MCID: PTR004
MIFTS: 40

Pterygium malady

Summaries for Pterygium

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32MalaCards
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MalaCards: Pterygium is related to popliteal pterygium syndrome and multiple pterygium syndrome lethal type. An important gene associated with Pterygium is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Presynaptic nicotinic acetylcholine receptors and Calcium channels. The compound galantamine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Pterygium

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8Disease Ontology, 60UMLS, 34MeSH
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Aliases & Descriptions:

pterygium 8 60


External Ids:

Disease Ontology8 DOID:0002116
MeSH34 D011625

Related Diseases for Pterygium

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17GeneCards, 18GeneDecks
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Diseases in the Central Pterygium family:

pterygium Multiple Pterygium Syndrome, Dominant

Diseases related to Pterygium via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1popliteal pterygium syndrome30.7IRF6
2multiple pterygium syndrome lethal type30.6CHRND, CHRNG, CHRNA1
3fetal akinesia deformation sequence29.7RAPSN
4multiple pterygium syndrome escobar type10.6
5pinguecula10.5
6scleritis10.4
7antecubital pterygium10.3
8popliteal pterygium syndrome lethal type10.3
9central pterygium10.3
10double pterygium10.3
11popliteal pterygium syndrome 2, lethal type10.2
12astigmatism10.2
13multiple pterygium syndrome aslan type10.2
14cataract10.2
15multiple pterygium syndrome x-linked10.2
16pterygium of the conjunctiva and cornea10.2
17pterygium colli - intellectual deficit - digital anomalies10.2
18progressive peripheral pterygium10.1
19pterygium of the conjunctiva, familial form10.1
20autosomal dominant multiple pterygium syndrome10.1
21burns10.0
22keratitis10.0
23squamous cell carcinoma10.0
24pterygium colli mental retardation digital anomalies10.0
25spondylohypoplasia, arthrogryposis and popliteal pterygium10.0
26popliteal pterygium syndrome 110.0
27x-linked lethal multiple pterygium syndrome10.0
28cystic lymphangioma10.0CHRNG, CHRND
29congenital myasthenic syndrome10.0CHRNA1, CHRND, CHRNB1, RAPSN
30nicotine dependence10.0CHRNB1
31slow-channel congenital myasthenic syndrome10.0CHRNA1, CHRND, CHRNB1
32myasthenic syndrome, fast-channel congenital10.0CHRNA1, CHRND
33congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNB1, RAPSN
34myasthenia gravis10.0CHRNA1, RAPSN
35stomach cancer10.0EFNA1, TFF2, TFF3
36adenoma10.0TFF3
37breast cancer10.0ALDH3A1, TFF2, TFF3, SNAI2, EFNA1
38keratoconus10.0KRT3
39ocular surface burns10.0
40conjunctiva squamous cell carcinoma10.0
41xeroderma pigmentosum10.0
42nail-patella syndrome10.0
43cleft lip10.0
44cleft palate10.0
45conjunctivochalasis10.0
46achondrogenesis type ib10.0
47endophthalmitis10.0
48esotropia10.0
49leprosy10.0
50turner syndrome10.0

Graphical network of the top 20 diseases related to Pterygium:



Diseases related to pterygium

Clinical Features for Pterygium

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Drugs & Therapeutics for Pterygium

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pterygium

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Anatomical Context for Pterygium

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32MalaCards
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MalaCards organs/tissues related to Pterygium:

32
Eye, Endothelial, Testes, Kidney, Lung, Thyroid, Myeloid

Animal Models for Pterygium or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pterygium:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.3AQP5, RIPK4, TBX22, SNAI2, TFF3, TFF2

Publications for Pterygium

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50PubMed
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Articles related to Pterygium:

(show top 50)    (show all 613)
idTitleAuthorsYear
1
Comparison of wide conjunctival flap and conjunctival autografting techniques in pterygium surgery. (23533701)
2013
2
Immunohistochemical analysis of angiotensin converting enzyme in Sardinian pterygium. (23208948)
2013
3
Astigmatic changes following pterygium removal: comparison of 5 different methods. (23514644)
2013
4
Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon. (23378738)
2013
5
Progress in the pathogenesis of pterygium. (24047084)
2013
6
Autologous cryoprecipitate for attaching conjunctival autografts after pterygium excision. (24014989)
2013
7
miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. (23872359)
2013
8
Sequential pterygium excision with conjunctival autograft in the management of primary double-headed pterygia. (24314415)
2013
9
Anesthetic approach to a patient with multiple pterygium (Escobar) syndrome. (22486906)
2012
10
Topical cyclosporine A administration after pterygium surgery. (21725937)
2012
11
Cataract and pterygium surgery results in Venezuelan patients treated in the MisiA^n Milagro program. (22869248)
2012
12
Efficacy of sutureless and glue free limbal conjunctival autograft for primary pterygium surgery. (22864027)
2012
13
Intraoperative subconjunctival bevacizumab as an adjunctive treatment in primary pterygium: a preliminary report. (22882007)
2012
14
Tear osmolarity and ocular changes in pterygium. (22902494)
2012
15
Relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. (23275896)
2012
16
Preoperative subconjunctival injection of mitomycin C as an adjunctive treatment 24 hours before excision of primary pterygium. (23248555)
2012
17
Comparison of Schirmer's test and tear film breakup time test to detect tear film abnormalities in patients with pterygium. (23866414)
2012
18
Expression of double strand DNA breaks repair genes in pterygium. (21077755)
2011
19
Novel sutureless transplantation for primary pterygium associated with cysts. (22553662)
2011
20
Sodium hyaluronate gel as mitomycin C vehicle to reduce potential endothelial toxicity in pterygium surgery. (21743313)
2011
21
The role of radiotherapy in the treatment of pterygium: a review of the literature including more than 6000 treated lesions. (20674450)
2011
22
Study of alkaline phosphatase activity and DNA content of pterygium tissue showing its degenerative character. (23469571)
2011
23
The prevalence of and risk factors for pterygium in an urban Malay population: the Singapore Malay Eye Study (SiMES). (19965830)
2010
24
Epidemiology of pterygium in aged rural population of Beijing, China. (20819632)
2010
25
Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C. (19420332)
2009
26
p53 expression in pterygium in two climatic regions in Turkey. (19384014)
2009
27
Pterygium and associated ocular surface squamous neoplasia. (19139334)
2009
28
Investigation of human papillomavirus and Epstein-Barr virus DNAs in pterygium tissue. (19253231)
2009
29
Phospholipase D in the human ocular surface and in pterygium. (18580262)
2008
30
Evaluation of transforming growth factor and vascular endothelial growth factor polymorphisms in Taiwan Chinese patients with pterygium. (18203080)
2008
31
Familial multiple pterygium syndrome (MPS) is not associated with CHRNG gene mutation. (17431910)
2007
32
Comparison of conjunctival autograft with amniotic membrane transplantation for pterygium surgery: surgical and cosmetic outcome. (17457187)
2007
33
Treatment of pterygium with conjunctival limbal autograft and mitomycin C--a comparative study. (17822189)
2007
34
Prevalence of and factors associated with pterygium in adult Chinese: the Beijing Eye Study. (18043173)
2007
35
Surgical management of double-head pterygium by using a novel technique: conjunctival rotational autograft combined with conjunctival autograft. (17893533)
2007
36
Pterygium unguis formation in porokeratosis of Mibelli. (17459040)
2007
37
Vascularization is more delayed in amniotic membrane graft than conjunctival autograft after pterygium excision. (17173849)
2007
38
Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome. (16826531)
2006
39
Rapid growth of pterygium after photorefractive keratectomy. (17000410)
2006
40
Increased expression of mucinous glycoprotein KL-6 in human pterygium. (16929070)
2006
41
Novel and de novo mutations of the IRF6 gene detected in patients with Van der Woude or popliteal pterygium syndrome. (16160700)
2005
42
Trefoil factor family mRNA and protein expression in pterygium. (16142316)
2005
43
A case of Mooren's ulcer associated with a pterygium. (16365810)
2005
44
Popliteal pterygium syndrome with unusual features. (15080416)
2004
45
Management of infectious scleritis after pterygium excision. (10632006)
2000
46
Intrascleral dissemination of infectious scleritis following pterygium excision. (9536876)
1998
47
Popliteal pterygium syndrome. (2352260)
1990
48
Popliteal pterygium syndrome: an orthopaedic perspective. (2405020)
1990
49
Popliteal pterygium syndrome. (3372139)
1988
50
Popliteal pterygium syndrome: a phenotypic and genetic analysis. (633318)
1978

Genetic Variations for Pterygium

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Expression for genes affiliated with Pterygium

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pterygium

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Pathways for genes affiliated with Pterygium

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53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Pterygium

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Pterygium according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1galantamine44 49 1112.4CHRNB1, CHRND, CHRNA1, CHRNG

GO Terms for genes affiliated with Pterygium

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16Gene Ontology
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Cellular components related to Pterygium according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.4CHRNG, CHRND, CHRNB1, RAPSN, CHRNA1
2acetylcholine-gated channel complexGO:00589210.3CHRNB1, CHRND, CHRNA1, CHRNG
3postsynaptic membraneGO:04521110.1CHRNA1, CHRND, CHRNB1, RAPSN, CHRNG

Biological processes related to Pterygium according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1skeletal muscle tissue growthGO:04863010.6CHRNA1, CHRND
2regulation of membrane potentialGO:04239110.6CHRNA1, CHRND, CHRNB1, CHRNG
3musculoskeletal movementGO:05088110.6CHRNA1, CHRND
4muscle contractionGO:00693610.5CHRNB1, CHRNG, CHRND
5synaptic transmission, cholinergicGO:00727110.4CHRNB1, RAPSN
6synaptic transmissionGO:00726810.4CHRNG, CHRNA1, CHRND, RAPSN
7neuromuscular processGO:05090510.3CHRND, CHRNA1
8neuromuscular synaptic transmissionGO:00727410.1CHRNA1, CHRNB1

Molecular functions related to Pterygium according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1channel activityGO:01526710.4CHRNG, CHRNB1
2acetylcholine-activated cation-selective channel activityGO:00488910.4CHRNB1, CHRND, CHRNA1, CHRNG
3acetylcholine bindingGO:04216610.3CHRND, CHRNB1, CHRNA1
4acetylcholine receptor activityGO:01546410.1CHRNA1, CHRNG, CHRNB1

Products for genes affiliated with Pterygium

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Sources for Pterygium

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet