Psoriasis malady

MedlinePlus: Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get them on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. a problem with your immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in your skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because your cells rise too fast. psoriasis can last a long time, even a lifetime. symptoms come and go. things that make them worse include infections stress dry skin certain medicines psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medications and light therapy. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Psoriasis is related to carcinoma and leukemia. An important gene associated with Psoriasis is FABP5 (fatty acid binding protein 5 (psoriasis-associated)), and among its related pathways are p38 Signaling and Tec Kinases Signaling. The drugs coal tar and betamethasone dipropionate and the compounds thymidine and fmlp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and heart, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Genetics Home Reference: Psoriatic arthritis is a condition involving joint inflammation (arthritis) that usually occurs in combination with a skin disorder called psoriasis. Psoriasis is a chronic inflammatory condition characterized by patches of red, irritated skin that are often covered by flaky white scales. People with psoriasis may also have changes in their fingernails and toenails, such as nails that become pitted or ridged, crumble, or separate from the nail beds.¹⁷

Wikipedia: Psoriasis (pron.: /sɵˈraɪ.əsɨs/) is an immune-mediated disease that affects the skin. It occurs...⁴⁴ more...

Aliases & Descriptions:

psoriasis 6 16 8 32 23 43

Diseases related to psoriasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 954)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	85.4	ZNF148, PI3, LRIG1, LRP1, RFC1, PDE4A
2	leukemia	69.4	LRP1, RFC1, PDE4A, RETN, CNR1, KIR2DS3
3	dermatitis	64.3	ZNF750, PI3, PDE4A, CNR1, KIR3DL2, KITLG
4	melanoma	61.6	PI3, LRP1, PDE4A, KIR3DL2, KIR2DL1, KIR2DL3
5	thyroiditis	57.6	LRP1, RFC1, PDE4A, RETN, KITLG, VTN
6	tuberculosis	55.7	KIR2DL1, SFTPD, SERPINC1, SERPINF2, SERPINA1, SERPINB1
7	neuronitis	54.4	ZNF148, LRP1, PDE4A, RETN, CNR1, KITLG
8	atopic dermatitis	51.7	PDE4A, KITLG, SELE, SELP, VIP, NAT2
9	skin disease	50.4	PI3, PDE4A, VTN, SFTPD, SELE, SERPINB13
10	squamous cell carcinoma	50.2	PI3, VTN, PCNA, SERPINB3, SERPINB13, SERPINB2
11	atherosclerosis	48.4	PI3, LRP1, PDE4A, RETN, CNR1, VTN
12	inflammatory bowel disease	47.0	PDE4A, RETN, SELE, SELP, SELPLG, SERPINA1
13	diabetes mellitus	46.1	PI3, PDE4A, RETN, CNR1, KIR2DS5, KIR3DS1
14	ulcerative colitis	44.9	PI3, PDE4A, SELE, SELP, SERPINA1, VIP
15	obesity	44.1	LRP1, RETN, CNR1, KIR2DL1, KIR2DL3, KIR2DS4
16	hypoxia	42.8	LRP1, PDE4A, KITLG, VTN, PCNA, SELE
17	contact dermatitis	41.4	PI3, PDE4A, CNR1, SELE, SELP, VNN3
18	hypertension	41.2	LRP1, RFC1, PDE4A, RETN, CNR1, PCNA
19	crohn's disease	41.1	CHI3L1, T, MPO, CDH3, CD80, ITGA1
20	gonococcal synovitis	40.3	PI3, LRP1, PDE4A, RETN, CNR1, KITLG
21	immunodeficiency	40.3	KIR3DL1, VIP, CIITA, S100A12, CFLAR, CD28
22	celiac disease	40.1	KIR3DL1, KIR2DL5A, SELE, VDR, BGLAP, LEP
23	leprosy	40.0	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1, KIR2DL1
24	lung carcinoma	39.5	SFTPD, PCNA, SERPINB3, SERPINB2, SERPINA1, SERPINA3
25	blindness	39.1	PDE4A, CNR1, SELE, SELP, SERPINC1, VIP
26	mycosis fungoides	38.9	PCNA, SELE, SELP, SELPLG, VCAM1, BCL2
27	arthritis	38.1	SERPINA1, VIP, MMP3, IL17A, IL1A, IL1B
28	psoriatic arthritis	37.4	MIR146A, IL10, IL1B, IL1RAPL2, IL1RN, IL6
29	prostatitis	37.0	ZNF750, LRIG1, LRP1, RFC1, PDE4A, RETN
30	vasculitis	36.8	LRP1, SELE, SELP, SELPLG, SERPINC1, SERPINA1
31	spondylitis	36.8	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1, KIR2DL1
32	lichen planus	36.6	PCNA, VEGFA, VCAM1, BCL2, MX1, BAX
33	adult t-cell leukemia	35.6	KIR2DL1, KIR2DL3, BCL2, BCL2L1, CIITA, MX1
34	rheumatoid arthritis	35.2	CIITA, MTHFR, CD226, CD40, MICB, MICA
35	purpura	34.7	SELE, SELP, SERPINC1, SERPINF2, VEGFA, VCAM1
36	duodenitis	34.3	KITLG, PCNA, VIP, VDR, RARB, CMA1
37	basal cell carcinoma	34.0	PI3, VDR, RARA, BCL2, BAK1, BAX
38	adenocarcinoma	33.8	ZNF148, LRP1, CNR1, KITLG, VTN, SFTPD
39	vitiligo	33.7	KITLG, VDR, BIRC5, CIITA, BAX, MPO
40	pemphigus	33.6	CIITA, CHRNA7, BAX, JUN, CD79A, CDK2
41	graft versus host disease	33.6	KIR3DL1, CD28, ITGAL, GZMB, FGF7, IL10
42	thrombocytopenia	33.5	KITLG, SELE, SELP, SERPINC1, RAF1, MTHFR
43	t-cell leukemia	33.5	RAF1, BIRC5, BCL2, BCL2L1, JUN, JUNB
44	hepatitis c	33.4	SERPINA1, CIITA, MX1, LDLR, JUN, JAK1
45	arthropathy	33.4	RETN, KITLG, VTN, BGLAP, CIITA, CHI3L1
46	pancreatitis	33.3	ZNF148, PI3, LRP1, PDE4A, RETN, CNR1
47	synovitis	33.3	LRIG3, PCNA, SELE, SERPINA1, VEGFA, VCAM1
48	bullous pemphigoid	33.0	SERPINF2, CIITA, CD79A, IVL, ITGAL, FLG
49	ichthyosis	32.7	SERPINB2, CLDN1, LELP1, IVL, FLG, LOR
50	cervicitis	32.7	LRIG1, LRIG2, RFC1, PDE4A, CNR1, KIR3DL2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acitretin, alefacept, aloe vera, anthralin, anthralin pwdr [va product], betamethasone, betamethasone acetate, betamethasone benzoate, betamethasone dipropionate, betamethasone sodium phosphate, betamethasone valerate, betamethasone valerate pwdr [va product], calcipotriene, calcitriol, cholecalciferol, coal tar, coal tar distillate, coal tar distillate [va product], coal tar extract, coal tar,colloidal, coal tar,crude, coal tar,refined, cod liver oil [va product], etretinate, fish liver oil, fluocinolone, fluocinolone acetonide, hydroxyurea, methotrexate, methotrexate sodium, methoxsalen, mycophenolate mofetil, mycophenolate mofetil hydrochloride, mycophenolic acid, salicylic acid, salicylic acid pwdr [va product], sulfur, sulfur pwdr [va product], sulfur,colloidal, sulfur,precipitated, tazarotene, thioguanine, trioxsalen

Genetic tests related to psoriasis:

id	Genetic test	Affiliating Genes
1	Psoriasis clinical/research

MalaCards organs/tissues related to psoriasis:

²²

MGI Mouse Phenotypes related to psoriasis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	28.7	ZNF148, LRP1, RETN, CNR1, KITLG, VTN
2	mortality/aging	MP:0010768	27.1	ZNF148, LRP1, CNR1, KITLG, SFTPD, SELE
3	cellular phenotype	MP:0005384	24.4	ZNF148, LRIG1, CNR1, KITLG, PCNA, SELE
4	immune system phenotype	MP:0005387	21.6	ZNF148, LRP1, PDE4A, SELP, SELPLG, SERPINB2
5	cardiovascular system phenotype	MP:0005385	21.0	ZNF148, LRP1, PDE4A, KITLG, SELE, SELP
6	growth/size phenotype	MP:0005378	20.9	ZNF148, LRP1, CNR1, KITLG, SFTPD, SELE
7	integument phenotype	MP:0010771	20.7	ZNF148, LRIG1, CNR1, KITLG, SELP, SELPLG
8	hematopoietic system phenotype	MP:0005397	20.6	PCNA, SERPINB2, SERPINB1, VHL, CLDN7, CLIC1
9	normal phenotype	MP:0002873	19.7	ZNF148, LRIG1, LRP1, VTN, SELE, VIP
10	nervous system phenotype	MP:0003631	19.5	ZNF148, LRIG1, LRP1, PDE4A, CNR1, KITLG
11	behavior/neurological phenotype	MP:0005386	19.2	LRIG3, LRP1, CNR1, SELE, SELP, VIM
12	digestive/alimentary phenotype	MP:0005381	15.7	ZNF148, LRIG1, KITLG, VHL, VEGFA, VDR
13	skeleton phenotype	MP:0005390	15.5	LRP1, CNR1, KITLG, NAGLU, VHL, VEGFA
14	reproductive system phenotype	MP:0005389	15.4	ZNF148, VIP, NAT1, VHL, VEGFA, VDR
15	muscle phenotype	MP:0005369	14.8	LRP1, SERPINB2, VIM, VHL, VEGFA, RARA
16	tumorigenesis	MP:0002006	14.6	LRIG1, KITLG, VHL, RARA, BCL2, BCL2L1
17	renal/urinary system phenotype	MP:0005367	13.9	SELP, SELPLG, NAGLU, VHL, RARA, RARB
18	vision/eye phenotype	MP:0005391	13.7	KITLG, SELE, SELP, SERPINC1, VIM, NAGLU
19	endocrine/exocrine gland phenotype	MP:0005379	13.7	ZNF148, LRIG1, LDLR, FZD5, CDSN, CDKAL1
20	liver/biliary system phenotype	MP:0005370	13.6	RETN, SERPINC1, VHL, VEGFA, LIF, USP8
21	embryogenesis phenotype	MP:0005380	13.5	ZNF148, SERPINC1, VIM, NAT1, VHL, RARB
22	craniofacial phenotype	MP:0005382	13.3	LRIG1, LRIG3, KITLG, NAGLU, T, ITGA4
23	respiratory system phenotype	MP:0005388	13.2	SFTPD, SELP, SERPINB1, LIF, CHRNA7, CD14
24	limbs/digits/tail phenotype	MP:0005371	13.0	LRIG1, KITLG, VHL, VEGFA, VDR, RARA
25	no phenotypic analysis	MP:0003012	12.3	CNR1, PCNA, VEGFA, VCAM1, CLIC1, LDLR
26	other phenotype	MP:0005395	12.3	CNR1, RARA, RARB, KDR, LDLR, JAK2
27	adipose tissue phenotype	MP:0005375	11.5	LRP1, RETN, CNR1, LIF, BCL2, LEP
28	pigmentation phenotype	MP:0001186	11.3	KITLG, SERPINC1, NAGLU, BCL2, LEP, LDLR
29	hearing/vestibular/ear phenotype	MP:0005377	11.1	LRIG3, KITLG, NAGLU, VDR, RARA, RARB

Articles related to psoriasis:

(show top 50)    (show all 1095)

id	Title	Authors	Year	Affiliating Genes
1	Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis. (22521419)	Jordan C.T.... Bowcock A.M.	2012	NFKB1, CARD14
2	Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population. (21208785)	Zheng H.F.... Zhang X.J.	2011	IL12B, HLA-E, LCE3D
3	Psoriasis in patients with HIV infection: from the me dical board of the National Psoriasis Foundation. (19646777)	Menon K.... Strober B.E.	2010	TNF
4	Genetic variations in cytokines and cytokine receptors associated with psoriasis found by genome-wide association. (18830267)	Duffin K.C.... Krueger G.G.	2009	IL13, IL15, IL18R1
5	The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. (18948266)	Li W.... Kirchhofer D.	2009	PRSS22, PRSS27
6	Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction wi th PSORS1. (19525279)	HA1ffmeier U.... Reis A.	2009	HLA-C, PSORS6
7	Elevated plasma osteopontin level is associated with occurrence of psoriasis and is an unfavorable cardiovascular risk factor in patients with psoriasis. (19028408)	Chen Y.J.... Lee F.Y.	2009	SPP1
8	Assessment of insertion/deletion polymorphism of the angiotensin converting enzyme gene in psoriasis. (17920817)	Veletza S.... Papaioakim M.	2008	ACE
9	No Association between Polymorphisms in the Interleukin-15 Gene and Early-Onset Psoriasis in a UK Cohort Suggests Heterogeneity for this Susceptibility Locus Identified in Chinese Psoriasis Patients. (18580966)	Smith R.L.... Worthington J.	2008	IL15
10	Is CCR7 a potential target for biologic therapy in psoriasis?: Increased expression of CCR7 in psoriasis vulgaris. (19068542)	Fan X.... YuFeng L.	2008	CCR7
11	Effect of fumigation therapy with yinxieling on T-bet and GATA-3 protein expression in the peripheral blood monocyte of patients with psoriasis vulgaris (19317171)	Wei G.... Zhang C.M.	2008	GATA3, T
12	Unraveling the paradoxes of HIV-associated psoriasis: a review of T-cell subsets and cytokine profiles. (17498423)	Fife D.J.... Koo J.Y.	2007	IFNG
13	Associations of promoter region polymorphisms in the tumour necrosis factor-alpha gene and early-onset psoriasis vulgaris in a northern Polish population. (17553030)	Nedoszytko B.... Roszkiewicz J.	2007	TNF
14	Three retinoid X receptor gene polymorphisms in plaque psoriasis and psoriasis guttata. (17341859)	Vasku V.... Vasku A.	2007	RXRA, RXRB
15	Tissue angiotensin-converting enzyme in patients with various clinical forms of psoriasis. (17489742)	Huskic J.... Alendar F.	2007	ACE
16	Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris. (16709873)	Diluvio L.... Prinz J.C.	2006	TRB@
17	Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90). (16374458)	Wetzel A.... Saalbach A.	2006	ICAM1, THY1
18	Increased expression of the natural killer cell inhibitory receptor CD94/NKG2A and CD158b on circulating and lesional T cells in patients with chronic plaque psoriasis. (16882169)	Liao Y.H.... Tsai T.F.	2006	KLRD1, KIR2DL1, KLRC1
19	A - 308 promoter polymorphism of tumor necrosis factor alpha gene does not associate with the susceptibility to psoriasis vulgaris. No difference either between psoriasis type I and type II patients. (17053845)	Baran W.... Baran E.	2006	TNF
20	Association of HLA class I and class II alleles with psoriasis vulgaris in Turkish population. Influence of type I and II psoriasis. (16532100)	Atasoy M.... Aktas A.	2006	HLA-A, HLA-DRB1, HLA-C
21	Estimation of interleukin-6 level in psoriasis patients. (15859365)	Galadari I.... Sheriff M.O.	2005	IL6
22	Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis. (15908298)	Cardoso C.B.... Kraemer M.H.	2005	HLA-DQA1, HLA-DQB1, HLA-DRB1
23	The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis. (15654960)	Allen M.H.... Barker J.N.	2005	HLA-C, CCHCR1, CDSN
24	Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. (15186320)	Cook P.W.... Pittelkow M.R.	2004	AREG
25	TNFalpha therapy in psoriatic arthritis and psoriasis . (15194567)	Mease P.	2004	TNF
26	Psoriasis is not associated with IL-12p70/IL-12p40 production and IL12B promoter polymorphism. (15102082)	Litjens N.H.... Nibbering P.H.	2004	IL12B
27	Early effects of tumour necrosis factor alpha blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis. (15194570)	Goedkoop A.Y.... Tak P.P.	2004	TNF
28	Psoriasis genomics: analysis of proinflammatory (type 1) gene expression in large plaque (Western) and small plaque (Asian) psoriasis vulgaris. (15099362)	Lew W.... Krueger J.G.	2004	IL2RA, CCL2, IL8
29	Possible role of Malassezia furfur in psoriasis: modu lation of TGF-beta1, integrin, and HSP70 expression in human keratinocytes and in the skin of psoriasis-affected patients. (14675283)	Baroni A.... Donnarumma G.	2004	JUN
30	HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes. (14675183)	Suomela S.... Saarialho-Kere U.	2003	IFNG, HLA-C, CCHCR1
31	Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients. (12505198)	L/uszczek W.... Kusnierczyk P.	2003	HLA-C
32	Psoriasis patients who are homozygous for the HLA-Cw*0602 allele have a 2.5-fold increased risk of developing psoriasis compared with Cw6 heterozygotes. (12588373)	Gudjonsson J.E.... Valdimarsson H.	2003	HLA-C
33	A molecule solves psoriasis? Systemic therapies for psoriasis inducing interleukin 4 and Th2 responses. (12879154)	Ghoreschi K.... RAPcken M.	2003	IL4
34	A Crohn's disease-associated insertion polymorphism (3020insC) in the NOD2 gene is not associated with psoriasis vulgaris, palmo-plantar pustular psoriasis or guttate psoriasis. (12930309)	Young C.... Barker J.N.	2003	NOD2
35	A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (12653732)	Chang Y.T.... Wong C.K.	2003	TNF, POU5F1, HLA-A
36	Lack of association of TNF-238A and -308A in Japanese patients with psoriasis vulgaris, psoriatic arthritis and generalized pustular psoriasis. (12234707)	Nishibu A.... Kaneko F.	2002	TNF
37	Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS1 and candidate loci. (11134234)	Veal C.D.... Trembath R.C.	2001	PSORS7
38	Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. (11310827)	Rottman J.B.... Krueger J.G.	2001	CDH1, ICAM1, ITGA4
39	Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris. (11710947)	Vollmer S.... Prinz J.C.	2001	TRB@
40	Skin CD4+ T cells produce interferon-gamma in vitro in response to streptococcal antigens in chronic plaque psoriasis. (10692120)	Brown D.W.... Fry L.	2000	IL4, IFNG, IL10
41	Plasma level of IL-8 in patients with psoriasis and i ts correlation with psoriasis area and severity index and the clinical type of the disease. (11482084)	Pietrzak A.... KozioA8-Montewka M.	2000	IL8
42	Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. (10459139)	Saurat J.H.	1999	RARA, NR1H2
43	Vitamin D receptor polymorphism is associated with psoriasis. (9886274)	Park B.S.... Kim I.G.	1999	VDR
44	Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis. (10235634)	Steinhoff M.... Schmidt W.E.	1999	ADCYAP1, ADCYAP1R1
45	Evidence that a locus for familial psoriasis maps to chromosome 4q. (8841203)	Matthews D.... Williamson R.	1996	PSORS2, PSORS3
46	Serum levels of IL-6 in mycosis fungoides, psoriasis, and lichen planus. (7668549)	Toruniowa B.... Pietrzak A.	1995	IL6
47	Endothelial cell adhesion molecules in psoriasis. (7535517)	Lee M.L.... Schrieber L.	1994	ICAM1, SELE
48	Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. (1702929)	Nickoloff B.J.... Dixit V.M.	1991	TNF, IL8, TGFA
49	Immunologic mechanisms in psoriasis. (16788621)	Gottlieb A.B.	1990	IL6, IFNG
50	Epidermal growth factor/transforming growth factor alpha receptors and psoriasis. (2230197)	King L.E.... Nanney L.B.	1990	EGF, TGFA

Genes related to psoriasis according to GeneCards:

(show top 50)    (show all 679)

id	Symbol	Description	Score	GeneCards Section Context
1	FABP5	fatty acid binding protein 5 (psoriasis-associated)	11.1	Transcripts, Publications, Aliases & Descriptions, Orthologs (show all 5 sections) Summaries
2	PSORS1C1	psoriasis susceptibility 1 candidate 1	11.1	Publications, Aliases & Descriptions, Proteins, Orthologs (show all 5 sections) Summaries
3	PSORS1C2	psoriasis susceptibility 1 candidate 2	11.0	Publications, Transcripts, Aliases & Descriptions, Proteins (show all 5 sections) Orthologs
4	IL20	interleukin 20	11.0	Publications, Functions, Summaries
5	S100A7	S100 calcium binding protein A7	11.0	Functions, Publications, Summaries
6	IL20RA	interleukin 20 receptor, alpha	11.0	Publications, Summaries
7	LYNX1	Ly6/neurotoxin 1	11.0	Publications, Summaries
8	IL17A	interleukin 17A	11.0	Publications, Summaries
9	AREG	amphiregulin	11.0	Publications, Summaries
10	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications, Functions, Summaries
11	PSORS1C3	psoriasis susceptibility 1 candidate 3 (non-protein coding)	11.0	Transcripts, Publications, Aliases & Descriptions
12	PRINS	psoriasis associated non-protein coding RNA induced by stress	11.0	Publications, Aliases & Descriptions
13	IL21	interleukin 21	11.0	Publications, Summaries
14	SLC12A8	solute carrier family 12 (potassium/chloride transporters), member 8	11.0	Publications, Summaries
15	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	11.0	Summaries
16	FLG2	filaggrin family member 2	11.0	Aliases & Descriptions
17	PSORS11	Psoriasis susceptibility 11	11.0	Aliases & Descriptions
18	PSORS3	psoriasis susceptibility 3	11.0	Publications, Aliases & Descriptions
19	PSORS10	psoriasis susceptibility 10	11.0	Publications, Aliases & Descriptions
20	PSORS7	psoriasis susceptibility 7	11.0	Publications, Aliases & Descriptions
21	PSORS8	psoriasis susceptibility 8	11.0	Aliases & Descriptions, Publications
22	PSORS1	psoriasis susceptibility 1	11.0	Publications, Aliases & Descriptions
23	PSORS5	psoriasis susceptibility 5	11.0	Publications, Aliases & Descriptions, Functions
24	PSORS6	psoriasis susceptibility 6	11.0	Publications, Aliases & Descriptions
25	PSORS2	psoriasis susceptibility 2	11.0	Publications, Aliases & Descriptions
26	PSORS4	psoriasis susceptibility 4	11.0	Publications, Aliases & Descriptions
27	PSORS9	psoriasis susceptibility 9	11.0	Aliases & Descriptions, Publications
28	CDSN	corneodesmosin	11.0	Publications, Functions
29	HLA-C	major histocompatibility complex, class I, C	11.0	Publications, UniProt Related
30	IL23R	interleukin 23 receptor	11.0	Publications
31	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.0	Publications
32	PI3	peptidase inhibitor 3, skin-derived	11.0	Publications
33	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
34	TNF	tumor necrosis factor	11.0	Publications
35	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
36	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
37	ELANE	elastase, neutrophil expressed	11.0	Publications
38	TRB@	T cell receptor beta locus	11.0	Publications
39	KRT16	keratin 16	10.9	Publications
40	CCHCR1	coiled-coil alpha-helical rod protein 1	10.9	UniProt Related, Publications
41	IL23A	interleukin 23, alpha subunit p19	10.9	Publications
42	IL17B	interleukin 17B	10.9	Publications
43	S100A7A	S100 calcium binding protein A7A	10.9	Expressions, Functions
44	IL22	interleukin 22	10.9	Publications
45	IFN1@	interferon, type 1, cluster	10.9	Publications
46	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	10.9	Publications
47	IL31	interleukin 31	10.9	Publications
48	KRT10	keratin 10	10.9	Publications
49	LOR	loricrin	10.9	Publications
50	RNASE7	ribonuclease, RNase A family, 7	10.9	Publications

Pathways related to psoriasis according to GeneDecks:

(show top 50)    (show all 187)

id	Pathway	Score	Top Affiliating Genes
1	p38 Signaling36	20.0	KITLG, VEGFC, LIF, KDR, BCL2, BAX
2	Tec Kinases Signaling36	19.5	KITLG, VEGFC, BCL2, BAX, JAK1, JAK2
3	Molecular Mechanisms of Cancer36	17.9	KITLG, VEGFC, RARA, RARB, RAF1, LIF
4	MAPK Family Pathway36	17.7	KITLG, VEGFC, RAF1, KDR, BCL2, BAX
5	Immune System38	17.2	KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DS1
6	ERK Signaling36	17.1	KITLG, VEGFC, RAF1, CD2, CD80, ITGA1
7	PAK Pathway36	16.8	KITLG, VEGFC, LIF, KDR, BCL2, BAX
8	PEDF Induced Signaling36	16.6	RAF1, LIF, BCL2, BCL2L1, BAX, CFLAR
9	JAK-STAT Pathway36	16.2	KITLG, VEGFC, RAF1, KDR, BCL2, UBC
10	MIF Mediated Glucocorticoid Regulation36	16.2	LIF, BCL2, BAX, CD2, CD14, CD80
11	MIF Regulation of Innate Immune Cells36	16.0	LIF, BCL2, BAX, JUN, CD2, CD14
12	IL-6 Pathway36	15.5	RAF1, BAX, CD2, CD80, IL10, IL11
13	Regulation of eIF4 and p70S6K36	15.5	VEGFC, BAX, CD2, CD4, CD80, ITGA1
14	Jak-STAT signaling pathway20	15.4	BCL2L1, LEP, JAK1, JAK2, IL10, IL10RA
15	Natural killer cell mediated cytotoxicity20	14.8	KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4
16	Chemokine Signaling36	14.5	JUN, JAK2, IL8, MAPK3, MAPK14, MAPK1
17	Rheumatoid arthritis20	14.4	VEGFA, JUN, CD28, CD86, CD80, ITGAL
18	Tuberculosis20	14.2	VDR, RAF1, BCL2, CIITA, BAX, JAK1
19	Hematopoietic cell lineage20	13.9	KITLG, CD2, CD36, CD8A, CD14, CD59
20	THC Differentiation Pathway36	13.3	CD28, CD86, IL10, IL10RA, IL12A, IL12B
21	Graft-versus-host disease20	13.3	KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5A, KIR2DL2
22	Toll-like receptor signaling pathway20	13.3	JUN, CD86, CD14, CD80, CD40, IRF5
23	Measles20	13.3	MX1, JAK1, JAK2, CD28, CDK2, IRF7
24	Toxoplasmosis20	13.3	BCL2, BCL2L1, CIITA, LDLR, JAK1, JAK2
25	Allograft rejection20	13.2	CD28, CD86, CD40LG, CD80, CD40, GZMB
26	Immune response IL-22 signaling pathway10	13.2	BCL2, BCL2L1, JUN, JAK1, JAK2, CD28
27	Intestinal immune network for IgA production20	13.1	CD28, CD86, CD40LG, CD80, CD40, ITGA4
28	Immune response_IL-22 signaling pathway41	13.1	BCL2, BCL2L1, JUN, JAK1, JAK2, CD28
29	PPAR Pathway36	13.1	KITLG, VEGFC, RAF1, ITGA1, ITGA3, ITGA4
30	Type I diabetes mellitus20	12.9	CD28, CD86, CD80, GZMB, INS, IL12A
31	Malaria20	12.8	LRP1, SELE, SELP, VCAM1, CD36, CD40LG
32	Immune response Role of integrins in NK cells cytotoxicity10	12.8	VCAM1, RAF1, ITGA4, ITGAL, ITGB1, ITGB2
33	Phospholipase-C Pathway36	12.8	KITLG, VEGFC, RAF1, KDR, CD79A, ITGA1
34	Immune response_Role of integrins in NK cells cytotoxicity41	12.8	VCAM1, RAF1, ITGA4, ITGAL, ITGB1, ITGB2
35	Hepatitis C20	12.7	RAF1, CLDN4, CLDN5, CLDN7, CLDN1, LDLR
36	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	12.7	GZMB, IL12B, IL17A, IL17F, IL1B, IL21
37	Cytokine Network36	12.5	IL10, IL12A, IL12B, IL13, IL15, IL18
38	PTEN Pathway36	12.4	KITLG, VEGFC, KDR, ITGA1, ITGA3, ITGA4
39	Chagas disease (American trypanosomiasis)20	12.4	CFLAR, JUN, IL10, IL12A, IL12B, IL1B
40	Asthma20	12.2	CD40LG, CD40, IL10, IL13, IL3, IL4
41	IL-10 Pathway36	12.0	BCL2L1, JAK1, CD14, IL10, IL10RA, IL1A
42	Bacterial infections in CF airways41	11.9	SFTPD, IRF1, IL1R1, IKBKB, CTSL1, TLR1
43	Transcription Role of VDR in regulation of genes involved in osteoporosis10	11.8	VDR, BGLAP, JUN, FOSL1, IL1A, IL1B
44	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	11.5	VDR, BGLAP, JUN, FOSL1, IL1A, IL1B
45	Renin-Angiotensin Pathway36	11.5	KITLG, VEGFC, VCAM1, RAF1, KDR, JUN
46	Apoptotic Pathways in Synovial Fibroblasts36	11.5	KITLG, VEGFC, KDR, CFLAR, FLT1, FLT4
47	Cellular Apoptosis Pathway36	11.4	KITLG, VEGFC, KDR, BCL2, BCL2L1, BAK1
48	Immune response MIF-mediated glucocorticoid regulation10	11.1	VCAM1, JUN, MMP1, MIF, IL2, IL6
49	Angiogenesis3	11.1	VHL, VEGFC, KDR, ITGB1, MMP2, MMP9
50	Mitochondrial Apoptosis36	11.1	KITLG, VEGFC, KDR, BCL2, BCL2L1, BAK1

Compounds related to psoriasis according to GeneDecks:

(show top 50)    (show all 475)

id	Compound	Score	Top Affiliating Genes
1	thymidine32 18	20.4	KITLG, SFTPD, PCNA, SERPINA1, VIP, NAGLU
2	fmlp32	17.6	PDE4A, SELP, SELPLG, SERPINA3, VIM, VCAM1
3	estrogen32	17.1	RETN, PCNA, SERPINC1, SERPINB2, SERPINA1, SERPINA3
4	arachidonic acid32 9 18 9	19.1	PDE4A, CNR1, KITLG, SELP, SERPINA1, VIM
5	hydrogen32 18	16.9	PDE4A, KIR3DL1, SELPLG, SERPINB2, RARA, CIITA
6	genistein32 9 18 9	18.8	KITLG, PCNA, SELE, SELP, VIM, VEGFA
7	wortmannin32 42	16.6	PI3, PDE4A, KITLG, VTN, VIM, VCAM1
8	aspartate32	15.4	RETN, CNR1, VTN, PCNA, SELP, VIM
9	progesterone32 42 9 18 9	18.4	PDE4A, PCNA, SERPINB2, SERPINA3, BSG, VEGFC
10	vitamin d32	14.4	LRP1, VIM, NAGLU, VDR, RARA, RARS
11	threonine32	13.8	SELPLG, RAF1, ZFYVE9, CHRNA7, CD4, FKBP1A
12	prednisolone32 9 9	15.7	KITLG, SFTPD, VIP, VCAM1, BGLAP, MPO
13	aspirin32 34 18	15.2	PDE4A, CNR1, KITLG, VTN, PCNA, SELE
14	polyacrylamide32	13.1	SERPINA1, SERPINA3, LPA, RARA, S100A12, S100A8
15	cuprophan32	13.1	VTN, SELP, SERPINF2, VCAM1, LIF, CD14
16	butyrate32	13.0	ZNF148, KITLG, PCNA, VIM, VDR, RARA
17	gm-csf32	12.9	KITLG, VEGFA, LIF, BCL2L1, CD14, IL10
18	gf 109203x32 42	13.9	KITLG, VEGFA, RAF1, JUN, JAK2, CDKN1A
19	n-formylmethionyl-leucylphenylalanine32	12.8	VTN, SELP, SELPLG, MPO, CD55, ITGAL
20	okt332	12.8	SELE, VCAM1, CD79A, CD40LG, ITGB2, FCER2
21	carbohydrates32	12.8	SFTPD, SELE, SELP, SELPLG, BSG, VCAM1
22	polymyxin b32	12.6	SELE, VCAM1, LDLR, CD14, ITGB2, IL10
23	cytochalasin b32	12.6	VTN, SELPLG, VIM, BSG, BIRC5, S100A9
24	okadaic acid32 42	13.6	SERPINB2, VIM, RAF1, BCL2, BCL2L1, JUN
25	methacholine32 9 9	14.5	VIP, MPO, CD79A, CD14, ITGA4, IL13
26	quercetin32 42 9 18 9	16.2	SELE, VCAM1, RAF1, BIRC5, BCL2, BCL2L1
27	egcg32	12.2	RAF1, BCL2L1, LDLR, CDK2, IVL, IL1A
28	pge132	12.1	PDE4A, VIP, CD40, MMP1, FGA, IL11
29	azathioprine32 34 9 9	15.0	PCNA, VIM, RARB, LIF, BGLAP, MTHFR
30	2,5-oligoadenylate32	12.0	MX1, IRF1, IRF2, IRF7, IL10, IL2
31	flagellin32	12.0	S100A8, CD86, IL18, IL1B, IL8, CCL20
32	verapamil32 34 9 18 9	15.9	LRP1, VIP, NAGLU, LDLR, JAK2, CDH1
33	p00332	11.8	RETN, SERPINA1, LEP, CHI3L1, S100B, CD14
34	manganese superoxide32	11.8	SERPINB2, VCAM1, BCL2L1, CD14, CD40, GSR
35	cyclophosphamide32 34 9 9	14.7	ITGA4, ITGAL, ITGB2, F8, TRB@, LTF
36	erythromycin32 9 9	13.7	VIP, VCAM1, BCL2L1, MPO, CD40LG, ITGB2
37	citrate32	11.5	SELP, NAGLU, VDR, CD79A, MKI67, GUSB
38	staurosporin32	11.5	BCL2, BCL2L1, JUN, ITGAL, IL8, MAPK14
39	carbachol32 9 9	13.5	IL11, F2RL1, PTH, KRIT1, TAC1, ADRB2
40	dmso32	11.4	KITLG, SELP, VIM, S100A9, CD36, MMP3
41	mycophenolate mofetil32 9 9	13.3	SELE, SELP, CD79A, CD36, CD40LG, CD40
42	alpha tocopherol32	11.2	VCAM1, RARB, LIF, BGLAP, LEP, LDLR
43	malondialdehyde32	11.0	NAGLU, LPA, CHAT, MPO, GSR, GSTM1
44	neomycin32	10.9	KITLG, VIM, GUSB, IL13, IL1A, IL3
45	l-nmma32	10.8	VIP, VCAM1, IL1RN, IGHE, CAT, PPARG
46	ciglitazone32	10.6	RARA, RARB, BCL2L1, BAX, JUN, CDKN1A
47	tamoxifen32 34 9 9	13.5	PDE4A, VTN, PCNA, SELE, SERPINC1, VIM
48	arsenite32 18	11.3	PCNA, VEGFA, VDR, RARA, BIRC5, BCL2
49	progestin32	10.2	SERPINC1, VIM, VEGFA, LIF, KDR, CDH1
50	silymarin32	9.7	PCNA, VEGFA, BIRC5, JUN, CDK2, MMP2

Cellular components related to psoriasis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	25.8	LRIG2, CNR1, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
2	extracellular region	GO:005576	22.1	RETN, KITLG, VTN, SFTPD, SERPINC1, SERPINF2
3	cytoplasm	GO:005737	20.7	LRIG2, LRP1, KITLG, PCNA, SELP, SERPINB3
4	extracellular space	GO:005615	20.2	KITLG, VTN, SFTPD, SELE, SELP, SERPINC1
5	integral to plasma membrane	GO:005887	19.5	LRP1, CNR1, KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1
6	external side of plasma membrane	GO:009897	15.5	SELP, VCAM1, KDR, LDLR, CD28, CD79A
7	cytosol	GO:005829	15.1	PDE4A, SERPINB8, VIM, NAT1, NAT2, VHL
8	cell surface	GO:009986	14.0	VEGFA, VCAM1, RARA, LDLR, FZD5, CD36
9	cornified envelope	GO:001533	12.3	CDSN, IVL, ANXA1, LOR, SPRR2A, SPRR2E
10	membrane raft	GO:045121	12.2	SELE, BSG, JAK2, CD79A, CD36, CD14
11	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	11.7	CANX, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1
12	platelet alpha granule lumen	GO:031093	10.1	SERPINF2, SERPINA1, VEGFA, VEGFC, FN1, FGA

Biological processes related to psoriasis according to GeneDecks:

(show top 50)    (show all 73)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	19.8	KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1, KIR3DL1, KIR2DS2
2	inflammatory response	GO:006954	19.3	SELE, SELP, SERPINA3, CHI3L1, S100A12, S100A8
3	signal transduction	GO:007165	17.5	PDE4A, KIR2DL4, KITLG, VEGFC, VDR, RARA
4	chemotaxis	GO:006935	15.1	S100A8, S100A9, FOSL1, FGF2, IL4, MAPK14
5	cell-cell signaling	GO:007267	14.5	S100A9, CD86, CD80, ITGB2, AREGB, INS
6	cytokine-mediated signaling pathway	GO:019221	14.5	VCAM1, CIITA, MX1, UBC, JAK1, JAK2
7	epidermis development	GO:008544	14.4	ZNF750, S100A7, CDSN, FGF7, FABP5, CASP14
8	positive regulation of transcription from RNA polymerase II promoter	GO:045944	14.4	ZNF750, ZNF148, SERPINF2, VEGFA, VDR, RARA
9	regulation of immune response	GO:050776	14.2	KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1, KIR2DS2
10	innate immune response	GO:045087	14.1	SFTPD, BCL2, BCL2L1, LGMN, MX1, UBC
11	response to drug	GO:042493	13.6	PDE4A, VEGFC, BGLAP, BCL2, CHAT, BAK1
12	negative regulation of cell proliferation	GO:008285	13.4	VHL, VDR, RARB, RAF1, RARRES1, RARRES3
13	apoptotic process	GO:006915	13.2	VIM, RAF1, BIRC5, BCL2, BCL2L1, UBC
14	keratinocyte differentiation	GO:030216	13.2	S100A7, CDSN, IVL, FLG, ANXA1, LOR
15	cell surface receptor signaling pathway	GO:007166	13.2	BSG, CD28, CD2, CD36, CD14, CD59
16	interferon-gamma-mediated signaling pathway	GO:060333	13.2	VCAM1, CIITA, JAK1, JAK2, IRF1, IRF2
17	blood coagulation	GO:007596	13.1	SELP, SELPLG, SERPINC1, SERPINF2, SERPINB2, SERPINA1
18	keratinization	GO:031424	13.1	LCE3A, LCE3B, LCE3C, LCE3D, IVL, IL1A
19	virus-host interaction	GO:019048	13.1	VIM, VCAM1, CLDN1, KDR, LDLR, BAX
20	response to lipopolysaccharide	GO:032496	13.0	CNR1, SELE, SELP, SERPINA1, S100A7, S100A8
21	positive regulation of T cell proliferation	GO:042102	12.9	VCAM1, CD28, CD1D, ITGAL, IL12A, IL12B
22	positive regulation of cell proliferation	GO:008284	12.9	VIP, VEGFA, VEGFC, RARA, LIF, BIRC5
23	angiogenesis	GO:001525	12.9	VEGFA, VEGFC, KDR, S100A7, JUN, MMP19
24	positive regulation of angiogenesis	GO:045766	12.8	VEGFA, KDR, CHI3L1, CHRNA7, MMP9, FLT1
25	response to hypoxia	GO:001666	12.8	SERPINA1, VEGFA, VCAM1, RAF1, BCL2, LEP
26	response to organic cyclic compound	GO:014070	12.8	SELP, SERPINA1, BAK1, JUN, JUNB, CDKN1A
27	leukocyte migration	GO:050900	12.7	SELP, SELPLG, BSG, CD58, CD2, CD48
28	positive regulation of ERK1 and ERK2 cascade	GO:070374	12.7	SERPINF2, KDR, CHI3L1, S100A7, FLT4, MIF
29	positive regulation of inflammatory response	GO:050729	12.5	JAK2, IL12B, IL15, IL18, IL2, IL21
30	positive regulation of interferon-gamma production	GO:032729	12.2	FZD5, CD40LG, IL12A, IL12B, IL12RB1, IL12RB2
31	response to ethanol	GO:045471	12.2	CNR1, BGLAP, BCL2, CHAT, BAK1, S100A8
32	wound healing	GO:042060	12.2	RAF1, S100A8, INS, FGF10, FGF2, FGF7
33	peptide cross-linking	GO:018149	12.0	IVL, FN1, ANXA1, LOR, F13A1, SPRR1A
34	platelet activation	GO:030168	11.8	SELP, SERPINF2, SERPINA1, VEGFA, VEGFC, RAF1
35	positive regulation of interleukin-12 production	GO:032735	11.8	CD36, CD40LG, CD40, IL12B, IL23A, IL23R
36	positive regulation of smooth muscle cell proliferation	GO:048661	11.7	SERPINF2, JUN, CDH13, FLT1, IL13, IL6
37	cellular response to lipopolysaccharide	GO:071222	11.6	CD36, CD14, ARG1, IL10, IL12B, IL8
38	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	11.6	UBC, S100A12, S100A4, S100B, CFLAR, CD36
39	positive regulation of tumor necrosis factor production	GO:032760	11.6	JAK2, CD36, CD14, IL12B, IL18, IL23A
40	anti-apoptosis	GO:006916	11.5	SERPINB2, VHL, BIRC5, BCL2, BCL2L1, UBC
41	cellular response to mechanical stimulus	GO:071260	11.3	BAK1, CD40, ITGB1, IRF1, IL13, IL18
42	defense response to Gram-negative bacterium	GO:050829	11.3	SELP, S100A7, CD4, IL12B, IL23A, IL23R
43	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.2	UBC, CD40, INS, IL1B, IL6, IL6R
44	negative regulation of apoptotic process	GO:043066	11.1	VEGFA, RAF1, KDR, BCL2, BCL2L1, LEP
45	positive regulation of cell migration	GO:030335	11.1	VEGFA, KDR, JAK2, CDH13, ITGB1, FLT1
46	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.0	KITLG, VTN, VEGFA, LIF, JAK2, CD36
47	positive regulation of MAPK cascade	GO:043410	11.0	LIF, KDR, LEP, CD36, ITGB1, FLT1
48	platelet degranulation	GO:002576	10.8	SELP, SERPINF2, SERPINA1, VEGFA, VEGFC, CD36
49	positive regulation of protein phosphorylation	GO:001934	10.7	VEGFA, CD40, FNDC1, FLT4, IL1B, ENG
50	positive regulation of nitric oxide biosynthetic process	GO:045429	9.6	JAK2, INS, IL1B, IFNG, ICAM1, HSP90AA1

Molecular functions related to psoriasis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	26.9	TGFB1, PRKD1, PRKCZ, PRTN3, PRKCA, CX3CL1
2	cytokine activity	GO:005125	15.2	CD40LG, IL18, IL19, IL1A, IL1B, IL2
3	receptor activity	GO:004872	13.3	NOTCH1, DARC, TEK, TNFRSF11B, TNFRSF11A, TNFRSF10B
4	chemokine activity	GO:008009	13.0	CCL2, CCL22, CCL27, CCL4L1, CCL4, IL8
5	receptor binding	GO:005102	13.0	PDGFRB, NOS2, TNFSF10, TNC, HLA-G, HLA-B
6	transmembrane signaling receptor activity	GO:004888	12.4	KLRC1, KLRB1, NGFR, DARC, KLRD1, EGFR
7	growth factor activity	GO:008083	12.2	CSF3, CXCL1, OSM, TGFB1, TGFA, HBEGF
8	protein homodimerization activity	GO:042803	11.8	SERPINF2, VEGFA, BIRC5, BCL2, CHRNA7, BAK1
9	enzyme binding	GO:019899	10.1	EGFR, RXRA, NOTCH3, NOTCH1, NOD2, PPARG
10	identical protein binding	GO:042802	10.0	TP63, TP53, HSP90AA1, IGF1R, APOE, APOA1
11	protease binding	GO:002020	10.0	TP53, TNF, TNFAIP3, TNFRSF1A, ELANE, DPP4