MCID: PTR004
MIFTS: 43

Pterygium malady

Genetic diseases (common), Eye diseases categories
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Summaries for Pterygium

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MalaCards based summary: Pterygium is related to popliteal pterygium syndrome and multiple pterygium syndrome lethal type. An important gene associated with Pterygium is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are NF-kappaB Signaling and Agrin Interactions at Neuromuscular Junction. The compounds acetylcholine and galantamine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related mouse phenotypes are integument and respiratory system.

Aliases & Classifications for Pterygium

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Pterygium, Aliases & Descriptions:

Name: Pterygium 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:0002116
MeSH34 D011625

Related Diseases for Pterygium

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Diseases in the Central Pterygium family:

pterygium Multiple Pterygium Syndrome, Dominant

Diseases related to Pterygium via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1popliteal pterygium syndrome31.9IRF6
2multiple pterygium syndrome lethal type30.9CHRND, CHRNG, CHRNA1
3fetal akinesia deformation sequence30.6RAPSN
4multiple pterygium syndrome escobar type10.6
5pinguecula10.5
6antecubital pterygium10.5
7endotheliitis10.4
8scleritis10.4
9popliteal pterygium syndrome lethal type10.3
10van der woude syndrome10.3
11multiple pterygium syndrome aslan type10.3
12popliteal pterygium syndrome 2, lethal type10.3
13congenital myasthenic syndrome10.3CHRNA1, CHRNG
14astigmatism10.3
15nicotine dependence10.2CHRNB1
16cataract10.2
17multiple pterygium syndrome x-linked10.2
18pterygium of the conjunctiva and cornea10.2
19pterygium colli - intellectual disability - digital anomalies10.2
20myasthenic syndrome, fast-channel congenital10.2CHRND, CHRNA1
21myasthenia gravis10.2RAPSN, CHRNA1
22progressive peripheral pterygium10.2
23pterygium of the conjunctiva, familial form10.2
24autosomal dominant multiple pterygium syndrome10.2
25cystic lymphangioma10.1CHRNG, CHRND
26burns10.1
27central pterygium10.1
28double pterygium10.1
29keratitis10.1
30pterygium colli mental retardation digital anomalies10.1
31spondylohypoplasia, arthrogryposis and popliteal pterygium10.1
32popliteal pterygium syndrome 110.1
33x-linked lethal multiple pterygium syndrome10.1
34congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.1CHRNB1, RAPSN
35nail-patella syndrome10.0
36cleft lip10.0
37xeroderma pigmentosum10.0
38achondrogenesis type ia10.0
39conjunctivochalasis10.0
40cervicitis10.0
41endophthalmitis10.0
42esotropia10.0
43leprosy10.0
44turner syndrome10.0
45noonan syndrome 110.0
46multiple pterygium syndrome, dominant10.0
47chrna1-related multiple pterygium syndrome, lethal type10.0
48chrnd-related multiple pterygium syndrome, lethal type10.0
49onychomatricoma10.0
50slow-channel congenital myasthenic syndrome10.0CHRNB1, CHRNA1, CHRND

Graphical network of the top 20 diseases related to Pterygium:



Diseases related to pterygium

Symptoms for Pterygium

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Drugs & Therapeutics for Pterygium

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Drug clinical trials:

Search ClinicalTrials for Pterygium

Search NIH Clinical Center for Pterygium

Genetic Tests for Pterygium

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Anatomical Context for Pterygium

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MalaCards organs/tissues related to Pterygium:

32
Eye, Endothelial, Testes, Kidney, Lung, Thyroid, Myeloid

Animal Models for Pterygium or affiliated genes

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MGI Mouse Phenotypes related to Pterygium:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0RIPK4, KRT4, CHRNG, IRF6
2MP:00053888.6AQP5, CHRNG, RAPSN, RIPK4
3MP:00053818.3AQP5, IRF6, KRT4, RIPK4
4MP:00107687.5RIPK4, AQP5, IRF6, CHRNA1, CHRNG, RAPSN

Publications for Pterygium

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Articles related to Pterygium:

(show top 50)    (show all 623)
idTitleAuthorsYear
1
Reducing postoperative pterygium recurrence: comparison of free conjunctival auto-graft and conjunctival rotation flap techniques. (25327918)
2014
2
Secondary nerve lengthening to obtain full knee extension in popliteal pterygium syndrome. (24683134)
2014
3
Epidemiology and Associated Morbidity of Pterygium: A Large, Community-Based Case-Control Study. (25392263)
2014
4
Peroxiredoxin I and II in Human Eyes: Cellular Distribution and Association with Pterygium and DNA Damage. (24152995)
2014
5
Sutureless and glue free limbal conjunctival auto graft for primary pterygium surgery. (23584665)
2013
6
Investigation of trace elements in pterygium tissue. (23432702)
2013
7
Comparison of wide conjunctival flap and conjunctival autografting techniques in pterygium surgery. (23533701)
2013
8
The association of Klinefelter syndrome and multiple pterygium syndrome: an unusual presentation. (24382544)
2013
9
Prevalence of pterygium in a population in Northern Japan: the Locomotive Syndrome and Health Outcome in Aizu Cohort Study. (23552021)
2013
10
Ocular demodicosis as a risk factor of pterygium recurrence. (23664471)
2013
11
Preoperative factors influencing success in pterygium surgery. (22873737)
2012
12
Effects of pterygium surgery on front and back corneal astigmatism. (23036543)
2012
13
New approach for pterygium removal using 20A % ethanol. (22717949)
2012
14
Randomized trial of pterygium surgery with mitomycin C application using conjunctival autograft versus conjunctival-limbal autograft. (22153864)
2012
15
Randomized controlled trial of subconjunctival bevacizumab injection in impending recurrent pterygium: a pilot study. (22081150)
2012
16
Anesthetic management of a pregnant patient with multiple pterygium syndrome (Escobar type). (22325835)
2012
17
Topical dobesilate eye drops for ophthalmic primary pterygium. (22605609)
2012
18
Anesthetic approach to a patient with multiple pterygium (Escobar) syndrome. (22486906)
2012
19
Topical cyclosporine A administration after pterygium surgery. (21725937)
2012
20
Effects of pterygium surgery on front and back corneal surfaces and anterior segment parameters. (22484701)
2012
21
Comparison of conjunctival autograft transplantation and amniotic membrane transplantation for pterygium: a meta-analysis. (21935607)
2012
22
The effect of topical 0.05% cyclosporine on recurrence following pterygium surgery. (21760716)
2011
23
Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits cell proliferation of pterygium fibroblasts. (21270971)
2011
24
Prevalence of pinguecula and pterygium in a general population in Spain. (21183945)
2011
25
Subconjunctival bevacizumab injection in treatment of pterygium. (21681707)
2011
26
Cosmesis after pterygium extended removal followed by extended conjunctival transplant as assessed by a new, web-based grading system. (21640383)
2011
27
The nuclear-factor kappaB pathway is activated in pterygium. (20811049)
2011
28
Troglitazone induced apoptosis of human pterygium fibroblasts through a mitochondrial-dependent pathway. (22553629)
2011
29
Long-term follow-up of pterygium surgery using a conjunctival autograft and Tissucol. (20861727)
2011
30
Effects of Pterygium on Ocular Aberrations. (20697274)
2010
31
Comparison of fibrin glue and suture technique in pterygium surgery performed with limbal autograft. (22553582)
2010
32
Endothelial cell loss during pterygium surgery: importance of timing of mitomycin C application. (19654528)
2009
33
The effect of mitomycin C on corneal endothelium in pterygium surgery. (18992871)
2009
34
Pterygium recurrence after excision with conjunctival autograft: a comparison of fibrin tissue adhesive to absorbable sutures. (19092404)
2009
35
Recurrent pterygium surgery using pterygium extended removal followed by extended conjunctival transplant: recurrence rate and cosmesis. (19576496)
2009
36
Invasive squamous cell carcinoma of the conjunctiva first misdiagnosed as a pterygium: a clinicopathologic case report. (18463488)
2008
37
Results of pterygium surgery using a biologic adhesive. (18580257)
2008
38
Nine-year incidence and risk factors for pterygium in the barbados eye studies. (18930552)
2008
39
The prevalence, severity and risk factors for pterygium in central Myanmar: the Meiktila Eye Study. (18055574)
2008
40
Familial multiple pterygium syndrome (MPS) is not associated with CHRNG gene mutation. (17431910)
2007
41
Blood vessel multiply and significance of expression of Cox-2, VEGF in pterygium]. (17444036)
2007
42
Surgical technique for recurrent pterygium. (16877085)
2006
43
Trefoil factor family mRNA and protein expression in pterygium. (16142316)
2005
44
The abnormal expression of interleukine-1 family in pterygium]. (12870354)
2003
45
Gene symbol IRF6. Disease: Van der Woude syndrome and popliteal pterygium. (14640121)
2003
46
Popliteal pterygium associated with neonatal Marfan syndrome: case report. (11446416)
2001
47
Molecular genetic alterations and viral presence in ophthalmic pterygium. (10851263)
2000
48
Antecubital pterygium and cleft lip/palate presenting as signs of the nail-patella syndrome: report of a Brazilian family. (2012138)
1991
49
An incomplete form of the popliteal pterygium syndrome? (6595011)
1984
50
Popliteal pterygium syndrome. Evidence for a severe autosomal recessive form. (4339984)
1972

Variations for Pterygium

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Expression for genes affiliated with Pterygium

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Expression patterns in normal tissues for genes affiliated with Pterygium

Search GEO for disease gene expression data for Pterygium.

Pathways for genes affiliated with Pterygium

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Pathways related to Pterygium according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IRF6, RIPK4
29.6CHRNA1, RAPSN
3
Show member pathways
9.5CHRNA1, CHRNB1
4
Show member pathways
9.4CHRND, CHRNA1, CHRNG
5
Show member pathways
9.4CHRNA1, CHRND, CHRNG
6
Show member pathways
9.4CHRNA1, CHRND, CHRNG
7
Show member pathways
8.9CHRNB1, CHRNA1, CHRND, CHRNG
88.9CHRNB1, CHRNA1, CHRND, CHRNG
9
Show member pathways
8.3CHRNG, CHRND, CHRNA1, CHRNB1, AQP5

Compounds for genes affiliated with Pterygium

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Sources:
44Novoseek, 50PharmGKB, 28IUPHAR, 24HMDB, 11DrugBank
See all sources

Compounds related to Pterygium according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1acetylcholine44 50 28 24 1113.3RAPSN, CHRND, CHRNA1
2galantamine44 50 1110.6CHRNG, CHRND, CHRNA1, CHRNB1

GO Terms for genes affiliated with Pterygium

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Cellular components related to Pterygium according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuromuscular junctionGO:0315949.5CHRNA1, RAPSN
2intermediate filamentGO:0058829.1KRT4, KRT3
3acetylcholine-gated channel complexGO:0058929.0CHRNB1, CHRNG, CHRND, CHRNA1
4keratin filamentGO:0450958.8KRT4, KRT3
5postsynaptic membraneGO:0452118.5RAPSN, CHRNG, CHRND, CHRNB1, CHRNA1
6cell junctionGO:0300548.4CHRNB1, CHRNA1, RAPSN, CHRNG, CHRND

Biological processes related to Pterygium according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1skeletal muscle tissue growthGO:04863010.0CHRND, CHRNA1
2musculoskeletal movementGO:0508819.9CHRNA1, CHRND
3neuromuscular processGO:0509059.9CHRNA1, CHRND
4neuromuscular synaptic transmissionGO:0072749.7CHRNB1, CHRNA1
5synaptic transmission, cholinergicGO:0072719.6RAPSN, CHRNB1
6muscle contractionGO:0069369.5CHRNG, CHRND, CHRNB1
7cation transportGO:0068129.5CHRNB1, CHRNA1, CHRND
8transportGO:0068109.4CHRNG, CHRND, CHRNA1
9regulation of membrane potentialGO:0423919.2CHRNG, CHRND, CHRNA1, CHRNB1
10synaptic transmissionGO:0072689.1CHRNA1, CHRND, CHRNG, RAPSN
11transmembrane transportGO:0550859.0CHRNG, CHRNB1, AQP5
12epithelial cell differentiationGO:0308558.8KRT3, KRT4
13signal transductionGO:0071658.8CHRNB1, CHRNA1, CHRND, CHRNG

Molecular functions related to Pterygium according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1channel activityGO:0152679.7CHRNG, CHRNB1
2acetylcholine bindingGO:0421669.1CHRNB1, CHRNA1, CHRND
3acetylcholine receptor activityGO:0154648.9CHRNG, CHRNA1, CHRNB1
4acetylcholine-activated cation-selective channel activityGO:0048898.9CHRNG, CHRND, CHRNA1, CHRNB1

Products for genes affiliated with Pterygium

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  • Antibodies
  • Proteins
  • Lysates

Sources for Pterygium

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet