Pterygium malady

MalaCards: Pterygium is related to multiple pterygium syndrome escobar type and corneal disease. An important gene associated with Pterygium is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Glioma Invasiveness and Breast Cancer Regulation by Stathmin1. The compounds sp 600125 and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include t cells and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Descriptions:

pterygium 6 43

Diseases related to pterygium by text searches and GeneDecks gene sharing:

(show top 50)    (show all 855)

id	Related Disease	Score	Top Affiliating Genes
1	multiple pterygium syndrome escobar type	34.8	RAPSN, CHRND, CHRNB1, CHRNG
2	corneal disease	28.3	IL1A, KRT3, TIMP1, TFF3, CHRNG
3	cholesterol	16.8	KITLG, VWF, VEGFA, BMP6, RAPSN, BIRC5
4	fetal akinesia deformation sequence	14.0	RAPSN, CHRND, CHRNG
5	congenital myasthenic syndrome	13.9	RAPSN, CHRND, CHRNB1
6	peutz-jeghers syndrome	13.8	MUC5AC, TFF1, TFF2
7	hymenolepiasis	13.7	IFNA1, KRT4, KRT3
8	cystic lymphangioma	13.7	RAPSN, CHRND, TGFB1, CHRNB1, CHRNG
9	attenuated familial adenomatous polyposis	13.6	APEX1, PTGS2, OGG1
10	lymphangioma	13.6	CHRND, TGFB1, PECAM1, CHRNB1, CHRNG
11	inverted papilloma	13.6	PCNA, MKI67, KRT13
12	orofacial cleft	13.5	XRCC1, IRF6, GSTM1, APEX1, ERCC2, CYP1A1
13	atrophic gastritis	13.5	IL1RN, TFF1, TFF2, SOD1
14	hereditary mucosal leukokeratosis	13.4	PCNA, MKI67, GSTM1
15	breast fibroadenoma	13.4	PCNA, MKI67, THBS1, TFF1
16	nonencapsulated sclerosing carcinoma	13.4	S100A6, MKI67, ERBB3, NTRK1, PLAUR, THBS1
17	middle ear cholesteatoma	13.4	PCNA, FGF2, IL1A, ICAM1, KRT13
18	corneal ulcer	13.4	MUC5AC, MMP2, IL1B
19	thrombasthenia	13.4	VWF, F3, THBS1, PECAM1
20	benign tumors	13.4	PCNA, MKI67, PLAUR, SKP2, KRT13, TFF1
21	colonic neoplasm	13.4	CLU, ICAM1, TP53, HBEGF
22	nephrogenic systemic fibrosis	13.3	CTGF, TIMP1, TGFB1, TGM2
23	intestinal neoplasm	13.3	BMP6, MMP2, PTGS2
24	nephrosclerosis	13.3	F3, CTGF, THBS1, TGFB1
25	cardia cancer	13.3	XRCC1, GSTM1, TP53, CYP1A1
26	ocular melanoma	13.3	VEGFA, BMP6, S100A11, S100A6
27	essential thrombocythemia	13.3	KITLG, VWF, IFNA1, G6PD
28	ovarian germ cell tumor	13.3	PCNA, BIRC5, TP53
29	senile cataract	13.3	GSTM1, FGF2, G6PD, SOD1
30	somatoform disorder	13.3	IL1A, IL1B, IL1RN
31	glanzmann's thrombasthenia	13.3	VWF, F3, THBS1, PECAM1
32	endemic goiter	13.3	BMP6, FGF2, IGFBP3, TFF3, SOD1
33	porphyria cutanea tarda	13.3	BMP6, GSTM1, IFNA1, CYP1A1
34	non-hodgkin lymphoma	13.3	KITLG, BIRC5, GSTM1, ERCC2, CYP1A1, SKP2
35	gastric adenocarcinoma	13.3	BIRC5, GSTM1, IL1RN, PTGS2, TIMP3, TFF1
36	nevoid basal cell carcinoma syndrome	13.2	PCNA, XPA, GSTM1, TP53
37	relapsing-remitting multiple sclerosis	13.2	IL1RN, IFNA1, ICAM1, TIMP1
38	angiodysplasia	13.2	VWF, VEGFA, F3
39	skin carcinoma	13.2	MMP2, GSTM1, TP53, THBS1
40	microcystic meningioma	13.2	VEGFA, MMP2, TIMP1
41	localized scleroderma	13.2	BMP6, IL8, CTGF, TGFB1
42	corneal neovascularization	13.2	VEGFA, MMP2, FGF2, THBS1
43	mastocytosis	13.2	KITLG, IL1B, IFNA1, F3, TPSAB1
44	basaloid squamous cell carcinoma	13.1	PCNA, BIRC5, MKI67, TP53, KRT4
45	lung giant cell carcinoma	13.1	PCNA, MMP2, IL8, TIMP1
46	mayer-rokitansky-kuster-hauser syndrome	13.1	LDLR, ERCC2, NTRK1, ABCA1, G6PD, TGIF1
47	inclusion body myositis	13.1	CLU, LDLR, APEX1, IFNA1, ICAM1, CAV1
48	ulceration of vulva	13.1	MUC5AC, S100A9, FGF2, MAPK14, PTGS2, HBEGF
49	hereditary pancreatitis	13.1	CLU, MUC5AC, S100A6, TGFB1, TFF1, SOD1
50	multiple sclerosis	13.1	CD24, IL1A, IL1B, IL1RN, ICAM1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pterygium:

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MGI Mouse Phenotypes related to pterygium:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.2	TFF2, SNAI2, DMC1, CAV1, AQP5, XPA
2	respiratory system phenotype	MP:0005388	9.7	CHRNG, RIPK4, ABCA1, TBX22, AQP5, RAPSN
3	other phenotype	MP:0005395	9.6	TGIF1, ABCA1, PTGS2, CAV1, LDLR, CLU
4	embryogenesis phenotype	MP:0005380	9.6	CHRNG, G6PD, EGFR, SNAI2, ERBB3, XRCC1
5	renal/urinary system phenotype	MP:0005367	9.4	TGM2, THBS1, ABCA1, EGFR, SKP2, CAV1
6	hematopoietic system phenotype	MP:0005397	9.2	RIPK4, TGM2, SKP2, SNAI2, NTRK1, FGF2
7	craniofacial phenotype	MP:0005382	9.2	RIPK4, TGIF1, SNAI2, TBX22, MAPK8, IRF6
8	pigmentation phenotype	MP:0001186	9.1	SNAI2, KRT4, EGFR, TIMP3, CHRNG, NTRK1
9	normal phenotype	MP:0002873	8.9	CYP1A1, CTGF, NTRK1, ACSM3, HBEGF, TGIF1
10	liver/biliary system phenotype	MP:0005370	8.6	SOD1, ABCA1, EGFR, TP53, APEX1, IL6
11	behavior/neurological phenotype	MP:0005386	8.2	ERCC2, NTRK1, SNAI2, PLAUR, HBEGF, TIMP3
12	limbs/digits/tail phenotype	MP:0005371	8.1	RIPK4, TGIF1, THBS1, EGFR, NTRK1, CTGF
13	integument phenotype	MP:0010771	8.0	NTRK1, SNAI2, KRT4, EGFR, HBEGF, RIPK4
14	nervous system phenotype	MP:0003631	7.6	NTRK1, SNAI2, PLAUR, EGFR, G6PD, HBEGF
15	digestive/alimentary phenotype	MP:0005381	7.4	RIPK4, PECAM1, TFF3, TFF2, TFF1, TGFB1
16	skeleton phenotype	MP:0005390	7.2	PTGS2, TBX22, CTGF, SNAI2, EGFR, HBEGF
17	reproductive system phenotype	MP:0005389	7.2	TNF, PTGS2, DMC1, SKP2, TIMP1, TIMP3
18	adipose tissue phenotype	MP:0005375	7.0	TGFB1, EGFR, PTGS2, TNF, TP53, ERCC2
19	growth/size phenotype	MP:0005378	6.9	KRT4, SKP2, PLAUR, SNAI2, NTRK1, CTGF
20	immune system phenotype	MP:0005387	6.4	SNAI2, NTRK1, TNF, TP53, ERCC2, ERBB3
21	mortality/aging	MP:0010768	5.9	TIMP3, XPA, XRCC1, LDLR, RAPSN, VEGFA
22	vision/eye phenotype	MP:0005391	5.7	TNF, PTGS2, CTGF, NTRK1, SNAI2, KRT4
23	tumorigenesis	MP:0002006	5.5	OGG1, IL1A, FGF2, MMP2, XPA, XRCC6
24	muscle phenotype	MP:0005369	5.0	MMP2, XPA, LDLR, CLU, RAPSN, VEGFA
25	homeostasis/metabolism phenotype	MP:0005376	4.2	CHRNG, PECAM1, SOD1, OGG1, ST3GAL4, TFF3
26	cardiovascular system phenotype	MP:0005385	3.7	CTGF, CYP1A1, PTGS2, TNF, TP53, ERBB3
27	cellular phenotype	MP:0005384	2.8	CTGF, DMC1, TBX22, PTGS2, TNF, TP53

Articles related to pterygium:

(show top 50)    (show all 69)

id	Title	Authors	Year	Affiliating Genes
1	Mutations in RIPK4 cause the autosomal-recessive form of popliteal pterygium syndrome. (22197489)	Kalay E.... Akarsu N.A.	2012	RIPK4
2	Small interfering RNA targeting of S phase kinase-int eracting protein 2 inhibits cell proliferation of pterygium fibroblasts. (21270971)	Su Y.... Cui H.	2011	SKP2
3	Overexpression of urokinase-type plasminogen activato r in pterygia and pterygium fibroblasts. (21224999)	Chao S.C.... Yang S.F.	2011	PLAUR
4	Tissue factor expression in human pterygium. (21245964)	Ando R.... Ishida S.	2011	F3
5	Expression of p53 and flow cytometric analysis of DN A index and S-phase fraction in pterygium]. (20979905)	Sang A.M.... Lu H.	2010	TP53
6	Pterygium and genetic polymorphisms of the DNA repair enzymes XRCC1, XPA, and XPD. (20431719)	Chiang C.C.... Tsai F.J.	2010	ERCC2, OGG1, XPA
7	Two missense mutations of the IRF6 gene in two Japanese families with popliteal pterygium syndrome. (20803643)	Matsuzawa N.... Yoshiura K.	2010	IRF6
8	Glucose-6-phosphate-dehydrogenase deficiency as a ris k factor for pterygium. (20484601)	Peiretti E.... Fossarello M.	2010	G6PD
9	Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6. (19036739)	Little H.J.... Shore P.	2009	IRF6
10	Elevation of human alpha-defensins and S100 calcium-binding proteins A8 and A9 in tear fluid of patients with pterygium. (19168894)	Zhou L.... Tan D.T.	2009	DEFA3
11	Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium. (19247455)	Maxia C.... Sirigu P.	2009	PTGS2, BIRC5
12	Expression analysis of human pterygium shows a predom inance of conjunctival and limbal markers and genes associated with cell migrat ion. (19956562)	Jaworski C.J.... Wistow G.	2009	CLU, ALDH3A1, AQP5
13	Vascular endothelial growth factor gene 460 polymorphism is associated with pterygium formation in female patients. (18434853)	Tsai Y.Y.... Tsai F.J.	2008	VEGFA
14	TP53 gene expression, codon 72 polymorphism and human papillomavirus DNA associated with pterygium. (19065760)	Rodrigues F.W.... Moura K.K.	2008	TP53
15	Evaluation of transforming growth factor and vascular endothelial growth factor polymorphisms in Taiwan Chinese patients with pterygium. (18203080)	Bau D.T.... Tsai F.J.	2008	TGFB1, VEGFA, TGIF1
16	A familial case of popliteal pterygium syndrome. (18617879)	Bertele G.... Carletti V.	2008	IRF6
17	Mutation analysis of CHRNA1, CHRNB1, CHRND, and RAPSN genes in multiple pterygium syndrome/fetal akinesia patients. (18179903)	Vogt J.... Maher E.R.	2008	CHRND, CHRNA1, RAPSN
18	Blood vessel multiply and significance of expression of Cox-2, VEGF in pterygium (17444036)	Yan M.... Wang F.	2007	VEGFA, PTGS2
19	Pterygium and genetic polymorphism of DNA double strand break repair gene Ku70. (17768380)	Tsai Y.Y.... Tsai F.J.	2007	XRCC6
20	Angiogenesis in pterygium: study of microvessel density, vascular endothelial growth factor, and thrombospondin-1. (16823458)	Aspiotis M.... Malamou-Mitsi V.	2007	THBS1, PECAM1
21	Neovascularization and mast cells with tryptase activity increase simultaneously in human pterygium. (17635650)	Ribatti D.... Sirigu P.	2007	TPSAB1
22	Expression of cyclooxygenase-2 in pterygium and effe cts of selective cyclooxygenase-2 inhibitor on human pterygium fibroblasts]. (18201523)	Gao Y.... Peng Y.	2007	PTGS2
23	Modulation of cholesterol homeostasis by antiproliferative drugs in human pterygium fibroblasts. (17652712)	Peiretti E.... Fossarello M.	2007	CAV1, ABCA1
24	Cyclooxygenase 2 expression in pterygium. (17515883)	Chiang C.C.... Tsai Y.Y.	2007	PTGS2
25	Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. (17389479)	Kato N.... Tsubota K.	2007	SNAI2
26	Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome. (16826531)	Morgan N.V.... Maher E.R.	2006	CHRNG
27	Oxidative stress in pterygium: relationship between p53 and 8-hydroxydeoxyguanosine. (17093398)	Perra M.T.... Sirigu P.	2006	TP53
28	UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling. (16723453)	Di Girolamo N.... Coroneo M.T.	2006	EGFR, MAPK8, MAPK14
29	Expression of insulin-like growth factor binding protein-3 in pterygium tissue. (16488932)	Wong Y.W.... Beuerman R.	2006	IGFBP3
30	An association between BPDE-like DNA adduct levels and P53 gene mutation in pterygium. (17213797)	Lai T.J.... Chang J.H.	2006	TP53
31	Oxidative DNA damage in pterygium. (15692461)	Tsai Y.Y.... Chang K.C.	2005	OGG1
32	Genomic, cDNA and embryonic expression analysis of zebrafish IRF6, the gene mutated in the human oral clefting disorders Van der Woude and popliteal pterygium syndromes. (15939375)	Ben J.... Chong S.S.	2005	IRF6
33	Novel and de novo mutations of the IRF6 gene detected in patients with Van der Woude or popliteal pterygium syndrome. (16160700)	Peyrard-Janvid M.... Kere J.	2005	IRF6
34	Trefoil factor family mRNA and protein expression in pterygium. (16142316)	Lafontaine P.O.... Creuzot-Garcher C.	2005	TFF1, TFF2, TFF3
35	Effect of p53 codon 72 polymorphism on p53 protein expression in pterygium. (15670080)	Tsai Y.Y.... Chau P.S.	2005	TP53
36	Genetic polymorphism of hOGG1 and risk of pterygium in Chinese. (14716324)	Kau H.C.... Wei Y.H.	2004	OGG1
37	Six families with van der Woude and/or popliteal pterygium syndrome: all with a mutation in the IRF6 gene. (14757865)	Ghassibe M.... Vikkula M.	2004	IRF6
38	Hyperexpression of low-density lipoprotein receptors and hydroxy-methylglutaryl-coenzyme A-reductase in human pinguecula and primary pterygium. (15505045)	Peiretti E.... Fossarello M.	2004	LDLR
39	Trefoil factor family gene and peptide expression in pterygium (14691392)	Lafontaine P.O.... Creuzot-Garcher C.	2003	TFF1, TFF2, TFF3
40	The abnormal expression of interleukine-1 family in pterygium (12870354)	Wen Z.... Liu Z.	2003	IL1A
41	Gene symbol IRF6. Disease: Van der Woude syndrome and popliteal pterygium. (14640121)	Ghassibe M.... Vikkula M.	2003	IRF6
42	Connective tissue growth factor in pterygium: simultaneous presence with vascular endothelial growth factor - possible contributing factor to conjunctival scarring. (12605268)	Van Setten G.... Schultz G.	2003	CTGF
43	Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. (12219090)	Kondo S.... Murray J.C.	2002	IRF6
44	Angiogenesis in pterygium: morphometric and immunohis tochemical study. (12518239)	Marcovich A.L.... Bar-Dayan Y.	2002	VWF
45	Molecular genetic alterations and viral presence in ophthalmic pterygium. (10851263)	Detorakis E.T.... Spandidos D.A.	2000	TP53
46	Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells. (10711680)	Di Girolamo N.... Wakefield D.	2000	MMP2, TIMP1, TIMP3
47	The abnormal expression of epidermal growth factor receptor family in pterygium (11853633)	Liu Z.... Pflugfelder S.C.	2000	ERBB3
48	The PCNA immunohistochemical study of pterygium (11835845)	Long X.... Chen Y.	1999	PCNA
49	Popliteal pterygium syndrome: a clinical study of three families and report of linkage to the Van der Woude syndrome locus on 1q32. (10593995)	Lees M.M.... Chitty L.	1999	IRF6
50	Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium. (8739304)	Kria L.... Amemiya T.	1996	FGF2, BMP6

Genes related to pterygium according to GeneCards:

(show top 50)    (show all 81)

id	Symbol	Description	Score	GeneCards Section Context
1	CHRNG	cholinergic receptor, nicotinic, gamma (muscle)	11.1	Publications, Summaries
2	CHRND	cholinergic receptor, nicotinic, delta (muscle)	11.1	Publications, Summaries
3	IRF6	interferon regulatory factor 6	11.1	Publications, Summaries
4	CHRNB1	cholinergic receptor, nicotinic, beta 1 (muscle)	11.0	Publications
5	RAPSN	receptor-associated protein of the synapse	11.0	Publications
6	TFF2	trefoil factor 2	11.0	Publications
7	DEFA3	defensin, alpha 3, neutrophil-specific	11.0	Publications
8	TFF3	trefoil factor 3 (intestinal)	11.0	Publications
9	TPSAB1	tryptase alpha/beta 1	11.0	Publications
10	S100A11	S100 calcium binding protein A11	11.0	Publications
11	CD24	CD24 molecule	11.0	Publications
12	ACSM3	acyl-CoA synthetase medium-chain family member 3	11.0
13	KCTD5	potassium channel tetramerisation domain containing 5	11.0	Disorders
14	KRT4	keratin 4	11.0	Publications
15	EFNA1	ephrin-A1	11.0	Publications
16	KRT3	keratin 3	11.0	Publications
17	KRT13	keratin 13	11.0	Publications
18	TBX22	T-box 22	11.0
19	AQP5	aquaporin 5	11.0	Publications
20	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	11.0	Publications
21	ALDH3A1	aldehyde dehydrogenase 3 family, member A1	11.0	Publications
22	SNAI2	snail homolog 2 (Drosophila)	11.0	Publications
23	S100A6	S100 calcium binding protein A6	11.0	Publications
24	TFF1	trefoil factor 1	11.0	Publications
25	XPA	xeroderma pigmentosum, complementation group A	11.0	Publications
26	S100A9	S100 calcium binding protein A9	11.0	Publications
27	ST3GAL4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	11.0	Publications
28	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0	Publications
29	DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	11.0
30	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
31	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
32	OGG1	8-oxoguanine DNA glycosylase	11.0	Publications
33	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
34	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
35	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
36	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	11.0	Publications
37	TGIF1	TGFB-induced factor homeobox 1	11.0	Publications
38	ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	11.0	Publications
39	CLU	clusterin	11.0	Publications
40	CTGF	connective tissue growth factor	11.0	Publications
41	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
42	THBS1	thrombospondin 1	11.0	Publications
43	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0	Publications
44	XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	11.0	Publications
45	ERCC2	excision repair cross-complementing rodent repair deficiency, complementation group 2	11.0	Publications
46	KITLG	KIT ligand	11.0	Publications
47	PLAUR	plasminogen activator, urokinase receptor	11.0	Publications
48	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
49	GSTM1	glutathione S-transferase mu 1	11.0	Publications
50	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications

Pathways related to pterygium according to GeneDecks:

(show top 50)    (show all 116)

id	Pathway	Score	Top Affiliating Genes
1	Glioma Invasiveness36	10.1	PLAUR, KITLG, BMP6, FGF2, TIMP3, TIMP1
2	Breast Cancer Regulation by Stathmin136	9.9	FGF2, TIMP3, EGFR, NTRK1, ERBB3
3	Ras Pathway36	9.6	FGF2, TIMP1, CTGF, ERBB3, TIMP3, EGFR
4	Akt Signaling36	9.5	CCL18, ERBB3, IL6, TNF, CTGF, TIMP3
5	eNOS Signaling36	9.2	NTRK1, BMP6, KITLG, CHRNB1, TGFB1, TIMP1
6	Paxillin Interactions36	9.2	FGF2, MAPK8, CTGF, NTRK1, KITLG, MAPK14
7	Telomerase Components in Cell Signaling36	9.1	CTGF, TIMP1, NTRK1, TIMP3, TP53, FGF2
8	ILK Signaling36	9.1	CTGF, PTGS2, TIMP1, EGFR, SNAI2, MAPK8
9	Endothelin-1 Signaling Pathway36	9.0	BMP6, IL6, CCL18, ERBB3, NTRK1, IL1A
10	DNA Repair Mechanisms36	9.0	PCNA, OGG1, APEX1, XRCC1, XPA, MAPK8
11	JNK Pathway36	8.7	BMP6, KITLG, FGF2, TGFB1, NTRK1, TP53
12	14-3-3 Induced Intracellular Signaling36	8.7	KITLG, FGF2, MAPK8, MAPK14, ERBB3, TNF
13	Pathways in cancer20	8.5	TP53, VEGFA, BIRC5, MMP2, TGFB1, EGFR
14	PPAR Pathway36	8.5	IL6, EGFR, CTGF, KITLG, FGF2, MAPK14
15	Rho Family GTPases36	8.5	ERBB3, TIMP3, CCL18, BMP6, TIMP1, NTRK1
16	Rac1 Pathway36	8.4	BMP6, KITLG, FGF2, IL6, MAPK8, CTGF
17	Malaria20	8.3	PECAM1, IL1B, TGFB1, THBS1, IL6, TNF
18	ERK Signaling36	8.2	CCL18, ERBB3, TIMP1, CTGF, IL6, EGFR
19	MIF Regulation of Innate Immune Cells36	8.2	IL1A, IL1B, IL6, IL8, MAPK8, CCL18
20	Nanog in Mammalian ESC Pluripotency36	8.2	EGFR, TIMP3, TIMP1, NTRK1, CTGF, ERBB3
21	p53 Mediated Apoptosis36	8.1	FGF2, TP53, CTGF, NTRK1, EGFR, TIMP1
22	Immune response IL-1 signaling pathway10	8.1	IL1B, IL6, IL1A, TNF, MAPK8, MAPK14
23	Immune response_IL-1 signaling pathway41	8.1	F3, MAPK14, MAPK8, IL1A, IL8, IL6
24	DHA Signaling36	8.1	TIMP3, BMP6, KITLG, TGFB1, EGFR, NTRK1
25	Rap1 Pathway36	8.0	EGFR, KITLG, BMP6, FGF2, TIMP3, ERBB3
26	Immune response MIF in innate immunity response10	8.0	TP53, IL1B, IL6, MAPK8, PTGS2, MAPK14
27	Mitochondrial Apoptosis36	8.0	KITLG, BMP6, FGF2, IL6, TP53, EGFR
28	Immune response_MIF in innate immunity response41	8.0	TP53, MAPK14, IL8, PTGS2, MAPK8, TNF
29	Intracellular Calcium Signaling36	8.0	CHRNG, CTGF, TGFB1, TIMP3, KITLG, BMP6
30	Molecular Mechanisms of Cancer36	7.9	TP53, CTGF, ERBB3, FGF2, CCL18, MAPK8
31	p70S6K Signaling36	7.9	TIMP1, EGFR, NTRK1, CTGF, MAPK14, MAPK8
32	NFAT in Immune Response36	7.9	BMP6, TIMP3, TIMP1, EGFR, NTRK1, CTGF
33	Renin-Angiotensin Pathway36	7.9	MAPK14, EGFR, MAPK8, IL6, BMP6, FGF2
34	Estrogen Pathway36	7.8	CTGF, IL6, FGF2, BMP6, KITLG, MAPK8
35	GPCR Pathway36	7.8	TIMP1, MAPK8, KITLG, BMP6, FGF2, MAPK14
36	Activation of PKC through GPCR36	7.8	TGM2, TGFB1, FGF2, BMP6, IL6, CTGF
37	GSK3 Signaling36	7.7	KITLG, BMP6, IL6, MAPK14, MAPK8, FGF2
38	Apoptotic Pathways in Synovial Fibroblasts36	7.7	TP53, TNF, CTGF, NTRK1, TIMP1, IL6
39	NF-KappaB (p50-p65) Pathway36	7.7	IL1B, KITLG, BMP6, FGF2, IL1A, IL6
40	NF-KappaB Family Pathway36	7.6	EGFR, TIMP3, TIMP1, TGFB1, CTGF, TNF
41	Cellular Apoptosis Pathway36	7.6	TP53, TGFB1, TIMP3, TIMP1, EGFR, NTRK1
42	Pancreatic Adenocarcinoma36	7.6	KITLG, IL6, FGF2, MMP2, BIRC5, BMP6
43	TGF-Beta Pathway36	7.3	CTGF, EGFR, TIMP1, TIMP3, TGFB1, MAPK14
44	JAK-STAT Pathway36	7.3	IL8, TGFB1, IL1A, FGF2, KITLG, IL6
45	PAK Pathway36	7.0	CTGF, NTRK1, TIMP1, TIMP3, TNF, TGFB1
46	Antioxidant Action of Vitamin-C36	7.0	CCL18, TIMP3, MAPK8, TNF, CTGF, NTRK1
47	Tec Kinases Signaling36	6.9	IL8, IL6, ERBB3, IL1A, FGF2, BMP6
48	MAPK Family Pathway36	6.8	MAPK8, BMP6, FGF2, IL1A, IL1B, IL6
49	MAPK Signaling36	6.7	KITLG, TGFB1, TIMP3, TIMP1, EGFR, NTRK1
50	p38 Signaling36	6.5	KITLG, BMP6, FGF2, IL1A, IL1B, TGFB1

Compounds related to pterygium according to GeneDecks:

(show top 50)    (show all 340)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.4	CTGF, TP53
2	hyaluronic acid32 18	11.3	TFF1, THBS1, PLAUR, FGF2, BMP6
3	egcg32	9.3	SOD1, TIMP1, G6PD, ERBB3, IGFBP3, MAPK14
4	ascorbic acid32 18	10.2	OGG1, TGIF1, G6PD, CYP1A1, IGFBP3, APEX1
5	rapamycin32 42	10.0	MAPK8, LDLR, VEGFA, KITLG, ERBB3, PECAM1
6	n acetylcysteine32	8.7	EGFR, PLAUR, CTGF, TP53, APEX1, MMP2
7	h2o232	8.7	OGG1, TFF3, TFF1, TGIF1, ICAM1, MAPK14
8	heparin32 9 18 9	11.7	CAV1, F3, APEX1, IL1RN, VWF, KITLG
9	cysteine32	8.6	TFF1, THBS1, TIMP3, TIMP1, PLAUR, NTRK1
10	progesterone32 42 9 18 9	12.5	NTRK1, ERBB3, CAV1, S100A6, CLU, BIRC5
11	doxorubicin32 34 9 9	11.3	MKI67, XRCC6, CLU, BMP6, KITLG, MAPK14
12	ribonucleic acid32	8.3	MMP2, MUC5AC, CLU, BMP6, KITLG, IL1A
13	retinoid32	8.2	TFF1, TGM2, TGIF1, TIMP1, HBEGF, EGFR
14	oligonucleotide32	8.2	EFNA1, XPA, XRCC1, MUC5AC, CLU, BIRC5
15	celecoxib32 42 34 9 18 9	13.2	PCNA, VEGFA, BIRC5, EGFR, PTGS2, IGFBP3
16	ns 39832 42	9.2	TGFB1, SKP2, TNF, MAPK14, MAPK8, IL8
17	simvastatin32 34 42 9 18 9	13.1	ABCA1, CTGF, TNF, CAV1, F3, ICAM1
18	cyclosporin a32 42	9.1	PECAM1, TGFB1, THBS1, TIMP1, ABCA1, CAV1
19	oxygen32 18	9.1	PECAM1, MAPK8, APEX1, GSTM1, MUC5AC, CLU
20	cytochalasin d32 42	8.9	THBS1, TIMP1, CTGF, CAV1, ICAM1, MAPK14
21	aspirin32 34 18	9.9	PTGS2, F3, IGFBP3, IL1RN, MMP2, LDLR
22	sb 20358032 42	8.9	FGF2, MMP2, BIRC5, BMP6, VEGFA, THBS1
23	gm-csf32	7.8	KITLG, TGFB1, TNF, ICAM1, IL8, IL6
24	tgf beta132	7.8	PLAUR, CTGF, TNF, IGFBP3, IL6, IL1RN
25	prostacyclin32	7.7	PECAM1, VWF, VEGFA, BMP6, SOD1, THBS1
26	matrigel32	7.6	PECAM1, TGFB1, THBS1, TIMP3, TIMP1, HBEGF
27	estrogen32	7.5	SNAI2, NTRK1, CTGF, ERBB3, IGFBP3, AQP5
28	testosterone32 9 18 9	10.5	ST3GAL4, TFF1, TGIF1, THBS1, TIMP3, HBEGF
29	15-deoxy-delta-12,14-prostaglandin j232	7.5	TNF, MAPK14, MAPK8, IL8, IL6, IL1B
30	creatinine32	7.3	XRCC1, BMP6, PCNA, VWF, KITLG, MMP2
31	methotrexate32 34 42 9 9	11.1	KITLG, TNF, ERCC2, IGFBP3, IL6, IL1RN
32	troglitazone32 42 9 9	9.9	TGFB1, ABCA1, KRT13, SKP2, CYP1A1, PTGS2
33	paclitaxel32 34 9 9	9.7	TGFB1, THBS1, TIMP1, G6PD, EGFR, PCNA
34	nitric oxide32 9 18 9	9.7	BIRC5, BMP6, KITLG, PLAUR, NTRK1, CTGF
35	indomethacin32 9 9	8.6	TFF3, TFF2, TFF1, TGFB1, TIMP1, PLAUR
36	paraffin32	6.6	THBS1, TIMP3, TIMP1, HBEGF, EGFR, KRT13
37	herbimycin a32 42	7.5	TNF, ICAM1, MAPK14, MAPK8, IL8, IL6
38	thymidine32 18	7.4	PECAM1, OGG1, TFF1, TGIF1, TGFB1, THBS1
39	pdtc32	6.2	TGFB1, PTGS2, TNF, TP53, F3, ICAM1
40	cisplatin32 34 9 9	9.2	TGFB1, TIMP1, HBEGF, G6PD, EGFR, PLAUR
41	ly29400232	6.1	MAPK14, MAPK8, IL8, IL6, IL1B, FGF2
42	vegf32	5.7	CYP1A1, PTGS2, TP53, ERCC2, ERBB3, CAV1
43	pd 98,05932	5.5	TFF3, TGFB1, THBS1, TIMP3, TIMP1, HBEGF
44	tyrosine32	5.4	ST3GAL4, TFF3, TGIF1, THBS1, TIMP3, TIMP1
45	curcumin32	5.3	TGFB1, TIMP1, EGFR, PLAUR, CTGF, CYP1A1
46	actinomycin d32	5.2	TP53, KITLG, VEGFA, F3, ICAM1, IFNA1
47	genistein32 9 18 9	8.0	TNF, ERBB3, CAV1, ICAM1, MAPK14, MAPK8
48	dexamethasone32 42 34 9 9	8.3	TFF1, TGIF1, TGFB1, THBS1, TIMP3, TIMP1
49	cycloheximide32	3.2	PECAM1, TFF1, TGFB1, THBS1, TIMP1, HBEGF
50	serine32	3.1	IL8, IL1RN, IL1A, FGF2, MKI67, MMP2

Cellular components related to pterygium according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	9.6	THBS1, TIMP3, TPSAB1, F3, CLU, VWF
2	platelet alpha granule lumen	GO:031093	9.0	TGFB1, THBS1, TIMP1, CLU, VEGFA, VWF
3	cell surface	GO:009986	7.9	NTRK1, PLAUR, HBEGF, TGFB1, TNF, CAV1
4	extracellular region	GO:005576	6.4	PLAUR, HBEGF, TIMP1, THBS1, TGFB1, TFF3
5	extracellular space	GO:005615	5.0	KITLG, ERBB3, TPSAB1, TNF, CTGF, EGFR

Biological processes related to pterygium according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol homeostasis	GO:042632	10.3	ACSM3, ABCA1, CAV1, CD24, LDLR
2	erythrocyte maturation	GO:043249	10.2	TIMP1, G6PD, ERCC2
3	base-excision repair	GO:006284	10.1	OGG1, TP53, APEX1, XRCC1, PCNA
4	response to organic cyclic compound	GO:014070	10.0	IL1RN, ICAM1, ALDH3A1, PTGS2, CTGF, TIMP3
5	nucleotide-excision repair	GO:006289	10.0	OGG1, TP53, ERCC2, XPA, PCNA
6	positive regulation of blood vessel endothelial cell migration	GO:043536	9.9	TGFB1, THBS1, FGF2, VEGFA
7	ovarian follicle development	GO:001541	9.8	SOD1, DMC1, ICAM1, KITLG
8	response to gamma radiation	GO:010332	9.8	IL1A, IL1B, CAV1, TP53
9	response to organic nitrogen	GO:010243	9.8	PTGS2, IL1RN, IL1B, IL1A
10	chronic inflammatory response to antigenic stimulus	GO:002439	9.8	IL1B, IL1RN, TNF
11	positive regulation of fever generation	GO:031622	9.8	PTGS2, TNF, IL1B
12	positive regulation of histone acetylation	GO:035066	9.8	TGFB1, SNAI2, IL1B
13	positive regulation vascular endothelial growth factor production	GO:010575	9.8	TGFB1, PTGS2, IL1B, IL1A
14	response to mechanical stimulus	GO:009612	9.7	F3, CAV1, TNF, TIMP3
15	positive regulation of angiogenesis	GO:045766	9.7	THBS1, NTRK1, F3, IL1B, IL1A, FGF2
16	response to estradiol stimulus	GO:032355	9.6	TFF1, TGFB1, CTGF, PTGS2, F3, IL1B
17	aging	GO:007568	9.6	TGFB1, TIMP3, TIMP1, ERCC2, ALDH3A1, F3
18	positive regulation of cell division	GO:051781	9.6	VEGFA, FGF2, IL1A, IL1B, TGFB1
19	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.6	TFF2, NTRK1, CTGF, TNF, IL1B, IL1A
20	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	KITLG, VEGFA, IL6, TP53, EFNA1
21	platelet degranulation	GO:002576	9.4	PECAM1, SOD1, TGFB1, THBS1, TIMP1, CLU
22	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	TGM2, HBEGF, PTGS2, TNF, IL6
23	positive regulation of cell migration	GO:030335	9.3	TGFB1, THBS1, HBEGF, EGFR, SNAI2, F3
24	cellular response to growth factor stimulus	GO:071363	9.3	TGFB1, NTRK1, MAPK14, TGIF1
25	lipopolysaccharide-mediated signaling pathway	GO:031663	9.3	TGFB1, TNF, MAPK14, IL1B
26	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	EGFR, PTGS2, TNF, ICAM1, IL1B
27	activation of MAPK activity	GO:000187	9.2	EFNA1, FGF2, IL1B, MAPK14, TNF, THBS1
28	positive regulation of protein complex assembly	GO:031334	9.2	TGFB1, TNF, VEGFA
29	positive regulation of protein kinase B signaling cascade	GO:051897	9.1	TGFB1, THBS1, HBEGF, EGFR, TNF, F3
30	positive regulation of MAP kinase activity	GO:043406	9.1	TGFB1, EGFR, TNF, CD24, VEGFA, KITLG
31	positive regulation of interleukin-6 production	GO:032755	9.1	TNF, IL6, IL1B, IL1A
32	positive regulation of protein phosphorylation	GO:001934	9.1	TGFB1, CTGF, TNF, IL1B, VEGFA
33	anti-apoptosis	GO:006916	9.1	SOD1, THBS1, TNF, F3, IL1B, IL1A
34	MAPK cascade	GO:000165	9.0	TGFB1, EGFR, TNF, CAV1, IL1B
35	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.9	TGFB1, TNF, CAV1, IL6, VEGFA
36	positive regulation of apoptotic process	GO:043065	8.9	SOD1, PTGS2, TNF, TP53, IGFBP3, IL1B
37	response to glucocorticoid stimulus	GO:051384	8.9	PTGS2, TNF, CAV1, ALDH3A1, IL6, IL1RN
38	cell proliferation	GO:008283	8.8	EGFR, SKP2, TP53, ERCC2, IL1A, MKI67
39	response to hypoxia	GO:001666	8.8	TGFB1, THBS1, TNF, ERCC2, CAV1, ALDH3A1
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.7	TGFB1, NTRK1, TNF, ICAM1, IL6, IL1B
41	signal transduction	GO:007165	8.6	ERBB3, PLAUR, EGFR, HBEGF, PECAM1, CHRNB1
42	response to drug	GO:042493	8.6	PTGS2, THBS1, TGFB1, TGIF1, SOD1, TNF
43	positive regulation of cell proliferation	GO:008284	8.5	EGFR, TIMP1, TGFB1, TFF2, CTGF, ALDH3A1
44	platelet activation	GO:030168	8.5	PECAM1, SOD1, TGFB1, THBS1, TIMP1, MAPK14
45	blood coagulation	GO:007596	8.3	TIMP1, THBS1, TGFB1, SOD1, PECAM1, PLAUR
46	inflammatory response	GO:006954	8.1	TGFB1, PTGS2, TNF, CCL18, IL8, IL6
47	negative regulation of apoptotic process	GO:043066	7.6	VEGFA, THBS1, TIMP1, EGFR, PLAUR, SNAI2
48	negative regulation of cell proliferation	GO:008285	7.5	TP53, TNF, PTGS2, NTRK1, TGFB1, TGIF1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.4	TGFB1, TNF, TP53, ERCC2, MAPK14, IL6

Molecular functions related to pterygium according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	damaged DNA binding	GO:003684	10.2	XRCC1, XPA, APEX1, OGG1
2	fibronectin binding	GO:001968	9.9	THBS1, CTGF, IGFBP3, VEGFA
3	interleukin-1 receptor binding	GO:005149	9.7	IL1A, IL1B, IL1RN
4	protein homodimerization activity	GO:042803	8.7	PTGS2, NTRK1, G6PD, TGFB1, SOD1, ERBB3
5	enzyme binding	GO:019899	8.4	TGFB1, EGFR, PLAUR, PTGS2, TP53, CAV1
6	growth factor activity	GO:008083	8.4	CTGF, HBEGF, TGFB1, TFF1, IL6, IL1B
7	cytokine activity	GO:005125	8.3	TNF, IL6, IL1B, IL1A, FGF2, BMP6
8	protein binding	GO:005515	2.5	EFNA1, SKP2, PLAUR, NTRK1, DMC1, TNF