MCID: PRT005
MIFTS: 36

Protoplasmic Astrocytoma malady

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Protoplasmic Astrocytoma

Aliases & Descriptions for Protoplasmic Astrocytoma:

Name: Protoplasmic Astrocytoma 12 56 14 69
Protoplasmic Astrocytic Tumor 12
Astrocytoma Protoplasmic 52

Characteristics:

Orphanet epidemiological data:

56
protoplasmic astrocytoma
Inheritance: Not applicable; Age of onset: Childhood;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7008
MeSH 42 D001254
NCIt 47 C4320
SNOMED-CT 64 55094006
Orphanet 56 ORPHA251598
UMLS via Orphanet 70 C0334580
ICD10 via Orphanet 34 C71.9
UMLS 69 C0334580

Summaries for Protoplasmic Astrocytoma

MalaCards based summary : Protoplasmic Astrocytoma, also known as protoplasmic astrocytic tumor, is related to fibrillary astrocytoma and astrocytoma, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Protoplasmic Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Development HGF signaling pathway. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are neoplasm and vision/eye

Related Diseases for Protoplasmic Astrocytoma

Diseases related to Protoplasmic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
id Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 11.2
2 astrocytoma 10.3
3 ophn1 syndrome 10.1 GFAP IDH2
4 bronchial mucus gland adenoma 10.1 GFAP IDH2
5 acquired hemangioma 10.0 PTGS2 TP53
6 urethral verrucous carcinoma 10.0 PTGS2 TP53
7 reactive arthritis 10.0 PTGS2 TP53
8 testis refractory cancer 10.0 IDH2 TP53
9 cystinosis, nephropathic 10.0 IDH2 TP53
10 tamoxifen-related endometrial lesion 10.0 PTGS2 TP53
11 ovarian mucinous neoplasm 10.0 PTGS2 TP53
12 statin toxicity 10.0 PTGS2 TP53
13 ideomotor apraxia 10.0 PTGS2 TP53
14 advanced sleep phase syndrome 10.0 PTGS2 TP53
15 gallbladder signet ring cell adenocarcinoma 10.0 SRC TP53
16 mitochondrial encephalomyopathy 10.0 PTGS2 TP53
17 childhood brain germinoma 10.0 SRC TP53
18 extra-adrenal pheochromocytoma 10.0 PTGS2 TP53
19 fallopian tube adenocarcinoma 10.0 PTGS2 TP53
20 liver fibrosarcoma 10.0 GFAP TP53
21 cervical adenoid cystic carcinoma 10.0 GFAP TP53
22 hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10.0 PTGS2 TP53
23 bronchitis 10.0 GFAP TP53
24 alpha chain disease 10.0 PTGS2 TP53
25 cervical benign neoplasm 10.0 GFAP TP53
26 clear cell meningioma 10.0 GFAP TP53
27 basophilic carcinoma 10.0 IDH2 TP53
28 paternal uniparental disomy of chromosome 1 10.0 GFAP TP53
29 vulvar benign neoplasm 10.0 GFAP TP53
30 porokeratosis 10.0 GFAP TP53
31 conjunctival concretion 10.0 PTGS2 TP53
32 adult brainstem gliosarcoma 10.0 GFAP TP53
33 middle ear disease 10.0 GFAP TP53
34 blood group incompatibility 10.0 GFAP TP53
35 mast-cell sarcoma 10.0 GFAP TP53
36 olfactory neuroblastoma 10.0 GFAP TP53
37 mixed epithelial stromal tumour 10.0 GFAP TP53
38 demyelinating polyneuropathy 10.0 PTGS2 TP53
39 childhood embryonal testis carcinoma 10.0 GFAP TP53
40 pineoblastoma 10.0 GFAP TP53
41 brain stem astrocytic neoplasm 10.0 GFAP TP53
42 childhood choroid plexus cancer 10.0 GFAP TP53
43 congenital symblepharon 10.0 PTGS2 TP53
44 brain oligodendroglioma 10.0 GFAP TP53
45 cutaneous adenocystic carcinoma 10.0 GFAP TP53
46 arthus reaction 10.0 GFAP TP53
47 childhood central nervous system primitive neuroectodermal neoplasm 10.0 GFAP TP53
48 pancreatic cancer 10.0 GFAP TP53
49 plasmodium ovale malaria 10.0 GFAP TP53
50 pacinian tumor 10.0 GFAP TP53

Graphical network of the top 20 diseases related to Protoplasmic Astrocytoma:



Diseases related to Protoplasmic Astrocytoma

Symptoms & Phenotypes for Protoplasmic Astrocytoma

UMLS symptoms related to Protoplasmic Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

MGI Mouse Phenotypes related to Protoplasmic Astrocytoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 IDH2 PTGS2 SRC TP53
2 vision/eye MP:0005391 8.92 GFAP PTGS2 SRC TP53

Drugs & Therapeutics for Protoplasmic Astrocytoma

Drugs for Protoplasmic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5
Serotonin Phase 3 50-67-9 5202
6 Serotonin Agents Phase 3
7 Serotonin Antagonists Phase 3
8 Gastrointestinal Agents Phase 3
9 Neurotransmitter Agents Phase 3
10 Histamine Antagonists Phase 3
11 Histamine H1 Antagonists Phase 3
12 Anti-Allergic Agents Phase 3
13 Antipruritics Phase 3
14
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Protein Kinase Inhibitors Phase 1, Phase 2
16
Verteporfin Approved, Investigational Phase 1 129497-78-5
17
Trioxsalen Approved Phase 1 3902-71-4 5585
18
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
19
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
21 Dihematoporphyrin Ether Phase 1
22 Photosensitizing Agents Phase 1
23 Nicotinic Acids Phase 1
24 Trace Elements Phase 1
25 Vitamin B Complex Phase 1
26 Vitamins Phase 1
27 Micronutrients Phase 1
28 Folate Nutraceutical Phase 1
29 Vitamin B3 Nutraceutical Phase 1
30 Vitamin B9 Nutraceutical Phase 1
31
Dopamine Approved 51-61-6, 62-31-7 681
32 Fluorides
33 Dihydroxyphenylalanine
34 Dopamine Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
2 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1
4 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1
5 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Protoplasmic Astrocytoma

Genetic Tests for Protoplasmic Astrocytoma

Anatomical Context for Protoplasmic Astrocytoma

MalaCards organs/tissues related to Protoplasmic Astrocytoma:

39
Brain

Publications for Protoplasmic Astrocytoma

Articles related to Protoplasmic Astrocytoma:

id Title Authors Year
1
Diffuse central nervous system protoplasmic astrocytoma. ( 20049933 )
2010
2
Cyclooxygenase-2, Bcl-2, and chromosome 1p analysis in protoplasmic astrocytomas. ( 15017587 )
2004
3
Protoplasmic astrocytoma. A clinicopathologic study of 16 tumors. ( 7785654 )
1995
4
Protoplasmic astrocytoma: cytologic features on tissue imprint preparation. ( 1638945 )
1992
5
Protoplasmic astrocytoma: an angiographic case report. ( 5544526 )
1971
6
Epilepsy incident to protoplasmic astrocytoma; report of a case. ( 18115670 )
1949

Variations for Protoplasmic Astrocytoma

Expression for Protoplasmic Astrocytoma

Search GEO for disease gene expression data for Protoplasmic Astrocytoma.

Pathways for Protoplasmic Astrocytoma

GO Terms for Protoplasmic Astrocytoma

Cellular components related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 PTGS2 SRC

Biological processes related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.5 PTGS2 SRC TP53
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 SRC TP53
3 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.4 PTGS2 SRC
4 cellular response to UV GO:0034644 9.37 PTGS2 TP53
5 response to fatty acid GO:0070542 9.26 PTGS2 SRC
6 negative regulation of telomerase activity GO:0051974 9.16 SRC TP53
7 cellular response to fluid shear stress GO:0071498 8.96 PTGS2 SRC
8 cellular response to hypoxia GO:0071456 8.8 PTGS2 SRC TP53

Molecular functions related to Protoplasmic Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.8 PTGS2 SRC TP53

Sources for Protoplasmic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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