MCID: PSD007
MIFTS: 59

Pseudomyxoma Peritonei malady

Rare diseases, Cancer diseases categories

Summaries for Pseudomyxoma Peritonei

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NIH Rare Diseases:41 Pseudomyxoma peritonei is a tumor that most often begins in the appendix.  as the tumor grows, tumor cells may spread into the peritoneal cavity and land on other nearby organs (such as the ovaries or intestines), sometimes forming additional tumors on the surface of these organs.  pseudomyxoma peritonei is extremely unlikely to grow into these organs (to become invasive) or spread to more distant parts of the body (metastasize); therefore, it is not usually thought of as a malignant tumor.  it is rare, occurring in approximately two out of a million people, and women are affected two to three times more frequently than men.  the first symptoms of pseudomyxoma peritonei are an increase in the size of the belly, appendicitis, or the finding of a mass on the ovary during medical imaging tests.   last updated: 9/27/2011

MalaCards based summary: Pseudomyxoma Peritonei, also known as gelatinous ascites, is related to cystadenocarcinoma and mucinous cystadenocarcinoma, and has symptoms including ascites, abnormality of the peritoneum and abnormality of the abdominal wall. An important gene associated with Pseudomyxoma Peritonei is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Incretin Synthesis, Secretion, and Inactivation and Selected targets of Oct 3 4. The compounds exisulind and sodium bisulfite have been mentioned in the context of this disorder. Affiliated tissues include appendix, colon and ovary, and related mouse phenotypes are pigmentation and tumorigenesis.

Disease Ontology:9 An appendix cancer that is characterized by progressive accumulation of mucus-secreting tumor cells within the abdomen and pelvis.

Wikipedia:63 Pseudomyxoma peritonei is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that... more...

Aliases & Classifications for Pseudomyxoma Peritonei

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet
See all sources

Pseudomyxoma Peritonei, Aliases & Descriptions:

Name: Pseudomyxoma Peritonei 9 41 11 43 47 60
Gelatinous Ascites 41 47
Adenomucinosis 41 47
 
Pmp 41 47
Syndrome of Pseudomyxoma Peritonei 41
Mucinous Ascites 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
pseudomyxoma peritonei:
Prevalence: 1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: any age


External Ids:

Disease Ontology9 DOID:3559
MeSH33 D011553
NCIt38 C3345
Orphanet47 26790
ICD10 via Orphanet26 C78.6
UMLS via Orphanet61 C0033822
MESH via Orphanet34 D011553

Related Diseases for Pseudomyxoma Peritonei

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Diseases related to Pseudomyxoma Peritonei via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenocarcinoma31.7CEACAM5, MUC5AC, MUC2
2mucinous cystadenocarcinoma31.7KRT20, KRT7, CEACAM7
3cystadenoma31.4KRT7, KRAS
4villous adenoma30.9MUC5AC, APC
5colorectal cancer30.6CTNNB1, APC
6mesothelioma30.2CDH2, KRT20, KRT7, PSG2, CEACAM7, CEACAM5
7breast cancer30.2CDH1, TP53
8adenocarcinoma28.7CTNNB1, CDH2, CDH1, CDX2, KRT20, KRT7
9melanoma28.6CTNNB1, CDH2, CDH1, CDX2, KRAS, PSG2
10adenoma28.1CTNNB1, CDH2, CDH1, CDX2, KRT20, KRT7
11peritonitis11.0
12mucinous adenocarcinoma10.9
13teratoma10.7
14cystic teratoma10.7
15ampulla of vater carcinoma10.6MUC2
16mucinous adenocarcinoma of the appendix10.6
17bladder adenocarcinoma10.6CDX2
18endometriosis10.5
19metanephric adenoma10.5KRT7
20inverted papilloma10.5KRT20
21peritoneal mesothelioma10.5
22appendiceal neoplasm10.5
23intestinal neoplasm10.5APC
24papilloma10.5MUC5AC, MUC2
25gastric cancer risk after h. pylori infection10.4CDH1
26mammary paget's disease10.4KRT20, KRT7
27ovarian brenner tumor10.4KRT20, KRT7
28polyposis, juvenile intestinal10.4APC
29pericardial effusion10.4PSG2
30adenomatoid tumor10.4VIM
31bronchogenic carcinoma10.4PSG2, CEACAM7
32papillary adenocarcinoma10.4CEACAM5, MUC2
33hepatitis10.4
34ovarian mucinous cystadenocarcinoma10.4
35intestinal obstruction10.4
36gelatinous ascites10.4
37urachal cyst10.4
38pleural tuberculosis10.4PSG2, CEACAM7
39paget disease, extramammary10.4KRT20, KRT7, CEACAM7
40endodermal sinus tumor10.4KRT7, CEACAM5
41lung squamous cell carcinoma10.3PSG2, CEACAM5
42papillary craniopharyngioma10.3CTNNB1, KRT7
43biliary papillomatosis10.3MUC6, MUC5B, MUC2
44neuroendocrine tumor10.3CDX2, KRT20, PSG2
45gastrointestinal carcinoma10.3KRT20, CEACAM7, CEACAM5
46gastric cancer, somatic10.3KRAS, APC
47acinar cell carcinoma10.3CTNNB1, KRT7
48meningioma, familial10.3PSG2, VIM
49mismatch repair cancer syndrome10.3CTNNB1, APC
50carcinoid syndrome10.3CDX2, KRT20, CEACAM5

Graphical network of the top 20 diseases related to Pseudomyxoma Peritonei:



Diseases related to pseudomyxoma peritonei

Symptoms for Pseudomyxoma Peritonei

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Symptoms:

 47 (show all 19)
  • anomalies of the abdominal wall
  • ascitis
  • peritoneal diseases
  • inflammatory intestinal disease
  • herniae
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • constipation
  • intestinal obstruction/ileus
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • lymphadenopathy/polyadenopathies
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • digestive neoplasm/tumor/carcinoma/cancer
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • colon neoplasm/tumor/carcinoma/cancer
  • pancreatic/pancreas neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration

HPO human phenotypes related to Pseudomyxoma Peritonei:

(show all 17)
id Description Frequency HPO Source Accession
1 ascites hallmark (90%) HP:0001541
2 abnormality of the peritoneum hallmark (90%) HP:0002585
3 abnormality of the abdominal wall hallmark (90%) HP:0004298
4 inflammation of the large intestine typical (50%) HP:0002037
5 weight loss occasional (7.5%) HP:0001824
6 nausea and vomiting occasional (7.5%) HP:0002017
7 constipation occasional (7.5%) HP:0002019
8 abdominal pain occasional (7.5%) HP:0002027
9 respiratory insufficiency occasional (7.5%) HP:0002093
10 lymphadenopathy occasional (7.5%) HP:0002716
11 neoplasm of the pancreas occasional (7.5%) HP:0002894
12 intestinal obstruction occasional (7.5%) HP:0005214
13 neoplasm of the stomach occasional (7.5%) HP:0006753
14 abnormal renal physiology occasional (7.5%) HP:0012211
15 neoplasm of the colon occasional (7.5%) HP:0100273
16 ovarian neoplasm occasional (7.5%) HP:0100615
17 hernia occasional (7.5%) HP:0100790

Drugs & Therapeutics for Pseudomyxoma Peritonei

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Drug clinical trials:

Search ClinicalTrials for Pseudomyxoma Peritonei

Search NIH Clinical Center for Pseudomyxoma Peritonei

Genetic Tests for Pseudomyxoma Peritonei

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Anatomical Context for Pseudomyxoma Peritonei

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MalaCards organs/tissues related to Pseudomyxoma Peritonei:

31
Appendix, Colon, Ovary, Testes, Pancreas, Small intestine, Lung, Breast, Bone, Spleen, Kidney, Liver, Skin

Animal Models for Pseudomyxoma Peritonei or affiliated genes

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MGI Mouse Phenotypes related to Pseudomyxoma Peritonei:

35 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2CTNNB1, KRAS, TP53, APC
2MP:00020068.8APC, TP53, MUC2, KRAS, CDX2, CDH1
3MP:00053718.8APC, TP53, KRAS, CDX2, CTNNB1
4MP:00053798.7APC, TP53, MUC2, KRAS, CDX2, CDH1
5MP:00053698.7APC, TP53, VIM, KRAS, CDH2, CTNNB1
6MP:00107718.7CTNNB1, CDH1, KRAS, TP53, APC, F2
7MP:00028738.5F2, APC, TP53, KRAS, CDX2, CDH1
8MP:00053898.4F2, APC, TP53, VIM, KRAS, CDX2
9MP:00053818.2CTNNB1, F2, APC, TP53, MUC2, MUC5AC
10MP:00053808.2F2, APC, TP53, VIM, KRAS, CDX2
11MP:00053858.0F2, APC, TP53, VIM, MUC2, KRAS
12MP:00053877.9F2, APC, TP53, VIM, MUC2, MUC5AC
13MP:00053787.9F2, APC, TP53, VIM, MUC2, KRAS
14MP:00107687.8F2, APC, TP53, VIM, MUC2, KRAS
15MP:00053767.5F2, APC, TP53, VIM, MUC2, MUC5AC
16MP:00053847.5VIM, TP53, APC, F2, MUC2, KRAS

Publications for Pseudomyxoma Peritonei

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Articles related to Pseudomyxoma Peritonei:

(show top 50)    (show all 515)
idTitleAuthorsYear
1
A rare cause of ascites: pseudomyxoma peritonei and a review of the literature. (25838904)
2015
2
Multicentre study of the learning curve and surgical performance of cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei. (25329419)
2014
3
Appendiceal mucocele and pseudomyxoma peritonei; the clinical boundaries of a subtle disease. (25163976)
2014
4
Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis. (23199549)
2013
5
Aggressive pseudomyxoma peritonei: a case report with an unusual clinical presentation. (24324903)
2013
6
Role of preoperative sonography in the diagnosis and pathologic staging of pseudomyxoma peritonei. (23980216)
2013
7
Potential mucolytic agents for mucinous ascites from pseudomyxoma peritonei. (22359216)
2012
8
Pseudomyxoma peritonei (mucinous carcinoma peritonei) preceded by intraductal papillary neoplasm of the bile duct. (22406366)
2012
9
Mucolysis by ascorbic acid and hydrogen peroxide on compact mucin secreted in pseudomyxoma peritonei. (22261589)
2012
10
Evaluation of complete cytoreductive surgery and two intraperitoneal chemotherapy techniques in Pseudomyxoma peritonei. (22763244)
2012
11
Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. (22614976)
2012
12
Extraperitoneal presentation of pseudomyxoma peritonei as retroperitoneal invasion with skin fistula-a case report. (22202264)
2011
13
Commentary on 'Survival of patients with pseudomyxoma peritonei treated by serial debulking'. (20718839)
2010
14
Re: JSLS. 2009;13(2):203-206 Laparoscopic mucin removal in patients with pseudomyxoma peritonei. (20529543)
2010
15
Presumed fungal retinitis associated with pseudomyxoma peritonei. (21686849)
2009
16
Tailgut cyst, an unusual cause of pseudomyxoma peritonei. (19856666)
2009
17
Incidental finding of pseudomyxoma peritonei at primary cesarean section. (19399708)
2009
18
Chemo-hyperthermic peritoneal perfusion (CHPP) for appendiceal pseudomyxoma peritonei. (19390942)
2009
19
Adenocarcinoma of urachal cyst associated with pseudomyxoma peritonei masquerading as abdominal tuberculosis: A case report and review of literature. (19468408)
2008
20
Low-grade mucinous epithelial neoplasm (intestinal type) arising in a mature sacrococcygeal teratoma with late recurrence as pseudomyxoma peritonei. (18289636)
2008
21
Re: An evidence-based approach: Sugarbaker protocol and pseudomyxoma peritonei of appendiceal origin. (18959716)
2008
22
A phase II study evaluating the use of concurrent mitomycin C and capecitabine in patients with advanced unresectable pseudomyxoma peritonei. (18682713)
2008
23
Incidental finding of pseudomyxoma peritonei in a deceased organ donor: implications on organ donation. (17239029)
2007
24
Pseudomyxoma peritonei presenting with femoral hernias and peritonitis. (17508254)
2007
25
How safe and effective is surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei? (17667901)
2007
26
Toxicity and mortality of cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei--a report of 103 procedures. (16303281)
2006
27
Pseudomyxoma peritonei: A rose by any other name... (17063093)
2006
28
The etiology, clinical presentation, and management of pseudomyxoma peritonei. (14567019)
2003
29
Successful treatment of pseudomyxoma peritonei with intraperitoneal 10 per cent dextrose, sizofiran and cisplatin. (12521714)
2002
30
The subpyloric space: an important surgical and radiologic feature in pseudomyxoma peritonei. (12099657)
2002
31
Extensive surgical cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in patients with pseudomyxoma peritonei (Br J Surg 2001; 88: 458-63). (11488802)
2001
32
Use of ultrasonic surgical aspirator in operative cytoreduction of pseudomyxoma peritonei. (10789759)
2000
33
Pseudomyxoma peritonei in the pleural cavity: report of a case. (10211530)
1999
34
Pseudomyxoma peritonei. (9660531)
1998
35
Pseudomyxoma peritonei: a report of eight cases. (7829144)
1994
36
Pseudomyxoma peritonei with progressive calcifications: CT findings. (1544550)
1992
37
Pseudomyxoma peritonei from metastatic colloid carcinoma of the breast. (1846836)
1991
38
Pseudomyxoma peritonei--experience from a tertiary referral centre. (1930042)
1991
39
Clinical and radiological features of pseudomyxoma peritonei. (2530349)
1989
40
Pseudomyxoma peritonei--preoperative diagnosis on CT scan. A report of 2 cases. (3150267)
1988
41
Pseudomyxoma peritonei--benign or malignant. (3758624)
1986
42
Computed tomography and magnetic resonance of pseudomyxoma peritonei. (4056150)
1985
43
Successful treatment of pseudomyxoma peritonei of ovarian origin with cis-platinum, doxorubicin, and cyclophosphamide. (4054721)
1985
44
Pseudomyxoma peritonei associated with mucinous adenocarcinoma of the pancreas: CT findings and CT-guided biopsy. (6323557)
1984
45
Pseudomyxoma peritonei of ovarian origin--an autopsy case. (161472)
1979
46
Pseudomyxoma peritonei. (4645609)
1972
47
Pseudomyxoma peritonei. New concepts in management with a report of seventeen patients. (5773930)
1969
48
Bluish translucent umbilical lesions of pseudomyxoma peritonei. (6046394)
1967
49
Pseudomyxoma peritonei due to mucocele of the appendix. A report of four cases and review of the literature. (13777126)
1961
50
Pseudomyxoma peritonei. (13655140)
1959

Variations for Pseudomyxoma Peritonei

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Cosmic variations for Pseudomyxoma Peritonei:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1521KRASperitoneum,appendix,other,pseudomyxoma peritonei1

Expression for genes affiliated with Pseudomyxoma Peritonei

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Search GEO for disease gene expression data for Pseudomyxoma Peritonei.

Pathways for genes affiliated with Pseudomyxoma Peritonei

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Pathways related to Pseudomyxoma Peritonei according to GeneCards Suite gene sharing:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CTNNB1, CDX2
29.6APC, CDX2, CTNNB1
39.6CTNNB1, CDH2, APC
49.6CTNNB1, CDH2, CDH1
59.6CDH1, CDH2, CTNNB1
6
Show member pathways
9.6CTNNB1, CDH2, CDH1
79.6APC, CDH1, CTNNB1
89.6APC, CDH1, CTNNB1
9
Show member pathways
RAC1 signaling pathway36
9.6CTNNB1, CDH1, APC
109.6CTNNB1, CDH1, APC
119.5CTNNB1, CDH2, VIM
12
Show member pathways
9.5TP53, KRAS, CTNNB1
139.5CTNNB1, KRAS, TP53
149.5APC, TP53, CTNNB1
15
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.5CTNNB1, TP53, APC
169.5CTNNB1, CDH1, TP53
17
Show member pathways
9.4MUC5AC, MUC6, MUC5B, MUC2
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.4MUC2, MUC5B, MUC5AC, KRAS
199.3KRAS, VIM, TP53, APC
209.3APC, CDH1, CDH2, CTNNB1
219.3CTNNB1, KRAS, TP53, APC
229.3APC, TP53, KRAS, CTNNB1
23
Show member pathways
9.3APC, TP53, KRAS, CTNNB1
249.2TP53, KRAS, CDH1, CTNNB1
259.2CTNNB1, CDH1, KRAS, TP53
26
Show member pathways
Signaling Pathways in Glioblastoma36
9.2CTNNB1, CDH1, KRAS, TP53
27
Show member pathways
9.2CTNNB1, CDH1, VIM, APC
28
Show member pathways
Wnt Signaling Pathway NetPath36
9.2CTNNB1, CDH1, TP53, APC
299.2APC, TP53, CDH1, CTNNB1
309.0CEACAM5, CDH1, CDH2, CTNNB1
319.0CTNNB1, CDH2, CDH1, APC, F2
32
Show member pathways
9.0APC, VIM, CDH1, CDH2, CTNNB1
33
Show member pathways
Signal transduction PTEN pathway58
9.0APC, TP53, KRAS, CDH1, CTNNB1
349.0CTNNB1, CDH1, KRAS, TP53, APC
35
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.9APC, TP53, VIM, CDH1, CTNNB1
36
Show member pathways
8.6APC, TP53, VIM, CDH1, CDH2, CTNNB1
378.6CTNNB1, CDH2, CDH1, VIM, TP53, APC
38
Show member pathways
8.5F2, MUC2, MUC5B, MUC6, MUC5AC, CDX2

Compounds for genes affiliated with Pseudomyxoma Peritonei

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Compounds related to Pseudomyxoma Peritonei according to GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1exisulind439.8APC, CDH1, CTNNB1
2sodium bisulfite439.8CDH1, CTNNB1, APC
3aristolochic acid43 210.7TP53, CDH1, VIM
4o6-methylguanine439.7TP53, APC, CDH1, KRAS
5dicoumarol439.6TP53, F2, MUC5AC
6sulindac43 1210.5CTNNB1, APC, TP53, CDH1
75-methylcytosine43 2410.5APC, TP53, CDH1
8irinotecan43 49 1211.3TP53, CEACAM5, KRAS, CDH1
9cytosine43 2410.3CEACAM5, PSG2, CDH1, APC
10latex439.3CDH1, PSG2, CDH2, CEACAM5
11nocodazole43 1210.3VIM, CTNNB1, CDH1, TP53, APC
12p002439.2CDH1, CTNNB1, KRAS, PSG2, CEACAM5
13vitamin d439.1APC, CDH1, CTNNB1, CDX2, KRAS, VIM
14matrigel439.1CTNNB1, VIM, KRT7, CDH1, CDH2
15tamoxifen43 49 28 1212.0F2, TP53, VIM, CDH1, CTNNB1
16rapamycin439.0KRAS, VIM, APC, CTNNB1, CDH1
17n acetylcysteine439.0CDH1, MUC5AC, CTNNB1, F2, TP53
18carbohydrates438.9CDH1, CEACAM5, MUC5AC, MUC2, KRT7
19sb 20358043 599.9TP53, MUC5AC, VIM, MUC2, CDH1, CTNNB1
20methotrexate49 43 1210.9MUC2, VIM, KRT7, CDH1, MUC5AC, F2
21adriamycin438.8TP53, VIM, CDH1, CTNNB1, PSG2, CEACAM5
22crcs438.7CTNNB1, CDH1, APC, TP53, MUC2, CEACAM5
23formaldehyde43 249.7CDH1, VIM, KRT20, KRT7, PSG2
24retinoid438.7CDH1, MUC5AC, VIM, TP53, KRT7, CTNNB1
25paclitaxel43 49 1210.6CTNNB1, CDH1, KRAS, TP53, VIM
26polysaccharide438.6CTNNB1, CEACAM5, KRT7, MUC6, CDH2, MUC5AC
27sialic acid438.6PSG2, KRT7, CDH1, CEACAM5, MUC2, CDH2
28hyaluronic acid43 249.5CDH1, KRT20, CEACAM5, VIM, F2
29gefitinib43 49 1210.5KRAS, CDH1, CEACAM7, CTNNB1, CEACAM5, VIM
30thymidine43 249.5CEACAM7, PSG2, TP53, CEACAM5, CTNNB1, CDX2
31phosphatidylinositol438.4MUC5AC, APC, CEACAM5, KRAS, CDH1, CTNNB1
32cysteine438.3CTNNB1, MUC5AC, MUC2, CEACAM5, CDX2, CDH1
335-aza-2deoxycytidine438.2KRT7, CDX2, CDH1, CDH2, CTNNB1, MUC2
34glycogen43 249.2PSG2, CDH1, CDH2, KRT7, CEACAM5, VIM
35glucose438.2MUC2, CDH2, KRT7, PSG2, CEACAM5, MUC5AC
36mucicarmine438.2KRT20, KRT7, CEACAM7, CEACAM5, VIM
37oligonucleotide438.1CDH2, VIM, MUC2, MUC5AC, TP53, APC
38doxorubicin43 49 1210.0TP53, CEACAM5, KRT20, PSG2, VIM, CTNNB1
39serine437.9CTNNB1, CDH1, KRAS, CDH2, MUC2, MUC5AC
40butyrate437.8TP53, CDH1, VIM, CDX2, CEACAM7, KRAS
41hematoxylin437.7VIM, MUC2, MUC5AC, CEACAM5, PSG2, KRT7
42testosterone43 59 24 1210.7KRT7, APC, VIM, MUC5AC, CTNNB1, CDH2
435fluorouracil437.5TP53, MUC2, MUC5AC, CEACAM5, CEACAM7, PSG2
44b 723437.4CDH2, CDH1, KRT20, VIM, CEACAM5, KRT7
45retinoic acid43 248.1MUC2, CEACAM7, VIM, KRAS, KRT7, CDH1
46vegf437.1KRT20, TP53, CTNNB1, CEACAM5, PSG2, KRAS
47tyrosine437.0CTNNB1, APC, KRT20, CDH2, MUC5AC, CEACAM5
48paraffin435.8KRT7, KRAS, PSG2, CEACAM5, MUC5AC, MUC6
49progesterone43 28 59 24 129.6CTNNB1, CDH2, CDH1, CDX2, KRT20, KRT7
50estrogen435.1KRAS, CTNNB1, CDH1, CDX2, KRT20, KRT7

GO Terms for genes affiliated with Pseudomyxoma Peritonei

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Cellular components related to Pseudomyxoma Peritonei according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:00308779.9CTNNB1, APC
2fascia adherensGO:00059169.9CTNNB1, CDH2
3catenin complexGO:00163429.7CDH1, CDH2, CTNNB1
4lateral plasma membraneGO:00163289.7CTNNB1, CDH1, APC
5cell-cell adherens junctionGO:00059139.5APC, CDH1, CDH2, CTNNB1
6lamellipodiumGO:00300279.5CTNNB1, CDH2, APC
7Golgi lumenGO:00057969.3MUC5AC, MUC6, MUC5B, MUC2, F2
8basolateral plasma membraneGO:00163239.3CTNNB1, CDH1, CEACAM5
9intermediate filamentGO:00058828.9VIM, KRT7, KRT20
10extracellular regionGO:00055768.4F2, MUC5B, MUC6, REG4, PSG2, CDH1

Biological processes related to Pseudomyxoma Peritonei according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1maintenance of gastrointestinal epitheliumGO:003027710.1MUC2, MUC6
2regulation of protein localization to cell surfaceGO:0200000810.1CDH1, CTNNB1
3cellular response to indole-3-methanolGO:007168110.0CDH1, CTNNB1
4canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:004433610.0APC, CTNNB1
5striated muscle cell differentiationGO:005114610.0CDH2, KRAS
6proximal/distal pattern formationGO:00099549.8CTNNB1, APC
7negative regulation of canonical Wnt signaling pathwayGO:00900909.8CDH2, CDH1, APC
8T cell differentiation in thymusGO:00330779.7CTNNB1, TP53, APC
9O-glycan processingGO:00162669.7MUC2, MUC5B, MUC6, MUC5AC
10trophectodermal cell differentiationGO:00018299.7CDH1, CDX2
11cell migrationGO:00164779.6APC, PSG2, CDH2
12cellular component disassembly involved in execution phase of apoptosisGO:00069219.5CTNNB1, CDH1, VIM, APC
13intermediate filament organizationGO:00451099.4VIM, KRT20
14post-translational protein modificationGO:00436879.4F2, MUC2, MUC5B, MUC6, MUC5AC
15cellular protein metabolic processGO:00442679.3F2, MUC2, MUC5B, MUC6, MUC5AC
16apoptotic processGO:00069158.3APC, TP53, VIM, KRT20, CDH1, CTNNB1

Molecular functions related to Pseudomyxoma Peritonei according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alpha-catenin bindingGO:00452949.8CTNNB1, CDH2
2gamma-catenin bindingGO:00452959.7APC, CDH1, CDH2
3beta-catenin bindingGO:00080139.4CDH2, CDH1, APC
4protein phosphatase bindingGO:00199039.3CTNNB1, CDH2, CDH1, TP53
5protein bindingGO:00055156.3F2, APC, TP53, VIM, MUC2, MUC5B

Products for genes affiliated with Pseudomyxoma Peritonei

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Sources for Pseudomyxoma Peritonei

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet