MCID: PSD010
MIFTS: 45

Pseudogout malady

Bone diseases category

Summaries for Pseudogout

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as chondrocalcinosis,... more...

MalaCards: Pseudogout, also known as calcium pyrophosphate deposition disease, is related to gout and arthritis. An important gene associated with Pseudogout is ANKH (ANKH inorganic pyrophosphate transport regulator), and among its related pathways is Glucuronidation. The compounds leflunomide and etanercept have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and liver.

Disease Ontology:9 An arthritis that has material basis in the accumulation of salt crystals located in joint.

Aliases & Classifications for Pseudogout

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

pseudogout 9 11 46 63
calcium pyrophosphate deposition disease 9 63
chondrocalcinosis 9 46


External Ids:

Disease Ontology9 DOID:1156
NCIt41 C34955
MeSH36 D002805

Related Diseases for Pseudogout

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Pseudogout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.1BCKDHA, XDH
2arthritis30.9IL1RAPL2, MMP1, ANKH
3arthropathy30.7ANKH, IL1RAPL2, MMP1
4calcinosis30.2ANKH, ENPP1
5osteoarthritis30.1ANKH, ENPP1, MMP1, XDH, IL1RAPL2
6septic arthritis10.4
7cervicitis10.4
8hyperparathyroidism10.4
9chondrocalcinosis 110.3
10polymyalgia rheumatica10.3
11carpal tunnel syndrome10.3
12gitelman syndrome10.3
13chondrocalcinosis due to apatite crystal deposition10.2
14spinal stenosis10.2
15primary hyperparathyroidism10.2
16rheumatoid arthritis10.2
17diffuse idiopathic skeletal hyperostosis10.1
18hyperostosis10.1
19hyperphosphatemic familial tumoral calcinosis10.1
20acromegaly10.1
21tuberculosis10.1
22chondrocalcinosis 210.1
23synovial chondromatosis10.1
24sepsis10.1
25ankylosis10.1ENPP1
26psoriatic arthritis10.0MMP1, IL1RAPL2
27ankylosing spondylitis10.0ANKH, IL1RAPL2
28craniosynostosis10.0ENPP1, ANKH
29periodontitis10.0IL1RAPL2, MMP1
30idiopathic pulmonary fibrosis10.0MMP1, IL1RAPL2
31periodontal disease10.0MMP1, IL1RAPL2
32hyperuricemia10.0BCKDHA, XDH
33endometriosis10.0XDH, MMP1
34pulmonary disease, chronic obstructive10.0MMP1, XDH
35septic shock10.0XDH, IL1RAPL2
36inflammatory bowel disease10.0XDH, IL1RAPL2, MMP1
37short bowel syndrome10.0
38osteopoikilosis10.0
39hypercalcemia10.0
40hypokalemia10.0
41brachydactyly10.0
42hypophosphatasia10.0
43craniometaphyseal dysplasia10.0
44familial hypocalciuric hypercalcemia10.0
45normophosphatemic familial tumoral calcinosis10.0
46hypocalciuric hypercalcemia, type i10.0
47giant cell reparative granuloma9.9
48discitis9.9
49paget's disease of bone9.9
50end stage renal failure9.9

Graphical network of the top 20 diseases related to Pseudogout:



Diseases related to pseudogout

Symptoms for Pseudogout

About this section

Drugs & Therapeutics for Pseudogout

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pseudogout

Drug clinical trials:

Search ClinicalTrials for Pseudogout

Search NIH Clinical Center for Pseudogout

Search CenterWatch for Pseudogout

Genetic Tests for Pseudogout

About this section

Anatomical Context for Pseudogout

About this section
Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Pseudogout:

34
Bone, Liver, Testes, Thyroid

FMA organs/tissues related to Pseudogout:

15
Joint

Animal Models for Pseudogout or affiliated genes

About this section

Publications for Pseudogout

About this section
Sources:
53PubMed
See all sources

Articles related to Pseudogout:

(show top 50)    (show all 287)
idTitleAuthorsYear
1
Huge tophaceous pseudogout associated with tenosynovial chondromatosis arising from flexor digitorum tendon sheaths of the foot: a case report. (23828620)
2013
2
Pathology quiz case 2. Tophaceous pseudogout (calcium pyrophosphate deposition disease [CPDD]) of the TMJ. (22986729)
2012
3
Cauda equina syndrome caused by pseudogout involving the lumbar intervertebral disc. (23255864)
2012
4
Recurrent parotid pseudogout. (23033502)
2012
5
The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis). (22303529)
2011
6
Mimicry in older patients: tophaceous pseudogout as a tumorlike lesion: a case report. (21957280)
2011
7
By the way, doctor. I've been diagnosed with pseudogout, which I understand is caused by a buildup of calcium crystals in the joints. Should I be concerned about taking a calcium supplement? (19777676)
2009
8
Weekly alendronate-induced acute pseudogout. (15611307)
2005
9
Temporomandibular joint pseudogout: an uncommon site for a familiar condition. (15547106)
2004
10
Questions & answers. What's the difference between gout and pseudogout? (14679973)
2003
11
Tumoral pseudogout of the metatarsal. (11807592)
2002
12
Evaluation of crystals in formalin-fixed, paraffin-embedded tissue sections for the differential diagnosis of pseudogout, gout, and tumoral calcinosis. (11504841)
2001
13
Possible causes of acute pseudogout in older patients with osteoarthritis. (10991746)
2000
14
Tophaceous pseudogout of the mitral valve. (9768968)
1998
15
Prospective use of intramuscular triamcinolone acetonide in pseudogout. (9195527)
1997
16
Cervical spine pseudogout with myelopathy and Charcot joints. (8856629)
1996
17
Coexistence of pseudogout and arthritis due to Actinobacillus actinomycetemcomitans. (8879809)
1996
18
Bilateral pseudogout of the temporomandibular joint: report of case and review of literature. (7776053)
1995
19
Pseudogout mimicking meningitis. (8461939)
1993
20
Lumbar spinal stenosis secondary to calcium pyrophosphate crystal deposition (pseudogout). (8472402)
1993
21
Gout and pseudogout in hospitalized patients. (8257255)
1993
22
Acute carpal tunnel syndrome due to pseudogout. (8345281)
1993
23
Gout and pseudogout. (8310084)
1993
24
A case of pseudo pseudogout. (1735756)
1992
25
Pseudogout of the ankle: a case study and arthroscopic-assisted treatment. (1865072)
1991
26
Pseudogout associated with primary hyperparathyroidism: management in the immediate postoperative period for prevention of acute pseudogout attack. (3215148)
1988
27
Pseudoseptic pseudogout in progressive pseudorheumatoid arthritis of childhood. (3675014)
1987
28
Pseudogout following parathyroidectomy. (3437115)
1987
29
Pseudogout in a patient on renal dialysis. (3456088)
1986
30
Septic arthritis and pseudogout. (4087257)
1985
31
Histologic differentiation of gout and pseudogout using polarized light. (6546859)
1984
32
Acute pseudogout after oral glucose tolerance test. (6663588)
1983
33
Gout and pseudogout precipitated by parathyroidectomy. (7112087)
1982
34
The destructive wrist arthropathy of pseudogout. (7071623)
1982
35
Gout, pseudogout and rheumatoid arthritis in an elderly patient. (7123105)
1982
36
Colchicine and pseudogout. (7150388)
1982
37
Narrowing of knee joint space in patients with pseudogout. (7469524)
1981
38
Clinical and roentgenographic aspects of pseudogout: a study of 50 cases and a review. (7008926)
1981
39
Acute pseudogout: "crystal shedding" or acute crystallization? (6266426)
1981
40
Acute pseudogout simulating septic arthritis. (480605)
1979
41
Elevated inorganic pyrophosphate concentrations in synovial fluids in osteoarthritis and pseudogout. (4361744)
1974
42
Chondrocalcinosis articularis (pseudogout syndrome). (4541464)
1973
43
Pseudogout. (4354552)
1972-1973
44
Erythrocyte neutral inorganic pyrophosphatase in pseudogout. (5009714)
1972
45
Pseudogout. (5541153)
1971
46
Alkaline phosphatase in pseudogout. (4185629)
1969
47
Basal urinary pyrophosphate excretion in pseudogout. (4306837)
1969
48
Chondrocalcinosis (pseudogout). (5937364)
1966
49
Pseudogout vs. gout. (5946796)
1966
50
PSEUDOGOUT. (14338826)
1965

Variations for Pseudogout

About this section

Expression for genes affiliated with Pseudogout

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pseudogout

Search GEO for disease gene expression data for Pseudogout.

Pathways for genes affiliated with Pseudogout

About this section
Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters
See all sources

Pathways related to Pseudogout according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3ENPP1, XDH

Compounds for genes affiliated with Pseudogout

About this section
Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
See all sources

Compounds related to Pseudogout according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1leflunomide46 52 1211.9MMP1, IL1RAPL2
2etanercept46 52 1211.9IL1RAPL2, MMP1
3infliximab46 52 1211.9MMP1, IL1RAPL2
4hydroxyapatite469.9ENPP1, ANKH
5ribavirin46 52 1211.9MMP1, ENPP1
6pentoxifylline46 1210.9IL1RAPL2, MMP1
7trolox469.8MMP1, XDH
8ethidium bromide469.8MMP1, XDH
9glycosaminoglycan469.8IL1RAPL2, MMP1
10pdtc469.7MMP1, XDH
11losartan46 52 30 1212.7MMP1, XDH
12prednisolone46 30 1211.7MMP1, IL1RAPL2
13rotenone469.7XDH, IL1RAPL2
144-hydroxynonenal46 2510.7MMP1, XDH
15salicylic acid46 3010.6XDH, IL1RAPL2
16rosiglitazone30 46 52 25 1213.6IL1RAPL2, MMP1
17sulfate46 2510.5IL1RAPL2, ENPP1
18cytochalasin d46 6210.4MMP1, IL1RAPL2
19egcg469.4XDH, MMP1
20spermine30 46 25 1212.4PPA1, XDH
21lactate469.3MMP1, XDH, IL1RAPL2
22dexamethasone46 52 30 1212.2ENPP1, MMP1, IL1RAPL2
23pyrophosphate46 2510.1ANKH, PPA1, ENPP1
2412-o-tetradecanoylphorbol 13-acetate469.1PPA1, MMP1, IL1RAPL2
25cyclosporin a46 30 6211.1MMP1, PPA1, IL1RAPL2
26alpha tocopherol469.0XDH, MMP1, PPA1
27ascorbic acid46 2510.0XDH, PPA1, MMP1
28superoxide46 259.9PPA1, XDH, IL1RAPL2
29Water258.7XDH, ENPP1, PPA1
30nitric oxide46 25 1210.5IL1RAPL2, XDH, PPA1
31h2o2468.5MMP1, IL1RAPL2, PPA1, XDH
32serine468.5IL1RAPL2, MMP1, PPA1, ENPP1
33threonine468.3PPA1, ENPP1, IL1RAPL2
34calcium46 52 25 1211.2MMP1, PPA1, ENPP1, IL1RAPL2, ANKH

GO Terms for genes affiliated with Pseudogout

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Pseudogout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inorganic diphosphate transportGO:0305059.5ENPP1, ANKH
2regulation of bone mineralizationGO:0305009.3ENPP1, ANKH
3phosphate-containing compound metabolic processGO:0067969.1ENPP1, PPA1

Products for genes affiliated with Pseudogout

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pseudogout

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet