MCID: PSD010
MIFTS: 45

Pseudogout malady

Bone diseases category
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Summaries for Pseudogout

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as chondrocalcinosis,... more...

MalaCards: Pseudogout, also known as calcium pyrophosphate deposition disease, is related to gout and arthritis. An important gene associated with Pseudogout is ANKH (ANKH inorganic pyrophosphate transport regulator), and among its related pathways is Glucuronidation. The compounds leflunomide and etanercept have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and liver.

Disease Ontology:8 An arthritis that has material basis in the accumulation of salt crystals located in joint.

Aliases & Classifications for Pseudogout

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

pseudogout 8 10 45 62
calcium pyrophosphate deposition disease 8 62
chondrocalcinosis 8 45


External Ids:

Disease Ontology8 DOID:1156
NCIt40 C34955
MeSH35 D002805

Related Diseases for Pseudogout

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pseudogout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.1BCKDHA, XDH
2arthritis30.9IL1RAPL2, MMP1, ANKH
3arthropathy30.7ANKH, IL1RAPL2, MMP1
4calcinosis30.2ANKH, ENPP1
5osteoarthritis30.1ANKH, ENPP1, MMP1, XDH, IL1RAPL2
6septic arthritis10.4
7cervicitis10.4
8hyperparathyroidism10.4
9chondrocalcinosis 110.3
10polymyalgia rheumatica10.3
11carpal tunnel syndrome10.3
12gitelman syndrome10.3
13chondrocalcinosis due to apatite crystal deposition10.2
14spinal stenosis10.2
15primary hyperparathyroidism10.2
16rheumatoid arthritis10.2
17diffuse idiopathic skeletal hyperostosis10.1
18hyperostosis10.1
19hyperphosphatemic familial tumoral calcinosis10.1
20acromegaly10.1
21tuberculosis10.1
22chondrocalcinosis 210.1
23synovial chondromatosis10.1
24sepsis10.1
25ankylosis10.1ENPP1
26psoriatic arthritis10.0MMP1, IL1RAPL2
27ankylosing spondylitis10.0ANKH, IL1RAPL2
28craniosynostosis10.0ENPP1, ANKH
29periodontitis10.0IL1RAPL2, MMP1
30idiopathic pulmonary fibrosis10.0MMP1, IL1RAPL2
31periodontal disease10.0MMP1, IL1RAPL2
32hyperuricemia10.0BCKDHA, XDH
33endometriosis10.0XDH, MMP1
34pulmonary disease, chronic obstructive10.0MMP1, XDH
35septic shock10.0XDH, IL1RAPL2
36inflammatory bowel disease10.0XDH, IL1RAPL2, MMP1
37short bowel syndrome10.0
38osteopoikilosis10.0
39hypercalcemia10.0
40hypokalemia10.0
41brachydactyly10.0
42hypophosphatasia10.0
43craniometaphyseal dysplasia10.0
44familial hypocalciuric hypercalcemia10.0
45normophosphatemic familial tumoral calcinosis10.0
46hypocalciuric hypercalcemia, type i10.0
47giant cell reparative granuloma9.9
48discitis9.9
49paget's disease of bone9.9
50end stage renal failure9.9

Graphical network of the top 20 diseases related to Pseudogout:



Diseases related to pseudogout

Symptoms for Pseudogout

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Drugs & Therapeutics for Pseudogout

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pseudogout

Search NIH Clinical Center for Pseudogout

Genetic Tests for Pseudogout

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Anatomical Context for Pseudogout

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Pseudogout:

33
Bone, Liver, Testes, Thyroid

FMA organs/tissues related to Pseudogout:

14
Joint

Animal Models for Pseudogout or affiliated genes

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Publications for Pseudogout

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52PubMed
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Articles related to Pseudogout:

(show top 50)    (show all 287)
idTitleAuthorsYear
1
Huge tophaceous pseudogout associated with tenosynovial chondromatosis arising from flexor digitorum tendon sheaths of the foot: a case report. (23828620)
2013
2
Pathology quiz case 2. Tophaceous pseudogout (calcium pyrophosphate deposition disease [CPDD]) of the TMJ. (22986729)
2012
3
Cauda equina syndrome caused by pseudogout involving the lumbar intervertebral disc. (23255864)
2012
4
Recurrent parotid pseudogout. (23033502)
2012
5
The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis). (22303529)
2011
6
Mimicry in older patients: tophaceous pseudogout as a tumorlike lesion: a case report. (21957280)
2011
7
By the way, doctor. I've been diagnosed with pseudogout, which I understand is caused by a buildup of calcium crystals in the joints. Should I be concerned about taking a calcium supplement? (19777676)
2009
8
Weekly alendronate-induced acute pseudogout. (15611307)
2005
9
Temporomandibular joint pseudogout: an uncommon site for a familiar condition. (15547106)
2004
10
Questions & answers. What's the difference between gout and pseudogout? (14679973)
2003
11
Tumoral pseudogout of the metatarsal. (11807592)
2002
12
Evaluation of crystals in formalin-fixed, paraffin-embedded tissue sections for the differential diagnosis of pseudogout, gout, and tumoral calcinosis. (11504841)
2001
13
Possible causes of acute pseudogout in older patients with osteoarthritis. (10991746)
2000
14
Tophaceous pseudogout of the mitral valve. (9768968)
1998
15
Prospective use of intramuscular triamcinolone acetonide in pseudogout. (9195527)
1997
16
Cervical spine pseudogout with myelopathy and Charcot joints. (8856629)
1996
17
Coexistence of pseudogout and arthritis due to Actinobacillus actinomycetemcomitans. (8879809)
1996
18
Bilateral pseudogout of the temporomandibular joint: report of case and review of literature. (7776053)
1995
19
Pseudogout mimicking meningitis. (8461939)
1993
20
Lumbar spinal stenosis secondary to calcium pyrophosphate crystal deposition (pseudogout). (8472402)
1993
21
Gout and pseudogout in hospitalized patients. (8257255)
1993
22
Acute carpal tunnel syndrome due to pseudogout. (8345281)
1993
23
Gout and pseudogout. (8310084)
1993
24
A case of pseudo pseudogout. (1735756)
1992
25
Pseudogout of the ankle: a case study and arthroscopic-assisted treatment. (1865072)
1991
26
Pseudogout associated with primary hyperparathyroidism: management in the immediate postoperative period for prevention of acute pseudogout attack. (3215148)
1988
27
Pseudoseptic pseudogout in progressive pseudorheumatoid arthritis of childhood. (3675014)
1987
28
Pseudogout following parathyroidectomy. (3437115)
1987
29
Pseudogout in a patient on renal dialysis. (3456088)
1986
30
Septic arthritis and pseudogout. (4087257)
1985
31
Histologic differentiation of gout and pseudogout using polarized light. (6546859)
1984
32
Acute pseudogout after oral glucose tolerance test. (6663588)
1983
33
Gout and pseudogout precipitated by parathyroidectomy. (7112087)
1982
34
The destructive wrist arthropathy of pseudogout. (7071623)
1982
35
Gout, pseudogout and rheumatoid arthritis in an elderly patient. (7123105)
1982
36
Colchicine and pseudogout. (7150388)
1982
37
Narrowing of knee joint space in patients with pseudogout. (7469524)
1981
38
Clinical and roentgenographic aspects of pseudogout: a study of 50 cases and a review. (7008926)
1981
39
Acute pseudogout: "crystal shedding" or acute crystallization? (6266426)
1981
40
Acute pseudogout simulating septic arthritis. (480605)
1979
41
Elevated inorganic pyrophosphate concentrations in synovial fluids in osteoarthritis and pseudogout. (4361744)
1974
42
Chondrocalcinosis articularis (pseudogout syndrome). (4541464)
1973
43
Pseudogout. (4354552)
1972-1973
44
Erythrocyte neutral inorganic pyrophosphatase in pseudogout. (5009714)
1972
45
Pseudogout. (5541153)
1971
46
Alkaline phosphatase in pseudogout. (4185629)
1969
47
Basal urinary pyrophosphate excretion in pseudogout. (4306837)
1969
48
Chondrocalcinosis (pseudogout). (5937364)
1966
49
Pseudogout vs. gout. (5946796)
1966
50
PSEUDOGOUT. (14338826)
1965

Variations for Pseudogout

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Expression for genes affiliated with Pseudogout

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pseudogout

Search GEO for disease gene expression data for Pseudogout.

Pathways for genes affiliated with Pseudogout

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50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Pseudogout according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3ENPP1, XDH

Compounds for genes affiliated with Pseudogout

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Pseudogout according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1leflunomide45 51 1111.9MMP1, IL1RAPL2
2etanercept45 51 1111.9IL1RAPL2, MMP1
3infliximab45 51 1111.9MMP1, IL1RAPL2
4hydroxyapatite459.9ENPP1, ANKH
5ribavirin45 51 1111.9MMP1, ENPP1
6pentoxifylline45 1110.9IL1RAPL2, MMP1
7trolox459.8MMP1, XDH
8ethidium bromide459.8MMP1, XDH
9glycosaminoglycan459.8IL1RAPL2, MMP1
10pdtc459.7MMP1, XDH
11losartan45 51 29 1112.7MMP1, XDH
12prednisolone45 29 1111.7MMP1, IL1RAPL2
13rotenone459.7XDH, IL1RAPL2
144-hydroxynonenal45 2410.7MMP1, XDH
15salicylic acid45 2910.6XDH, IL1RAPL2
16rosiglitazone29 45 51 24 1113.6IL1RAPL2, MMP1
17sulfate45 2410.5IL1RAPL2, ENPP1
18cytochalasin d45 6110.4MMP1, IL1RAPL2
19egcg459.4XDH, MMP1
20spermine29 45 24 1112.4PPA1, XDH
21lactate459.3MMP1, XDH, IL1RAPL2
22dexamethasone45 51 29 1112.2ENPP1, MMP1, IL1RAPL2
23pyrophosphate45 2410.1ANKH, PPA1, ENPP1
2412-o-tetradecanoylphorbol 13-acetate459.1PPA1, MMP1, IL1RAPL2
25cyclosporin a45 29 6111.1MMP1, PPA1, IL1RAPL2
26alpha tocopherol459.0XDH, MMP1, PPA1
27ascorbic acid45 2410.0XDH, PPA1, MMP1
28superoxide45 249.9PPA1, XDH, IL1RAPL2
29Water248.7XDH, ENPP1, PPA1
30nitric oxide45 24 1110.5IL1RAPL2, XDH, PPA1
31h2o2458.5MMP1, IL1RAPL2, PPA1, XDH
32serine458.5IL1RAPL2, MMP1, PPA1, ENPP1
33threonine458.3PPA1, ENPP1, IL1RAPL2
34calcium45 51 24 1111.2MMP1, PPA1, ENPP1, IL1RAPL2, ANKH

GO Terms for genes affiliated with Pseudogout

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16Gene Ontology
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Biological processes related to Pseudogout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inorganic diphosphate transportGO:0305059.5ENPP1, ANKH
2regulation of bone mineralizationGO:0305009.3ENPP1, ANKH
3phosphate-containing compound metabolic processGO:0067969.1ENPP1, PPA1

Products for genes affiliated with Pseudogout

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Sources for Pseudogout

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet