MCID: PSR016
MIFTS: 21

Psoriatic Juvenile Idiopathic Arthritis malady

Rare diseases category
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Summaries for Psoriatic Juvenile Idiopathic Arthritis

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MalaCards: Psoriatic Juvenile Idiopathic Arthritis is related to arthritis and uveitis. An important gene associated with Psoriatic Juvenile Idiopathic Arthritis is MEFV (Mediterranean fever), and among its related pathways are NOD-like Receptor Signaling Pathways and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The compounds endotoxin and mevalonate have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and hematopoietic system.

Aliases & Classifications for Psoriatic Juvenile Idiopathic Arthritis

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43NIH Rare Diseases
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Classifications:

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Global: Rare diseases


Aliases & Descriptions:

psoriatic juvenile idiopathic arthritis 43


Related Diseases for Psoriatic Juvenile Idiopathic Arthritis

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17GeneCards, 18GeneDecks
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Diseases related to Psoriatic Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.5NOD2, NLRP3, MEFV, PSTPIP1
2uveitis10.3
3inflammatory bowel disease10.0NOD2, PSTPIP1
4familial mediterranean fever10.0NLRP3, MEFV
5familial cold autoinflammatory syndrome10.0NLRP3, MEFV
6chronic infantile neurological cutaneous articular syndrome10.0NLRP3, MEFV
7muckle-wells syndrome10.0NLRP3, MEFV
8arthropathy10.0NOD2, NLRP3
9dermatitis9.9NLRP3, NOD2
10blau syndrome9.9MEFV, NOD2, NLRP3
11pyoderma gangrenosum9.9NLRP3, PSTPIP1, NOD2, MEFV

Graphical network of diseases related to Psoriatic Juvenile Idiopathic Arthritis:



Diseases related to psoriatic juvenile idiopathic arthritis

Symptoms for Psoriatic Juvenile Idiopathic Arthritis

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Drugs & Therapeutics for Psoriatic Juvenile Idiopathic Arthritis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Psoriatic Juvenile Idiopathic Arthritis

Genetic Tests for Psoriatic Juvenile Idiopathic Arthritis

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Anatomical Context for Psoriatic Juvenile Idiopathic Arthritis

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Animal Models for Psoriatic Juvenile Idiopathic Arthritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Psoriatic Juvenile Idiopathic Arthritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.6NOD2, NLRP3, MEFV
2MP:00053977.9NOD2, NLRP3, MEFV, PSTPIP1
3MP:00053877.7PSTPIP1, MEFV, NLRP3, NOD2

Publications for Psoriatic Juvenile Idiopathic Arthritis

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52PubMed
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Articles related to Psoriatic Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Psoriatic juvenile idiopathic arthritis associated with uveitis: a case report. (24191219)
2013
2
Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis. (18576390)
2008

Variations for Psoriatic Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Psoriatic Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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50PathCards, 54R&D Systems, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1NOD2, NLRP3
2
Show member pathways
8.0NOD2, NLRP3, MEFV, PSTPIP1

Compounds for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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45Novoseek
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Compounds related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1endotoxin459.4NOD2, MEFV
2mevalonate458.8NLRP3, MEFV

GO Terms for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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16Gene Ontology
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Cellular components related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.0NOD2, NLRP3, MEFV, PSTPIP1

Biological processes related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-12 productionGO:0326959.6NOD2, MEFV
2detection of biotic stimulusGO:0095959.4NOD2, NLRP3
3positive regulation of interleukin-1 beta secretionGO:0507189.3NLRP3, NOD2
4protein oligomerizationGO:0512599.2NOD2, NLRP3
5defense responseGO:0069529.1NLRP3, NOD2
6positive regulation of NF-kappaB transcription factor activityGO:0510929.1NOD2, NLRP3
7negative regulation of NF-kappaB transcription factor activityGO:0320889.0NOD2, NLRP3
8negative regulation of inflammatory responseGO:0507288.8NLRP3, MEFV
9inflammatory responseGO:0069548.6NLRP3, MEFV, PSTPIP1
10nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358728.2NOD2, NLRP3, MEFV, PSTPIP1
11innate immune responseGO:0450878.2PSTPIP1, MEFV, NLRP3, NOD2

Molecular functions related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:0037799.3MEFV, PSTPIP1
2peptidoglycan bindingGO:0428348.8NOD2, NLRP3

Products for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Sources for Psoriatic Juvenile Idiopathic Arthritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet