MCID: PSY004
MIFTS: 69

Psychotic Disorder malady

Neuronal diseases category

Summaries for Psychotic Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Mental disorders include a wide range of problems, including anxiety disorders, including panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and phobias bipolar disorder depression mood disorders personality disorders psychotic disorders, including schizophrenia there are many causes of mental disorders. your genes and family history may play a role. your life experiences, such as stress or a history of abuse, may also matter. biological factors can also be part of the cause. a traumatic brain injury can lead to a mental disorder. a mother's exposure to viruses or toxic chemicals while pregnant may play a part. other factors may increase your risk, such as use of illegal drugs or having a serious medical condition like cancer. medications and counseling can help many mental disorders.

MalaCards: Psychotic Disorder, also known as psychotic disorders, is related to schizophrenia and personality disorder. An important gene associated with Psychotic Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Arginine and proline metabolism and Monoamine Transport. The drugs chlorpromazine and lorazepam and the compounds m-chlorophenylpiperazine and MMDA have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Disease Ontology:8 A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.

Wikipedia:63 Psychosis (from the Greek ψυχή psyche, \"mind/soul\", and -ωσις -osis, \"abnormal condition or... more...

Aliases & Classifications for Psychotic Disorder

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 25ICD10
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Related Diseases for Psychotic Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Psychotic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 2177)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.9HTR2A, COMT
2personality disorder30.5SLC6A4, SLC6A3, MAOB, DRD4
3substance abuse30.5DRD4, SLC6A3, SLC6A4
4bipolar disorder30.5NOS1, SLC6A4, HTR2A, HTR3A
5narcolepsy30.5HTR2A, COMT
6mood disorder30.5NOS1, DRD4, SLC6A3, MAOB, HTR2A, HTR3A
7obesity30.4NOS1, SLC6A3, MAOB, DRD4, HTR2A, COMT
8schizoaffective disorder30.4COMT, HTR2A, DRD4, PRL, PRODH, SLC6A4
9intellectual disability30.4PAH
10anxiety disorder30.3SLC6A4, HTR2A, HTR3A, COMT, SLC6A3, MAOB
11epilepsy syndrome30.3MAOB, SLC6A3, NOS1, HTR3A
12dementia30.2COMT, NOS1, SLC6A3, CFI, MAOB, HTR2A
13alzheimer's disease30.2RGS4, MAOB, COMT, CHKB, DRD4, HTR2A
14eating disorder30.2SLC6A4
15phenylketonuria30.1PAH
16hepatitis30.1COMT
17alcohol dependence30.1SLC6A4, DRD4, HTR2A
18hyperprolactinemia30.1DRD4, PRL
19autistic disorder30.1HTR3A, HTR2A, SLC6A4
20obsessive-compulsive disorder30.1SLC6A4, DRD4, SLC6A3, HTR2A, HTR3A, COMT
21multiple system atrophy30.1SLC6A3, MAOB
22substance dependence30.1COMT, SLC6A4, DRD4, SLC6A3
23borderline personality disorder30.0SLC6A4
24nicotine dependence30.0DRD4, SLC6A4
25chronic fatigue syndrome30.0SLC6A4
26attention deficit hyperactivity disorder30.0SLC6A3, DRD4
27amyotrophic lateral sclerosis30.0MAOB, CHKB, NOS1, SLC6A3
28bulimia nervosa29.9COMT, HTR3A, SLC6A4, HTR2A
29antisocial personality disorder29.9HTR2A, GABRB2, SLC6A3, SLC6A4
30conduct disorder29.9SLC6A3, DRD4, SLC6A4, COMT
31hypertension29.9SELENBP1, SLC6A4
32alcohol abuse29.9SLC6A3, COMT, SLC6A4
33hypoglycemia29.9PRL, HTR2A, COMT
34irritable bowel syndrome29.9SLC6A4, HTR3A
35seasonal affective disorder29.9HTR2A, DRD4, SLC6A4
36mental retardation29.9PAH, COMT, HTR3A, CFI
37essential hypertension29.8HTR2A, COMT
38drug dependence29.8SLC6A4, SLC6A3
39parkinson's disease29.8COMT, MAOB, SLC6A3
40meningitis29.7CFI
41pathological gambling29.7SLC6A3, DRD4
42gilles de la tourette syndrome29.7DRD4, SLC6A3
43generalized anxiety disorder29.7SLC6A4, HTR2A, HTR3A
44ischemia29.7CHKB, MAOB, SLC6A3, NOS1
45panic disorder29.7SLC6A4, HTR3A
46heroin dependence29.7DRD4
47neuroleptic malignant syndrome29.6CHKB
48social phobia29.6COMT, HTR3A, SLC6A4
49toxic encephalopathy29.6MAOB, SLC6A3, SLC6A4
50anorexia nervosa29.6SLC6A4, PRL, HTR2A, HTR3A, COMT, DRD4

Graphical network of the top 20 diseases related to Psychotic Disorder:



Diseases related to psychotic disorder

Clinical Features for Psychotic Disorder

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Genetic Tests for Psychotic Disorder

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Anatomical Context for Psychotic Disorder

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32MalaCards
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MalaCards organs/tissues related to Psychotic Disorder:

32
Brain, Heart, Pituitary, Testes, Skin, Bone, Temporal lobe

Animal Models for Psychotic Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Psychotic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.5HTR2A, PRL, RGS4, SLC6A3, SLC6A4, NOS1
2MP:00053679.2COMT, HTR3A, MAOB, RGS4, CFI, NOS1
3MP:00036318.7COMT, HTR3A, DRD4, GABRB2, PRL, PRODH
4MP:00053768.7PRODH, PRL, GABRB2, DRD4, HTR3A, COMT
5MP:00053868.5PAH, COMT, HTR3A, HTR2A, DRD4, GABRB2

Publications for Psychotic Disorder

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Sources:
50PubMed
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Articles related to Psychotic Disorder:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
Adolescents with emotional, conduct and hyperkinetic disorders who are experiencing psychotic symptoms may be at increased risk of suicide attempt. (24419099)
2014
2
Beliefs about health, health risks and health expectations from the perspective of people with a psychotic disorder. (24039643)
2013
3
High rehospitalization rate in alcohol-induced psychotic disorder. (23111929)
2013
4
Is psychotic disorder associated with increased levels of craving for cannabis? An Experience Sampling study. (23330571)
2013
5
Family history of psychosis moderates early auditory cortical response abnormalities in non-psychotic bipolar disorder. (23941660)
2013
6
Disruption of Cortical Association Networks in Schizophrenia and Psychotic Bipolar Disorder. (24306091)
2013
7
Psychotic disorder is an independent risk factor for increased fasting glucose and waist circumference. (23795858)
2013
8
Psychotic Disorder in Neurodegeneration with Brain Iron Accumulation. (24047758)
2013
9
A web-based tool to support shared decision making for people with a psychotic disorder: randomized controlled trial and process evaluation. (24100091)
2013
10
Mitochondrial detachment of hexokinase 1 in mood and psychotic disorders: implications for brain energy metabolism and neurotrophic signaling. (22018957)
2012
11
Mood disorder with psychotic symptoms and overlooked skin lesions: the strange case of Mrs. O. (23160056)
2012
12
Mood disorder with mixed, psychotic features due to vitamin b12 deficiency in an adolescent: case report. (22726236)
2012
13
Should the term catatonia be explicitly included in the ICD-10 description of acute transient psychotic disorder F23.0? (21830848)
2012
14
TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders. (22832956)
2012
15
Perceived relational evaluation as a predictor of self-esteem and mood in people with a psychotic disorder. (22546063)
2012
16
Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features. (22341483)
2012
17
Identification of sialyltransferase 8B as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26. (22693595)
2012
18
Alcohol use and mismatch negativity in young patients with psychotic disorder. (22009194)
2011
19
Psychotic disorder as a manifestation of Graves' disease. (20833948)
2010
20
Developing a risk-model of time to first-relapse for children and adolescents with a psychotic disorder. (19155804)
2009
21
McLean-Harvard International First-Episode Project: two-year stability of DSM-IV diagnoses in 500 first-episode psychotic disorder patients. (19200422)
2009
22
Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders. (17976739)
2008
23
An exploratory analysis of neurocognition in methamphetamine-induced psychotic disorder and paranoid schizophrenia. (18541986)
2008
24
The utility of SELENBP1 gene expression as a biomarker for major psychotic disorders: replication in schizophrenia and extension to bipolar disorder with psychosis. (18163446)
2008
25
Use of medications to reduce cardiovascular risk among individuals with psychotic disorders and Type 2 diabetes. (18353616)
2008
26
Executive deficits in psychotic and bipolar disorders - implications for our understanding of schizoaffective disorder. (18083013)
2008
27
Back to the future: predicting and reshaping the course of psychotic disorder. (18180425)
2008
28
Cognitive insight and psychotic disorder: the impact of active delusions. (17092694)
2007
29
Remitting brief psychotic disorder in a 15-year-old male. (17136499)
2007
30
Psychotic disorder induced by oxybutynin: Presentation of two cases. (17163294)
2006
31
Psychotic spectrum disorders and alcohol abuse: a review of pharmacotherapeutic strategies and a report on the effectiveness of naltrexone and disulfiram. (16887890)
2006
32
Klinefelter's syndrome (XXY) as a genetic model for psychotic disorders. (15729733)
2005
33
Persistent psychotic disorder in an adolescent with a past history of butane gas dependence. (15589716)
2004
34
Clozapine in treatment-resistant patients with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder: a naturalistic 48-month follow-up study. (12716249)
2003
35
A comparison study of early non-psychotic deviant behavior in Afrikaner and US patients with schizophrenia or schizoaffective disorder. (12606014)
2003
36
Distigmine bromide induced acute psychotic disorder in a patient with multiple sclerosis. (14611928)
2003
37
Ecstasy-induced psychotic disorder: six-month follow-up study. (12065963)
2002
38
Brief psychotic disorder in a middle aged Nigerian following the terrorist attacks in America-case report. (12665285)
2002
39
Differentiating childhood-onset schizophrenia from psychotic mood disorders. (11589532)
2001
40
Changes in insurance coverage and extent of care during the two years after first hospitalization for a psychotic disorder. (11141534)
2001
41
Association study between cannabinoid receptor gene (CNR1) and pathogenesis and psychotic symptoms of mood disorders. (11353438)
2001
42
Treatment of inhalant-induced psychotic disorder with carbamazepine versus haloperidol. (9634163)
1998
43
Substance use among patients with a psychotic disorder in a psychiatric emergency room. (9057237)
1997
44
Course of adolescent psychotic disorder with schizoaffective episodes. (9112045)
1997
45
Psychotic disorder associated with isoniazid. (8961730)
1996
46
Shared psychotic disorder: a critical review of the literature. (8548718)
1995
47
In vivo D2 dopamine receptor density in psychotic and nonpsychotic patients with bipolar disorder. (7771917)
1995
48
The Effect of Somatoform Disorder and Paranoid Psychotic Role-Related Dissimulations as a Response Set on the MMPI-2 (9463502)
1994
49
Self-other differentiation among psychotic and conduct-disordered adolescents as measured by human figure drawings. (8483645)
1993
50
The concept of cycloid psychotic disorder. (3050983)
1988

Genetic Variations for Psychotic Disorder

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Expression for genes affiliated with Psychotic Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Psychotic Disorder

Search GEO for disease gene expression data for Psychotic Disorder.

Pathways for genes affiliated with Psychotic Disorder

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Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Psychotic Disorder

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Psychotic Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1m-chlorophenylpiperazine4410.4PRL, HTR2A, HTR3A, SLC6A4
2MMDA1110.4MAOB, HTR2A, SLC6A3, SLC6A4
3mcpp4410.4SLC6A4, PRL, HTR2A, HTR3A
4pindolol44 28 1112.3HTR3A, SLC6A4, PRL, HTR2A
5carbidopa44 2811.3SLC6A3, MAOB, COMT, PRL
6mdma4410.3MAOB, PRL, SLC6A4, SLC6A3
75-hydroxytryptophan4410.3PRL, HTR2A, HTR3A, SLC6A4
8mhpg4410.3COMT, MAOB, SLC6A4, DRD4, PRL
9nefazodone44 49 1112.3HTR3A, HTR2A, SLC6A3, SLC6A4
10methylphenidate44 49 1112.3MAOB, DRD4, COMT, SLC6A3, SLC6A4
11pramipexole44 49 28 1113.3SLC6A3, DRD4, HTR2A, COMT, PRL
12ropinirole44 1111.3HTR2A, DRD4, MAOB, COMT
13trimipramine49 44 1112.2PRL, HTR2A, SLC6A3, SLC6A4
14mirtazapine49 44 1112.2SLC6A4, HTR2A, HTR3A, PRL
15clomipramine44 49 1112.2HTR2A, HTR3A, SLC6A4, SLC6A3, PRL
16chlorpromazine44 28 49 1113.2CHKB, PRL, DRD4, HTR2A, HTR3A
17amitriptyline44 49 28 1113.2SLC6A4, MAOB, HTR3A, HTR2A, SLC6A3
18ziprasidone49 28 44 1113.2HTR3A, HTR2A, RGS4, PRL, DRD4
19bromocriptine28 44 1112.2PRL, DRD4, HTR2A, SLC6A3, COMT
20maoa4410.2DRD4, HTR2A, COMT, SLC6A3, SLC6A4, MAOB
21apomorphine44 28 1112.2SLC6A3, DRD4, MAOB, PRL, HTR2A, COMT
22fenfluramine28 44 1112.2HTR2A, PRL, SLC6A4, HTR3A
23pergolide28 44 1112.1PRL, DRD4, HTR2A, COMT
24mptp4410.1SLC6A3, COMT, NOS1, SLC6A4, MAOB
25methamphetamine44 49 1112.1SLC6A3, SLC6A4, NOS1, COMT, DRD4, MAOB
26imipramine44 49 28 11 2414.1SLC6A4, SLC6A3, HTR3A, HTR2A, MAOB, NOS1
27citalopram49 44 11 2413.1HTR2A, SLC6A4, SLC6A3, MAOB, PRL, HTR3A
28perphenazine49 28 44 1113.1RGS4, PRL, HTR3A, HTR2A
29quetiapine44 49 28 11 2414.1HTR3A, HTR2A, DRD4, PRL, RGS4, SLC6A3
30homovanillic acid44 2411.1PRL, SLC6A4, COMT, MAOB
31paroxetine44 49 28 1113.0COMT, SLC6A4, PRL, DRD4, HTR2A, HTR3A
32sertraline44 28 49 11 2414.0HTR3A, MAOB, SLC6A3, SLC6A4
33fluoxetine49 44 28 1113.0SLC6A4, NOS1, MAOB, PRL, HTR2A, HTR3A
34levodopa44 1111.0DRD4, COMT, PRL, PAH, SLC6A3, MAOB
35choline44 11 2412.0COMT, NOS1, SLC6A4, SLC6A3, MAOB, CHKB
36epinephrine44 11 2412.0COMT, DRD4, PRL, MAOB, SLC6A4, PAH
37gaba4410.0ME2, HTR3A, DRD4, SLC6A3, NOS1, SLC6A4
38quinpirole44 2810.9HTR2A, DRD4, RGS4, SLC6A3
39cocaine44 1110.9DRD4, CHKB, COMT, PRL, MAOB, SLC6A3
40olanzapine49 44 28 11 2413.9HTR2A, HTR3A, COMT, SLC6A3, RGS4, CHKB
41haloperidol44 28 2 49 1113.9PRL, SLC6A4, DRD4, MAOB, SLC6A3, HTR3A
42clozapine44 28 49 1112.8NOS1, SLC6A4, SLC6A3, CHKB, PRL, DRD4
435-hydroxytryptamine449.8COMT, SLC6A3, PRL, DRD4, HTR2A, HTR3A
44risperidone28 44 49 59 11 2414.8SLC6A3, RGS4, CHKB, SLC6A4, COMT, HTR2A
45nicotine44 49 28 1112.7SLC6A3, DRD4, COMT, SLC6A4, MAOB, NOS1
46venlafaxine49 44 11 2412.7HTR2A, HTR3A, SLC6A3, SLC6A4
47valine449.6DRD4, COMT, SLC6A3, NOS1, SLC6A4, PAH
48norepinephrine44 11 2411.6DRD4, PRL, CHKB, MAOB, SLC6A3, SLC6A4
49glutamate449.6NOS1, SLC6A4, RGS4, MAOB, CHKB, PRODH
50dopamine44 28 11 2412.4PAH, COMT, HTR3A, HTR2A, RGS4, DRD4

GO Terms for genes affiliated with Psychotic Disorder

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16Gene Ontology
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Cellular components related to Psychotic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.7HTR2A, DRD4, GABRB2, SLC6A3, SLC6A4, HTR3A
2cytosolGO:0058298.8SELENBP1, COMT, HTR2A, GABRB2, CHKB, CLINT1

Biological processes related to Psychotic Disorder according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.4SLC6A3, COMT
2monoamine transportGO:01584410.4SLC6A4, SLC6A3
3multicellular organismal response to stressGO:03355510.3NOS1, PRL
4regulation of dopamine metabolic processGO:04205310.3SLC6A3, DRD4
5neurotransmitter biosynthetic processGO:04213610.2PAH, NOS1, SLC6A3, COMT
6serotonin receptor signaling pathwayGO:00721010.1HTR2A, HTR3A
7response to lipopolysaccharideGO:03249610.1MAOB, PRL, COMT
8response to ethanolGO:04547110.1PRL, MAOB, SLC6A3
9synaptic transmissionGO:00726810.0COMT, HTR3A, HTR2A, GABRB2, SLC6A3
10negative regulation of potassium ion transportGO:0432679.9NOS1, HTR2A
11response to drugGO:0424939.9COMT, HTR2A, PRL, MAOB, SLC6A3, SLC6A4

Molecular functions related to Psychotic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.2SLC6A3, DRD4
2monoamine transmembrane transporter activityGO:00850410.2SLC6A4, SLC6A3
3drug bindingGO:00814410.0SLC6A3, DRD4, HTR2A
4serotonin bindingGO:0513789.9HTR2A, HTR3A

Products for genes affiliated with Psychotic Disorder

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Sources for Psychotic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet