MCID: PSR002
MIFTS: 60

Psoriasis malady

Skin diseases category

Summaries for Psoriasis

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people who have psoriasis also get a form of arthritis called psoriatic arthritis. a problem with your immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in your skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because your cells rise too fast. psoriasis can be hard to diagnose because it can look like other skin diseases. your doctor might need to look at a small skin sample under a microscope. psoriasis can last a long time, even a lifetime. symptoms come and go. things that make them worse include infections stress dry skin certain medicines psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medicines, and light therapy. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Psoriasis is related to arthritis and psoriatic arthritis. An important gene associated with Psoriasis is PSORS1C1 (psoriasis susceptibility 1 candidate 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The drugs cyclosporine and hydroxyurea and the compounds pge2 and allopurinol have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

NIH Rare Diseases:42 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. the skin on the elbows, knees, scalp, back, face, palms and feet is most often affected, but other parts of the body can be affected as well. a problem with the immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in the skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because the cells rise too fast. although symptoms may come and go, for many, psoriasis is a lifelong condition. infections, stress, dry skin and certain medications may make symptoms worse. psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medications and light therapy. last updated: 2/12/2010

CDC:3 Psoriasis is a chronic, autoimmune skin disease that speeds up the growth cycle of skin cells.

Wikipedia:63 Psoriasis (pronounced /sɵˈraɪ.əsɨs/; from Greek ψωρίασις, meaning \"itching condition\" or... more...

Aliases & Classifications for Psoriasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

psoriasis 8 42 20 22 10 44 33 60


External Ids:

Disease Ontology8 DOID:8893
ICD9CM27 696.5
ICD1025 L40, L40.9

Related Diseases for Psoriasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Psoriasis:



Diseases related to psoriasis

Clinical Features for Psoriasis

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Genetic Tests for Psoriasis

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20GeneTests, 22GTR
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Genetic tests related to Psoriasis:

id Genetic test Affiliating Genes
1 Psoriasis20 22

Anatomical Context for Psoriasis

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32MalaCards
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MalaCards organs/tissues related to Psoriasis:

32
Skin, T cells, Endothelial, Monocytes, Liver, Thyroid, Testes, Bone, Lung, Heart, Tongue, Bone marrow, Kidney, Eye, Tonsil, Colon, Pituitary, Myeloid, B cells, Thymus

Animal Models for Psoriasis or affiliated genes

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Publications for Psoriasis

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Sources:
50PubMed
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Articles related to Psoriasis:

(show top 50)    (show all 2518)
idTitleAuthorsYear
1
Do Malassezia species play a role in exacerbation of scalp psoriasis? (24411177)
2014
2
Psoriasis treatment: faster and long-standing results after bathing in geothermal seawater. A randomized trial of three UVB phototherapy regimens. (24255991)
2014
3
Imatinib-induced psoriasis. (24385791)
2013
4
Effect of treatment on prolactin levels in patients with psoriasis vulgaris. (24370384)
2013
5
Comorbidities in psoriasis. (23974690)
2013
6
Impact of brodalumab treatment on psoriasis symptoms and health-related quality of life: Use of a novel patient-reported outcome measure, the Psoriasis Symptom Inventory. (24079852)
2013
7
One year safety and efficacy of ustekinumab and results of dose adjustment after switching from inadequate methotrexate treatment: the TRANSIT randomized trial in moderate-to-severe plaque psoriasis. (24116868)
2013
8
Subclinical inflammation and cardiovascular risk in psoriasis. (24372585)
2013
9
Non-segmental vitiligo and psoriasis comorbidity - a case-control study in Italian patients. (23441884)
2013
10
Treatment of severe psoriasis with biological therapies in patients with viral hepatitis B and C. (23445306)
2013
11
Neurofibromatosis associated with plaque-type psoriasis: coincidental occurrence or causal association? (23094315)
2012
12
Psoriasis: a skin disease associated with increased cardiovascular risk. (22465257)
2012
13
HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction. (21412248)
2011
14
Coexisting bullous pemphigoid and psoriasis successfully treated with etanercept. (20403800)
2010
15
Disseminated superficial porokeratosis secondary to immunosuppression induced by etanercept for extensive psoriasis. (20956674)
2010
16
Cure of Psoriasis and Arthritis when Addison's Disease Was Detected. (21103194)
2010
17
Development of bullous pemphigoid during treatment of psoriasis with adalimumab. (19438555)
2009
18
AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. (19876791)
2009
19
IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. (19175939)
2009
20
Enhanced proliferation and activation of peripheral blood mononuclear cells in patients with psoriasis vulgaris mediated by streptococcal antigen with bacterial DNA. (19609313)
2009
21
Arthritis due to Wilson disease, penicillamine, psoriasis or hepatocellular carcinoma? Blurred focus, sharp boundaries. (20087277)
2009
22
Depression and quality of life in psoriasis. (19641281)
2009
23
High prevalence of concomitant anogenital lichen sclerosus and extragenital psoriasis in adult women. (18448747)
2008
24
Expression of E-cadherin, beta-catenin and cyclin D1 in epidermal skin lesions of patients with active psoriasis vulgaris]. (18495586)
2008
25
Anti-tumour necrosis factor-alpha therapy increases body weight in patients with chronic plaque psoriasis: a retrospective cohort study. (18005022)
2008
26
Adalimumab improves health-related quality of life in patients with moderate to severe plaque psoriasis compared with the United States general population norms: results from a randomized, controlled Phase III study. (18831744)
2008
27
Bcl-2 expression in dermal lymphocytes in lichen planus and psoriasis vulgaris. (18410632)
2008
28
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. (17603494)
2007
29
Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis. (17340018)
2007
30
TNF polymorphisms in psoriasis: association of psoriatic arthritis with the promoter polymorphism TNF*-857 independent of the PSORS1 risk allele. (17530646)
2007
31
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. (16619290)
2006
32
Assessment of epidermal subpopulations and proliferation in healthy skin, symptomless and lesional skin of spreading psoriasis. (16965416)
2006
33
Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene- therapeutic effects. (15608502)
2005
34
Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis. (15496954)
2004
35
Major histocompatibility complex class I chain-related gene A in Thai psoriasis patients: MICA association as a part of human leukocyte antigen-B-Cw haplotypes. (15140030)
2004
36
Simultaneous measurement of multiple Th1 and Th2 serum cytokines in psoriasis and correlation with disease severity. (14760939)
2003
37
SLURP-2, a novel member of the human Ly-6 superfamily that is up- regulated in psoriasis vulgaris. (12573258)
2003
38
A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (12653732)
2003
39
Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population. (12930300)
2003
40
Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. (11310827)
2001
41
Crusted scabies looking like psoriasis. (10968439)
2000
42
Levels of proelafin peptides in the sera of the patients with generalized pustular psoriasis and pustulosis palmoplantaris. (10877128)
2000
43
Aberrant caveolin-1 expression in psoriasis: a signalling hypothesis. (11327308)
2000
44
Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris. (10777095)
2000
45
Juvenile generalized pustular psoriasis. (8919525)
1996
46
Pathogenesis of psoriasis. (8785878)
1995
47
Association between HLA antigens and families with psoriasis vulgaris. (8504697)
1993
48
Ectropion: an adverse effect of etretinate therapy for psoriasis. (2244393)
1990
49
Electron microscopic features in generalized pustular psoriasis. (2439612)
1987
50
Generalized pustular psoriasis and bacteremia. (6368631)
1983

Genetic Variations for Psoriasis

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Expression for genes affiliated with Psoriasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psoriasis

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Pathways for genes affiliated with Psoriasis

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51QIAGEN, 29KEGG
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Compounds for genes affiliated with Psoriasis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Psoriasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pge24411.1ALOX5AP, IL17A, AREG, CCL2
2allopurinol44 49 1112.9PSORS1C2, PSORS1C3, PSORS1C1
3actinomycin d4410.8CCL2, AREG, IL17A, ALOX5AP

GO Terms for genes affiliated with Psoriasis

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16Gene Ontology
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Biological processes related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:04567210.8IL17A, IL20

Products for genes affiliated with Psoriasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Psoriasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet