PSORS1
MCID: PSR004
MIFTS: 32

Psoriasis Susceptibility 1 (PSORS1) malady

Categories: Genetic diseases, Skin diseases

Aliases & Classifications for Psoriasis Susceptibility 1

Aliases & Descriptions for Psoriasis Susceptibility 1:

Name: Psoriasis Susceptibility 1 54 29 13
Psoriasis Vulgaris 66 69
Psoriasis 66 69
Psoriasis 1 66
Psors1 66
Pv 66

Characteristics:

HPO:

32
psoriasis susceptibility 1:
Inheritance multifactorial inheritance


Classifications:



External Ids:

OMIM 54 177900
MedGen 40 C1867449
MeSH 42 D011565
ICD10 33 L40.0

Summaries for Psoriasis Susceptibility 1

OMIM : 54 Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the... (177900) more...

MalaCards based summary : Psoriasis Susceptibility 1, also known as psoriasis vulgaris, is related to polycythemia vera, somatic and persistent vegetative state, and has symptoms including arthritis, nail pits and onycholysis. An important gene associated with Psoriasis Susceptibility 1 is HLA-C (Major Histocompatibility Complex, Class I, C). The drugs Dapsone and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include skin and liver.

UniProtKB/Swiss-Prot : 66 Psoriasis 1: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.

Related Diseases for Psoriasis Susceptibility 1

Diseases in the Psoriasis Susceptibility 1 family:

Psoriasis Susceptibility 13

Diseases related to Psoriasis Susceptibility 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 polycythemia vera, somatic 11.7
2 persistent vegetative state 11.1
3 pulmonary valve stenosis 10.9
4 psoriasis 14, pustular 10.9
5 psoriasis, protection against 10.8
6 porphyria variegata 10.8
7 psoriasis susceptibility 13 10.8
8 psoriasis 2 10.8
9 pemphigus vulgaris, familial 10.7
10 plummer vinson syndrome 10.7
11 polycythemia 10.1
12 essential thrombocythemia 10.0
13 pemphigus 9.9
14 autosomal recessive congenital methemoglobinemia 9.9 HLA-C PSORS1C1
15 myelofibrosis 9.9
16 pemphigus vulgaris 9.9
17 epidermodysplasia verruciformis 9.8
18 hamanishi ueba tsuji syndrome 9.8 CDSN HLA-C
19 goodpasture syndrome 9.8 HLA-C JAK2
20 psoriasis 9.8
21 endophthalmitis 9.7
22 thyroiditis 9.7
23 bacteremia 9.7
24 anencephaly 9.6
25 ovarian cancer 9.6
26 adult respiratory distress syndrome 9.6
27 leukemia 9.6
28 neuroblastoma 9.6
29 cutaneous lupus erythematosus 9.6
30 bullous pemphigoid 9.6
31 malaria 9.6
32 atrial fibrillation 9.6
33 herpes zoster 9.6
34 dermatomyositis 9.6
35 myeloid leukemia 9.6
36 mastitis 9.6
37 lupus erythematosus 9.6
38 primary polycythemia 9.6
39 rabies 9.6
40 cardiac tamponade 9.6
41 keratitis 9.6
42 plasmodium vivax malaria 9.6
43 uterine fibroid 9.6
44 pemphigus vegetans 9.6
45 pericarditis 9.6
46 atrophic gastritis 9.3 CDSN HLA-C PSORS1C1 PSORS1C2 PSORS1C3
47 sarcoidosis 1 9.1 CDSN HLA-C JAK2 PSORS1C1 PSORS1C2 PSORS1C3

Graphical network of the top 20 diseases related to Psoriasis Susceptibility 1:



Diseases related to Psoriasis Susceptibility 1

Symptoms & Phenotypes for Psoriasis Susceptibility 1

Symptoms by clinical synopsis from OMIM:

177900

Clinical features from OMIM:

177900

Human phenotypes related to Psoriasis Susceptibility 1:

32
id Description HPO Frequency HPO Source Accession
1 arthritis 32 HP:0001369
2 nail pits 32 HP:0001803
3 onycholysis 32 HP:0001806
4 psoriasis 32 HP:0003765

UMLS symptoms related to Psoriasis Susceptibility 1:


exanthema, pruritus, psoriasiform rash

Drugs & Therapeutics for Psoriasis Susceptibility 1

Drugs for Psoriasis Susceptibility 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Phase 4 80-08-0 2955
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Antimalarials Phase 4
7 Antiparasitic Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Folic Acid Antagonists Phase 4
10 Vitamin B Complex Phase 4
11 Folate Nutraceutical Phase 4
12 Vitamin B9 Nutraceutical Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4
2 Evaluate the Effect of Elimune Capsules Completed NCT02251678 Phase 1
3 Effect of Atopic Diathesis as Assessed by Serum Th1/Th2 Cytokine Profile on Clinical Manifestation of Psoriasis Unknown status NCT00372580
4 The Impact of Targeted Therapy on Microorganism in Patients With Psoriasis Unknown status NCT01504113

Search NIH Clinical Center for Psoriasis Susceptibility 1

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Psoriasis Susceptibility 1

Genetic tests related to Psoriasis Susceptibility 1:

id Genetic test Affiliating Genes
1 Psoriasis Susceptibility 1 29

Anatomical Context for Psoriasis Susceptibility 1

MalaCards organs/tissues related to Psoriasis Susceptibility 1:

39
Skin, Liver

Publications for Psoriasis Susceptibility 1

Articles related to Psoriasis Susceptibility 1:

id Title Authors Year
1
A polymorphism within the psoriasis susceptibility 1 candidate 1 (PSORS1C1) gene is not linked to HLA-B*58:01 in an Australian cohort. ( 26653889 )
2015
2
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. ( 16642438 )
2006

Variations for Psoriasis Susceptibility 1

ClinVar genetic disease variations for Psoriasis Susceptibility 1:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HLA-C HLA-C, HLA-Cw6 undetermined variant risk factor

Expression for Psoriasis Susceptibility 1

Search GEO for disease gene expression data for Psoriasis Susceptibility 1.

Pathways for Psoriasis Susceptibility 1

GO Terms for Psoriasis Susceptibility 1

Biological processes related to Psoriasis Susceptibility 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 8.62 HLA-C JAK2

Sources for Psoriasis Susceptibility 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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