PMP
MCID: PSD007
MIFTS: 58

Pseudomyxoma Peritonei (PMP) malady

Cancer category

Summaries for Pseudomyxoma Peritonei

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Pseudomyxoma peritonei is a tumor that most often begins in the appendix.  as the tumor grows, tumor cells may spread into the peritoneal cavity and land on other nearby organs (such as the ovaries or intestines), sometimes forming additional tumors on the surface of these organs.  pseudomyxoma peritonei is extremely unlikely to grow into these organs (to become invasive) or spread to more distant parts of the body (metastasize); therefore, it is not usually thought of as a malignant tumor.  it is rare, occurring in approximately two out of a million people, and women are affected two to three times more frequently than men.  the first symptoms of pseudomyxoma peritonei are an increase in the size of the belly, appendicitis, or the finding of a mass on the ovary during medical imaging tests.   last updated: 9/27/2011

MalaCards: Pseudomyxoma Peritonei, also known as PMP, is related to adenocarcinoma and mucinous cystadenocarcinoma, and has symptoms including anomalies of the abdominal wall, ascitis and peritoneal diseases. An important gene associated with Pseudomyxoma Peritonei is MUC2 (mucin 2, oligomeric mucus/gel-forming), and among its related pathways are Asparagine N-linked glycosylation and Mucin expression in CF via IL-6, IL-17 signaling pathways. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include whole blood, spleen and small intestine, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Wikipedia:64 Pseudomyxoma peritonea is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that... more...

Aliases & Classifications for Pseudomyxoma Peritonei

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
pseudomyxoma peritonei:
Age of onset: Adulthood; Age of death: Any age


Aliases & Descriptions:

pseudomyxoma peritonei 8 43 10 45 49 61
pmp 43 49
syndrome of pseudomyxoma peritonei 43
gelatinous ascites 49
mucinous ascites 8
adenomucinosis 49


External Ids:

Disease Ontology8 DOID:3559
NCIt40 C3345
MeSH35 D011553
MESH via Orphanet36 D011553
ICD10 via Orphanet26 C78.6
SNOMED-CT via Orphanet58 112679004, 307601000
UMLS via Orphanet62 C0033822

Related Diseases for Pseudomyxoma Peritonei

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pseudomyxoma Peritonei via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2TP53, CEACAM5, CEACAM7, KRT20, KRT7, KRAS
2mucinous cystadenocarcinoma31.1CEACAM7, KRT20, KRT7
3teratoma31.0KRT7
4cystadenoma30.9KRT7, KRAS
5papillary carcinoma30.5KRT20, KRT7, CDH1, MUC2
6stomach cancer30.5KRAS, APC
7adenoma30.4TP53, CEACAM5, CEACAM7, KRT20, KRT7, KRAS
8colorectal cancer30.2TP53, CEACAM5, CEACAM7, KRT20, KRT7, KRAS
9mucinous adenocarcinoma10.8
10appendiceal neoplasm10.7
11appendix adenocarcinoma10.6
12ovarian cystic teratoma10.6
13urachal cyst10.5
14appendix mucinous cystadenocarcinoma10.4
15urachal adenocarcinoma10.4
16peritoneal carcinoma10.4
17ovarian mucinous cystadenocarcinoma10.4
18n syndrome10.4
19gelatinous ascites10.4
20neurofibromatosis10.2
21acute pancreatitis10.2
22malignant peritoneal mesothelioma10.2
23plexiform neurofibroma10.2
24melioidosis10.2
25malignant ovarian cyst10.2
26acromegaly10.2
27infertility10.2
28cecum adenocarcinoma10.2
29renal pelvis adenocarcinoma10.2
30colon mucinous adenocarcinoma10.2
31abdominal tuberculosis10.2
32bile duct carcinoma10.2
33tuberculosis10.2
34cerebellar degeneration10.2
35paraneoplastic cerebellar degeneration10.2
36sacrococcygeal teratoma10.2
37adrenoleukodystrophy10.0
38sensory peripheral neuropathy10.0
39motor peripheral neuropathy10.0
40endometrial mucinous adenocarcinoma10.0
41ampulla of vater carcinoma10.0MUC2
42esophagitis10.0CDX2
43renal oncocytoma10.0KRT7
44mixed cell type cancer10.0KRT7
45pancreatitis10.0KRAS
46inverted papilloma10.0KRT20
47biliary tract cancer10.0PSG2
48peptic ulcer10.0MUC5AC
49pleurisy10.0PSG2
50thymic carcinoma10.0KRT7

Graphical network of the top 20 diseases related to Pseudomyxoma Peritonei:



Diseases related to pseudomyxoma peritonei

Clinical Features for Pseudomyxoma Peritonei

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 19)
  • anomalies of the abdominal wall
  • ascitis
  • peritoneal diseases
  • inflammatory intestinal disease
  • herniae
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • constipation
  • intestinal obstruction/ileus
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • lymphadenopathy/polyadenopathies
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • digestive neoplasm/tumor/carcinoma/cancer
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • colon neoplasm/tumor/carcinoma/cancer
  • pancreatic/pancreas neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration

Drugs & Therapeutics for Pseudomyxoma Peritonei

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pseudomyxoma Peritonei

Drug clinical trials:

Search ClinicalTrials for Pseudomyxoma Peritonei

Search NIH Clinical Center for Pseudomyxoma Peritonei

Search CenterWatch for Pseudomyxoma Peritonei

Genetic Tests for Pseudomyxoma Peritonei

Anatomical Context for Pseudomyxoma Peritonei

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pseudomyxoma Peritonei:

33
Whole blood, Spleen, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Breast, Skin, Ovary, Appendix

Animal Models for Pseudomyxoma Peritonei or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pseudomyxoma Peritonei:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8APC, MUC2, CDH1, CDX2, KRAS, TP53
2MP:00053768.6MUC2, MUC5AC, CDH2, CDX2, F2
3MP:00053818.4TP53, APC, MUC2, MUC5AC, CDH1, CDX2
4MP:00053808.1VIM, APC, CDH2, CDH1, CDX2, F2
5MP:00053857.9VIM, APC, MUC2, CDH2, CDH1, CDX2
6MP:00053787.8APC, MUC2, CDH2, CDH1, CDX2, F2
7MP:00053847.4VIM, APC, MUC2, CDH2, CDH1, CDX2

Publications for Pseudomyxoma Peritonei

Sources:
51PubMed
See all sources

Articles related to Pseudomyxoma Peritonei:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis. (23199549)
2013
2
Treatment of pseudomyxoma peritonei with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): a single center experience. (24193289)
2013
3
Feasibility of radical cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendiceal origin. (23963027)
2013
4
Improved survival of patients with pseudomyxoma peritonei receiving intraperitoneal chemotherapy with cytoreductive surgery: a systematic review and meta-analysis. (23490141)
2013
5
Recurrent Incisional Hernia due to Pseudomyxoma Peritonei. (21629816)
2011
6
On or in the liver? Two cases with diffuse pseudomyxoma peritonei and synchronous hepatic pathology. (21249511)
2011
7
Pseudomyxoma peritonei originating from colorectal cancer during pregnancy. (21114581)
2011
8
Application of advanced multimodality care to pseudomyxoma peritonei patient: report of first patient treated at a tertiary center. (22693376)
2010
9
Mucinous adenocarcinoma of the urachal remnant with pseudomyxoma peritonei. (20535705)
2010
10
Laparoscopic mucin removal in patients with pseudomyxoma peritonei. (19660216)
2009
11
Management of appendiceal pseudomyxoma peritonei diagnosed during pregnancy. (19454019)
2009
12
Blood transfusion therapy for massive hemorrhage associated with scheduled peritonectomy for pseudomyxoma peritonei and peritoneal dissemination]. (19364003)
2009
13
One of the most difficult management problems in surgery is pseudomyxoma peritonei. Foreword. (18590841)
2008
14
Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei. (18344868)
2008
15
An evidence-based approach: Sugarbaker protocol and pseudomyxoma peritonei of appendiceal origin. (18380718)
2008
16
Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin/fluorouracil/leucovorin (FOLFOX4). (19014441)
2008
17
Pseudomyxoma peritonei presenting with femoral hernias and peritonitis. (17508254)
2007
18
Intraperitoneal hyperthermia in the management of pseudomyxoma peritonei. (17419229)
2007
19
Toxicity and mortality of cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei--a report of 103 procedures. (16303281)
2006
20
Cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei from appendiceal mucinous neoplasms. (16838392)
2006
21
Pseudomyxoma peritonei from mucinous adenocarcinoma of the urachus. (17050882)
2006
22
Pseudomyxoma peritonei: a clinicopathologic analysis and follow-up of 21 patients. (15966210)
2005
23
Mucinous tumors arising in ovarian mature cystic teratomas: relationship to the clinical syndrome of pseudomyxoma peritonei. (12717249)
2003
24
Image of the month: pseudomyxoma peritonei. (12806604)
2003
25
Pseudomyxoma peritonei. (11854707)
2002
26
Cytoreductive surgery and perioperative intraperitoneal chemotherapy as a curative approach to pseudomyxoma peritonei syndrome. (11693816)
2001
27
Patients with pseudomyxoma peritonei associated with disseminated peritoneal adenomucinosis have a significantly more favorable prognosis than patients with peritoneal mucinous carcinomatosis. (11443613)
2001
28
Extraperitoneal presentation of pseudomyxoma peritonei as a scrotal mass: case report and review of the literature. (17322685)
2000
29
The coexistence of low-grade mucinous neoplasms of the appendix and appendiceal diverticula: a possible role in the pathogenesis of pseudomyxoma peritonei. (10824920)
2000
30
Immunohistochemical evidence supporting the appendiceal origin of pseudomyxoma peritonei in women. (8986525)
1997
31
Pulmonary metastases in pseudomyxoma peritonei syndrome. (9386716)
1997
32
Mucinous adenocarcinoma arising in a giant urachal cyst associated with pseudomyxoma peritonei and stromal osseous metaplasia. (9234391)
1997
33
Failed treatment of pseudomyxoma peritonei (PMP) with intraperitoneal interferon alpha. (9005155)
1996
34
Clinical determinants of treatment failure in patients with pseudomyxoma peritonei. (8834580)
1996
35
Detection of pseudomyxoma peritonei by radioimmunohistochemistry and radioimmunoscintigraphy. (10851513)
1996
36
Appendiceal mucinous cystadenoma associated with pseudomyxoma peritonei and multicystic peritoneal mesothelioma: report of a case. (8520171)
1995
37
Pseudomyxoma peritonei. (10887034)
1995
38
Treatment of pseudomyxoma peritonei in a geriatric patient population. (7844982)
1995
39
Pseudomyxoma peritonei. A cancer whose biology is characterized by a redistribution phenomenon. (8129480)
1994
40
A role for dextran in pseudomyxoma peritonei? (1376399)
1992
41
The management of pseudomyxoma peritonei. (2208015)
1990
42
Pseudomyxoma peritonei. A report of three cases. (2561123)
1989
43
Pseudomyxoma peritonei presenting as a scrotal mass. (3352057)
1988
44
Pseudomyxoma peritonei--benign or malignant. (3758624)
1986
45
Biochemical identification of the mucus of pseudomyxoma peritonei as the basis for mucolytic treatment. (2430456)
1986
46
Successful treatment of pseudomyxoma peritonei of ovarian origin with cis-platinum, doxorubicin, and cyclophosphamide. (4054721)
1985
47
Histogenesis of pseudomyxoma peritonei. Review of 9 cases. (840463)
1977
48
The second-look procedure in the management of ovarian malignancies and pseudomyxoma peritonei. (13746378)
1961
49
Pseudomyxoma peritonei. (13655140)
1959
50
On the etiology of pseudomyxoma peritonei ex appendicitide. (13605911)
1958

Genetic Variations for Pseudomyxoma Peritonei

Expression for genes affiliated with Pseudomyxoma Peritonei

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pseudomyxoma Peritonei

Search GEO for disease gene expression data for Pseudomyxoma Peritonei.

Pathways for genes affiliated with Pseudomyxoma Peritonei

Sources:
54Reactome, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Pseudomyxoma Peritonei

Sources:
45Novoseek, 2BitterDB, 24HMDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Pseudomyxoma Peritonei according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5CEACAM7
2butyrate4510.2CDX2, CEACAM7
3aristolochic acid45 210.9VIM, CDH1, TP53
45-methylcytosine45 2410.9TP53, CDH1, APC
5dicoumarol459.8MUC5AC, F2, TP53
6sulindac45 1110.7TP53, CDH1, APC
7o6-methylguanine459.7APC, CDH1, KRAS, TP53
8nocodazole45 1110.6VIM, APC, CDH1, TP53
9adriamycin459.5CEACAM5, PSG2, VIM
10vitamin d459.4KRAS, CDX2, CDH1, APC, VIM
11leucovorin45 50 1111.4CEACAM5, KRAS, PSG2
12sb 20358045 6010.3VIM, MUC2, MUC5AC, CDH1, TP53
13p002459.2PSG2, CDH1, KRAS, CEACAM5
14carbohydrates459.2MUC2, MUC5AC, CDH1, CEACAM5
15proline459.2VIM, MUC2, MUC5AC, CDH1, TP53
16irinotecan45 50 1111.2CDH1, KRAS, CEACAM5, TP53
17cytosine45 2410.2CEACAM5, CDH1, PSG2, APC
18sialic acid459.2CEACAM5, KRT7, CDH2
19formaldehyde45 2410.1VIM, PSG2, CDH1, KRT7, KRT20
20retinoid459.1VIM, MUC5AC, CDH1, KRT7, TP53
21hydroxyapatite459.1CEACAM5, CDH1, VIM
22methotrexate45 50 1111.1VIM, MUC2, MUC5AC, CDH1, F2, KRT7
23oxaliplatin45 50 1111.0TP53, CEACAM5, KRAS
24latex458.9CEACAM5, CDH1, CDH2, PSG2
25gefitinib45 50 1110.8VIM, CDH1, KRAS, CEACAM7, CEACAM5
26crcs458.7APC, MUC2, CDH1, KRAS, CEACAM5, TP53
27hyaluronic acid45 249.7CEACAM5, KRT20, F2, CDH1, VIM
28lactate458.7VIM, PSG2, CDH1, F2, CEACAM5
29phosphatidylinositol458.6APC, MUC5AC, CDH1, KRAS, CEACAM5
30mucicarmine458.4VIM, KRT7, KRT20, CEACAM7, CEACAM5
31polysaccharide458.4MUC6, MUC5AC, CDH2, KRT7, CEACAM5
32doxorubicin45 50 1110.4VIM, PSG2, CDH1, KRT20, CEACAM5, TP53
335-aza-2deoxycytidine458.3VIM, APC, MUC2, CDH2, CDH1, CDX2
34oligonucleotide458.2VIM, APC, MUC2, MUC6, MUC5AC, CDH2
35thymidine45 249.1PSG2, CDX2, CEACAM7, CEACAM5, TP53
36testosterone45 60 11 2411.1VIM, APC, MUC5AC, CDH2, CDH1, KRT7
37cysteine458.0VIM, MUC2, MUC5AC, CDH2, CDH1, CDX2
38glycogen45 249.0VIM, APC, PSG2, CDH2, CDH1, KRT7
39serine458.0VIM, APC, MUC2, MUC5AC, CDH2, CDH1
40glucose457.9APC, PSG2, MUC2, MUC5AC, CDH2, KRT7
41hematoxylin457.8CDH1, KRT7, KRT20, CEACAM5, MUC5AC, MUC2
425fluorouracil457.8PSG2, MUC2, MUC6, MUC5AC, CDH1, KRAS
43lipid457.7VIM, APC, PSG2, CDH2, KRAS, KRT7
44retinoic acid45 248.5VIM, APC, MUC2, MUC5AC, CDH2, CDH1
45b 723457.4VIM, PSG2, CDH2, CDH1, KRT7, KRT20
46vegf457.3VIM, PSG2, CDH2, CDH1, KRAS, KRT7
47tyrosine457.1APC, MUC5AC, CDH2, CDH1, CDX2, KRAS
48calcium45 50 11 2410.0APC, MUC2, MUC6, MUC5AC, CDH2, CDH1
49paraffin455.9CDH2, CDH1, CDX2, KRAS, KRT7, KRT20
50progesterone45 60 29 11 249.9VIM, APC, MUC2, MUC6, MUC5AC, CDH2

GO Terms for genes affiliated with Pseudomyxoma Peritonei

Sources:
16Gene Ontology
See all sources

Cellular components related to Pseudomyxoma Peritonei according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.4CDH1, CDH2
2cell-cell adherens junctionGO:0059139.2APC, CDH2, CDH1
3intermediate filamentGO:0058829.2KRT20, KRT7, VIM
4Golgi lumenGO:0057969.1F2, MUC5B, MUC5AC, MUC6, MUC2

Biological processes related to Pseudomyxoma Peritonei according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.7KRT20, VIM
2cellular component disassembly involved in execution phase of apoptosisGO:0069219.6VIM, APC, CDH1
3O-glycan processingGO:0162669.5MUC5B, MUC5AC, MUC6, MUC2
4striated muscle cell differentiationGO:0511469.4KRAS, CDH2
5post-translational protein modificationGO:0436879.2MUC2, MUC6, MUC5AC, MUC5B, F2
6cellular protein metabolic processGO:0442679.0MUC2, MUC6, MUC5AC, MUC5B, F2

Molecular functions related to Pseudomyxoma Peritonei according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:0452959.4CDH1, CDH2, APC
2extracellular matrix structural constituentGO:0052019.3MUC6, MUC5AC, MUC5B
3beta-catenin bindingGO:0080139.2CDH1, CDH2, APC
4protein bindingGO:0055156.6APC, MUC2, MUC5B, CDH2, CDH1, MCCC1

Products for genes affiliated with Pseudomyxoma Peritonei

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Sources for Pseudomyxoma Peritonei

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet