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MCID: PSD001

Pseudobulbar Palsy malady
10 genes, 1 tissue, 8 related diseases, clinical trials.

Summaries for Pseudobulbar Palsy

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59Wikipedia, 29MalaCards
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Wikipedia:59 Pseudobulbar palsy is a medical condition characterised by the inability to control facial movements... more...

MalaCards: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to polymicrogyria and lissencephaly. An important gene associated with Pseudobulbar Palsy is EMX2 (empty spiracles homeobox 2), and among its related pathways are Pre-NOTCH Processing in Golgi and NOTCH2 Activation and Transmission of Signal to the Nucleus. Affiliated tissues include tongue and tongue, and related mouse phenotype nervous system.

Aliases & Classifications for Pseudobulbar Palsy

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Sources:
8Disease Ontology, 10DISEASES, 56UMLS, 25ICD9CM, 31MeSH, 52SNOMED-CT
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Aliases & Descriptions:

pseudobulbar palsy 8 10 56
pseudobulbar paralysis 8



External Ids:

Disease Ontology8 DOID:12680
ICD9CM25 335.23
SNOMED-CT52 7379000

Related Diseases for Pseudobulbar Palsy

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16GeneCards, 17GeneDecks
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Diseases related to pseudobulbar palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1polymicrogyria12.9GPR56
2lissencephaly12.7EMX2, GPR56
3focal epilepsy12.7EMX2, GPR56
4cerebrovascular accident12.6NOTCH4, NOTCH3
5cadasil12.3NOTCH4, NOTCH3
6periventricular nodular heterotopia12.3ARFGEF2, EMX2, GPR56
7microcephaly12.2RAB3GAP1, ARFGEF2
8macrogyria, pseudobulbar palsy and mental retardation8.7

Graphical network of diseases related to pseudobulbar palsy:



Diseases related to pseudobulbar palsy

Symptoms for Pseudobulbar Palsy

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Drugs & Therapeutics for Pseudobulbar Palsy

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Sources:
5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for pseudobulbar palsy

Drug clinical trials:

Search ClinicalTrials for pseudobulbar palsy

Search NIH Clinical Center for pseudobulbar palsy

Search CenterWatch for pseudobulbar palsy

Genetic Tests for Pseudobulbar Palsy

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Anatomical Context for Pseudobulbar Palsy

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29MalaCards
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MalaCards organs/tissues related to pseudobulbar palsy:

29
Tongue

Animal Models for Pseudobulbar Palsy or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to pseudobulbar palsy:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
nervous system phenotype
MP:00036317.1ARFGEF2, EMX2, NOTCH4, NOTCH3, GPR56, SPG20

Publications for Pseudobulbar Palsy

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Variations for Pseudobulbar Palsy

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Expression for genes affiliated with Pseudobulbar Palsy

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Pseudobulbar Palsy

Pathways for genes affiliated with Pseudobulbar Palsy

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Sources:
50Reactome, 27KEGG, 34NCBI BioSystems Database
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Pathways related to pseudobulbar palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Pre-NOTCH Processing in Golgi50
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9.7NOTCH4, NOTCH3
2
NOTCH2 Activation and Transmission of Signal to the Nucleus50
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9.7NOTCH4, NOTCH3
3
Signaling by NOTCH350
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9.7NOTCH4, NOTCH3
4
p53 positively regulates transcription of MIR34 microRNAs50
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9.7NOTCH4, NOTCH3
5
Dorso-ventral axis formation27
9.7NOTCH4, NOTCH3
6
Mature NOTCH heterodimer traffics to the plasma membrane50
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9.7NOTCH3, NOTCH4
7
Notch signaling pathway34
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8.9NOTCH4, NOTCH4, NOTCH3, NOTCH3

Compounds for genes affiliated with Pseudobulbar Palsy

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GO Terms for genes affiliated with Pseudobulbar Palsy

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Sources:
15Gene Ontology
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Biological processes related to pseudobulbar palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch receptor processingGO:0072209.7NOTCH4, NOTCH3

Molecular functions related to pseudobulbar palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.9ARFGEF2, EMX2, NOTCH4, NOTCH3, SRPX2, SPG20

Products for genes affiliated with Pseudobulbar Palsy

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  • Antibodies
  • Proteins
  • Lysates

Sources for Pseudobulbar Palsy

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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