MCID: PSR016
MIFTS: 32

Psoriatic Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Psoriatic Juvenile Idiopathic Arthritis

Aliases & Descriptions for Psoriatic Juvenile Idiopathic Arthritis:

Name: Psoriatic Juvenile Idiopathic Arthritis 50 69
Juvenile Psoriatic Arthritis 50 56 69
Psoriasis-Related Juvenile Idiopathic Arthritis 50 56
Psoriasis-Related Jia 50 56
Juvenile Arthritis 69

Characteristics:

Orphanet epidemiological data:

56
psoriasis-related juvenile idiopathic arthritis
Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA85436
UMLS via Orphanet 70 C0409672
ICD10 via Orphanet 34 L40.5+ M09.0*

Summaries for Psoriatic Juvenile Idiopathic Arthritis

NIH Rare Diseases : 50 psoriatic juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and psoriasis. other signs and symptoms may include dactylitis (inflammation and swelling of an entire finger or toe); nail pitting or splitting; and eye problems. although the underlying cause of psoriatic juvenile idiopathic arthritis is currently unknown (idiopathic), it is thought to occur due to a combination of genetic and environmental factors. it is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. treatment usually involves different types of medications to help manage symptoms and/or physical therapy. last updated: 11/23/2015

MalaCards based summary : Psoriatic Juvenile Idiopathic Arthritis, also known as juvenile psoriatic arthritis, is related to psoriatic arthritis and arthritis. An important gene associated with Psoriatic Juvenile Idiopathic Arthritis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs Etanercept and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Psoriatic Juvenile Idiopathic Arthritis

Graphical network of the top 20 diseases related to Psoriatic Juvenile Idiopathic Arthritis:



Diseases related to Psoriatic Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Psoriatic Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Psoriatic Juvenile Idiopathic Arthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.26 NLRP3 NOD2 PSTPIP1 MEFV
2 immune system MP:0005387 8.92 MEFV NLRP3 NOD2 PSTPIP1

Drugs & Therapeutics for Psoriatic Juvenile Idiopathic Arthritis

Drugs for Psoriatic Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4,Phase 3 185243-69-0
2 Vaccines Phase 4
3 Immunoglobulins Phase 4,Phase 3
4 Antibodies Phase 4,Phase 3
5 Analgesics Phase 4,Phase 3
6 Gastrointestinal Agents Phase 4,Phase 3
7 Analgesics, Non-Narcotic Phase 4,Phase 3
8 Peripheral Nervous System Agents Phase 4,Phase 3
9 Immunosuppressive Agents Phase 4,Phase 3
10 Anti-Inflammatory Agents Phase 4,Phase 3
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
12 Antirheumatic Agents Phase 4,Phase 3
13
Tofacitinib Approved, Investigational Phase 3 477600-75-2
14
Certolizumab pegol Approved Phase 3 428863-50-7
15
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
16
Entecavir Approved, Investigational Phase 3 142217-69-4 153941
17
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
19 Pharmaceutical Solutions Phase 3
20 Protein Kinase Inhibitors Phase 3
21 Antibodies, Monoclonal Phase 3
22 Folic Acid Antagonists Phase 3
23 Nucleic Acid Synthesis Inhibitors Phase 3
24 Dermatologic Agents Phase 3
25 Vitamin B Complex Phase 3
26 Anti-Infective Agents Phase 3
27 Antimetabolites Phase 3
28 Antimetabolites, Antineoplastic Phase 3
29 Antiviral Agents Phase 3
30 Folate Nutraceutical Phase 3
31 Vitamin B9 Nutraceutical Phase 3
32 Rheumatoid Factor

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis Unknown status NCT00573651 Phase 4
2 Study Evaluating Etanercept in Patients With Rheumatoid Arthritis(RA), Juvenile Idiopathic Arthritis (JIA), or Psoriatic Arthritis (PsA) in Spain Completed NCT00195377 Phase 4
3 Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Completed NCT00962741 Phase 3
4 Long-Term Safety Study Of Tofacinib In Patients With Juvenile Idiopathic Arthritis Recruiting NCT01500551 Phase 3
5 Extension Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Active, not recruiting NCT01421069 Phase 3
6 Pediatric Arthritis Study of Certolizumab Pegol Active, not recruiting NCT01550003 Phase 3
7 Secukinumab Safety and Efficacy in JPsA and ERA Not yet recruiting NCT03031782 Phase 3
8 A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS) Terminated NCT01230827 Phase 3
9 Study of Anti-Viral Prophylaxis for HBsAg(+) or HBcAb(+)/HBsAb(-) Patients Starting Anti-TNF╬▒ Terminated NCT01694264 Phase 3
10 C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in France Completed NCT02886689
11 Organization of Teratology Information Services (OTIS) Autoimmune Diseases in Pregnancy Project Completed NCT00116272
12 Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry Recruiting NCT02418442

Search NIH Clinical Center for Psoriatic Juvenile Idiopathic Arthritis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Psoriatic Juvenile Idiopathic Arthritis

Anatomical Context for Psoriatic Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Psoriatic Juvenile Idiopathic Arthritis:

39
Eye, Bone

Publications for Psoriatic Juvenile Idiopathic Arthritis

Articles related to Psoriatic Juvenile Idiopathic Arthritis:

id Title Authors Year
1
Enthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity. ( 25774101 )
2015
2
Psoriatic juvenile idiopathic arthritis associated with uveitis: a case report. ( 24191219 )
2013
3
Psoriatic juvenile idiopathic arthritis: a tale of two subgroups. ( 21709556 )
2011
4
Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis. ( 18576390 )
2008

Variations for Psoriatic Juvenile Idiopathic Arthritis

Expression for Psoriatic Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Psoriatic Juvenile Idiopathic Arthritis.

Pathways for Psoriatic Juvenile Idiopathic Arthritis

GO Terms for Psoriatic Juvenile Idiopathic Arthritis

Cellular components related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.13 MEFV NOD2 PSTPIP1
2 lamellipodium GO:0030027 8.62 MEFV PSTPIP1

Biological processes related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 MEFV NLRP3 PSTPIP1
2 defense response GO:0006952 9.49 NLRP3 NOD2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.48 NLRP3 NOD2
4 negative regulation of inflammatory response GO:0050728 9.46 MEFV NLRP3
5 innate immune response GO:0045087 9.46 MEFV NLRP3 NOD2 PSTPIP1
6 regulation of inflammatory response GO:0050727 9.43 NLRP3 NOD2
7 protein oligomerization GO:0051259 9.4 NLRP3 NOD2
8 positive regulation of interleukin-1 beta secretion GO:0050718 9.32 NLRP3 NOD2
9 positive regulation of type 2 immune response GO:0002830 9.26 NLRP3 NOD2
10 immune system process GO:0002376 9.26 MEFV NLRP3 NOD2 PSTPIP1
11 detection of biotic stimulus GO:0009595 8.62 NLRP3 NOD2

Molecular functions related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 8.62 NLRP3 NOD2

Sources for Psoriatic Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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