MCID: PSR001
MIFTS: 56

Psoriatic Arthritis malady

Skin category

Summaries for Psoriatic Arthritis

Sources:
8Disease Ontology, 34MedlinePlus, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get them on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people with psoriasis have psoriatic arthritis. it causes pain, stiffness, and swelling of the joints. it is often mild, but can sometimes be serious and affect many joints. the joint and skin problems don't always happen at the same time. your doctor will do a physical exam and imaging tests to diagnose psoriatic arthritis. there is no cure, but medicines can help control inflammation and pain. in rare cases, you might need surgery to repair or replace damaged joints.

MalaCards: Psoriatic Arthritis, also known as psoriatic arthritis, susceptibility to, is related to arthritis and spondylitis. An important gene associated with Psoriatic Arthritis is LTA (lymphotoxin alpha), and among its related pathways are Immune System and PAK Pathway. The drugs auranofin and aurothioglucose and the compound il 10 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and whole blood, and related mouse phenotype immune system.

Disease Ontology:8 A syndrome that occurs in humans with psoriasis who also experience symptoms similar to arthritis.

Genetics Home Reference:21 Psoriatic arthritis is a condition involving joint inflammation (arthritis) that usually occurs in combination with a skin disorder called psoriasis. Psoriasis is a chronic inflammatory condition characterized by patches of red, irritated skin that are often covered by flaky white scales. People with psoriasis may also have changes in their fingernails and toenails, such as nails that become pitted or ridged, crumble, or separate from the nail beds.

Wikipedia:64 Psoriatic arthritis (also arthritis psoriatica, arthropathic psoriasis or psoriatic arthropathy) is a... more...

Description from OMIM:47 607507

Aliases & Classifications for Psoriatic Arthritis

Sources:
8Disease Ontology, 21Genetics Home Reference, 47OMIM, 10DISEASES, 34MedlinePlus, 9diseasecard, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

psoriatic arthritis 8 21 47 10 34
psoriatic arthritis, susceptibility to 9
arthropathic psoriasis 8
psoriatic arthropathy 21
arthritis, psoriatic 61
arthritis psoriatica 8
arthritis psoriatic 45


External Ids:

Disease Ontology8 DOID:9008
ICD9CM27 696.0
NCIt40 C61277
MeSH35 D015535
ICD1025 L40.5

Related Diseases for Psoriatic Arthritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Psoriatic Arthritis family:

juvenile psoriatic arthritis

Diseases related to Psoriatic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.3NOD2, IL23A, LTA, S100A12
2spondylitis31.2NOD2
3ankylosing spondylitis31.2ERAP1, IL23R
4hepatitis c30.4IL12B
5systemic lupus erythematosus30.3NOD2, IL23A, IL12B, LTA
6uveitis30.1NOD2, LTA
7atopic dermatitis30.1LTA, CDSN, IL12B, NOD2
8crohn's disease30.1NOD2, IL23R
9familial mediterranean fever30.1NOD2
10tuberculosis30.1IL12B, IL23A, NOD2
11juvenile psoriatic arthritis10.8
12osteoarthritis10.6
13synovitis10.5
14reactive arthritis10.5
15newcastle disease10.4
16atherosclerosis10.4
17osteoporosis10.4
18psoriatic juvenile idiopathic arthritis10.4
19sapho syndrome10.4
20juvenile rheumatoid arthritis10.4
21spondyloarthropathy10.4
22generalized pustular psoriasis10.4
23fibromyalgia10.4
24rheumatic disease10.4
25ankylosis10.3
26hyperuricemia10.3
27hepatitis a10.3
28acne10.3
29relapsing polychondritis10.2
30reflex sympathetic dystrophy10.2
31hepatitis e10.2
32angioedema10.2
33arthropathy10.2
34vasculitis10.2
35collagenous colitis10.2
36enthesitis-related juvenile idiopathic arthritis10.2
37mycobacterium marinum10.2
38hepatitis c virus10.2
39oligoarticular juvenile arthritis10.2
40enthesitis-related arthritis10.2
41eosinophilic fasciitis10.1
42bone fracture10.1
43gout10.1
44bullous pemphigoid10.1
45renal osteodystrophy10.1
46discitis10.1
47membranous glomerulonephritis10.1
48diffuse idiopathic skeletal hyperostosis10.1
49acute pancreatitis10.1
50acrodermatitis10.1

Graphical network of the top 20 diseases related to Psoriatic Arthritis:



Diseases related to psoriatic arthritis

Clinical Features for Psoriatic Arthritis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

607507

Drugs & Therapeutics for Psoriatic Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Psoriatic Arthritis

Drug clinical trials:

Search ClinicalTrials for Psoriatic Arthritis

Search NIH Clinical Center for Psoriatic Arthritis

Search CenterWatch for Psoriatic Arthritis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Psoriatic Arthritis

Anatomical Context for Psoriatic Arthritis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Psoriatic Arthritis:

33
Skin, Liver, Whole blood, Heart, Thyroid, Myeloid, Monocytes, T cells, B cells, Endothelial

Animal Models for Psoriatic Arthritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Psoriatic Arthritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.9ERAP1, NOD2, IL23R, IL23A, IL12B, CDSN

Publications for Psoriatic Arthritis

Sources:
51PubMed
See all sources

Articles related to Psoriatic Arthritis:

(show top 50)    (show all 848)
idTitleAuthorsYear
1
Ustekinumab for the treatment of psoriatic arthritis. (24410536)
2014
2
Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force. (23749611)
2014
3
Role of IL-17 in psoriasis and psoriatic arthritis. (22362575)
2013
4
Unmet needs in outcome measures of Psoriatic Arthritis: focus on axial radiographic and nail involvement. (24165456)
2013
5
Psoriatic arthritis mutilans: case series and literature review. (23818727)
2013
6
Besides the HLA loci: SNPs and non-HLA gene products as immunoregulatory factors in the onset of psoriatic arthritis subtypes. (24152856)
2013
7
Mutilating/resorptive arthritis. A study of 24 patients in a series of 360 patients with psoriatic arthritis. (23245639)
2013
8
Early psoriatic arthritis: facing the challenge. (24067311)
2013
9
Health-related quality of life in psoriatic arthritis patients in Spain. (24099960)
2013
10
Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis. (23093722)
2013
11
Is reduction or discontinuation of therapy an acceptable possibility in psoriatic arthritis? (24129140)
2013
12
Classification criteria: peripheral spondyloarthropathy and psoriatic arthritis. (23436006)
2013
13
Group for Research and Assesment of Psoriasis and Psoriatic Arthritis - GRAPPA (2003-2013). (24316891)
2013
14
Serum complement C3 correlates with insulin resistance in never treated psoriatic arthritis patients. (24005838)
2013
15
Treatment patterns and health care costs for patients with psoriatic arthritis on biologic therapy: a retrospective cohort study. (23954091)
2013
16
Long-term work disability in patients with psoriatic arthritis treated with anti-tumour necrosis factor: a population-based regional Swedish cohort study. (23148309)
2013
17
Negative and positive life experiences in patients with psoriatic arthritis. (23179260)
2013
18
Recommendations for the Coordinated Management of Psoriatic Arthritis by Rheumatologists and Dermatologists: A Delphi Study. (24007810)
2013
19
The role of p38 MAPK in the aetiopathogenesis of psoriasis and psoriatic arthritis. (24151518)
2013
20
Effect of certolizumab pegol on multiple facets of psoriatic arthritis as reported by patients: 24-week patient-reported outcome results of the RAPID-PsA study. (24339179)
2013
21
Enthesitis in psoriatic arthritis. (23731532)
2013
22
Psoriatic arthritis: radiographic joint repair following etanercept therapy. (22210679)
2012
23
Successful treatment with adalimumab in a patient with psoriatic arthritis and generalized pustular psoriasis. (22506677)
2012
24
Prevalence of eye disease in Brazilian patients with psoriatic arthritis. (22473406)
2012
25
Psoriatic arthritis: treatment strategies using anti-inflammatory drugs and classical DMARDs. (22690387)
2012
26
Combination biologic treatment of refractory psoriasis and psoriatic arthritis. (22210681)
2012
27
Axial psoriatic arthritis: an intriguing clinical entity or a subset of an intriguing disease? (22552858)
2012
28
Update on biomarkers in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting. (22298273)
2012
29
Patients with psoriatic arthritis have worse quality of life than those with psoriasis alone. (22157469)
2012
30
Performance of hands and feet radiographs in differentiation of psoriatic arthritis from rheumatoid arthritis. (23083036)
2012
31
MRI and ultrasonography for diagnosis and monitoring of psoriatic arthritis. (23273793)
2012
32
Cardiovascular mortality in psoriasis and psoriatic arthritis: epidemiology, pathomechanisms, therapeutic implications, and perspectives. (22562431)
2012
33
Increase in ventricular-arterial stiffness in patients with psoriatic arthritis. (22923754)
2012
34
Abstracts of the 3rd World Psoriasis & Psoriatic Arthritis Conference 2012: "Psoriasis-a global health challenge" : Stockholm, Sweden, June 27-July 1, 2012. (24318398)
2012
35
Distinguishing inflammatory from noninflammatory arthritis, enthesitis, and dactylitis in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting. (22298269)
2012
36
Osteoporosis in psoriatic arthritis: is there any? (22127468)
2011
37
Juvenile psoriatic arthritis and comorbidities: report of a case associated with enthesitis and celiac disease. (20482570)
2010
38
Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase 3. (20237127)
2010
39
Psoriatic arthritis: pharmacoeconomic considerations. (19691929)
2009
40
Juvenile psoriatic arthritis: bathwater or baby? (19738207)
2009
41
HLA-Cw*06 class I region rather than MICA is associated with psoriatic arthritis in Czech population. (19184033)
2009
42
Treatment of psoriatic arthritis and rheumatoid arthritis with disease modifying drugs -- comparison of drugs and adverse reactions. (18203324)
2008
43
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. (18369459)
2008
44
Male restricted genetic association of variant R620W in PTPN22 with psoriatic arthritis. (16456530)
2006
45
Case of acrodermatitis continua accompanied by psoriatic arthritis. (17073995)
2006
46
The role of biological agents in the treatment of psoriatic arthritis, literature review]. (17120686)
2006
47
Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort. (15539411)
2005
48
Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective. (15251081)
2004
49
SAPHO syndrome or psoriatic arthritis? A familial case study. (10371287)
1999
50
Blood prolactin under the effect of protirelin in spondylarthropathies. Treatment trial of 4 cases of reactive arthritis and 2 cases of psoriatic arthritis with bromocriptine]. (8763085)
1996

Genetic Variations for Psoriatic Arthritis

Expression for genes affiliated with Psoriatic Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Psoriatic Arthritis

Search GEO for disease gene expression data for Psoriatic Arthritis.

Pathways for genes affiliated with Psoriatic Arthritis

Sources:
54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Psoriatic Arthritis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7ERAP1, NOD2, KIR2DS1, KIR2DS2, KIR2DL1
2
Hide members
10.7LTA, IL12B, IL23A, IL23R, TNFRSF12A
3
Hide members
10.7IL12B, LTA, TNFRSF12A, IL23R, IL23A
4
Hide members
10.7IL23A, IL23R, TNFRSF12A, LTA, IL12B
5
Hide members
10.7IL12B, IL23A, NOD2, IL23R
6
Development PDGF signaling via STATs and NF-kB
Hide members
10.7IL23R, IL23A, IL12B, TNIP1
7
Hide members
10.6IL12B, LTA, TNFRSF12A
8
Hide members
10.6IL23R, IL23A, IL12B
9
Cytokine production by Th17 cells in CF (Mouse model)
10.6IL12B, IL23R, IL23A
10
Hide members
10.6KIR2DS1, KIR2DS2, KIR2DL1
11
Hide members
10.6KIR2DS2, KIR2DL1, KIR2DS1

Compounds for genes affiliated with Psoriatic Arthritis

Sources:
45Novoseek
See all sources

Compounds related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il 104510.6NOD2, IL12B, LTA

GO Terms for genes affiliated with Psoriatic Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-23 complexGO:07074310.6IL23A, IL12B

Biological processes related to Psoriatic Arthritis according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274011.1IL12B, IL23A, NOD2, IL23R
2positive regulation of interleukin-12 productionGO:03273511.1IL12B, IL23A, IL23R, NOD2
3positive regulation of interferon-gamma productionGO:03272911.1LTA, IL12B, IL23A, IL23R
4regulation of tyrosine phosphorylation of Stat1 proteinGO:04251011.0IL12B, IL23A, IL23R
5positive regulation of inflammatory responseGO:05072911.0S100A12, IL23A, TNIP1, IL12B
6positive regulation of T-helper 17 cell lineage commitmentGO:200033011.0IL23R, IL12B, IL23A
7positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252011.0IL23R, IL12B, IL23A
8positive regulation of NK T cell activationGO:05113511.0IL23R, IL23A, IL12B
9positive regulation of memory T cell differentiationGO:04338211.0IL23R, IL23A, IL12B
10positive regulation of natural killer cell proliferationGO:03281911.0IL12B, IL23R, IL23A
11positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272511.0IL12B, IL23A, IL23R
12positive regulation of T-helper 17 type immune responseGO:200031811.0IL23R, IL23A, IL12B
13positive regulation of activation of JAK2 kinase activityGO:01053511.0IL23R, IL12B, IL23A
14negative regulation of interleukin-10 productionGO:03269311.0IL23A, IL12B, IL23R
15negative regulation of growth of symbiont in hostGO:04413011.0IL12B, LTA, NOD2
16positive regulation of T-helper 1 type immune responseGO:00282711.0IL12B, IL23A, IL23R
17positive regulation of defense response to virus by hostGO:00223011.0IL23A, IL12B, IL23R
18positive regulation of interleukin-10 productionGO:03273311.0IL23A, IL12B, NOD2
19positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.0IL23A, IL12B, IL23R
20positive regulation of osteoclast differentiationGO:04567210.9IL12B, IL23A, IL23R
21positive regulation of activated T cell proliferationGO:04210410.9IL23A, IL12B, IL23R
22defense response to Gram-negative bacteriumGO:05082910.9IL23R, IL12B, IL23A
23positive regulation of T cell mediated cytotoxicityGO:00191610.9IL12B, IL23A, IL23R
24positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.9IL12B, IL23R, IL23A
25positive regulation of tumor necrosis factor productionGO:03276010.9NOD2, IL23A, IL12B
26positive regulation of T cell proliferationGO:04210210.9IL23R, IL23A, IL12B
27positive regulation of NK T cell proliferationGO:05114210.8IL23A, IL12B
28positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8LTA, NOD2
29positive regulation of tissue remodelingGO:03410510.8IL12B, IL23A
30positive regulation of natural killer cell activationGO:03281610.8IL23A, IL12B
31inflammatory responseGO:00695410.7TNIP1, S100A12, IL23R, IL23A
32regulation of immune responseGO:05077610.7KIR2DS2, KIR2DS1, KIR2DL1
33negative regulation of inflammatory response to antigenic stimulusGO:00286210.7IL12B, NOD2
34innate immune responseGO:04508710.7S100A12, KIR2DS1, KIR2DS2, IL23A, NOD2
35positive regulation of NF-kappaB import into nucleusGO:04234610.6IL23A, IL12B
36response to lipopolysaccharideGO:03249610.5LTA, IL23R, NOD2
37immune responseGO:00695510.4KIR2DS1, KIR2DS2, KIR2DL1, IGHA1

Molecular functions related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 receptor bindingGO:00514310.6IL23R, IL12B
2interleukin-23 receptor bindingGO:04551910.3IL23A, IL12B

Products for genes affiliated with Psoriatic Arthritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Psoriatic Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet