MCID: PSR002
MIFTS: 63

Psoriasis malady

Genetic diseases, Rare diseases, Skin diseases categories
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Summaries for Psoriasis

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Sources:
43NIH Rare Diseases, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people who have psoriasis also get a form of arthritis called psoriatic arthritis. a problem with your immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in your skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because your cells rise too fast. psoriasis can be hard to diagnose because it can look like other skin diseases. your doctor might need to look at a small skin sample under a microscope. psoriasis can last a long time, even a lifetime. symptoms come and go. things that make them worse include infections stress dry skin certain medicines psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medicines, and light therapy. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Psoriasis is related to psoriatic arthritis and atopic dermatitis. An important gene associated with Psoriasis is PSORS1C1 (psoriasis susceptibility 1 candidate 1), and among its related pathways are Jak-STAT signaling pathway and TGF-Beta Pathway. The drugs anthralin and betamethasone and the compounds rantes and groalpha have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial, and related mouse phenotype immune system.

NIH Rare Diseases:43 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. the skin on the elbows, knees, scalp, back, face, palms and feet is most often affected, but other parts of the body can be affected as well. a problem with the immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in the skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because the cells rise too fast. although symptoms may come and go, for many, psoriasis is a lifelong condition. infections, stress, dry skin and certain medications may make symptoms worse. psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medications and light therapy. last updated: 2/12/2010

CDC:4 Psoriasis is a chronic, autoimmune skin disease that speeds up the growth cycle of skin cells.

Wikipedia:65 Psoriasis (/s??ra?.?s?s/; from Greek ????????, meaning \"itching condition\" or \"being itchy\", from... more...

Aliases & Classifications for Psoriasis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

psoriasis 8 43 20 22 10 45 34 62


External Ids:

Disease Ontology8 DOID:8893
ICD9CM27 696.5
ICD1025 L40, L40.9

Related Diseases for Psoriasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Psoriasis:



Diseases related to psoriasis

Symptoms for Psoriasis

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Genetic Tests for Psoriasis

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20GeneTests, 22GTR
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Genetic tests related to Psoriasis:

id Genetic test Affiliating Genes
1 Psoriasis20 22

Anatomical Context for Psoriasis

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33MalaCards
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MalaCards organs/tissues related to Psoriasis:

33
Skin, T cells, Endothelial, Monocytes, Liver, Thyroid, Testes, Bone, Lung, Heart, Tongue, Bone marrow, Kidney, Eye, Tonsil, Colon, Pituitary, Myeloid, B cells, Thymus

Animal Models for Psoriasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Psoriasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.2AREG, ALOX5AP, IL20RA, IL17A, IL21, CCL2

Publications for Psoriasis

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52PubMed
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Articles related to Psoriasis:

(show top 50)    (show all 2492)
idTitleAuthorsYear
1
Nail Psoriasis, the unknown burden of disease. (24422908)
2014
2
Management of psoriasis in patients treated with anti-TNF-I+ therapy for inflammatory bowel disease. (23972498)
2013
3
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting. (23908546)
2013
4
Influence of neutralizing antibodies to adalimumab and infliximab on the treatment of psoriasis. (24329764)
2013
5
Polymorphic pityriasis rosea precipitating psoriasis. (23437430)
2013
6
Cardiometabolic profile, clinical features, quality of life and treatment outcomes in patients with moderate-to-severe psoriasis and psoriatic arthritis. (24283931)
2013
7
NF-I_B: an essential transcription factor in psoriasis. (23219896)
2013
8
Interferon-I^ release assay for tuberculosis in patients with psoriasis treated with tumour necrosis factor antagonists: in vivo and in vitro analysis. (23909256)
2013
9
Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis? (23497068)
2013
10
Psoriasis and psoriatic arthritis video project: an update from the 2010 GRAPPA annual meeting. (22298271)
2012
11
Power of crowdsourcing: novel methods of data collection in psoriasis and psoriatic arthritis. (22818792)
2012
12
A case of psoriasis with secondary amyloidosis, associated symbrachydactyly of the hand and a transverse deficiency of the foot. (22953651)
2012
13
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (21839423)
2011
14
A novel splicing variant of CADM2 as a protective transcript of psoriasis. (21864505)
2011
15
IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients. (21613309)
2011
16
Erythema multiforme during anti-tumor necrosis factor treatment for plaque psoriasis. (19913942)
2010
17
Expression, localisation and functional activation of NFAT-2 in normal human skin, psoriasis, and cultured keratocytes. (19684889)
2009
18
Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes. (19587699)
2009
19
Management of moderate to severe plaque psoriasis (part I): clinical update on antitumor necrosis factor agents. (19213230)
2009
20
Goeckerman's therapy for psoriasis with special reference to serum pentraxin 3 level. (18986345)
2008
21
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. (18700910)
2008
22
Investigation of +405 and -460 polymorphisms of vascular endothelial growth factor in psoriasis and short-term responsiveness to efalizumab therapy. (18583913)
2008
23
Combined effects of HLA-Cw6, body mass index and waist-hip ratio on psoriasis vulgaris in Chinese Han population. (18585007)
2008
24
Immune-mediated inflammatory diseases and psoriasis]. (18466796)
2008
25
Variants in the 5q31 cytokine gene cluster are associated with psoriasis. (18075513)
2008
26
Polymorphisms in the interferon regulatory factor-1 promoter are not associated with psoriasis and do not influence IFN-alpha-induced Th1 polarization. (17970693)
2007
27
Unraveling the paradoxes of HIV-associated psoriasis: a review of T-cell subsets and cytokine profiles. (17498423)
2007
28
Clinical relevance of nerve growth factor serum levels in patients with atopic dermatitis and psoriasis. (17579279)
2007
29
Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population. (17714919)
2007
30
Immunopathogenesis of psoriasis and psoriatic arthritis and pharmacological perspectives. (17828356)
2007
31
Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes. (16965413)
2006
32
Effect of psoriasis activity on metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in plasma and lesional scales. (16585983)
2006
33
A placebo-controlled randomized study on the clinical effectiveness, immunohistochemical changes and protoporphyrin IX accumulation in fractionated 5-aminolaevulinic acid-photodynamic therapy in patients with psoriasis. (16882185)
2006
34
Effect of psoriasis treatment on plasma concentrations of metalloproteinase-1 and tissue inhibitor of metalloproteinases-1. (15987285)
2005
35
Punctate palmoplantar keratoderma (Buschke-Fischer-Brauer disease) with psoriasis: a rare association showing excellent response to acitretin. (16167422)
2005
36
Biology of tumor necrosis factor-alpha- implications for psoriasis. (15086336)
2004
37
Efalizumab in the treatment of psoriasis. (15379774)
2004
38
Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris. (15140215)
2004
39
Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis. (14699978)
2004
40
Elevated plasma levels of vascular endothelial growth factor and plasminogen activator inhibitor-1 decrease during improvement of psoriasis. (12540021)
2002
41
Clinical and immunologic assessment of patients with psoriasis in a randomized, double-blind, placebo-controlled trial using recombinant human interleukin 10. (12374540)
2002
42
Polymorphisms in inflammation genes (angiotensinogen, TAP1 and TNF-beta) in psoriasis. (11194890)
2000
43
Changes in keratin 6 and keratin 10 (co-)expression in lesional and symptomless skin of spreading psoriasis. (10971053)
2000
44
Polymorphisms of HLA-DM genes in Japanese patients with psoriasis vulgaris. (10417524)
1999
45
Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene. (10545595)
1999
46
The chemotactic activity of T-lymphocytes in response to interleukin 8 is significantly decreased in patients with psoriasis and atopic dermatitis. (9028795)
1996
47
Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. (8034808)
1994
48
Activity of beta-glucuronidase and acid phosphatase in fractions of granulocytes isolated from PMNL in peripheral blood of patients with psoriasis]. (8090655)
1993
49
Mast cell degranulation in the evolution of acute eruptive guttate psoriasis vulgaris. (6512269)
1984
50
Exfoliative dermatitis after undecylenic acid therapy for psoriasis. (14774148)
1950

Variations for Psoriasis

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Expression for genes affiliated with Psoriasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psoriasis

Search GEO for disease gene expression data for Psoriasis.

Pathways for genes affiliated with Psoriasis

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN
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Compounds for genes affiliated with Psoriasis

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45Novoseek
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Compounds related to Psoriasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rantes4510.0CCL2, IL21, IL17A
2groalpha459.9IL17A, CCL2
3actinomycin d459.8IL17A, CCL2, ALOX5AP, AREG
4prostaglandin459.8IL17A, ALOX5AP, AREG
5pge2459.7AREG, CCL2, IL17A, ALOX5AP

GO Terms for genes affiliated with Psoriasis

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16Gene Ontology
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Cellular components related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.7IL20, IL17A, IL21, MICA, CCL2
2extracellular regionGO:0055769.1S100A7, HLA-C, LYNX1, PSORS1C2, CCL2, IL20

Biological processes related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:04567210.2IL17A, IL20
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.2IL20, IL21
3response to heatGO:00940810.1CCL2, MICA
4cellular response to interleukin-1GO:07134710.1IL17A, CCL2
5cytokine-mediated signaling pathwayGO:0192219.7HLA-C, CCL2, IL20RA

Molecular functions related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.0IL20, IL17A, IL21

Products for genes affiliated with Psoriasis

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Sources for Psoriasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet