MCID: PSY004
MIFTS: 62

Psychotic Disorder malady

Neuronal category

Summaries for Psychotic Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Mental disorders include a wide range of problems, including anxiety disorders, including panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and phobias bipolar disorder depression mood disorders personality disorders psychotic disorders, including schizophrenia there are many causes of mental disorders. your genes and family history may play a role. your life experiences, such as stress or a history of abuse, may also matter. biological factors can also be part of the cause. a traumatic brain injury can lead to a mental disorder. a mother's exposure to viruses or toxic chemicals while pregnant may play a part. other factors may increase your risk, such as use of illegal drugs or having a serious medical condition like cancer. medications and counseling can help many mental disorders.

MalaCards: Psychotic Disorder, also known as psychotic disorders, is related to narcolepsy and bipolar disorder. An important gene associated with Psychotic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Arginine and proline metabolism and Monoamine Transport. The drugs carbamazepine and chlorpromazine and the compounds m-chlorophenylpiperazine and MMDA have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Disease Ontology:8 A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.

Wikipedia:64 Psychosis (from the Greek ψυχή \"psyche\", for mind/soul, and -ωσις \"-osis\", for abnormal... more...

Aliases & Classifications for Psychotic Disorder

Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 61UMLS, 27ICD9CM, 25ICD10
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Related Diseases for Psychotic Disorder

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Psychotic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 2200)
idRelated DiseaseScoreTop Affiliating Genes
1narcolepsy30.5HTR2A, COMT
2bipolar disorder30.5HTR3A, HTR2A, SLC6A4, NOS1
3substance abuse30.5SLC6A4, SLC6A3, DRD4
4schizoaffective disorder30.5NOS1, SLC6A4, PRODH, PRL, DRD4, HTR2A
5anxiety disorder30.4COMT, HTR3A, HTR2A, MAOB, SLC6A3, SLC6A4
6alcohol dependence30.2SLC6A4, DRD4, HTR2A
7hyperprolactinemia30.2PRL, DRD4
8obsessive-compulsive disorder30.2COMT, HTR3A, HTR2A, DRD4, SLC6A3, SLC6A4
9phenylketonuria30.1PAH
10autistic disorder30.1HTR3A, HTR2A, SLC6A4
11substance dependence30.1SLC6A4, SLC6A3, DRD4, COMT
12borderline personality disorder30.1SLC6A4
13nicotine dependence30.0SLC6A4, DRD4
14alzheimer's disease30.0COMT, HTR2A, DRD4, CHKB, MAOB, RGS4
15chronic fatigue syndrome30.0SLC6A4
16attention deficit hyperactivity disorder30.0DRD4, SLC6A3
17blindness29.9MAOB
18wilson disease29.9SLC6A3
19alcohol abuse29.9SLC6A4, SLC6A3, COMT
20mental retardation29.9COMT, HTR3A, CFI, PAH
21hypoglycemia29.9COMT, HTR2A, PRL
22irritable bowel syndrome29.9HTR3A, SLC6A4
23seasonal affective disorder29.9HTR2A, DRD4, SLC6A4
24bulimia nervosa29.9COMT, HTR3A, HTR2A, SLC6A4
25antisocial personality disorder29.9SLC6A4, SLC6A3, GABRB2, HTR2A
26hyperprolinemia29.8PRODH
27conduct disorder29.8SLC6A4, SLC6A3, DRD4, COMT
28fibromyalgia29.8HTR2A, HTR3A, COMT, SLC6A4
29heroin dependence29.7DRD4
30neuroleptic malignant syndrome29.7CHKB
31pathological gambling29.7DRD4, SLC6A3
32parkinson's disease29.7SLC6A3, MAOB, COMT
33generalized anxiety disorder29.7SLC6A4, HTR2A, HTR3A
34toxic encephalopathy29.7MAOB, SLC6A3, SLC6A4
35panic disorder29.7SLC6A4, HTR3A
36deficiency anemia29.7NOS1, CHKB
37dyspepsia29.5HTR3A
38sudden infant death syndrome29.5HTR3A, HTR2A, SLC6A4
39social phobia29.5COMT, HTR3A, SLC6A4
40amyotrophic lateral sclerosis29.5CHKB, MAOB, SLC6A3, NOS1
41asthma29.5NOS1, CFI, CHKB, HTR2A
42anorexia nervosa29.5DRD4, HTR2A, HTR3A, COMT, PRL, SLC6A4
43huntington's disease29.5MAOB, SLC6A3, NOS1
44premature ejaculation29.3SLC6A4
45cocaine dependence29.3SLC6A4, SLC6A3
46serotonin syndrome29.3HTR2A, HTR3A
47microcephaly10.6
48mental retardation epilepsy10.5
49n syndrome10.5
50mental retardation, x-linked10.5

Graphical network of the top 20 diseases related to Psychotic Disorder:



Diseases related to psychotic disorder

Clinical Features for Psychotic Disorder

Genetic Tests for Psychotic Disorder

Anatomical Context for Psychotic Disorder

Animal Models for Psychotic Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Psychotic Disorder

Sources:
51PubMed
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Articles related to Psychotic Disorder:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
Insight in psychotic disorder: relation with psychopathology and frontal lobe function. (23711569)
2014
2
Antecedents of manic versus other first psychotic episodes in 263 bipolar I disorder patients. (23837831)
2013
3
Mortality and its determinants in people with psychotic disorder. (23257931)
2013
4
Smoking and suicidality in patients with a psychotic disorder. (24411712)
2013
5
Sudden death of father or sibling in early childhood increases risk for psychotic disorder. (23269226)
2013
6
Diffusion tensor imaging white matter endophenotypes in patients with schizophrenia or psychotic bipolar disorder and their relatives. (23771210)
2013
7
Evidence That Transition from Health to Psychotic Disorder Can Be Traced to Semi-Ubiquitous Environmental Effects Operating against Background Genetic Risk. (24223116)
2013
8
Bone mineral density as a marker of cumulative endogenous estrogen exposure: relationship to background genetic risk of psychotic disorder. (23194650)
2013
9
A case of diagnosing a long-standing psychotic disorder during medical withdrawal. (22494235)
2012
10
Pituitary volume, stress reactivity and genetic risk for psychotic disorder. (22130309)
2012
11
Mismanagement of Wilson's disease as psychotic disorder. (23326792)
2012
12
Shared psychotic disorder with sexual delusions. (22810994)
2012
13
Psychotic disorder due to phosphaturic mesenchymal tumor with mixed connective tissue variant. (22221727)
2012
14
Differentiating schizoaffective and bipolar I disorder in first-episode psychotic mania. (22846650)
2012
15
McLean-Harvard International First-Episode Project: two-year stability of ICD-10 diagnoses in 500 first-episode psychotic disorder patients. (20673546)
2011
16
Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interaction. (21305693)
2011
17
Spontaneous resolution of eosinophilic granuloma in a patient with a psychotic disorder. (24148635)
2010
18
Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders. (19910055)
2010
19
Valproate induced hypoactive delirium in a bipolar disorder patient with psychotic features]. (20204907)
2010
20
D. R. Bach et al.: Elevated bilirubin in acute and transient psychotic disorder. Pharmacopsychiatry 2010; 43: 12-16. (20821368)
2010
21
Psychotic-like experiences as overdetermined phenomena: when do they increase risk for psychotic disorder? (18963838)
2009
22
Is the incidence of psychotic disorder in decline? Epidemiological evidence from two decades of research. (18725359)
2009
23
The genetics of psychotic bipolar disorder. (18474212)
2008
24
Thyrotoxicosis after iodine contrast medium administration: rapid mood swing to mania and subsequent psychotic depression in a patient with bipolar disorder during lithium therapy. (18651349)
2008
25
Psychotic exacerbation in a patient with seizure disorder treated with vagus nerve stimulation. (18751641)
2008
26
A cross-cultural study of employers' concerns about hiring people with psychotic disorder: implications for recovery. (17522747)
2007
27
Symptoms at first contact for psychotic disorder: comparison between native Dutch and ethnic minorities. (17669627)
2007
28
Psychotic disorder in a patient with central and extrapontine myelinolysis. (17472602)
2007
29
Variation in the malic enzyme 2 gene: implications for the pharmacogenomics of psychotic disorders. (17638511)
2007
30
Analysis of TBX1 variation in patients with psychotic and affective disorders. (17622328)
2007
31
Limbic encephalitis manifesting as a psychotic disorder. (16810408)
2006
32
Brief psychotic disorder associated with Sturge-Weber syndrome. (16018933)
2005
33
Childhood growth and future development of psychotic disorder among Helsinki high-risk children. (15927804)
2005
34
Development of depressed mood predicts onset of psychotic disorder in individuals who report hallucinatory experiences. (15826348)
2005
35
Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects. (14675802)
2003
36
Psychotic disorder in a case with Hallervorden-Spatz disease. (14531762)
2003
37
Characteristics of psychotic disorder due to traumatic brain injury: an analysis of case studies in the literature. (11983787)
2002
38
The concordance of ICD-10 acute and transient psychosis and DSM-IV brief psychotic disorder. (11989997)
2002
39
Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features. (11136644)
2001
40
Clinical predictors of acute response with quetiapine in psychotic mood disorders. (10817103)
2000
41
Cavum veli interpositi and psychotic disorder in a monocygotic twin. (10853922)
2000
42
Prolactin-secreting pituitary adenoma in neuroleptic treated patients with psychotic disorder. (10738858)
2000
43
Serotonin transporter gene not associated with psychotic symptomatology of mood disorders. (10359482)
1999
44
Frontal lobe epilepsy presenting as a psychotic disorder with delusions and hallucinations: a case study. (18438324)
1999
45
Olanzapine in the treatment of depressive disorders with psychotic symptoms]. (10087520)
1999
46
Psychotic disorder after lamotrigine. (10935851)
1998
47
Association between different psychotic disorders and the DRD4 polymorphism, but no differences in the main ligand binding region of the DRD4 receptor protein compared to controls. (9353244)
1996
48
Use of risperidone in psychotic disorder following ischemic brain damage. (9231301)
1996
49
Therapy of a case of psychotic personality organization manifesting gender identity disorder. (1364185)
1992
50
Diagnostic concordance in functional psychosis revisited: a study of inter-relationships between alternative concepts of psychotic disorder. (1615104)
1992

Genetic Variations for Psychotic Disorder

Expression for genes affiliated with Psychotic Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Psychotic Disorder

Search GEO for disease gene expression data for Psychotic Disorder.

Pathways for genes affiliated with Psychotic Disorder

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 54Reactome
See all sources

Compounds for genes affiliated with Psychotic Disorder

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Psychotic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1m-chlorophenylpiperazine4510.4HTR3A, SLC6A4, PRL, HTR2A
2MMDA1110.4SLC6A3, SLC6A4, HTR2A, MAOB
3mcpp4510.4PRL, HTR2A, SLC6A4, HTR3A
4pindolol45 29 1112.3HTR3A, HTR2A, PRL, SLC6A4
5carbidopa45 2911.3MAOB, COMT, PRL, SLC6A3
6mdma4510.3SLC6A4, SLC6A3, PRL, MAOB
75-hydroxytryptophan4510.3SLC6A4, HTR3A, HTR2A, PRL
8mhpg4510.3COMT, MAOB, SLC6A4, DRD4, PRL
9methylphenidate45 50 1112.3MAOB, DRD4, COMT, SLC6A3, SLC6A4
10nefazodone45 50 1112.3HTR2A, SLC6A3, SLC6A4, HTR3A
11trimipramine50 45 1112.3PRL, SLC6A4, SLC6A3, HTR2A
12pramipexole45 50 29 1113.3SLC6A3, DRD4, HTR2A, COMT, PRL
13ropinirole45 1111.3HTR2A, MAOB, COMT, DRD4
14mirtazapine50 45 1112.2PRL, HTR2A, SLC6A4, HTR3A
15chlorpromazine45 29 50 1113.2HTR3A, HTR2A, DRD4, PRL, CHKB
16clomipramine45 50 1112.2SLC6A4, SLC6A3, PRL, HTR2A, HTR3A
17amitriptyline45 50 29 1113.2SLC6A4, SLC6A3, MAOB, HTR2A, HTR3A
18ziprasidone50 29 45 1113.2PRL, DRD4, HTR3A, HTR2A, RGS4
19fenfluramine29 45 1112.2PRL, HTR2A, HTR3A, SLC6A4
20bromocriptine29 45 1112.2HTR2A, SLC6A3, PRL, DRD4, COMT
21maoa4510.2DRD4, HTR2A, COMT, SLC6A3, SLC6A4, MAOB
22apomorphine45 29 1112.2SLC6A3, DRD4, MAOB, PRL, HTR2A, COMT
23mptp4510.1SLC6A3, MAOB, NOS1, COMT, SLC6A4
24methamphetamine45 50 1112.1SLC6A3, SLC6A4, NOS1, COMT, DRD4, MAOB
25imipramine45 50 29 11 2414.1SLC6A4, HTR2A, HTR3A, NOS1, SLC6A3, MAOB
26citalopram50 45 11 2413.1HTR2A, SLC6A4, SLC6A3, MAOB, PRL, HTR3A
27homovanillic acid45 2411.1PRL, SLC6A4, MAOB, COMT
28pergolide29 45 1112.1COMT, HTR2A, DRD4, PRL
29perphenazine50 29 45 1113.1PRL, RGS4, HTR2A, HTR3A
30quetiapine45 50 29 11 2414.1HTR3A, HTR2A, DRD4, PRL, RGS4, SLC6A3
31paroxetine45 50 29 1113.0COMT, SLC6A4, PRL, DRD4, HTR2A, HTR3A
32sertraline45 29 50 11 2414.0MAOB, SLC6A3, HTR3A, SLC6A4
33fluoxetine50 45 29 1113.0SLC6A4, NOS1, MAOB, PRL, HTR2A, HTR3A
34levodopa45 1111.0DRD4, COMT, PRL, PAH, SLC6A3, MAOB
35choline45 11 2412.0SLC6A4, MAOB, CHKB, COMT, NOS1, SLC6A3
36fluvoxamine45 50 1112.0HTR3A, SLC6A3, HTR2A, SLC6A4
37epinephrine45 11 2412.0COMT, MAOB, CHKB, PAH, PRL, DRD4
38gaba4510.0MAOB, ME2, SLC6A4, DRD4, HTR3A, NOS1
39cocaine45 1110.9DRD4, CHKB, COMT, PRL, MAOB, SLC6A3
40olanzapine50 45 29 11 2413.9HTR2A, HTR3A, COMT, SLC6A3, RGS4, CHKB
41haloperidol45 29 2 50 1113.9PRL, SLC6A4, DRD4, MAOB, SLC6A3, HTR3A
42clozapine45 29 50 1112.8NOS1, SLC6A4, SLC6A3, CHKB, PRL, DRD4
435-hydroxytryptamine459.8COMT, SLC6A3, PRL, DRD4, HTR2A, HTR3A
44risperidone29 45 50 60 11 2414.8SLC6A3, RGS4, CHKB, SLC6A4, COMT, HTR2A
45nicotine45 50 29 1112.7COMT, MAOB, SLC6A4, NOS1, DRD4, SLC6A3
46quinpirole45 2910.6DRD4, RGS4, SLC6A3, HTR2A
47valine459.6COMT, SLC6A4, NOS1, SLC6A3, DRD4, PAH
48norepinephrine45 11 2411.6DRD4, PRL, CHKB, MAOB, SLC6A3, SLC6A4
49glutamate459.6CHKB, MAOB, PRODH, SLC6A3, SLC6A4, NOS1
50dopamine45 29 11 2412.4PAH, COMT, HTR3A, HTR2A, RGS4, DRD4

GO Terms for genes affiliated with Psychotic Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Psychotic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7HTR2A, DRD4, GABRB2, SLC6A3, SLC6A4, HTR3A
2cytosolGO:0058298.8SELENBP1, COMT, HTR2A, GABRB2, CHKB, CLINT1

Biological processes related to Psychotic Disorder according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.4SLC6A3, COMT
2monoamine transportGO:01584410.4SLC6A4, SLC6A3
3multicellular organismal response to stressGO:03355510.3NOS1, PRL
4regulation of dopamine metabolic processGO:04205310.3SLC6A3, DRD4
5neurotransmitter biosynthetic processGO:04213610.2PAH, NOS1, SLC6A3, COMT
6serotonin receptor signaling pathwayGO:00721010.1HTR2A, HTR3A
7response to lipopolysaccharideGO:03249610.1MAOB, PRL, COMT
8response to ethanolGO:04547110.1PRL, MAOB, SLC6A3
9synaptic transmissionGO:00726810.0COMT, HTR3A, HTR2A, GABRB2, SLC6A3
10negative regulation of potassium ion transportGO:0432679.9NOS1, HTR2A
11response to drugGO:0424939.9COMT, HTR2A, PRL, MAOB, SLC6A3, SLC6A4

Molecular functions related to Psychotic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.2SLC6A3, DRD4
2monoamine transmembrane transporter activityGO:00850410.2SLC6A4, SLC6A3
3drug bindingGO:00814410.0SLC6A3, DRD4, HTR2A
4serotonin bindingGO:0513789.9HTR2A, HTR3A

Products for genes affiliated with Psychotic Disorder

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  • Lysates
  • Antibodies

Sources for Psychotic Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet