MCID: PSD001
MIFTS: 30

Pseudobulbar Palsy malady

Category: Neuronal diseases

Aliases & Classifications for Pseudobulbar Palsy

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Aliases & Descriptions for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy 10 12 36 65
 
Pseudobulbar Paralysis 10

Classifications:



External Ids:

Disease Ontology10 DOID:12680
ICD9CM29 335.23
SNOMED-CT59 7379000
MeSH36 D020828
UMLS65 C0033790

Summaries for Pseudobulbar Palsy

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Wikipedia:68 Pseudobulbar palsy is a medical condition characterised by the inability to control facial movements... more...

MalaCards based summary: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to macrogyria, pseudobulbar palsy and mental retardation and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy. An important gene associated with Pseudobulbar Palsy is NOTCH3 (Notch 3), and among its related pathways are Pre-NOTCH Expression and Processing and Thyroid hormone signaling pathway. Affiliated tissues include tongue, skeletal muscle and breast, and related mouse phenotype nervous system.

Related Diseases for Pseudobulbar Palsy

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Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to pseudobulbar palsy

Symptoms for Pseudobulbar Palsy

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Drugs & Therapeutics for Pseudobulbar Palsy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Pseudobulbar Palsy


Cochrane evidence based reviews: pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

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Anatomical Context for Pseudobulbar Palsy

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MalaCards organs/tissues related to Pseudobulbar Palsy:

33
Tongue, Skeletal muscle, Breast, Pituitary, Ovary, T cells, Testes

Animal Models for Pseudobulbar Palsy or affiliated genes

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MGI Mouse Phenotypes related to Pseudobulbar Palsy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.2ARFGEF2, EMX2, NOTCH3, NOTCH4, RAB3GAP1, SIX3

Publications for Pseudobulbar Palsy

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Articles related to Pseudobulbar Palsy:

(show all 43)
idTitleAuthorsYear
1
The HLA-B*4601-DRB1*0901 haplotype is positively correlated with juvenile ocular myasthenia gravis in a southern Chinese Han population. (25953150)
2015
2
Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling. (25450715)
2015
3
Overexpression of hiwi promotes growth of human breast cancer cells. (25292027)
2014
4
Increased levels of IgG antibodies against human HSP60 in patients with spondyloarthritis. (23424650)
2013
5
Acute compartment syndrome after extracorporeal membrane oxygenation. (24240730)
2013
6
The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A. (23994556)
2013
7
Abnormal activity-dependent brain lactate and glutamate+glutamine responses in panic disorder. (23332354)
2013
8
Reversal of central sleep apnea following discontinuation of opioids. (23066372)
2012
9
Clinical significance of tumor-associated macrophage infiltration in supraglottic laryngeal carcinoma. (21439250)
2011
10
Peripheral expression of key regulatory kinases in Alzheimer's disease and Parkinson's disease. (20106550)
2011
11
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. (21982832)
2011
12
Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein. (21211532)
2011
13
The use of dexamethasone in bacterial meningitis in children and adults: a retrospective analysis. (22389776)
2011
14
Large, symptomatic tension pneumocele: 23 years after translabyrinthine resection of an acoustic neuroma. (21493217)
2011
15
Chronic urticaria associated with recurrent genital herpes simplex infection and success of antiviral therapy--a report of two cases. (19699670)
2010
16
Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer. (19531654)
2009
17
PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3. (19644675)
2009
18
Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif. (19185514)
2009
19
Risk factors for postpartum depression: the role of the Postpartum Depression Predictors Inventory-Revised (PDPI-R). Results from the Perinatal Depression-Research & Screening Unit (PNDReScU) study. (19415454)
2009
20
Aromatase inhibitors in ovarian stimulation. (17604615)
2007
21
Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference. (16498393)
2006
22
High-throughput analysis of chromosome abnormality in spontaneous miscarriage using an MLPA subtelomere assay with an ancillary FISH test for polyploidy. (17106871)
2006
23
Protein-protein interaction and functionTRPC channels. (16044307)
2005
24
Long-term parathyroid- and c-cell function after radioiodine for benign thyroid diseases. (15943755)
2005
25
Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes. (14988236)
2004
26
Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies. (14730479)
2004
27
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. (15039426)
2004
28
Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene. (14714741)
2003
29
The role of tumor necrosis factor-alpha in the pathogenesis of aspiration pneumonitis in rats. (10443613)
1999
30
The subcellular location of the yeast Saccharomyces cerevisiae homologue of the protein defective in the juvenile form of Batten disease. (9753630)
1998
31
Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients. (9686625)
1998
32
Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP. (9182980)
1997
33
Functional integrity of granulosa cells from polycystic ovaries. (8762734)
1996
34
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. (7544399)
1995
35
Renal dysplasia and benign ureteropelvic polyps associated with hydronephrosis in a foal. (8014095)
1994
36
Induction of autoimmunity by immunization of mice with human thyrotropin receptor. (7923386)
1994
37
Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor. (1386024)
1992
38
Molecular analysis of T cell receptor and CD3 genes in CD3- large granular lymphocytes (LGLs): evidence for the existence of CD3- LGLs committed to the T cell lineage. (2167411)
1990
39
Epidemiology of sporotrichosis in Latin America. (2687693)
1989
40
Mycetoma in a grand Eclectus (Eclectus roratus roratus) parrot. (3729893)
1986
41
Gaucher's disease in a black child in South Africa. A case report. (6474303)
1984
42
Granular cell myoblastoma of the neurohypophysis. Report of two cases. (4328296)
1971
43
A kinship of the Roussy-Levy syndrome: a clinical and electrophysiological study. (5828526)
1964

Variations for Pseudobulbar Palsy

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Expression for genes affiliated with Pseudobulbar Palsy

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Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for genes affiliated with Pseudobulbar Palsy

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GO Terms for genes affiliated with Pseudobulbar Palsy

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Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1forebrain developmentGO:00309009.8EMX2, NOTCH3
2Notch receptor processingGO:00072209.6NOTCH3, NOTCH4
3Notch signaling pathwayGO:00072199.5NOTCH3, NOTCH4
4cell proliferation in forebrainGO:00218469.5EMX2, SIX3
5negative regulation of neuron differentiationGO:00456659.5NOTCH3, SIX3
6camera-type eye developmentGO:00430109.2RAB3GAP1, SIX3

Sources for Pseudobulbar Palsy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet