MCID: PSR002
MIFTS: 60

Psoriasis malady

Skin diseases category

Summaries for Psoriasis

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people who have psoriasis also get a form of arthritis called psoriatic arthritis. a problem with your immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in your skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because your cells rise too fast. psoriasis can be hard to diagnose because it can look like other skin diseases. your doctor might need to look at a small skin sample under a microscope. psoriasis can last a long time, even a lifetime. symptoms come and go. things that make them worse include infections stress dry skin certain medicines psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medicines, and light therapy. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Psoriasis is related to arthritis and psoriatic arthritis. An important gene associated with Psoriasis is PSORS1C1 (psoriasis susceptibility 1 candidate 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The drugs cyclosporine and hydroxyurea and the compounds pge2 and allopurinol have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

NIH Rare Diseases:42 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. the skin on the elbows, knees, scalp, back, face, palms and feet is most often affected, but other parts of the body can be affected as well. a problem with the immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in the skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because the cells rise too fast. although symptoms may come and go, for many, psoriasis is a lifelong condition. infections, stress, dry skin and certain medications may make symptoms worse. psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medications and light therapy. last updated: 2/12/2010

CDC:3 Psoriasis is a chronic, autoimmune skin disease that speeds up the growth cycle of skin cells.

Wikipedia:63 Psoriasis (pronounced /sɵˈraɪ.əsɨs/; from Greek ψωρίασις, meaning \"itching condition\" or... more...

Aliases & Classifications for Psoriasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

psoriasis 8 42 20 22 10 44 33 60


External Ids:

Disease Ontology8 DOID:8893
ICD9CM27 696.5
ICD1025 L40, L40.9

Related Diseases for Psoriasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Psoriasis:



Diseases related to psoriasis

Clinical Features for Psoriasis

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Genetic Tests for Psoriasis

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20GeneTests, 22GTR
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Genetic tests related to Psoriasis:

id Genetic test Affiliating Genes
1 Psoriasis20 22

Anatomical Context for Psoriasis

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32MalaCards
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MalaCards organs/tissues related to Psoriasis:

32
Skin, T cells, Endothelial, Monocytes, Liver, Thyroid, Testes, Bone, Lung, Heart, Tongue, Bone marrow, Kidney, Eye, Tonsil, Colon, Pituitary, Myeloid, B cells, Thymus

Animal Models for Psoriasis or affiliated genes

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Publications for Psoriasis

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Sources:
50PubMed
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Articles related to Psoriasis:

(show top 50)    (show all 2518)
idTitleAuthorsYear
1
Promising new treatments for psoriasis. (23935446)
2013
2
Development of a Disease-Specific Version of the EQ-5D-5L for Use in Patients Suffering from Psoriasis: Lessons Learned from a Feasibility Study in the UK. (24326169)
2013
3
Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk. (24005976)
2013
4
Item-level psychometric properties for a new patient-reported psoriasis symptom diary. (24041351)
2013
5
Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis. (23297015)
2013
6
Cancer-free survival of psoriasis patients treated with methotrexate and cyclosporine combination. (23944659)
2013
7
Impact of active and stable psoriasis on health-related quality of life: the PSO-LIFE study. (23958428)
2013
8
Association of the tumour necrosis factor-I+ polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis. (24252077)
2013
9
Improvement in aspects of sleep with etanercept and optional adjunctive topical therapy in patients with moderate-to-severe psoriasis: results from the PRISTINE trial. (23848989)
2013
10
Psoriasin: a novel marker linked obesity with psoriasis. (23151615)
2013
11
Follicular psoriasis. (24074364)
2013
12
Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to psoriasis in a Chinese population. (23846034)
2013
13
Management of psoriasis in pregnancy. (23914885)
2013
14
Equivalence and measurement properties of an electronic version of the Psoriasis Symptom Inventory. (24052326)
2013
15
Loss-of-function mutations in filaggrin gene associate with psoriasis vulgaris in Chinese population. (22407025)
2012
16
Methotrexate-induced liver cirrhosis in a patient of psoriasis. (23029724)
2012
17
Optic neuritis associated with tumor necrosis factor-alfa antagonists for the treatment of psoriasis. (23158640)
2012
18
Association between T-lymphocyte regulatory gene CTLA4 single nucleotide polymorphism at position 49 in exon 1 and HLA-DRB1*08 in Japanese patients with psoriasis vulgaris. (21316924)
2011
19
An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population. (21128207)
2010
20
The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS. (20377629)
2010
21
Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. (19266104)
2009
22
Childhood generalized pustular psoriasis treated by preprandial ciclosporin administration: serum cytokine pattern during the course of the disease. (20055828)
2009
23
Amelioration of psoriasis by anti-TNF-alpha RNAi in the xenograft transplantation model. (19568223)
2009
24
Investigation of +405 and -460 polymorphisms of vascular endothelial growth factor in psoriasis and short-term responsiveness to efalizumab therapy. (18583913)
2008
25
Guttate psoriasis induced by infliximab in a child with Crohn's disease. (18383177)
2008
26
Biological markers in the etiology of psoriasis: Targeted treatment options. (19707344)
2007
27
Alefacept: its safety profile, off-label uses, and potential as part of combination therapies for psoriasis. (17671880)
2007
28
Possible association of psoriasis and reduced bone mineral density due to increased TNF-alpha and IL-6 concentrations. (16844318)
2006
29
Efalizumab: a biological agent for the treatment of psoriasis. (18473968)
2006
30
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. (17074928)
2006
31
Psychological factors in prurigo nodularis in comparison with psoriasis vulgaris: results of a case-control study. (16403095)
2006
32
Plasma and scales levels of interleukin 18 in comparison with other possible clinical and laboratory biomarkers of psoriasis activity. (16766395)
2006
33
Effect of psoriasis treatment on plasma concentrations of metalloproteinase-1 and tissue inhibitor of metalloproteinases-1. (15987285)
2005
34
Efalizumab: continuous therapy for chronic psoriasis. (15833076)
2005
35
Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). (16380428)
2005
36
Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis. (14699978)
2004
37
Alteration of the expression of Bcl-2, Bcl-x, Bax, Fas, and Fas ligand in the involved skin of psoriasis vulgaris following topical anthralin therapy. (12566829)
2003
38
A simple technique for high-throughput screening of drugs that modulate normal and psoriasis-like differentiation in cultured human keratinocytes. (12218287)
2002
39
Non-M protein(s) on the cell wall and membrane of group A streptococci induce(s) IFN-gamma production by dermal CD4+ T cells in psoriasis. (11380148)
2001
40
Successful treatment of severe psoriasis with basiliximab, an interleukin-2 receptor monoclonal antibody. (10844492)
2000
41
Possible contribution of stem cell factor in psoriasis vulgaris. (11084298)
2000
42
Clinical analysis of staphylococcal superantigen hyper-reactive patients with psoriasis vulgaris. (9683864)
1998
43
Picture of the month. Acute guttate psoriasis. (8362797)
1993
44
Immunoblotting of streptococcal antigens in guttate psoriasis. (8457448)
1993
45
Generalized pustular psoriasis in relation to withdrawal of cyclosporin A. (2354124)
1990
46
Generalized pustular psoriasis in a child. (4007219)
1985
47
Letter: Subcorneal pustular dermatosis vs pustular psoriasis. (4420076)
1974
48
Generalized pustular psoriasis. (5058170)
1972
49
Glyceraldehydephosphate dehydrogenase and glucose-6-phosphate dehydrogenase activities in psoriasis and neurodermatitis and the effect of dithranol. (5412727)
1970
50
Generalized pustular psoriasis. (5790267)
1969

Genetic Variations for Psoriasis

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Expression for genes affiliated with Psoriasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psoriasis

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Pathways for genes affiliated with Psoriasis

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51QIAGEN, 29KEGG
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Compounds for genes affiliated with Psoriasis

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Psoriasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pge24411.1ALOX5AP, IL17A, AREG, CCL2
2allopurinol44 49 1112.9PSORS1C2, PSORS1C3, PSORS1C1
3actinomycin d4410.8CCL2, AREG, IL17A, ALOX5AP

GO Terms for genes affiliated with Psoriasis

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16Gene Ontology
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Biological processes related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:04567210.8IL17A, IL20

Products for genes affiliated with Psoriasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Psoriasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet