PMP
MCID: PSD007
MIFTS: 62

Pseudomyxoma Peritonei (PMP) malady

Cancer diseases category

Summaries for Pseudomyxoma Peritonei

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Pseudomyxoma peritonei is a tumor that most often begins in the appendix.  as the tumor grows, tumor cells may spread into the peritoneal cavity and land on other nearby organs (such as the ovaries or intestines), sometimes forming additional tumors on the surface of these organs.  pseudomyxoma peritonei is extremely unlikely to grow into these organs (to become invasive) or spread to more distant parts of the body (metastasize); therefore, it is not usually thought of as a malignant tumor.  it is rare, occurring in approximately two out of a million people, and women are affected two to three times more frequently than men.  the first symptoms of pseudomyxoma peritonei are an increase in the size of the belly, appendicitis, or the finding of a mass on the ovary during medical imaging tests.   last updated: 9/27/2011

MalaCards: Pseudomyxoma Peritonei, also known as PMP, is related to peritonitis and adenocarcinoma, and has symptoms including estomach/gastric neoplasm/tumor/carcinoma/cancer, peritoneal diseases and anomalies of the abdominal wall. An important gene associated with Pseudomyxoma Peritonei is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Asparagine N-linked glycosylation and Mucin expression in CF via IL-6, IL-17 signaling pathways. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include appendix, ovary and colon, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Wikipedia:63 Pseudomyxoma peritonea is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that... more...

Aliases & Classifications for Pseudomyxoma Peritonei

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
pseudomyxoma peritonei:
Age of onset: Adulthood; Age of death: Any age


Aliases & Descriptions:

pseudomyxoma peritonei 8 42 10 44 48 60
pmp 42 48
syndrome of pseudomyxoma peritonei 42
gelatinous ascites 48
mucinous ascites 8
adenomucinosis 48


External Ids:

Disease Ontology8 DOID:3559
NCIt39 C3345
MeSH34 D011553
MESH via Orphanet35 D011553
ICD10 via Orphanet26 C78.6
SNOMED-CT via Orphanet57 112679004, 307601000
UMLS via Orphanet61 C0033822

Related Diseases for Pseudomyxoma Peritonei

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17GeneCards, 18GeneDecks
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Diseases related to Pseudomyxoma Peritonei via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.3F2
2adenocarcinoma31.2TP53, CEACAM5, CEACAM7, KRT20, KRT7, KRAS
3cystadenocarcinoma31.1CEACAM5, MUC5AC, MUC2
4mucinous cystadenocarcinoma31.0CEACAM7, KRT20, KRT7
5cystadenoma30.8KRT7, KRAS
6endometriosis30.7CDH2, PSG2
7hepatitis30.4KRAS, F2
8papillary carcinoma30.4KRT20, KRT7, CDH1, MUC2
9stomach cancer30.4KRAS, APC
10adenoma30.4TP53, CEACAM5, CEACAM7, KRT20, KRT7, KRAS
11pancreatitis30.2KRAS
12intestinal neoplasm30.2APC
13cervical cancer30.2TP53, CEACAM7, KRAS, PSG2
14colon adenocarcinoma30.2CEACAM5, CEACAM7, KRT20, KRAS, CDH1, MUC5AC
15ovarian cancer30.2TP53, KRT7, KRAS, CDH1, CDH2, PSG2
16malignant mesothelioma30.2CEACAM5, KRT20, KRT7, CDH1, CDH2, VIM
17lung adenocarcinoma30.2TP53, CEACAM5, CEACAM7, KRT20, KRT7, KRAS
18colorectal cancer30.2TP53, CEACAM5, CEACAM7, KRT20, KRT7, KRAS
19breast cancer30.2TP53, CEACAM5, CEACAM7, KRT7, KRAS, CDX2
20melanoma29.9TP53, CEACAM7, KRAS, CDX2, CDH1, CDH2
21mucinous adenocarcinoma10.8
22mucocele of appendix10.7
23mature teratoma10.6
24appendiceal neoplasm10.6
25appendix adenocarcinoma10.6
26cystic teratoma10.6
27ovarian cystic teratoma10.5
28appendix mucinous cystadenocarcinoma10.4
29ovarian cystadenocarcinoma10.4
30ovarian mucinous cystadenocarcinoma10.3
31intestinal obstruction10.3
32ovarian mucinous neoplasm10.3
33neurofibromatosis10.2
34acute pancreatitis10.2
35malignant peritoneal mesothelioma10.2
36colloid carcinoma of the pancreas10.2
37melioidosis10.2
38acromegaly10.2
39appendicitis10.2
40infertility10.2
41cecum adenocarcinoma10.2
42renal pelvis adenocarcinoma10.2
43colon mucinous adenocarcinoma10.2
44abdominal tuberculosis10.2
45bile duct carcinoma10.2
46cervicitis10.2
47dermatomyositis10.2
48hyperglycemia10.2
49mature teratoma of the ovary10.2
50ovarian cyst10.2

Graphical network of the top 20 diseases related to Pseudomyxoma Peritonei:



Diseases related to pseudomyxoma peritonei

Clinical Features for Pseudomyxoma Peritonei

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48Orphanet
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Symptoms:

48 (show all 19)
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • peritoneal diseases
  • anomalies of the abdominal wall
  • lymphadenopathy/polyadenopathies
  • pancreatic/pancreas neoplasm/tumor/carcinoma/cancer
  • constipation
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • early death/lethality
  • ascitis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • herniae
  • acute abdominal pain/colic
  • intestinal obstruction/ileus
  • colon neoplasm/tumor/carcinoma/cancer
  • inflammatory intestinal disease
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • digestive neoplasm/tumor/carcinoma/cancer
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Pseudomyxoma Peritonei

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pseudomyxoma Peritonei

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Anatomical Context for Pseudomyxoma Peritonei

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32MalaCards
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MalaCards organs/tissues related to Pseudomyxoma Peritonei:

32
Appendix, Ovary, Colon, Testes, Small intestine, Pancreas, Lung, Breast, Spleen, Skin, Liver, Kidney

Animal Models for Pseudomyxoma Peritonei or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pseudomyxoma Peritonei:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8APC, MUC2, CDH1, CDX2, KRAS, TP53
2MP:00053768.6MUC2, MUC5AC, CDH2, CDX2, F2
3MP:00053818.4TP53, APC, MUC2, MUC5AC, CDH1, CDX2
4MP:00053808.1VIM, APC, CDH2, CDH1, CDX2, F2
5MP:00053857.9VIM, APC, MUC2, CDH2, CDH1, CDX2
6MP:00053787.8APC, MUC2, CDH2, CDH1, CDX2, F2
7MP:00053847.4VIM, APC, MUC2, CDH2, CDH1, CDX2

Publications for Pseudomyxoma Peritonei

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50PubMed
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Articles related to Pseudomyxoma Peritonei:

(show top 50)    (show all 491)
idTitleAuthorsYear
1
Aggressive pseudomyxoma peritonei: a case report with an unusual clinical presentation. (24324903)
2013
2
Pseudomyxoma peritonei: a rare cause of oliguric acute kidney injury. (24010072)
2013
3
Melioidosis presenting as pseudomyxoma peritonei: yet another pretense of the great mimicker: an unreported entity. (23965152)
2013
4
The influence of tumor cell entrapment phenomenon on the natural history of Pseudomyxoma peritonei syndrome. (22469712)
2012
5
Identifying prognostic factors in Japanese women with pseudomyxoma peritonei: a retrospective clinico-pathological study of the Tohoku Gynecologic Cancer Unit. (21263209)
2011
6
Determining the association between preoperative computed tomography findings and postoperative outcomes after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei. (21207170)
2011
7
Pseudomyxoma peritonei presenting as recurrent rectal cancer: a preventable condition? (21120570)
2011
8
Operative findings, early complications, and long-term survival in 456 patients with pseudomyxoma peritonei syndrome of appendiceal origin. (21304299)
2011
9
Pseudomyxoma peritonei presenting with inguinal hernia. (21991881)
2011
10
A case of splenic low-grade mucinous cystadenocarcinoma resulting in pseudomyxoma peritonei. (21267701)
2010
11
Pseudomyxoma peritonei. (23133297)
2010
12
Ovarian cystadenocarcinoma and pseudomyxoma peritonei. (22753161)
2010
13
Tailgut cyst, an unusual cause of pseudomyxoma peritonei. (19856666)
2009
14
Mucinous adenocarcinoma of the appendix presenting with atypical symptomatology and presence of pseudomyxoma peritonei: a case report. (20062726)
2009
15
Re: An evidence-based approach: Sugarbaker protocol and pseudomyxoma peritonei of appendiceal origin. (18959716)
2008
16
Ovarian mucinous tumor arising in mature cystic teratoma associated with pseudomyxoma peritonei: a case with possible respiratory epithelial differentiation. (18156973)
2008
17
Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. (17524597)
2008
18
Mucinous ovarian tumors associated with pseudomyxoma peritonei of adenomucinosis type: immunohistochemical evidence that they are secondary tumors. (17511804)
2008
19
Pseudomyxoma peritonei secondary to epithelial appendicular neoplasms. Experience in a non-specialised centre. (18055329)
2007
20
Pseudomyxoma peritonei and mucinous pyometral fluid arising from an ovarian borderline mucinous tumor: case report. (17479681)
2007
21
Experimental models and questions in basic science research for pseudomyxoma peritonei. (17506254)
2007
22
A specific cadherin phenotype may characterise the disseminating yet non-metastatic behaviour of pseudomyxoma peritonei. (17031402)
2006
23
Ovarian mucinous tumour arising in mature cystic teratoma and associated with pseudomyxoma peritonei: report of two cases and comparison with ovarian involvement by low-grade appendiceal mucinous tumour. (17393980)
2006
24
Elevated tumour markers prior to complete tumour removal in patients with pseudomyxoma peritonei predict early recurrence. (15932563)
2005
25
Images in clinical medicine. Pseudomyxoma peritonei. (15071141)
2004
26
A case of pseudomyxoma peritonei with a unique palliative therapy. (14617486)
2003
27
Successful treatment of pseudomyxoma peritonei with intraperitoneal 10 per cent dextrose, sizofiran and cisplatin. (12521714)
2002
28
The subpyloric space: an important surgical and radiologic feature in pseudomyxoma peritonei. (12099657)
2002
29
A rare case of pseudomyxoma peritonei presenting an unusual inguinal hernia and splenic metastasis. (11446896)
2001
30
Extensive surgical cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in patients with pseudomyxoma peritonei. (11260116)
2001
31
Histopathologic analysis in 46 patients with pseudomyxoma peritonei syndrome: failure versus success with a second-look operation. (11266521)
2001
32
Ultrasonic dissection for pseudomyxoma peritonei: debulking, not cytoreduction. (11052529)
2000
33
MR enteroclysis: evaluation of small-bowel obstruction in a patient with pseudomyxoma peritonei. (10701610)
2000
34
Mucinous epithelial cysts of the spleen associated with pseudomyxoma peritonei. (10583579)
1999
35
Ultrasound imaging of pseudomyxoma peritonei with numerous vesicles in ascitic fluid. (10380313)
1999
36
Cytologic diagnosis of pseudomyxoma peritonei: common and uncommon causes. (8834070)
1996
37
A clinical study on pseudomyxoma peritonei. (7542493)
1995
38
Endometriosis with myxoid change. A case simulating pseudomyxoma peritonei. (8037300)
1994
39
Test and teach. Number Seventy-six. Diagnosis: Pseudomyxoma peritonei arising from appendical cystadenocarcinoma. (7991284)
1994
40
Pseudomyxoma peritonei. (8211593)
1993
41
Appendiceal mucoceles and pseudomyxoma peritonei. (1440166)
1992
42
Mucinous cystadenocarcinoma of the appendix with pseudomyxoma peritonei presenting as total uterine prolapse. A case report. (1548633)
1992
43
Obstructive nephropathy due to pseudomyxoma peritonei and its management by cystic obliteration and urinary diversion. (2057120)
1991
44
Role of surgery in the treatment of pseudomyxoma peritonei. (2342004)
1990
45
Primary mucinous cystadenocarcinoma of the appendix with pseudomyxoma peritonei manifested as a splenic mass. (2548288)
1989
46
Sonographic findings in a patient with pseudomyxoma peritonei. (6294143)
1982
47
The radiology corner. Pseudomyxoma peritonei, clinical and radiographic features. (607802)
1977
48
Pseudomyxoma peritonei arising from a mucinous adenocarcinoma of the sigmoid colon. (4750836)
1973
49
Pseudomyxoma peritonei. (4185408)
1969
50
Bluish translucent umbilical lesions of pseudomyxoma peritonei. (6046394)
1967

Genetic Variations for Pseudomyxoma Peritonei

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Expression for genes affiliated with Pseudomyxoma Peritonei

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pseudomyxoma Peritonei

Search GEO for disease gene expression data for Pseudomyxoma Peritonei.

Pathways for genes affiliated with Pseudomyxoma Peritonei

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53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology
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Compounds for genes affiliated with Pseudomyxoma Peritonei

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44Novoseek, 2BitterDB, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Pseudomyxoma Peritonei according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5CEACAM7
2butyrate4410.2CDX2, CEACAM7
3aristolochic acid44 210.9TP53, CDH1, VIM
45-methylcytosine44 2410.9TP53, CDH1, APC
5dicoumarol449.8MUC5AC, F2, TP53
6sulindac44 1110.7TP53, APC, CDH1
7o6-methylguanine449.7KRAS, TP53, APC, CDH1
8nocodazole44 1110.6TP53, CDH1, APC, VIM
9adriamycin449.5CEACAM5, PSG2, VIM
10vitamin d449.4VIM, KRAS, CDX2, APC, CDH1
11leucovorin44 49 1111.4CEACAM5, KRAS, PSG2
12sb 20358044 5910.3VIM, MUC2, MUC5AC, CDH1, TP53
13p002449.2CEACAM5, PSG2, KRAS, CDH1
14carbohydrates449.2MUC2, CEACAM5, MUC5AC, CDH1
15proline449.2TP53, CDH1, MUC5AC, MUC2, VIM
16irinotecan44 49 1111.2KRAS, CEACAM5, TP53, CDH1
17cytosine44 2410.2CDH1, APC, PSG2, CEACAM5
18sialic acid449.2KRT7, CEACAM5, CDH2
19formaldehyde44 2410.1PSG2, CDH1, KRT7, VIM, KRT20
20retinoid449.1TP53, KRT7, CDH1, MUC5AC, VIM
21hydroxyapatite449.1CDH1, CEACAM5, VIM
22methotrexate44 49 1111.1KRT7, F2, CDH1, MUC5AC, MUC2, VIM
23oxaliplatin44 49 1111.0KRAS, CEACAM5, TP53
24latex448.9CDH2, PSG2, CEACAM5, CDH1
25gefitinib44 49 1110.8KRAS, VIM, CEACAM5, CDH1, CEACAM7
26crcs448.7APC, MUC2, CDH1, KRAS, TP53, CEACAM5
27hyaluronic acid44 249.7KRT20, CEACAM5, F2, CDH1, VIM
28lactate448.7CEACAM5, PSG2, F2, VIM, CDH1
29phosphatidylinositol448.6APC, CEACAM5, KRAS, CDH1, MUC5AC
30mucicarmine448.4CEACAM5, CEACAM7, KRT7, VIM, KRT20
31polysaccharide448.4CEACAM5, KRT7, MUC5AC, MUC6, CDH2
32doxorubicin44 49 1110.4KRT20, CEACAM5, VIM, PSG2, TP53, CDH1
335-aza-2deoxycytidine448.3CDH1, VIM, APC, KRT7, TP53, MUC2
34oligonucleotide448.2VIM, MUC6, MUC2, MUC5AC, CDH2, APC
35thymidine44 249.1PSG2, CDX2, TP53, CEACAM5, CEACAM7
36testosterone44 59 11 2411.1KRT20, VIM, KRT7, CDH2, MUC5AC, APC
37cysteine448.0VIM, CDH1, MUC2, CDH2, MUC5AC, CDX2
38glycogen44 249.0KRT7, CDH1, CDH2, VIM, PSG2, APC
39serine448.0F2, CDH1, KRAS, TP53, CDH2, MUC5AC
40glucose447.9KRT7, CDH2, MUC5AC, APC, PSG2, MUC2
41hematoxylin447.8CEACAM5, CDH1, KRT20, KRT7, MUC5AC, MUC2
425fluorouracil447.8MUC2, MUC6, KRAS, CEACAM7, CEACAM5, TP53
43lipid447.7KRT7, VIM, CDH2, APC, PSG2, CEACAM5
44retinoic acid44 248.5TP53, MUC2, VIM, APC, MUC5AC, CDH2
45b 723447.4KRT7, CEACAM5, VIM, PSG2, CDH2, CDH1
46vegf447.3CEACAM5, KRT20, KRT7, PSG2, TP53, VIM
47tyrosine447.1CDH1, KRAS, KRT7, KRT20, CEACAM5, APC
48calcium44 49 11 2410.0MUC2, MUC6, MUC5AC, CDH1, CDX2, REG4
49paraffin445.9CEACAM5, MUC6, TP53, KRT20, KRT7, KRAS
50progesterone44 59 28 11 249.9APC, MUC2, MUC6, MUC5AC, CDH2, CDH1

GO Terms for genes affiliated with Pseudomyxoma Peritonei

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16Gene Ontology
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Cellular components related to Pseudomyxoma Peritonei according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.4CDH1, CDH2
2cell-cell adherens junctionGO:0059139.2APC, CDH2, CDH1
3intermediate filamentGO:0058829.2KRT20, KRT7, VIM
4Golgi lumenGO:0057969.1F2, MUC5B, MUC5AC, MUC6, MUC2

Biological processes related to Pseudomyxoma Peritonei according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.7KRT20, VIM
2cellular component disassembly involved in execution phase of apoptosisGO:0069219.6VIM, APC, CDH1
3O-glycan processingGO:0162669.5MUC5B, MUC5AC, MUC6, MUC2
4striated muscle cell differentiationGO:0511469.4KRAS, CDH2
5post-translational protein modificationGO:0436879.2MUC2, MUC6, MUC5AC, MUC5B, F2
6cellular protein metabolic processGO:0442679.0MUC2, MUC6, MUC5AC, MUC5B, F2

Molecular functions related to Pseudomyxoma Peritonei according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:0452959.4CDH1, CDH2, APC
2extracellular matrix structural constituentGO:0052019.3MUC6, MUC5AC, MUC5B
3beta-catenin bindingGO:0080139.2CDH1, CDH2, APC
4protein bindingGO:0055156.6APC, MUC2, MUC5B, CDH2, CDH1, MCCC1

Products for genes affiliated with Pseudomyxoma Peritonei

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Sources for Pseudomyxoma Peritonei

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet