Pseudobulbar Palsy disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Pseudobulbar Palsy

Sources:
⁶³Wikipedia, ³²MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard

Wikipedia:⁶³ Pseudobulbar palsy is a medical condition characterised by the inability to control facial movements... more...

MalaCards: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to macrogyria, pseudobulbar palsy and mental retardation and lateral sclerosis. An important gene associated with Pseudobulbar Palsy is EMX2 (empty spiracles homeobox 2), and among its related pathways are Dorso-ventral axis formation and NOTCH2 intracellular domain regulates transcription. Affiliated tissues include tongue, brain and cerebellum, and related mouse phenotype nervous system.

Aliases & Classifications for Pseudobulbar Palsy

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁶⁰UMLS, ²⁷ICD9CM, ⁵⁶SNOMED-CT, ³⁴MeSH
See all sources

Aliases & Descriptions:

pseudobulbar palsy ⁸ ¹⁰ ⁶⁰

pseudobulbar paralysis ⁸

External Ids:

Disease Ontology⁸ DOID:12680

ICD9CM²⁷ 335.23

SNOMED-CT⁵⁶ 7379000

MeSH³⁴ D020828

UMLS⁶⁰ C0033790

Related Diseases for Pseudobulbar Palsy

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 27)

id	Related Disease	Score	Top Affiliating Genes
1	macrogyria, pseudobulbar palsy and mental retardation	10.5
2	lateral sclerosis	10.3
3	amyotrophic lateral sclerosis	10.3
4	dementia	10.3
5	cerebritis	10.1
6	cerebral malaria	10.1
7	malaria	10.1
8	antiphospholipid syndrome	10.1
9	petroclival meningioma	10.1
10	neuronitis	10.1
11	progressive supranuclear palsy	10.1
12	progressive multifocal leukoencephalopathy	10.1
13	encephalitis	10.1
14	endocarditis	10.1
15	leukemia	10.1
16	meningioma	10.1
17	ophthalmoplegia	10.1
18	speech disorder	10.1
19	trypanosomiasis	10.1
20	bilateral frontoparietal polymicrogyria	10.1
21	lissencephaly	10.0	GPR56, EMX2
22	polymicrogyria	10.0	GPR56
23	focal epilepsy	10.0	GPR56, EMX2
24	stroke, ischemic	10.0	NOTCH3, NOTCH4
25	cadasil	10.0	NOTCH4, NOTCH3
26	microcephaly	10.0	RAB3GAP1, ARFGEF2
27	periventricular nodular heterotopia	10.0	ARFGEF2, EMX2, GPR56

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:

Clinical Features for Pseudobulbar Palsy

Drugs & Therapeutics for Pseudobulbar Palsy

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Pseudobulbar Palsy

Drug clinical trials:

Search ClinicalTrials for Pseudobulbar Palsy

Search NIH Clinical Center for Pseudobulbar Palsy

Search CenterWatch for Pseudobulbar Palsy

Genetic Tests for Pseudobulbar Palsy

Anatomical Context for Pseudobulbar Palsy

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Pseudobulbar Palsy:

³²

Tongue, Brain, Cerebellum, Trachea

Animal Models for Pseudobulbar Palsy or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Pseudobulbar Palsy:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	7.1	SPG20, NOTCH4, NOTCH3, RAB3GAP1, GPR56, EMX2

Publications for Pseudobulbar Palsy

Sources:
⁵⁰PubMed
See all sources

Articles related to Pseudobulbar Palsy:

(show all 38)

id	Title	Authors	Year
1	Pure pseudobulbar palsy due to a capsular infarction. (22504270)	Maeda K.... Shiraishi T.	2012
2	Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)	Frost L.	2011
3	Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. (18305298)	Graham K.C.... Spiegel D.R.	2008
4	Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. (17078444)	Hong C.	2006
5	Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. (16771181)	Kim H.I.... Kim S.U.	2006
6	Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. (16314998)	Kinirons P.... Murphy R.P.	2005
7	Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. (15172029)	Arboix A.... Sans-Sabrafen J.	2004
8	Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. (17167648)	McCormick W.E.... Lee J.H.	2002
9	Left atrial myxoma presenting as pseudobulbar palsy. (12134197)	Kumar A.... Malhotra H.S.	2002
10	Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. (11848316)	Aleem M.A.... Jayapal V.	2001
11	Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. (10965170)	Frank H.G.... Landis T.	2000
12	Pseudobulbar palsy recovery following HSV encephalitis in AIDS. (10726949)	Kulasegaram R.... Rodgers C.A.	2000
13	Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. (10453580)	Shi X.... Zhang H.	1999
14	Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. (9926359)	Leroy-Malherbe V.... Arabia C.	1998
15	Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. (9153602)	Abrahams S.... Leigh P.N.	1997
16	Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. (7750810)	Karacostas D.... Bogousslavsky J.	1994
17	Pseudobulbar palsy associated with trismus. (7824418)	Lai M.M.... Howard R.S.	1994
18	Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. (2011096)	Shaw P.J.... Stevens M.M.	1991
19	Pseudobulbar palsy: a clinical computed tomography study. (2298226)	Loeb C.... Del Sette M.	1990
20	Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. (2715610)	Grattan-Smith P.J.... Boldt D.W.	1989
21	Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (2738597)	Asfora W.T.... Kjellberg R.N.	1989
22	Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)	Kuzniecky R.... Leppik I.	1989
23	Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. (3366147)	Mancardi G.L.... Loeb C.	1988
24	Neoplastic obstruction of the trachea complicating pseudobulbar palsy. (3406789)	Aumentado D.J.... Payne C.B.	1988
25	Trismus in pseudobulbar palsy. (4093375)	Dhamija R.M.... Maheshwari M.C.	1985
26	Pseudobulbar palsy after carotid endarterectomy. (4047367)	Solomon R.A.... Correll J.W.	1985
27	Pseudobulbar palsy after posterior fossa operation in children. (6504288)	Wisoff J.H.... Epstein F.J.	1984
28	Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. (7129273)	Hirose H.... Sawashima M.	1982
29	Lithium carbonate in pseudobulbar palsy. (6782937)	Massey E.W.... Lowe S.	1981
30	Dysphagia of pseudobulbar palsy successfully treated by hypnosis. (6929999)	Black S.	1980
31	Control of emotional expression in pseudobulbar palsy. A personal experience. (911237)	Lieberman A.... Benson D.F.	1977
32	Pseudobulbar palsy. (5419589)	Flora G.C.	1970
33	Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)	SHAFAR J.	1967
34	SUPRANUCLEAR (PSEUDOBULBAR) PALSY. (14332003)	ARING C.D.	1965
35	PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)	Steele J.C.... Olszewski J.	1964
36	SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". (14272249)	Richardson J.C.... Olszewski J.	1963
37	Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. (14777908)	HEATHFIELD K.W.... JEWESBURY E.C.	1950
38	Facial seborrhoea in arteriosclerotic pseudobulbar palsy. (18933673)	ELLIOTT F.A.	1948

Genes related to Pseudobulbar Palsy

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Pseudobulbar Palsy:

id	Symbol	Description	Score	Implication
1	EMX2	empty spiracles homeobox 2	21.02	GeneCards inferred : Disorders (show sections)
2	SRPX2	sushi-repeat containing protein, X-linked 2	19.02	GeneCards inferred : Disorders (show sections)
3	SPG20	spastic paraplegia 20 (Troyer syndrome)	17.02	GeneCards inferred : Disorders (show sections)
4	NOTCH3	notch 3	15.02	GeneCards inferred : Disorders (show sections)
5	NOTCH4	notch 4	13.02	GeneCards inferred : Disorders (show sections)
6	GPR56	G protein-coupled receptor 56	11.02	GeneCards inferred : Disorders (show sections)
7	KIAA1279	KIAA1279	9.02	GeneCards inferred : Disorders (show sections)
8	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	7.02	GeneCards inferred : Disorders (show sections)
9	RAB3GAP1	RAB3 GTPase activating protein subunit 1 (catalytic)	5.02	GeneCards inferred : Disorders (show sections)
10	RAB3IL1	RAB3A interacting protein (rabin3)-like 1	3.02	GeneCards inferred : Disorders (show sections)

Products for genes related to Pseudobulbar Palsy disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	8	8	10
2	LSBio	-	-	10

Genetic Variations for Pseudobulbar Palsy

Expression for genes affiliated with Pseudobulbar Palsy

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Pseudobulbar Palsy

Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for genes affiliated with Pseudobulbar Palsy

Sources:
²⁹KEGG, ⁵³Reactome, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Dorso-ventral axis formation²⁹	9.7	NOTCH4, NOTCH3
2	NOTCH2 intracellular domain regulates transcription⁵³ Hide members Notch-HLH transcription pathway⁵³ NICD traffics to nucleus⁵³	9.7	NOTCH4, NOTCH3
3	Post-transcriptional Silencing By Small RNAs⁵³ Hide members Pre-NOTCH Transcription and Translation⁵³	9.7	NOTCH4, NOTCH3
4	Signaling by NOTCH3⁵³ Hide members Pre-NOTCH Processing in the Endoplasmic Reticulum⁵³ Signaling by NOTCH4⁵³ A third proteolytic cleavage releases NICD⁵³	9.7	NOTCH4, NOTCH3
5	Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor⁵³	9.7	NOTCH4, NOTCH3
6	Notch signaling pathway³⁷	9.7	NOTCH4, NOTCH3
7	Pre-NOTCH Processing in Golgi⁵³ Hide members Pre-NOTCH Expression and Processing⁵³	9.7	NOTCH3, NOTCH4