MCID: PTS002
MIFTS: 51

Ptosis malady

Categories: Eye diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Ptosis

Aliases & Descriptions for Ptosis:

Name: Ptosis 12 29 14 69
Blepharoptosis 12 52 42
Drooping Eyelid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060260
ICD9CM 35 374.3 374.30
MeSH 42 D001763
NCIt 47 C27298
UMLS 69 C0005745

Summaries for Ptosis

Disease Ontology : 12 An eye disease characterized by the drooping or falling of the upper or lower eyelid.

MalaCards based summary : Ptosis, also known as blepharoptosis, is related to alopecia areata and blepharophimosis, epicanthus inversus, and ptosis, type 1. An important gene associated with Ptosis is FOXL2 (Forkhead Box L2). The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and breast, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 71 Ptosis (from the Greek word πτῶσις \"falling\", \"a fall\", \"dropped\") refers to droopiness of... more...

Related Diseases for Ptosis

Diseases in the Ptosis family:

Ptosis, Congenital Ptosis, Hereditary Congenital 2
Hereditary Congenital Ptosis

Diseases related to Ptosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
id Related Disease Score Top Affiliating Genes
1 alopecia areata 28.9 CHN1 KIF21A PHOX2A TUBB3
2 blepharophimosis, epicanthus inversus, and ptosis, type 1 12.2
3 ptosis, congenital 12.2
4 intellectual developmental disorder with dysmorphic facies and ptosis 11.9
5 blepharoptosis, myopia, and ectopia lentis 11.9
6 hereditary congenital ptosis 11.8
7 blepharophimosis with ptosis, syndactyly, and short stature 11.7
8 deafness, conductive, with ptosis and skeletal anomalies 11.7
9 ptosis, strabismus, and ectopic pupils 11.7
10 aniridia - ptosis - intellectual disability - familial obesity 11.7
11 vocal cord paralysis and ptosis 11.7
12 ptosis, hereditary congenital 2 11.7
13 blepharophimosis-epicanthus inversus-ptosis due to copy number variations 11.7
14 disproportionate short stature with ptosis and valvular heart lesions 11.7
15 baraitser-winter syndrome 11.7
16 congenital heart disease ptosis hypodontia craniostosis 11.6
17 sparse hair ptosis mental retardation 11.6
18 arthrogryposis multiple congenita, ophthalmoplegia, ptosis 11.6
19 blepharophimosis-epicanthus inversus-ptosis due to 3q23 rearrangement syndrome 11.6
20 blepharophimosis-epicanthus inversus-ptosis due to a point mutation syndrome 11.6
21 ptosis-upper ocular movement limitation-absence of lacrimal punctum syndrome 11.6
22 ptosis-syndactyly-learning difficulties syndrome 11.6
23 microbrachycephaly ptosis cleft lip 11.6
24 optic atrophy opthalmoplegia ptosis deafness myopia 11.6
25 ptosis coloboma mental retardation 11.6
26 ptosis strabismus diastasis 11.6
27 blepharophimosis 11.6
28 kaufman oculocerebrofacial syndrome 11.5
29 marcus gunn phenomenon 11.4
30 baraitser-winter syndrome 1 11.4
31 richieri-costa/guion-almeida syndrome 11.2
32 oculopharyngeal muscular dystrophy 11.2
33 chronic progressive external ophthalmoplegia 11.1
34 3mc syndrome 11.1
35 bell's palsy 11.1
36 kearns-sayre syndrome 11.0
37 horner's syndrome 11.0
38 myasthenia gravis 10.9
39 ohdo syndrome 10.9
40 congenital fiber-type disproportion 10.9
41 tolosa-hunt syndrome 10.9
42 lymphedema-distichiasis syndrome 10.8
43 fibrosis of extraocular muscles, congenital, 1 10.8
44 arthrogryposis, distal, type 5d 10.8
45 vertebral fusion, posterior lumbosacral, with blepharoptosis 10.8
46 tucker syndrome 10.8
47 jorgenson lenz syndrome 10.8
48 native american myopathy 10.8
49 noonan-like syndrome with loose anagen hair 10.7
50 tukel syndrome 10.7

Graphical network of the top 20 diseases related to Ptosis:



Diseases related to Ptosis

Symptoms & Phenotypes for Ptosis

MGI Mouse Phenotypes related to Ptosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 BRPF1 CHN1 COL25A1 FOXC2 FOXL2 MBD5
2 growth/size/body region MP:0005378 10.14 MBD5 MUSK PAX6 PHOX2A POLG UBE3B
3 mortality/aging MP:0010768 10.1 CHN1 CHRNE COL25A1 FOXC2 FOXL2 MBD5
4 nervous system MP:0003631 9.93 PHOX2A POLG TUBB3 TYMP UBE3B CHN1
5 muscle MP:0005369 9.8 CHN1 CHRNE COL25A1 FOXC2 MUSK PAX6
6 respiratory system MP:0005388 9.5 CHRNE COL25A1 FOXC2 MUSK PAX6 PHOX2A
7 skeleton MP:0005390 9.23 MBD5 MUSK PAX6 POLG TYMP BRPF1

Drugs & Therapeutics for Ptosis

Drugs for Ptosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 183)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Everolimus Approved Phase 4 159351-69-6 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
6
Acetylcholine Approved Phase 4,Phase 1,Phase 2 51-84-3 187
7
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 2180-92-9, 38396-39-3 2474
8
Menthol Approved Phase 4,Phase 1,Phase 2 2216-51-5 16666
9
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
10
Morphine Approved, Investigational Phase 4 57-27-2 5288826
11
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
12
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
13
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
14
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
15
Acetaminophen Approved Phase 4 103-90-2 1983
16
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
17
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
18
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
19
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
20
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
21
Ibuprofen Approved Phase 4 15687-27-1 3672
22
Ketorolac Approved Phase 4,Phase 3 74103-06-3, 66635-83-4 3826
23
Probucol Approved Phase 4 23288-49-5 4912
24 tannic acid Approved, Nutraceutical Phase 4
25 Adrenergic Agents Phase 4,Phase 3
26 Adrenergic Agonists Phase 4
27 Adrenergic alpha-Agonists Phase 4
28 Adrenergic beta-Agonists Phase 4
29 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1
30 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1
31 Anti-Arrhythmia Agents Phase 4
32 Anti-Asthmatic Agents Phase 4
33 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2
34 Bronchodilator Agents Phase 4
35 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
36 Diuretics, Potassium Sparing Phase 4
37 Epinephryl borate Phase 4
38 Mydriatics Phase 4,Early Phase 1
39 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
40 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Racepinephrine Phase 4
42 Respiratory System Agents Phase 4
43 Sodium Channel Blockers Phase 4
44 Vasoconstrictor Agents Phase 4
45 Anti-Bacterial Agents Phase 4
46 Antibiotics, Antitubercular Phase 4
47 Antifungal Agents Phase 4
48 Anti-Infective Agents Phase 4,Phase 2
49
Chromium Phase 4 7440-47-3 27668
50 Immunosuppressive Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 512)
id Name Status NCT ID Phase
1 Saline Injection - Assisted Anesthesia in Eyelid Surgery Unknown status NCT01239498 Phase 4
2 National,Multicentric Randomised Study of the Correction of Genital Prolapse With Fascial Repair or Mesh-Prolift Unknown status NCT00771225 Phase 4
3 Compare Sacrospinous Fixation Versus High Uterosacral Ligament Fixation for Uterus Vaginal Prolapse III/IV Unknown status NCT01347021 Phase 4
4 Surgical Treatment To Greater Anterior Vaginal Prolapse Unknown status NCT00676325 Phase 4
5 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
6 Assessment of Stent Malapposition and Neointimal Coverage on Optical coHerence Tomography at Post-procedure and 3 Months After Platinum Chromium Alloy Of the Element™ Stent Implantation Unknown status NCT01581515 Phase 4
7 Relationship Between Initial Plaque Characteristics and Stent Surface Coverage Patterns Unknown status NCT01024179 Phase 4
8 Vibration-Assisted Anaesthesia Completed NCT00793988 Phase 4
9 Efficacy of Aurosling in Frontalis Sling Suspension Surgery Completed NCT00753831 Phase 4
10 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4
11 Outcomes of Anterior Colporrhaphy Versus Graft Reinforced Anterior Prolapse Repair Completed NCT00535301 Phase 4
12 SIS Graft and Traditional Repair in Vaginal Wall Prolapse Completed NCT00827528 Phase 4
13 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
14 Study of Cytrix Use in Pelvic Floor Prolapse Treatment Completed NCT01244165 Phase 4
15 Efficacy Study of Vaginal Mesh for Prolapse Completed NCT00475540 Phase 4
16 Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse Completed NCT00566917 Phase 4
17 Efficacy Study of Vaginal Mesh for Anterior Prolapse Completed NCT00557882 Phase 4
18 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
19 Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair Completed NCT00153231 Phase 4
20 Brow Lifting With Dysport Completed NCT01401803 Phase 4
21 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed NCT02449915 Phase 4
22 Local Infiltration Analgesia With Ropivacaine in Posterior Vaginal Wall Prolapse:a Randomized, Double-Blind Study Completed NCT00769054 Phase 4
23 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4
24 Dilators for Dyspareunia Prevention Completed NCT01299363 Phase 4
25 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4
26 Brow Enhancement Study Completed NCT01308593 Phase 4
27 Analgetic and Anxiolytic Effect of Preoperative Pregabalin Completed NCT00353704 Phase 4
28 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Completed NCT00810745 Phase 4
29 Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy Completed NCT00934999 Phase 4
30 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4
31 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4
32 A Randomized Controlled Study Comparing Three Single-incision Devices for Female Urinary Stress Incontinence Completed NCT00751088 Phase 4
33 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
34 Psychological Well-being, Recovery and Sexuality After Total and Subtotal Hysterectomy Completed NCT00876057 Phase 4
35 A Comparative Efficacy and Safety Study of Compound Carraghenates Cream With Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids Completed NCT01881282 Phase 4
36 IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair Recruiting NCT02155738 Phase 4
37 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Recruiting NCT02431897 Phase 4
38 Permanent Versus Absorbable Colpopexy Trial Recruiting NCT02277925 Phase 4
39 Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction Recruiting NCT01346436 Phase 4
40 ACell MatriStem Pelvic Floor Matrix Versus Native Tissue Repair, Comparative Study Recruiting NCT02021279 Phase 4
41 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Recruiting NCT01805310 Phase 4
42 Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery Recruiting NCT02727322 Phase 4
43 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Recruiting NCT02216305 Phase 4
44 Electrolyte Profile, Nutritional Status and Ileostomy Formation. Recruiting NCT02036346 Phase 4
45 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Recruiting NCT02812186 Phase 4
46 Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery Active, not recruiting NCT03052816 Phase 4
47 Vaginal Estriol Before and Vaginal Surgery for Prolapse Not yet recruiting NCT02906111 Phase 4
48 Gabapentin for Postop Pain After SSLF Not yet recruiting NCT03123861 Phase 4
49 Vessel Injury in Relation With Strut Thickness Assessed by OCT Not yet recruiting NCT03026465 Phase 4
50 Study of the Elevate Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Terminated NCT02121977 Phase 4

Search NIH Clinical Center for Ptosis

Cochrane evidence based reviews: blepharoptosis

Genetic Tests for Ptosis

Genetic tests related to Ptosis:

id Genetic test Affiliating Genes
1 Ptosis 29

Anatomical Context for Ptosis

MalaCards organs/tissues related to Ptosis:

39
Eye, Testes, Breast, Pituitary, Skin, Bone

Publications for Ptosis

Articles related to Ptosis:

(show top 50) (show all 409)
id Title Authors Year
1
Unilateral Ptosis and Homolateral Hemifacial Weakness in Chronic Progressive External Ophthalmoplegia. ( 28512510 )
2017
2
RE: "Unilateral Ptosis and Homolateral Hemifacial Weakness in Chronic Progressive External Ophthalmoplegia". ( 28533811 )
2017
3
Neuromyelitis optica presenting as acute bilateral ptosis. ( 27888234 )
2017
4
Why the Nipple Is an Unreliable Marker for Measuring Breast Ptosis. ( 27927614 )
2017
5
Comments on "Ptosis: An Underestimated Complication after Autologous Fat Injection into the Upper Eyelid". ( 27986777 )
2017
6
Response to "Comments On 'Ptosis: An Underestimated Complication After Autologous Fat Injection into the Upper Eyelid'". ( 27986778 )
2017
7
Oculomotor Nerve Palsy Presented with Isolated Unilateral Ptosis and Minimal Upgaze Palsy. ( 27928389 )
2016
8
Analysis of FOXL2 detects three novel mutations and an atypical phenotype of blepharophimosis-ptosis-epicanthus inversus syndrome. ( 27283035 )
2016
9
Ice test in the diagnosis of myasthenic ptosis. ( 27841181 )
2016
10
Accuracy of the ice test in the diagnosis of myasthenic ptosis. ( 27841180 )
2016
11
SIX2 haploinsufficiency causes conductive hearing loss with ptosis in humans. ( 27383657 )
2016
12
Orbital dermoid presenting as a case of ptosis with monocular elevation deficiency. ( 26874170 )
2016
13
Effect of Pectoral Electrostimulation on Reduction of Mammary Ptosis After Bariatric Surgery. ( 27926631 )
2016
14
A combined one-stage surgical approach of orbital tumor debulking, lid reconstruction, and ptosis repair in children with orbitotemporal neurofibromatosis. ( 27913089 )
2016
15
Lagophthalmos and Ptosis in Inclusion Body Myositis. ( 26784549 )
2016
16
Surgical Microanatomy of Lower Eyelid Tarsal Ectropion Repair With a Putterman Ptosis Clamp. ( 27429229 )
2016
17
Sudden ocular ptosis. ( 26794089 )
2016
18
A Novel Approach to Submandibular Gland Ptosis: Creation of a Platysma Muscle and Hyoid Bone Cradle. ( 27462572 )
2016
19
How the Mueller Muscle-Conjunctival Resection Ptosis Procedure Was Developed. ( 26953976 )
2016
20
Blepharophimosis Ptosis Epicanthus Inversus Syndrome With Congenital Hypothyroidism and Brachydactyly in a 7-Year-Old Girl. ( 27115209 )
2016
21
Temporalis Muscle Transfer for the Treatment of Lagophthalmos in Patients With Leprosy: Refinement in Surgical Techniques to Prevent Postoperative Ptosis. ( 26674897 )
2016
22
Refractive error characteristics in patients with congenital blepharoptosis before and after ptosis repair surgery. ( 27717339 )
2016
23
The Rainbow Scale for Assessing Breast Ptosis: Validation of Three Different Views. ( 27485092 )
2016
24
Congenital eyelid ptosis, decreased glomerular filtration, and orthostatic hypotension: Questions. ( 27858193 )
2016
25
Levator resection with suspensory ligament of the superior fornix suspension for correction of pediatric congenital ptosis with poor levator function. ( 27518546 )
2016
26
Bilateral Ptosis as the First Presentation of Guillain-Barre Syndrome. ( 27057192 )
2016
27
Ptosis and uremia as a rare feature of uremia. ( 27728481 )
2016
28
Clinical trial comparing autogenous fascia lata sling and Gore-Tex suspension in bilateral congenital ptosis. ( 27022237 )
2016
29
Management of Senile Ptosis with Levator Muscle Resection Using the Putterman Clamp. ( 27482474 )
2016
30
Ptosis. ( 27989382 )
2016
31
Reply Re: "Comparison of Fasanella-Servat and Small-Incision Techniques for Involutional Ptosis Repair". ( 27608159 )
2016
32
The Mechanics of Brow-suspension Ptosis Repair: A Comparative Study of Fox Pentagon and Crawford Triangle Techniques. ( 26808175 )
2016
33
Congenital eyelid ptosis, decreased glomerular filtration, and orthostatic hypotension: Answers. ( 27858196 )
2016
34
Facial weakness and eyelid ptosis: Expanding the clinical heterogeneity of Bethlem myopathy from a novel gene mutation. ( 27421963 )
2016
35
Chronic Progressive External Ophthalmoplegia in the Absence of Ptosis. ( 27111092 )
2016
36
Computation of breast ptosis from 3D surface scans of the female torso. ( 27643463 )
2016
37
Ptosis and paralysis of elevation after sub-tenon anesthesia in the medial canthus. ( 27525612 )
2016
38
Simbu Ptosis: An Outreach Approach to Myogenic Ptosis in Eastern Highlands of Papua New Guinea-Experience and Results From a High-Volume Oculoplastic Surgical Camp. ( 27941470 )
2016
39
The Role of Surgeon Technique in Current Practice Patterns for Combined Ptosis and Dermatochalasis. ( 27015239 )
2016
40
Review on surgical management of ptosis and the use of phenylephrine: a national survey of British Oculoplastic Surgery Society (BOPSS) UK Consultants. ( 27599918 )
2016
41
Maximal levator resection in unilateral congenital ptosis with poor levator function. ( 27601423 )
2016
42
16-year-old Girl with Diplopia and Unilateral Upper Lid Ptosis. ( 27413509 )
2016
43
Re: "Comparison of Fasanella-Servat and Small-Incision Techniques for Involutional Ptosis Repair". ( 27608158 )
2016
44
Frontalis suspension with an expanded polytetrafluoroethylene sheet for congenital ptosis repair. ( 26887686 )
2016
45
Ptosis Shmosis. ( 26921808 )
2016
46
Frontalis Sling for the Treatment of Congenital Ptosis. ( 27110323 )
2016
47
Periorbital and Orbital Aging: Senile Enophthalmos as a Cause of Upper Eyelid Ptosis. ( 27348683 )
2016
48
Unilateral anterior persistent fetal vasculature in a child with blepharophimosis-ptosis-epicanthus inversus syndrome: A surgical challenge. ( 27488160 )
2016
49
Factors Associated with Surgical Outcomes in Congenital Ptosis: A 10-Year Study of 319 Cases. ( 28040525 )
2016
50
The prevalence of ptosis in an Iranian adult population. ( 27579459 )
2016

Variations for Ptosis

Expression for Ptosis

Search GEO for disease gene expression data for Ptosis.

Pathways for Ptosis

GO Terms for Ptosis

Molecular functions related to Ptosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.56 BRPF1 FOXC2 FOXL2 MBD5 PAX6 PHOX2A
2 sequence-specific DNA binding GO:0043565 9.02 FOXC2 FOXL2 PAX6 PHOX2A ZFHX4

Sources for Ptosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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