MCID: PTR004
MIFTS: 36

Pterygium malady

Summaries for Pterygium

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33MalaCards
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MalaCards: Pterygium is related to popliteal pterygium syndrome and multiple pterygium syndrome lethal type. An important gene associated with Pterygium is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Presynaptic nicotinic acetylcholine receptors and Calcium channels. The compound galantamine have been mentioned in the context of this disorder. Related mouse phenotype digestive/alimentary.

Aliases & Classifications for Pterygium

Sources:
8Disease Ontology, 61UMLS, 35MeSH
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Aliases & Descriptions:

pterygium 8 61


External Ids:

Disease Ontology8 DOID:0002116
MeSH35 D011625

Related Diseases for Pterygium

Sources:
17GeneCards, 18GeneDecks
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Diseases in the central pterygium family:

pterygium multiple pterygium syndrome, dominant

Diseases related to Pterygium via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1popliteal pterygium syndrome31.1IRF6
2multiple pterygium syndrome lethal type30.6CHRND, CHRNG, CHRNA1
3fetal akinesia deformation sequence30.0RAPSN
4multiple pterygium syndrome escobar type10.6
5pinguecula10.5
6antecubital pterygium10.4
7n syndrome10.3
8popliteal pterygium syndrome lethal type10.3
9central pterygium10.3
10double pterygium10.3
11popliteal pterygium syndrome 2, lethal type10.3
12multiple pterygium syndrome aslan type10.2
13astigmatism10.2
14multiple pterygium syndrome x-linked10.2
15pterygium of the conjunctiva and cornea10.2
16popliteal pterygium syndrome 110.2
17pterygium colli - intellectual deficit - digital anomalies10.2
18pterygium of the conjunctiva, familial form10.1
19autosomal dominant multiple pterygium syndrome10.1
20burns10.1
21ocular surface burns10.1
22conjunctiva squamous cell carcinoma10.1
23squamous cell carcinoma10.1
24pterygium colli mental retardation digital anomalies10.1
25spondylohypoplasia, arthrogryposis and popliteal pterygium10.1
26multiple pterygium syndrome, dominant10.1
27x-linked lethal multiple pterygium syndrome10.1
28xeroderma pigmentosum10.0
29nail-patella syndrome10.0
30cleft palate10.0
31conjunctivochalasis10.0
32achondrogenesis type ib10.0
33turner syndrome10.0
34noonan syndrome 110.0
35chrna1-related multiple pterygium syndrome, lethal type10.0
36chrnd-related multiple pterygium syndrome, lethal type10.0
37onychomatricoma10.0
38cystic lymphangioma10.0CHRNG, CHRND
39congenital myasthenic syndrome10.0CHRNA1, CHRND, CHRNB1, RAPSN
40nicotine dependence10.0CHRNB1
41slow-channel congenital myasthenic syndrome10.0CHRNA1, CHRND, CHRNB1
42myasthenic syndrome, fast-channel congenital10.0CHRNA1, CHRND
43congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNB1, RAPSN
44myasthenia gravis10.0CHRNA1, RAPSN
45stomach cancer10.0EFNA1, TFF2, TFF3
46adenoma10.0TFF3
47breast cancer10.0ALDH3A1, TFF2, TFF3, SNAI2, EFNA1
48keratoconus10.0KRT3
49corneal disease9.8
50central retinal artery occlusion9.8

Graphical network of the top 20 diseases related to Pterygium:



Diseases related to pterygium

Clinical Features for Pterygium

Drugs & Therapeutics for Pterygium

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pterygium

Anatomical Context for Pterygium

Animal Models for Pterygium or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Pterygium:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.3AQP5, RIPK4, TBX22, SNAI2, TFF3, TFF2

Publications for Pterygium

Sources:
51PubMed
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Articles related to Pterygium:

(show top 50)    (show all 613)
idTitleAuthorsYear
1
Peroxiredoxin I and II in Human Eyes: Cellular Distribution and Association with Pterygium and DNA Damage. (24152995)
2014
2
Expression of vascular endothelial growth factor C in human pterygium. (22910845)
2013
3
Comparison of autologous in situ blood coagulum versus sutures for conjunctival autografting after pterygium excision. (23733278)
2013
4
Options and adjuvants in surgery for pterygium: a report by the American Academy of Ophthalmology. (23062647)
2013
5
The association between pterygium and conjunctival ultraviolet autofluorescence: the Norfolk Island Eye Study. (22176664)
2013
6
Pterygium inversum unguis: report of an extensive case with good therapeutic response to hydroxypropyl chitosan and review of the literature. (23545920)
2013
7
5-Fluorouracil versus mitomycin C as adjuncts to conjunctival autograft in preventing pterygium recurrence. (22246200)
2012
8
Central retinal artery occlusion following peribulbar anesthesia for pterygium excision. (22605889)
2012
9
Scleral melting secondary to surgical excision of a pterygium augmented with mitomycine C application. (22550782)
2012
10
Early surgical debridement in the management of infectious scleritis after pterygium excision. (22354483)
2012
11
Prevalence of and risk factors for pterygium in rural adult chinese populations of the Bai nationality in Dali: the Yunnan Minority Eye Study. (22956605)
2012
12
The effect of topical 0.05% cyclosporine on recurrence following pterygium surgery. (21760716)
2011
13
Use of adjuvant hyperbaric oxygen therapy to support limbal conjunctival graft in the management of recurrent pterygium. (20847683)
2011
14
Multiple pterygium syndrome: mimicking the findings of Turner syndrome. (22308873)
2011
15
Sutureless amniotic membrane transplantation combined with narrow-strip conjunctival autograft for pterygium. (22146880)
2011
16
Effects of Pterygium on Ocular Aberrations. (20697274)
2010
17
Mycophenolic acid suppresses human pterygium and normal tenon fibroblast proliferation in vitro. (20733018)
2010
18
Rotational conjunctival flap surgery reduces recurrence of pterygium. (21081024)
2010
19
Expression of p53 and flow cytometric analysis of DNA index and S-phase fraction in pterygium]. (20979905)
2010
20
Prevalence of pinguecula and pterygium in patients with thyroid orbitopathy. (20458231)
2010
21
Analysis of pathohistological characteristics of pterygium. (21108613)
2010
22
Efficacy of topical bevacizumab for inhibiting growth of impending recurrent pterygium. (20021250)
2010
23
Topical bevacizumab eyedrops for limbal-conjunctival neovascularization in impending recurrent pterygium. (19092418)
2009
24
Foreign body after pterygium surgery simulating an epibulbar tumor. (19300168)
2009
25
Correlation between NGF/TrkA and microvascular density in human pterygium. (19758420)
2009
26
Multiple pterygium syndrome with horseshoe kidney and polydactyly: a further case. (19282756)
2009
27
Corneal and conjunctival findings after mitomycin C application in pterygium surgery: an in-vivo confocal microscopy study. (18537935)
2009
28
Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium. (19247455)
2009
29
Invasive squamous cell carcinoma of the conjunctiva first misdiagnosed as a pterygium: a clinicopathologic case report. (18463488)
2008
30
Expression of survivin protein in pterygium and relationship with oxidative DNA damage. (18266976)
2008
31
Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft. (16778821)
2008
32
The pathogenesis of pterygium: current concepts and their therapeutic implications. (18264653)
2008
33
Anatomical and immunological changes of the cornea in patients with pterygium. (18568879)
2008
34
A familial case of popliteal pterygium syndrome. (18617879)
2008
35
Cyclooxygenase-2 expression in primary and recurrent pterygium. (18579985)
2008
36
Polyglactin sutures versus nylon sutures for suturing of conjunctival autograft in pterygium surgery. (18081902)
2008
37
Current concepts and techniques in pterygium treatment. (17568207)
2007
38
Modulation of cholesterol homeostasis by antiproliferative drugs in human pterygium fibroblasts. (17652712)
2007
39
Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. (17389479)
2007
40
Scleral melting 16 years after pterygium excision with topical Mitomycin C adjuvant therapy. (16938484)
2006
41
Intraoperative ethanol treatment as an adjuvant therapy of pterygium excision. (23675010)
2006
42
Randomised controlled study of conjunctival autograft versus amniotic membrane graft in pterygium excision. (16837545)
2006
43
An association between BPDE-like DNA adduct levels and P53 gene mutation in pterygium. (17213797)
2006
44
Evaluation of TNF-alpha and IL-1beta polymorphisms in Taiwan Chinese patients with pterygium. (15184943)
2005
45
XY gonadal dysgenesis associated with a multiple pterygium syndrome phenotype. (8986268)
1997
46
Popliteal pterygium syndrome with special consideration of the cleft malformation: case report. (1312355)
1992
47
Autosomal dominant antecubital pterygium: syndromic status substantiated. (3409540)
1988
48
Aspergillus panophthalmitis complicating treatment of pterygium. (3219863)
1988
49
Lethal multiple pterygium syndrome: report of a new case with hydranencephaly. (3789017)
1986
50
An incomplete form of the popliteal pterygium syndrome? (6595011)
1984

Genetic Variations for Pterygium

Expression for genes affiliated with Pterygium

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pterygium

Search GEO for disease gene expression data for Pterygium.

Pathways for genes affiliated with Pterygium

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN
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Compounds for genes affiliated with Pterygium

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Pterygium according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1galantamine45 50 1112.4CHRNB1, CHRND, CHRNA1, CHRNG

GO Terms for genes affiliated with Pterygium

Sources:
16Gene Ontology
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Cellular components related to Pterygium according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.4RAPSN, CHRNB1, CHRND, CHRNA1, CHRNG
2acetylcholine-gated channel complexGO:00589210.3CHRNB1, CHRND, CHRNA1, CHRNG
3postsynaptic membraneGO:04521110.1CHRNG, CHRNA1, CHRND, CHRNB1, RAPSN

Biological processes related to Pterygium according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1skeletal muscle tissue growthGO:04863010.6CHRND, CHRNA1
2regulation of membrane potentialGO:04239110.6CHRNB1, CHRND, CHRNA1, CHRNG
3musculoskeletal movementGO:05088110.6CHRND, CHRNA1
4muscle contractionGO:00693610.5CHRNG, CHRND, CHRNB1
5synaptic transmission, cholinergicGO:00727110.4RAPSN, CHRNB1
6synaptic transmissionGO:00726810.4RAPSN, CHRND, CHRNA1, CHRNG
7neuromuscular processGO:05090510.3CHRNA1, CHRND
8neuromuscular synaptic transmissionGO:00727410.1CHRNA1, CHRNB1

Molecular functions related to Pterygium according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1channel activityGO:01526710.4CHRNB1, CHRNG
2acetylcholine-activated cation-selective channel activityGO:00488910.4CHRNB1, CHRND, CHRNA1, CHRNG
3acetylcholine bindingGO:04216610.3CHRNA1, CHRND, CHRNB1
4acetylcholine receptor activityGO:01546410.1CHRNB1, CHRNA1, CHRNG

Products for genes affiliated with Pterygium

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Sources for Pterygium

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet