MCID: PSD010
MIFTS: 42

Pseudogout malady

Summaries for Pseudogout

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as chondrocalcinosis,... more...

MalaCards: Pseudogout, also known as calcium pyrophosphate deposition disease, is related to gout and arthritis. An important gene associated with Pseudogout is ANKH (ANKH inorganic pyrophosphate transport regulator). The compounds alpha tocopherol and trolox have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and liver.

Disease Ontology:8 An arthritis that has material basis in the accumulation of salt crystals located in joint.

Aliases & Classifications for Pseudogout

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

pseudogout 8 10 44 60
calcium pyrophosphate deposition disease 8 60
chondrocalcinosis 8 44


External Ids:

Disease Ontology8 DOID:1156
MeSH34 D002805
NCIt39 C34955

Related Diseases for Pseudogout

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pseudogout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.0BCKDHA, XDH
2arthritis30.8ANKH, IL1RAPL2, MMP1
3arthropathy30.6ANKH, IL1RAPL2, MMP1
4osteoarthritis30.3ANKH, XDH, IL1RAPL2, MMP1, ENPP1
5synovitis30.0MMP1
6tuberculosis30.0IL1RAPL2
7calcinosis30.0ANKH, ENPP1
8hypophosphatasia29.8ENPP1
9septic arthritis10.4
10cervicitis10.3
11hyperparathyroidism10.3
12polymyalgia rheumatica10.3
13chondrocalcinosis 110.3
14carpal tunnel syndrome10.2
15gitelman syndrome10.2
16familial articular chondrocalcinosis type 110.2
17chondrocalcinosis due to apatite crystal deposition10.1
18familial articular chondrocalcinosis type 210.1
19primary hyperparathyroidism10.1
20spinal stenosis10.1
21rheumatoid arthritis10.1
22diffuse idiopathic skeletal hyperostosis10.1
23hyperostosis10.1
24hyperphosphatemic familial tumoral calcinosis10.1
25acromegaly10.0
26primary hyperoxaluria10.0SLC12A3
27sjogren's syndrome10.0IL1RAPL2
28dilated cardiomyopathy10.0MMP1
29hepatitis c10.0IL1RAPL2
30acute myocardial infarction10.0XDH
31ankylosis10.0ENPP1
32psoriatic arthritis10.0IL1RAPL2, MMP1
33ankylosing spondylitis10.0ANKH, IL1RAPL2
34diabetes mellitus10.0ENPP1
35periodontitis10.0MMP1, IL1RAPL2
36malaria10.0XDH
37obesity10.0ENPP1
38hepatitis10.0IL1RAPL2, XDH
39idiopathic pulmonary fibrosis10.0MMP1, IL1RAPL2
40hyperuricemia10.0BCKDHA, XDH
41pneumonia10.0IL1RAPL2, XDH
42periodontal disease10.0MMP1, IL1RAPL2
43coronary heart disease10.0XDH
44myocardial infarction10.0ENPP1, IL1RAPL2
45inflammatory bowel disease10.0MMP1, IL1RAPL2, XDH
46atherosclerosis10.0ENPP1, MMP1, IL1RAPL2, XDH
47brachydactyly9.9
48short bowel syndrome9.9
49osteopoikilosis9.9
50hypercalcemia9.9

Graphical network of the top 20 diseases related to Pseudogout:



Diseases related to pseudogout

Clinical Features for Pseudogout

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Drugs & Therapeutics for Pseudogout

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pseudogout

Genetic Tests for Pseudogout

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Anatomical Context for Pseudogout

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pseudogout:

32
Bone, Liver, Thyroid, Testes

FMA organs/tissues related to Pseudogout:

14
Joint

Animal Models for Pseudogout or affiliated genes

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Publications for Pseudogout

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50PubMed
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Articles related to Pseudogout:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Bilateral pseudogout 8 years after bilateral total knee arthroplasty. (23102423)
2012
2
Treatment and management of pseudogout: insights for the clinician. (22870500)
2012
3
Mimicry in older patients: tophaceous pseudogout as a tumorlike lesion: a case report. (21957280)
2011
4
Monoarticular pseudogout of the hip presenting as septic arthritis: a case report. (21765235)
2011
5
Acute pseudogout following intravenous neridronate for osteoporosis. (20439533)
2010
6
By the way, doctor. I've been diagnosed with pseudogout, which I understand is caused by a buildup of calcium crystals in the joints. Should I be concerned about taking a calcium supplement? (19777676)
2009
7
Does acute synovitis (pseudogout) occur in patients with chronic pyrophosphate arthropathy (pseudo-osteoarthritis)? (20149309)
2009
8
Pseudogout of the transverse atlantal ligament: an unusual cause of cervical myelopathy. (15198459)
2004
9
Pseudogout, hypomagnesemia, and liver transplantation. (12010609)
2002
10
Evaluation of crystals in formalin-fixed, paraffin-embedded tissue sections for the differential diagnosis of pseudogout, gout, and tumoral calcinosis. (11504841)
2001
11
Tophaceous pseudogout of the sternoclavicular joint. (10350294)
1999
12
Association of Paget's disease of bone with articular chondrocalcinosis and pseudogout. (9712120)
1998
13
Pseudogout following intraarticular injection of sodium hyaluronate. (9588748)
1998
14
Tophaceous pseudogout of the temporomandibular joint: report of a case. (9293541)
1997
15
Exacerbation of pseudogout by granulocyte colony-stimulating factor. (8929025)
1996
16
Evidence for a causal relationship between the structure, size, and load of calcium pyrophosphate dihydrate crystals, and attacks of pseudogout. (7492222)
1995
17
Two cases of acute pseudogout attack following parathyroidectomy. (1794338)
1991
18
Pseudogout and pseudosepsis of the shoulder. (2251236)
1990
19
Foramen magnum syndrome from pseudogout of the atlanto-occipital ligament. Case report. (2738632)
1989
20
Clinical pattern of females with crystal-induced arthritis: gout and pseudogout. (2786918)
1989
21
Pseudogout associated with primary hyperparathyroidism: management in the immediate postoperative period for prevention of acute pseudogout attack. (3215148)
1988
22
Acute pseudogout mimicking septic arthritis following urologic manipulation. (3174209)
1988
23
Pseudogout following parathyroidectomy. (3437115)
1987
24
Prevention of acute attacks of pseudogout with oral colchicine. (3625651)
1987
25
Destructive calcium pyrophosphate dihydrate temporo-mandibular arthropathy (pseudogout). (3125275)
1987
26
Gout and pseudogout of the temporomandibular joint. (3473375)
1987
27
Acute pseudogout after oral glucose tolerance test. (6663588)
1983
28
The destructive wrist arthropathy of pseudogout. (7071623)
1982
29
Tophaceous pseudogout. (6976696)
1982
30
Simultaneous gout, pseudogout, and septic arthritis. (7352936)
1980
31
Subcutaneous crystal deposition in pseudogout. (6253693)
1980
32
Acute pseudogout simulating septic arthritis. (480605)
1979
33
Tenosynovial cysts and pseudogout. (921835)
1977
34
Clinical, radiographic and pathologic abnormalities in calcium pyrophosphate dihydrate deposition disease (CPPD): pseudogout. (186841)
1977
35
Acute pseudogout in the absence of synovial fluid Leukocytes. (926107)
1977
36
Roentgenographic aspects of calcium pyrophosphate dihydrate crystal deposition disease (pseudogout). (181013)
1976
37
Calcium pyrophosphate. Histological characterization of crystals in pseudogout. (175762)
1976
38
Ultrastructural findings in chondrocalcinosis and pseudogout. (181017)
1976
39
Chondrocalcinosis and pseudogout. (4349286)
1973
40
Pseudogout after parathyroidectomy. (4120363)
1973
41
Pseudogout syndrome in hospital patients. (4361132)
1973
42
A roentgenologically distinctive arthropathy in some patients with the pseudogout syndrome. (5431507)
1970
43
Pseudogout with low values of alkaline phosphatase in the synovial fluid. (5476207)
1970
44
Inorganic pyrophosphate in plasma, urine, and synovial fluid of patients with pyrophosphate arthropathy (chondrocalcinosis or pseudogout). (4097282)
1970
45
Chondrocalcinosis and pseudogout. (5364640)
1969
46
A comparative study of roentgenographic techniques for detection of calcium pyrophosphate dihydrate deposits (pseudogout) in human cartilage. (4289859)
1967
47
Articular chondrocalcinosis, hyperparathyroidism and pseudogout: hypomagnesaemic crisis. (5939496)
1966
48
Familial joint chondrocalcinosis (pseudogout syndrome). (5948946)
1966
49
Pseudogout simulating acute suppurative arthritis. (5909066)
1966
50
PSEUDOGOUT. (14338826)
1965

Genetic Variations for Pseudogout

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Expression for genes affiliated with Pseudogout

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pseudogout

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Pathways for genes affiliated with Pseudogout

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Compounds for genes affiliated with Pseudogout

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pseudogout according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4410.0PPA1
2trolox449.9XDH, MMP1
3leflunomide49 44 1111.9MMP1, IL1RAPL2
4ethidium bromide449.9MMP1, XDH
5etanercept44 49 1111.8IL1RAPL2, MMP1
6infliximab44 49 1111.8MMP1, IL1RAPL2
7pentoxifylline44 1110.7MMP1, IL1RAPL2
8ribavirin44 49 1111.7MMP1, ENPP1
9rotenone449.7IL1RAPL2, XDH
10guanine44 11 2411.5SLC12A3, MMP1, XDH
11salicylic acid44 2810.4XDH, IL1RAPL2
12spermine44 28 11 2412.3PPA1, XDH
13hydroxyapatite449.2ENPP1, ANKH
14superoxide44 2410.1IL1RAPL2, PPA1
15ascorbic acid44 2410.1MMP1, XDH, PPA1
1612-o-tetradecanoylphorbol 13-acetate449.0PPA1, IL1RAPL2, MMP1
17nacl449.0SLC12A3, IL1RAPL2, PPA1
18lactate449.0MMP1, IL1RAPL2, XDH
19pyrophosphate44 249.9ENPP1, ANKH, PPA1
20cyclosporin a44 28 5910.8MMP1, IL1RAPL2, PPA1
21serine448.6PPA1, IL1RAPL2, MMP1, SLC12A3
22h2o2448.6PPA1, XDH, IL1RAPL2, MMP1
23threonine448.4PPA1, IL1RAPL2, SLC12A3, ENPP1
24calcium44 49 11 2410.7ENPP1, SLC12A3, MMP1, IL1RAPL2, ANKH, PPA1

GO Terms for genes affiliated with Pseudogout

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16Gene Ontology
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Biological processes related to Pseudogout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of bone mineralizationGO:0305009.2ENPP1, ANKH
2phosphate-containing compound metabolic processGO:0067969.0ENPP1, PPA1

Products for genes affiliated with Pseudogout

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Sources for Pseudogout

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet