MCID: PSR001
MIFTS: 58

Psoriatic Arthritis malady

Skin diseases, Respiratory diseases, Bone diseases, Rare diseases categories
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Summaries for Psoriatic Arthritis

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MedlinePlus:33 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get them on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people with psoriasis have psoriatic arthritis. it causes pain, stiffness, and swelling of the joints. it is often mild, but can sometimes be serious and affect many joints. the joint and skin problems don't always happen at the same time. your doctor will do a physical exam and imaging tests to diagnose psoriatic arthritis. there is no cure, but medicines can help control inflammation and pain. in rare cases, you might need surgery to repair or replace damaged joints.

MalaCards based summary: Psoriatic Arthritis, also known as arthropathic psoriasis, is related to arthritis and ankylosing spondylitis. An important gene associated with Psoriatic Arthritis is LTA (lymphotoxin alpha), and among its related pathways is Allograft rejection. The drugs auranofin and aurothioglucose and the compounds infliximab and il 10 have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone.

Disease Ontology:8 A syndrome that occurs in humans with psoriasis who also experience symptoms similar to arthritis.

Genetics Home Reference:21 Psoriatic arthritis is a condition involving joint inflammation (arthritis) that usually occurs in combination with a skin disorder called psoriasis. Psoriasis is a chronic inflammatory condition characterized by patches of red, irritated skin that are often covered by flaky white scales. People with psoriasis may also have changes in their fingernails and toenails, such as nails that become pitted or ridged, crumble, or separate from the nail beds.

Wikipedia:65 Psoriatic arthritis (also arthritis psoriatica, arthropathic psoriasis or psoriatic arthropathy) is a... more...

Description from OMIM:46 607507

Aliases & Classifications for Psoriatic Arthritis

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Psoriatic Arthritis, Aliases & Descriptions:

Name: Psoriatic Arthritis 8 21 46 10 33
Arthropathic Psoriasis 8 21 62
Psoriatic Arthropathy 21 62
Psoriatic Arthritis, Susceptibility to 9
 
Arthritis, Psoriatic 62
Arthritis Psoriatica 8
Arthritis Psoriatic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Respiratory diseases, Bone diseases


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Disease Ontology8 DOID:9008
NCIt39 C61277
MeSH34 D015535
ICD9CM27 696.0
ICD1025 L40.5

Related Diseases for Psoriatic Arthritis

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Graphical network of the top 20 diseases related to Psoriatic Arthritis:



Diseases related to psoriatic arthritis

Symptoms for Psoriatic Arthritis

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Clinical features from OMIM:

607507

Drugs & Therapeutics for Psoriatic Arthritis

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Drug clinical trials:

Search ClinicalTrials for Psoriatic Arthritis

Search NIH Clinical Center for Psoriatic Arthritis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Psoriatic Arthritis

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Anatomical Context for Psoriatic Arthritis

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MalaCards organs/tissues related to Psoriatic Arthritis:

32
Skin, Testes, Bone, T cells, Heart, Endothelial, Liver, Thyroid, Monocytes, Neutrophil, Eye, Myeloid, B cells

Animal Models for Psoriatic Arthritis or affiliated genes

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Publications for Psoriatic Arthritis

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Articles related to Psoriatic Arthritis:

(show top 50)    (show all 859)
idTitleAuthorsYear
1
JAK/STAT/PKCI' molecular pathways in synovial fluid T lymphocytes reflect the in vivo T helper-17 expansion in psoriatic arthritis. (24385089)
2014
2
Ultrasound composite scores for the assessment of inflammatory and structural pathologies in Psoriatic Arthritis (PsASon-Score). (25361855)
2014
3
Self-reported adherence to a home-based exercise program among patients affected by psoriatic arthritis with minimal disease activity. (25381979)
2014
4
Ankylosis of Temporomandibular Joint caused by Psoriatic Arthritis: A Report of Four Cases with Literature Review. (25028690)
2014
5
Periarticular bone gain at proximal interphalangeal joints and changes in bone turnover markers in response to tumor necrosis factor inhibitors in rheumatoid and psoriatic arthritis. (23457381)
2013
6
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting. (23908546)
2013
7
Presentation of psoriatic arthritis in the literature: a twenty-year bibliometric evaluation. (22451035)
2013
8
Cardiometabolic profile, clinical features, quality of life and treatment outcomes in patients with moderate-to-severe psoriasis and psoriatic arthritis. (24283931)
2013
9
Prevalence of methotrexate intolerance in rheumatoid arthritis and psoriatic arthritis. (24345416)
2013
10
Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis? (23497068)
2013
11
Serological markers in psoriatic arthritis: promising tools. (24146263)
2013
12
Role of IL-17 in psoriasis and psoriatic arthritis. (22362575)
2013
13
Access to health care in patients with psoriasis and psoriatic arthritis: data from National Psoriasis Foundation survey panels. (23783152)
2013
14
Clinical and demographic factors influence on anxiety and depression in early psoriatic arthritis (ePsA). (23295140)
2013
15
Therapeutic strategies in psoriasis patients with psoriatic arthritis: focus on new agents. (23580094)
2013
16
Potential use of optical coherence tomography and high-frequency ultrasound for the assessment of nail disease in psoriasis and psoriatic arthritis. (23988587)
2013
17
Prologue: 2012 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). (23908533)
2013
18
Obesity and psoriatic arthritis: from pathogenesis to clinical outcome and management. (22989426)
2013
19
Patient education, disease activity and physical function: can we be more targeted? A cross sectional study among people with rheumatoid arthritis, psoriatic arthritis and hand osteoarthritis. (24286444)
2013
20
Entheseal power Doppler ultrasonography: a comparison of psoriatic arthritis and fibromyalgia. (22751587)
2012
21
Psoriasis and psoriatic arthritis video project: an update from the 2010 GRAPPA annual meeting. (22298271)
2012
22
Power of crowdsourcing: novel methods of data collection in psoriasis and psoriatic arthritis. (22818792)
2012
23
Interleukin 6 blockade: tocilizumab in psoriatic arthritis. (22751605)
2012
24
Power Doppler ultrasonographic evaluation of enthesitis in psoriatic arthritis. A multi-center study. (22119348)
2012
25
Psoriatic arthritis: radiographic joint repair following etanercept therapy. (22210679)
2012
26
Psoriatic arthritis: an update. (23209897)
2012
27
Tumor necrosis factor promoter polymorphism TNF*-857 is a risk allele for psoriatic arthritis independent of the PSORS1 locus. (22127698)
2011
28
IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients. (21613309)
2011
29
Heel pain due to psoriatic arthritis in a 50 year old recreational male athlete: case report. (22131565)
2011
30
Synovial tissue response to treatment in psoriatic arthritis. (22279513)
2011
31
Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis. (21281511)
2011
32
Psoriatic arthritis: pharmacoeconomic considerations. (19691929)
2009
33
Cardiovascular risk in psoriatic arthritis]. (19663192)
2009
34
Apolipoprotein A-I and cholesterol in synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis. (19327233)
2009
35
MRI findings of juvenile psoriatic arthritis. (18594809)
2008
36
Coexistence of psoriatic arthritis and collagenous colitis with inflammatory nervous system disease. (18538620)
2008
37
Immunopathogenesis of psoriasis and psoriatic arthritis and pharmacological perspectives. (17828356)
2007
38
Ectopic lymphoid neogenesis in psoriatic arthritis. (17223654)
2007
39
Recommendations of the Italian Society for Rheumatology for the use of biologic (TNF-alpha blocking) agents in the treatment of psoriatic arthritis. (16539822)
2006
40
Prolactin and growth hormone responses to hypoglycemia in patients with systemic sclerosis and psoriatic arthritis. (16855141)
2006
41
Serious pancytopenia from methotrexate treatment of psoriatic arthritis. (16635735)
2006
42
TNFalpha antagonist therapy in ankylosing spondylitis and psoriatic arthritis: recommendations of the French Society for Rheumatology. (16843030)
2006
43
Psoriatic arthritis. (16310398)
2005
44
Cytokine profiles during infliximab monotherapy in psoriatic arthritis. (16120138)
2005
45
Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis. (16255050)
2005
46
Current concepts and new developments in the treatment of psoriatic arthritis. (12810935)
2003
47
Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis. (12421111)
2002
48
Lack of association between promoter polymorphism of the tumor necrosis factor-alpha gene and psoriatic arthritis in Japanese patients. (11121160)
2000
49
Abnormal T-cell function in patients with psoriatic arthritis: evidence for decreased interleukin 2 production. (8310207)
1993
50
The presence of autoantibody to recombinant lipocortin-I in patients with psoriasis and psoriatic arthritis. (2147389)
1990

Variations for Psoriatic Arthritis

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Clinvar genetic disease variations for Psoriatic Arthritis:

6
id Gene Name Type Significance SNP ID Assembly Location
1LTANM_001159740.2(LTA): c.-9-198A> Gsingle nucleotide variantrisk factorrs909253GRCh38Chr 6, 31572536: 31572536

Expression for genes affiliated with Psoriatic Arthritis

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Expression patterns in normal tissues for genes affiliated with Psoriatic Arthritis

Search GEO for disease gene expression data for Psoriatic Arthritis.

Pathways for genes affiliated with Psoriatic Arthritis

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Pathways related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3LTA, KIR2DS1, MICA

Compounds for genes affiliated with Psoriatic Arthritis

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1infliximab44 50 1112.1LTA, NOD2
2il 10449.8LTA, NOD2

GO Terms for genes affiliated with Psoriatic Arthritis

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Biological processes related to Psoriatic Arthritis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.3LTA, NOD2
2positive regulation of interleukin-17 productionGO:03274010.3IL23R, NOD2
3negative regulation of growth of symbiont in hostGO:04413010.3LTA, NOD2
4positive regulation of interleukin-12 productionGO:03273510.2NOD2, IL23R
5defense response to Gram-positive bacteriumGO:05083010.2LTA, NOD2
6positive regulation of interferon-gamma productionGO:03272910.1LTA, IL23R
7response to lipopolysaccharideGO:03249610.0IL23R, NOD2, LTA
8defense responseGO:0069529.8NOD2, TNIP1
9keratinizationGO:0314249.7LCE1C, LCE3B, LCE3C
10defense response to bacteriumGO:0427429.7NOD2, S100A12, MICA
11positive regulation of inflammatory responseGO:0507299.5TNIP1, S100A12
12inflammatory responseGO:0069549.4S100A12, IL23R, TNIP1

Products for genes affiliated with Psoriatic Arthritis

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Sources for Psoriatic Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet