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MCID: PSD001
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Pseudobulbar Palsy malady
10 genes, 4 tissues, 25 related diseases, clinical trials.

Summaries for Pseudobulbar Palsy

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64Wikipedia, 33MalaCards
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Wikipedia:64 Pseudobulbar palsy is a medical condition characterised by the inability to control facial movements... more...

MalaCards: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to macrogyria, pseudobulbar palsy and mental retardation and lateral sclerosis. An important gene associated with Pseudobulbar Palsy is EMX2 (empty spiracles homeobox 2), and among its related pathways are Dorso-ventral axis formation and NOTCH2 intracellular domain regulates transcription. Affiliated tissues include brain, cerebellum and tongue, and related mouse phenotype nervous system.

Aliases & Classifications for Pseudobulbar Palsy

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Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

pseudobulbar palsy 8 10 61
pseudobulbar paralysis 8


External Ids:

Disease Ontology8 DOID:12680
ICD9CM27 335.23
SNOMED-CT57 7379000
MeSH35 D020828

Related Diseases for Pseudobulbar Palsy

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17GeneCards, 18GeneDecks
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Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 25)
idRelated DiseaseScoreTop Affiliating Genes
1macrogyria, pseudobulbar palsy and mental retardation10.5
2lateral sclerosis10.3
3amyotrophic lateral sclerosis10.3
4dysphagia10.3
5cerebral malaria10.1
6antiphospholipid syndrome10.1
7petroclival meningioma10.1
8progressive supranuclear palsy10.1
9progressive multifocal leukoencephalopathy10.1
10speech disorder10.1
11trypanosomiasis10.1
12young syndrome10.1
13bilateral frontoparietal polymicrogyria10.1
14foix chavany marie syndrome10.1
15pseudobulbar affect10.1
16mental retardation epilepsy10.1
17mental retardation10.1
18central bilateral macrogyria10.1
19lissencephaly10.0GPR56, EMX2
20polymicrogyria10.0GPR56
21focal epilepsy10.0EMX2, GPR56
22stroke, ischemic10.0NOTCH4, NOTCH3
23cadasil10.0NOTCH4, NOTCH3
24microcephaly10.0RAB3GAP1, ARFGEF2
25periventricular nodular heterotopia10.0ARFGEF2, EMX2, GPR56

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to pseudobulbar palsy

Clinical Features for Pseudobulbar Palsy

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Drugs & Therapeutics for Pseudobulbar Palsy

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pseudobulbar Palsy

Search CenterWatch for Pseudobulbar Palsy

Genetic Tests for Pseudobulbar Palsy

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Anatomical Context for Pseudobulbar Palsy

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33MalaCards
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MalaCards organs/tissues related to Pseudobulbar Palsy:

33
Brain, Cerebellum, Tongue, Trachea

Animal Models for Pseudobulbar Palsy or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Pseudobulbar Palsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
nervous system phenotype
MP:00036317.1SPG20, NOTCH4, NOTCH3, RAB3GAP1, GPR56, EMX2

Publications for Pseudobulbar Palsy

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51PubMed
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Articles related to Pseudobulbar Palsy:

(show all 38)
idTitleAuthorsYear
1
Pure pseudobulbar palsy due to a capsular infarction. (22504270)
2012
2
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)
2011
3
Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. (18305298)
2008
4
Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. (17078444)
2006
5
Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. (16771181)
2006
6
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. (16314998)
2005
7
Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. (15172029)
2004
8
Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. (17167648)
2002
9
Left atrial myxoma presenting as pseudobulbar palsy. (12134197)
2002
10
Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. (11848316)
2001
11
Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. (10965170)
2000
12
Pseudobulbar palsy recovery following HSV encephalitis in AIDS. (10726949)
2000
13
Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. (10453580)
1999
14
Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. (9926359)
1998
15
Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. (9153602)
1997
16
Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. (7750810)
1994
17
Pseudobulbar palsy associated with trismus. (7824418)
1994
18
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. (2011096)
1991
19
Pseudobulbar palsy: a clinical computed tomography study. (2298226)
1990
20
Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. (2715610)
1989
21
Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (2738597)
1989
22
Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)
1989
23
Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. (3366147)
1988
24
Neoplastic obstruction of the trachea complicating pseudobulbar palsy. (3406789)
1988
25
Trismus in pseudobulbar palsy. (4093375)
1985
26
Pseudobulbar palsy after carotid endarterectomy. (4047367)
1985
27
Pseudobulbar palsy after posterior fossa operation in children. (6504288)
1984
28
Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. (7129273)
1982
29
Lithium carbonate in pseudobulbar palsy. (6782937)
1981
30
Dysphagia of pseudobulbar palsy successfully treated by hypnosis. (6929999)
1980
31
Control of emotional expression in pseudobulbar palsy. A personal experience. (911237)
1977
32
Pseudobulbar palsy. (5419589)
1970
33
Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)
1967
34
SUPRANUCLEAR (PSEUDOBULBAR) PALSY. (14332003)
1965
35
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)
1964
36
SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". (14272249)
1963
37
Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. (14777908)
1950
38
Facial seborrhoea in arteriosclerotic pseudobulbar palsy. (18933673)
1948

Genetic Variations for Pseudobulbar Palsy

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Expression for genes affiliated with Pseudobulbar Palsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pseudobulbar Palsy

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Pathways for genes affiliated with Pseudobulbar Palsy

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Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database
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Pathways related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Dorso-ventral axis formation30
9.7NOTCH4, NOTCH3
2
NOTCH2 intracellular domain regulates transcription54
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9.7NOTCH4, NOTCH3
3
Post-transcriptional Silencing By Small RNAs54
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9.7NOTCH4, NOTCH3
4
Signaling by NOTCH354
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9.7NOTCH4, NOTCH3
5
Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor54
9.7NOTCH4, NOTCH3
6
Notch signaling pathway38
9.7NOTCH4, NOTCH3
7
Pre-NOTCH Processing in Golgi54
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9.7NOTCH3, NOTCH4

Compounds for genes affiliated with Pseudobulbar Palsy

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GO Terms for genes affiliated with Pseudobulbar Palsy

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16Gene Ontology
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Biological processes related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch receptor processingGO:0072209.7NOTCH4, NOTCH3

Molecular functions related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.1SPG20, SRPX2, NOTCH4, NOTCH3, RAB3IL1, KIAA1279

Products for genes affiliated with Pseudobulbar Palsy

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Sources for Pseudobulbar Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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