MCID: PSD010
MIFTS: 42

Pseudogout malady

Summaries for Pseudogout

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as chondrocalcinosis,... more...

MalaCards: Pseudogout, also known as calcium pyrophosphate deposition disease, is related to gout and arthritis. An important gene associated with Pseudogout is ANKH (ANKH inorganic pyrophosphate transport regulator). The compounds alpha tocopherol and trolox have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and liver.

Disease Ontology:8 An arthritis that has material basis in the accumulation of salt crystals located in joint.

Aliases & Classifications for Pseudogout

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

pseudogout 8 10 44 60
calcium pyrophosphate deposition disease 8 60
chondrocalcinosis 8 44


External Ids:

Disease Ontology8 DOID:1156
MeSH34 D002805
NCIt39 C34955

Related Diseases for Pseudogout

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pseudogout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1gout31.0BCKDHA, XDH
2arthritis30.8ANKH, IL1RAPL2, MMP1
3arthropathy30.6ANKH, IL1RAPL2, MMP1
4osteoarthritis30.3ANKH, XDH, IL1RAPL2, MMP1, ENPP1
5synovitis30.0MMP1
6tuberculosis30.0IL1RAPL2
7calcinosis30.0ANKH, ENPP1
8hypophosphatasia29.8ENPP1
9septic arthritis10.4
10cervicitis10.3
11hyperparathyroidism10.3
12polymyalgia rheumatica10.3
13chondrocalcinosis 110.3
14carpal tunnel syndrome10.2
15gitelman syndrome10.2
16familial articular chondrocalcinosis type 110.2
17chondrocalcinosis due to apatite crystal deposition10.1
18familial articular chondrocalcinosis type 210.1
19primary hyperparathyroidism10.1
20spinal stenosis10.1
21rheumatoid arthritis10.1
22diffuse idiopathic skeletal hyperostosis10.1
23hyperostosis10.1
24hyperphosphatemic familial tumoral calcinosis10.1
25acromegaly10.0
26primary hyperoxaluria10.0SLC12A3
27sjogren's syndrome10.0IL1RAPL2
28dilated cardiomyopathy10.0MMP1
29hepatitis c10.0IL1RAPL2
30acute myocardial infarction10.0XDH
31ankylosis10.0ENPP1
32psoriatic arthritis10.0IL1RAPL2, MMP1
33ankylosing spondylitis10.0ANKH, IL1RAPL2
34diabetes mellitus10.0ENPP1
35periodontitis10.0MMP1, IL1RAPL2
36malaria10.0XDH
37obesity10.0ENPP1
38hepatitis10.0IL1RAPL2, XDH
39idiopathic pulmonary fibrosis10.0MMP1, IL1RAPL2
40hyperuricemia10.0BCKDHA, XDH
41pneumonia10.0IL1RAPL2, XDH
42periodontal disease10.0MMP1, IL1RAPL2
43coronary heart disease10.0XDH
44myocardial infarction10.0ENPP1, IL1RAPL2
45inflammatory bowel disease10.0MMP1, IL1RAPL2, XDH
46atherosclerosis10.0ENPP1, MMP1, IL1RAPL2, XDH
47brachydactyly9.9
48short bowel syndrome9.9
49osteopoikilosis9.9
50hypercalcemia9.9

Graphical network of the top 20 diseases related to Pseudogout:



Diseases related to pseudogout

Clinical Features for Pseudogout

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Drugs & Therapeutics for Pseudogout

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pseudogout

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Anatomical Context for Pseudogout

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pseudogout:

32
Bone, Liver, Testes, Thyroid

FMA organs/tissues related to Pseudogout:

14
Joint

Animal Models for Pseudogout or affiliated genes

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Publications for Pseudogout

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50PubMed
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Articles related to Pseudogout:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Huge tophaceous pseudogout associated with tenosynovial chondromatosis arising from flexor digitorum tendon sheaths of the foot: a case report. (23828620)
2013
2
Acute lumbar spinal pseudogout attack after instrumented surgery. (22858786)
2012
3
Synovial chondromatosis of the temporomandibular joint with calcium pyrophosphate dihydrate crystal deposition disease (pseudogout). (23166363)
2012
4
Pseudogout Associated Hip Pain in a Patient with HIV Infection. (21209737)
2010
5
Pseudogout after polyethylene glycol bowel cleansing. (18528291)
2009
6
Articular gout and suspected pseudogout in a Basilisk lizard (Basilicus plumifrons). (19746877)
2009
7
Tumoural calcium pyrophosphate dihydrate crystal deposition disease (tophaceous pseudogout) of the hand: a report of two cases including one with a previously unreported associated florid reactive myofibroblastic proliferation. (18985528)
2008
8
Pseudogout after total knee arthroplasty. (17275646)
2007
9
Cervical myelopathy induced by pseudogout in ligamentum flavum and retro-odontoid mass: a case report. (16344849)
2006
10
Disease dictionary. Pseudogout. (14639249)
2003
11
Pseudogout and gout in a patient after liver transplantation for primary biliary cirrhosis: what might be the association? (17041459)
2003
12
Mycobacterium tuberculosis infection of a tophaceous pseudogout nodule. (12022329)
2002
13
Bilateral temporomandibular joint pseudogout. (11843007)
2002
14
Invasive tophaceous pseudogout in the temporomandibular joint: misdiagnosis as tumor: case report and review of the literature. (19078485)
2000
15
Pseudogout: timing of attacks and the cosmogeophysical environment. (10949729)
2000
16
Bilateral simultaneous atraumatic quadriceps tendon ruptures associated with 'pseudogout'. (10831749)
2000
17
Acute pseudogout following intra-articular injection of high molecular weight hyaluronic acid. (10625037)
1999
18
Pseudogout in a young patient. (9694062)
1998
19
Iliopsoas bursitis and pseudogout of the knee mimicking L2-L3 radiculopathy: case report and review of the literature. (9391806)
1997
20
Coexistence of pseudogout and arthritis due to Actinobacillus actinomycetemcomitans. (8879809)
1996
21
Calcium pyrophosphate dihydrate deposition disease presenting as tumoral calcinosis (periarticular pseudogout). (8877941)
1996
22
Tophaceous pseudogout. (8915062)
1996
23
Bilateral pseudogout of the temporomandibular joint: report of case and review of literature. (7776053)
1995
24
Gout and 'pseudogout'. When are arthritic symptoms caused by crystal deposition? (8309855)
1994
25
Lumbar spinal stenosis secondary to calcium pyrophosphate crystal deposition (pseudogout). (8472402)
1993
26
Gout and pseudogout. (8310084)
1993
27
Pseudogout provoked by pregnancy. (8448618)
1993
28
Acute carpal tunnel syndrome due to pseudogout. (1340761)
1992
29
Bartter's syndrome presenting as pseudomyocardial infarction and pseudogout. (1286962)
1992
30
Acute pseudogout following parathyroidectomy. (3395029)
1988
31
Pseudoseptic pseudogout in progressive pseudorheumatoid arthritis of childhood. (3675014)
1987
32
Colchicine prophylaxis in pseudogout. (3772928)
1986
33
Septic arthritis and pseudogout. (4087257)
1985
34
Pseudogout with low values of magnesium and low alkaline phosphatase activity in synovial fluid. (6643023)
1983
35
Narrowing of knee joint space in patients with pseudogout. (7469524)
1981
36
Acute pseudogout and chrondrocalcinosis in a man with mild hemophilia. (7310779)
1981
37
Colchicine and pseudogout. (426887)
1979
38
Crystal-induced arthropathy. Gout and pseudogout. (490862)
1979
39
Relative frequency of gout and pseudogout. (426888)
1979
40
Acute pseudogout attack following parathyroidectomy. (734313)
1978
41
Synovial membrane histopathology in the differential diagnosis of rheumatoid arthritis, gout, pseudogout, systemic lupus erythematosus, infectious arthritis and degenerative joint disease. (642792)
1978
42
Crystal induced arthritis: gout and pseudogout. (708317)
1978
43
Pseudogout: session I. Clinical features: discussion. (938600)
1976
44
Pseudogout: clinical observations and chemical analyses of deposits. (181012)
1976
45
Clinical studies of acute pseudogout attacks: comments on prevalence, predispositions, and treatment. (181014)
1976
46
Hemarthrosis in chondrocalcinosis (pseudogout). (5086530)
1972
47
Septic arthritis, gout, pseudogout and osteoarthritis in the knee of a patient with multiple myeloma. (4333902)
1972
48
High urinary pyrophosphate excretion in the acute phase of pseudogout. (4317862)
1970
49
Alkaline phosphatase in pseudogout. (4185629)
1969
50
PRIMARY ARTICULAR-CARTILAGE CALCIFICATION WITH ARTHRITIS (PSEUDOGOUT SYNDROME). (14256958)
1965

Genetic Variations for Pseudogout

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Expression for genes affiliated with Pseudogout

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pseudogout

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Pathways for genes affiliated with Pseudogout

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Compounds for genes affiliated with Pseudogout

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pseudogout according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4410.0PPA1
2trolox449.9XDH, MMP1
3leflunomide49 44 1111.9MMP1, IL1RAPL2
4ethidium bromide449.9MMP1, XDH
5etanercept44 49 1111.8IL1RAPL2, MMP1
6infliximab44 49 1111.8MMP1, IL1RAPL2
7pentoxifylline44 1110.7MMP1, IL1RAPL2
8ribavirin44 49 1111.7MMP1, ENPP1
9rotenone449.7IL1RAPL2, XDH
10guanine44 11 2411.5SLC12A3, MMP1, XDH
11salicylic acid44 2810.4XDH, IL1RAPL2
12spermine44 28 11 2412.3PPA1, XDH
13hydroxyapatite449.2ENPP1, ANKH
14superoxide44 2410.1IL1RAPL2, PPA1
15ascorbic acid44 2410.1MMP1, XDH, PPA1
1612-o-tetradecanoylphorbol 13-acetate449.0PPA1, IL1RAPL2, MMP1
17nacl449.0SLC12A3, IL1RAPL2, PPA1
18lactate449.0MMP1, IL1RAPL2, XDH
19pyrophosphate44 249.9ENPP1, ANKH, PPA1
20cyclosporin a44 28 5910.8MMP1, IL1RAPL2, PPA1
21serine448.6PPA1, IL1RAPL2, MMP1, SLC12A3
22h2o2448.6PPA1, XDH, IL1RAPL2, MMP1
23threonine448.4PPA1, IL1RAPL2, SLC12A3, ENPP1
24calcium44 49 11 2410.7ENPP1, SLC12A3, MMP1, IL1RAPL2, ANKH, PPA1

GO Terms for genes affiliated with Pseudogout

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16Gene Ontology
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Biological processes related to Pseudogout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of bone mineralizationGO:0305009.2ENPP1, ANKH
2phosphate-containing compound metabolic processGO:0067969.0ENPP1, PPA1

Products for genes affiliated with Pseudogout

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  • Antibodies
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  • Antibodies

Sources for Pseudogout

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet