MCID: PSR016
MIFTS: 31

Psoriatic Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Psoriatic Juvenile Idiopathic Arthritis

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Sources:
66UMLS, 46NIH Rare Diseases, 52Orphanet, 29ICD10 via Orphanet, 67UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Psoriatic Juvenile Idiopathic Arthritis:

Name: Psoriatic Juvenile Idiopathic Arthritis 46 66
Juvenile Psoriatic Arthritis 46 52 66
 
Juvenile Arthritis 66

Characteristics:

Orphanet epidemiological data:

52
juvenile psoriatic arthritis:
Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet52 ORPHA85436
ICD10 via Orphanet29 L40.5+, M09.0*
UMLS via Orphanet67 C0409672

Summaries for Psoriatic Juvenile Idiopathic Arthritis

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NIH Rare Diseases:46 Psoriatic juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and psoriasis. other signs and symptoms may include dactylitis (inflammation and swelling of an entire finger or toe); nail pitting or splitting; and eye problems. although the underlying cause of psoriatic juvenile idiopathic arthritis is currently unknown (idiopathic), it is thought to occur due to a combination of genetic and environmental factors. it is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. treatment usually involves different types of medications to help manage symptoms and/or physical therapy. last updated: 11/23/2015

MalaCards based summary: Psoriatic Juvenile Idiopathic Arthritis, also known as juvenile psoriatic arthritis, is related to psoriatic arthritis and arthritis, and has symptoms including pathergy reaction An important gene associated with Psoriatic Juvenile Idiopathic Arthritis is MEFV (Mediterranean Fever), and among its related pathways are Immune System and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs diclofenac and aurothioglucose have been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Psoriatic Juvenile Idiopathic Arthritis

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Graphical network of diseases related to Psoriatic Juvenile Idiopathic Arthritis:



Diseases related to psoriatic juvenile idiopathic arthritis

Symptoms for Psoriatic Juvenile Idiopathic Arthritis

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UMLS symptoms related to Psoriatic Juvenile Idiopathic Arthritis:


pathergy reaction

Drugs & Therapeutics for Psoriatic Juvenile Idiopathic Arthritis

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Drugs for Psoriatic Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EtanerceptPhase 4, Phase 3391185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
2
TofacitinibPhase 398477600-75-2
Synonyms:
 
Tasocitinib
Tofacitinibum
3
EntecavirPhase 3176142217-69-4153941
Synonyms:
142217-69-4
2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one--water (1/1)
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one
209216-23-9
6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]
9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)guanine monohydrate
AB1004838
AC-1593
AC1L4BEC
Anhydrous entecavir
BMS-200475
Baraclude
Baraclude (TN)
CHEBI:473990
CHEBI:59902
CHEMBL713
CID153941
 
D04008
D07896
DB00442
ETV
Entecavir
Entecavir (INN)
Entecavir (USAN)
Entecavir (anhydrous)
Entecavir anhydrous
Entecavir hydrate
Entecavir hydrate (JAN)
Entecavirum
FT-0083013
MolPort-005-942-963
S2128_Selleck
SBB066120
SQ-34676
TL8000933
ZINC03802690
entecavir monohydrate
4
Certolizumab pegolPhase 3119428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
D03441
cimzia
5
MethotrexatePhase 314961959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
6
Folic AcidNutraceuticalPhase 3414359-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
7FolateNutraceuticalPhase 34143

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Study Evaluating Etanercept in Patients With Rheumatoid Arthritis(RA), Juvenile Idiopathic Arthritis (JIA), or Psoriatic Arthritis (PsA) in SpainCompletedNCT00195377Phase 4
2Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative ArthritisRecruitingNCT00573651Phase 4
3Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisCompletedNCT00962741Phase 3
4Study of Anti-Viral Prophylaxis for HBsAg(+) or HBcAb(+)/HBsAb(-) Patients Starting Anti-TNFαRecruitingNCT01694264Phase 3
5Long-Term Safety Study Of Tofacinib In Patients With Juvenile Idiopathic ArthritisRecruitingNCT01500551Phase 3
6Pediatric Arthritis Study of Certolizumab PegolActive, not recruitingNCT01550003Phase 3
7Extension Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisActive, not recruitingNCT01421069Phase 3
8A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS)TerminatedNCT01230827Phase 3
9C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in FranceCompletedNCT02886689
10Organization of Teratology Information Services (OTIS) Autoimmune Diseases in Pregnancy ProjectCompletedNCT00116272
11Observational Study of Pediatric Rheumatic Diseases: The CARRA RegistryRecruitingNCT02418442

Search NIH Clinical Center for Psoriatic Juvenile Idiopathic Arthritis

Inferred drug relations via UMLS66/NDF-RT44:

Genetic Tests for Psoriatic Juvenile Idiopathic Arthritis

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Anatomical Context for Psoriatic Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Psoriatic Juvenile Idiopathic Arthritis:

34
Eye, Bone

Animal Models for Psoriatic Juvenile Idiopathic Arthritis or affiliated genes

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MGI Mouse Phenotypes related to Psoriatic Juvenile Idiopathic Arthritis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0MEFV, NLRP3, NOD2, PSTPIP1
2MP:00053877.9MEFV, NLRP3, NOD2, PSTPIP1

Publications for Psoriatic Juvenile Idiopathic Arthritis

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Articles related to Psoriatic Juvenile Idiopathic Arthritis:

idTitleAuthorsYear
1
Enthesitis as a component of dactylitis in psoriatic juvenile idiopathic arthritis: histology of an established clinical entity. (25774101)
2015
2
Psoriatic juvenile idiopathic arthritis associated with uveitis: a case report. (24191219)
2013
3
Psoriatic juvenile idiopathic arthritis: a tale of two subgroups. (21709556)
2011
4
Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis. (18576390)
2008

Variations for Psoriatic Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Psoriatic Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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GO Terms for genes affiliated with Psoriatic Juvenile Idiopathic Arthritis

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Cellular components related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lamellipodiumGO:00300279.6MEFV, PSTPIP1
2cytosolGO:00058298.0MEFV, NLRP3, NOD2, PSTPIP1

Biological processes related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:00507289.9MEFV, NLRP3
2detection of biotic stimulusGO:00095959.7NLRP3, NOD2
3positive regulation of interleukin-1 beta secretionGO:00507189.6NLRP3, NOD2
4positive regulation of type 2 immune responseGO:00028309.6NLRP3, NOD2
5defense responseGO:00069529.5NLRP3, NOD2
6positive regulation of NF-kappaB transcription factor activityGO:00510929.2NLRP3, NOD2
7protein oligomerizationGO:00512599.0NLRP3, NOD2
8inflammatory responseGO:00069548.9MEFV, NLRP3, PSTPIP1
9regulation of inflammatory responseGO:00507278.7NLRP3, NOD2
10innate immune responseGO:00450878.5NLRP3, NOD2, PSTPIP1

Molecular functions related to Psoriatic Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:00428349.0NLRP3, NOD2

Sources for Psoriatic Juvenile Idiopathic Arthritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet