MCID: PSD001
MIFTS: 33

Pseudobulbar Palsy malady

Category: Neuronal diseases

Aliases & Classifications for Pseudobulbar Palsy

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Aliases & Descriptions for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy 11 39 13 68
 
Pseudobulbar Paralysis 11 27

Classifications:



External Ids:

Disease Ontology11 DOID:12680
ICD9CM32 335.23
SNOMED-CT62 7379000
MeSH39 D020828

Summaries for Pseudobulbar Palsy

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Wikipedia:71 Pseudobulbar palsy is a medical condition characterized by the inability to control facial movements... more...

MalaCards based summary: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to macrogyria, pseudobulbar palsy and mental retardation and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, and has symptoms including hemiplegia, hemiplegia and ophthalmoplegia. An important gene associated with Pseudobulbar Palsy is SRPX2 (Sushi Repeat Containing Protein, X-Linked 2), and among its related pathways are Thyroid hormone signaling pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include tongue, brain and cerebellum, and related mouse phenotypes are growth/size/body region and vision/eye.

Related Diseases for Pseudobulbar Palsy

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Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
idRelated DiseaseScoreTop Affiliating Genes
1macrogyria, pseudobulbar palsy and mental retardation12.0
2cerebral arteriopathy with subcortical infarcts and leukoencephalopathy11.0
3motor neuron disease11.0
4cadasil 211.0
5duodenal obstruction10.1NOTCH3, NOTCH4
6bartonellosis10.1NOTCH3, NOTCH4
7dementia10.0
8dystonia10.0
9phosphoglycerate dehydrogenase deficiency10.0NOTCH3, NOTCH4
10sclerosing keratitis9.9HTRA1, NOTCH3, NOTCH4
11hyperostosis9.9SIX3, SRPX2
12epilepsy9.9
13lateral sclerosis9.9
14dysphagia9.9
15fga-related congenital afibrinogenemia9.9EMX2, SIX3
16persistent vegetative state9.9ARFGEF2, EMX2
17acromesomelic dysplasia, maroteaux type9.9NOTCH3, NOTCH4
18gastrointestinal defects and immunodeficiency syndrome9.9EMX2, SIX3
19angiodysplasia9.8ARFGEF2, SIX3
20malaria9.8
21cerebritis9.8
22creutzfeldt-jakob disease9.8
23leukemia9.8
24trypanosomiasis9.8
25endocarditis9.8
26antiphospholipid syndrome9.8
27progressive multifocal leukoencephalopathy9.8
28petroclival meningioma9.8
29neuronitis9.8
30speech disorder9.8
31encephalitis9.8
32neuronal migration disorders9.8
33otopalatodigital syndrome, type ii9.5ARFGEF2, EMX2, SIX3, SRPX2
34acoustic neuroma9.0ARFGEF2, EMX2, HTRA1, NOTCH3, NOTCH4, SIX3

Comorbidity relations with Pseudobulbar Palsy via Phenotypic Disease Network (PDN):


Deficiency AnemiaParkinson Disease, Late-Onset
Protein-Energy MalnutritionAcute Cystitis
Cerebral AtherosclerosisDecubitus Ulcer
Epilepsy, Focal, with Speech Disorder and with or Without Mental RetardationHeart Disease
Hypertension, EssentialSwallowing Disorders
Transient Cerebral IschemiaSchizophreniform Disorder

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to pseudobulbar palsy

Symptoms & Phenotypes for Pseudobulbar Palsy

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UMLS symptoms related to Pseudobulbar Palsy:


hemiplegia, ophthalmoplegia, pseudobulbar signs, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.8ARFGEF2, EMX2, HTRA1, NOTCH3, NOTCH4, SIX3
2MP:00053917.6EMX2, HTRA1, NOTCH3, NOTCH4, SIX3

Drugs & Therapeutics for Pseudobulbar Palsy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Pseudobulbar Palsy


Cochrane evidence based reviews: pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

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Genetic tests related to Pseudobulbar Palsy:

id Genetic test Affiliating Genes
1 Pseudobulbar Paralysis27

Anatomical Context for Pseudobulbar Palsy

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MalaCards organs/tissues related to Pseudobulbar Palsy:

36
Tongue, Brain, Cerebellum, Trachea

Publications for Pseudobulbar Palsy

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Articles related to Pseudobulbar Palsy:

(show all 44)
idTitleAuthorsYear
1
Acute Pseudobulbar Palsy After Bilateral Paramedian Thalamic Infarction: A Case Report. (27606284)
2016
2
Pseudobulbar palsy due to bilateral injuries of corticobulbar tracts in a stroke patient. (26202710)
2015
3
Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy. (26185957)
2015
4
Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei. (25839917)
2015
5
Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. (24963673)
2014
6
Neurocysticercosis presenting as pseudobulbar palsy. (24741260)
2014
7
Pure pseudobulbar palsy due to a capsular infarction. (22504270)
2012
8
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)
2011
9
Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. (18305298)
2008
10
Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. (17078444)
2006
11
Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. (16771181)
2006
12
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. (16314998)
2005
13
Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. (15172029)
2004
14
Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. (17167648)
2002
15
Left atrial myxoma presenting as pseudobulbar palsy. (12134197)
2002
16
Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. (11848316)
2001
17
Pseudobulbar palsy recovery following HSV encephalitis in AIDS. (10726949)
2000
18
Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. (10965170)
2000
19
Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. (10453580)
1999
20
Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. (9926359)
1998
21
Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. (9153602)
1997
22
Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. (7750810)
1994
23
Pseudobulbar palsy associated with trismus. (7824418)
1994
24
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. (2011096)
1991
25
Pseudobulbar palsy: a clinical computed tomography study. (2298226)
1990
26
Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)
1989
27
Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. (2715610)
1989
28
Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (2738597)
1989
29
Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. (3366147)
1988
30
Neoplastic obstruction of the trachea complicating pseudobulbar palsy. (3406789)
1988
31
Trismus in pseudobulbar palsy. (4093375)
1985
32
Pseudobulbar palsy after carotid endarterectomy. (4047367)
1985
33
Pseudobulbar palsy after posterior fossa operation in children. (6504288)
1984
34
Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. (7129273)
1982
35
Lithium carbonate in pseudobulbar palsy. (6782937)
1981
36
Dysphagia of pseudobulbar palsy successfully treated by hypnosis. (6929999)
1980
37
Control of emotional expression in pseudobulbar palsy. A personal experience. (911237)
1977
38
Pseudobulbar palsy. (5419589)
1970
39
Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)
1967
40
SUPRANUCLEAR (PSEUDOBULBAR) PALSY. (14332003)
1965
41
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)
1964
42
SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". (14272249)
1963
43
Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. (14777908)
1950
44
Facial seborrhoea in arteriosclerotic pseudobulbar palsy. (18933673)
1948

Variations for Pseudobulbar Palsy

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Expression for genes affiliated with Pseudobulbar Palsy

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Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for genes affiliated with Pseudobulbar Palsy

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GO Terms for genes affiliated with Pseudobulbar Palsy

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Cellular components related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi membraneGO:00001399.1ARFGEF2, NOTCH3, NOTCH4

Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell differentiationGO:004559610.2NOTCH3, NOTCH4
2Notch receptor processingGO:000722010.1NOTCH3, NOTCH4
3negative regulation of neuron differentiationGO:004566510.0NOTCH3, SIX3
4forebrain developmentGO:003090010.0EMX2, NOTCH3
5cell proliferation in forebrainGO:00218469.8EMX2, SIX3
6Notch signaling pathwayGO:00072199.6NOTCH3, NOTCH4
7multicellular organism developmentGO:00072758.8EMX2, NOTCH3, NOTCH4, SIX3

Sources for Pseudobulbar Palsy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet