PASH
MCID: PSD079
MIFTS: 25

Pseudoangiomatous Stromal Hyperplasia (PASH) malady

Summaries for Pseudoangiomatous Stromal Hyperplasia

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43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Pseudoangiomatous stromal hyperplasia (pash) is a type of non-cancerous breast lesion. it typically affects women in the reproductive age group. the size of the lesion varies, but small microscopic pash is much more common than larger masses. microscopic pash is often an incidental finding in breast biopsies done for other non-cancerous or cancerous lesions. tumorous pash presents as a firm, painless breast mass or a dense region on a mammogram.  last updated: 4/8/2011

MalaCards: Pseudoangiomatous Stromal Hyperplasia, also known as pseudoangiomatous stromal hyperplasia of the breast, is related to neurofibromatosis and gynecomastia. An important gene associated with Pseudoangiomatous Stromal Hyperplasia is ACTC1 (actin, alpha, cardiac muscle 1). The compounds progesterone and imatinib have been mentioned in the context of this disorder. Affiliated tissues include lymph node and breast.

Wikipedia:64 In breast pathology, pseudoangiomatous stromal hyperplasia, commonly abbreviated PASH, is an overgrowth... more...

Aliases & Classifications for Pseudoangiomatous Stromal Hyperplasia

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43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

pseudoangiomatous stromal hyperplasia 43 61
pseudoangiomatous stromal hyperplasia of the breast 43
mammary pseudoangiomatous stromal hyperplasia 43
pash 43


Related Diseases for Pseudoangiomatous Stromal Hyperplasia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pseudoangiomatous Stromal Hyperplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 20)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis10.7
2gynecomastia10.5
3phyllode tumor10.5
4pyoderma gangrenosum - acne - suppurative hidradenitis10.2
5pyoderma gangrenosum10.0
6acne10.0
7smooth muscle tumor10.0ACTC1
8teratoma10.0ACTC1
9leiomyosarcoma10.0ACTC1
10gastrointestinal stromal tumor10.0ACTC1
11papilloma10.0ACTC1
12fibrosarcoma10.0ACTC1
13wilms tumor10.0ACTC1
14leiomyoma10.0ACTC1
15rhabdomyosarcoma10.0ACTC1
16medulloblastoma10.0ACTC1
17endometriosis10.0ACTC1
18basal cell carcinoma10.0BCL2, ACTC1
19burkitt's lymphoma10.0ACTC1, BCL2
20breast cancer10.0BCL2, ACTC1

Graphical network of diseases related to Pseudoangiomatous Stromal Hyperplasia:



Diseases related to pseudoangiomatous stromal hyperplasia

Clinical Features for Pseudoangiomatous Stromal Hyperplasia

Drugs & Therapeutics for Pseudoangiomatous Stromal Hyperplasia

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pseudoangiomatous Stromal Hyperplasia

Anatomical Context for Pseudoangiomatous Stromal Hyperplasia

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33MalaCards
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MalaCards organs/tissues related to Pseudoangiomatous Stromal Hyperplasia:

33
Lymph node, Breast

Animal Models for Pseudoangiomatous Stromal Hyperplasia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pseudoangiomatous Stromal Hyperplasia

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51PubMed
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Articles related to Pseudoangiomatous Stromal Hyperplasia:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
A case of tumor-forming pseudoangiomatous stromal hyperplasia of the breast. (20072822)
2013
2
Phyllodes Tumor of Anogenital Mammary-like Glands with Diffuse Pseudoangiomatous Stromal Hyperplasia. (24272935)
2013
3
Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. (22583194)
2012
4
A case of a giant pseudoangiomatous stromal hyperplasia of the breast: magnetic resonance imaging findings. (22826780)
2012
5
Pseudoangiomatous stromal hyperplasia (PASH) causing massive breast enlargement: MRI findings. (23110315)
2012
6
Breast pseudoangiomatous stromal hyperplasia during early childhood. (22181578)
2011
7
Pseudoangiomatous stromal hyperplasia of the breast: an unusual pathology necessitating bilateral mastectomy during pregnancy. (21418488)
2011
8
Pseudoangiomatous stromal hyperplasia (PASH) tumour at the surgical scar site in a patient of carcinoma breast. (22688488)
2011
9
Pseudoangiomatous stromal hyperplasia with giant cells in the female breast. No association with neurofibromatosis? (21598761)
2011
10
Pseudoangiomatous stromal hyperplasia of breast in man: a case report. (21545435)
2011
11
Giant tumoural pseudoangiomatous stromal hyperplasia of the breast in the adolescence. (22295353)
2011
12
Pseudoangiomatous stromal hyperplasia (PASH): a brief review. (20887819)
2011
13
Pseudoangiomatous stromal hyperplasia of the breast in a 10-year-old girl. (21843705)
2011
14
Massive nodular pseudoangiomatous stromal hyperplasia (PASH) of the breast arising simultaneously in the axilla and vulva. (21285079)
2011
15
Tumoral pseudoangiomatous stromal hyperplasia of the breast: a rare entity. (20699535)
2010
16
Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells. (20035149)
2010
17
Pseudoangiomatous stromal hyperplasia: a study of the mammographic and sonographic features. (20103437)
2010
18
Pseudoangiomatous stromal hyperplasia: imaging findings with pathologic and clinical correlation. (20858836)
2010
19
Pseudoangiomatous stromal hyperplasia of the breast: a contemporary approach to its clinical and radiologic features and ideal management. (20708765)
2010
20
Pseudoangiomatous stromal hyperplasia (PASH) of the breast with foci of morphologic malignancy: a case of PASH with malignant transformation? (18611932)
2010
21
Pseudoangiomatous stromal hyperplasia of the breast. (19653734)
2009
22
Pseudoangiomatous stromal hyperplasia of the breast in pediatric patients: an underrecognized entity. (19606909)
2009
23
Giant nodular pseudoangiomatous stromal hyperplasia (PASH) of the breast presenting as a rapidly growing tumour. (19694241)
2009
24
Pseudoangiomatous stromal hyperplasia in a complex neoplastic lesion involving anogenital mammary-like glands. (19508499)
2009
25
Pseudoangiomatous stromal hyperplasia (PASH) of the breast: intraductal appearance. (19751351)
2009
26
The contrasting presentation and management of pseudoangiomatous stromal hyperplasia of the breast. (18362994)
2008
27
Pseudoangiomatous stromal hyperplasia of breast: a case report. (18795085)
2008
28
Pseudoangiomatous stromal hyperplasia. A case for bilateral mastectomy in a 12-year-old girl. (17983404)
2007
29
Fast-growing pseudoangiomatous stromal hyperplasia of the breast: report of a case. (17952527)
2007
30
Rapidly enlarging tumoral pseudoangiomatous stromal hyperplasia in a 15-year-old patient: distinguishing sonographic and magnetic resonance imaging findings and correlation with histologic findings. (17646374)
2007
31
Mammary pseudoangiomatous stromal hyperplasia composed of predominantly giant cells: an unusual variant. (17983397)
2007
32
A case of nodular pseudoangiomatous stromal hyperplasia (PASH). (17146161)
2006
33
Mammary pseudoangiomatous stromal hyperplasia presenting as an axillary mass. (15695083)
2005
34
Aspiration biopsy of nodular pseudoangiomatous stromal hyperplasia of the breast: clinicopathologic correlates in 10 cases. (15880710)
2005
35
Pseudoangiomatous stromal hyperplasia in lesions involving anogenital mammary-like glands. (16096415)
2005
36
Nodular pseudoangiomatous stromal hyperplasia of mammary stroma in a case showing rapid tumor growth. (16286916)
2005
37
Pseudoangiomatous stromal hyperplasia of the breast in two adolescent females. (15279183)
2004
38
Fine-needle aspiration cytology of pseudoangiomatous stromal hyperplasia of the breast. (15108236)
2004
39
Mammary pseudoangiomatous stromal hyperplasia. A reappraisal of the fine needle aspiration cytology findings. (12789917)
2003
40
Pseudoangiomatous stromal hyperplasia of the breast. (11943906)
2002
41
Nodular myofibroblastic stromal hyperplasia of the mammary gland as an accurate name for pseudoangiomatous stromal hyperplasia of the mammary gland. (12199757)
2002
42
Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread. (12207782)
2002
43
Gynecomastia with pseudoangiomatous stromal hyperplasia and multinucleated giant cells. Association with neurofibromatosis type 1. (12111205)
2002
44
Pseudoangiomatous stromal hyperplasia: presentation as a mass in the female nipple. (11678805)
2001
45
Fine needle aspiration cytology of mammary pseudoangiomatous stromal hyperplasia. A case report. (10578994)
1999
46
Breast imaging case of the day. Pseudoangiomatous stromal hyperplasia. (10464812)
1999
47
Fine-needle aspiration of pseudoangiomatous stromal hyperplasia of the breast. (10319238)
1999
48
Nodular pseudoangiomatous stromal hyperplasia of the breast. Cytologic features. (9568132)
1998
49
Pseudoangiomatous stromal hyperplasia: mammographic, sonographic, and clinical patterns. (8539361)
1996
50
Immunocytochemical analysis of estrogen and progesterone receptors in benign stromal lesions of the breast. Evidence for hormonal etiology in pseudoangiomatous hyperplasia of mammary stroma. (1989462)
1991

Genetic Variations for Pseudoangiomatous Stromal Hyperplasia

Expression for genes affiliated with Pseudoangiomatous Stromal Hyperplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pseudoangiomatous Stromal Hyperplasia

Search GEO for disease gene expression data for Pseudoangiomatous Stromal Hyperplasia.

Pathways for genes affiliated with Pseudoangiomatous Stromal Hyperplasia

Compounds for genes affiliated with Pseudoangiomatous Stromal Hyperplasia

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Pseudoangiomatous Stromal Hyperplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1progesterone45 60 29 11 2413.1BCL2, ACTC1
2imatinib45 50 1111.0BCL2, ACTC1
3paraffin458.8BCL2, ACTC1

GO Terms for genes affiliated with Pseudoangiomatous Stromal Hyperplasia

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16Gene Ontology
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Biological processes related to Pseudoangiomatous Stromal Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:0069159.1BCL2, ACTC1
2response to drugGO:0424938.8BCL2, ACTC1

Products for genes affiliated with Pseudoangiomatous Stromal Hyperplasia

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Sources for Pseudoangiomatous Stromal Hyperplasia

3CDC
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14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet