MCID: PRT005
MIFTS: 29

Protoplasmic Astrocytoma malady

Categories: Neuronal diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Protoplasmic Astrocytoma

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 65UMLS, 47Novoseek, 36MeSH, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Protoplasmic Astrocytoma:

Name: Protoplasmic Astrocytoma 10 12 51 65
Protoplasmic Astrocytic Tumor 10
 
Astrocytoma Protoplasmic 47

Characteristics:

Orphanet epidemiological data:

51
protoplasmic astrocytoma:
Inheritance: Not applicable; Age of onset: Childhood

Classifications:



External Ids:

Disease Ontology10 DOID:7008
MeSH36 D001254
NCIt42 C4320
SNOMED-CT59 55094006
Orphanet51 251598
UMLS via Orphanet66 C0334580
UMLS65 C0334580

Summaries for Protoplasmic Astrocytoma

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MalaCards based summary: Protoplasmic Astrocytoma, also known as protoplasmic astrocytic tumor, is related to fibrillary astrocytoma and cystic fibrosis. An important gene associated with Protoplasmic Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways are Small cell lung cancer and Signaling mediated by p38-alpha and p38-beta. Affiliated tissues include brain, and related mouse phenotypes are tumorigenesis and skeleton.

Related Diseases for Protoplasmic Astrocytoma

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Diseases related to Protoplasmic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1fibrillary astrocytoma11.7
2cystic fibrosis10.3
3respiratory failure10.3
4chlamydia10.3
5trachoma10.3
6astrocytoma10.3
7oligodactyly tetramelic postaxial10.2GFAP, IDH2
8mixed astrocytoma-ependymoma10.0IDH2, TP53
9cervical verrucous carcinoma10.0PTGS2, TP53
10basophilic carcinoma10.0PTGS2, TP53
11colonic l-cell glucagon-like peptide producing tumor10.0SRC, TP53
12mediastinal neurilemmoma10.0PTGS2, TP53
13autosomal dominant complex spastic paraplegia type 9a10.0PTGS2, TP53
14adult central nervous system mixed germ cell tumor10.0PTGS2, TP53
15central nervous system childhood germ cell tumor10.0PTGS2, TP53
16biliary tract neoplasm10.0PTGS2, TP53
17ulnar neuropathy10.0PTGS2, TP53
18alveoli adenoma9.9GFAP, TP53
19molluscum contagiosum9.9PTGS2, TP53
20pineal gland astrocytoma9.9GFAP, TP53
21syphilis9.9GFAP, TP53
22ovarian clear cell carcinoma9.9PTGS2, TP53
23cerebellar medulloblastoma9.9GFAP, TP53
24childhood infratentorial neoplasm9.9GFAP, TP53
25lateral ventricle meningioma9.9GFAP, TP53
26connective tissue benign neoplasm9.9PTGS2, TP53
27space motion sickness9.9GFAP, TP53
28adult choroid plexus cancer9.9GFAP, TP53
29subependymal giant cell astrocytoma9.9GFAP, TP53
30prostate colloid adenocarcinoma9.9PTGS2, TP53
31eye disease9.9GFAP, TP53
32lung benign neoplasm9.9GFAP, TP53
33pilocytic astrocytoma of cerebellum9.9GFAP, TP53
34estrogen-receptor positive breast cancer9.9PTGS2, TP53
35melanotic neuroectodermal tumor9.9GFAP, TP53
36myxopapillary ependymoma9.9GFAP, TP53
37primary thrombocytopenia9.9PTGS2, TP53
38mucocele of salivary gland9.9GFAP, TP53
39cerebral ventricle cancer9.9GFAP, TP53
40salivary gland adenoid cystic carcinoma9.9GFAP, TP53
41nasopharyngeal carcinoma9.9GFAP, TP53
42organ system benign neoplasm9.9PTGS2, TP53
43adult medulloblastoma9.9GFAP, TP53
44head and neck carcinoma9.9GFAP, TP53
45common variable immunodeficiency9.9PTGS2, TP53
46small intestine leiomyosarcoma9.9GFAP, TP53
47childhood pilocytic astrocytoma9.9GFAP, TP53
48postmenopausal atrophic vaginitis9.9PTGS2, TP53
49lipoma of the rectum9.9GFAP, TP53
50brain stem ependymoma9.9GFAP, TP53

Graphical network of the top 20 diseases related to Protoplasmic Astrocytoma:



Diseases related to protoplasmic astrocytoma

Symptoms for Protoplasmic Astrocytoma

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Drugs & Therapeutics for Protoplasmic Astrocytoma

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Drugs for Protoplasmic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CyproheptadineapprovedPhase 315129-03-32913
Synonyms:
1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine
1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
129-03-3
4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine
4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine
4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine
4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine
41354-29-4
5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
5-20-08-00500 (Beilstein Handbook Reference)
AC1L1ER8
AKOS004119847
Axoprol
BIDD:GT0324
BPBio1_000096
BPBio1_000155
BRD-K28143534-001-01-4
BRD-K28143534-003-03-6
BRN 1685976
BSPBio_000086
Biomol-NT_000131
C06935
CAS-969-33-5
CCRIS 5232
CHEBI:4046
CHEMBL516
CID2913
CYPROHEPTADINE
Ciproheptadina
Ciproheptadina [INN-Spanish]
Ciprovit
Ciprovit (TN)
Cypoheptadine
Cyproheptadiene
Cyproheptadin
Cyproheptadine
Cyproheptadine (INN)
 
Cyproheptadine Hcl
Cyproheptadine Hydrochloride
Cyproheptadine [INN:BAN]
Cyproheptadinum
Cyproheptadinum [INN-Latin]
D07765
DB00434
Dibenzosuberonone/Cyproheptadine
Dihexazin
Dronactin
EINECS 204-928-9
Eiproheptadine
Glutodina
HMS2090P20
HSDB 3048
L001016
LS-114933
Lopac-C-6022
Lopac0_000246
MK 141
MolPort-002-507-777
NCGC00015252-01
NCGC00015252-02
NCGC00015252-03
NCGC00015252-09
NCGC00024293-02
NCGC00024293-04
NCGC00024293-05
Oprea1_498140
PDSP1_001229
PDSP2_001213
Periactin
Periactine
Periactinol
Prestwick0_000103
Prestwick1_000103
Prestwick2_000103
Prestwick3_000103
SPBio_002025
STK802098
Tocris-0996
UNII-2YHB6175DO
Viternum
nchembio.559-comp10
2
Histamine PhosphateapprovedPhase 390651-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
EINECS 200-118-4
 
H0147
Histamine Positive Skin Test Control
Histamine Positive skin test control
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
3Neurotransmitter AgentsPhase 314795
4
SerotoninPhase 3314750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
5Anti-Allergic AgentsPhase 31312
6Serotonin AntagonistsPhase 31175
7Histamine H1 AntagonistsPhase 3688
8Serotonin AgentsPhase 32668
9Histamine AntagonistsPhase 3826
10Dermatologic AgentsPhase 34555
11AntipruriticsPhase 3619
12
histaminePhase 390675614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
13Gastrointestinal AgentsPhase 36401
14
CrizotinibapprovedPhase 1, Phase 292877399-52-511626560, 10366136, 10366137, 10366138, 10366139, 10366140, 10366141
Synonyms:
(R)-Crizotinib
C-Met/HGFR Tyrosine Kinase Inhibitor PF-02341066
C-Met/Hepatocyte Growth Factor Receptor Tyrosine Kinase Inhibitor PF-02341066
Crizotinib
Crizotinibum
 
MET Tyrosine Kinase Inhibitor PF-02341066
PF 2341066
PF-02341066
PF-2341066
Xalkori
crizotinib
15Protein Kinase InhibitorsPhase 1, Phase 23162
16
TrioxsalenapprovedPhase 1403902-71-45585
Synonyms:
2',4,8-Trimethylpsoralen
4,5',8-Trimethylpsoralen
4,8,5'-Trimethylpsoralen
6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone
Trimethylpsoralen
Trioxisaleno
 
Trioxsalen
Trioxysalen
Trioxysalene
Trioxysalenum
Trisoralen
trimethylpsoralen
trioxysalen
trisoralen
17
Verteporfinapproved, investigationalPhase 183129497-78-55362420
Synonyms:
Verteporfin
Verteporfina
 
Verteporfinum
Vert├ęporfine
Visudyne
18Dihematoporphyrin EtherPhase 140
19
Octreotideapproved, investigational19883150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
 
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Ocphyl
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide acetate
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatin
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
20Edotreotide20
21Radiopharmaceuticals362
22Fluorides364
23Dihydroxyphenylalanine123

Interventional clinical trials:

idNameStatusNCT IDPhase
1Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for CancerTerminatedNCT01132547Phase 3
2Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell LymphomaActive, not recruitingNCT00939770Phase 1, Phase 2
3Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or LymphomaCompletedNCT01273090Phase 1
4Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain TumorsRecruitingNCT00002647Phase 1
5Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain TumorsSuspendedNCT02194452
618F FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly Diagnosed or Recurrent GliomasTerminatedNCT02175745

Search NIH Clinical Center for Protoplasmic Astrocytoma

Genetic Tests for Protoplasmic Astrocytoma

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Anatomical Context for Protoplasmic Astrocytoma

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MalaCards organs/tissues related to Protoplasmic Astrocytoma:

33
Brain

Animal Models for Protoplasmic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Protoplasmic Astrocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3IDH2, PTGS2, SRC, TP53
2MP:00053908.2IDH2, PTGS2, SRC, TP53
3MP:00053918.0GFAP, PTGS2, SRC, TP53

Publications for Protoplasmic Astrocytoma

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Articles related to Protoplasmic Astrocytoma:

idTitleAuthorsYear
1
ADP-ribosylation factor-like 4C (ARL4C), a novel ovarian cancer metastasis suppressor, identified by integrated genomics. (25901194)
2015
2
Sex and the clinical value of body mass index in patients with clear cell renal cell carcinoma. (24002606)
2013
3
Gene expression profiling of human macrophages at late time of infection with Mycobacterium tuberculosis. (16895554)
2006
4
Keratinocyte growth factor regulates proliferation and differentiation of hematopoietic cells expressing the receptor gene K-sam. (11937263)
2002
5
Regulation of the functional interaction between cyclin D1 and the estrogen receptor. (11073968)
2000
6
Why radiographs are useful in evaluation of neonates suspected of having congenital syphilis. (1535874)
1992

Variations for Protoplasmic Astrocytoma

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Expression for genes affiliated with Protoplasmic Astrocytoma

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Search GEO for disease gene expression data for Protoplasmic Astrocytoma.

GO Terms for genes affiliated with Protoplasmic Astrocytoma

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Biological processes related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to fatty acidGO:00705429.7PTGS2, SRC
2cellular response to fluid shear stressGO:00714989.4PTGS2, SRC
3cellular response to UVGO:00346449.2PTGS2, TP53
4positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.8SRC, TP53

Molecular functions related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:00199019.1SRC, TP53

Sources for Protoplasmic Astrocytoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet