MCID: PRT039
MIFTS: 57

Proteinuria malady

Summaries for Proteinuria

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63Wikipedia, 32MalaCards
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Wikipedia:63 Proteinuria (/proʊtiːˈnʊəriə/ or /proʊtiːˈnjʊəriə/; from protein and urine) means the... more...

MalaCards: Proteinuria, also known as proteinuria nos, is related to hypertension and glomerulonephritis. An important gene associated with Proteinuria is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Cell-cell junction organization and Nephrin interactions. The compounds creatinine and calcium have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Aliases & Classifications for Proteinuria

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8Disease Ontology, 10DISEASES, 44Novoseek, 56SNOMED-CT, 27ICD9CM, 60UMLS, 39NCIt, 34MeSH
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Aliases & Descriptions:

proteinuria 8 10 44
proteinuria nos 8


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Disease Ontology8 DOID:576
ICD9CM27 791.0
NCIt39 C38012
MeSH34 D011507

Related Diseases for Proteinuria

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17GeneCards, 18GeneDecks
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Diseases related to Proteinuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 328)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1CST3, CD79A, ACE, ALB
2glomerulonephritis30.9AMBP, NPHS1, NPHS2, ALB, ACTN4, CFP
3diabetic nephropathy30.9AMBP, CST3, NPHS1, NPHS2, FABP1, RBP4
4nephrotic syndrome30.7NAGLU, CD79A, RBP4, NPHS2, NPHS1, AMBP
5diabetes mellitus30.7AMBP, CST3, APOC2, NPHS1, RBP4, CD79A
6focal segmental glomerulosclerosis30.7NPHS1, NPHS2, CD79A, ACE, ACTN4, ALB
7pre-eclampsia30.6CST3, NPHS1, NPHS2, NAGLU
8amyloidosis30.6SAA4, CST3, RBP4, CD79A, ALB
9obesity30.5RBP4, FABP1, SAA4
10membranous glomerulonephritis30.2NPHS1, NPHS2, CD79A, ALB
11diabetic retinopathy30.2ALB, ACE, NAGLU
12nephrocalcinosis30.2NAGLU, CLCN5
13fanconi syndrome30.2CLCN5
14fabry disease30.2GLA
15peritonitis30.1ALB
16type 2 diabetes mellitus30.1AMBP, CST3, APOC2, NPHS1, RBP4, NAGLU
17pyelonephritis30.1NAGLU, CD79A, AMBP
18chronic pyelonephritis30.1NAGLU
19myeloma30.1ALB, NAGLU, CD79A, CST3
20familial mediterranean fever30.1SAA4
21lipoid nephrosis30.0NPHS1, NPHS2, CD79A, NAGLU, ALB
22rheumatoid arthritis30.0AMBP, SAA4, CST3, CTSL, CD79A, NAGLU
23arthritis30.0AMBP, SAA4, CTSL, ALB
24colorectal cancer30.0CST3, FABP1, CTSL
25iga glomerulonephritis29.8CD79A, GLA, NPHS2, NPHS1, NAGLU, CFP
26atherosclerosis29.8SAA4, CST3, APOC2, CTSL, RBP4, GLA
27essential hypertension29.8CST3, NAGLU, ACE, ALB
28lupus erythematosus29.8CFP, CD79A
29sickle cell disease29.8GLA
30purpura29.8CD79A
31anuria29.8ACE
32chronic kidney failure29.6FABP1, NPHS2, NPHS1, APOC2, CST3, RBP4
33retinal disease29.6AMBP, RBP4, NAGLU, ACE, ALB
34myocardial infarction29.6SAA4, CST3, GLA, NAGLU, ACE
35cystic fibrosis29.6ALB, CLCN5, RBP4, AMBP
36pneumonia29.6SAA4, RBP4, CD79A, NAGLU
37acute myocardial infarction29.6ACE, NAGLU, CST3, SAA4
38membranoproliferative glomerulonephritis29.6NPHS1, CD79A, CFP
39vascular disease29.6CST3, APOC2, CTSL, ACE
40pancreatitis29.6ALB, APOC2
41liver cirrhosis29.6ALB, RBP4
42acute poststreptococcal glomerulonephritis29.6CFP, CD79A
43acute pancreatitis29.6APOC2
44psoriasis29.6CTSL
45inflammatory bowel disease29.6CD79A
46hepatitis c29.6ALB, RBP4
47poems syndrome29.6CD79A
48agammaglobulinemia29.6CD79A, CFP
49vesicoureteral reflux29.6NAGLU, AMBP
50diarrhea29.6CD79A, ALB

Graphical network of the top 20 diseases related to Proteinuria:



Diseases related to proteinuria

Clinical Features for Proteinuria

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Drugs & Therapeutics for Proteinuria

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Proteinuria

Drug clinical trials:

Search ClinicalTrials for Proteinuria

Search NIH Clinical Center for Proteinuria

Search CenterWatch for Proteinuria

Genetic Tests for Proteinuria

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Anatomical Context for Proteinuria

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32MalaCards
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MalaCards organs/tissues related to Proteinuria:

32
Kidney, Endothelial, Testes, Pancreas, Heart, Liver, Bone, T cells, Spinal cord, B cells, Thyroid, Monocytes, Myeloid, Eye, Prostate, Ovary, Lung, Brain, Bone marrow

Animal Models for Proteinuria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Proteinuria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3CTSL, FABP1, NPHS2, NPHS1, CST3, RBP4
2MP:000536711.2ALB, NPHS1, NPHS2, CTSL, GLA, CD79A
3MP:000538511.1NPHS2, RBP4, GLA, NAGLU, PLCE1, CFP
4MP:000537010.7FABP1, CTSL, GLA, NAGLU, CLCN5, ACE

Publications for Proteinuria

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50PubMed
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Articles related to Proteinuria:

(show top 50)    (show all 1137)
idTitleAuthorsYear
1
Childhood-onset dense deposit disease: a rare cause of proteinuria. (24338037)
2013
2
Effect of add-on pentoxifylline on proteinuria in membranous glomerulonephritis: a 6-month placebo-controlled trial. (23392759)
2013
3
Alport syndrome: the effects of spironolactone on proteinuria and urinary TGF-I^1. (23748277)
2013
4
Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration. (23048173)
2013
5
Diagnostic utility of urine protein-to-creatinine ratio for identifying proteinuria in pregnancy. (23020712)
2013
6
Rationale and design of an observational study to determine the effects of cholecalciferol on hypertension, proteinuria and urinary MCP-1 in ADPKD. (23971693)
2013
7
Rapamycin ameliorates proteinuria and restores nephrin and podocin expression in experimental membranous nephropathy. (24069045)
2013
8
Shorter bevacizumab infusions do not increase the incidence of proteinuria and hypertension. (23175623)
2013
9
Temporal and spatial expression of podocyte-associated molecules are accompanied by proteinuria in IgA nephropathy rat model. (23173680)
2013
10
Transplantation: Proteinuria in kidney transplantation: an ongoing story. (23545590)
2013
11
Blood pressure targets in chronic kidney disease: does proteinuria dictate how low we go? (23798457)
2013
12
Effects of telmisartan on proteinuria or albuminuria: a meta-analysis of randomized trials. (22560941)
2013
13
Successful treatment with anti-tumor necrosis factor (anti-TNF)-alpha of proteinuria in a patient with familial mediterranean fever (FMF) resistant to colchicine: anti-TNF drugs and FMF. (21431291)
2012
14
Elevated urinary angiotensinogen a marker of intrarenal renin angiotensin system in hypertensive renal transplant recipients: does it play a role in development of proteinuria in hypertensive renal transplant patients? (21923802)
2012
15
Addition of aliskiren to olmesartan ameliorates tubular injury in chronic kidney disease patients partly by reducing proteinuria. (21946392)
2012
16
Proteinuria modifies the effect of systolic blood pressure on total and cardiovascular disease mortality in patients with type 2 diabetes. (22891848)
2012
17
Successful treatment of adult IgA nephropathy with nephrotic-level proteinuria by combination therapy including long-term coadministration of mizoribine. (23197956)
2012
18
Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria. (22859789)
2012
19
Effect of aliskiren on proteinuria in non-diabetic chronic kidney disease: a double-blind, crossover, randomised, controlled trial. (23326865)
2012
20
Aliskiren add-on therapy effectively reduces proteinuria in chronic kidney disease: An open-label prospective trial. (23223162)
2012
21
Mechanisms of the proteinuria induced by Rho GTPases. (22278020)
2012
22
Glcci1 deficiency leads to proteinuria. (21949092)
2011
23
Heavy proteinuria following dengue hemorrhagic fever. (21706936)
2011
24
PIERS proteinuria: relationship with adverse maternal and perinatal outcome. (21846448)
2011
25
Dipstick proteinuria as a screening strategy to identify rapid renal decline. (21807890)
2011
26
Multi-glycoside of Tripterygium wilfordii Hook. f. reduces proteinuria through improving podocyte slit diaphragm dysfunction in anti-Thy1.1 glomerulonephritis. (21570456)
2011
27
Asymptomatic urinary anomalies, hematuria and proteinuria, in patients with inflammatory bowel disease. Preliminary study. (22303602)
2011
28
Nephroquiz 6: a 67-year-old kidney transplant recipient with nephrotic-range proteinuria. (21725188)
2011
29
Treatment of proteinuria with lercanidipine associated with renin-angiotensin axis-blocking drugs. (20199181)
2010
30
The "nutcracker phenomenon" with orthostatic proteinuria: case reports. (16629228)
2006
31
The nail-patella syndrome: rare genetically determined cause of proteinuria]. (18634531)
2006
32
Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients. (15983219)
2005
33
Randomized, controlled study of the effects of losartan versus enalapril in small doses on proteinuria and tubular injury in primary glomerulonephritis. (15795705)
2005
34
Effect of proteinuria on tubulointerstitial damage]. (14587253)
2003
35
Pathogenesis of proteinuria: lessons learned from nephrin and podocin. (12841223)
2003
36
Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition. (12436341)
2002
37
Genetic kidney diseases disclose the pathogenesis of proteinuria. (11730159)
2001
38
Diabetic nephropathy: an epidemiological study based on proteinuria in a population of black African diabetics in Cotonou, Benin]. (11440886)
2001
39
Long-term effect of angiotensin-converting inhibitors in children with proteinuria]. (11676896)
2001
40
Induction of microalbuminuria by l-arginine infusion in healthy individuals: an insight into the mechanisms of proteinuria. (10352188)
1999
41
Serum levels of carnitine, apolipoprotein A I, and apolipoprotein B in children with nephrotic proteinuria. (8897587)
1996
42
Hypercalciuria and nephrocalcinosis in patients with idiopathic low-molecular-weight proteinuria in Japan: is the disease identical to Dent's disease in United Kingdom? (7753256)
1995
43
Symptomatic antiproteinuric treatment decreases serum lipoprotein (a) concentration in patients with glomerular proteinuria. (8052429)
1994
44
Isolated proteinuria in children. Natural history and indications for renal biopsy. (7955787)
1994
45
The effect of enalapril on proteinuria in patients with chronic glomerulonephritis and renal insufficiency. (8139137)
1993
46
Comparative effects of enalapril, atenolol and chlorthalidone on blood pressure and kidney function of diabetic patients affected by arterial hypertension and persistent proteinuria. (1857482)
1991
47
Technetium-99m-MAG3 clearance as a parameter of effective renal plasma flow in patients with proteinuria and lowered serum albumin levels. (1831839)
1991
48
Postural proteinuria and lipoid nephrosis of 58 years' duration. (1009389)
1976
49
Fixed and reproducible orthostatic proteinuria. VI. Results of a 10-year follow-up evaluation. (5454259)
1970
50
Fixed and reproducible orthostatic proteinuria. III. Effect of induced renal hemodynamic alterations upon urinary protein excretion. (13974475)
1963

Genetic Variations for Proteinuria

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Expression for genes affiliated with Proteinuria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Proteinuria

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Pathways for genes affiliated with Proteinuria

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53Reactome
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Pathways related to Proteinuria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.8ACTN4, KIRREL2, NPHS2, NPHS1
210.8ACTN4, KIRREL2, NPHS2, NPHS1

Compounds for genes affiliated with Proteinuria

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Proteinuria according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1creatinine4412.1SAA4, APOC2, AMBP, LCN1, NPHS1, NPHS2
2calcium44 49 11 2415.0ACTN4, ACE, CLCN5, PLCE1, ALB, LCN1
3lipid4411.8NPHS1, AMBP, NAGLU, ALB, ACE, SAA4
4glucose4411.6APOC2, AMBP, SAA4, CST3, NPHS1, FABP1
5cysteine4411.6AMBP, CST3, APOC2, CTSL, RBP4, NAGLU
6steroid4411.5AMBP, SAA4, CST3, NPHS1, NPHS2, CTSL
7cholesterol44 28 11 2414.5CST3, LCN1, ACE, FABP1, NAGLU, RBP4
8lactate4411.5NAGLU, CST3, AMBP, LCN1, RBP4, GLA
9alanine4411.4ALB, LCN1, AMBP, CST3, CTSL, RBP4
10vitamin a44 11 2413.4ALB, NAGLU, RBP4, APOC2, CST3, AMBP
11aspartate4411.4CST3, RBP4, CTSL, AMBP, GLA, ALB
12urea44 11 2413.3NAGLU, RBP4, CST3, AMBP, LCN1, ALB
13potassium44 11 2413.3ACE, ALB, AMBP, CST3, NAGLU, LCN1
14cyclosporin a44 28 5913.3CTSL, CD79A, NAGLU, NPHS2, CST3, AMBP
15kininogen4411.2ALB, AMBP, CST3, ACE, CTSL
16latex4411.2AMBP, RBP4, CST3, SAA4, NAGLU
17sodium44 2412.2ALB, AMBP, LCN1, CST3, NAGLU, ACE
18homocysteine44 2412.2SAA4, CST3, APOC2, NAGLU, ALB
19sialic acid4411.2AMBP, CST3, RBP4, CD79A, NAGLU
20leucine4411.2NAGLU, GLA, RBP4, AMBP, CST3, CTSL
21hyaluronic acid44 2412.2CD79A, AMBP, LCN1, NAGLU, ALB
22iohexol4411.2AMBP, CST3, NAGLU, ALB
23inulin4411.2AMBP, CST3, NAGLU, ALB
24dexamethasone44 49 28 1114.2CD79A, RBP4, CTSL, FABP1, NPHS1
25ramipril44 1112.2ALB, CST3, CD79A, ACE
26enalapril44 49 1113.2NAGLU, ACE, ALB, AMBP
27polyacrylamide4411.2LCN1, AMBP, SAA4, APOC2, RBP4
28cellulose acetate4411.2RBP4, ALB, CD79A, CST3
29phosphorus4411.1ALB, RBP4, NAGLU, CFP
30captopril44 28 49 59 1115.1CD79A, CST3, ALB, ACE
31heparin44 28 11 2414.1CFP, NAGLU, CD79A, CTSL, APOC2
32uric acid44 2412.1LCN1, SAA4, CST3
33retinoic acid44 2412.1NPHS1, APOC2, CD79A, AMBP, RBP4, FABP1
34methionine4411.1FABP1, GLA, CST3, AMBP, APOC2
35fructosamine44 2412.1ALB, RBP4, NAGLU
36sodium dodecylsulfate4411.0AMBP, APOC2, CD79A, ALB
37fibrinogen4411.0CD79A, ALB, SAA4, CST3, AMBP
38aprotinin44 1112.0AMBP, CTSL, NAGLU
39perindopril44 49 1113.0NAGLU, ALB, ACE
40phospholipid4411.0LCN1, APOC2, FABP1, RBP4, GLA
41lead4411.0AMBP, CTSL, RBP4, NAGLU
42mercury4411.0RBP4, NAGLU, AMBP
43dextran4410.9ALB, GLA, CTSL
441,3-dichloropropene4410.9RBP4, NAGLU
45glutaraldehyde4410.8ALB, GLA, CD79A
46furosemide44 49 59 28 11 2415.7NAGLU, ACE, ALB
4799mtc-dmsa4410.7NAGLU, AMBP
48iopentol4410.6ALB, NAGLU
49amikacin4410.5NAGLU, AMBP
50mannose4410.5GLA, CTSL, CD79A, CFP

GO Terms for genes affiliated with Proteinuria

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16Gene Ontology
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Cellular components related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4ALB, LCN1, AMBP, SAA4, CST3, APOC2
2extracellular spaceGO:00561510.9AMBP, CST3, APOC2, RBP4, CFP, ACE
3slit diaphragmGO:03605710.7NPHS1, NPHS2, KIRREL2
4lysosomal lumenGO:04320210.7NAGLU, GLA, CTSL
5protein complexGO:04323410.5NPHS2, RBP4, ACTN4, ALB

Biological processes related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excretionGO:00758810.7CLCN5, NPHS2, NPHS1

Molecular functions related to Proteinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00814410.7ALB, ACE, FABP1

Products for genes affiliated with Proteinuria

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  • Antibodies
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Sources for Proteinuria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet