Aliases & Classifications for Pseudobulbar Palsy

MalaCards integrated aliases for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy 12 42 14 69
Pseudobulbar Paralysis 12 29

Classifications:



External Ids:

Disease Ontology 12 DOID:12680
ICD9CM 35 335.23
MeSH 42 D020828
SNOMED-CT 64 7379000
UMLS 69 C0033790

Summaries for Pseudobulbar Palsy

MalaCards based summary : Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to macrogyria, pseudobulbar palsy and mental retardation and motor neuron disease, and has symptoms including hemiplegia, ophthalmoplegia and pseudobulbar signs. An important gene associated with Pseudobulbar Palsy is NOTCH3 (Notch 3), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Thyroid hormone signaling pathway. Affiliated tissues include tongue, brain and cerebellum, and related phenotypes are growth/size/body region and vision/eye

Wikipedia : 72 Pseudobulbar palsy is a medical condition characterized by the inability to control facial movements... more...

Related Diseases for Pseudobulbar Palsy

Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
id Related Disease Score Top Affiliating Genes
1 macrogyria, pseudobulbar palsy and mental retardation 12.0
2 motor neuron disease 11.0
3 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 11.0
4 cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 11.0
5 superior mesenteric artery syndrome 10.0 NOTCH3 NOTCH4
6 dementia 10.0
7 dystonia 10.0
8 trench fever 10.0 NOTCH3 NOTCH4
9 dysphagia 9.9
10 epilepsy 9.9
11 lateral sclerosis 9.9
12 hajdu-cheney syndrome 9.9 NOTCH3 NOTCH4
13 cerebritis 9.8
14 malaria 9.8
15 leukemia 9.8
16 neuronal migration disorders 9.8
17 trypanosomiasis 9.8
18 endocarditis 9.8
19 antiphospholipid syndrome 9.8
20 progressive multifocal leukoencephalopathy 9.8
21 petroclival meningioma 9.8
22 neuronitis 9.8
23 speech disorder 9.8
24 encephalitis 9.8
25 creutzfeldt-jakob disease 9.8
26 myofibromatosis, infantile 2 9.7 HTRA1 NOTCH3 NOTCH4
27 angiodysplasia 9.7 ARFGEF2 SIX3
28 sclerosing keratitis 9.7 HTRA1 NOTCH3 NOTCH4
29 glaucoma 3, primary congenital, e 9.7 NOTCH3 NOTCH4
30 otopalatodigital syndrome, type ii 9.4 ARFGEF2 SIX3 SRPX2
31 acoustic neuroma 7.3 ARFGEF2 HTRA1 KIF1BP NOTCH3 NOTCH4 SIX3

Comorbidity relations with Pseudobulbar Palsy via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Cerebral Atherosclerosis
Decubitus Ulcer Deficiency Anemia
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Heart Disease
Hypertension, Essential Parkinson Disease, Late-Onset
Protein-Energy Malnutrition Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to Pseudobulbar Palsy

Symptoms & Phenotypes for Pseudobulbar Palsy

UMLS symptoms related to Pseudobulbar Palsy:


hemiplegia, ophthalmoplegia, pseudobulbar signs, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Pseudobulbar Palsy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.35 ARFGEF2 HTRA1 NOTCH3 NOTCH4 SIX3
2 vision/eye MP:0005391 8.92 HTRA1 NOTCH3 NOTCH4 SIX3

Drugs & Therapeutics for Pseudobulbar Palsy

Search Clinical Trials , NIH Clinical Center for Pseudobulbar Palsy

Cochrane evidence based reviews: pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

Genetic tests related to Pseudobulbar Palsy:

id Genetic test Affiliating Genes
1 Pseudobulbar Paralysis 29

Anatomical Context for Pseudobulbar Palsy

MalaCards organs/tissues related to Pseudobulbar Palsy:

39
Tongue, Brain, Cerebellum, Trachea

Publications for Pseudobulbar Palsy

Articles related to Pseudobulbar Palsy:

(show all 44)
id Title Authors Year
1
Acute Pseudobulbar Palsy After Bilateral Paramedian Thalamic Infarction: A Case Report. ( 27606284 )
2016
2
Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy. ( 26185957 )
2015
3
Pseudobulbar palsy due to bilateral injuries of corticobulbar tracts in a stroke patient. ( 26202710 )
2015
4
Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei. ( 25839917 )
2015
5
Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. ( 24963673 )
2014
6
Neurocysticercosis presenting as pseudobulbar palsy. ( 24741260 )
2014
7
Pure pseudobulbar palsy due to a capsular infarction. ( 22504270 )
2012
8
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. ( 21217721 )
2011
9
Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. ( 18305298 )
2008
10
Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. ( 17078444 )
2006
11
Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. ( 16771181 )
2006
12
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. ( 16314998 )
2005
13
Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. ( 15172029 )
2004
14
Left atrial myxoma presenting as pseudobulbar palsy. ( 12134197 )
2002
15
Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. ( 17167648 )
2002
16
Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. ( 11848316 )
2001
17
Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. ( 10965170 )
2000
18
Pseudobulbar palsy recovery following HSV encephalitis in AIDS. ( 10726949 )
2000
19
Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. ( 10453580 )
1999
20
Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. ( 9926359 )
1998
21
Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. ( 9153602 )
1997
22
Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. ( 7750810 )
1994
23
Pseudobulbar palsy associated with trismus. ( 7824418 )
1994
24
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. ( 2011096 )
1991
25
Pseudobulbar palsy: a clinical computed tomography study. ( 2298226 )
1990
26
Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. ( 2715610 )
1989
27
Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? ( 2738597 )
1989
28
Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. ( 2500888 )
1989
29
Neoplastic obstruction of the trachea complicating pseudobulbar palsy. ( 3406789 )
1988
30
Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. ( 3366147 )
1988
31
Pseudobulbar palsy after carotid endarterectomy. ( 4047367 )
1985
32
Trismus in pseudobulbar palsy. ( 4093375 )
1985
33
Pseudobulbar palsy after posterior fossa operation in children. ( 6504288 )
1984
34
Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. ( 7129273 )
1982
35
Lithium carbonate in pseudobulbar palsy. ( 6782937 )
1981
36
Dysphagia of pseudobulbar palsy successfully treated by hypnosis. ( 6929999 )
1980
37
Control of emotional expression in pseudobulbar palsy. A personal experience. ( 911237 )
1977
38
Pseudobulbar palsy. ( 5419589 )
1970
39
Bacterial endocarditis presenting as pseudobulbar palsy. ( 6053619 )
1967
40
SUPRANUCLEAR (PSEUDOBULBAR) PALSY. ( 14332003 )
1965
41
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. ( 14107684 )
1964
42
SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". ( 14272249 )
1963
43
Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. ( 14777908 )
1950
44
Facial seborrhoea in arteriosclerotic pseudobulbar palsy. ( 18933673 )
1948

Variations for Pseudobulbar Palsy

Expression for Pseudobulbar Palsy

Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for Pseudobulbar Palsy

Pathways related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.39 NOTCH3 NOTCH4
2 11.32 NOTCH3 NOTCH4
3 11.16 NOTCH3 NOTCH4
4 10.9 NOTCH3 NOTCH4
5 10.05 NOTCH3 NOTCH4

GO Terms for Pseudobulbar Palsy

Cellular components related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.8 ARFGEF2 NOTCH3 NOTCH4

Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.56 KIF1BP NOTCH3 NOTCH4 SIX3
2 Notch signaling pathway GO:0007219 9.32 NOTCH3 NOTCH4
3 negative regulation of cell differentiation GO:0045596 9.16 NOTCH3 NOTCH4
4 negative regulation of neuron differentiation GO:0045665 8.96 NOTCH3 SIX3
5 Notch receptor processing GO:0007220 8.62 NOTCH3 NOTCH4

Sources for Pseudobulbar Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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