MCID: PSD010
MIFTS: 46

Pseudogout malady

Bone diseases category
Download this MalaCard

Summaries for Pseudogout

About this section


Fully expand this MalaCard
Wikipedia:65 Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as chondrocalcinosis,... more...

MalaCards based summary: Pseudogout, also known as calcium pyrophosphate deposition disease, is related to gout and arthritis. An important gene associated with Pseudogout is ANKH (ANKH inorganic pyrophosphate transport regulator), and among its related pathways is Glucuronidation. The compounds leflunomide and etanercept have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and liver.

Disease Ontology:8 An arthritis that has material basis in the accumulation of salt crystals located in joint.

Aliases & Classifications for Pseudogout

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
See all sources

Pseudogout, Aliases & Descriptions:

Name: Pseudogout 8 10 44 62
Calcium Pyrophosphate Deposition Disease 8 62
 
Chondrocalcinosis 8 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:1156
MeSH34 D002805
NCIt39 C34955

Related Diseases for Pseudogout

About this section

Diseases related to Pseudogout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.2BCKDHA, XDH
2arthritis30.9MMP1, ANKH, IL1RAPL2
3arthropathy30.8MMP1, ANKH, IL1RAPL2
4calcinosis30.4ENPP1, ANKH
5osteoarthritis29.6XDH, MMP1, ANKH, IL1RAPL2, ENPP1
6septic arthritis10.4
7cervicitis10.4
8hyperparathyroidism10.4
9ankylosis10.3ENPP1
10chondrocalcinosis 110.3
11polymyalgia rheumatica10.3
12carpal tunnel syndrome10.3
13gitelman syndrome10.3
14chondrocalcinosis due to apatite crystal deposition10.2
15rheumatoid arthritis10.2
16spinal stenosis10.2
17primary hyperparathyroidism10.2
18psoriatic arthritis10.2MMP1, IL1RAPL2
19ankylosing spondylitis10.2IL1RAPL2, ANKH
20craniosynostosis10.1ANKH, ENPP1
21periodontitis10.1IL1RAPL2, MMP1
22diffuse idiopathic skeletal hyperostosis10.1
23hyperostosis10.1
24hyperphosphatemic familial tumoral calcinosis10.1
25idiopathic pulmonary fibrosis10.1IL1RAPL2, MMP1
26acromegaly10.1
27synovitis10.1
28tuberculosis10.1
29chondrocalcinosis 210.1
30synovial chondromatosis10.1
31sepsis10.1
32periodontal disease10.1IL1RAPL2, MMP1
33hyperuricemia10.0BCKDHA, XDH
34hypophosphatasia10.0
35osteopoikilosis10.0
36hypercalcemia10.0
37hypokalemia10.0
38brachydactyly10.0
39craniometaphyseal dysplasia10.0
40short bowel syndrome10.0
41familial hypocalciuric hypercalcemia10.0
42normophosphatemic familial tumoral calcinosis10.0
43hypocalciuric hypercalcemia, type i10.0
44end stage renal failure9.9
45multiple myeloma9.9
46neutropenia9.9
47osteoporosis9.9
48primary biliary cirrhosis9.9
49systemic lupus erythematosus9.9
50ochronosis9.9

Graphical network of the top 20 diseases related to Pseudogout:



Diseases related to pseudogout

Symptoms for Pseudogout

About this section

Drugs & Therapeutics for Pseudogout

About this section

Drug clinical trials:

Search ClinicalTrials for Pseudogout

Search NIH Clinical Center for Pseudogout

Genetic Tests for Pseudogout

About this section

Anatomical Context for Pseudogout

About this section

MalaCards organs/tissues related to Pseudogout:

32
Bone, Liver, Neutrophil, Thyroid, Testes

FMA organs/tissues related to Pseudogout:

14
Joint

Animal Models for Pseudogout or affiliated genes

About this section

Publications for Pseudogout

About this section

Articles related to Pseudogout:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Huge tophaceous pseudogout associated with tenosynovial chondromatosis arising from flexor digitorum tendon sheaths of the foot: a case report. (23828620)
2013
2
Pseudogout. Crystals and joint pain. (24716277)
2013
3
Pathology quiz case 2. Tophaceous pseudogout (calcium pyrophosphate deposition disease [CPDD]) of the TMJ. (22986729)
2012
4
Cauda equina syndrome caused by pseudogout involving the lumbar intervertebral disc. (23255864)
2012
5
Recurrent parotid pseudogout. (23033502)
2012
6
The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis). (22303529)
2011
7
Mimicry in older patients: tophaceous pseudogout as a tumorlike lesion: a case report. (21957280)
2011
8
By the way, doctor. I've been diagnosed with pseudogout, which I understand is caused by a buildup of calcium crystals in the joints. Should I be concerned about taking a calcium supplement? (19777676)
2009
9
Weekly alendronate-induced acute pseudogout. (15611307)
2005
10
Temporomandibular joint pseudogout: an uncommon site for a familiar condition. (15547106)
2004
11
Questions & answers. What's the difference between gout and pseudogout? (14679973)
2003
12
Tumoral pseudogout of the metatarsal. (11807592)
2002
13
Evaluation of crystals in formalin-fixed, paraffin-embedded tissue sections for the differential diagnosis of pseudogout, gout, and tumoral calcinosis. (11504841)
2001
14
Possible causes of acute pseudogout in older patients with osteoarthritis. (10991746)
2000
15
Tophaceous pseudogout of the mitral valve. (9768968)
1998
16
Prospective use of intramuscular triamcinolone acetonide in pseudogout. (9195527)
1997
17
Cervical spine pseudogout with myelopathy and Charcot joints. (8856629)
1996
18
Coexistence of pseudogout and arthritis due to Actinobacillus actinomycetemcomitans. (8879809)
1996
19
Bilateral pseudogout of the temporomandibular joint: report of case and review of literature. (7776053)
1995
20
Pseudogout mimicking meningitis. (8461939)
1993
21
Lumbar spinal stenosis secondary to calcium pyrophosphate crystal deposition (pseudogout). (8472402)
1993
22
Gout and pseudogout in hospitalized patients. (8257255)
1993
23
Acute carpal tunnel syndrome due to pseudogout. (8345281)
1993
24
Gout and pseudogout. (8310084)
1993
25
A case of pseudo pseudogout. (1735756)
1992
26
Pseudogout associated with primary hyperparathyroidism: management in the immediate postoperative period for prevention of acute pseudogout attack. (3215148)
1988
27
Pseudoseptic pseudogout in progressive pseudorheumatoid arthritis of childhood. (3675014)
1987
28
Pseudogout following parathyroidectomy. (3437115)
1987
29
Pseudogout in a patient on renal dialysis. (3456088)
1986
30
Septic arthritis and pseudogout. (4087257)
1985
31
Histologic differentiation of gout and pseudogout using polarized light. (6546859)
1984
32
Acute pseudogout after oral glucose tolerance test. (6663588)
1983
33
Gout and pseudogout precipitated by parathyroidectomy. (7112087)
1982
34
The destructive wrist arthropathy of pseudogout. (7071623)
1982
35
Gout, pseudogout and rheumatoid arthritis in an elderly patient. (7123105)
1982
36
Colchicine and pseudogout. (7150388)
1982
37
Narrowing of knee joint space in patients with pseudogout. (7469524)
1981
38
Clinical and roentgenographic aspects of pseudogout: a study of 50 cases and a review. (7008926)
1981
39
Acute pseudogout: "crystal shedding" or acute crystallization? (6266426)
1981
40
Acute pseudogout simulating septic arthritis. (480605)
1979
41
Elevated inorganic pyrophosphate concentrations in synovial fluids in osteoarthritis and pseudogout. (4361744)
1974
42
Chondrocalcinosis articularis (pseudogout syndrome). (4541464)
1973
43
Pseudogout. (4354552)
1972-1973
44
Erythrocyte neutral inorganic pyrophosphatase in pseudogout. (5009714)
1972
45
Pseudogout. (5541153)
1971
46
Alkaline phosphatase in pseudogout. (4185629)
1969
47
Basal urinary pyrophosphate excretion in pseudogout. (4306837)
1969
48
Chondrocalcinosis (pseudogout). (5937364)
1966
49
Pseudogout vs. gout. (5946796)
1966
50
PSEUDOGOUT. (14338826)
1965

Variations for Pseudogout

About this section

Expression for genes affiliated with Pseudogout

About this section
Expression patterns in normal tissues for genes affiliated with Pseudogout

Search GEO for disease gene expression data for Pseudogout.

Pathways for genes affiliated with Pseudogout

About this section

Pathways related to Pseudogout according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3ENPP1, XDH

Compounds for genes affiliated with Pseudogout

About this section

Compounds related to Pseudogout according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1leflunomide44 50 1111.9MMP1, IL1RAPL2
2etanercept44 50 1111.9IL1RAPL2, MMP1
3infliximab44 50 1111.9MMP1, IL1RAPL2
4hydroxyapatite449.9ENPP1, ANKH
5ribavirin44 50 1111.9MMP1, ENPP1
6pentoxifylline44 1110.9IL1RAPL2, MMP1
7trolox449.8MMP1, XDH
8ethidium bromide449.8MMP1, XDH
9glycosaminoglycan449.8IL1RAPL2, MMP1
10pdtc449.7MMP1, XDH
11losartan44 50 28 1112.7MMP1, XDH
12prednisolone44 28 1111.7MMP1, IL1RAPL2
13rotenone449.7XDH, IL1RAPL2
144-hydroxynonenal44 2410.7MMP1, XDH
15salicylic acid44 2810.6XDH, IL1RAPL2
16rosiglitazone28 44 50 24 1113.6IL1RAPL2, MMP1
17sulfate44 2410.5IL1RAPL2, ENPP1
18cytochalasin d44 6110.4MMP1, IL1RAPL2
19egcg449.4XDH, MMP1
20spermine28 44 24 1112.4PPA1, XDH
21lactate449.3MMP1, XDH, IL1RAPL2
22dexamethasone44 50 28 1112.2ENPP1, MMP1, IL1RAPL2
23pyrophosphate44 2410.1ANKH, PPA1, ENPP1
2412-o-tetradecanoylphorbol 13-acetate449.1PPA1, MMP1, IL1RAPL2
25cyclosporin a44 28 6111.1MMP1, PPA1, IL1RAPL2
26alpha tocopherol449.0XDH, MMP1, PPA1
27ascorbic acid44 2410.0XDH, PPA1, MMP1
28superoxide44 249.9PPA1, XDH, IL1RAPL2
29Water248.7XDH, ENPP1, PPA1
30nitric oxide44 24 1110.5IL1RAPL2, XDH, PPA1
31h2o2448.5MMP1, IL1RAPL2, PPA1, XDH
32serine448.5IL1RAPL2, MMP1, PPA1, ENPP1
33threonine448.3PPA1, ENPP1, IL1RAPL2
34calcium44 50 24 1111.2MMP1, PPA1, ENPP1, IL1RAPL2, ANKH

GO Terms for genes affiliated with Pseudogout

About this section

Biological processes related to Pseudogout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inorganic diphosphate transportGO:0305059.5ENPP1, ANKH
2regulation of bone mineralizationGO:0305009.3ENPP1, ANKH
3phosphate-containing compound metabolic processGO:0067969.1ENPP1, PPA1

Products for genes affiliated with Pseudogout

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Pseudogout

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet