MCID: PRT005
MIFTS: 38

Protoplasmic Astrocytoma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Protoplasmic Astrocytoma

MalaCards integrated aliases for Protoplasmic Astrocytoma:

Name: Protoplasmic Astrocytoma 12 55 14 69
Protoplasmic Astrocytic Tumor 12
Astrocytoma Protoplasmic 51

Characteristics:

Orphanet epidemiological data:

55
protoplasmic astrocytoma
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7008
MeSH 41 D001254
NCIt 46 C4320
SNOMED-CT 64 55094006
Orphanet 55 ORPHA251598
UMLS via Orphanet 70 C0334580
ICD10 via Orphanet 33 C71.9
UMLS 69 C0334580

Summaries for Protoplasmic Astrocytoma

MalaCards based summary : Protoplasmic Astrocytoma, also known as protoplasmic astrocytic tumor, is related to fibrillary astrocytoma and astrocytoma, and has symptoms including sensory manifestations, motor manifestations and seizures. An important gene associated with Protoplasmic Astrocytoma is PTGS2 (Prostaglandin-Endoperoxide Synthase 2), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Development HGF signaling pathway. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are neoplasm and vision/eye

Related Diseases for Protoplasmic Astrocytoma

Diseases related to Protoplasmic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 31.3 GFAP IDH2 TP53
2 astrocytoma 10.4
3 oligoastrocytoma 10.2 GFAP IDH2
4 gemistocytic astrocytoma 10.1 GFAP IDH2
5 intracranial chondrosarcoma 10.0 IDH2 TP53
6 glioma susceptibility 1 10.0 IDH2 TP53
7 epilepsy 10.0
8 bile duct adenocarcinoma 9.9 IDH2 TP53
9 balanitis xerotica obliterans 9.9 PTGS2 TP53
10 bladder squamous cell carcinoma 9.9 PTGS2 TP53
11 esophagus adenocarcinoma 9.9 PTGS2 TP53
12 cerebral primitive neuroectodermal tumor 9.9 SRC TP53
13 uterine carcinosarcoma 9.9 PTGS2 TP53
14 signet ring cell adenocarcinoma 9.9 SRC TP53
15 esophageal disease 9.9 PTGS2 TP53
16 keratocystic odontogenic tumor 9.9 PTGS2 TP53
17 barrett's adenocarcinoma 9.9 PTGS2 TP53
18 frontal convexity meningioma 9.9 GFAP TP53
19 gastrointestinal system benign neoplasm 9.9 PTGS2 TP53
20 gliofibroma 9.9 GFAP TP53
21 cerebral convexity meningioma 9.9 GFAP TP53
22 intestinal benign neoplasm 9.9 PTGS2 TP53
23 cellular ependymoma 9.9 GFAP TP53
24 central nervous system primitive neuroectodermal neoplasm 9.9 GFAP TP53
25 cerebral neuroblastoma 9.9 GFAP TP53
26 mixed glioma 9.9 GFAP TP53
27 spinal cancer 9.9 GFAP TP53
28 chordoid glioma 9.9 GFAP TP53
29 ependymoblastoma 9.9 GFAP TP53
30 cerebral ventricle cancer 9.9 GFAP TP53
31 ovarian serous carcinoma 9.9 PTGS2 TP53
32 cerebrum cancer 9.9 GFAP TP53
33 supratentorial cancer 9.9 GFAP TP53
34 actinic keratosis 9.9 PTGS2 TP53
35 malignant ependymoma 9.9 GFAP TP53
36 pleomorphic xanthoastrocytoma 9.9 GFAP TP53
37 cervical adenocarcinoma 9.9 PTGS2 TP53
38 gliomatosis cerebri 9.8 GFAP TP53
39 gastroesophageal reflux 9.8 PTGS2 TP53
40 papilloma of choroid plexus 9.8 GFAP TP53
41 spinal cord astrocytoma 9.8 GFAP TP53
42 choroid plexus cancer 9.8 GFAP TP53
43 colorectal adenoma 9.8 PTGS2 TP53
44 necrotizing sialometaplasia 9.8 GFAP TP53
45 cystic teratoma 9.8 GFAP TP53
46 cerebellar liponeurocytoma 9.8 GFAP TP53
47 esophagitis 9.8 PTGS2 TP53
48 ductal carcinoma in situ 9.8 PTGS2 TP53
49 medullomyoblastoma 9.8 GFAP TP53
50 ureteral obstruction 9.8 PTGS2 TP53

Graphical network of the top 20 diseases related to Protoplasmic Astrocytoma:



Diseases related to Protoplasmic Astrocytoma

Symptoms & Phenotypes for Protoplasmic Astrocytoma

UMLS symptoms related to Protoplasmic Astrocytoma:


sensory manifestations, motor manifestations, seizures, headache

MGI Mouse Phenotypes related to Protoplasmic Astrocytoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 IDH2 PTGS2 SRC TP53
2 vision/eye MP:0005391 8.92 GFAP PTGS2 SRC TP53

Drugs & Therapeutics for Protoplasmic Astrocytoma

Drugs for Protoplasmic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5
Serotonin Phase 3 50-67-9 5202
6 Serotonin Agents Phase 3
7 Serotonin Antagonists Phase 3
8 Gastrointestinal Agents Phase 3
9 Neurotransmitter Agents Phase 3
10 Histamine Antagonists Phase 3
11 Histamine H1 Antagonists Phase 3
12 Anti-Allergic Agents Phase 3
13 Antipruritics Phase 3
14
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Protein Kinase Inhibitors Phase 1, Phase 2
16
Verteporfin Approved, Investigational Phase 1 129497-78-5
17
Trioxsalen Approved Phase 1 3902-71-4 5585
18 Dihematoporphyrin Ether Phase 1
19 Photosensitizing Agents Phase 1
20
Dopamine Approved 51-61-6, 62-31-7 681
21 Fluorides
22 Dihydroxyphenylalanine
23 Dopamine Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
4 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
5 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Protoplasmic Astrocytoma

Genetic Tests for Protoplasmic Astrocytoma

Anatomical Context for Protoplasmic Astrocytoma

MalaCards organs/tissues related to Protoplasmic Astrocytoma:

38
Brain

Publications for Protoplasmic Astrocytoma

Articles related to Protoplasmic Astrocytoma:

# Title Authors Year
1
Diffuse central nervous system protoplasmic astrocytoma. ( 20049933 )
2010
2
Cyclooxygenase-2, Bcl-2, and chromosome 1p analysis in protoplasmic astrocytomas. ( 15017587 )
2004
3
Protoplasmic astrocytoma. A clinicopathologic study of 16 tumors. ( 7785654 )
1995
4
Protoplasmic astrocytoma: cytologic features on tissue imprint preparation. ( 1638945 )
1992
5
Protoplasmic astrocytoma: an angiographic case report. ( 5544526 )
1971
6
Epilepsy incident to protoplasmic astrocytoma; report of a case. ( 18115670 )
1949

Variations for Protoplasmic Astrocytoma

Expression for Protoplasmic Astrocytoma

Search GEO for disease gene expression data for Protoplasmic Astrocytoma.

Pathways for Protoplasmic Astrocytoma

GO Terms for Protoplasmic Astrocytoma

Cellular components related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 PTGS2 SRC

Biological processes related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.7 PTGS2 SRC TP53
2 positive regulation of apoptotic process GO:0043065 9.61 PTGS2 SRC TP53
3 response to drug GO:0042493 9.58 PTGS2 SRC TP53
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.54 SRC TP53
5 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.51 PTGS2 SRC
6 response to cytokine GO:0034097 9.49 PTGS2 TP53
7 cellular response to UV GO:0034644 9.48 PTGS2 TP53
8 cellular response to heat GO:0034605 9.46 PTGS2 TP53
9 response to organonitrogen compound GO:0010243 9.37 PTGS2 TP53
10 cellular response to reactive oxygen species GO:0034614 9.32 SRC TP53
11 response to fatty acid GO:0070542 9.26 PTGS2 SRC
12 cellular response to fluid shear stress GO:0071498 9.16 PTGS2 SRC
13 negative regulation of telomerase activity GO:0051974 8.96 SRC TP53
14 cellular response to hypoxia GO:0071456 8.8 PTGS2 SRC TP53

Molecular functions related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 8.96 GFAP SRC
2 enzyme binding GO:0019899 8.8 PTGS2 SRC TP53

Sources for Protoplasmic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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