MCID: PSD001
MIFTS: 29

Pseudobulbar Palsy malady

Neuronal diseases category
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Summaries for Pseudobulbar Palsy

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Pseudobulbar palsy is a medical condition characterised by the inability to control facial movements... more...

MalaCards: Pseudobulbar Palsy, also known as pseudobulbar paralysis, is related to macrogyria, pseudobulbar palsy and mental retardation and lateral sclerosis. An important gene associated with Pseudobulbar Palsy is SRPX2 (sushi-repeat containing protein, X-linked 2), and among its related pathways are Thyroid hormone signaling pathway and Signaling by NOTCH1 PEST Domain Mutants in Cancer. Affiliated tissues include tongue, brain and cerebellum.

Aliases & Classifications for Pseudobulbar Palsy

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8Disease Ontology, 10DISEASES, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

pseudobulbar palsy 8 10 62
pseudobulbar paralysis 8


External Ids:

Disease Ontology8 DOID:12680
ICD9CM27 335.23
SNOMED-CT58 7379000
MeSH35 D020828

Related Diseases for Pseudobulbar Palsy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pseudobulbar Palsy:



Diseases related to pseudobulbar palsy

Symptoms for Pseudobulbar Palsy

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Drugs & Therapeutics for Pseudobulbar Palsy

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Pseudobulbar Palsy

Genetic Tests for Pseudobulbar Palsy

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Anatomical Context for Pseudobulbar Palsy

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33MalaCards
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MalaCards organs/tissues related to Pseudobulbar Palsy:

33
Tongue, Brain, Cerebellum, Trachea

Animal Models for Pseudobulbar Palsy or affiliated genes

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Publications for Pseudobulbar Palsy

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52PubMed
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Articles related to Pseudobulbar Palsy:

(show all 37)
idTitleAuthorsYear
1
Pure pseudobulbar palsy due to a capsular infarction. (22504270)
2012
2
Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)
2011
3
Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. (18305298)
2008
4
Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. (17078444)
2006
5
Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. (16771181)
2006
6
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. (16314998)
2005
7
Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. (15172029)
2004
8
Left atrial myxoma presenting as pseudobulbar palsy. (12134197)
2002
9
Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. (11848316)
2001
10
Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. (10965170)
2000
11
Pseudobulbar palsy recovery following HSV encephalitis in AIDS. (10726949)
2000
12
Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. (10453580)
1999
13
Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. (9926359)
1998
14
Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. (9153602)
1997
15
Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. (7750810)
1994
16
Pseudobulbar palsy associated with trismus. (7824418)
1994
17
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. (2011096)
1991
18
Pseudobulbar palsy: a clinical computed tomography study. (2298226)
1990
19
Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. (2715610)
1989
20
Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (2738597)
1989
21
Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)
1989
22
Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. (3366147)
1988
23
Neoplastic obstruction of the trachea complicating pseudobulbar palsy. (3406789)
1988
24
Trismus in pseudobulbar palsy. (4093375)
1985
25
Pseudobulbar palsy after carotid endarterectomy. (4047367)
1985
26
Pseudobulbar palsy after posterior fossa operation in children. (6504288)
1984
27
Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. (7129273)
1982
28
Lithium carbonate in pseudobulbar palsy. (6782937)
1981
29
Dysphagia of pseudobulbar palsy successfully treated by hypnosis. (6929999)
1980
30
Control of emotional expression in pseudobulbar palsy. A personal experience. (911237)
1977
31
Pseudobulbar palsy. (5419589)
1970
32
Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)
1967
33
SUPRANUCLEAR (PSEUDOBULBAR) PALSY. (14332003)
1965
34
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)
1964
35
SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". (14272249)
1963
36
Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. (14777908)
1950
37
Facial seborrhoea in arteriosclerotic pseudobulbar palsy. (18933673)
1948

Variations for Pseudobulbar Palsy

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Expression for genes affiliated with Pseudobulbar Palsy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pseudobulbar Palsy

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Pathways for genes affiliated with Pseudobulbar Palsy

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Sources:
50PathCards, 30KEGG, 55Reactome, 5Cell Signaling Technology, 53QIAGEN, 38NCBI BioSystems Database, 54R&D Systems
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Pathways related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0NOTCH3, NOTCH4
2
Show member pathways
9.0NOTCH3, NOTCH4
39.0NOTCH4, NOTCH3
49.0NOTCH3, NOTCH4
59.0NOTCH3, NOTCH4
6
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
9.0NOTCH4, NOTCH3
79.0NOTCH3, NOTCH4
8
Show member pathways
9.0NOTCH3, NOTCH4
9
Show member pathways
Notch signaling pathway38
9.0NOTCH3, NOTCH4
109.0NOTCH4, NOTCH3
119.0NOTCH3, NOTCH4
129.0NOTCH3, NOTCH4

Compounds for genes affiliated with Pseudobulbar Palsy

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GO Terms for genes affiliated with Pseudobulbar Palsy

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16Gene Ontology
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Cellular components related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi membraneGO:0001398.5ARFGEF2, NOTCH3, NOTCH4

Biological processes related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:0063679.0NOTCH3, NOTCH4
2Notch receptor processingGO:0072208.9NOTCH3, NOTCH4
3Notch signaling pathwayGO:0072198.7NOTCH3, NOTCH4

Molecular functions related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.5ARFGEF2, NOTCH3, NOTCH4, KIAA1279, SRPX2

Products for genes affiliated with Pseudobulbar Palsy

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Sources for Pseudobulbar Palsy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet