Pthirus Pubis Infestation malady

Disease Ontology: A lice infestation that involves parasitic infestation by pubic lice pthirus pubis, which are found in the pubic hair, less commonly in eyebrows, eyelashes, beard, mustache, armpit, perianal area, groin, trunk and scalp. the symptoms include itching in the pubic and groin area. intense itching leads to scratching which can cause sores and secondary bacterial infection of the skin.⁶

MalaCards: Pthirus Pubis Infestation, also known as phthirus/pediculus pubis - pubic lice - crabs (& infestation), is related to x-linked magnesium deficiency with epstein-barr virus infection and neoplasia and leber hereditary optic neuropathy. An important gene associated with Pthirus Pubis Infestation is PIGY (phosphatidylinositol glycan anchor biosynthesis, class Y). The compounds d penicillamine and colcemid have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Descriptions:

pthirus pubis infestation 6 8 phthirus/pediculus pubis - pubic lice - crabs (& infestation) 6 infestation by phthirus pubis (disorder) 6 infestation by phthirus pubis 43 phthiriasis pubis 6

pediculosis pubis 6 pediculus pubis 6 phthirus pubis 6 infestation 43 crabs 6

Diseases related to pthirus pubis infestation by text searches and GeneDecks gene sharing:

(show all 47)

id	Related Disease	Score	Top Affiliating Genes
1	x-linked magnesium deficiency with epstein-barr virus infection and neoplasia	12.5	CAT, DNAH8
2	leber hereditary optic neuropathy	12.5	CAT, NPS, MT-CO1
3	familial restrictive cardiomyopathy	12.5	TPM1, DNAH8
4	skin disease	12.2	NPS, CAT, CCR10, DNAH8
5	encephalomyopathy	12.1	DNAH8, CAT, MT-CO1
6	mitochondrial encephalomyopathy	12.0	NPS, MT-CO1, CAT, DNAH8
7	dementia	11.4	NPS, DNAH8, HSPG2, PPT1, CAT
8	dmd-associated dilated cardiomyopathy	11.3	CTNNA2, MT-CO1, CAT, TPM1, DNAH8
9	myopathy	10.7	HSPG2, MT-CO1, CAT, TPM1, DNAH8
10	pediculus humanus capitis infestation	8.0
11	pediculus humanus corporis infestation	7.7
12	parasitic eyelid infestation	7.5
13	scabies	7.5
14	leech infestation	7.3
15	mite infestation	7.3
16	myiasis	7.3
17	tick infestation	7.3
18	demodicidosis	6.1
19	morgellons	6.1
20	ophthalmomyiasis	6.1
21	screw worm infectious disease	6.1
22	tungiasis	6.1
23	late yaws	5.5
24	paragonimiasis	5.5
25	spondylospinal thoracic dysostosis	5.5
26	adenocarcinoma	5.5
27	clonorchiasis	5.5
28	carcinoma	5.5
29	disseminated intravascular coagulation	5.5
30	food allergy	5.5
31	lice infestation	5.5
32	lung adenocarcinoma	5.5
33	asthma	5.2
34	duodenitis	5.2
35	dracunculiasis	5.2
36	endemic typhus	5.2
37	enterobiasis	5.2
38	giardiasis	5.2
39	hymenolepiasis	5.2
40	hypodermyiasis	5.2
41	la crosse encephalitis	5.2
42	norwegian scabies	5.2
43	parasitic ectoparasitic infectious disease	5.2
44	parasitic helminthiasis infectious disease	5.2
45	tick paralysis	5.2
46	thelaziasis	5.2
47	trombiculiasis	5.2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pthirus pubis infestation:

²²

Genes related to pthirus pubis infestation according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	PIGY	phosphatidylinositol glycan anchor biosynthesis, class Y	11.0	Disorders
2	SELM	selenoprotein M	11.0	Disorders
3	AMIGO1	adhesion molecule with Ig-like domain 1	11.0
4	C6orf15	chromosome 6 open reading frame 15	11.0
5	TRIM11	tripartite motif containing 11	11.0	Disorders
6	NPS	neuropeptide S	11.0
7	MEPCE	methylphosphate capping enzyme	11.0
8	CCR10	chemokine (C-C motif) receptor 10	11.0
9	DTX2	deltex homolog 2 (Drosophila)	11.0
10	CCNK	cyclin K	11.0	Disorders
11	ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	11.0	Disorders
12	PPT1	palmitoyl-protein thioesterase 1	11.0
13	CYP4V2	cytochrome P450, family 4, subfamily V, polypeptide 2	11.0
14	ILF2	interleukin enhancer binding factor 2, 45kDa	11.0	Disorders
15	TPM1	tropomyosin 1 (alpha)	11.0
16	CAT	catalase	11.0
17	TMEM132D	transmembrane protein 132D	11.0	Disorders
18	HSPG2	heparan sulfate proteoglycan 2	11.0
19	CTNNA2	catenin (cadherin-associated protein), alpha 2	11.0
20	DNAH8	dynein, axonemal, heavy chain 8	11.0
21	MT-CO1	mitochondrially encoded cytochrome c oxidase I	11.0

Compounds related to pthirus pubis infestation according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	d penicillamine32	9.5	HSPG2, CAT
2	colcemid32	9.2	HSPG2, DNAH8
3	benzyl alcohol32	9.2	CAT, DNAH8
4	cyclopiazonic acid32 42	10.2	HSPG2, DNAH8
5	sodium azide32	8.9	CAT, DNAH8
6	n-ethylmaleimide32 9 9	10.6	DNAH8, CAT, HSPG2