MCID: PSR016
MIFTS: 29

Psoriatic Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Psoriatic Juvenile Idiopathic Arthritis

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Sources:
31ICD10 via Orphanet, 48NIH Rare Diseases, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Psoriatic Juvenile Idiopathic Arthritis:

Name: Psoriatic Juvenile Idiopathic Arthritis 48 68
Juvenile Psoriatic Arthritis 48 54 68
 
Juvenile Arthritis 68

Characteristics:

Orphanet epidemiological data:

54
juvenile psoriatic arthritis:
Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet54 ORPHA85436
UMLS via Orphanet69 C0409672
ICD10 via Orphanet31 L40.5+, M09.0*

Summaries for Psoriatic Juvenile Idiopathic Arthritis

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NIH Rare Diseases:48 Psoriatic juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and psoriasis. Other signs and symptoms may include dactylitis (inflammation and swelling of an entire finger or toe); nail pitting or splitting; and eye problems. Although the underlying cause of psoriatic juvenile idiopathic arthritis is currently unknown (idiopathic), it is thought to occur due to a combination of genetic and environmental factors. It is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. Treatment usually involves different types of medications to help manage symptoms and/or physical therapy. Last updated: 11/23/2015

MalaCards based summary: Psoriatic Juvenile Idiopathic Arthritis, also known as juvenile psoriatic arthritis, is related to arthritis and familial cold-induced inflammatory syndrome 1, and has symptoms including pathergy reaction An important gene associated with Psoriatic Juvenile Idiopathic Arthritis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways are Immune System and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs aurothioglucose and etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Psoriatic Juvenile Idiopathic Arthritis

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Graphical network of diseases related to Psoriatic Juvenile Idiopathic Arthritis:



Diseases related to psoriatic juvenile idiopathic arthritis

Symptoms & Phenotypes for Psoriatic Juvenile Idiopathic Arthritis

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UMLS symptoms related to Psoriatic Juvenile Idiopathic Arthritis:


pathergy reaction

MGI Mouse Phenotypes related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.8MEFV, NLRP3, NOD2, PSTPIP1
2MP:00053878.0MEFV, NLRP3, NOD2, PSTPIP1

Drugs & Therapeutics for Psoriatic Juvenile Idiopathic Arthritis

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Drugs for Psoriatic Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etanerceptapproved, investigationalPhase 4, Phase 3397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
2VaccinesPhase 46428
3AntibodiesPhase 4, Phase 36045
4ImmunoglobulinsPhase 4, Phase 36045
5Immunosuppressive AgentsPhase 4, Phase 312770
6Peripheral Nervous System AgentsPhase 4, Phase 322776
7Antirheumatic AgentsPhase 4, Phase 310627
8Gastrointestinal AgentsPhase 4, Phase 38109
9Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 34295
10Analgesics, Non-NarcoticPhase 4, Phase 36260
11Anti-Inflammatory AgentsPhase 4, Phase 310355
12AnalgesicsPhase 4, Phase 311287
13
Entecavirapproved, investigationalPhase 3180142217-69-4153941
Synonyms:
142217-69-4
2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one--water (1/1)
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one
209216-23-9
6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]
9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)guanine monohydrate
AB1004838
AC-1593
AC1L4BEC
Anhydrous entecavir
BMS-200475
Baraclude
Baraclude (TN)
CHEBI:473990
CHEBI:59902
CHEMBL713
CID153941
 
D04008
D07896
DB00442
ETV
Entecavir
Entecavir (INN)
Entecavir (USAN)
Entecavir (anhydrous)
Entecavir anhydrous
Entecavir hydrate
Entecavir hydrate (JAN)
Entecavirum
FT-0083013
MolPort-005-942-963
S2128_Selleck
SBB066120
SQ-34676
TL8000933
ZINC03802690
entecavir monohydrate
14
Tofacitinibapproved, investigationalPhase 3104477600-75-2
Synonyms:
 
Tasocitinib
Tofacitinibum
15
Certolizumab pegolapprovedPhase 3122428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
D03441
cimzia
16
MethotrexateapprovedPhase 315181959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
17
Folic Acidapproved, nutraceutical, vet_approvedPhase 3427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
18Antiviral AgentsPhase 39732
19Anti-Infective AgentsPhase 321402
20Pharmaceutical SolutionsPhase 37793
21Protein Kinase InhibitorsPhase 33612
22Nucleic Acid Synthesis InhibitorsPhase 34855
23Vitamin B ComplexPhase 34229
24AntimetabolitesPhase 311774
25Folic Acid AntagonistsPhase 32200
26Antimetabolites, AntineoplasticPhase 37171
27Antibodies, MonoclonalPhase 33795
28Dermatologic AgentsPhase 35674
29Vitamin B9NutraceuticalPhase 34279
30Folinic AcidNutraceuticalPhase 33150
31FolateNutraceuticalPhase 34279
32Rheumatoid Factor6

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative ArthritisUnknown statusNCT00573651Phase 4
2Study Evaluating Etanercept in Patients With Rheumatoid Arthritis(RA), Juvenile Idiopathic Arthritis (JIA), or Psoriatic Arthritis (PsA) in SpainCompletedNCT00195377Phase 4
3Study of Anti-Viral Prophylaxis for HBsAg(+) or HBcAb(+)/HBsAb(-) Patients Starting Anti-TNFαUnknown statusNCT01694264Phase 3
4Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisCompletedNCT00962741Phase 3
5Long-Term Safety Study Of Tofacinib In Patients With Juvenile Idiopathic ArthritisRecruitingNCT01500551Phase 3
6Extension Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisActive, not recruitingNCT01421069Phase 3
7Pediatric Arthritis Study of Certolizumab PegolActive, not recruitingNCT01550003Phase 3
8Secukinumab Safety and Efficacy in JPsA and ERANot yet recruitingNCT03031782Phase 3
9A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS)TerminatedNCT01230827Phase 3
10C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in FranceCompletedNCT02886689
11Organization of Teratology Information Services (OTIS) Autoimmune Diseases in Pregnancy ProjectCompletedNCT00116272
12Observational Study of Pediatric Rheumatic Diseases: The CARRA RegistryRecruitingNCT02418442

Search NIH Clinical Center for Psoriatic Juvenile Idiopathic Arthritis

Inferred drug relations via UMLS68/NDF-RT46:

Genetic Tests for Psoriatic Juvenile Idiopathic Arthritis

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Anatomical Context for Psoriatic Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Psoriatic Juvenile Idiopathic Arthritis:

36
Bone

Publications for Psoriatic Juvenile Idiopathic Arthritis

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Articles related to Psoriatic Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Enthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity. (25774101)
2015
2
Psoriatic juvenile idiopathic arthritis associated with uveitis: a case report. (24191219)
2013
3
Psoriatic juvenile idiopathic arthritis: a tale of two subgroups. (21709556)
2011
4
Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis. (18576390)
2008

Variations for Psoriatic Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Psoriatic Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Pathways related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.0MEFV, NLRP3, NOD2, PSTPIP1
2
Show member pathways
8.0MEFV, NLRP3, NOD2, PSTPIP1

GO Terms for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Cellular components related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lamellipodiumGO:00300279.4MEFV, PSTPIP1
2cytosolGO:00058298.6MEFV, NLRP3, NOD2, PSTPIP1

Biological processes related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:00507289.9MEFV, NLRP3
2defense responseGO:00069529.7NLRP3, NOD2
3detection of biotic stimulusGO:00095959.7NLRP3, NOD2
4positive regulation of interleukin-1 beta secretionGO:00507189.6NLRP3, NOD2
5positive regulation of NF-kappaB transcription factor activityGO:00510929.6NLRP3, NOD2
6positive regulation of type 2 immune responseGO:00028309.6NLRP3, NOD2
7protein oligomerizationGO:00512599.5NLRP3, NOD2
8inflammatory responseGO:00069549.5MEFV, NLRP3, PSTPIP1
9innate immune responseGO:00450879.1NLRP3, NOD2, PSTPIP1
10regulation of inflammatory responseGO:00507279.0NLRP3, NOD2

Molecular functions related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:00428349.0NLRP3, NOD2

Sources for Psoriatic Juvenile Idiopathic Arthritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet