MCID: PTR004
MIFTS: 40

Pterygium malady

Summaries for Pterygium

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MalaCards: Pterygium is related to popliteal pterygium syndrome and multiple pterygium syndrome lethal type. An important gene associated with Pterygium is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Presynaptic nicotinic acetylcholine receptors and Calcium channels. The compound galantamine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Pterygium

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8Disease Ontology, 60UMLS, 34MeSH
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Aliases & Descriptions:

pterygium 8 60


External Ids:

Disease Ontology8 DOID:0002116
MeSH34 D011625

Related Diseases for Pterygium

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17GeneCards, 18GeneDecks
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Diseases in the Central Pterygium family:

pterygium Multiple Pterygium Syndrome, Dominant

Diseases related to Pterygium via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1popliteal pterygium syndrome30.7IRF6
2multiple pterygium syndrome lethal type30.6CHRND, CHRNG, CHRNA1
3fetal akinesia deformation sequence29.7RAPSN
4multiple pterygium syndrome escobar type10.6
5pinguecula10.5
6scleritis10.4
7antecubital pterygium10.3
8popliteal pterygium syndrome lethal type10.3
9central pterygium10.3
10double pterygium10.3
11popliteal pterygium syndrome 2, lethal type10.2
12astigmatism10.2
13multiple pterygium syndrome aslan type10.2
14cataract10.2
15multiple pterygium syndrome x-linked10.2
16pterygium of the conjunctiva and cornea10.2
17pterygium colli - intellectual deficit - digital anomalies10.2
18progressive peripheral pterygium10.1
19pterygium of the conjunctiva, familial form10.1
20autosomal dominant multiple pterygium syndrome10.1
21burns10.0
22keratitis10.0
23squamous cell carcinoma10.0
24pterygium colli mental retardation digital anomalies10.0
25spondylohypoplasia, arthrogryposis and popliteal pterygium10.0
26popliteal pterygium syndrome 110.0
27x-linked lethal multiple pterygium syndrome10.0
28cystic lymphangioma10.0CHRNG, CHRND
29congenital myasthenic syndrome10.0CHRNA1, CHRND, CHRNB1, RAPSN
30nicotine dependence10.0CHRNB1
31slow-channel congenital myasthenic syndrome10.0CHRNA1, CHRND, CHRNB1
32myasthenic syndrome, fast-channel congenital10.0CHRNA1, CHRND
33congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNB1, RAPSN
34myasthenia gravis10.0CHRNA1, RAPSN
35stomach cancer10.0EFNA1, TFF2, TFF3
36adenoma10.0TFF3
37breast cancer10.0ALDH3A1, TFF2, TFF3, SNAI2, EFNA1
38keratoconus10.0KRT3
39ocular surface burns10.0
40conjunctiva squamous cell carcinoma10.0
41xeroderma pigmentosum10.0
42nail-patella syndrome10.0
43cleft lip10.0
44cleft palate10.0
45conjunctivochalasis10.0
46achondrogenesis type ib10.0
47endophthalmitis10.0
48esotropia10.0
49leprosy10.0
50turner syndrome10.0

Graphical network of the top 20 diseases related to Pterygium:



Diseases related to pterygium

Clinical Features for Pterygium

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Drugs & Therapeutics for Pterygium

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pterygium

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Anatomical Context for Pterygium

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32MalaCards
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MalaCards organs/tissues related to Pterygium:

32
Eye, Endothelial, Testes, Kidney, Lung, Thyroid, Myeloid

Animal Models for Pterygium or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pterygium:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.3AQP5, RIPK4, TBX22, SNAI2, TFF3, TFF2

Publications for Pterygium

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50PubMed
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Articles related to Pterygium:

(show top 50)    (show all 613)
idTitleAuthorsYear
1
Prediction of mean corneal power change after pterygium excision. (24326329)
2014
2
Antifibrotic Effect of Pirfenidone on Human Pterygium Fibroblasts. (24400786)
2014
3
Ocular demodicosis as a risk factor of pterygium recurrence. (23664471)
2013
4
Association between pterygium and plica semilunaris morphology. (23432762)
2013
5
Observation of long-term efficacy of corneal limbal conjunctival autografts in microscopy treatments of pterygium. (24396959)
2013
6
Topical application of bevacizumab as an adjunct to recurrent pterygium surgery. (23187164)
2013
7
A survey of pterygium surgery in Thailand 2010. (23720980)
2013
8
Effect of pterygium on contrast sensitivity. (23948947)
2013
9
Expression of CREB in primary pterygium and correlation with cyclin D1, ki-67, MMP7, p53, p63, Survivin and Vimentin. (23838680)
2013
10
Increased importin 13 activity is associated with the pathogenesis of pterygium. (23559854)
2013
11
Anesthetic management of a pregnant patient with multiple pterygium syndrome (Escobar type). (22325835)
2012
12
Pterygium surgery by means of conjunctival autograft: long term follow-up. (23258655)
2012
13
Prevalence and associated factors for pterygium and pinguecula in a South Indian population. (22112236)
2012
14
Evaluation of iron, zinc, and copper levels in pterygium tissue. (22350381)
2012
15
Mooren ulcer occurring at donor site after contralateral conjunctivolimbal autograft for recurrent pterygium. (22580428)
2012
16
Relations between lymphangiogenesis and the size of pterygium. (22773979)
2012
17
Childhood pterygium: a descriptive study of 19 cases presented to a tertiary eye care center. (22935599)
2012
18
Application of in vivo laser scanning confocal microscopy for evaluation of ocular surface diseases: lessons learned from pterygium, meibomian gland disease, and chemical burns. (22511027)
2012
19
Traditional eye medication and pterygium occurrence in Limpopo Province. (22831948)
2012
20
Long-term follow-up of pterygium surgery using a conjunctival autograft and Tissucol. (20861727)
2011
21
Treatment of pterygium. (21912002)
2011
22
Acquired melanosis of a conjunctival autograft following pterygium surgery. (21550292)
2011
23
The use of mitomycin C with autologous limbal-conjunctival autograft transplantation for management of recurrent pterygium. (21339805)
2011
24
Subconjunctival bevacizumab immediately after excision of primary pterygium: the first clinical trial. (21955635)
2011
25
Congenital vertical talus in multiple pterygium syndrome. (21654467)
2011
26
Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial. (19498450)
2010
27
Assessment of fibrin glue in pterygium surgery. (19907303)
2010
28
Multiple subconjunctival bevacizumab for advanced primary pterygium. (21138148)
2010
29
Ropivacaine for topical anesthesia in pterygium surgery with fibrin glue for conjunctival autograft. (20164749)
2010
30
CYP1A1 gene polymorphisms as a risk factor for pterygium. (20596254)
2010
31
Atomic force microscope-related study membrane-associated cytotoxicity in human pterygium fibroblasts induced by mitomycin C. (20196562)
2010
32
Endothelial cell loss during pterygium surgery: importance of timing of mitomycin C application. (19654528)
2009
33
Pterygium recurrence after excision with conjunctival autograft: a comparison of fibrin tissue adhesive to absorbable sutures. (19092404)
2009
34
Popliteal Pterygium Syndrome--a case report. (19743799)
2009
35
Effect of pterygium surgery on refractive spherocylinder power and corneal topography. (19205493)
2009
36
Pterygium in an aged Mongolian population: a population-based study in China. (17948037)
2009
37
Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration. (19956562)
2009
38
Pterygium: descriptive nomenclature of the past. (18781256)
2008
39
Blood vessel multiply and significance of expression of Cox-2, VEGF in pterygium]. (17444036)
2007
40
Conjunctival-limbal autograft, amniotic membrane transplantation, and intraoperative mitomycin C for primary pterygium. (18025649)
2007
41
A scleral soft contact lens designed for the postoperative management of pterygium surgery. (17224673)
2007
42
Surgical technique for recurrent pterygium. (16877085)
2006
43
Familial occurrence of multiple pterygium syndrome: expression in a heterozygote of the recessive form or variability of the dominant form? (16964621)
2006
44
Immunologic and clinical manifestations of infectious scleritis after pterygium excision. (17077657)
2006
45
Genomic, cDNA and embryonic expression analysis of zebrafish IRF6, the gene mutated in the human oral clefting disorders Van der Woude and popliteal pterygium syndromes. (15939375)
2005
46
Surgically induced necrotizing scleritis after pterygium excision and conjunctival autograft. (11917181)
2002
47
Multiple pterygium syndrome, bilateral periventricular nodular heterotopia and epileptic seizures--a syndrome? (11748498)
2001
48
A recessively inherited non-lethal form of popliteal pterygium syndrome. (9643601)
1998
49
The popliteal pterygium syndrome: distinct phenotypic variation in two families. (2745146)
1989
50
Phenotypic variation in the popliteal pterygium syndrome. (4203060)
1973

Genetic Variations for Pterygium

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Expression for genes affiliated with Pterygium

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pterygium

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Pathways for genes affiliated with Pterygium

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53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Pterygium

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Pterygium according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1galantamine44 49 1112.4CHRNB1, CHRND, CHRNA1, CHRNG

GO Terms for genes affiliated with Pterygium

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16Gene Ontology
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Cellular components related to Pterygium according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.4RAPSN, CHRNB1, CHRND, CHRNA1, CHRNG
2acetylcholine-gated channel complexGO:00589210.3CHRNB1, CHRND, CHRNA1, CHRNG
3postsynaptic membraneGO:04521110.1CHRNG, CHRNA1, CHRND, CHRNB1, RAPSN

Biological processes related to Pterygium according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1skeletal muscle tissue growthGO:04863010.6CHRND, CHRNA1
2regulation of membrane potentialGO:04239110.6CHRNB1, CHRND, CHRNA1, CHRNG
3musculoskeletal movementGO:05088110.6CHRND, CHRNA1
4muscle contractionGO:00693610.5CHRNG, CHRND, CHRNB1
5synaptic transmission, cholinergicGO:00727110.4RAPSN, CHRNB1
6synaptic transmissionGO:00726810.4RAPSN, CHRND, CHRNA1, CHRNG
7neuromuscular processGO:05090510.3CHRNA1, CHRND
8neuromuscular synaptic transmissionGO:00727410.1CHRNA1, CHRNB1

Molecular functions related to Pterygium according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1channel activityGO:01526710.4CHRNB1, CHRNG
2acetylcholine-activated cation-selective channel activityGO:00488910.4CHRNB1, CHRND, CHRNA1, CHRNG
3acetylcholine bindingGO:04216610.3CHRNA1, CHRND, CHRNB1
4acetylcholine receptor activityGO:01546410.1CHRNB1, CHRNA1, CHRNG

Products for genes affiliated with Pterygium

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Sources for Pterygium

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet