MCID: PSR016
MIFTS: 35

Psoriatic Juvenile Idiopathic Arthritis

Categories: Rare diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Psoriatic Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Psoriatic Juvenile Idiopathic Arthritis:

Name: Psoriatic Juvenile Idiopathic Arthritis 49 69
Juvenile Psoriatic Arthritis 49 55 69
Psoriasis-Related Juvenile Idiopathic Arthritis 49 55
Psoriasis-Related Jia 49 55
Juvenile Arthritis 69

Characteristics:

Orphanet epidemiological data:

55
psoriasis-related juvenile idiopathic arthritis
Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 55 ORPHA85436
UMLS via Orphanet 70 C0409672
ICD10 via Orphanet 33 L40.5+ M09.0*

Summaries for Psoriatic Juvenile Idiopathic Arthritis

NIH Rare Diseases : 49 Psoriatic juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and psoriasis. Other signs and symptoms may include dactylitis (inflammation and swelling of an entire finger or toe); nail pitting or splitting; and eye problems. Although the underlying cause of psoriatic juvenile idiopathic arthritis is currently unknown (idiopathic), it is thought to occur due to a combination of genetic and environmental factors. It is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. Treatment usually involves different types of medications to help manage symptoms and/or physical therapy. Last updated: 11/23/2015

MalaCards based summary : Psoriatic Juvenile Idiopathic Arthritis, also known as juvenile psoriatic arthritis, is related to arthritis and cervical adenitis. An important gene associated with Psoriatic Juvenile Idiopathic Arthritis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs Certolizumab pegol and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Psoriatic Juvenile Idiopathic Arthritis

Diseases related to Psoriatic Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 arthritis 10.2
2 cervical adenitis 9.9 MEFV NLRP3
3 familial cold autoinflammatory syndrome 1 9.9 MEFV NLRP3
4 erysipeloid 9.9 MEFV NLRP3
5 uveitis 9.9
6 periodic fever, familial, autosomal dominant 9.9 MEFV NLRP3
7 muckle-wells syndrome 9.8 MEFV NLRP3
8 cinca syndrome 9.8 MEFV NLRP3
9 wells syndrome 9.8 MEFV NLRP3
10 aphthous stomatitis 9.7 MEFV NLRP3
11 amyloidosis 9.5 MEFV NLRP3
12 lig4 syndrome 9.4 NLRP3 NOD2
13 pyoderma 9.4 MEFV NOD2 PSTPIP1
14 behcet syndrome 9.4 MEFV NOD2 PSTPIP1
15 blau syndrome 9.3 MEFV NLRP3 NOD2
16 pyoderma gangrenosum 9.0 MEFV NLRP3 NOD2 PSTPIP1
17 familial mediterranean fever 9.0 MEFV NLRP3 NOD2 PSTPIP1

Graphical network of the top 20 diseases related to Psoriatic Juvenile Idiopathic Arthritis:



Diseases related to Psoriatic Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Psoriatic Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Psoriatic Juvenile Idiopathic Arthritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.26 MEFV NLRP3 NOD2 PSTPIP1
2 immune system MP:0005387 8.92 MEFV NLRP3 NOD2 PSTPIP1

Drugs & Therapeutics for Psoriatic Juvenile Idiopathic Arthritis

Drugs for Psoriatic Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Certolizumab pegol Approved Phase 3 428863-50-7
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
5 Antibodies, Monoclonal Phase 3
6 Immunoglobulins Phase 3
7 Antibodies Phase 3
8 Pharmaceutical Solutions Phase 3
9 Immunosuppressive Agents Phase 3
10 Antirheumatic Agents Phase 3
11 Folic Acid Antagonists Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13 Dermatologic Agents Phase 3
14 Vitamin B Complex Phase 3
15 Antimetabolites Phase 3
16 Antimetabolites, Antineoplastic Phase 3
17 Folate Nutraceutical Phase 3
18 Vitamin B9 Nutraceutical Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Secukinumab Safety and Efficacy in JPsA and ERA Recruiting NCT03031782 Phase 3 AIN457
2 Pediatric Arthritis Study of Certolizumab Pegol Active, not recruiting NCT01550003 Phase 3 Certolizumab Pegol (CZP)
3 A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS) Terminated NCT01230827 Phase 3 CNTO 148 (Golimumab);Placebo;Methotrexate

Search NIH Clinical Center for Psoriatic Juvenile Idiopathic Arthritis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Psoriatic Juvenile Idiopathic Arthritis

Anatomical Context for Psoriatic Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Psoriatic Juvenile Idiopathic Arthritis:

38
Eye, Bone

Publications for Psoriatic Juvenile Idiopathic Arthritis

Articles related to Psoriatic Juvenile Idiopathic Arthritis:

# Title Authors Year
1
Enthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity. ( 25774101 )
2015
2
Psoriatic juvenile idiopathic arthritis associated with uveitis: a case report. ( 24191219 )
2013
3
Psoriatic juvenile idiopathic arthritis: a tale of two subgroups. ( 21709556 )
2011
4
Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis. ( 18576390 )
2008

Variations for Psoriatic Juvenile Idiopathic Arthritis

Expression for Psoriatic Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Psoriatic Juvenile Idiopathic Arthritis.

Pathways for Psoriatic Juvenile Idiopathic Arthritis

GO Terms for Psoriatic Juvenile Idiopathic Arthritis

Cellular components related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.13 MEFV NOD2 PSTPIP1
2 lamellipodium GO:0030027 8.62 MEFV PSTPIP1

Biological processes related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.61 MEFV NLRP3 PSTPIP1
2 innate immune response GO:0045087 9.56 MEFV NLRP3 NOD2 PSTPIP1
3 defense response GO:0006952 9.52 NLRP3 NOD2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.51 NLRP3 NOD2
5 negative regulation of inflammatory response GO:0050728 9.49 MEFV NLRP3
6 protein oligomerization GO:0051259 9.48 NLRP3 NOD2
7 regulation of inflammatory response GO:0050727 9.46 NLRP3 NOD2
8 immune system process GO:0002376 9.46 MEFV NLRP3 NOD2 PSTPIP1
9 positive regulation of interleukin-1 beta secretion GO:0050718 9.4 NLRP3 NOD2
10 positive regulation of type 2 immune response GO:0002830 9.37 NLRP3 NOD2
11 cellular response to peptidoglycan GO:0071224 9.32 NLRP3 NOD2
12 detection of biotic stimulus GO:0009595 8.96 NLRP3 NOD2
13 cytokine secretion involved in immune response GO:0002374 8.62 NLRP3 NOD2

Molecular functions related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.13 MEFV NLRP3 PSTPIP1
2 peptidoglycan binding GO:0042834 8.62 NLRP3 NOD2

Sources for Psoriatic Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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