MCID: PRR013
MIFTS: 39

Prurigo Nodularis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Prurigo Nodularis

MalaCards integrated aliases for Prurigo Nodularis:

Name: Prurigo Nodularis 49 51 69

Classifications:



External Ids:

ICD10 32 L28.1
UMLS 69 C0263353

Summaries for Prurigo Nodularis

NIH Rare Diseases : 49 Prurigo nodularis (PN) is a skin disease in which hard, crusty, intensely itchy lumps form on the skin. The itching is so intense that people scratch themselves to the point of bleeding or pain. The hard lumps range in size from very small to about an half inch across and have a rough, dry top. There may be a few or hundreds. The lumps tend to be located on the outer parts of the arms, shoulders and legs. The trunk, face and even palms can also be affected. Repetitive rubbing, scratching, and touching could possibly result in more skin lesions. The itching is worsened by heat, sweating, or irritation from clothing. The exact cause is unknown. PN, in some cases, can be seen with other diseases such as atopic dermatitis (eczema), lymphoma, chronic autoimmune cholestatic hepatitis, HIV infection, severe anemia, or a chronic kidney disease-related itching known as uremic pruritus. Treatment is very difficult and may include steroids corticosteroids, antihistamines, and other medication such as thalidomide or Lenalidomide. In some cases, cryotherapy, photochemotherapy, or habit reversal therapy to break the itch-scratch cycle has improved the symptoms. PN can last for many years, and the itching is so intense that the disease may affect the person's ability to perform and enjoy everyday activities. Last updated: 11/2/2017

MalaCards based summary : Prurigo Nodularis is related to dermatitis and lymphoma. An important gene associated with Prurigo Nodularis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Phospholipase-C Pathway and p70S6K Signaling. The drugs Nalbuphine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and tonsil.

Wikipedia : 72 Prurigo nodularis (PN), also known as nodular prurigo, is a skin disease characterised by pruritic... more...

Related Diseases for Prurigo Nodularis

Diseases related to Prurigo Nodularis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 dermatitis 10.3
2 lymphoma 10.2
3 keratoacanthoma 10.2
4 hepatitis 10.2
5 tonsillitis 10.2
6 bullous pemphigoid 10.2
7 neuropathy 10.2
8 cough variant asthma 10.1 NGF RNASE3
9 conjunctival nevus 10.1 NGF RNASE3
10 ocular cicatricial pemphigoid 10.1 NGF RNASE3
11 ocular dominance 10.1 NGF NGFR
12 anhidrosis 10.1 NGF NGFR
13 lichen planus 10.1
14 neurodermatitis 10.1
15 lymphoma, hodgkin, classic 10.1
16 uremia 10.1
17 vitiligo-associated multiple autoimmune disease susceptibility 1 10.1
18 herpes zoster 10.1
19 keratoconjunctivitis 10.1 NGF RNASE3
20 rhinitis 10.0 NGF RNASE3
21 diabetic neuropathy 10.0 NGF NGFR
22 vasomotor rhinitis 9.9 RNASE3 TAC1
23 gastric cancer 9.9
24 psoriasis 9.9
25 psoriasis 13 9.9
26 contact dermatitis 9.9
27 amyloidosis 9.9
28 burns 9.9
29 allergic contact dermatitis 9.9
30 hashimoto thyroiditis 9.9
31 hemangioma 9.9
32 cytomegalic inclusion disease 9.9
33 ige responsiveness, atopic 9.9
34 igg4-related disease 9.9
35 celiac disease 1 9.9
36 porokeratosis 9.9
37 linear iga disease 9.9
38 colitis 9.9
39 pustulosis of palm and sole 9.9
40 endotheliitis 9.9
41 dermatitis herpetiformis, familial 9.9
42 collagenous colitis 9.9
43 macular amyloidosis 9.9
44 psoriasis 2 9.9
45 thyroiditis 9.9
46 generalized eruptive keratoacanthoma 9.9
47 lymphoma, non-hodgkin, familial 9.9
48 filariasis 9.9
49 peritonitis 9.9
50 psoriasis 7 9.9

Graphical network of the top 20 diseases related to Prurigo Nodularis:



Diseases related to Prurigo Nodularis

Symptoms & Phenotypes for Prurigo Nodularis

Drugs & Therapeutics for Prurigo Nodularis

Drugs for Prurigo Nodularis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nalbuphine Approved Phase 2, Phase 3 20594-83-6 5311304 5360630
2 Peripheral Nervous System Agents Phase 2, Phase 3
3 Analgesics Phase 2, Phase 3
4 Central Nervous System Depressants Phase 2, Phase 3
5 Narcotic Antagonists Phase 2, Phase 3
6 Narcotics Phase 2, Phase 3
7 Analgesics, Opioid Phase 2, Phase 3
8 Antipruritics Phase 2, Phase 3
9
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
10
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
11
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 17753757 6447131
12
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
13
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
14
Substance P Investigational Phase 2 33507-63-0 44359816
15 Serlopitant Investigational Phase 2 860642-69-9
16 Neurotransmitter Agents Phase 2
17 neurokinin A Phase 2
18 Neurokinin-1 Receptor Antagonists Phase 2
19 Cortisol succinate Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Dermatologic Agents Phase 2
22 Angiogenesis Inhibitors Phase 2
23 Angiogenesis Modulating Agents Phase 2
24 Hydrocortisone 17-butyrate 21-propionate Phase 2
25 Hydrocortisone acetate Phase 2
26 Hydrocortisone-17-butyrate Phase 2
27 Anti-Bacterial Agents Phase 2
28 Anti-Infective Agents Phase 2
29 Immunosuppressive Agents Phase 2
30 Anti-Inflammatory Agents Phase 2
31 Anti-Inflammatory Agents, Non-Steroidal Phase 2
32 Antirheumatic Agents Phase 2
33 Calcineurin Inhibitors Phase 2
34
Citalopram Approved 59729-33-8 2771
35
Dapsone Approved, Investigational 80-08-0 2955
36
leucovorin Approved, Nutraceutical 58-05-9 143 6006
37
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
38
Serotonin 50-67-9 5202
39 Serotonin Agents
40 Serotonin Uptake Inhibitors
41 Muscarinic Antagonists
42 Cholinergic Agents
43 Cholinergic Antagonists
44 Neurotransmitter Uptake Inhibitors
45 Parasympatholytics
46 Antidepressive Agents
47 Antidepressive Agents, Second-Generation
48 Psychotropic Drugs
49 Autonomic Agents
50 Antiparkinson Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis Completed NCT02174419 Phase 2, Phase 3 nalbuphine HCl ER tablets 90 mg BID;nalbuphine HCl ER tablets 180 mg BID;Placebo tablets BID
2 Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis Active, not recruiting NCT02174432 Phase 2, Phase 3 nalbuphine HCl ER 90 mg BID;nalbuphine HCl ER 120 mg BID;nalbuphine HCl ER 180 mg BID
3 A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant Prurigo Nodularis (PN) Completed NCT02196324 Phase 2 serlopitant;Placebo
4 Safety and Efficacy of CC-10004 for Prurigo Nodularis Completed NCT00869089 Phase 2 CC-10004
5 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
6 Safety and Efficacy of Nemolizumab in PN Not yet recruiting NCT03181503 Phase 2 CD14152 Dose A;CD14152 placebo
7 Effectiveness of the Selective Serotonin Reuptake Inhibitor,Citalopram (Cipralex), in Prurigo Nodularis Unknown status NCT00532519 citalopram (cipralex)
8 Dapsone Prurigo Study Not yet recruiting NCT01870050 Dapsone gel - verum

Search NIH Clinical Center for Prurigo Nodularis

Genetic Tests for Prurigo Nodularis

Anatomical Context for Prurigo Nodularis

MalaCards organs/tissues related to Prurigo Nodularis:

38
Skin, Kidney, Tonsil, Endothelial, Neutrophil, Testes, Thyroid

Publications for Prurigo Nodularis

Articles related to Prurigo Nodularis:

(show top 50) (show all 181)
# Title Authors Year
1
Rapid improvement of prurigo nodularis with cyclosporine treatment. ( 29438756 )
2018
2
Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review. ( 29058335 )
2018
3
There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations. ( 28370394 )
2017
4
Prurigo Nodularis ( 29083653 )
2017
5
Acquired elastotic hemangioma-like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus/prurigo nodularis-like lesions of the knee and elbow. ( 28374436 )
2017
6
Use of Isoquercetin in the Treatment of Prurigo Nodularis. ( 29141065 )
2017
7
Hypertrophic lichen planus versus prurigo nodularis: a dermoscopic perspective. ( 27222766 )
2016
8
Aspirin and loxoprofen relieve refractory pruritus in patients with prurigo nodularis. ( 26970197 )
2016
9
Treatment of prurigo nodularis with lenalidomide. ( 27891738 )
2016
10
A Review of the Efficacy of Thalidomide and Lenalidomide in the Treatment of Refractory Prurigo Nodularis. ( 27289372 )
2016
11
Phototherapy for the treatment of prurigo nodularis: a review. ( 27617458 )
2016
12
Treatment of prurigo nodularis with dexamethasone-cyclophosphamide pulse therapy. ( 26924412 )
2016
13
Bullous pemphigoid developed in a patient with prurigo nodularis. ( 27511319 )
2016
14
Prurigo Nodularis Management. ( 27578077 )
2016
15
Treatment of prurigo nodularis with dexamethasone-cyclophosphamide pulse therapy. ( 26858054 )
2016
16
Systemic methotrexate for prurigo nodularis and keratoacanthomas in actinically damaged skin. ( 27486591 )
2016
17
Anxiety, depression and suicide in patients with prurigo nodularis. ( 27505149 )
2016
18
Acquired Reactive Perforating Dermatosis is a Variant of Prurigo Nodularis. ( 27349279 )
2016
19
Dermoscopy of prurigo nodularis. ( 25808786 )
2015
20
Intraepidermal Nerve Fibre Density is Decreased in Lesional and Inter-lesional Prurigo Nodularis and Reconstitutes on Healing of Lesions. ( 26338533 )
2015
21
Successful use of a modified Goeckerman regimen in the treatment of generalized prurigo nodularis. ( 25497953 )
2015
22
Prurigo nodularis: Picking the right treatment. ( 25973448 )
2015
23
Serotonin and interleukin-6: Association with pruritus severity, sleep quality and depression severity in Prurigo Nodularis. ( 26277226 )
2015
24
The pathogenesis of Prurigo nodularis - 'Super-Itch' in exploration. ( 26416433 )
2015
25
Prurigo nodularis after acupuncture. ( 27051775 )
2015
26
Oral Tacrolimus Treatment of Pruritus in Prurigo Nodularis. ( 25804254 )
2015
27
Biopsychosocial Factors Associated with Prurigo Nodularis in Endogenous Eczema. ( 26538749 )
2015
28
Prurigo nodularis: retrospective study of 13 cases managed with methotrexate. ( 24825138 )
2014
29
Persistent prurigo nodularis in HIV-infected patient responsive to antiretroviral therapy with raltegravir. ( 24479440 )
2014
30
Prurigo nodularis as index symptom of (non-Hodgkin) lymphoma: ultrasound as a helpful diagnostic tool in dermatological disorders of unknown origin. ( 24697249 )
2014
31
Paraphenylenediamine dye allergic contact dermatitis of mustache region manifesting as prurigo nodularis-like lesions. ( 24603506 )
2014
32
Extensive prurigo nodularis: characterization and etiology. ( 24662043 )
2014
33
Intractable prurigo nodularis successfully treated with combination therapy with a newly developed excimer laser and topical steroids. ( 24945654 )
2014
34
Prurigo nodularis and Hashimoto thyroiditis. ( 25446192 )
2014
35
Prurigo nodularis in a peritoneal dialysis patient. ( 24380918 )
2014
36
Oral ketotifen and topical antibiotic therapy in the management of pruritus in prurigo nodularis: a randomized, controlled, single-blind, parallel study. ( 24082179 )
2013
37
Use of lenalidomide in treating refractory prurigo nodularis. ( 23545923 )
2013
38
Combination therapy of fexofenadine and montelukast is effective in prurigo nodularis and pemphigoid nodularis. ( 24102897 )
2013
39
Prurigo nodularis and dialyzer membrane. ( 23676832 )
2013
40
Treatment of prurigo nodularis with pregabalin. ( 23013514 )
2013
41
Linear IgA bullous dermatosis with a prurigo nodularis-like appearance. ( 23306219 )
2013
42
Evaluation of the Antipruritic Effects of Topical Pimecrolimus in Non-Atopic Prurigo Nodularis: Results of a Randomized, Hydrocortisone-Controlled, Double-Blind Phase II Trial. ( 24281309 )
2013
43
Successful treatment of chronic intractable itching using oral pregabalin in a patient with diabetes and systemic prurigo nodularis: a case report of an iliopsoas muscle abscess. ( 24292753 )
2013
44
Prurigo nodularis: an update on etiopathogenesis and therapy. ( 23767411 )
2013
45
Prurigo nodularis-like skin eruptions in a patient with IgG4-related disease. ( 24001614 )
2013
46
Aberrant epidermal expression of semaphorin 3A and nerve growth factor in prurigo nodularis. ( 23398122 )
2013
47
Prurigo nodularis in hepatitis C infection: result of an occupational disease? ( 22002555 )
2012
48
Accidental PUVA burns, vitiligo and atopic diathesis resulting in prurigo nodularis: a logical but undocumented rarity. ( 23197209 )
2012
49
Treatment of refractory prurigo nodularis with lenalidomide. ( 22801610 )
2012
50
Atopic prurigo nodularis responds to intravenous immunoglobulins. ( 21910702 )
2012

Variations for Prurigo Nodularis

Expression for Prurigo Nodularis

Search GEO for disease gene expression data for Prurigo Nodularis.

Pathways for Prurigo Nodularis

GO Terms for Prurigo Nodularis

Cellular components related to Prurigo Nodularis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 NGF NGFR RNASE3 SEMA3A TAC1

Biological processes related to Prurigo Nodularis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.37 NGF NGFR
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.32 NGF NGFR
3 negative regulation of neuron projection development GO:0010977 9.26 NGFR SEMA3A
4 positive regulation of axonogenesis GO:0050772 9.16 NGF NGFR
5 neurotrophin TRK receptor signaling pathway GO:0048011 8.96 NGF NGFR
6 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 8.62 NGF NGFR

Sources for Prurigo Nodularis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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