MCID: PSR002
MIFTS: 54

Psoriasis malady

Genetic diseases, Rare diseases, Skin diseases categories

Summaries for Psoriasis

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MedlinePlus:32 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people who have psoriasis also get a form of arthritis called psoriatic arthritis. a problem with your immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in your skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because your cells rise too fast. psoriasis can be hard to diagnose because it can look like other skin diseases. your doctor might need to look at a small skin sample under a microscope. psoriasis can last a long time, even a lifetime. symptoms come and go. things that make them worse include infections stress dry skin certain medicines psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medicines, and light therapy. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Psoriasis is related to psoriatic arthritis and atopic dermatitis. An important gene associated with Psoriasis is PSORS1C1 (psoriasis susceptibility 1 candidate 1), and among its related pathways are Jak-STAT signaling pathway and TGF-Beta Pathway. The drugs anthralin and betamethasone and the compounds rantes and groalpha have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial, and related mouse phenotype immune system.

NIH Rare Diseases:41 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. the skin on the elbows, knees, scalp, back, face, palms and feet is most often affected, but other parts of the body can be affected as well. a problem with the immune system causes psoriasis. in a process called cell turnover, skin cells that grow deep in the skin rise to the surface. normally, this takes a month. in psoriasis, it happens in just days because the cells rise too fast. although symptoms may come and go, for many, psoriasis is a lifelong condition. infections, stress, dry skin and certain medications may make symptoms worse. psoriasis usually occurs in adults. it sometimes runs in families. treatments include creams, medications and light therapy. last updated: 2/12/2010

CDC:3 Psoriasis is a chronic autoimmune skin disease that speeds up the growth cycle of skin cells.

Wikipedia:63 Psoriasis (/s??ra?.?s?s/; from Greek ????????, meaning \"itching condition\" or \"being itchy\", from... more...

Aliases & Classifications for Psoriasis

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Psoriasis, Aliases & Descriptions:

Name: Psoriasis 9 41 20 11 43 22 32 3 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:8893
ICD9CM27 696.5
ICD1025 L40, L40.9

Related Diseases for Psoriasis

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Diseases in the Psoriasis family:

Psoriasis 2

Diseases related to Psoriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 377)
idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis32.0FBXL19, HLA-C
2atopic dermatitis31.5CCL2, IL17A, S100A7
3psoriasis susceptibility 131.4HLA-C
4skin disease31.2AREG, S100A7, IL17A, FABP5, HLA-C
5rheumatoid arthritis30.8AREG, ALOX5AP, IL17A, IL21, CCL2
6uveitis30.7HLA-C, CCL2, IL17A
7inflammatory bowel disease30.7AREG, IL17A, IL21, CCL2
8glomerulonephritis30.6AREG, ALOX5AP, CCL2
9demyelinating disease30.4IL17A, CCL2
10pneumonia30.2ALOX5AP, IL17A, CCL2
11coronary artery disease30.1ALOX5AP, IL17A, CCL2
12asthma30.1CCL2, IL17A, ALOX5AP, AREG
13arthritis11.0
14guttate psoriasis10.8
15dermatitis10.8
16endotheliitis10.5
17bullous pemphigoid10.5
18alopecia10.5
19trachoma10.5S100A7
20hepatitis10.4
21psoriasis 14, pustular10.4
22hypersensitivity syndrome, carbamazepine-induced10.4HLA-C, PSORS1C1
23crohn's disease10.4
24pemphigus10.4
25alopecia areata10.4
26obesity10.4
27pityriasis rubra pilaris10.4
28acne10.4
29lichen planus10.4
30blindness10.4
31pustulosis palmaris et plantaris10.4
32porokeratosis10.3
33thyroiditis10.3
34hypersensitivity reaction type ii disease10.3HLA-C, CCL2, IL17A
35multiple sclerosis, disease progression, modifier of10.3IL17A, CCL2, HLA-C
36spondylitis10.3
37pulmonary disease, chronic obstructive10.3AREG, IL17A, CCL2
38central nervous system disease10.3IL17A, CCL2
39contact dermatitis10.3
40lupus erythematosus10.3
41acute generalized exanthematous pustulosis10.3
42allergic asthma10.3ALOX5AP, IL17A, CCL2
43impetigo herpetiformis10.3
44scabies10.3
45hepatitis b10.2
46mycosis fungoides10.2
47pemphigus foliaceus10.2
48enthesopathy10.2
49pityriasis rosea10.2
50acrodermatitis10.2

Graphical network of the top 20 diseases related to Psoriasis:



Diseases related to psoriasis

Symptoms for Psoriasis

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Genetic Tests for Psoriasis

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Genetic tests related to Psoriasis:

id Genetic test Affiliating Genes
1 Psoriasis20 22

Anatomical Context for Psoriasis

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MalaCards organs/tissues related to Psoriasis:

31
Skin, T cells, Endothelial, Neutrophil, Monocytes, Liver, Thyroid, Tongue, Testes, Bone, Lung, Heart, Tonsil, Pituitary, Bone marrow, Kidney, Eye, Colon, Ovary, Myeloid, B cells

Animal Models for Psoriasis or affiliated genes

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MGI Mouse Phenotypes related to Psoriasis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.2AREG, ALOX5AP, IL20RA, IL17A, IL21, CCL2

Publications for Psoriasis

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Articles related to Psoriasis:

(show top 50)    (show all 2665)
idTitleAuthorsYear
1
Association of psoriasis and/or psoriatic arthritis with autoimmune diseases: the experience of two Italian integrated Dermatology/Rheumatology outpatient clinics. (25882399)
2015
2
A possible role of polycystic ovary syndrome for pregnancy complications in women with psoriasis. (25381981)
2014
3
Nail Psoriasis, the unknown burden of disease. (24422908)
2014
4
Management of psoriasis in patients treated with anti-TNF-I+ therapy for inflammatory bowel disease. (23972498)
2013
5
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting. (23908546)
2013
6
Influence of neutralizing antibodies to adalimumab and infliximab on the treatment of psoriasis. (24329764)
2013
7
Polymorphic pityriasis rosea precipitating psoriasis. (23437430)
2013
8
Cardiometabolic profile, clinical features, quality of life and treatment outcomes in patients with moderate-to-severe psoriasis and psoriatic arthritis. (24283931)
2013
9
NF-I_B: an essential transcription factor in psoriasis. (23219896)
2013
10
Interferon-I^ release assay for tuberculosis in patients with psoriasis treated with tumour necrosis factor antagonists: in vivo and in vitro analysis. (23909256)
2013
11
Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis? (23497068)
2013
12
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. (24211183)
2013
13
Psoriasis and psoriatic arthritis video project: an update from the 2010 GRAPPA annual meeting. (22298271)
2012
14
Power of crowdsourcing: novel methods of data collection in psoriasis and psoriatic arthritis. (22818792)
2012
15
A case of psoriasis with secondary amyloidosis, associated symbrachydactyly of the hand and a transverse deficiency of the foot. (22953651)
2012
16
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (21839423)
2011
17
A novel splicing variant of CADM2 as a protective transcript of psoriasis. (21864505)
2011
18
Erythema multiforme during anti-tumor necrosis factor treatment for plaque psoriasis. (19913942)
2010
19
Expression, localisation and functional activation of NFAT-2 in normal human skin, psoriasis, and cultured keratocytes. (19684889)
2009
20
Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes. (19587699)
2009
21
Management of moderate to severe plaque psoriasis (part I): clinical update on antitumor necrosis factor agents. (19213230)
2009
22
Goeckerman's therapy for psoriasis with special reference to serum pentraxin 3 level. (18986345)
2008
23
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. (18700910)
2008
24
Investigation of +405 and -460 polymorphisms of vascular endothelial growth factor in psoriasis and short-term responsiveness to efalizumab therapy. (18583913)
2008
25
Combined effects of HLA-Cw6, body mass index and waist-hip ratio on psoriasis vulgaris in Chinese Han population. (18585007)
2008
26
Immune-mediated inflammatory diseases and psoriasis]. (18466796)
2008
27
Variants in the 5q31 cytokine gene cluster are associated with psoriasis. (18075513)
2008
28
Polymorphisms in the interferon regulatory factor-1 promoter are not associated with psoriasis and do not influence IFN-alpha-induced Th1 polarization. (17970693)
2007
29
Unraveling the paradoxes of HIV-associated psoriasis: a review of T-cell subsets and cytokine profiles. (17498423)
2007
30
Clinical relevance of nerve growth factor serum levels in patients with atopic dermatitis and psoriasis. (17579279)
2007
31
Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population. (17714919)
2007
32
Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes. (16965413)
2006
33
Effect of psoriasis activity on metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in plasma and lesional scales. (16585983)
2006
34
Effect of psoriasis treatment on plasma concentrations of metalloproteinase-1 and tissue inhibitor of metalloproteinases-1. (15987285)
2005
35
Punctate palmoplantar keratoderma (Buschke-Fischer-Brauer disease) with psoriasis: a rare association showing excellent response to acitretin. (16167422)
2005
36
Biology of tumor necrosis factor-alpha- implications for psoriasis. (15086336)
2004
37
Efalizumab in the treatment of psoriasis. (15379774)
2004
38
Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris. (15140215)
2004
39
Role of NGF and neurogenic inflammation in the pathogenesis of psoriasis. (14699978)
2004
40
Elevated plasma levels of vascular endothelial growth factor and plasminogen activator inhibitor-1 decrease during improvement of psoriasis. (12540021)
2002
41
Clinical and immunologic assessment of patients with psoriasis in a randomized, double-blind, placebo-controlled trial using recombinant human interleukin 10. (12374540)
2002
42
Polymorphisms in inflammation genes (angiotensinogen, TAP1 and TNF-beta) in psoriasis. (11194890)
2000
43
Changes in keratin 6 and keratin 10 (co-)expression in lesional and symptomless skin of spreading psoriasis. (10971053)
2000
44
Polymorphisms of HLA-DM genes in Japanese patients with psoriasis vulgaris. (10417524)
1999
45
Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene. (10545595)
1999
46
The chemotactic activity of T-lymphocytes in response to interleukin 8 is significantly decreased in patients with psoriasis and atopic dermatitis. (9028795)
1996
47
Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. (8034808)
1994
48
Activity of beta-glucuronidase and acid phosphatase in fractions of granulocytes isolated from PMNL in peripheral blood of patients with psoriasis]. (8090655)
1993
49
Mast cell degranulation in the evolution of acute eruptive guttate psoriasis vulgaris. (6512269)
1984
50
Exfoliative dermatitis after undecylenic acid therapy for psoriasis. (14774148)
1950

Variations for Psoriasis

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Expression for genes affiliated with Psoriasis

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Search GEO for disease gene expression data for Psoriasis.

Pathways for genes affiliated with Psoriasis

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Compounds for genes affiliated with Psoriasis

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Sources:
43Novoseek
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Compounds related to Psoriasis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1rantes4310.0IL17A, IL21, CCL2
2groalpha439.9IL17A, CCL2
3actinomycin d439.8AREG, ALOX5AP, IL17A, CCL2
4prostaglandin439.8IL17A, ALOX5AP, AREG
5pge2439.7AREG, ALOX5AP, IL17A, CCL2

GO Terms for genes affiliated with Psoriasis

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Cellular components related to Psoriasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056159.7IL20, IL17A, IL21, MICA, CCL2
2extracellular regionGO:00055769.1S100A7, HLA-C, LYNX1, PSORS1C2, CCL2, IL20

Biological processes related to Psoriasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoclast differentiationGO:004567210.2IL20, IL17A
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.2IL20, IL21
3response to heatGO:000940810.1MICA, CCL2
4cellular response to interleukin-1GO:007134710.1CCL2, IL17A
5cytokine-mediated signaling pathwayGO:00192219.7IL20RA, CCL2, HLA-C

Molecular functions related to Psoriasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:000512510.0IL20, IL17A, IL21

Products for genes affiliated with Psoriasis

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Sources for Psoriasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet