal diseases. (11786094)	Wang S.X.... Holthofer H.	2002	NPHS1
28	High proteinuria selectivity index based upon IgM is a strong predictor of poor renal survival in glomerular diseases. (11427625)	Bakoush O.... Tencer J.	2001	CD40LG
29	Identification of two novel mutations in the CLCN5 gene in Japanese patients with familial idiopathic low molecular weight proteinuria (Japanese Dent's disease). (11136179)	Takemura T.... Yoshioka K.	2001	CLCN5
30	Il-4 therapy prevents the development of proteinuria in active Heymann nephritis by inhibition of Tc1 cells. (11564788)	Spicer S.T.... Hall B.M.	2001	IL4
31	Effect of losartan treatment on the proteinuria in normotensive patients having proteinuria due to secondary amyloidosis. (12166510)	Odabas A.R.... Bilen H.	2001	ALB
32	Long-term effect of angiotensin-converting inhibitors in children with proteinuria (11676896)	Camacho DA-az J.A.... JimAcnez GonzA!lez R.	2001	ACE
33	Proteinuria in a placebo-controlled study of basic fibroblast growth factor for intermittent claudication. (11958389)	Cooper L.T.... Hirsch A.T.	2001	FGF2
34	Urinary excretion of IgG and alpha(1)-microglobulin predicts clinical course better than extent of proteinuria in membranous nephropathy. (11479148)	Bazzi C.... D'amico G.	2001	TF, ALB
35	The gelatin-derived plasma substitute Gelofusine caus es low-molecular-weight proteinuria by decreasing tubular protein reabsorption. (11689768)	en Dam M.A.... Wetzels J.F.	2001	ALB
36	Effect of fluvastatin on proteinuria in patients with immunoglobulin A nephropathy. (10801253)	Buemi M.... Frisina N.	2000	HMGCR
37	Difference between orthostatic and march functional proteinuria by application of stress tolerance test and SDS-PAGE. (10841916)	Korneti P.G.... Korneti B.K.	2000	APOA1
38	Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis. (10589693)	Datta P.K.... Lianos E.A.	1999	HMOX1, NOS2
39	Relationship between glomerular epithelial cell injury and proteinuria in IgA nephropathy (9752687)	Wakai S.... Nihei H.	1998	CR1
40	Serum C-reactive protein is rarely lost into urine in patients with secondary amyloidosis and proteinuria. (9694059)	Laiho K.... Kaarela K.	1998	CRP
41	Plasma and urinary levels of adrenomedullin in chronic glomerulonephritis patients with proteinuria. (9736825)	Kubo A.... Dohi K.	1998	ADM
42	Patterns of dietary intake and serum lipids interact with proteinuria as risk factors for progression of chronic renal failure. (9574466)	Boaz M.... Smetana S.	1998	ALB
43	Renal hemodynamics and proteinuria in chronic glomerulonephritis treated with beta-receptor blockers or ace inhibitors (9280714)	Erley C.M.... Risler T.	1997	ACE
44	Charge and size selectivity of proteinuria in children with idiopathic nephrotic syndrome. (9260234)	Taylor G.M.... Barratt T.M.	1997	ALB
45	Mutations in the CLCN5 gene in Japanese patients with familial idiopathic low-molecular-weight proteinuria. (9328927)	Nakazato H.... Matsuda I.	1997	CLCN5
46	Mechanisms of proteinuria: vascular permeability factor in congenital nephrotic syndrome of the Finnish type. (8910928)	Haltia A.... HolthAPfer H.	1996	KDR, VEGFA
47	Ten-year incidence of gross proteinuria in people with diabetes. (7621997)	Klein R.... Cruickshanks K.J.	1995	INS
48	Leukotriene D4 is a mediator of proteinuria and glomerular hemodynamic abnormalities in passive Heymann nephritis. (8386188)	Katoh T.... Badr K.F.	1993	LTC4S
49	A study on microproteinuria among diabetic and obese subjects without clinically overt proteinuria (1588764)	Hidaka S.	1992	B2M
50	Clinicopathological study of patients presenting hematuria and proteinuria by renal biopsy (2046202)	Shinohara Y.... Hayashida S.	1991	CD79A

Genes related to proteinuria according to GeneCards:

(show top 50)    (show all 143)

id	Symbol	Description	Score	GeneCards Section Context
1	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)	11.0	Publications, Summaries
2	CTSL1	cathepsin L1	11.0	Summaries, Publications
3	PLCE1	phospholipase C, epsilon 1	11.0	Summaries
4	CLCN5	chloride channel, voltage-sensitive 5	11.0	Publications
5	NPHS2	nephrosis 2, idiopathic, steroid-resistant (podocin)	11.0	Publications
6	AMBP	alpha-1-microglobulin/bikunin precursor	11.0	Publications
7	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
8	ACTN4	actinin, alpha 4	11.0	Publications
9	RBP4	retinol binding protein 4, plasma	11.0	Publications
10	CD2AP	CD2-associated protein	11.0	Publications
11	LCN1	lipocalin 1	11.0	Publications
12	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
13	B2M	beta-2-microglobulin	11.0	Publications
14	SYNPO	synaptopodin	11.0	Publications
15	ALB	albumin	11.0	Publications
16	FABP1	fatty acid binding protein 1, liver	11.0	Publications
17	APOC2	apolipoprotein C-II	11.0	Publications
18	PGF	placental growth factor	11.0	Publications
19	KIRREL	kin of IRRE like (Drosophila)	11.0	Publications
20	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
21	COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	11.0	Publications
22	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	11.0	Publications
23	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
24	ANGPT2	angiopoietin 2	11.0	Publications
25	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
26	AGRN	agrin	11.0	Publications
27	CTGF	connective tissue growth factor	11.0	Publications
28	TF	transferrin	11.0	Publications
29	CST3	cystatin C	11.0	Publications
30	LRP2	low density lipoprotein receptor-related protein 2	11.0	Publications
31	HPSE	heparanase	11.0	Publications
32	COL4A4	collagen, type IV, alpha 4	11.0	Publications
33	ADD1	adducin 1 (alpha)	11.0	Publications
34	ADM	adrenomedullin	11.0	Publications
35	APOC3	apolipoprotein C-III	11.0	Publications
36	ENG	endoglin	11.0	Publications
37	CABIN1	calcineurin binding protein 1	11.0	Publications
38	EDNRB	endothelin receptor type B	11.0	Publications
39	GLA	galactosidase, alpha	11.0	Publications
40	APOA4	apolipoprotein A-IV	11.0	Publications
41	COG2	component of oligomeric golgi complex 2	11.0	Publications
42	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Publications
43	REN	renin	11.0	Publications
44	CUBN	cubilin (intrinsic factor-cobalamin receptor)	11.0	Publications
45	HP	haptoglobin	11.0	Publications
46	EDNRA	endothelin receptor type A	11.0	Publications
47	TRPC6	transient receptor potential cation channel, subfamily C, member 6	11.0	Publications
48	LSL	Leptin, serum levels of	11.0	Publications
49	BMP7	bone morphogenetic protein 7	11.0	Publications
50	WT1	Wilms tumor 1	11.0	Publications

Pathways related to proteinuria according to GeneDecks:

(show top 50)    (show all 107)

id	Pathway	Score	Top Affiliating Genes
1	ILK Signaling36	INF	, KDR, BMP7, PGF, FGF2, ACTN4
2	Bladder cancer20	INF	VEGFA, MMP2, IL8, , THBS1, PGF
3	Akt Signaling36	INF	IL11, , IL2RA, ITGAL, IL4, BMP7
4	ECM-receptor interaction20	INF	THBS1, VWF, SDC2, , ITGA3,
5	Inhibition of Angiogenesis by TSP136	INF	, SPP1, COL4A3, MAPK14, FYN, TNC
6	PAK Pathway36	INF	IL8, , FGF2, FLT1, CFL1, BMP7
7	UPA-UPAR Pathway36	INF	COL4A3, , MMP2, COL4A4, ITGAL, ITGA3
8	Antioxidant Action of Vitamin-C36	INF	, IL8, MYH9, PGF, IL2RA, IL11
9	ACE Inhibitor Pathway, Pharmacodynamics34	10.7	AGTR1, NR3C2, MME
10	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.7	MME, NR3C2, NOS3, ACE, AGT, REN
11	Selected targets of HNF110	10.6	APOH, APOB, NR1H4, INS, LPA, APOA1
12	Selected targets of C/EBPalpha10	10.4	CETP, APOB, ALB, TF, ADIPOQ, SERPINC1
13	Statin Pathway, Pharmacodynamics34	10.3	APOB, APOC2, APOA4, LCAT, HMGCR, APOE
14	Regulation of eIF4 and p70S6K36	10.0	ITGA3, ITGAL, IL11, IL4, MAPK14, CCL3
15	Metabolism of lipids and lipoproteins38	9.8	SREBF1, APOB, LCAT, ALOX5, ALB, PTGS2
16	Rheumatoid arthritis20	9.8	PGF, IL11, TGFB1, ITGAL, IL8, FLT1
17	PGC1Alpha Pathway36	9.7	TNFRSF1B, TNFRSF1A, IL4, CCL3, MAPK14, IL8
18	Malaria20	9.5	SELP, SDC2, CD40LG, ITGAL, IL8, THBS1
19	Glucocorticoid Receptor Signaling36	9.4	ANGPT2, MAPK14, TNFRSF1A, IL8, IL4, IL2RA
20	all-trans-Retinoic Acid Signaling in Brain36	9.4	PTGS2, IL4, IL11, BMP6, BMP7, LTC4S
21	Chagas disease (American trypanosomiasis)20	9.2	IL8, MAPK14, CCL2, NOS2, ACE, TGFB1
22	Cytokine-cytokine receptor interaction20	7.4	CD40LG, VEGFA, TNFRSF1B, TNFRSF1A, IFNB1, IFNA2
23	Cell adhesion ECM remodeling10	INF	COL4A3, SERPINE1, SDC2, , IL8, KLK3
24	p70S6K Signaling36	INF	MAPK14, CTGF, TGFB1, PGF, IL4, IL2RA
25	Focal adhesion20	INF	FYN, , , KDR, VWF, FLT1
26	MAPK Family Pathway36	INF	TNFRSF1A, CCL3, CTGF, TGFB1, IL11, PGF
27	Phospholipase-C Pathway36	INF	IL2RA, TNC, SPP1, CTGF, PLCE1, COL4A3
28	Apoptotic Pathways in Synovial Fibroblasts36	INF	FLT1, BMP6, BMP7, KDR, PGF,
29	MAPK Signaling36	INF	MAPK14, FGF2, FLT1, TNFRSF1B, TNFRSF1A, TNC
30	Rho Family GTPases36	INF	SPP1, CTGF, COL4A3, COL4A4, TGFB1, ITGA3
31	p38 Signaling36	INF	CCL2, MAPK14, BMP6, ANGPT2, IL2RA, IL4
32	Rac1 Pathway36	INF	FGF2, ITGAL, ITGA3, CFL1, BMP7, BMP6
33	Angiogenesis3	INF	PTGS2, TGFB1, NOS3, HMOX1, , FGF2
34	Cell adhesion_Plasmin signaling41	INF	VEGFA, KDR, COL4A3, TGFB1, COL4A4, MAPK14
35	Renin-Angiotensin Pathway36	INF	CTGF, FLT1, FGF2, , IL2RA, MAPK14
36	TGF-Beta Pathway36	INF	IL8, ANGPT2, MAPK14, CCL2, CCL3, TNFRSF1A
37	Tec Kinases Signaling36	INF	TNFRSF1A, IL8, IL4, IL2RA, IL11,
38	Cell adhesion_ECM remodeling41	INF	SERPINE1, SDC2, MMP2, , IL8, PLAT
39	ERK Signaling36	INF	, ITGA3, ITGAL, , FLT1,
40	Endothelin-1 Signaling Pathway36	INF	BMP6, EDNRB, BMP7, EDNRA, EDN1, CCL3
41	PTEN Pathway36	INF	COL4A4, TNC, CTGF, COL4A3, IL2RA, PGF
42	Molecular Mechanisms of Cancer36	INF	CTGF, COL4A4, TGFB1, , SPP1, TNFRSF1B
43	Cell adhesion Plasmin signaling10	INF	COL4A3, COL4A4, VEGFA, KDR, FGF2, MAPK14
44	Actin-Based Motility by Rho Family GTPases36	INF	ITGAL, CTGF, PGF, , BMP7
45	Pathways in cancer20	INF	, TGFB1, PRKCB, SLC2A1, NOS2, FGF2
46	JNK Pathway36	INF	, PGF, BMP6, BMP7, KDR, FLT1
47	PPAR Pathway36	INF	MAPK14, PGF, CTGF, TNFRSF1B, TNFRSF1A, IL2RA
48	NF-KappaB Family Pathway36	INF	FYN, FLT1, FGF2, TGFB1, PGF,
49	JAK-STAT Pathway36	INF	PGF, ANGPT2, IL8, IL4, BMP6, IL2RA
50	Transendothelial Migration of Leukocytes36	INF	CCL2, CCL3, ICAM1, TNC, SPP1, COL4A3

Compounds related to proteinuria according to GeneDecks:

(show top 50)    (show all 531)

id	Compound	Score	Top Affiliating Genes
1	arginine32	INF	COG2, REN, VWF, SERPINC1, LPA, VDR
2	matrigel32	INF	VWF, SERPINF1, SERPINE1, VEGFA, VCAM1, BMP6
3	genistein32 9 18 9	INF	SELL, SELP, SERPINE1, VEGFA, VDR, VCAM1
4	lipid32	INF	LRP2, COG2, RBP4, SERPINE1, NAGLU, LPA
5	heparin32 9 18 9	INF	LRP2, COG2, VWF, SERPINF1, SERPINE1, LPA
6	retinoic acid32 42 18	INF	LRP2, VWF, RBP4, SELL, SELP, SERPINF1
7	thymidine32 18	INF	NAGLU, VDR, BMP6, BMP7, KDR, B2M
8	nitroglycerin32 9 9	12.9	COG2, B2M
9	captopril32 42 9 9	13.4	REN, B2M, CD79A, MMP2, APOA1, APOB
10	glucose32	10.3	SERPINF1, BMP7, MME, IL11, ANGPT2, IFNA2
11	cholesterol ester32	10.1	COG2, LPA, LIPA, LCAT, CETP, APOA1
12	vitamin b1232	9.9	LRP2, VWF, LPA, B2M, CD79A, CD40LG
13	sodium nitroprusside32	9.9	REN, VWF, BMP6, MME, HMOX1, EDNRA
14	streptozotocin32	9.6	SERPINF1, NAGLU, KDR, CETP, INS, APOE
15	txb232	9.4	REN, VWF, SELP, NAGLU, LPA, PAFAH1B1
16	perindopril32 34 9 9	12.3	REN, VWF, SERPINE1, NAGLU, VEGFA, ALB
17	oxygen32 18	10.2	RBP4, SERPINF1, NAGLU, SCGB1A1, LCN1, FYN
18	fatty acid32	9.2	COG2, RBP4, LEP, LCAT, FYN, MME
19	aspartate32	9.1	RBP4, SELP, NAGLU, VDR, BMP6, SCGB1A1
20	candesartan32 9 9	11.0	REN, SELP, SERPINE1, VEGFA, MMP2, CCL2
21	arachidonic acid32 9 18 9	11.9	VWF, SELP, LIPA, PAFAH1B1, SCGB1A1, IL11
22	fluvastatin32 34 9 9	11.9	COG2, VWF, SELP, SERPINE1, VCAM1, CETP
23	p00232	8.9	RBP4, LPA, SCGB1A1, LEP, FLT1, APOA4
24	mannitol32 9 9	10.7	SELP, NAGLU, VCAM1, B2M, FTH1, CD40LG
25	azathioprine32 34 9 9	11.6	CD79A, ITGAL, MMP2, IL11, IL2RA, IL4
26	calcitriol32 42 9 18 9	12.6	LRP2, REN, VDR, BMP6, BMP7, B2M
27	hydrocortisone32 9 9	10.4	REN, BMP6, KDR, MMP2, FLT1, INS
28	betacarotene32	8.0	VWF, RBP4, LEP, LCN1, CETP, CD79A
29	chloroquine32 34 9 9	11.0	SERPINC1, BMP6, B2M, CFTR, CD79A, ITGAL
30	alpha tocopherol32	7.7	RBP4, VCAM1, LEP, LCAT, CETP, ITGAL
31	thyroxine32 18	7.5	LRP2, COG2, REN, VWF, RBP4, LPA
32	estrogen32	5.8	COG2, VWF, RBP4, SERPINC1, SERPINE1, LPA
33	polyethylene glycol32	INF	SERPINC1, , APOA1, APOE, IFNA2, HP
34	fmlp32	INF	SELL, SELP, VCAM1, ITGAL, , MAPK14
35	lovastatin32 42 9 9	INF	COG2, LPA, LIPA, CETP, ITGAL, MMP2
36	prostacyclin32	INF	REN, VWF, SELP, SERPINC1, SERPINE1, VEGFA
37	glutamate32	INF	SERPINF1, VDR, BMP6, KDR, LEP, LCAT
38	vitamin d32	INF	LRP2, SERPINE1, NAGLU, VDR, BMP6, BMP7
39	calcium32 9 18 9	INF	COG2, REN, VWF, RBP4, SERPINF1, NAGLU
40	iron32 18	INF	LRP2, COG2, RBP4, NAGLU, SCGB1A1, LCN1
41	pge232	INF	REN, VCAM1, BMP7, CFTR, MME,
42	folate32	INF	LRP2, VWF, RBP4, SERPINC1, LPA, VDR
43	fibrinogen32	INF	COG2, SELP, SERPINC1, SERPINE1, LPA, VCAM1
44	methionine32	INF	VWF, SERPINF1, LPA, LCAT, , APOC2
45	alanine32	INF	COG2, VWF, RBP4, SELL, SERPINC1, NAGLU
46	cyclosporin a32 42	INF	COG2, VWF, SELP, NAGLU, VDR, BMP6
47	cholesterol32 9 18 9	INF	LRP2, COG2, REN, VWF, RBP4, SELP
48	phosphatidylcholine32	INF	LPA, VCAM1, PAFAH1B1, LCAT, CETP, CD79A
49	sialic acid32	INF	RENBP, RBP4, SELL, NAGLU, LPA, CD79A
50	creatinine32	INF	REN, VWF, RBP4, SELL, SELP, SERPINC1

Cellular components related to proteinuria according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	INF	CD40LG, MMP2, , FLT1, INS, FGF2
2	plasma membrane	GO:005886	INF	NOS3, PLCE1, CR1, CTGF, CUBN,
3	extracellular matrix	GO:031012	INF	THBS1, AGRN, PLAT, TNC, APOH,
4	lysosomal lumen	GO:043202	10.2	AGRN, CTSL1, CUBN, HPSE, GLA, SDC2
5	endoplasmic reticulum lumen	GO:005788	10.1	COL4A3, PTGS2, HYOU1, APOB, APOA4, APOA1
6	chylomicron	GO:042627	10.1	APOH, APOE, APOC3, APOC2, APOB, APOA4
7	intermediate-density lipoprotein particle	GO:034363	10.0	APOE, APOC3, APOC2, APOB
8	external side of plasma membrane	GO:009897	9.0	ITGAL, IL4, ENG, ICAM1, ACE, THBS1
9	very-low-density lipoprotein particle	GO:034361	INF	, APOH, APOE, APOC3, APOC2, APOB
10	platelet alpha granule lumen	GO:031093	INF	TGFB1, THBS1, ACTN4, ALB, , VEGFA
11	extracellular region	GO:005576	INF	ADIPOQ, ADM, VWF, FGF2, IL11, IL8
12	high-density lipoprotein particle	GO:034364	INF	, APOH, APOE, APOA4, APOA1, CETP

Biological processes related to proteinuria according to GeneDecks:

(show top 50)    (show all 73)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion	GO:007155	INF	AMBP, ICAM1, TNC, SPP1, COL4A3, THBS1
2	angiogenesis	GO:001525	INF	HMOX1, CTGF, NOS3, , PGF, MYH9
3	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.7	PGF, CCL2, MAPK14, FLT1, KDR, VEGFA
4	positive regulation of cellular protein metabolic process	GO:032270	10.7	ADIPOQ, TGFB1, AGTR1, AGT, INS
5	response to glucose stimulus	GO:009749	10.6	ADIPOQ, TGFB1, THBS1, COL4A3, NR1H4, CTGF
6	kidney development	GO:001822	10.5	AGTR1, AGT, ACE, WT1, MME, BMP6
7	reverse cholesterol transport	GO:043691	10.4	APOE, APOC3, APOC2, APOA4, APOA1, CETP
8	aging	GO:007568	10.4	ADM, TGFB1, AGT, EDNRA, NOS3, HMGCR
9	very-low-density lipoprotein particle remodeling	GO:034372	10.4	APOE, APOC2, APOA4, CETP, LCAT
10	high-density lipoprotein particle remodeling	GO:034375	10.4	APOE, APOC3, APOA4, APOA1, CETP, LCAT
11	cholesterol homeostasis	GO:042632	10.3	APOE, APOC3, APOC2, APOB, APOA4, APOA1
12	lipid metabolic process	GO:006629	10.3	CUBN, SREBF1, ALB, APOE, APOC3, APOC2
13	positive regulation of cholesterol esterification	GO:010873	10.3	AGTR1, AGT, APOE, APOA4, APOA1
14	phospholipid efflux	GO:033700	10.3	APOE, APOC3, APOC2, APOA4, APOA1
15	response to amino acid stimulus	GO:043200	10.2	EDN1, NOS3, CTGF, TNFRSF1A, ICAM1, CCL2
16	negative regulation of angiogenesis	GO:016525	10.1	THBS1, KLK3, COL4A3, CCL2, ANGPT2, APOH
17	cellular response to tumor necrosis factor	GO:071356	9.9	EDN1, ICAM1, CCL3, CCL2, ANKRD1, APOB
18	leukocyte cell-cell adhesion	GO:007159	9.9	ICAM1, APOA4, ITGAL, CD40LG, VCAM1, SELP
19	cell surface receptor signaling pathway	GO:007166	9.8	PRL, AGER, EDNRB, EDN1, COL4A3, CABIN1
20	cellular response to interleukin-1	GO:071347	9.7	EDN1, ICAM1, CCL3, CCL2, ANKRD1, IL8
21	small molecule metabolic process	GO:044281	9.7	HMGCR, HMOX1, HPSE, GLA, ALB, PTGS2
22	negative regulation of blood vessel endothelial cell migration	GO:043537	9.6	TGFB1, THBS1, ANGPT2, APOE, FGF2
23	response to lipopolysaccharide	GO:032496	9.6	ADM, THBD, EDNRA, EDN1, NR1H4, PTGS2
24	negative regulation of inflammatory response	GO:050728	9.6	ADIPOQ, TNFRSF1B, TNFRSF1A, APOE, APOA1, SERPINF1
25	negative regulation of blood coagulation	GO:030195	9.5	THBD, EDN1, APOH, APOE, SERPINE1
26	response to glucocorticoid stimulus	GO:051384	9.5	ADIPOQ, ADM, PLAT, PTGS2, CCL2, LCAT
27	regulation of blood pressure	GO:008217	9.5	NPPA, ACE, EDNRB, NOS3, PTGS2, HMOX1
28	response to nutrient	GO:007584	9.5	ADIPOQ, CUBN, HMGCR, ALOX5, IL4, VCAM1
29	regulation of immune response	GO:050776	9.4	VCAM1, B2M, CD40LG, ITGAL, IL4, IGKC
30	positive regulation of angiogenesis	GO:045766	9.4	TNFRSF1A, NOS3, THBS1, PRKCB, ADM, HMOX1
31	cellular response to lipopolysaccharide	GO:071222	9.2	LTC4S, NOS2, TNFRSF1B, ICAM1, CCL2, ANKRD1
32	female pregnancy	GO:007565	9.2	TGFB1, PRL, NPPA, PGF, ADM, THBD
33	response to hypoxia	GO:001666	9.0	ACTN4, EDNRA, EDN1, NOS3, NOS2, PLAT
34	negative regulation of cell proliferation	GO:008285	8.9	TGIF1, TGFB1, AGT, WT1, COL4A3, NOS3
35	inflammatory response	GO:006954	8.9	TNFRSF1B, PTGS2, PTX3, SPP1, CRP, AGER
36	positive regulation of cell proliferation	GO:008284	INF	ADM, PGF, TGFB1, EDNRA, EDN1, CTGF
37	platelet degranulation	GO:002576	INF	ALB, ACTN4, THBS1, TGFB1, TF, APOA1
38	response to ethanol	GO:045471	INF	ADIPOQ, NOS3, TNFRSF1A, ICAM1, , CCL2
39	response to drug	GO:042493	INF	PTGS2, NOS3, LTC4S, EDN1, THBS1, TGFB1
40	lipoprotein metabolic process	GO:042157	INF	CUBN, ALB, , APOE, APOC3, APOC2
41	organ regeneration	GO:031100	INF	APOH, ANGPT2, CCL2, , TGFB1, ADM
42	blood coagulation	GO:007596	INF	ANGPT2, APOB, APOA1, , ITGAL, ITGA3
43	response to organic cyclic compound	GO:014070	INF	NOS3, CTGF, PTGS2, ICAM1, GPX3,
44	glomerular basement membrane development	GO:032836	INF	NPHS1, WT1, COL4A4, COL4A3,
45	leukocyte migration	GO:050900	INF	MYH9, THBD, ICAM1, ANGPT2, APOB,
46	positive regulation of MAPK cascade	GO:043410	INF	AGT, IL11, , INS, FLT1, LEP
47	response to wounding	GO:009611	INF	ADM, TGFB1, AGER, CTGF, TNC,
48	regulation of cell shape	GO:008360	INF	MYH9, VEGFA, KDR, FYN, , CCL2
49	cholesterol metabolic process	GO:008203	INF	APOC3, APOE, , SREBF1, CUBN, APOB
50	platelet activation	GO:030168	INF	MAPK14, ALB, TRPC6, ACTN4, THBS1, TGFB1

Molecular functions related to proteinuria according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol transporter activity	GO:017127	10.3	APOB, APOA4, APOA1, CETP
2	eukaryotic cell surface binding	GO:043499	10.2	ADIPOQ, TGFB1, THBS1, APOH, APOA4, SELP
3	protein heterodimerization activity	GO:046982	9.7	ADD2, ADD1, PGF, TGFB1, AGTR1, LTC4S
4	antioxidant activity	GO:016209	9.7	ALB, FABP1, APOE, APOA4
5	protease binding	GO:002020	9.6	CST3, TNFRSF1A, INS, SERPINE1, SERPINC1, SELL
6	cytokine activity	GO:005125	9.3	IFNA2, IFNB1, SPP1, EDN1, ADIPOQ, IL4
7	receptor binding	GO:005102	9.3	ADM, NPY, NPPA, NOS2, TNC, GLA
8	hormone activity	GO:005179	9.3	ADIPOQ, ADM, NPPA, PRL, TTR, AGT
9	growth factor activity	GO:008083	9.0	PGF, TGFB1, AGT, CTGF, IL4, IL11
10	protein homodimerization activity	GO:042803	INF	, CUBN, CRP, NOS2, ACTN4, TGFB1
11	lipid binding	GO:008289	INF	LTC4S, PTGS2, , APOH, APOE, APOC2
12	protein binding	GO:005515	INF	, SREBF1, CTSL1, NR1H4, NR3C2, CRP
13	integrin binding	GO:005178	INF	THBS1, ACTN4, CTGF, ICAM1, , KDR
14	heparin binding	GO:008201	INF	APOB, APOE, APOH, CCL2, CTGF, THBS1