Pseudobulbar Palsy disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Aliases & Classifications for Pseudobulbar Palsy

Sources:
¹⁰Disease Ontology, ¹²DISEASES, ³⁶MeSH, ⁶⁵UMLS, ²⁹ICD9CM, ⁵⁹SNOMED-CT
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Aliases & Descriptions for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy ¹⁰ ¹² ³⁶ ⁶⁵

Pseudobulbar Paralysis ¹⁰

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology¹⁰ DOID:12680

ICD9CM²⁹ 335.23

SNOMED-CT⁵⁹ 7379000

MeSH³⁶ D020828

UMLS⁶⁵ C0033790

Summaries for Pseudobulbar Palsy

Sources:
⁶⁸Wikipedia, ³³MalaCards
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Wikipedia:⁶⁸ Pseudobulbar palsy is a medical condition characterised by the inability to control facial movements... more...

MalaCards based summary: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to macrogyria, pseudobulbar palsy and mental retardation and childhood choroid plexus cancer, and has symptoms including pseudobulbar behavioral symptoms, pseudobulbar signs and paresis anal sphincter. An important gene associated with Pseudobulbar Palsy is NOTCH3 (Notch 3), and among its related pathways are Pre-NOTCH Expression and Processing and Thyroid hormone signaling pathway. Affiliated tissues include tongue, t cells and breast, and related mouse phenotype nervous system.

Related Diseases for Pseudobulbar Palsy

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics, ⁶⁵UMLS
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Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)

id	Related Disease	Score	Top Affiliating Genes
1	macrogyria, pseudobulbar palsy and mental retardation	12.2
2	childhood choroid plexus cancer	10.3	NOTCH3, NOTCH4
3	q fever	10.2	NOTCH3, NOTCH4
4	hajdu-cheney syndrome	10.2	NOTCH3, NOTCH4
5	dementia	10.1
6	dystonia	10.1
7	retinitis pigmentosa 31	10.1	NOTCH3, NOTCH4
8	cerebral arteriopathy with subcortical infarcts and leukoencephalopathy	10.1
9	motor neuron disease	10.1
10	neurosarcoidosis	10.1	ARFGEF2, EMX2
11	lateral sclerosis	10.0
12	dysphagia	10.0
13	chronic tubotympanic suppurative otitis media	10.0	NOTCH3, NOTCH4
14	albinism, oculocutaneous, type v	10.0	NOTCH3, NOTCH4
15	enthesopathy	10.0	SIX3, SRPX2
16	bladder neck obstruction	9.9	NOTCH3, NOTCH4
17	malaria	9.9
18	cerebritis	9.9
19	creutzfeldt-jakob disease	9.9
20	leukemia	9.9
21	trypanosomiasis	9.9
22	endocarditis	9.9
23	antiphospholipid syndrome	9.9
24	ophthalmoplegia	9.9
25	progressive multifocal leukoencephalopathy	9.9
26	petroclival meningioma	9.9
27	neuronitis	9.9
28	speech disorder	9.9
29	encephalitis	9.9
30	neuronal migration disorders	9.9
31	schizencephaly	9.8	EMX2, SIX3
32	female breast cancer	9.6	RAB3GAP1, SIX3
33	sensory peripheral neuropathy	9.4	ARFGEF2, SIX3
34	hyperphosphatemia	9.1	ARFGEF2, EMX2, SIX3, SRPX2
35	vestibular neuronitis	7.5	ARFGEF2, EMX2, NOTCH3, NOTCH4, RAB3GAP1, SIX3

Comorbidity relations with Pseudobulbar Palsy via Phenotypic Disease Network (PDN):

Hypertension, Essential	Parkinson Disease, Late-Onset
Deficiency Anemia	Aphasia
Schizophreniform Disorder	Heart Disease
Protein-Energy Malnutrition	Cerebral Atherosclerosis
Acute Cystitis	Transient Cerebral Ischemia
Decubitus Ulcer	Swallowing Disorders

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:

Symptoms for Pseudobulbar Palsy

Sources:
⁶⁵UMLS
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UMLS symptoms related to Pseudobulbar Palsy:

pseudobulbar behavioral symptoms, pseudobulbar signs, paresis anal sphincter, monoparesis, quadriparesis, todd paralysis, paraparesis, paresis, ophthalmoplegia, hemiplegia, hemiparesis

Drugs & Therapeutics for Pseudobulbar Palsy

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶Cochrane Library
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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Pseudobulbar Palsy

Cochrane evidence based reviews: pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

Anatomical Context for Pseudobulbar Palsy

Sources:
³³MalaCards
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MalaCards organs/tissues related to Pseudobulbar Palsy:

³³

Tongue, T cells, Breast, Ovary, Testes, Pituitary, Endothelial

Animal Models for Pseudobulbar Palsy or affiliated genes

Sources:
³⁸MGI
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MGI Mouse Phenotypes related to Pseudobulbar Palsy:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	7.2	ARFGEF2, EMX2, NOTCH3, NOTCH4, RAB3GAP1, SIX3

Publications for Pseudobulbar Palsy

Sources:
⁵⁴PubMed
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Articles related to Pseudobulbar Palsy:

(show all 43)

id	Title	Authors	Year
1	Pseudobulbar palsy due to bilateral injuries of corticobulbar tracts in a stroke patient. (26202710)	Jang S.H.... Seo J.P.	2015
2	Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy. (26185957)	Stocker A.... Huttner H.B.	2015
3	Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei. (25839917)	Nicastro N.... Horvath J.	2015
4	Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. (24963673)	Steele J.C.... Olszewski J.	2014
5	Neurocysticercosis presenting as pseudobulbar palsy. (24741260)	Kumar A.S.... Subrahmanyam D.K.	2014
6	Pure pseudobulbar palsy due to a capsular infarction. (22504270)	Maeda K.... Shiraishi T.	2012
7	Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)	Frost L.	2011
8	Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. (18305298)	Graham K.C.... Spiegel D.R.	2008
9	Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. (17078444)	Hong C.	2006
10	Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. (16771181)	Kim H.I.... Kim S.U.	2006
11	Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. (16314998)	Kinirons P.... Murphy R.P.	2005
12	Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. (15172029)	Arboix A.... Sans-Sabrafen J.	2004
13	Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. (17167648)	McCormick W.E.... Lee J.H.	2002
14	Left atrial myxoma presenting as pseudobulbar palsy. (12134197)	Kumar A.... Malhotra H.S.	2002
15	Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. (11848316)	Aleem M.A.... Jayapal V.	2001
16	Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. (10965170)	Frank H.G.... Landis T.	2000
17	Pseudobulbar palsy recovery following HSV encephalitis in AIDS. (10726949)	Kulasegaram R.... Rodgers C.A.	2000
18	Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. (10453580)	Shi X.... Zhang H.	1999
19	Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. (9926359)	Leroy-Malherbe V.... Arabia C.	1998
20	Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. (9153602)	Abrahams S.... Leigh P.N.	1997
21	Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. (7750810)	Karacostas D.... Bogousslavsky J.	1994
22	Pseudobulbar palsy associated with trismus. (7824418)	Lai M.M.... Howard R.S.	1994
23	Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. (2011096)	Shaw P.J.... Stevens M.M.	1991
24	Pseudobulbar palsy: a clinical computed tomography study. (2298226)	Loeb C.... Del Sette M.	1990
25	Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. (2715610)	Grattan-Smith P.J.... Boldt D.W.	1989
26	Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (2738597)	Asfora W.T.... Kjellberg R.N.	1989
27	Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)	Kuzniecky R.... Leppik I.	1989
28	Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. (3366147)	Mancardi G.L.... Loeb C.	1988
29	Neoplastic obstruction of the trachea complicating pseudobulbar palsy. (3406789)	Aumentado D.J.... Payne C.B.	1988
30	Trismus in pseudobulbar palsy. (4093375)	Dhamija R.M.... Maheshwari M.C.	1985
31	Pseudobulbar palsy after carotid endarterectomy. (4047367)	Solomon R.A.... Correll J.W.	1985
32	Pseudobulbar palsy after posterior fossa operation in children. (6504288)	Wisoff J.H.... Epstein F.J.	1984
33	Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. (7129273)	Hirose H.... Sawashima M.	1982
34	Lithium carbonate in pseudobulbar palsy. (6782937)	Massey E.W.... Lowe S.	1981
35	Dysphagia of pseudobulbar palsy successfully treated by hypnosis. (6929999)	Black S.	1980
36	Control of emotional expression in pseudobulbar palsy. A personal experience. (911237)	Lieberman A.... Benson D.F.	1977
37	Pseudobulbar palsy. (5419589)	Flora G.C.	1970
38	Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)	SHAFAR J.	1967
39	SUPRANUCLEAR (PSEUDOBULBAR) PALSY. (14332003)	ARING C.D.	1965
40	PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)	Steele J.C.... Olszewski J.	1964
41	SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". (14272249)	Richardson J.C.... Olszewski J.	1963
42	Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. (14777908)	HEATHFIELD K.W.... JEWESBURY E.C.	1950
43	Facial seborrhoea in arteriosclerotic pseudobulbar palsy. (18933673)	ELLIOTT F.A.	1948

Genes related to Pseudobulbar Palsy

Sources:
²⁰GeneCards, ¹²DISEASES
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Genes related to Pseudobulbar Palsy:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	NOTCH3	Notch 3	25.92	DISEASES inferred ¹² GeneCards inferred via : Disorders (show sections)
2	SRPX2	Sushi Repeat Containing Protein, X-Linked 2	18.31	DISEASES inferred ¹²
3	NOTCH4	Notch 4	16.97	DISEASES inferred ¹²
4	ARFGEF2	ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2	15.86	DISEASES inferred ¹²
5	SIX3	SIX Homeobox 3	15.76	DISEASES inferred ¹²
6	RAB3GAP1	RAB3 GTPase Activating Protein Catalytic Subunit 1	15.48	DISEASES inferred ¹²
7	EMX2	Empty Spiracles Homeobox 2	15.43	DISEASES inferred ¹²

Variations for Pseudobulbar Palsy

Expression for genes affiliated with Pseudobulbar Palsy

Sources:
¹⁷Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for genes affiliated with Pseudobulbar Palsy

Sources:
⁵²PathCards, ⁵⁷Reactome, ³¹KEGG, ⁵⁶R&D Systems, ³⁹NCBI BioSystems Database
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Pathways related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Pre-NOTCH Expression and Processing⁵⁷ Show member pathways Pre-NOTCH Processing in Golgi⁵⁷ Pre-NOTCH Transcription and Translation⁵⁷ Pre-NOTCH Processing in the Endoplasmic Reticulum⁵⁷ Notch-HLH transcription pathway⁵⁷ Post-transcriptional silencing by small RNAs⁵⁷ Defective LFNG causes SCDO3⁵⁷	9.6	NOTCH3, NOTCH4
2	Thyroid hormone signaling pathway³¹	9.6	NOTCH3, NOTCH4
3	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁶	9.6	NOTCH3, NOTCH4
4	Neural Crest Differentiation³⁹	9.6	NOTCH3, NOTCH4
5	Notch signaling pathway (Pathway Interaction Database)³⁹ Show member pathways Notch signaling pathway³⁹	9.6	NOTCH3, NOTCH4
6	Notch Signaling Pathways⁵⁶	9.6	NOTCH3, NOTCH4
7	Dorso-ventral axis formation³¹	9.6	NOTCH3, NOTCH4

GO Terms for genes affiliated with Pseudobulbar Palsy

Sources:
¹⁸Gene Ontology
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Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	forebrain development	GO:0030900	9.8	EMX2, NOTCH3
2	Notch receptor processing	GO:0007220	9.6	NOTCH3, NOTCH4
3	Notch signaling pathway	GO:0007219	9.5	NOTCH3, NOTCH4
4	cell proliferation in forebrain	GO:0021846	9.5	EMX2, SIX3
5	negative regulation of neuron differentiation	GO:0045665	9.5	NOTCH3, SIX3
6	camera-type eye development	GO:0043010	9.2	RAB3GAP1, SIX3

Sources for Pseudobulbar Palsy

¹BitterDB

²CDC

³Cell Signaling Technology

⁴ClinicalTrials

⁵Clinvar

⁶Cochrane Library

⁷Cosmic

⁸dbSNP

⁹DGIdb

¹⁰Disease Ontology

¹¹diseasecard

¹²DISEASES

¹³DrugBank

¹⁴ExPASy

¹⁵FDA

¹⁶FMA

¹⁷Gene Expression Omnibus DataSets

¹⁸Gene Ontology

¹⁹GeneAnalytics

²⁰GeneCards

²¹GeneReviews

²²GeneTests

²³Genetics Home Reference

²⁴GTR

²⁵HGMD

²⁶HMDB

²⁷ICD10

²⁸ICD10 via Orphanet

²⁹ICD9CM

³⁰IUPHAR

³¹KEGG

³²LifeMap Discovery®

³³MalaCards

³⁴MedGen

³⁵MedlinePlus

³⁶MeSH

³⁷MESH via Orphanet

³⁸MGI

³⁹NCBI BioSystems Database

⁴⁰NCBI Bookshelf

⁴¹NCI

⁴²NCIt

⁴³NDF-RT

⁴⁴NIH Clinical Center

⁴⁵NIH Rare Diseases

⁴⁶NINDS

⁴⁷Novoseek

⁴⁸Novus Biologicals

⁴⁹OMIM

⁵⁰OMIM via Orphanet

⁵¹Orphanet

⁵²PathCards

⁵³PharmGKB

⁵⁴PubMed

⁵⁵QIAGEN

⁵⁶R&D Systems

⁵⁷Reactome

⁵⁸SinoBiological

⁵⁹SNOMED-CT

⁶⁰SNOMED-CT via Orphanet

⁶¹The Human Phenotype Ontology

⁶²Thomson Reuters

⁶³Tocris Bioscience

⁶⁴Tumor Gene Family of Databases

⁶⁵UMLS

⁶⁶UMLS via Orphanet

⁶⁷UniProtKB/Swiss-Prot

⁶⁸Wikipedia

MCID: PSD001 MIFTS: 35	Pseudobulbar Palsy malady Category: Neuronal diseases
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Pseudobulbar Palsy malady