Aliases & Classifications for Pseudobulbar Palsy

MalaCards integrated aliases for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy 12 41 14 69
Pseudobulbar Paralysis 12 28

Classifications:



External Ids:

Disease Ontology 12 DOID:12680
ICD9CM 34 335.23
MeSH 41 D020828
SNOMED-CT 64 7379000
UMLS 69 C0033790

Summaries for Pseudobulbar Palsy

MalaCards based summary : Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 and kuzniecky andermann syndrome, and has symptoms including pseudobulbar behavioral symptoms, pseudobulbar signs and ophthalmoplegia. An important gene associated with Pseudobulbar Palsy is NOTCH3 (Notch 3), and among its related pathways/superpathways are Pre-NOTCH Expression and Processing and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include tongue, brain and cerebellum, and related phenotypes are growth/size/body region and vision/eye

Wikipedia : 72 Pseudobulbar palsy is a medical condition characterized by the inability to control facial movements... more...

Related Diseases for Pseudobulbar Palsy

Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 31.2 HTRA1 NOTCH3 NOTCH4
2 kuzniecky andermann syndrome 11.3
3 polymicrogyria, bilateral perisylvian, x-linked 11.1
4 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 11.1
5 motor neuron disease 11.1
6 dementia 10.1
7 dystonia 10.1
8 atypical choroid plexus papilloma 10.0 NOTCH3 NOTCH4
9 amyotrophic lateral sclerosis 1 10.0
10 supranuclear palsy, progressive, 1 10.0
11 epilepsy 10.0
12 lateral sclerosis 10.0
13 dysphagia 10.0
14 classic progressive supranuclear palsy syndrome 10.0
15 chorioretinal scar 10.0 NOTCH3 NOTCH4
16 hajdu-cheney syndrome 9.9 NOTCH3 NOTCH4
17 malaria 9.9
18 cerebritis 9.9
19 venous malformations, multiple cutaneous and mucosal 9.8 NOTCH3 NOTCH4
20 creutzfeldt-jakob disease 9.8
21 meningioma, familial 9.8
22 leukemia 9.8
23 sleeping sickness 9.8
24 trypanosomiasis 9.8
25 endocarditis 9.8
26 antiphospholipid syndrome 9.8
27 progressive multifocal leukoencephalopathy 9.8
28 petroclival meningioma 9.8
29 neuronitis 9.8
30 speech disorder 9.8
31 encephalitis 9.8
32 trypanosomiasis, human east-african 9.8
33 encephalopathy 9.8
34 neuronal migration disorders 9.8
35 cerebral degeneration 9.7 HTRA1 NOTCH3 NOTCH4
36 congenital nervous system abnormality 9.5 ARFGEF2 SIX3
37 periventricular nodular heterotopia 9.5 ARFGEF2 SIX3 SRPX2

Comorbidity relations with Pseudobulbar Palsy via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Cerebral Atherosclerosis
Decubitus Ulcer Deficiency Anemia
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Heart Disease
Hypertension, Essential Parkinson Disease, Late-Onset
Protein-Energy Malnutrition Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to Pseudobulbar Palsy

Symptoms & Phenotypes for Pseudobulbar Palsy

UMLS symptoms related to Pseudobulbar Palsy:


pseudobulbar behavioral symptoms, pseudobulbar signs, ophthalmoplegia, hemiplegia

MGI Mouse Phenotypes related to Pseudobulbar Palsy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.43 HTRA1 KIF1BP NOTCH3 NOTCH4 SIX3 ARFGEF2
2 vision/eye MP:0005391 9.02 HTRA1 KIF1BP NOTCH3 NOTCH4 SIX3

Drugs & Therapeutics for Pseudobulbar Palsy

Search Clinical Trials , NIH Clinical Center for Pseudobulbar Palsy

Cochrane evidence based reviews: pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

Genetic tests related to Pseudobulbar Palsy:

# Genetic test Affiliating Genes
1 Pseudobulbar Paralysis 28

Anatomical Context for Pseudobulbar Palsy

MalaCards organs/tissues related to Pseudobulbar Palsy:

38
Tongue, Brain, Cerebellum, Trachea

Publications for Pseudobulbar Palsy

Articles related to Pseudobulbar Palsy:

(show all 45)
# Title Authors Year
1
Hashimoto's encephalopathy presenting as pseudobulbar palsy. ( 29368307 )
2018
2
Acute Pseudobulbar Palsy After Bilateral Paramedian Thalamic Infarction: A Case Report. ( 27606284 )
2016
3
Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei. ( 25839917 )
2015
4
Pseudobulbar palsy due to bilateral injuries of corticobulbar tracts in a stroke patient. ( 26202710 )
2015
5
Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy. ( 26185957 )
2015
6
Neurocysticercosis presenting as pseudobulbar palsy. ( 24741260 )
2014
7
Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. ( 24963673 )
2014
8
Pure pseudobulbar palsy due to a capsular infarction. ( 22504270 )
2012
9
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. ( 21217721 )
2011
10
Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. ( 18305298 )
2008
11
Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. ( 16771181 )
2006
12
Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. ( 17078444 )
2006
13
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. ( 16314998 )
2005
14
Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. ( 15172029 )
2004
15
Left atrial myxoma presenting as pseudobulbar palsy. ( 12134197 )
2002
16
Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. ( 17167648 )
2002
17
Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. ( 11848316 )
2001
18
Pseudobulbar palsy recovery following HSV encephalitis in AIDS. ( 10726949 )
2000
19
Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. ( 10965170 )
2000
20
Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. ( 10453580 )
1999
21
Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. ( 9926359 )
1998
22
Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. ( 9153602 )
1997
23
Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. ( 7750810 )
1994
24
Pseudobulbar palsy associated with trismus. ( 7824418 )
1994
25
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. ( 2011096 )
1991
26
Pseudobulbar palsy: a clinical computed tomography study. ( 2298226 )
1990
27
Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. ( 2500888 )
1989
28
Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. ( 2715610 )
1989
29
Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? ( 2738597 )
1989
30
Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. ( 3366147 )
1988
31
Neoplastic obstruction of the trachea complicating pseudobulbar palsy. ( 3406789 )
1988
32
Pseudobulbar palsy after carotid endarterectomy. ( 4047367 )
1985
33
Trismus in pseudobulbar palsy. ( 4093375 )
1985
34
Pseudobulbar palsy after posterior fossa operation in children. ( 6504288 )
1984
35
Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. ( 7129273 )
1982
36
Lithium carbonate in pseudobulbar palsy. ( 6782937 )
1981
37
Dysphagia of pseudobulbar palsy successfully treated by hypnosis. ( 6929999 )
1980
38
Control of emotional expression in pseudobulbar palsy. A personal experience. ( 911237 )
1977
39
Pseudobulbar palsy. ( 5419589 )
1970
40
Bacterial endocarditis presenting as pseudobulbar palsy. ( 6053619 )
1967
41
SUPRANUCLEAR (PSEUDOBULBAR) PALSY. ( 14332003 )
1965
42
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. ( 14107684 )
1964
43
SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". ( 14272249 )
1963
44
Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. ( 14777908 )
1950
45
Facial seborrhoea in arteriosclerotic pseudobulbar palsy. ( 18933673 )
1948

Variations for Pseudobulbar Palsy

Expression for Pseudobulbar Palsy

Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for Pseudobulbar Palsy

GO Terms for Pseudobulbar Palsy

Cellular components related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.8 ARFGEF2 NOTCH3 NOTCH4

Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.62 KIF1BP NOTCH3 NOTCH4 SIX3
2 Notch signaling pathway GO:0007219 9.37 NOTCH3 NOTCH4
3 negative regulation of cell differentiation GO:0045596 9.26 NOTCH3 NOTCH4
4 negative regulation of neuron differentiation GO:0045665 9.16 NOTCH3 SIX3
5 Notch receptor processing GO:0007220 8.96 NOTCH3 NOTCH4
6 regulation of developmental process GO:0050793 8.62 NOTCH3 NOTCH4

Sources for Pseudobulbar Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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