MCID: PSR002
MIFTS: 63

Psoriasis malady

Genetic diseases, Rare diseases, Skin diseases categories
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Summaries for Psoriasis

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MedlinePlus:33 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people who have psoriasis also get a form of arthritis called psoriatic arthritis. a problem with your immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in your skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because your cells rise too fast. psoriasis can be hard to diagnose because it can look like other skin diseases. your doctor might need to look at a small skin sample under a microscope. psoriasis can last a long time, even a lifetime. symptoms come and go. things that make them worse include infections stress dry skin certain medicines psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medicines, and light therapy. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Psoriasis is related to psoriatic arthritis and atopic dermatitis. An important gene associated with Psoriasis is PSORS1C1 (psoriasis susceptibility 1 candidate 1), and among its related pathways are Jak-STAT signaling pathway and TGF-Beta Pathway. The drugs anthralin and betamethasone and the compounds rantes and groalpha have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial, and related mouse phenotype immune system.

NIH Rare Diseases:42 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. the skin on the elbows, knees, scalp, back, face, palms and feet is most often affected, but other parts of the body can be affected as well. a problem with the immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in the skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because the cells rise too fast. although symptoms may come and go, for many, psoriasis is a lifelong condition. infections, stress, dry skin and certain medications may make symptoms worse. psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medications and light therapy. last updated: 2/12/2010

CDC:3 Psoriasis is a chronic, autoimmune skin disease that speeds up the growth cycle of skin cells.

Wikipedia:65 Psoriasis (/s??ra?.?s?s/; from Greek ????????, meaning \"itching condition\" or \"being itchy\", from... more...

Aliases & Classifications for Psoriasis

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Psoriasis, Aliases & Descriptions:

Name: Psoriasis 8 42 20 22 10 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:8893
ICD9CM27 696.5
ICD1025 L40, L40.9

Related Diseases for Psoriasis

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Diseases related to Psoriasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 395)
idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis32.0FBXL19, HLA-C
2atopic dermatitis31.5CCL2, S100A7, IL17A
3psoriasis susceptibility 131.2HLA-C
4skin disease31.1IL17A, HLA-C, FABP5, AREG, S100A7
5rheumatoid arthritis30.8IL17A, CCL2, ALOX5AP, IL21, AREG
6uveitis30.7CCL2, HLA-C, IL17A
7inflammatory bowel disease30.6IL17A, AREG, CCL2, IL21
8glomerulonephritis30.6ALOX5AP, AREG, CCL2
9demyelinating disease30.4CCL2, IL17A
10pneumonia30.3IL17A, CCL2, ALOX5AP
11multiple sclerosis30.2IL17A, CCL2, HLA-C
12asthma30.1ALOX5AP, AREG, IL17A, CCL2
13generalized pustular psoriasis11.0
14arthritis11.0
15guttate psoriasis10.8
16dermatitis10.8
17endotheliitis10.5
18alopecia10.5
19bullous pemphigoid10.5
20vitiligo10.5
21trachoma10.5S100A7
22hepatitis10.4
23stevens-johnson syndrome10.4PSORS1C1, HLA-C
24crohn's disease10.4
25pemphigus10.4
26alopecia areata10.4
27obesity10.3
28pityriasis rubra pilaris10.3
29blindness10.3
30pustulosis palmaris et plantaris10.3
31hypersensitivity reaction type ii disease10.3IL17A, HLA-C, CCL2
32acne10.3
33chronic obstructive pulmonary disease10.3CCL2, IL17A, AREG
34lichen planus10.3
35porokeratosis10.3
36spondylitis10.3
37thyroiditis10.3
38epidermal nevus10.3
39central nervous system disease10.3IL17A, CCL2
40ankylosing spondylitis10.3
41contact dermatitis10.3
42allergic asthma10.3ALOX5AP, CCL2, IL17A
43acute generalized exanthematous pustulosis10.3
44mycosis fungoides10.2
45pemphigus foliaceus10.2
46impetigo herpetiformis10.2
47enthesopathy10.2
48lupus erythematosus10.2
49scabies10.2
50diabetes mellitus10.2

Graphical network of the top 20 diseases related to Psoriasis:



Diseases related to psoriasis

Symptoms for Psoriasis

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Genetic Tests for Psoriasis

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Genetic tests related to Psoriasis:

id Genetic test Affiliating Genes
1 Psoriasis20 22

Anatomical Context for Psoriasis

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MalaCards organs/tissues related to Psoriasis:

32
Skin, T cells, Endothelial, Neutrophil, Monocytes, Liver, Thyroid, Testes, Lung, Bone, Tongue, Heart, Tonsil, Bone marrow, Pituitary, Eye, Kidney, Colon, Thymus, Ovary, Myeloid, B cells

Animal Models for Psoriasis or affiliated genes

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MGI Mouse Phenotypes related to Psoriasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.2AREG, ALOX5AP, IL20RA, IL17A, IL21, CCL2

Publications for Psoriasis

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Articles related to Psoriasis:

(show top 50)    (show all 2606)
idTitleAuthorsYear
1
A possible role of polycystic ovary syndrome for pregnancy complications in women with psoriasis. (25381981)
2014
2
Nail Psoriasis, the unknown burden of disease. (24422908)
2014
3
Management of psoriasis in patients treated with anti-TNF-I+ therapy for inflammatory bowel disease. (23972498)
2013
4
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting. (23908546)
2013
5
Influence of neutralizing antibodies to adalimumab and infliximab on the treatment of psoriasis. (24329764)
2013
6
Polymorphic pityriasis rosea precipitating psoriasis. (23437430)
2013
7
Cardiometabolic profile, clinical features, quality of life and treatment outcomes in patients with moderate-to-severe psoriasis and psoriatic arthritis. (24283931)
2013
8
NF-I_B: an essential transcription factor in psoriasis. (23219896)
2013
9
Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis? (23497068)
2013
10
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. (24211183)
2013
11
Psoriasis and psoriatic arthritis video project: an update from the 2010 GRAPPA annual meeting. (22298271)
2012
12
Power of crowdsourcing: novel methods of data collection in psoriasis and psoriatic arthritis. (22818792)
2012
13
A case of psoriasis with secondary amyloidosis, associated symbrachydactyly of the hand and a transverse deficiency of the foot. (22953651)
2012
14
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (21839423)
2011
15
A novel splicing variant of CADM2 as a protective transcript of psoriasis. (21864505)
2011
16
IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients. (21613309)
2011
17
Erythema multiforme during anti-tumor necrosis factor treatment for plaque psoriasis. (19913942)
2010
18
Expression, localisation and functional activation of NFAT-2 in normal human skin, psoriasis, and cultured keratocytes. (19684889)
2009
19
Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes. (19587699)
2009
20
Management of moderate to severe plaque psoriasis (part I): clinical update on antitumor necrosis factor agents. (19213230)
2009
21
Goeckerman's therapy for psoriasis with special reference to serum pentraxin 3 level. (18986345)
2008
22
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. (18700910)
2008
23
Investigation of +405 and -460 polymorphisms of vascular endothelial growth factor in psoriasis and short-term responsiveness to efalizumab therapy. (18583913)
2008
24
Combined effects of HLA-Cw6, body mass index and waist-hip ratio on psoriasis vulgaris in Chinese Han population. (18585007)
2008
25
Immune-mediated inflammatory diseases and psoriasis]. (18466796)
2008
26
Variants in the 5q31 cytokine gene cluster are associated with psoriasis. (18075513)
2008
27
Polymorphisms in the interferon regulatory factor-1 promoter are not associated with psoriasis and do not influence IFN-alpha-induced Th1 polarization. (17970693)
2007
28
Unraveling the paradoxes of HIV-associated psoriasis: a review of T-cell subsets and cytokine profiles. (17498423)
2007
29
Clinical relevance of nerve growth factor serum levels in patients with atopic dermatitis and psoriasis. (17579279)
2007
30
Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population. (17714919)
2007
31
Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes. (16965413)
2006
32
Effect of psoriasis activity on metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in plasma and lesional scales. (16585983)
2006
33
A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis. (16882185)
2006
34
Effect of psoriasis treatment on plasma concentrations of metalloproteinase-1 and tissue inhibitor of metalloproteinases-1. (15987285)
2005
35
Punctate palmoplantar keratoderma (Buschke-Fischer-Brauer disease) with psoriasis: a rare association showing excellent response to acitretin. (16167422)
2005
36
Biology of tumor necrosis factor-alpha- implications for psoriasis. (15086336)
2004
37
Efalizumab in the treatment of psoriasis. (15379774)
2004
38
Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris. (15140215)
2004
39
Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis. (14699978)
2004
40
Elevated plasma levels of vascular endothelial growth factor and plasminogen activator inhibitor-1 decrease during improvement of psoriasis. (12540021)
2002
41
Clinical and immunologic assessment of patients with psoriasis in a randomized, double-blind, placebo-controlled trial using recombinant human interleukin 10. (12374540)
2002
42
Polymorphisms in inflammation genes (angiotensinogen, TAP1 and TNF-beta) in psoriasis. (11194890)
2000
43
Changes in keratin 6 and keratin 10 (co-)expression in lesional and symptomless skin of spreading psoriasis. (10971053)
2000
44
Polymorphisms of HLA-DM genes in Japanese patients with psoriasis vulgaris. (10417524)
1999
45
Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene. (10545595)
1999
46
The chemotactic activity of T-lymphocytes in response to interleukin 8 is significantly decreased in patients with psoriasis and atopic dermatitis. (9028795)
1996
47
Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. (8034808)
1994
48
Activity of beta-glucuronidase and acid phosphatase in fractions of granulocytes isolated from PMNL in peripheral blood of patients with psoriasis]. (8090655)
1993
49
Mast cell degranulation in the evolution of acute eruptive guttate psoriasis vulgaris. (6512269)
1984
50
Exfoliative dermatitis after undecylenic acid therapy for psoriasis. (14774148)
1950

Variations for Psoriasis

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Expression for genes affiliated with Psoriasis

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Expression patterns in normal tissues for genes affiliated with Psoriasis

Search GEO for disease gene expression data for Psoriasis.

Pathways for genes affiliated with Psoriasis

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Compounds for genes affiliated with Psoriasis

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Sources:
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Compounds related to Psoriasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes4410.0CCL2, IL21, IL17A
2groalpha449.9IL17A, CCL2
3actinomycin d449.8IL17A, CCL2, ALOX5AP, AREG
4prostaglandin449.8IL17A, ALOX5AP, AREG
5pge2449.7AREG, CCL2, IL17A, ALOX5AP

GO Terms for genes affiliated with Psoriasis

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Cellular components related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.7IL20, IL17A, IL21, MICA, CCL2
2extracellular regionGO:0055769.1S100A7, HLA-C, LYNX1, PSORS1C2, CCL2, IL20

Biological processes related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:04567210.2IL17A, IL20
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.2IL20, IL21
3response to heatGO:00940810.1CCL2, MICA
4cellular response to interleukin-1GO:07134710.1IL17A, CCL2
5cytokine-mediated signaling pathwayGO:0192219.7HLA-C, CCL2, IL20RA

Molecular functions related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.0IL20, IL17A, IL21

Products for genes affiliated with Psoriasis

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Sources for Psoriasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet