MCID: PSY004
MIFTS: 69

Psychotic Disorder malady

Neuronal diseases category

Summaries for Psychotic Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Mental disorders include a wide range of problems, including anxiety disorders, including panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and phobias bipolar disorder depression mood disorders personality disorders psychotic disorders, including schizophrenia there are many causes of mental disorders. your genes and family history may play a role. your life experiences, such as stress or a history of abuse, may also matter. biological factors can also be part of the cause. a traumatic brain injury can lead to a mental disorder. a mother's exposure to viruses or toxic chemicals while pregnant may play a part. other factors may increase your risk, such as use of illegal drugs or having a serious medical condition like cancer. medications and counseling can help many mental disorders.

MalaCards: Psychotic Disorder, also known as psychotic disorders, is related to schizophrenia and personality disorder. An important gene associated with Psychotic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Arginine and proline metabolism and Monoamine Transport. The drugs chlorpromazine and lorazepam and the compounds m-chlorophenylpiperazine and MMDA have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Disease Ontology:8 A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.

Wikipedia:63 Psychosis (from the Greek ψυχή psyche, \"mind/soul\", and -ωσις -osis, \"abnormal condition or... more...

Aliases & Classifications for Psychotic Disorder

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8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 25ICD10
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Related Diseases for Psychotic Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Psychotic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 2177)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.9HTR2A, COMT
2personality disorder30.5SLC6A4, SLC6A3, MAOB, DRD4
3substance abuse30.5DRD4, SLC6A3, SLC6A4
4bipolar disorder30.5NOS1, SLC6A4, HTR2A, HTR3A
5narcolepsy30.5HTR2A, COMT
6mood disorder30.5NOS1, DRD4, SLC6A3, MAOB, HTR2A, HTR3A
7obesity30.4NOS1, SLC6A3, MAOB, DRD4, HTR2A, COMT
8schizoaffective disorder30.4COMT, HTR2A, DRD4, PRL, PRODH, SLC6A4
9intellectual disability30.4PAH
10anxiety disorder30.3SLC6A4, HTR2A, HTR3A, COMT, SLC6A3, MAOB
11epilepsy syndrome30.3MAOB, SLC6A3, NOS1, HTR3A
12dementia30.2COMT, NOS1, SLC6A3, CFI, MAOB, HTR2A
13alzheimer's disease30.2RGS4, MAOB, COMT, CHKB, DRD4, HTR2A
14eating disorder30.2SLC6A4
15phenylketonuria30.1PAH
16hepatitis30.1COMT
17alcohol dependence30.1SLC6A4, DRD4, HTR2A
18hyperprolactinemia30.1DRD4, PRL
19autistic disorder30.1HTR3A, HTR2A, SLC6A4
20obsessive-compulsive disorder30.1SLC6A4, DRD4, SLC6A3, HTR2A, HTR3A, COMT
21multiple system atrophy30.1SLC6A3, MAOB
22substance dependence30.1COMT, SLC6A4, DRD4, SLC6A3
23borderline personality disorder30.0SLC6A4
24nicotine dependence30.0DRD4, SLC6A4
25chronic fatigue syndrome30.0SLC6A4
26attention deficit hyperactivity disorder30.0SLC6A3, DRD4
27amyotrophic lateral sclerosis30.0MAOB, CHKB, NOS1, SLC6A3
28bulimia nervosa29.9COMT, HTR3A, SLC6A4, HTR2A
29antisocial personality disorder29.9HTR2A, GABRB2, SLC6A3, SLC6A4
30conduct disorder29.9SLC6A3, DRD4, SLC6A4, COMT
31hypertension29.9SELENBP1, SLC6A4
32alcohol abuse29.9SLC6A3, COMT, SLC6A4
33hypoglycemia29.9PRL, HTR2A, COMT
34irritable bowel syndrome29.9SLC6A4, HTR3A
35seasonal affective disorder29.9HTR2A, DRD4, SLC6A4
36mental retardation29.9PAH, COMT, HTR3A, CFI
37essential hypertension29.8HTR2A, COMT
38drug dependence29.8SLC6A4, SLC6A3
39parkinson's disease29.8COMT, MAOB, SLC6A3
40meningitis29.7CFI
41pathological gambling29.7SLC6A3, DRD4
42gilles de la tourette syndrome29.7DRD4, SLC6A3
43generalized anxiety disorder29.7SLC6A4, HTR2A, HTR3A
44ischemia29.7CHKB, MAOB, SLC6A3, NOS1
45panic disorder29.7SLC6A4, HTR3A
46heroin dependence29.7DRD4
47neuroleptic malignant syndrome29.6CHKB
48social phobia29.6COMT, HTR3A, SLC6A4
49toxic encephalopathy29.6MAOB, SLC6A3, SLC6A4
50anorexia nervosa29.6SLC6A4, PRL, HTR2A, HTR3A, COMT, DRD4

Graphical network of the top 20 diseases related to Psychotic Disorder:



Diseases related to psychotic disorder

Clinical Features for Psychotic Disorder

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Genetic Tests for Psychotic Disorder

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Anatomical Context for Psychotic Disorder

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32MalaCards
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MalaCards organs/tissues related to Psychotic Disorder:

32
Brain, Heart, Pituitary, Bone, Skin, Testes, Temporal lobe

Animal Models for Psychotic Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Psychotic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.5HTR2A, PRL, RGS4, SLC6A3, SLC6A4, NOS1
2MP:00053679.2COMT, HTR3A, MAOB, RGS4, CFI, NOS1
3MP:00036318.7COMT, HTR3A, DRD4, GABRB2, PRL, PRODH
4MP:00053768.7PRODH, PRL, GABRB2, DRD4, HTR3A, COMT
5MP:00053868.5PAH, COMT, HTR3A, HTR2A, DRD4, GABRB2

Publications for Psychotic Disorder

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Sources:
50PubMed
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Articles related to Psychotic Disorder:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
First-episode acute and transient psychotic disorder in Latvia: A 6-year follow-up study. (23383651)
2014
2
Psychotic versus non-psychotic major depressive disorder: a comparative naturalistic study. (23810143)
2013
3
The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. (23245702)
2013
4
The association between autism spectrum disorder and psychotic experiences in the Avon longitudinal study of parents and children (ALSPAC) birth cohort. (23880491)
2013
5
A two-factor structure of first rank symptoms in patients with a psychotic disorder. (23732016)
2013
6
Replicated Evidence of Absence of Association between Serum S100B and (Risk of) Psychotic Disorder. (24358202)
2013
7
Microstructural white matter alterations in psychotic disorder: a family-based diffusion tensor imaging study. (23523694)
2013
8
Obstetric complications as risk factors for schizophrenia spectrum psychoses in offspring of mothers with psychotic disorder. (23002182)
2013
9
Psychotic symptoms in patients with borderline personality disorder: prevalence and clinical management. (23168909)
2013
10
Wernicke's encephalopathy mimicking an acute psychotic disorder. (23224464)
2012
11
Craving for cannabis in patients with psychotic disorder, their non-affected siblings and healthy controls: psychometric analysis of the obsessive compulsive drug use scale. (22961922)
2012
12
Psychiatric comorbidities in temporal lobe epilepsy: possible relationships between psychotic disorders and involvement of limbic circuits. (23429818)
2012
13
Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders. (21908796)
2012
14
A Comparative Study on Alexithymia in Depressive, Somatoform, Anxiety, and Psychotic Disorders among Koreans. (23251195)
2012
15
Is acute and transient psychotic disorder (ATPD) mini schizophrenia? The evidence from phenomenology and epidemiology. (23114808)
2012
16
Effect of illegal substance use on cognitive function in individuals with a psychotic disorder: a review and meta-analysis. (22924618)
2012
17
Reflections on Asperger syndrome and comorbidity with psychotic disorders. (21404153)
2011
18
Psychotic symptoms in social anxiety disorder with bipolar-like progression. (21971789)
2011
19
Voltage-gated potassium channel/LGI1 antibody-associated encephalopathy may cause brief psychotic disorder. (21658353)
2011
20
Medication adherence and subjective weight perception in patients with first-episode psychotic disorder. (21983497)
2011
21
Elevated bilirubin in acute and transient psychotic disorder. (20178091)
2010
22
Shared obsessive-compulsive disorder: broadening the concept of shared psychotic disorder. (20815674)
2010
23
Cannabis abuse and severity of psychotic and affective disorders in Israeli psychiatric inpatients. (19932824)
2010
24
Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder. (18484081)
2009
25
Family-based association study of Neuregulin 1 with psychotic bipolar disorder. (19127563)
2009
26
Mobility limitations in persons with psychotic disorder: findings from a population-based survey. (18802653)
2009
27
Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features. (19268543)
2009
28
Acute disseminated encephalomyelitis presenting as acute psychotic disorder. (19129570)
2008
29
Psychosis risk for parents and siblings of Dutch and Moroccan-Dutch patients with non-affective psychotic disorder. (18541411)
2008
30
Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment. (17363961)
2007
31
Delusions incorporating cannabis use in dually diagnosed patients with a primary psychotic disorder. (17924247)
2007
32
Psychopathology factors in first-episode affective and non-affective psychotic disorders. (16762370)
2007
33
Cognitive impairment in schizoaffective disorder: a comparison with non-psychotic bipolar and healthy subjects. (17997724)
2007
34
Acute psychotic disorder after gastric bypass surgery: differential diagnosis and treatment. (16390883)
2006
35
Co-morbidity of select anxiety, affective, and psychotic disorders with cannabis dependence in Southwest California Indians. (17088227)
2006
36
Brief psychotic disorder mimicking the symptoms of cerebrovascular attack evoked by symptoms that symbolized death in a patient with terminal stage stomach cancer: case report and review of the literature. (16889327)
2006
37
Risk factors for completed suicide in schizophrenia and other chronic psychotic disorders: a case-control study. (16626940)
2006
38
Increased risk of psychotic disorder among immigrants in MalmAP: a 3-year first-contact study. (16116941)
2005
39
Understanding the genesis of psychotic disorder: issues in the prediction and prophylaxis of those at 'ultra-high risk'. (16238884)
2005
40
Childhood predictors of future psychiatric morbidity in offspring of mothers with psychotic disorder: results from the Helsinki High-Risk Study. (15684232)
2005
41
Is unawareness of psychotic disorder a neurocognitive or psychological defensiveness problem? (15885506)
2005
42
Predicting features of later development of schizophrenia among patients with acute and transient psychotic disorder. (15823159)
2005
43
A neuropsychological comparison of psychotic disorder following traumatic brain injury, traumatic brain injury without psychotic disorder, and schizophrenia. (15377737)
2004
44
Cumulative incidence of mental disorders among offspring of mothers with psychotic disorder. Results from the Helsinki High-Risk Study. (15231550)
2004
45
Premorbid functioning in early-onset psychotic disorders. (12921474)
2003
46
The relation of "acute and transient psychotic disorder" (ICD-10 F23) to bipolar schizoaffective disorder. (11886694)
2002
47
Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. (11448373)
2001
48
Psychotic disorder caused by a general medical condition, with delusions. Secondary "organic" delusional syndromes. (7659604)
1995
49
A case of psychotic mood disorder in an AIDS patient. (7788679)
1995
50
Flumazenil-induced psychotic disorder in hepatic encephalopathy. (1346834)
1992

Genetic Variations for Psychotic Disorder

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Expression for genes affiliated with Psychotic Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psychotic Disorder

Search GEO for disease gene expression data for Psychotic Disorder.

Pathways for genes affiliated with Psychotic Disorder

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Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Psychotic Disorder

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Psychotic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1m-chlorophenylpiperazine4410.4HTR3A, SLC6A4, PRL, HTR2A
2MMDA1110.4SLC6A3, SLC6A4, HTR2A, MAOB
3mcpp4410.4PRL, HTR2A, SLC6A4, HTR3A
4pindolol44 28 1112.3HTR3A, HTR2A, PRL, SLC6A4
5carbidopa44 2811.3MAOB, COMT, PRL, SLC6A3
6mdma4410.3SLC6A4, SLC6A3, PRL, MAOB
75-hydroxytryptophan4410.3SLC6A4, HTR3A, HTR2A, PRL
8mhpg4410.3COMT, MAOB, SLC6A4, DRD4, PRL
9methylphenidate44 49 1112.3MAOB, DRD4, COMT, SLC6A3, SLC6A4
10nefazodone44 49 1112.3HTR2A, SLC6A3, SLC6A4, HTR3A
11trimipramine49 44 1112.3PRL, SLC6A4, SLC6A3, HTR2A
12pramipexole44 49 28 1113.3SLC6A3, DRD4, HTR2A, COMT, PRL
13ropinirole44 1111.3HTR2A, MAOB, COMT, DRD4
14mirtazapine49 44 1112.2PRL, HTR2A, SLC6A4, HTR3A
15chlorpromazine44 28 49 1113.2HTR3A, HTR2A, DRD4, PRL, CHKB
16clomipramine44 49 1112.2SLC6A4, SLC6A3, PRL, HTR2A, HTR3A
17amitriptyline44 49 28 1113.2SLC6A4, SLC6A3, MAOB, HTR2A, HTR3A
18ziprasidone49 28 44 1113.2PRL, DRD4, HTR3A, HTR2A, RGS4
19fenfluramine28 44 1112.2PRL, HTR2A, HTR3A, SLC6A4
20bromocriptine28 44 1112.2HTR2A, SLC6A3, PRL, DRD4, COMT
21maoa4410.2DRD4, HTR2A, COMT, SLC6A3, SLC6A4, MAOB
22apomorphine44 28 1112.2SLC6A3, DRD4, MAOB, PRL, HTR2A, COMT
23mptp4410.1SLC6A3, MAOB, NOS1, COMT, SLC6A4
24methamphetamine44 49 1112.1SLC6A3, SLC6A4, NOS1, COMT, DRD4, MAOB
25imipramine44 49 28 11 2414.1SLC6A4, HTR2A, HTR3A, NOS1, SLC6A3, MAOB
26citalopram49 44 11 2413.1HTR2A, SLC6A4, SLC6A3, MAOB, PRL, HTR3A
27homovanillic acid44 2411.1PRL, SLC6A4, MAOB, COMT
28pergolide28 44 1112.1COMT, HTR2A, DRD4, PRL
29perphenazine49 28 44 1113.1PRL, RGS4, HTR2A, HTR3A
30quetiapine44 49 28 11 2414.1HTR3A, HTR2A, DRD4, PRL, RGS4, SLC6A3
31paroxetine44 49 28 1113.0COMT, SLC6A4, PRL, DRD4, HTR2A, HTR3A
32sertraline44 28 49 11 2414.0MAOB, SLC6A3, HTR3A, SLC6A4
33fluoxetine49 44 28 1113.0SLC6A4, NOS1, MAOB, PRL, HTR2A, HTR3A
34levodopa44 1111.0DRD4, COMT, PRL, PAH, SLC6A3, MAOB
35choline44 11 2412.0SLC6A4, MAOB, CHKB, COMT, NOS1, SLC6A3
36fluvoxamine44 49 1112.0HTR3A, SLC6A3, HTR2A, SLC6A4
37epinephrine44 11 2412.0COMT, MAOB, CHKB, PAH, PRL, DRD4
38gaba4410.0MAOB, ME2, SLC6A4, DRD4, HTR3A, NOS1
39cocaine44 1110.9DRD4, CHKB, COMT, PRL, MAOB, SLC6A3
40olanzapine49 44 28 11 2413.9HTR2A, HTR3A, COMT, SLC6A3, RGS4, CHKB
41haloperidol44 28 2 49 1113.9PRL, SLC6A4, DRD4, MAOB, SLC6A3, HTR3A
42clozapine44 28 49 1112.8NOS1, SLC6A4, SLC6A3, CHKB, PRL, DRD4
435-hydroxytryptamine449.8COMT, SLC6A3, PRL, DRD4, HTR2A, HTR3A
44risperidone28 44 49 59 11 2414.8SLC6A3, RGS4, CHKB, SLC6A4, COMT, HTR2A
45nicotine44 49 28 1112.7COMT, MAOB, SLC6A4, NOS1, DRD4, SLC6A3
46quinpirole44 2810.6DRD4, RGS4, SLC6A3, HTR2A
47valine449.6COMT, SLC6A4, NOS1, SLC6A3, DRD4, PAH
48norepinephrine44 11 2411.6DRD4, PRL, CHKB, MAOB, SLC6A3, SLC6A4
49glutamate449.6CHKB, MAOB, PRODH, SLC6A3, SLC6A4, NOS1
50dopamine44 28 11 2412.4PAH, COMT, HTR3A, HTR2A, RGS4, DRD4

GO Terms for genes affiliated with Psychotic Disorder

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16Gene Ontology
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Cellular components related to Psychotic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7HTR2A, DRD4, GABRB2, SLC6A3, SLC6A4, HTR3A
2cytosolGO:0058298.8SELENBP1, COMT, HTR2A, GABRB2, CHKB, CLINT1

Biological processes related to Psychotic Disorder according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.4SLC6A3, COMT
2monoamine transportGO:01584410.4SLC6A4, SLC6A3
3multicellular organismal response to stressGO:03355510.3NOS1, PRL
4regulation of dopamine metabolic processGO:04205310.3SLC6A3, DRD4
5neurotransmitter biosynthetic processGO:04213610.2PAH, NOS1, SLC6A3, COMT
6serotonin receptor signaling pathwayGO:00721010.1HTR2A, HTR3A
7response to lipopolysaccharideGO:03249610.1MAOB, PRL, COMT
8response to ethanolGO:04547110.1PRL, MAOB, SLC6A3
9synaptic transmissionGO:00726810.0COMT, HTR3A, HTR2A, GABRB2, SLC6A3
10negative regulation of potassium ion transportGO:0432679.9NOS1, HTR2A
11response to drugGO:0424939.9COMT, HTR2A, PRL, MAOB, SLC6A3, SLC6A4

Molecular functions related to Psychotic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.2SLC6A3, DRD4
2monoamine transmembrane transporter activityGO:00850410.2SLC6A4, SLC6A3
3drug bindingGO:00814410.0SLC6A3, DRD4, HTR2A
4serotonin bindingGO:0513789.9HTR2A, HTR3A

Products for genes affiliated with Psychotic Disorder

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Sources for Psychotic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet