Pseudobulbar Palsy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Pseudobulbar Palsy

Sources:
¹¹Disease Ontology, ¹³DISEASES, ²⁷GTR, ³²ICD9CM, ³⁹MeSH, ⁶²SNOMED-CT, ⁶⁸UMLS
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Aliases & Descriptions for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy ¹¹ ³⁹ ¹³ ⁶⁸

Pseudobulbar Paralysis ¹¹ ²⁷

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology¹¹ DOID:12680

ICD9CM³² 335.23

SNOMED-CT⁶² 7379000

MeSH³⁹ D020828

UMLS⁶⁸ C0033790

Summaries for Pseudobulbar Palsy

Sources:
³⁶MalaCards, ⁷¹Wikipedia
See all MalaCards sources

Wikipedia:⁷¹ Pseudobulbar palsy is a medical condition characterized by the inability to control facial movements... more...

MalaCards based summary: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to macrogyria, pseudobulbar palsy and mental retardation and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, and has symptoms including hemiplegia, hemiplegia and ophthalmoplegia. An important gene associated with Pseudobulbar Palsy is SRPX2 (Sushi Repeat Containing Protein, X-Linked 2), and among its related pathways are Thyroid hormone signaling pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include tongue, brain and cerebellum, and related mouse phenotypes are growth/size/body region and vision/eye.

Related Diseases for Pseudobulbar Palsy

Sources:
²⁰GeneAnalytics, ²¹GeneCards, ⁶⁸UMLS
See all MalaCards sources

Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)

id	Related Disease	Score	Top Affiliating Genes
1	macrogyria, pseudobulbar palsy and mental retardation	12.0
2	cerebral arteriopathy with subcortical infarcts and leukoencephalopathy	11.0
3	motor neuron disease	11.0
4	cadasil 2	11.0
5	duodenal obstruction	10.1	NOTCH3, NOTCH4
6	bartonellosis	10.1	NOTCH3, NOTCH4
7	dementia	10.0
8	dystonia	10.0
9	phosphoglycerate dehydrogenase deficiency	10.0	NOTCH3, NOTCH4
10	sclerosing keratitis	9.9	HTRA1, NOTCH3, NOTCH4
11	hyperostosis	9.9	SIX3, SRPX2
12	epilepsy	9.9
13	lateral sclerosis	9.9
14	dysphagia	9.9
15	fga-related congenital afibrinogenemia	9.9	EMX2, SIX3
16	persistent vegetative state	9.9	ARFGEF2, EMX2
17	acromesomelic dysplasia, maroteaux type	9.9	NOTCH3, NOTCH4
18	gastrointestinal defects and immunodeficiency syndrome	9.9	EMX2, SIX3
19	angiodysplasia	9.8	ARFGEF2, SIX3
20	malaria	9.8
21	cerebritis	9.8
22	creutzfeldt-jakob disease	9.8
23	leukemia	9.8
24	trypanosomiasis	9.8
25	endocarditis	9.8
26	antiphospholipid syndrome	9.8
27	progressive multifocal leukoencephalopathy	9.8
28	petroclival meningioma	9.8
29	neuronitis	9.8
30	speech disorder	9.8
31	encephalitis	9.8
32	neuronal migration disorders	9.8
33	otopalatodigital syndrome, type ii	9.5	ARFGEF2, EMX2, SIX3, SRPX2
34	acoustic neuroma	9.0	ARFGEF2, EMX2, HTRA1, NOTCH3, NOTCH4, SIX3

Comorbidity relations with Pseudobulbar Palsy via Phenotypic Disease Network (PDN):

Deficiency Anemia	Parkinson Disease, Late-Onset
Protein-Energy Malnutrition	Acute Cystitis
Cerebral Atherosclerosis	Decubitus Ulcer
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation	Heart Disease
Hypertension, Essential	Swallowing Disorders
Transient Cerebral Ischemia	Schizophreniform Disorder

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:

Symptoms & Phenotypes for Pseudobulbar Palsy

Sources:
⁴¹MGI, ⁶⁸UMLS
See all MalaCards sources

UMLS symptoms related to Pseudobulbar Palsy:

hemiplegia, ophthalmoplegia, pseudobulbar signs, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	7.8	ARFGEF2, EMX2, HTRA1, NOTCH3, NOTCH4, SIX3
2	vision/eye	MP:0005391	7.6	EMX2, HTRA1, NOTCH3, NOTCH4, SIX3

Drugs & Therapeutics for Pseudobulbar Palsy

Sources:
⁴ClinicalTrials, ⁷Cochrane Library
See all MalaCards sources

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Pseudobulbar Palsy

Cochrane evidence based reviews: pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

Sources:
²⁷GTR
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Genetic tests related to Pseudobulbar Palsy:

id	Genetic test	Affiliating Genes
1	Pseudobulbar Paralysis²⁷

Anatomical Context for Pseudobulbar Palsy

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Pseudobulbar Palsy:

³⁶

Tongue, Brain, Cerebellum, Trachea

Publications for Pseudobulbar Palsy

Sources:
⁵⁷PubMed
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Articles related to Pseudobulbar Palsy:

(show all 44)

id	Title	Authors	Year
1	Acute Pseudobulbar Palsy After Bilateral Paramedian Thalamic Infarction: A Case Report. (27606284)	Lee H.Y.... Lee J.	2016
2	Pseudobulbar palsy due to bilateral injuries of corticobulbar tracts in a stroke patient. (26202710)	Jang S.H.... Seo J.P.	2015
3	Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy. (26185957)	Stocker A.... Huttner H.B.	2015
4	Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei. (25839917)	Nicastro N.... Horvath J.	2015
5	Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. (24963673)	Steele J.C.... Olszewski J.	2014
6	Neurocysticercosis presenting as pseudobulbar palsy. (24741260)	Kumar A.S.... Subrahmanyam D.K.	2014
7	Pure pseudobulbar palsy due to a capsular infarction. (22504270)	Maeda K.... Shiraishi T.	2012
8	Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)	FROST L.	2011
9	Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. (18305298)	Graham K.C.... Spiegel D.R.	2008
10	Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. (17078444)	Hong C.	2006
11	Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. (16771181)	Kim H.I.... Kim S.U.	2006
12	Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. (16314998)	Kinirons P.... Murphy R.P.	2005
13	Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. (15172029)	Arboix A.... Sans-Sabrafen J.	2004
14	Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. (17167648)	McCormick W.E.... Lee J.H.	2002
15	Left atrial myxoma presenting as pseudobulbar palsy. (12134197)	Kumar A.... Malhotra H.S.	2002
16	Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. (11848316)	Aleem M.A.... Jayapal V.	2001
17	Pseudobulbar palsy recovery following HSV encephalitis in AIDS. (10726949)	Kulasegaram R.... Rodgers C.A.	2000
18	Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. (10965170)	Frank H.G.... Landis T.	2000
19	Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. (10453580)	Shi X.... Zhang H.	1999
20	Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. (9926359)	Leroy-Malherbe V.... Arabia C.	1998
21	Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. (9153602)	Abrahams S.... Leigh P.N.	1997
22	Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. (7750810)	Karacostas D.... Bogousslavsky J.	1994
23	Pseudobulbar palsy associated with trismus. (7824418)	Lai M.M.... Howard R.S.	1994
24	Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. (2011096)	Shaw P.J.... Stevens M.M.	1991
25	Pseudobulbar palsy: a clinical computed tomography study. (2298226)	Loeb C.... Del Sette M.	1990
26	Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)	Kuzniecky R.... Leppik I.	1989
27	Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. (2715610)	Grattan-Smith P.J.... Boldt D.W.	1989
28	Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (2738597)	Asfora W.T.... Kjellberg R.N.	1989
29	Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. (3366147)	Mancardi G.L.... Loeb C.	1988
30	Neoplastic obstruction of the trachea complicating pseudobulbar palsy. (3406789)	Aumentado D.J.... Payne C.B.	1988
31	Trismus in pseudobulbar palsy. (4093375)	Dhamija R.M.... Maheshwari M.C.	1985
32	Pseudobulbar palsy after carotid endarterectomy. (4047367)	Solomon R.A.... Correll J.W.	1985
33	Pseudobulbar palsy after posterior fossa operation in children. (6504288)	Wisoff J.H.... Epstein F.J.	1984
34	Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. (7129273)	Hirose H.... Sawashima M.	1982
35	Lithium carbonate in pseudobulbar palsy. (6782937)	Massey E.W.... Lowe S.	1981
36	Dysphagia of pseudobulbar palsy successfully treated by hypnosis. (6929999)	Black S.	1980
37	Control of emotional expression in pseudobulbar palsy. A personal experience. (911237)	Lieberman A.... Benson D.F.	1977
38	Pseudobulbar palsy. (5419589)	Flora G.C.	1970
39	Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)	Shafar J.	1967
40	SUPRANUCLEAR (PSEUDOBULBAR) PALSY. (14332003)	Aring C.D.	1965
41	PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)	Steele J.C.... Olszewski J.	1964
42	SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". (14272249)	Richardson J.C.... Olszewski J.	1963
43	Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. (14777908)	HEATHFIELD K.W.... JEWESBURY E.C.	1950
44	Facial seborrhoea in arteriosclerotic pseudobulbar palsy. (18933673)	ELLIOTT F.A.	1948

Genes related to Pseudobulbar Palsy

Sources:
¹³DISEASES, ²¹GeneCards
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Genes related to Pseudobulbar Palsy:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	SRPX2	Sushi Repeat Containing Protein, X-Linked 2	26.46	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
2	NOTCH3	Notch 3	25.80	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
3	NOTCH4	Notch 4	25.26	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
4	ARFGEF2	ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2	24.04	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
5	SIX3	SIX Homeobox 3	23.92	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
6	EMX2	Empty Spiracles Homeobox 2	23.64	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
7	HTRA1	HtrA Serine Peptidase 1	23.06	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)

Variations for Pseudobulbar Palsy

Expression for genes affiliated with Pseudobulbar Palsy

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for genes affiliated with Pseudobulbar Palsy

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁹R&D Systems
See all MalaCards sources

Pathways related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Thyroid hormone signaling pathway³⁴	9.6	NOTCH3, NOTCH4
2	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁹	9.6	NOTCH3, NOTCH4
3	Neural Crest Differentiation⁴²	9.6	NOTCH3, NOTCH4
4	Angiogenesis (CST)³ Show member pathways Angiogenesis³	9.6	NOTCH3, NOTCH4
5	Dorso-ventral axis formation³⁴	9.6	NOTCH3, NOTCH4
6	Canonical and Non-canonical Notch signaling⁴²	9.6	NOTCH3, NOTCH4

GO Terms for genes affiliated with Pseudobulbar Palsy

Sources:
¹⁹Gene Ontology
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Cellular components related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi membrane	GO:0000139	9.1	ARFGEF2, NOTCH3, NOTCH4

Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell differentiation	GO:0045596	10.2	NOTCH3, NOTCH4
2	Notch receptor processing	GO:0007220	10.1	NOTCH3, NOTCH4
3	negative regulation of neuron differentiation	GO:0045665	10.0	NOTCH3, SIX3
4	forebrain development	GO:0030900	10.0	EMX2, NOTCH3
5	cell proliferation in forebrain	GO:0021846	9.8	EMX2, SIX3
6	Notch signaling pathway	GO:0007219	9.6	NOTCH3, NOTCH4
7	multicellular organism development	GO:0007275	8.8	EMX2, NOTCH3, NOTCH4, SIX3