Pseudobulbar Palsy disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Pseudobulbar Palsy

Sources:
⁶⁴Wikipedia, ³²MalaCards
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Looking for an antibody for researching pseudobulbar palsy?

SRPX2 antibody
KIAA1279 antibody
NOTCH4 antibody
NOTCH3 antibody
ARFGEF2 antibody

Wikipedia:⁶⁴ Pseudobulbar palsy is a medical condition characterised by the inability to control facial movements... more...

MalaCards based summary: Pseudobulbar Palsy, also known as paralysis, pseudobulbar, is related to macrogyria, pseudobulbar palsy and mental retardation and dementia. An important gene associated with Pseudobulbar Palsy is SRPX2 (sushi-repeat containing protein, X-linked 2), and among its related pathways are Thyroid hormone signaling pathway and Signaling by NOTCH1 PEST Domain Mutants in Cancer. Affiliated tissues include tongue, brain and cerebellum.

Aliases & Classifications for Pseudobulbar Palsy

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁶¹UMLS, ²⁸ICD9CM, ⁵⁶SNOMED-CT, ³⁴MeSH
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Pseudobulbar Palsy, Aliases & Descriptions:

Name: Pseudobulbar Palsy ⁹ ¹¹ ⁶¹

Paralysis, Pseudobulbar ⁶¹

Pseudobulbar Paralysis ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases

External Ids:

Disease Ontology⁹ DOID:12680

ICD9CM²⁸ 335.23

SNOMED-CT⁵⁶ 7379000

MeSH³⁴ D020828

UMLS⁶¹ C0033790

Related Diseases for Pseudobulbar Palsy

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
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Diseases related to Pseudobulbar Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 29)

id	Related Disease	Score	Top Affiliating Genes
1	macrogyria, pseudobulbar palsy and mental retardation	10.5
2	dementia	10.4
3	dystonia	10.4
4	amyotrophic lateral sclerosis	10.3
5	lateral sclerosis	10.3
6	progressive supranuclear palsy	10.3
7	dysphagia	10.3
8	malaria	10.2
9	cerebral malaria	10.2
10	cerebritis	10.2
11	leukemia	10.1
12	antiphospholipid syndrome	10.1
13	petroclival meningioma	10.1
14	progressive multifocal leukoencephalopathy	10.1
15	creutzfeldt-jakob disease	10.1
16	neuronitis	10.1
17	encephalitis	10.1
18	endocarditis	10.1
19	meningioma	10.1
20	ophthalmoplegia	10.1
21	speech disorder	10.1
22	trypanosomiasis	10.1
23	bilateral frontoparietal polymicrogyria	10.1
24	mental retardation	10.1
25	neuronal migration disorders	10.1
26	cadasil	9.8	NOTCH4, NOTCH3
27	migraine	9.8	NOTCH3, NOTCH4
28	vascular dementia	9.8	NOTCH3, NOTCH4
29	stroke, ischemic	9.7	NOTCH4, NOTCH3

Graphical network of the top 20 diseases related to Pseudobulbar Palsy:

Symptoms for Pseudobulbar Palsy

Drugs & Therapeutics for Pseudobulbar Palsy

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pseudobulbar Palsy

Search NIH Clinical Center for Pseudobulbar Palsy

Genetic Tests for Pseudobulbar Palsy

Anatomical Context for Pseudobulbar Palsy

Sources:
³²MalaCards
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MalaCards organs/tissues related to Pseudobulbar Palsy:

³²

Tongue, Brain, Cerebellum, Trachea

Animal Models for Pseudobulbar Palsy or affiliated genes

Publications for Pseudobulbar Palsy

Sources:
⁵¹PubMed
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Articles related to Pseudobulbar Palsy:

(show all 40)

id	Title	Authors	Year
1	Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, Basal Ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. (24963673)	Steele J.C.... Olszewski J.	2014
2	Neurocysticercosis presenting as pseudobulbar palsy. (24741260)	Kumar A.S.... Subrahmanyam D.K.	2014
3	Pure pseudobulbar palsy due to a capsular infarction. (22504270)	Maeda K.... Shiraishi T.	2012
4	Dental management of the tropical disease human African trypanosomiasis: an unusual case of pseudobulbar palsy. (21217721)	Frost L.	2011
5	Pseudobulbar palsy and affect in a case of progressive multifocal leukoencephalopathy. (18305298)	Graham K.C.... Spiegel D.R.	2008
6	Thirty-six cases of pseudobulbar palsy treated by needling with prompt and deep insertion. (17078444)	Hong C.	2006
7	Bilateral perisylvian ulegyria: clinicopathological study of patients presenting with pseudobulbar palsy and epilepsy. (16771181)	Kim H.I.... Kim S.U.	2006
8	Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin. (16314998)	Kinirons P.... Murphy R.P.	2005
9	Acute pseudobulbar palsy as the initial presentation of intravascular lymphomatosis. (15172029)	Arboix A.... Sans-Sabrafen J.	2004
10	Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases. (17167648)	McCormick W.E.... Lee J.H.	2002
11	Left atrial myxoma presenting as pseudobulbar palsy. (12134197)	Kumar A.... Malhotra H.S.	2002
12	Primary antiphospholipid syndrome presenting as pseudobulbar palsy in a young male. (11848316)	Aleem M.A.... Jayapal V.	2001
13	Creutzfeldt-Jakob disease presenting as isolated dysarthria and dysphagia due to pseudobulbar palsy. (10965170)	Frank H.G.... Landis T.	2000
14	Pseudobulbar palsy recovery following HSV encephalitis in AIDS. (10726949)	Kulasegaram R.... Rodgers C.A.	2000
15	Clinical observations on acupuncture treatment of pseudobulbar palsy--a report of 325 cases. (10453580)	Shi X.... Zhang H.	1999
16	Analysis of speech disorders in acute pseudobulbar palsy: a longitudinal study of a patient with lingual paralysis. (9926359)	Leroy-Malherbe V.... Arabia C.	1998
17	Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. (9153602)	Abrahams S.... Leigh P.N.	1997
18	Bilateral thalamic infarcts presenting as acute pseudobulbar palsy. (7750810)	Karacostas D.... Bogousslavsky J.	1994
19	Pseudobulbar palsy associated with trismus. (7824418)	Lai M.M.... Howard R.S.	1994
20	Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. (2011096)	Shaw P.J.... Stevens M.M.	1991
21	Pseudobulbar palsy: a clinical computed tomography study. (2298226)	Loeb C.... Del Sette M.	1990
22	Acute pseudobulbar palsy due to bilateral focal cortical damage: the opercular syndrome of Foix-Chavany-Marie. (2715610)	Grattan-Smith P.J.... Boldt D.W.	1989
23	Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? (2738597)	Asfora W.T.... Kjellberg R.N.	1989
24	Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)	Kuzniecky R.... Leppik I.	1989
25	Lacunae and cribriform cavities of the brain. Correlations with pseudobulbar palsy and parkinsonism. (3366147)	Mancardi G.L.... Loeb C.	1988
26	Neoplastic obstruction of the trachea complicating pseudobulbar palsy. (3406789)	Aumentado D.J.... Payne C.B.	1988
27	Trismus in pseudobulbar palsy. (4093375)	Dhamija R.M.... Maheshwari M.C.	1985
28	Pseudobulbar palsy after carotid endarterectomy. (4047367)	Solomon R.A.... Correll J.W.	1985
29	Pseudobulbar palsy after posterior fossa operation in children. (6504288)	Wisoff J.H.... Epstein F.J.	1984
30	Patterns of dysarthric movement in patients with amyotrophic lateral sclerosis and pseudobulbar palsy. (7129273)	Hirose H.... Sawashima M.	1982
31	Lithium carbonate in pseudobulbar palsy. (6782937)	Massey E.W.... Lowe S.	1981
32	Dysphagia of pseudobulbar palsy successfully treated by hypnosis. (6929999)	Black S.	1980
33	Control of emotional expression in pseudobulbar palsy. A personal experience. (911237)	Lieberman A.... Benson D.F.	1977
34	Pseudobulbar palsy. (5419589)	Flora G.C.	1970
35	Bacterial endocarditis presenting as pseudobulbar palsy. (6053619)	SHAFAR J.	1967
36	SUPRANUCLEAR (PSEUDOBULBAR) PALSY. (14332003)	ARING C.D.	1965
37	PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)	Steele J.C.... Olszewski J.	1964
38	SUPRANUCLEAR OPHTHALMOPLEGIA, PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. A CLINICAL REPORT ON EIGHT CASES OF "HETEROGENOUS SYSTEM DEGENERATION". (14272249)	Richardson J.C.... Olszewski J.	1963
39	Supranuclear bulbar palsy (pseudobulbar palsy) in mitral stenosis. (14777908)	HEATHFIELD K.W.... JEWESBURY E.C.	1950
40	Facial seborrhoea in arteriosclerotic pseudobulbar palsy. (18933673)	ELLIOTT F.A.	1948

Genes related to Pseudobulbar Palsy

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
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Genes related to Pseudobulbar Palsy:

- Elite gene

id	Symbol	Description	Score	Implication
1	SRPX2	sushi-repeat containing protein, X-linked 2	22.05	GeneCards inferred via : Disorders (show sections)
2	KIAA1279	KIAA1279	18.05	GeneCards inferred via : Disorders (show sections)
3	NOTCH4	notch 4	14.05	GeneCards inferred via : Disorders (show sections)
4	NOTCH3	notch 3	10.05	GeneCards inferred via : Disorders (show sections)
5	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	6.05	GeneCards inferred via : Disorders (show sections)

Products for genes related to Pseudobulbar Palsy disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	4	-	5	5
2	Novus Biologicals	3	3	5	-

Variations for Pseudobulbar Palsy

Expression for genes affiliated with Pseudobulbar Palsy

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²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pseudobulbar Palsy

Search GEO for disease gene expression data for Pseudobulbar Palsy.

Pathways for genes affiliated with Pseudobulbar Palsy

Sources:
⁴⁹PathCards, ³⁰KEGG, ⁵⁴Reactome, ⁵Cell Signaling Technology, ⁵²QIAGEN, ³⁷NCBI BioSystems Database, ⁵³R&D Systems
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Pathways related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

(show all 12)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Thyroid hormone signaling pathway³⁰	9.0	NOTCH3, NOTCH4
2	Signaling by NOTCH1 PEST Domain Mutants in Cancer⁵⁴ Show member pathways Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants⁵⁴ Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant⁵⁴ Constitutive Signaling by NOTCH1 PEST Domain Mutants⁵⁴ FBXW7 Mutants and NOTCH1 in Cancer⁵⁴ Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer⁵⁴ NOTCH1 Intracellular Domain Regulates Transcription⁵⁴ Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling⁵⁴ Signaling by NOTCH1 HD Domain Mutants in Cancer⁵⁴ Signaling by NOTCH1 in Cancer⁵⁴ Signaling by NOTCH⁵⁴ Signaling by NOTCH1⁵⁴	9.0	NOTCH3, NOTCH4
3	Wnt / Hedgehog / Notch⁵	9.0	NOTCH4, NOTCH3
4	Presenilin-Mediated Signaling⁵²	9.0	NOTCH3, NOTCH4
5	Neuroscience⁵	9.0	NOTCH3, NOTCH4
6	Notch signaling pathway³⁰ Show member pathways Signaling by NOTCH3⁵⁴ Delta-Notch Signaling Pathway³⁷ Notch Signaling⁵² Signaling by NOTCH4⁵⁴ Notch Signaling Pathway³⁷	9.0	NOTCH4, NOTCH3
7	Neural Crest Differentiation³⁷	9.0	NOTCH3, NOTCH4
8	Pre-NOTCH Expression and Processing⁵⁴ Show member pathways Pre-NOTCH Processing in Golgi⁵⁴ Pre-NOTCH Processing in the Endoplasmic Reticulum⁵⁴ Notch-HLH transcription pathway⁵⁴ Pre-NOTCH Transcription and Translation⁵⁴	9.0	NOTCH3, NOTCH4
9	Notch signaling pathway³⁰ Show member pathways Notch signaling pathway³⁷	9.0	NOTCH3, NOTCH4
10	Angiogenesis⁵	9.0	NOTCH4, NOTCH3
11	Notch Signaling Pathways⁵³	9.0	NOTCH3, NOTCH4
12	Dorso-ventral axis formation³⁰	9.0	NOTCH3, NOTCH4

Compounds for genes affiliated with Pseudobulbar Palsy

GO Terms for genes affiliated with Pseudobulbar Palsy

Sources:
¹⁷Gene Ontology
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Cellular components related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi membrane	GO:000139	8.5	ARFGEF2, NOTCH3, NOTCH4

Biological processes related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transcription initiation from RNA polymerase II promoter	GO:006367	9.0	NOTCH3, NOTCH4
2	Notch receptor processing	GO:007220	8.9	NOTCH3, NOTCH4
3	Notch signaling pathway	GO:007219	8.7	NOTCH3, NOTCH4

Molecular functions related to Pseudobulbar Palsy according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	7.5	ARFGEF2, NOTCH3, NOTCH4, KIAA1279, SRPX2

Products for genes affiliated with Pseudobulbar Palsy

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Sources for Pseudobulbar Palsy

¹antibodies-online

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⁴CDC

⁵Cell Signaling Technology

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⁸dbSNP

⁹Disease Ontology

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¹⁶Gene Expression Omnibus DataSets

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²²Genetics Home Reference

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³⁷NCBI BioSystems Database

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⁴¹NIH Clinical Center

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⁵¹PubMed

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⁵³R&D Systems

⁵⁴Reactome

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⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: PSD001 MIFTS: 30	Pseudobulbar Palsy malady Neuronal diseases category
5 genes, 4 tissues, 29 related diseases, clinical trials Download this MalaCard Expand all tables

Pseudobulbar Palsy malady