MCID: PSD001
MIFTS: 28

Pseudobulbar Palsy malady

Neuronal diseases category

Aliases & Classifications for Pseudobulbar Palsy

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Aliases & Descriptions for Pseudobulbar Palsy:

Name: Pseudobulbar Palsy 10 12 65 36
 
Pseudobulbar Paralysis 10


Classifications:



External Ids:

Disease Ontology10 DOID:12680
ICD9CM29 335.23
SNOMED-CT59 7379000
MeSH36 D020828

Summaries for Pseudobulbar Palsy

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Wikipedia:68 Pseudobulbar palsy is a medical condition characterised by the inability to control facial movements... more...

MalaCards based summary: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to endocarditis and macrogyria, pseudobulbar palsy and mental retardation. An important gene associated with Pseudobulbar Palsy is NOTCH3 (Notch 3), and among its related pathways are Neural Crest Differentiation and Pre-NOTCH Expression and Processing. Affiliated tissues include tongue, brain and cerebellum, and related mouse phenotype nervous system.

Related Diseases for Pseudobulbar Palsy

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Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1endocarditis30.2SIX3, SRPX2
2macrogyria, pseudobulbar palsy and mental retardation10.5
3dementia10.4
4dystonia10.4
5lateral sclerosis10.3
6dysphagia10.3
7malaria10.2
8cerebrotendinous xanthomatosis10.2
9leukodystrophy, adult-onset, autosomal dominant10.2
10spastic paraplegia 9b, autosomal recessive10.2
11polymicrogyria, bilateral perisylvian10.2
12amyotrophic lateral sclerosis 110.2
13cerebritis10.2
14cerebral arteriopathy with subcortical infarcts and leukoencephalopathy10.1
15creutzfeldt-jakob disease10.1
16leukemia10.1
17motor neuron disease10.1
18antiphospholipid syndrome10.1
19neuronitis10.1
20progressive multifocal leukoencephalopathy10.1
21petroclival meningioma10.1
22encephalitis10.1
23ophthalmoplegia10.1
24speech disorder10.1
25trypanosomiasis10.1
26neuronal migration disorders10.1
27chorioretinitis10.1NOTCH3, NOTCH4
28trachea adenoid cystic carcinoma10.1NOTCH3, NOTCH4
29hajdu-cheney syndrome10.1NOTCH3, NOTCH4
30venous malformations, multiple cutaneous and mucosal10.0NOTCH3, NOTCH4
31bladder neck obstruction10.0NOTCH3, NOTCH4
32neurosarcoidosis10.0ARFGEF2, EMX2
33cerebral hemisphere lipoma10.0NOTCH3, NOTCH4
34schizencephaly9.9EMX2, SIX3
35physical urticaria9.9ARFGEF2, SIX3
36specific bursitis often of occupational origin9.9RAB3GAP1, SIX3
37congenital structural myopathy9.8ARFGEF2, SIX3
38pachyonychia congenita9.6ARFGEF2, EMX2, SIX3, SRPX2
39vestibular neuronitis9.0ARFGEF2, EMX2, NOTCH3, NOTCH4, RAB3GAP1, SIX3

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to pseudobulbar palsy

Symptoms for Pseudobulbar Palsy

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Drugs & Therapeutics for Pseudobulbar Palsy

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Pseudobulbar Palsy


Cochrane evidence based reviews: Pseudobulbar Palsy

Genetic Tests for Pseudobulbar Palsy

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Anatomical Context for Pseudobulbar Palsy

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MalaCards organs/tissues related to Pseudobulbar Palsy:

33
Tongue, Brain, Cerebellum, Trachea

Animal Models for Pseudobulbar Palsy or affiliated genes

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MGI Mouse Phenotypes related to Pseudobulbar Palsy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.2ARFGEF2, EMX2, NOTCH3, NOTCH4, RAB3GAP1, SIX3

Publications for Pseudobulbar Palsy

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Articles related to Pseudobulbar Palsy:

(show all 43)
idTitleAuthorsYear
1
Pseudobulbar palsy due to bilateral injuries of corticobulbar tracts in a stroke patient. (26202710)
2015
2
Consecutive Lacunar Strokes Mimicking Brainstem Symptoms in a Patient With Pseudobulbar Palsy. (26185957)
2015
3
Pseudobulbar palsy due to deep-brain stimulation of the thalamic ventral intermediate nuclei. (25839917)
2015
4
Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. (24963673)
2014
5
Neurocysticercosis presenting as pseudobulbar palsy. (24741260)
2014
6
Pure pseudobulbar palsy due to a capsular infarction. (22504270)
2012
7
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)
2011
8
Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. (18305298)
2008
9
Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. (17078444)
2006
10
Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. (16771181)
2006
11
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. (16314998)
2005
12
Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. (15172029)
2004
13
Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. (17167648)
2002
14
Left atrial myxoma presenting as pseudobulbar palsy. (12134197)
2002
15
Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. (11848316)
2001
16
Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. (10965170)
2000
17
Pseudobulbar palsy recovery following HSV encephalitis in AIDS. (10726949)
2000
18
Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. (10453580)
1999
19
Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. (9926359)
1998
20
Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. (9153602)
1997
21
Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. (7750810)
1994
22
Pseudobulbar palsy associated with trismus. (7824418)
1994
23
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. (2011096)
1991
24
Pseudobulbar palsy: a clinical computed tomography study. (2298226)
1990
25
Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. (2715610)
1989
26
Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (2738597)
1989
27
Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)
1989
28
Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. (3366147)
1988
29
Neoplastic obstruction of the trachea complicating pseudobulbar palsy. (3406789)
1988
30
Trismus in pseudobulbar palsy. (4093375)
1985
31
Pseudobulbar palsy after carotid endarterectomy. (4047367)
1985
32
Pseudobulbar palsy after posterior fossa operation in children. (6504288)
1984
33
Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. (7129273)
1982
34
Lithium carbonate in pseudobulbar palsy. (6782937)
1981
35
Dysphagia of pseudobulbar palsy successfully treated by hypnosis. (6929999)
1980
36
Control of emotional expression in pseudobulbar palsy. A personal experience. (911237)
1977
37
Pseudobulbar palsy. (5419589)
1970
38
Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)
1967
39
SUPRANUCLEAR (PSEUDOBULBAR) PALSY. (14332003)
1965
40
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)
1964
41
SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". (14272249)
1963
42
Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. (14777908)
1950
43
Facial seborrhoea in arteriosclerotic pseudobulbar palsy. (18933673)
1948

Variations for Pseudobulbar Palsy

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Expression for genes affiliated with Pseudobulbar Palsy

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Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for genes affiliated with Pseudobulbar Palsy

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Pathways related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6NOTCH3, NOTCH4
2
Show member pathways
9.6NOTCH3, NOTCH4
39.6NOTCH3, NOTCH4
4
Angiogenesis (CST)
Show member pathways
9.6NOTCH3, NOTCH4
5
Notch signaling pathway (Pathway Interaction Database)
Show member pathways
9.6NOTCH3, NOTCH4
69.6NOTCH3, NOTCH4

GO Terms for genes affiliated with Pseudobulbar Palsy

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Cellular components related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi membraneGO:00001399.1ARFGEF2, NOTCH3, NOTCH4

Biological processes related to Pseudobulbar Palsy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of developmental processGO:005079310.2NOTCH3, NOTCH4
2Notch receptor processingGO:000722010.1NOTCH3, NOTCH4
3negative regulation of cell differentiationGO:00455969.9NOTCH3, NOTCH4
4cell proliferation in forebrainGO:00218469.8EMX2, SIX3
5negative regulation of neuron differentiationGO:00456659.7NOTCH3, SIX3
6forebrain developmentGO:00309009.3EMX2, NOTCH3
7camera-type eye developmentGO:00430109.1RAB3GAP1, SIX3
8brain developmentGO:00074208.5EMX2, RAB3GAP1, SIX3

Sources for Pseudobulbar Palsy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet