MCID: PSR002
MIFTS: 60

Psoriasis malady

Skin diseases category

Summaries for Psoriasis

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Sources:
42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people who have psoriasis also get a form of arthritis called psoriatic arthritis. a problem with your immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in your skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because your cells rise too fast. psoriasis can be hard to diagnose because it can look like other skin diseases. your doctor might need to look at a small skin sample under a microscope. psoriasis can last a long time, even a lifetime. symptoms come and go. things that make them worse include infections stress dry skin certain medicines psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medicines, and light therapy. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Psoriasis is related to arthritis and psoriatic arthritis. An important gene associated with Psoriasis is PSORS1C1 (psoriasis susceptibility 1 candidate 1), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The drugs cyclosporine and hydroxyurea and the compounds pge2 and allopurinol have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

NIH Rare Diseases:42 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. the skin on the elbows, knees, scalp, back, face, palms and feet is most often affected, but other parts of the body can be affected as well. a problem with the immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in the skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because the cells rise too fast. although symptoms may come and go, for many, psoriasis is a lifelong condition. infections, stress, dry skin and certain medications may make symptoms worse. psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medications and light therapy. last updated: 2/12/2010

CDC:3 Psoriasis is a chronic, autoimmune skin disease that speeds up the growth cycle of skin cells.

Wikipedia:63 Psoriasis (pronounced /sɵˈraɪ.əsɨs/; from Greek ψωρίασις, meaning \"itching condition\" or... more...

Aliases & Classifications for Psoriasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

psoriasis 8 42 20 22 10 44 33 60


External Ids:

Disease Ontology8 DOID:8893
ICD9CM27 696.5
ICD1025 L40, L40.9

Related Diseases for Psoriasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Psoriasis:



Diseases related to psoriasis

Clinical Features for Psoriasis

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Genetic Tests for Psoriasis

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20GeneTests, 22GTR
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Genetic tests related to Psoriasis:

id Genetic test Affiliating Genes
1 Psoriasis20 22

Anatomical Context for Psoriasis

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32MalaCards
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MalaCards organs/tissues related to Psoriasis:

32
Skin, T cells, Endothelial, Monocytes, Liver, Thyroid, Testes, Lung, Bone, Heart, Tongue, Bone marrow, Kidney, Eye, Tonsil, Colon, Pituitary, B cells, Myeloid, Thymus

Animal Models for Psoriasis or affiliated genes

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Publications for Psoriasis

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Sources:
50PubMed
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Articles related to Psoriasis:

(show top 50)    (show all 2518)
idTitleAuthorsYear
1
Subclinical cardiovascular disease in plaque psoriasis: Association or causal link? (24401219)
2014
2
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting. (23908546)
2013
3
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. (23988587)
2013
4
New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast. (23569359)
2013
5
Deep vein thrombosis and lung cancer in a patient with psoriasis under anti-tumor necrosis factor treatment: a case study. (23879231)
2013
6
Comparative analysis of the use of complementary and alternative medicine by Korean patients with androgenetic alopecia, atopic dermatitis and psoriasis. (22620682)
2013
7
Clinical and psychological characteristics of patients with psoriasis reporting various frequencies of pruritus. (24261840)
2013
8
Fatal Case of Toxic Epidermal Necrolysis Caused by Cefozopran and Associated with Psoriasis. (24048229)
2013
9
Sarcoidosis and psoriasis: a case series and review of the literature exploring co-incidence vs coincidence. (23783749)
2013
10
Psoriasis and psoriatic arthritis video project: an update from the 2010 GRAPPA annual meeting. (22298271)
2012
11
Pustular psoriasis precipitated by cytomegalovirus infection. (22564254)
2012
12
Study of genetic polymorphisms in the tumor necrosis factor I+ promoter region in Spanish patients with psoriasis]. (22188951)
2012
13
Acute respiratory distress syndrome as a complication of generalized pustular psoriasis. (21738981)
2011
14
IgA pemphigus and pustular psoriasis: a possible relation. (21233060)
2011
15
Pemphigus vulgaris with plaque-type psoriasis successfully treated with cyclosporine monotherapy. (21668035)
2011
16
Generalized pustular psoriasis-like dermatophytosis due to Trichophyton rubrum. (21933649)
2011
17
Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. (21848462)
2011
18
LCE3C_LCE3B-del genotype and psoriasis: a summative meta-analysis. (20624365)
2010
19
Epidermolysis bullosa acquisita associated with psoriasis. (20526561)
2010
20
Management of moderate to severe plaque psoriasis (part I): clinical update on antitumor necrosis factor agents. (19213230)
2009
21
Overexpression of vascular endothelial growth factor (VEGF) receptors on keratinocytes in psoriasis: regulated by calcium independent of VEGF. (18419602)
2008
22
A biological approach in a patient with psoriasis and bullous pemphigoid associated with losartan therapy. (18021271)
2008
23
Genome-wide association scan in psoriasis: new insights into chronic inflammatory disease. (20476959)
2008
24
Expression of GLUT-1 in psoriasis and the relationship between GLUT-1 upregulation induced by hypoxia and proliferation of keratinocyte growth. (18565734)
2008
25
Association between the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and risk for psoriasis in a Chinese population in Taiwan. (17263818)
2007
26
Genetics of psoriasis and psoriatic arthritis. (17828355)
2007
27
Psoriasis induced by tumor necrosis factor-alpha antagonist therapy: a case series. (17013997)
2007
28
Activation of dendritic antigen-presenting cells expressing common heat shock protein receptor CD91 during induction of psoriasis. (15948984)
2005
29
Bullous pemphigoid on psoriasis lesions after UVA radiation. (16396821)
2005
30
Generalized pustular psoriasis complicated by acute respiratory distress syndrome. (14996110)
2004
31
Development of pemphigus herpetiformis in a patient with psoriasis receiving UV-light treatment. (15005694)
2004
32
Paradoxical exacerbation of psoriasis in AIDS: proposed explanations including the potential roles of substance P and gram-negative bacteria. (15115314)
2004
33
Association of insertion/deletion polymorphism of the angiotensin-converting enzyme gene with psoriasis. (15491418)
2004
34
Pulmonary alveolar proteinosis associated with psoriasis and complicated by mycobacterial infection: successful treatment with granulocyte-macrophage colony stimulating factor after a partial response to whole lung lavage. (15497254)
2004
35
Serum TNF-alpha in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene. (15119959)
2004
36
Effect of PTU on IL-12 and IL-10 in psoriasis. (14711144)
2003
37
Polymorphisms of tumor necrosis factor (TNF) alpha and beta genes in Korean patients with psoriasis. (12709814)
2003
38
Treatment of psoriatic arthritis and psoriasis vulgaris with the tumor necrosis factor inhibitor infliximab. (12426660)
2002
39
The Mad1 transcription factor is a novel target of activin and TGF-beta action in keratinocytes: possible role of Mad1 in wound repair and psoriasis. (11709721)
2001
40
T-lymphocyte chemotaxis to IL-8 in patients with psoriasis in vitro. (10374381)
1998
41
Generalized pustular psoriasis in Japan: two distinct groups formed by differences in symptoms and genetic background. (8721499)
1996
42
Rheological analysis of peripheral blood neutrophils in a patient with cutaneous and arthropathic psoriasis accompanying hypopyon-iridocyclitis. (8713013)
1996
43
Coexistence of superficial pemphigus and psoriasis. (8804843)
1996
44
Pemphigus foliaceus coexisting with IgA nephropathy in a patient with psoriasis vulgaris. (8543414)
1995
45
PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy. (7516410)
1994
46
Pustular vasculitis with clinical feature of pustular psoriasis and sternoclavicular hyperostosis. (8453151)
1993
47
The role of streptococcal infection in the initiation of guttate psoriasis. (1739285)
1992
48
Acantholytic dyskeratotic epidermal naevus in a patient with guttate psoriasis on PUVA therapy. (2064947)
1991
49
Increased IL-6 production by monocytes and keratinocytes in patients with psoriasis. (2056189)
1991
50
The eosinophil granulocyte in psoriasis. (2317447)
1990

Genetic Variations for Psoriasis

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Expression for genes affiliated with Psoriasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psoriasis

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Pathways for genes affiliated with Psoriasis

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51QIAGEN, 29KEGG
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Compounds for genes affiliated with Psoriasis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Psoriasis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pge24411.1ALOX5AP, IL17A, AREG, CCL2
2allopurinol44 49 1112.9PSORS1C2, PSORS1C3, PSORS1C1
3actinomycin d4410.8CCL2, AREG, IL17A, ALOX5AP

GO Terms for genes affiliated with Psoriasis

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16Gene Ontology
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Biological processes related to Psoriasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:04567210.8IL17A, IL20

Products for genes affiliated with Psoriasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Psoriasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet