MCID: PRR013
MIFTS: 34

Prurigo Nodularis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Prurigo Nodularis

MalaCards integrated aliases for Prurigo Nodularis:

Name: Prurigo Nodularis 50 52 69

Classifications:



External Ids:

ICD10 33 L28.1

Summaries for Prurigo Nodularis

NIH Rare Diseases : 50 prurigo nodularis is a skin condition characterized by hard crusty lumps that itch intensely.  the exact cause of the condition is unknown. however, it can occur in isolation or as a result of repeated trauma to chronic pruritus (itching). treatment for the condition can be challenging. last updated: 12/30/2015

MalaCards based summary : Prurigo Nodularis is related to marasmus and cecum adenoma. An important gene associated with Prurigo Nodularis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Phospholipase-C Pathway and p70S6K Signaling. The drugs Nalbuphine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, tonsil and neutrophil.

Wikipedia : 72 Prurigo nodularis (PN) is a skin disease characterised by pruritic (itchy) nodules which usually appear... more...

Related Diseases for Prurigo Nodularis

Diseases related to Prurigo Nodularis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Related Disease Score Top Affiliating Genes
1 marasmus 10.3 NGF RNASE3
2 cecum adenoma 10.2 NGF RNASE3
3 epidermolysis bullosa simplex superficialis 10.2 NGF RNASE3
4 dermatitis 10.2
5 respiratory failure 10.2 NGF NGFR
6 lymphoma 10.1
7 fuchs' heterochromic uveitis 10.1 NGF RNASE3
8 hepatitis 10.1
9 tonsillitis 10.1
10 bullous pemphigoid 10.1
11 neuropathy 10.1
12 hodgkin lymphoma 10.0
13 keratoacanthoma 10.0
14 neurodermatitis 10.0
15 uremia 10.0
16 herpes zoster 10.0
17 lichen planus 10.0
18 somatoform disorder 9.9 RNASE3 TAC1
19 diffuse large b-cell lymphoma 9.9 NGF NGFR
20 malignant renovascular hypertension 9.9 NGF TAC1
21 eyelid neoplasm 9.9 RNASE3 TAC1
22 pseudohypoaldosteronism, type iid 9.9 NGF RNASE3
23 tinea favosa 9.9 NGF TAC1
24 hemopericardium 9.9 NGF TAC1
25 benign familial infantile epilepsy 9.9 NGF TAC1
26 dehydration polycythemia 9.8 RNASE3 TAC1
27 hashimoto thyroiditis 9.8
28 celiac disease 9.8
29 atopy 9.8
30 burns 9.8
31 hemangioma 9.8
32 colitis 9.8
33 collagenous colitis 9.8
34 filariasis 9.8
35 squamous cell carcinoma 9.8
36 hepatitis c 9.8
37 neuroma 9.8
38 granular cell tumor 9.8
39 transitional cell carcinoma 9.8
40 contact dermatitis 9.8
41 allergic contact dermatitis 9.8
42 porokeratosis 9.8
43 tuberculosis 9.8
44 thyroiditis 9.8
45 peritonitis 9.8
46 scabies 9.8
47 dermatitis herpetiformis 9.8
48 vasculitis 9.8
49 psoriasis 9.8
50 amyloidosis 9.8

Graphical network of the top 20 diseases related to Prurigo Nodularis:



Diseases related to Prurigo Nodularis

Symptoms & Phenotypes for Prurigo Nodularis

Drugs & Therapeutics for Prurigo Nodularis

Drugs for Prurigo Nodularis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nalbuphine Approved Phase 2, Phase 3 20594-83-6 5360630 5311304
2 Peripheral Nervous System Agents Phase 2, Phase 3
3 Analgesics Phase 2, Phase 3
4 Analgesics, Opioid Phase 2, Phase 3
5 Antipruritics Phase 2, Phase 3
6 Central Nervous System Depressants Phase 2, Phase 3
7 Narcotic Antagonists Phase 2, Phase 3
8 Narcotics Phase 2, Phase 3
9
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
10
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
11
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
12
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
13 Serlopitant Investigational Phase 2 860642-69-9
14
Substance P Investigational Phase 2 33507-63-0 44359816
15
Butyric Acid Experimental Phase 2 107-92-6 264
16 Neurotransmitter Agents Phase 2
17 neurokinin A Phase 2
18 Neurokinin-1 Receptor Antagonists Phase 2
19 Analgesics, Non-Narcotic Phase 2
20 Angiogenesis Inhibitors Phase 2
21 Angiogenesis Modulating Agents Phase 2
22 Anti-Bacterial Agents Phase 2
23 Anti-Infective Agents Phase 2
24 Anti-Inflammatory Agents Phase 2
25 Anti-Inflammatory Agents, Non-Steroidal Phase 2
26 Antirheumatic Agents Phase 2
27 Immunosuppressive Agents Phase 2
28 Calcineurin Inhibitors Phase 2
29 Cortisol succinate Phase 2
30 Dermatologic Agents Phase 2
31 Hydrocortisone 17-butyrate 21-propionate Phase 2
32 Hydrocortisone acetate Phase 2
33 Hydrocortisone-17-butyrate Phase 2
34
Citalopram Approved 59729-33-8 2771
35
Dapsone Approved, Investigational 80-08-0 2955
36
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
37
leucovorin Approved, Nutraceutical 58-05-9 143 6006
38 Antidepressive Agents
39 Antidepressive Agents, Second-Generation
40 Antiparkinson Agents
41 Autonomic Agents
42 Cholinergic Agents
43 Cholinergic Antagonists
44 Muscarinic Antagonists
45 Neurotransmitter Uptake Inhibitors
46 Parasympatholytics
47 Psychotropic Drugs
48
Serotonin 50-67-9 5202
49 Serotonin Agents
50 Serotonin Uptake Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis Completed NCT02174419 Phase 2, Phase 3 nalbuphine HCl ER tablets 90 mg BID;nalbuphine HCl ER tablets 180 mg BID;Placebo tablets BID
2 Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis Active, not recruiting NCT02174432 Phase 2, Phase 3 nalbuphine HCl ER 90 mg BID;nalbuphine HCl ER 120 mg BID;nalbuphine HCl ER 180 mg BID
3 A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant Prurigo Nodularis (PN) Completed NCT02196324 Phase 2 serlopitant;Placebo
4 Safety and Efficacy of CC-10004 for Prurigo Nodularis Completed NCT00869089 Phase 2 CC-10004
5 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
6 Safety and Efficacy of Nemolizumab in PN Not yet recruiting NCT03181503 Phase 2 CD14152 Dose A;CD14152 placebo
7 Effectiveness of the Selective Serotonin Reuptake Inhibitor,Citalopram (Cipralex), in Prurigo Nodularis Unknown status NCT00532519 citalopram (cipralex)
8 Dapsone Prurigo Study Not yet recruiting NCT01870050 Dapsone gel - verum

Search NIH Clinical Center for Prurigo Nodularis

Genetic Tests for Prurigo Nodularis

Anatomical Context for Prurigo Nodularis

MalaCards organs/tissues related to Prurigo Nodularis:

39
Skin, Tonsil, Neutrophil, Endothelial, T Cells, Thyroid, Testes

Publications for Prurigo Nodularis

Articles related to Prurigo Nodularis:

(show top 50) (show all 177)
id Title Authors Year
1
Acquired elastotic hemangioma-like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus/prurigo nodularis-like lesions of the knee and elbow. ( 28374436 )
2017
2
There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations. ( 28370394 )
2017
3
Anxiety, depression and suicide in patients with prurigo nodularis. ( 27505149 )
2016
4
Prurigo Nodularis Management. ( 27578077 )
2016
5
A Review of the Efficacy of Thalidomide and Lenalidomide in the Treatment of Refractory Prurigo Nodularis. ( 27289372 )
2016
6
Treatment of prurigo nodularis with dexamethasone-cyclophosphamide pulse therapy. ( 26924412 )
2016
7
Treatment of prurigo nodularis with lenalidomide. ( 27891738 )
2016
8
Systemic methotrexate for prurigo nodularis and keratoacanthomas in actinically damaged skin. ( 27486591 )
2016
9
Acquired Reactive Perforating Dermatosis is a Variant of Prurigo Nodularis. ( 27349279 )
2016
10
Aspirin and loxoprofen relieve refractory pruritus in patients with prurigo nodularis. ( 26970197 )
2016
11
Bullous pemphigoid developed in a patient with prurigo nodularis. ( 27511319 )
2016
12
Treatment of prurigo nodularis with dexamethasone-cyclophosphamide pulse therapy. ( 26858054 )
2016
13
Phototherapy for the treatment of prurigo nodularis: a review. ( 27617458 )
2016
14
Hypertrophic lichen planus versus prurigo nodularis: a dermoscopic perspective. ( 27222766 )
2016
15
Prurigo nodularis after acupuncture. ( 27051775 )
2015
16
The pathogenesis of Prurigo nodularis - 'Super-Itch' in exploration. ( 26416433 )
2015
17
Prurigo nodularis: Picking the right treatment. ( 25973448 )
2015
18
Dermoscopy of prurigo nodularis. ( 25808786 )
2015
19
Serotonin and interleukin-6: Association with pruritus severity, sleep quality and depression severity in Prurigo Nodularis. ( 26277226 )
2015
20
Oral Tacrolimus Treatment of Pruritus in Prurigo Nodularis. ( 25804254 )
2015
21
Successful use of a modified Goeckerman regimen in the treatment of generalized prurigo nodularis. ( 25497953 )
2015
22
Intraepidermal Nerve Fibre Density is Decreased in Lesional and Inter-lesional Prurigo Nodularis and Reconstitutes on Healing of Lesions. ( 26338533 )
2015
23
Biopsychosocial Factors Associated with Prurigo Nodularis in Endogenous Eczema. ( 26538749 )
2015
24
Prurigo nodularis in a peritoneal dialysis patient. ( 24380918 )
2014
25
Extensive prurigo nodularis: characterization and etiology. ( 24662043 )
2014
26
Prurigo nodularis: retrospective study of 13 cases managed with methotrexate. ( 24825138 )
2014
27
Prurigo nodularis as index symptom of (non-Hodgkin) lymphoma: ultrasound as a helpful diagnostic tool in dermatological disorders of unknown origin. ( 24697249 )
2014
28
Prurigo nodularis and Hashimoto thyroiditis. ( 25446192 )
2014
29
Persistent prurigo nodularis in HIV-infected patient responsive to antiretroviral therapy with raltegravir. ( 24479440 )
2014
30
Intractable prurigo nodularis successfully treated with combination therapy with a newly developed excimer laser and topical steroids. ( 24945654 )
2014
31
Paraphenylenediamine dye allergic contact dermatitis of mustache region manifesting as prurigo nodularis-like lesions. ( 24603506 )
2014
32
Prurigo nodularis-like skin eruptions in a patient with IgG4-related disease. ( 24001614 )
2013
33
Prurigo nodularis: an update on etiopathogenesis and therapy. ( 23767411 )
2013
34
Linear IgA bullous dermatosis with a prurigo nodularis-like appearance. ( 23306219 )
2013
35
Aberrant epidermal expression of semaphorin 3A and nerve growth factor in prurigo nodularis. ( 23398122 )
2013
36
Prurigo nodularis and dialyzer membrane. ( 23676832 )
2013
37
Evaluation of the Antipruritic Effects of Topical Pimecrolimus in Non-Atopic Prurigo Nodularis: Results of a Randomized, Hydrocortisone-Controlled, Double-Blind Phase II Trial. ( 24281309 )
2013
38
Treatment of prurigo nodularis with pregabalin. ( 23013514 )
2013
39
Use of lenalidomide in treating refractory prurigo nodularis. ( 23545923 )
2013
40
Combination therapy of fexofenadine and montelukast is effective in prurigo nodularis and pemphigoid nodularis. ( 24102897 )
2013
41
Successful treatment of chronic intractable itching using oral pregabalin in a patient with diabetes and systemic prurigo nodularis: a case report of an iliopsoas muscle abscess. ( 24292753 )
2013
42
Oral ketotifen and topical antibiotic therapy in the management of pruritus in prurigo nodularis: a randomized, controlled, single-blind, parallel study. ( 24082179 )
2013
43
Treatment of refractory prurigo nodularis with lenalidomide. ( 22801610 )
2012
44
Prurigo nodularis in hepatitis C infection: result of an occupational disease? ( 22002555 )
2012
45
Accidental PUVA burns, vitiligo and atopic diathesis resulting in prurigo nodularis: a logical but undocumented rarity. ( 23197209 )
2012
46
Atopic prurigo nodularis responds to intravenous immunoglobulins. ( 21910702 )
2012
47
Prurigo nodularis as the first manifestation of a chronic autoimmune cholestatic hepatitis. ( 22098015 )
2011
48
Hypnosis and acupuncture (hypnopuncture) for prurigo nodularis: a case report. ( 21598842 )
2011
49
Thalidomide in 42 patients with prurigo nodularis Hyde. ( 21952556 )
2011
50
Predictive values of prurigo nodularis and herpes zoster for HIV infection and immunosuppression requiring HAART in French Guiana. ( 21621233 )
2011

Variations for Prurigo Nodularis

Expression for Prurigo Nodularis

Search GEO for disease gene expression data for Prurigo Nodularis.

Pathways for Prurigo Nodularis

GO Terms for Prurigo Nodularis

Cellular components related to Prurigo Nodularis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 NGF NGFR RNASE3 SEMA3A TAC1

Biological processes related to Prurigo Nodularis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.37 NGF NGFR
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.32 NGF NGFR
3 negative regulation of neuron projection development GO:0010977 9.26 NGFR SEMA3A
4 positive regulation of axonogenesis GO:0050772 9.16 NGF NGFR
5 neurotrophin TRK receptor signaling pathway GO:0048011 8.96 NGF NGFR
6 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 8.62 NGF NGFR

Sources for Prurigo Nodularis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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