MCID: PSR001
MIFTS: 57

Psoriatic Arthritis malady

Skin diseases category

Summaries for Psoriatic Arthritis

About this section
Sources:
8Disease Ontology, 21Genetics Home Reference, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get them on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people with psoriasis have psoriatic arthritis. it causes pain, stiffness, and swelling of the joints. it is often mild, but can sometimes be serious and affect many joints. the joint and skin problems don't always happen at the same time. your doctor will do a physical exam and imaging tests to diagnose psoriatic arthritis. there is no cure, but medicines can help control inflammation and pain. in rare cases, you might need surgery to repair or replace damaged joints.

MalaCards: Psoriatic Arthritis, also known as arthropathic psoriasis, is related to arthritis and psoriasis. An important gene associated with Psoriatic Arthritis is LTA (lymphotoxin alpha), and among its related pathways are Immune System and PAK Pathway. The drugs auranofin and aurothioglucose and the compound il 10 have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related mouse phenotype immune system.

Disease Ontology:8 A syndrome that occurs in humans with psoriasis who also experience symptoms similar to arthritis.

Genetics Home Reference:21 Psoriatic arthritis is a condition involving joint inflammation (arthritis) that usually occurs in combination with a skin disorder called psoriasis. Psoriasis is a chronic inflammatory condition characterized by patches of red, irritated skin that are often covered by flaky white scales. People with psoriasis may also have changes in their fingernails and toenails, such as nails that become pitted or ridged, crumble, or separate from the nail beds.

Wikipedia:63 Psoriatic arthritis (also arthritis psoriatica, arthropathic psoriasis or psoriatic arthropathy) is a... more...

Description from OMIM:46 607507

Aliases & Classifications for Psoriatic Arthritis

About this section
Sources:
8Disease Ontology, 21Genetics Home Reference, 46OMIM, 10DISEASES, 33MedlinePlus, 9diseasecard, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

psoriatic arthritis 8 21 46 10 33
arthropathic psoriasis 8 21
psoriatic arthritis, susceptibility to 9
psoriatic arthropathy 21
arthritis, psoriatic 60
arthritis psoriatica 8
arthritis psoriatic 44


External Ids:

Disease Ontology8 DOID:9008
ICD9CM27 696.0
NCIt39 C61277
MeSH34 D015535
ICD1025 L40.5

Related Diseases for Psoriatic Arthritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Psoriatic Arthritis family:

Juvenile Psoriatic Arthritis

Diseases related to Psoriatic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.2NOD2, IL23A, LTA, S100A12
2psoriasis31.7LCE3C, LCE3B, S100A12, TNIP1, LTA, CDSN
3rheumatoid arthritis31.4S100A12, TNFRSF12A, LTA, IL12B, IL23A, IL23R
4spondylitis31.2NOD2
5ankylosing spondylitis31.2ERAP1, IL23R
6hepatitis30.5LTA
7crohn's disease30.5NOD2, IL23R
8dermatitis30.2NOD2
9systemic lupus erythematosus30.2NOD2, IL23A, IL12B, LTA
10uveitis30.0NOD2, LTA
11atopic dermatitis30.0LTA, CDSN, IL12B, NOD2
12familial mediterranean fever30.0NOD2
13tuberculosis30.0IL12B, IL23A, NOD2
14hepatitis c30.0IL12B
15nail disease10.6
16reactive arthritis10.6
17osteoarthritis10.5
18synovitis10.5
19obesity10.5
20spondyloarthropathy10.5
21newcastle disease10.4
22atherosclerosis10.4
23osteoporosis10.4
24sapho syndrome10.3
25juvenile rheumatoid arthritis10.3
26enthesopathy10.3
27hyperostosis10.3
28skin disease10.3
29ankylosis10.3
30hyperuricemia10.3
31hepatitis a10.3
32acne10.3
33glomerulonephritis10.3
34juvenile psoriatic arthritis10.3
35relapsing polychondritis10.2
36reflex sympathetic dystrophy10.2
37angioedema10.2
38arthropathy10.2
39iridocyclitis10.2
40leishmaniasis10.2
41lupus erythematosus10.2
42melanoma10.2
43nervous system disease10.2
44pancreatitis10.2
45vasculitis10.2
46fasciitis10.1
47bone fracture10.0
48gout10.0
49bullous pemphigoid10.0
50renal osteodystrophy10.0

Graphical network of the top 20 diseases related to Psoriatic Arthritis:



Diseases related to psoriatic arthritis

Clinical Features for Psoriatic Arthritis

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

607507

Drugs & Therapeutics for Psoriatic Arthritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Psoriatic Arthritis

Drug clinical trials:

Search ClinicalTrials for Psoriatic Arthritis

Search NIH Clinical Center for Psoriatic Arthritis

Search CenterWatch for Psoriatic Arthritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Psoriatic Arthritis

About this section

Anatomical Context for Psoriatic Arthritis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Psoriatic Arthritis:

32
Skin, Testes, Bone, T cells, Endothelial, Heart, Monocytes, Liver, Eye, Thyroid, Myeloid

Animal Models for Psoriatic Arthritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Psoriatic Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.9ERAP1, NOD2, IL23R, IL23A, IL12B, CDSN

Publications for Psoriatic Arthritis

About this section
Sources:
50PubMed
See all sources

Articles related to Psoriatic Arthritis:

(show top 50)    (show all 847)
idTitleAuthorsYear
1
Ustekinumab for the treatment of psoriatic arthritis. (24410536)
2014
2
Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force. (23749611)
2014
3
Effect of tumour necrosis factor blockers on radiographic progression of psoriatic arthritis: a systematic review and meta-analysis of randomised controlled trials. (23355079)
2014
4
Role of IL-17 in psoriasis and psoriatic arthritis. (22362575)
2013
5
Unmet needs in outcome measures of Psoriatic Arthritis: focus on axial radiographic and nail involvement. (24165456)
2013
6
Psoriatic arthritis mutilans: case series and literature review. (23818727)
2013
7
Besides the HLA loci: SNPs and non-HLA gene products as immunoregulatory factors in the onset of psoriatic arthritis subtypes. (24152856)
2013
8
Mutilating/resorptive arthritis. A study of 24 patients in a series of 360 patients with psoriatic arthritis. (23245639)
2013
9
Early psoriatic arthritis: facing the challenge. (24067311)
2013
10
Health-related quality of life in psoriatic arthritis patients in Spain. (24099960)
2013
11
Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis. (23093722)
2013
12
Is reduction or discontinuation of therapy an acceptable possibility in psoriatic arthritis? (24129140)
2013
13
Classification criteria: peripheral spondyloarthropathy and psoriatic arthritis. (23436006)
2013
14
Group for Research and Assesment of Psoriasis and Psoriatic Arthritis - GRAPPA (2003-2013). (24316891)
2013
15
Soluble biomarkers associated with response to treatment with tumor necrosis factor inhibitors in psoriatic arthritis. (23637322)
2013
16
Prevalence and incidence rates of psoriatic arthritis in central Norway: data from the Nord-Trondelag Health Study (HUNT). (23962458)
2013
17
Nail Assessment in Psoriasis and Psoriatic Arthritis (NAPPA): Development and Validation of a Tool for Assessment of Nail Psoriasis Outcomes. (24117393)
2013
18
Optic neuritis in a psoriatic arthritis patient treated by infliximab. (23289758)
2013
19
Mixture distributions in multi-state modelling: some considerations in a study of psoriatic arthritis. (22833400)
2013
20
The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project). (22798567)
2013
21
Reduced joint counts misclassify patients with oligoarticular psoriatic arthritis and miss significant numbers of patients with active disease. (23529837)
2013
22
Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease. (22562972)
2013
23
Psoriatic arthritis: radiographic joint repair following etanercept therapy. (22210679)
2012
24
Successful treatment with adalimumab in a patient with psoriatic arthritis and generalized pustular psoriasis. (22506677)
2012
25
Prevalence of eye disease in Brazilian patients with psoriatic arthritis. (22473406)
2012
26
Psoriatic arthritis: treatment strategies using anti-inflammatory drugs and classical DMARDs. (22690387)
2012
27
Combination biologic treatment of refractory psoriasis and psoriatic arthritis. (22210681)
2012
28
Axial psoriatic arthritis: an intriguing clinical entity or a subset of an intriguing disease? (22552858)
2012
29
Update on biomarkers in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting. (22298273)
2012
30
Effects of polymorphisms in TRAILR1 and TNFR1A on the response to anti-TNF therapies in patients with rheumatoid and psoriatic arthritis. (22480748)
2012
31
What have genome-wide studies told us about psoriatic arthritis? (22532288)
2012
32
Etanercept and adalimumab treatment patterns in psoriatic arthritis patients enrolled in a commercial health plan. (22903239)
2012
33
Etanercept therapy for psoriatic arthritis in the presence of recurrent non-Hodgkin lymphoma. (22955480)
2012
34
A multicentre study on high-frequency ultrasound evaluation of the skin and joints in patients with psoriatic arthritis treated with infliximab. (23020866)
2012
35
Future trends in research in psoriatic arthritis. (22751608)
2012
36
Osteoporosis in psoriatic arthritis: is there any? (22127468)
2011
37
Juvenile psoriatic arthritis and comorbidities: report of a case associated with enthesitis and celiac disease. (20482570)
2010
38
Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase 3. (20237127)
2010
39
Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. (19942450)
2010
40
Deletion of LCE3C and LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients. (19439430)
2010
41
Psoriatic arthritis: pharmacoeconomic considerations. (19691929)
2009
42
Juvenile psoriatic arthritis: bathwater or baby? (19738207)
2009
43
Comparison of patients with juvenile psoriatic arthritis and nonpsoriatic juvenile idiopathic arthritis: how different are they? (19648305)
2009
44
Male restricted genetic association of variant R620W in PTPN22 with psoriatic arthritis. (16456530)
2006
45
Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort. (15539411)
2005
46
Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective. (15251081)
2004
47
Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population. (15140210)
2004
48
Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. (12746914)
2003
49
Impaired expression of erythrocyte glycosyl-phosphatidylinositol-anchored membrane CD59 in patients with psoriatic arthritis. Relation to terminal complement pathway activation. (12747280)
2003
50
Inflammatory infiltrate and interleukin-8 expression in the synovium of psoriatic arthritis--an immunohistochemical and mRNA analysis. (9440147)
1997

Genetic Variations for Psoriatic Arthritis

About this section

Expression for genes affiliated with Psoriatic Arthritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Psoriatic Arthritis

Search GEO for disease gene expression data for Psoriatic Arthritis.

Pathways for genes affiliated with Psoriatic Arthritis

About this section
Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
See all sources

Pathways related to Psoriatic Arthritis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7ERAP1, NOD2, KIR2DS1, KIR2DS2, KIR2DL1
2
Hide members
10.7TNFRSF12A, LTA, IL12B, IL23A, IL23R
3
Hide members
10.7TNFRSF12A, LTA, IL12B, IL23A, IL23R
4
Hide members
10.7TNFRSF12A, LTA, IL12B, IL23A, IL23R
5
Hide members
10.7NOD2, IL23R, IL23A, IL12B
6
Development PDGF signaling via STATs and NF-kB
Hide members
10.7TNIP1, IL12B, IL23A, IL23R
7
Hide members
10.6IL12B, LTA, TNFRSF12A
8
Cytokine production by Th17 cells in CF (Mouse model)
10.6IL23R, IL23A, IL12B
9
Hide members
10.6IL12B, IL23A, IL23R
10
Hide members
10.6KIR2DS1, KIR2DS2, KIR2DL1
11
Hide members
10.6KIR2DL1, KIR2DS2, KIR2DS1

Compounds for genes affiliated with Psoriatic Arthritis

About this section
Sources:
44Novoseek
See all sources

Compounds related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il 104410.6NOD2, IL12B, LTA

GO Terms for genes affiliated with Psoriatic Arthritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-23 complexGO:07074310.6IL23A, IL12B

Biological processes related to Psoriatic Arthritis according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274011.1NOD2, IL23R, IL23A, IL12B
2positive regulation of interleukin-12 productionGO:03273511.1IL12B, IL23A, IL23R, NOD2
3positive regulation of interferon-gamma productionGO:03272911.1LTA, IL12B, IL23A, IL23R
4regulation of tyrosine phosphorylation of Stat1 proteinGO:04251011.0IL23R, IL23A, IL12B
5positive regulation of inflammatory responseGO:05072911.0S100A12, TNIP1, IL12B, IL23A
6positive regulation of T-helper 17 cell lineage commitmentGO:200033011.0IL12B, IL23A, IL23R
7positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252011.0IL12B, IL23A, IL23R
8positive regulation of NK T cell activationGO:05113511.0IL12B, IL23A, IL23R
9positive regulation of memory T cell differentiationGO:04338211.0IL12B, IL23A, IL23R
10positive regulation of T-helper 17 type immune responseGO:200031811.0IL12B, IL23A, IL23R
11positive regulation of natural killer cell proliferationGO:03281911.0IL12B, IL23A, IL23R
12positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272511.0IL12B, IL23R, IL23A
13positive regulation of activation of JAK2 kinase activityGO:01053511.0IL23R, IL23A, IL12B
14negative regulation of interleukin-10 productionGO:03269311.0IL23R, IL23A, IL12B
15negative regulation of growth of symbiont in hostGO:04413011.0LTA, IL12B, NOD2
16positive regulation of T-helper 1 type immune responseGO:00282711.0IL23R, IL23A, IL12B
17positive regulation of osteoclast differentiationGO:04567211.0IL12B, IL23A, IL23R
18positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.0IL12B, IL23A, IL23R
19positive regulation of interleukin-10 productionGO:03273311.0IL12B, IL23A, NOD2
20positive regulation of defense response to virus by hostGO:00223010.9IL12B, IL23A, IL23R
21positive regulation of activated T cell proliferationGO:04210410.9IL12B, IL23A, IL23R
22defense response to Gram-negative bacteriumGO:05082910.9IL12B, IL23A, IL23R
23positive regulation of T cell mediated cytotoxicityGO:00191610.9IL12B, IL23A, IL23R
24positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.9IL23R, IL23A, IL12B
25positive regulation of tumor necrosis factor productionGO:03276010.9IL12B, IL23A, NOD2
26positive regulation of T cell proliferationGO:04210210.9IL23R, IL23A, IL12B
27positive regulation of NK T cell proliferationGO:05114210.8IL23A, IL12B
28positive regulation of tissue remodelingGO:03410510.8IL12B, IL23A
29positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8LTA, NOD2
30negative regulation of inflammatory response to antigenic stimulusGO:00286210.8NOD2, IL12B
31inflammatory responseGO:00695410.7IL23R, IL23A, TNIP1, S100A12
32regulation of immune responseGO:05077610.7KIR2DL1, KIR2DS2, KIR2DS1
33positive regulation of natural killer cell activationGO:03281610.7IL23A, IL12B
34innate immune responseGO:04508710.7S100A12, IL23A, KIR2DS2, KIR2DS1, NOD2
35positive regulation of NF-kappaB import into nucleusGO:04234610.6IL23A, IL12B
36response to lipopolysaccharideGO:03249610.5NOD2, IL23R, LTA
37immune responseGO:00695510.4IGHA1, KIR2DL1, KIR2DS2, KIR2DS1

Molecular functions related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 receptor bindingGO:00514310.6IL23R, IL12B
2interleukin-23 receptor bindingGO:04551910.3IL23A, IL12B

Products for genes affiliated with Psoriatic Arthritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Psoriatic Arthritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet