MCID: PSR016
MIFTS: 21

Psoriatic Juvenile Idiopathic Arthritis malady

Rare diseases category

Summaries for Psoriatic Juvenile Idiopathic Arthritis

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MalaCards based summary: Psoriatic Juvenile Idiopathic Arthritis is related to arthritis and uveitis. An important gene associated with Psoriatic Juvenile Idiopathic Arthritis is MEFV (Mediterranean fever), and among its related pathways are NOD-like Receptor Signaling Pathways and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds endotoxin and mevalonate have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and hematopoietic system.

Aliases & Classifications for Psoriatic Juvenile Idiopathic Arthritis

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Psoriatic Juvenile Idiopathic Arthritis, Aliases & Descriptions:

Name: Psoriatic Juvenile Idiopathic Arthritis 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Psoriatic Juvenile Idiopathic Arthritis

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Diseases related to Psoriatic Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis29.9NOD2, NLRP3, MEFV, PSTPIP1
2uveitis10.3
3inflammatory bowel disease10.0NOD2, PSTPIP1
4familial mediterranean fever9.9NLRP3, MEFV
5familial cold autoinflammatory syndrome9.9NLRP3, MEFV
6chronic infantile neurological cutaneous articular syndrome9.9NLRP3, MEFV
7muckle-wells syndrome9.9NLRP3, MEFV
8arthropathy9.8NOD2, NLRP3
9dermatitis9.8NLRP3, NOD2
10blau syndrome9.7MEFV, NOD2, NLRP3
11pyoderma gangrenosum9.5NLRP3, PSTPIP1, NOD2, MEFV

Graphical network of diseases related to Psoriatic Juvenile Idiopathic Arthritis:



Diseases related to psoriatic juvenile idiopathic arthritis

Symptoms for Psoriatic Juvenile Idiopathic Arthritis

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Drugs & Therapeutics for Psoriatic Juvenile Idiopathic Arthritis

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Drug clinical trials:

Search ClinicalTrials for Psoriatic Juvenile Idiopathic Arthritis

Search NIH Clinical Center for Psoriatic Juvenile Idiopathic Arthritis

Genetic Tests for Psoriatic Juvenile Idiopathic Arthritis

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Anatomical Context for Psoriatic Juvenile Idiopathic Arthritis

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Animal Models for Psoriatic Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Psoriatic Juvenile Idiopathic Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.6MEFV, NLRP3, NOD2
2MP:00053977.9PSTPIP1, MEFV, NLRP3, NOD2
3MP:00053877.7PSTPIP1, MEFV, NLRP3, NOD2

Publications for Psoriatic Juvenile Idiopathic Arthritis

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Articles related to Psoriatic Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Psoriatic juvenile idiopathic arthritis associated with uveitis: a case report. (24191219)
2013
2
Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis. (18576390)
2008

Variations for Psoriatic Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Expression patterns in normal tissues for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Psoriatic Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Pathways related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
9.1NOD2, NLRP3
2
Show member pathways
8.0NOD2, NLRP3, MEFV, PSTPIP1

Compounds for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Sources:
44Novoseek
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Compounds related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1endotoxin449.4NOD2, MEFV
2mevalonate448.8NLRP3, MEFV

GO Terms for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Cellular components related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.0NOD2, NLRP3, MEFV, PSTPIP1

Biological processes related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-12 productionGO:0326959.6MEFV, NOD2
2detection of biotic stimulusGO:0095959.4NOD2, NLRP3
3positive regulation of interleukin-1 beta secretionGO:0507189.3NOD2, NLRP3
4protein oligomerizationGO:0512599.2NOD2, NLRP3
5defense responseGO:0069529.1NLRP3, NOD2
6positive regulation of NF-kappaB transcription factor activityGO:0510929.1NOD2, NLRP3
7negative regulation of NF-kappaB transcription factor activityGO:0320889.0NLRP3, NOD2
8negative regulation of inflammatory responseGO:0507288.8NLRP3, MEFV
9inflammatory responseGO:0069548.6PSTPIP1, MEFV, NLRP3
10nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358728.2MEFV, PSTPIP1, NLRP3, NOD2
11innate immune responseGO:0450878.2NLRP3, NOD2, PSTPIP1, MEFV

Molecular functions related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:0037799.3MEFV, PSTPIP1
2peptidoglycan bindingGO:0428348.8NOD2, NLRP3

Products for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Sources for Psoriatic Juvenile Idiopathic Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet