MCID: PSR002
MIFTS: 51

Psoriasis malady

Skin category

Summaries for Psoriasis

Sources:
43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people who have psoriasis also get a form of arthritis called psoriatic arthritis. a problem with your immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in your skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because your cells rise too fast. psoriasis can be hard to diagnose because it can look like other skin diseases. your doctor might need to look at a small skin sample under a microscope. psoriasis can last a long time, even a lifetime. symptoms come and go. things that make them worse include infections stress dry skin certain medicines psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medicines, and light therapy. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Psoriasis is related to arthritis and psoriatic arthritis. An important gene associated with Psoriasis is PSORS1C1 (psoriasis susceptibility 1 candidate 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The drugs anthralin and betamethasone and the compounds pge2 and allopurinol have been mentioned in the context of this disorder.

NIH Rare Diseases:43 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. the skin on the elbows, knees, scalp, back, face, palms and feet is most often affected, but other parts of the body can be affected as well. a problem with the immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in the skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because the cells rise too fast. although symptoms may come and go, for many, psoriasis is a lifelong condition. infections, stress, dry skin and certain medications may make symptoms worse. psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medications and light therapy. last updated: 2/12/2010

CDC:3 Psoriasis is a chronic, autoimmune skin disease that speeds up the growth cycle of skin cells.

Wikipedia:64 Psoriasis (pronounced /sɵˈraɪ.əsɨs/; from Greek ψωρίασις, meaning \"itching condition\" or... more...

Aliases & Classifications for Psoriasis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

psoriasis 8 43 20 22 10 45 34 61


External Ids:

Disease Ontology8 DOID:8893
ICD9CM27 696.5
ICD1025 L40, L40.9

Related Diseases for Psoriasis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Psoriasis:



Diseases related to psoriasis

Clinical Features for Psoriasis

Genetic Tests for Psoriasis

Sources:
20GeneTests, 22GTR
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Genetic tests related to Psoriasis:

id Genetic test Affiliating Genes
1 Psoriasis20 22

Anatomical Context for Psoriasis

Animal Models for Psoriasis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Psoriasis

Sources:
51PubMed
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Articles related to Psoriasis:

(show top 50)    (show all 2521)
idTitleAuthorsYear
1
Increased risk of diabetes mellitus in relation to the severity of psoriasis, concomitant medication, and comorbidity: A nationwide population-based cohort study. (24411084)
2014
2
Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: Results from the Italian Psocare Registry. (24355410)
2014
3
Cardiometabolic profile, clinical features, quality of life and treatment outcomes in patients with moderate-to-severe psoriasis and psoriatic arthritis. (24283931)
2013
4
Recalcitrant psoriasis responding to new bilogic drug: Ustekinumab. (24413873)
2013
5
Safety and Tolerability of Tumor Necrosis Factor-I+ Inhibitors in Psoriasis: A Narrative Review. (24281790)
2013
6
Adherence to ustekinumab in psoriasis patients. (24085042)
2013
7
Multiple keratoacanthomas developing in healing plaques of Psoriasis. (23984234)
2013
8
Liraglutide in combination with acitretin for severe recalcitrant psoriasis. (23834125)
2013
9
Undertreatment, treatment trends, and treatment dissatisfaction among patients with psoriasis and psoriatic arthritis in the United States: findings from the National Psoriasis Foundation surveys, 2003-2011. (23945732)
2013
10
Psoriasis and dyslipidemia: a population-based study analyzing the National Health and Nutrition Examination Survey (NHANES). (23909936)
2013
11
A 36-week retrospective open trial comparing the efficacy of biological therapies in nail psoriasis. (24119121)
2013
12
Long-term combination therapy of ustekinumab and dapsone in a patient with psoriasis and dermatitis herpetiformis Duhring. (22784106)
2012
13
A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case-control study. (21645569)
2011
14
Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis. (20506062)
2010
15
Ustekinumab for the treatment of psoriasis: review of three multicenter clinical trials. (20502723)
2010
16
Generalized pustular psoriasis in childhood. (20403118)
2010
17
Images in emergency medicine. Guttate psoriasis. (19303510)
2009
18
The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice. (19590497)
2009
19
Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (18643845)
2009
20
Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition. (17671512)
2008
21
Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. (18219280)
2008
22
Association between P478S polymorphism of the filaggrin gene and risk of psoriasis in a Chinese population in Taiwan. (18193244)
2008
23
Clinical relevance of nerve growth factor serum levels in patients with atopic dermatitis and psoriasis. (17579279)
2007
24
Adhesion of peripheral blood mononuclear cells and CD4+ T cells from patients with psoriasis to cultured endothelial cells via the interaction between lymphocyte function-associated antigen type 1 and intercellular adhesion molecule 1. (17596165)
2007
25
Psoriasis vulgaris and human leukocyte antigens. (17309450)
2007
26
The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese. (17314032)
2007
27
Cyclosporine resolves generalized pustular psoriasis of pregnancy. (17043209)
2006
28
Association of HLA-A, -B, -C genes and TNF microsatellite polymorphism with psoriasis vulgaris: a study of genetic risk in Brazilian patients. (17101473)
2006
29
The expression of p63 during epidermal remodeling in psoriasis. (15863843)
2005
30
Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS. (15855153)
2005
31
Genetic markers and psoriasis in three ethnic populations of Dagestan]. (16396458)
2005
32
Etanercept for the treatment of psoriasis and psoriatic arthritis. (15379775)
2004
33
Antisense oligonucleotide treatments for psoriasis. (14680470)
2004
34
Granulocyte colony-stimulating-factor-induced psoriasiform dermatitis resembles psoriasis with regard to abnormal cytokine expression and epidermal activation. (15186319)
2004
35
HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes. (14675183)
2003
36
CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis. (14634077)
2003
37
No associations of CTLA-4 and ICAM-1 polymorphisms with psoriasis in the Korean population. (14527743)
2003
38
Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients. (12505198)
2003
39
The interrelationship between sex, susceptibility factors, and outcome in ankylosing spondylitis and its associated disorders including inflammatory bowel disease, psoriasis, and iritis. (12966615)
2003
40
Histochemical analysis of macrophage migration inhibitory factor in psoriasis vulgaris. (12271361)
2002
41
Interleukin-10 promoter polymorphism in psoriasis. (11407990)
2001
42
Generalized pustular psoriasis following withdrawal of oral cyclosporin treatment for palmo-plantar pustulosis. (10233640)
1999
43
Tonsillitis and chronic psoriasis. (9563669)
1998
44
Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis. (9158158)
1997
45
Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. (8034808)
1994
46
Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: reduced expression of protein kinase C-beta II in psoriasis. (8409523)
1993
47
Induction of disseminated superficial actinic porokeratosis by phototherapy for psoriasis. (2007687)
1991
48
Basement membrane zone as a target for human neutrophil elastase in psoriasis. (1707254)
1990
49
"Cold" corneal abscess in psoriasis: a case report. (2628702)
1989
50
Conversion of carotene to vitamin A by sebaceous glands; interference in pityriasis rubra pilaris, ichthyosis, and psoriasis as shown by fluorescent microscopy. (13457425)
1957

Genetic Variations for Psoriasis

Expression for genes affiliated with Psoriasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psoriasis

Search GEO for disease gene expression data for Psoriasis.

Pathways for genes affiliated with Psoriasis

Sources:
52QIAGEN, 30KEGG
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Compounds for genes affiliated with Psoriasis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Psoriasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pge24511.1CCL2, AREG, IL17A, ALOX5AP
2allopurinol45 50 1112.9PSORS1C1, PSORS1C3, PSORS1C2
3actinomycin d4510.8CCL2, AREG, IL17A, ALOX5AP

GO Terms for genes affiliated with Psoriasis

Sources:
16Gene Ontology
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Biological processes related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:04567210.8IL17A, IL20

Products for genes affiliated with Psoriasis

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Sources for Psoriasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet