MCID: PRT005
MIFTS: 35

Protoplasmic Astrocytoma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Protoplasmic Astrocytoma

MalaCards integrated aliases for Protoplasmic Astrocytoma:

Name: Protoplasmic Astrocytoma 12 56 14 69
Protoplasmic Astrocytic Tumor 12
Astrocytoma Protoplasmic 52

Characteristics:

Orphanet epidemiological data:

56
protoplasmic astrocytoma
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7008
MeSH 42 D001254
NCIt 47 C4320
SNOMED-CT 64 55094006
Orphanet 56 ORPHA251598
UMLS via Orphanet 70 C0334580
ICD10 via Orphanet 34 C71.9
UMLS 69 C0334580

Summaries for Protoplasmic Astrocytoma

MalaCards based summary : Protoplasmic Astrocytoma, also known as protoplasmic astrocytic tumor, is related to fibrillary astrocytoma and omphalomesenteric cyst, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Protoplasmic Astrocytoma is PTGS2 (Prostaglandin-Endoperoxide Synthase 2), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Development HGF signaling pathway. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are neoplasm and vision/eye

Related Diseases for Protoplasmic Astrocytoma

Diseases related to Protoplasmic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
id Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 11.0
2 omphalomesenteric cyst 10.3 GFAP IDH2
3 ovarian mucinous cystadenofibroma 10.3 GFAP IDH2
4 astrocytoma 10.3
5 mixed oligodendroglioma-astrocytoma 10.1 IDH2 TP53
6 congenital disorder of glycosylation, type if 10.1 IDH2 TP53
7 peritoneal serous adenocarcinoma 10.0 IDH2 TP53
8 villous adenocarcinoma 10.0 PTGS2 TP53
9 esophagus squamous cell carcinoma 10.0 PTGS2 TP53
10 vulvar keratoacanthoma-like carcinoma 10.0 SRC TP53
11 pancreatic signet ring cell adenocarcinoma 9.9 SRC TP53
12 rectum kaposi's sarcoma 9.9 PTGS2 TP53
13 frontal sinus schneiderian papilloma 9.9 PTGS2 TP53
14 schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma 9.9 PTGS2 TP53
15 oral antidiabetic drugs toxicity or dose selection 9.9 PTGS2 TP53
16 gastrointestinal neuroendocrine tumor 9.9 PTGS2 TP53
17 pancoast tumor 9.9 GFAP TP53
18 brain stem astrocytic neoplasm 9.9 GFAP TP53
19 maxillary neoplasm 9.9 PTGS2 TP53
20 renal pelvis urothelial papilloma 9.9 GFAP TP53
21 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 9.9 GFAP TP53
22 brain glioma 9.9 GFAP TP53
23 rh isoimmunization 9.9 GFAP TP53
24 iodine hypothyroidism 9.9 GFAP TP53
25 third cranial nerve disease 9.9 GFAP TP53
26 pleural empyema 9.9 GFAP TP53
27 cervical neuroblastoma 9.9 PTGS2 TP53
28 aggressive systemic mastocytosis 9.9 GFAP TP53
29 childhood choroid plexus cancer 9.9 GFAP TP53
30 brachial plexus neuritis 9.9 GFAP TP53
31 fasciolopsiasis 9.9 PTGS2 TP53
32 subependymal giant cell astrocytoma 9.9 GFAP TP53
33 pineoblastoma 9.9 GFAP TP53
34 epilepsy 9.9
35 fallopian tube mucinous tumor 9.9 PTGS2 TP53
36 gliofibroma 9.9 GFAP TP53
37 lymphopenia 9.9 GFAP TP53
38 conjunctival concretion 9.9 PTGS2 TP53
39 prostate adenoid cystic carcinoma 9.9 GFAP TP53
40 cataract 24, anterior polar 9.9 GFAP TP53
41 plasmodium ovale malaria 9.9 GFAP TP53
42 retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities 9.9 PTGS2 TP53
43 atypical choroid plexus papilloma 9.9 GFAP TP53
44 pacinian tumor 9.9 GFAP TP53
45 large intestine lipoma 9.9 GFAP TP53
46 congenital hypomyelination neuropathy 9.9 PTGS2 TP53
47 peritoneal benign neoplasm 9.9 GFAP TP53
48 malignant struma ovarii 9.8 PTGS2 TP53
49 melanotic medulloblastoma 9.8 GFAP TP53
50 estrogen-receptor negative breast cancer 9.8 PTGS2 TP53

Graphical network of the top 20 diseases related to Protoplasmic Astrocytoma:



Diseases related to Protoplasmic Astrocytoma

Symptoms & Phenotypes for Protoplasmic Astrocytoma

UMLS symptoms related to Protoplasmic Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

MGI Mouse Phenotypes related to Protoplasmic Astrocytoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 IDH2 PTGS2 SRC TP53
2 vision/eye MP:0005391 8.92 GFAP PTGS2 SRC TP53

Drugs & Therapeutics for Protoplasmic Astrocytoma

Drugs for Protoplasmic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Dermatologic Agents Phase 3,Phase 1
4 Anti-Allergic Agents Phase 3
5 Antipruritics Phase 3
6 Gastrointestinal Agents Phase 3
7 Histamine Antagonists Phase 3
8 Histamine H1 Antagonists Phase 3
9
Histamine Phosphate Phase 3 51-74-1 65513
10 Neurotransmitter Agents Phase 3
11
Serotonin Phase 3 50-67-9 5202
12 Serotonin Agents Phase 3
13 Serotonin Antagonists Phase 3
14
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Protein Kinase Inhibitors Phase 1, Phase 2
16
Trioxsalen Approved Phase 1 3902-71-4 5585
17
Verteporfin Approved, Investigational Phase 1 129497-78-5
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
19
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
20
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
21 Dihematoporphyrin Ether Phase 1
22 Photosensitizing Agents Phase 1
23 Micronutrients Phase 1
24 Nicotinic Acids Phase 1
25 Trace Elements Phase 1
26 Vitamin B Complex Phase 1
27 Vitamins Phase 1
28 Folate Nutraceutical Phase 1
29 Vitamin B3 Nutraceutical Phase 1
30 Vitamin B9 Nutraceutical Phase 1
31
Dopamine Approved 51-61-6, 62-31-7 681
32 Dihydroxyphenylalanine
33 Dopamine Agents
34 Fluorides

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
4 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
5 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Protoplasmic Astrocytoma

Genetic Tests for Protoplasmic Astrocytoma

Anatomical Context for Protoplasmic Astrocytoma

MalaCards organs/tissues related to Protoplasmic Astrocytoma:

39
Brain

Publications for Protoplasmic Astrocytoma

Articles related to Protoplasmic Astrocytoma:

id Title Authors Year
1
Diffuse central nervous system protoplasmic astrocytoma. ( 20049933 )
2010
2
Cyclooxygenase-2, Bcl-2, and chromosome 1p analysis in protoplasmic astrocytomas. ( 15017587 )
2004
3
Protoplasmic astrocytoma. A clinicopathologic study of 16 tumors. ( 7785654 )
1995
4
Protoplasmic astrocytoma: cytologic features on tissue imprint preparation. ( 1638945 )
1992
5
Protoplasmic astrocytoma: an angiographic case report. ( 5544526 )
1971
6
Epilepsy incident to protoplasmic astrocytoma; report of a case. ( 18115670 )
1949

Variations for Protoplasmic Astrocytoma

Expression for Protoplasmic Astrocytoma

Search GEO for disease gene expression data for Protoplasmic Astrocytoma.

Pathways for Protoplasmic Astrocytoma

GO Terms for Protoplasmic Astrocytoma

Cellular components related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 PTGS2 SRC

Biological processes related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.5 PTGS2 SRC TP53
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 SRC TP53
3 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.43 PTGS2 SRC
4 negative regulation of apoptotic process GO:0043066 9.4 SRC TP53
5 cellular response to UV GO:0034644 9.37 PTGS2 TP53
6 response to fatty acid GO:0070542 9.26 PTGS2 SRC
7 cellular response to fluid shear stress GO:0071498 9.16 PTGS2 SRC
8 negative regulation of telomerase activity GO:0051974 8.96 SRC TP53
9 cellular response to hypoxia GO:0071456 8.8 PTGS2 SRC TP53

Molecular functions related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.8 PTGS2 SRC TP53
2 kinase binding GO:0019900 8.65 SRC

Sources for Protoplasmic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....