MCID: PSR001
MIFTS: 57

Psoriatic Arthritis malady

Skin diseases category

Summaries for Psoriatic Arthritis

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8Disease Ontology, 21Genetics Home Reference, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. you usually get them on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. some people with psoriasis have psoriatic arthritis. it causes pain, stiffness, and swelling of the joints. it is often mild, but can sometimes be serious and affect many joints. the joint and skin problems don't always happen at the same time. your doctor will do a physical exam and imaging tests to diagnose psoriatic arthritis. there is no cure, but medicines can help control inflammation and pain. in rare cases, you might need surgery to repair or replace damaged joints.

MalaCards: Psoriatic Arthritis, also known as arthropathic psoriasis, is related to arthritis and psoriasis. An important gene associated with Psoriatic Arthritis is LTA (lymphotoxin alpha), and among its related pathways are Immune System and PAK Pathway. The drugs auranofin and aurothioglucose and the compound il 10 have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related mouse phenotype immune system.

Disease Ontology:8 A syndrome that occurs in humans with psoriasis who also experience symptoms similar to arthritis.

Genetics Home Reference:21 Psoriatic arthritis is a condition involving joint inflammation (arthritis) that usually occurs in combination with a skin disorder called psoriasis. Psoriasis is a chronic inflammatory condition characterized by patches of red, irritated skin that are often covered by flaky white scales. People with psoriasis may also have changes in their fingernails and toenails, such as nails that become pitted or ridged, crumble, or separate from the nail beds.

Wikipedia:63 Psoriatic arthritis (also arthritis psoriatica, arthropathic psoriasis or psoriatic arthropathy) is a... more...

Description from OMIM:46 607507

Aliases & Classifications for Psoriatic Arthritis

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Sources:
8Disease Ontology, 21Genetics Home Reference, 46OMIM, 10DISEASES, 33MedlinePlus, 9diseasecard, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

psoriatic arthritis 8 21 46 10 33
arthropathic psoriasis 8 21
psoriatic arthritis, susceptibility to 9
psoriatic arthropathy 21
arthritis, psoriatic 60
arthritis psoriatica 8
arthritis psoriatic 44


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Disease Ontology8 DOID:9008
ICD9CM27 696.0
NCIt39 C61277
MeSH34 D015535
ICD1025 L40.5

Related Diseases for Psoriatic Arthritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Psoriatic Arthritis family:

Juvenile Psoriatic Arthritis

Diseases related to Psoriatic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.2NOD2, IL23A, LTA, S100A12
2psoriasis31.7LCE3C, LCE3B, S100A12, TNIP1, LTA, CDSN
3rheumatoid arthritis31.4S100A12, TNFRSF12A, LTA, IL12B, IL23A, IL23R
4spondylitis31.2NOD2
5ankylosing spondylitis31.2ERAP1, IL23R
6hepatitis30.5LTA
7crohn's disease30.5NOD2, IL23R
8dermatitis30.2NOD2
9systemic lupus erythematosus30.2NOD2, IL23A, IL12B, LTA
10uveitis30.0NOD2, LTA
11atopic dermatitis30.0LTA, CDSN, IL12B, NOD2
12familial mediterranean fever30.0NOD2
13tuberculosis30.0IL12B, IL23A, NOD2
14hepatitis c30.0IL12B
15nail disease10.6
16reactive arthritis10.6
17osteoarthritis10.5
18synovitis10.5
19obesity10.5
20spondyloarthropathy10.5
21newcastle disease10.4
22atherosclerosis10.4
23osteoporosis10.4
24sapho syndrome10.3
25juvenile rheumatoid arthritis10.3
26enthesopathy10.3
27hyperostosis10.3
28skin disease10.3
29ankylosis10.3
30hyperuricemia10.3
31hepatitis a10.3
32acne10.3
33glomerulonephritis10.3
34juvenile psoriatic arthritis10.3
35relapsing polychondritis10.2
36reflex sympathetic dystrophy10.2
37angioedema10.2
38arthropathy10.2
39iridocyclitis10.2
40leishmaniasis10.2
41lupus erythematosus10.2
42melanoma10.2
43nervous system disease10.2
44pancreatitis10.2
45vasculitis10.2
46fasciitis10.1
47bone fracture10.0
48gout10.0
49bullous pemphigoid10.0
50renal osteodystrophy10.0

Graphical network of the top 20 diseases related to Psoriatic Arthritis:



Diseases related to psoriatic arthritis

Clinical Features for Psoriatic Arthritis

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Sources:
46OMIM
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Clinical features from OMIM:

607507

Drugs & Therapeutics for Psoriatic Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Psoriatic Arthritis

Drug clinical trials:

Search ClinicalTrials for Psoriatic Arthritis

Search NIH Clinical Center for Psoriatic Arthritis

Search CenterWatch for Psoriatic Arthritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Psoriatic Arthritis

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Anatomical Context for Psoriatic Arthritis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Psoriatic Arthritis:

32
Skin, Testes, Bone, T cells, Endothelial, Heart, Liver, Monocytes, Thyroid, Myeloid, Eye

Animal Models for Psoriatic Arthritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Psoriatic Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.9ERAP1, NOD2, IL23R, IL23A, IL12B, CDSN

Publications for Psoriatic Arthritis

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50PubMed
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Articles related to Psoriatic Arthritis:

(show top 50)    (show all 847)
idTitleAuthorsYear
1
Effect of different imputation approaches on the evaluation of radiographic progression in patients with psoriatic arthritis: results of the RAPID-PsA 24-week phase III double-blind randomised placebo-controlled study of certolizumab pegol. (23942869)
2014
2
Melkersson-Rosenthal syndrome in a patient with psoriatic arthritis receiving etanercept. (23527726)
2013
3
The TICOPA protocol (TIght COntrol of Psoriatic Arthritis): a randomised controlled trial to compare intensive management versus standard care in early psoriatic arthritis. (23517506)
2013
4
Clinical response, drug survival, and predictors thereof among 548 patients with psoriatic arthritis who switched tumor necrosis factor I+ inhibitor therapy: results from the Danish Nationwide DANBIO Registry. (23460467)
2013
5
Tumour necrosis factor I+ blockers are more effective than methotrexate in the inhibition of radiographic joint damage progression among patients with psoriatic arthritis. (23619157)
2013
6
Erosive discovertebral lesion (Andersson lesion) as the first sign of disease in axial psoriatic arthritis. (23311864)
2013
7
The Beneficial Effect of Total Glucosides of Paeony on Psoriatic Arthritis Links to Circulating Tregs and Th1 Cell Function. (23610010)
2013
8
From inhibition of radiographic progression to maintaining structural integrity: a methodological framework for radiographic progression in rheumatoid arthritis and psoriatic arthritis clinical trials. (23619156)
2013
9
Psoriasis beyond the skin: an expert group consensus on the management of psoriatic arthritis and common co-morbidities in patients with moderate-to-severe psoriasis. (24372845)
2013
10
Differential expression of proteins with heparin affinity in patients with rheumatoid and psoriatic arthritis: a preliminary study. (23739182)
2013
11
Can traditional disease-modifying anti-rheumatic drugs be withdrawn or tapered in psoriatic arthritis? (24129139)
2013
12
No enthesis should be overlooked when psoriatic arthritis is suspected: enthesitis of the extensor digitorum tendons. (23457399)
2013
13
Side effects of TNF-I+ blockers in patients with psoriatic arthritis: evidences from literature studies. (23588881)
2013
14
Osteoporosis in psoriatic arthritis: an assessment of densitometry and fragility fractures. (23846386)
2013
15
Psoriatic arthritis that responded dramatically when infliximab was switched to adalimumab. (24371401)
2013
16
Successful use of tocilizumab in a patient with psoriatic arthritis. (23424264)
2013
17
Is there sub-clinical synovitis in early psoriatic arthritis? A clinical comparison with grey scale and power Doppler ultrasound. (24022986)
2013
18
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. (22383354)
2012
19
New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis. (23116200)
2012
20
Meta-analysis of NOD2/CARD15 polymorphisms with psoriasis and psoriatic arthritis. (21448648)
2012
21
Determination of lymphotoxin-alpha levels in patients with psoriatic arthritis undergoing etanercept treatment. (22480318)
2012
22
Construct validity of the modified numeric rating scale of patient global assessment in psoriatic arthritis. (22422489)
2012
23
Care and support of patients with psoriatic arthritis. (23061128)
2012
24
IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients. (21613309)
2011
25
Toll-like receptor (TLR) 2 is upregulated on peripheral blood monocytes of patients with psoriatic arthritis: a role for a gram-positive inflammatory trigger? (22133017)
2011
26
Incidence and prevalence of psoriatic arthritis, ankylosing spondylitis, and reactive arthritis in the first descriptive population-based study in the Czech Republic. (20476864)
2010
27
Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking. (19554022)
2009
28
Arthralgia as an adverse event to infliximab: a reactive arthritis or triggering of psoriatic arthritis? Successful management by switching to etanercept. (19207660)
2009
29
The effectiveness of a traditional therapeutical approach in early psoriatic arthritis: results of a pilot randomised 6-month trial with methotrexate. (18030515)
2008
30
Risks and benefits of tumor necrosis factor-alpha inhibitors in the management of psoriatic arthritis: systematic review and metaanalysis of randomized controlled trials. (18381787)
2008
31
Genetics of psoriasis and psoriatic arthritis. (17828355)
2007
32
Prediction of major clinical response (ACR50) to infliximab in psoriatic arthritis refractory to methotrexate. (17179176)
2007
33
Loss-of-function variants of the filaggrin gene are not major susceptibility factors for psoriasis vulgaris or psoriatic arthritis in German patients. (17255953)
2007
34
The comparative effectiveness of anti-TNF therapy and methotrexate in patients with psoriatic arthritis: 6 month results from a longitudinal, observational, multicentre study. (17213251)
2007
35
Resolution of treatment-related arthralgias and serologic findings with a switch of TNF antagonist therapies in a patient with psoriatic arthritis. (17921804)
2007
36
Anti-TNF-alpha agents in the treatment of psoriatic arthritis. (16436036)
2006
37
Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study. (16507123)
2006
38
Short-term infliximab therapy improves symptoms of psoriatic arthritis and decreases concentrations of cartilage oligomeric matrix protein. (16635048)
2006
39
Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. (15476228)
2004
40
Role of novel biological therapies in psoriatic arthritis: effects on joints and skin. (12749755)
2003
41
Changing paradigms in dermatology: tumor necrosis factor alpha (TNF-alpha) blockade in psoriasis and psoriatic arthritis. (14678719)
2003
42
Increased perivascular synovial membrane expression of myeloid-related proteins in psoriatic arthritis. (12794836)
2003
43
Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis. (12421111)
2002
44
Ankylosing spondylitis, psoriatic arthritis, and reactive arthritis show increased bone resorption, but differ with regard to bone formation. (12136902)
2002
45
Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis. (12011375)
2002
46
Soluble interleukin-2 receptor and interleukin-6 levels: evaluation during cyclosporin A and methotrexate treatment in psoriatic arthritis. (9586691)
1998
47
T cell derived cytokines in psoriatic arthritis synovial fluids. (9924213)
1998
48
Interleukin-2 is found in the synovium of psoriatic arthritis and spondyloarthritis, not in rheumatoid arthritis. (8792801)
1996
49
Interleukin-1 beta, plasminogen activator and inhibitor of plasminogen activator in synovial fluid of rheumatoid arthritis, psoriatic arthritis and osteoarthritis. (8079828)
1994
50
Atlantoaxial subluxation in a patient with psoriatic arthritis. (2803333)
1989

Genetic Variations for Psoriatic Arthritis

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Expression for genes affiliated with Psoriatic Arthritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psoriatic Arthritis

Search GEO for disease gene expression data for Psoriatic Arthritis.

Pathways for genes affiliated with Psoriatic Arthritis

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
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Pathways related to Psoriatic Arthritis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.7ERAP1, NOD2, KIR2DS1, KIR2DS2, KIR2DL1
2
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10.7TNFRSF12A, LTA, IL12B, IL23A, IL23R
3
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10.7TNFRSF12A, LTA, IL12B, IL23A, IL23R
4
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10.7TNFRSF12A, LTA, IL12B, IL23A, IL23R
5
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10.7NOD2, IL23R, IL23A, IL12B
6
Development PDGF signaling via STATs and NF-kB
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10.7TNIP1, IL12B, IL23A, IL23R
7
Hide members
10.6IL12B, LTA, TNFRSF12A
8
Cytokine production by Th17 cells in CF (Mouse model)
10.6IL23R, IL23A, IL12B
9
Hide members
10.6IL12B, IL23A, IL23R
10
Hide members
10.6KIR2DS1, KIR2DS2, KIR2DL1
11
Hide members
10.6KIR2DL1, KIR2DS2, KIR2DS1

Compounds for genes affiliated with Psoriatic Arthritis

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44Novoseek
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Compounds related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il 104410.6NOD2, IL12B, LTA

GO Terms for genes affiliated with Psoriatic Arthritis

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16Gene Ontology
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Cellular components related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-23 complexGO:07074310.6IL23A, IL12B

Biological processes related to Psoriatic Arthritis according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274011.1NOD2, IL23R, IL23A, IL12B
2positive regulation of interleukin-12 productionGO:03273511.1IL12B, IL23A, IL23R, NOD2
3positive regulation of interferon-gamma productionGO:03272911.1LTA, IL12B, IL23A, IL23R
4regulation of tyrosine phosphorylation of Stat1 proteinGO:04251011.0IL23R, IL23A, IL12B
5positive regulation of inflammatory responseGO:05072911.0S100A12, TNIP1, IL12B, IL23A
6positive regulation of T-helper 17 cell lineage commitmentGO:200033011.0IL12B, IL23A, IL23R
7positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252011.0IL12B, IL23A, IL23R
8positive regulation of NK T cell activationGO:05113511.0IL12B, IL23A, IL23R
9positive regulation of memory T cell differentiationGO:04338211.0IL12B, IL23A, IL23R
10positive regulation of T-helper 17 type immune responseGO:200031811.0IL12B, IL23A, IL23R
11positive regulation of natural killer cell proliferationGO:03281911.0IL12B, IL23A, IL23R
12positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272511.0IL12B, IL23R, IL23A
13positive regulation of activation of JAK2 kinase activityGO:01053511.0IL23R, IL23A, IL12B
14negative regulation of interleukin-10 productionGO:03269311.0IL23R, IL23A, IL12B
15negative regulation of growth of symbiont in hostGO:04413011.0LTA, IL12B, NOD2
16positive regulation of T-helper 1 type immune responseGO:00282711.0IL23R, IL23A, IL12B
17positive regulation of osteoclast differentiationGO:04567211.0IL12B, IL23A, IL23R
18positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.0IL12B, IL23A, IL23R
19positive regulation of interleukin-10 productionGO:03273311.0IL12B, IL23A, NOD2
20positive regulation of defense response to virus by hostGO:00223010.9IL12B, IL23A, IL23R
21positive regulation of activated T cell proliferationGO:04210410.9IL12B, IL23A, IL23R
22defense response to Gram-negative bacteriumGO:05082910.9IL12B, IL23A, IL23R
23positive regulation of T cell mediated cytotoxicityGO:00191610.9IL12B, IL23A, IL23R
24positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.9IL23R, IL23A, IL12B
25positive regulation of tumor necrosis factor productionGO:03276010.9IL12B, IL23A, NOD2
26positive regulation of T cell proliferationGO:04210210.9IL23R, IL23A, IL12B
27positive regulation of NK T cell proliferationGO:05114210.8IL23A, IL12B
28positive regulation of tissue remodelingGO:03410510.8IL12B, IL23A
29positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8LTA, NOD2
30negative regulation of inflammatory response to antigenic stimulusGO:00286210.8NOD2, IL12B
31inflammatory responseGO:00695410.7IL23R, IL23A, TNIP1, S100A12
32regulation of immune responseGO:05077610.7KIR2DL1, KIR2DS2, KIR2DS1
33positive regulation of natural killer cell activationGO:03281610.7IL23A, IL12B
34innate immune responseGO:04508710.7S100A12, IL23A, KIR2DS2, KIR2DS1, NOD2
35positive regulation of NF-kappaB import into nucleusGO:04234610.6IL23A, IL12B
36response to lipopolysaccharideGO:03249610.5NOD2, IL23R, LTA
37immune responseGO:00695510.4IGHA1, KIR2DL1, KIR2DS2, KIR2DS1

Molecular functions related to Psoriatic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 receptor bindingGO:00514310.6IL23R, IL12B
2interleukin-23 receptor bindingGO:04551910.3IL23A, IL12B

Products for genes affiliated with Psoriatic Arthritis

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Sources for Psoriatic Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet