Ptosis malady

Wikipedia: Ptosis (from the Greek word πτῶσις \"falling, a fall\") refers to droopiness of a body part....⁴⁴ more...

MalaCards: Ptosis is related to blepharophimosis, ptosis, and epicanthus inversus syndrome and congenital fibrosis of the extraocular muscles. An important gene associated with Ptosis is PTOS1 (ptosis, congenital 1 (autosomal dominant)), and among its related pathways are Immune response CD16 signaling in NK cells and Development_VEGF signaling via VEGFR2 - generic cascades. The compounds cytochalasin d and melphalan have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and smooth muscle, and related mouse phenotypes are cellular and homeostasis/metabolism.

ptosis 7 43

Diseases related to ptosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 579)

id	Related Disease	Score	Top Affiliating Genes
1	blepharophimosis, ptosis, and epicanthus inversus syndrome	35.4	PCCB, RBP1, ATR, MRPS22, FOXF2, FOXL2
2	congenital fibrosis of the extraocular muscles	29.1	KIF21A, TUBB3, PHOX2A
3	ophthalmoplegia	28.9	KIF21A, CHRND, MTMR14, LAMB2, TUBB3, PHOX2A
4	myasthenia gravis	27.4	MYF6, BCL2, CHRND, LAMB2, FAS, HSP90AA1
5	hodgkin's lymphoma	26.1	SH2D1A, BIRC2, BIRC3, BCL2, ZAP70, LCK
6	breast cancer	25.9	BCL2, ATR, CASP8, TUBB3, TP53, PTEN
7	muscular dystrophy	25.7	MYF6, PABPN1, BCL2, LAMB2, CDKN1A, HSPA4
8	burkitt's lymphoma	25.4	SH2D1A, BIRC2, BIRC3, BIRC5, PARP1, BCL2
9	hearing loss	24.7	BAX, MAPK8, HSPA4, CASP3, CASP8, GJB1
10	chronic lymphocytic leukemia	24.7	LPL, BIRC2, BIRC3, BIRC5, PAWR, BCL2
11	acute lymphoblastic leukemia	24.3	BIRC2, PAWR, BCL2, ZAP70, XIAP, CDK4
12	t-cell leukemia	24.2	BIRC3, BIRC5, BCL2, ZAP70, LCK, XIAP
13	lung adenocarcinoma	22.0	LPL, BIRC2, BIRC5, PARP1, BCL2, BCL2L11
14	cholangiocarcinoma	21.8	BMF, BIRC5, PAWR, PARP1, BCL2, BCL2L11
15	neuropathy	20.1	SERPINF1, PABPN1, PARP1, MTM1, IL3, FAS
16	influenza	20.0	PABPN1, BAX, GSK3B, IL3, FASLG, FAS
17	non-hodgkin lymphoma	20.0	SH2D1A, BIRC2, BIRC3, BIRC5, BECN1, PARP1
18	squamous cell carcinoma	19.3	RBP1, SERPINF1, BIRC2, BIRC3, BIRC5, PARP1
19	lymphoblastic leukemia	19.3	LPL, BIRC2, BIRC5, PAWR, PARP1, BCL2
20	lymphocytic leukemia	18.2	LPL, BMF, BIRC2, BIRC3, BIRC5, PAWR
21	multiple myeloma	18.2	BIRC2, BIRC3, BIRC5, PARP1, BCL2, BCL2L11
22	myeloma	18.0	BMF, BIRC2, BIRC3, BIRC5, PARP1, BCL2
23	cerebritis	17.7	LPL, ZIC1, ZIC4, PARP1, PAX6, BCL2
24	neuroblastoma	17.6	SERPINF1, BIN1, BIRC5, BECN1, PAWR, PARP1
25	colon cancer	17.6	BIN1, BIRC3, BIRC5, BECN1, PAWR, PARP1
26	ischemia	17.4	SERPINF1, LPL, BECN1, PARP1, PAX6, BCL2
27	hypoxia	16.2	SERPINF1, BMF, BIRC3, BIRC5, BECN1, PARP1
28	leukemia	16.0	SH2D1A, WBP1, RBP1, SERPINF1, LPL, BMF
29	prostatitis	15.5	PCYT1A, RBP1, SERPINF1, LPL, BIN1, BIRC2
30	colorectal cancer	15.4	RBP1, LPL, BIRC2, BIRC3, BIRC5, BECN1
31	gastric cancer	15.2	BIRC2, BIRC3, BIRC5, ZIC1, PARP1, BCL2
32	adenocarcinoma	14.8	PCCB, RBP1, SERPINF1, LPL, BIRC2, BIRC3
33	carcinoma	14.5	KIF21A, PCYT1A, RBP1, SERPINF1, LPL, BMF
34	hepatocellular carcinoma	14.1	RBP1, SERPINF1, BMF, BIRC5, BECN1, PARP1
35	slow-channel congenital myasthenic syndrome	14.0	CHRND, CHRNB1, CHRNE
36	multiple pterygium syndrome escobar type	14.0	CHRND, CHRNB1, CHRNG
37	myasthenic syndrome	14.0	CHRND, LAMB2, ACHE, CHRNB1, CHRNE
38	muscle disorders	13.9	MYF6, BIN1, MTMR14, MTM1, DNM2
39	myopathy congenital	13.9	MYF6, BIN1, MTMR14, MTM1, DNM2
40	lymphangioma	13.8	SERPINF1, CHRND, CHRNB1, CHRNG
41	centronuclear myopathy	13.8	MYF6, BIN1, MTMR14, MTM1, CDKN3, ACP1
42	fibrosis of extraocular muscles	13.8	KIF21A, TUBB3, PHOX2A
43	nicotine dependence	13.7	CHRND, PTEN, DDC, CHRNB1, CHRNE, CHRNG
44	caspase-8 deficiency	13.7	FAS, CASP8, TNFSF10
45	autoimmune lymphoproliferative syndrome	13.6	FASLG, FADD, FAS, CASP8, TNFSF10
46	status epilepticus	13.6	BAX, CASP3, TUBB3, ABCC1, ACHE, POLG
47	thoracic cancer	13.6	CDKN1A, CASP3, CASP8, TNFSF10
48	intestinal pseudo-obstruction	13.6	FAS, ACHE, TYMP, POLG
49	congenital myasthenic syndrome	13.6	MYF6, BCL2, CHRND, LAMB2, FAS, HSP90AA1
50	lymphopenia	13.6	ZAP70, LCK, FASLG, FAS, ANXA5, ACHE

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to ptosis:

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MGI Mouse Phenotypes related to ptosis:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	INF	SH2D1A, BMF, BIN1, BIRC2, BIRC3, BIRC5
2	homeostasis/metabolism phenotype	MP:0005376	INF	BECN1, BCL2, BCL2L11, BAK1, BAX, MTMR14
3	mortality/aging	MP:0010768	INF	FOXC2, NR1H4, NOS2, NOS3, PHOX2A, NFE2L2
4	cardiovascular system phenotype	MP:0005385	INF	FAS, MAPK8, MAPK14, MAPK1, CBL, HSPA5
5	no phenotypic analysis	MP:0003012	INF	SYK, ATF6, MTM1, , PARP1, BMF
6	behavior/neurological phenotype	MP:0005386	INF	FOXF2, , GSK3B, FAS, MAPK8, MAPK1
7	vision/eye phenotype	MP:0005391	INF	CASP7, CASP3, GJB1, AIFM1, TP53, PTEN
8	liver/biliary system phenotype	MP:0005370	INF	RBP1, LPL, MTM1, ATF6, ATR, FOXC2
9	growth/size phenotype	MP:0005378	INF	FOXL2, NFE2L2, SHOC2, ACHE, , ACP1
10	embryogenesis phenotype	MP:0005380	INF	PCYT1A, LCK, PAX6, PARP1, BIRC5, MYF6
11	adipose tissue phenotype	MP:0005375	INF	OPA1, SOD2, POLG, RRM2B, E2F1, PTEN
12	nervous system phenotype	MP:0003631	INF	RBP1, SERPINF1, , , BECN1, PARP1
13	digestive/alimentary phenotype	MP:0005381	INF	CTNNB1, CAV1, CASP3, MAP3K14, RRM2B, MAPK8
14	endocrine/exocrine gland phenotype	MP:0005379	10.4	RRM2B, OPA1, CAV1, FOXL2, FASLG, CASP8
15	normal phenotype	MP:0002873	8.9	MYF6, BMF, BIRC2, BIRC3, PAWR, PAX6
16	pigmentation phenotype	MP:0001186	8.4	CTNNB1, PRPF8, SOD2, PTEN, CHRNG, SERPINF1
17	immune system phenotype	MP:0005387	8.3	CBL, HSP90AA1, CASP7, CASP8, TP53, DDIT3
18	renal/urinary system phenotype	MP:0005367	7.6	PAX6, BCL2, NFE2L2, CDK4, FOXC2, GSK3B
19	integument phenotype	MP:0010771	6.9	CDKN1A, CDK4, MCL1, FASLG, FAS, ATR
20	skeleton phenotype	MP:0005390	INF	CDKN1A, ATR, MTM1, BAX, , BAK1
21	hematopoietic system phenotype	MP:0005397	INF	SH2D1A, RBP1, NFE2L2, PSME3, SOD2, CSF3
22	tumorigenesis	MP:0002006	INF	PTEN, CTNNB1, TNFSF10, PLA2G2A, NOS2, NFE2L2
23	hearing/vestibular/ear phenotype	MP:0005377	INF	CBL, CASP3, CTNNB1, ACHE, E2F1, POLG
24	craniofacial phenotype	MP:0005382	INF	FOXF2, FOXC2, ATR, PAX6, , GSK3B
25	respiratory system phenotype	MP:0005388	INF	ACHE, CHRNG, SHOC2, PHOX2A, CBL, PCYT1A
26	reproductive system phenotype	MP:0005389	INF	PCYT1A, RBP1, POLG, E2F1, SOD2, OPA1
27	muscle phenotype	MP:0005369	INF	BIRC3, , PAX6, BCL2, BAX, MTMR14

Articles related to ptosis:

(show top 50)    (show all 118)

id	Title	Authors	Year	Affiliating Genes
1	Cellular inhibitor of apoptosis 1 (cIAP-1) degradatio n by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apo ptosis. (20951133)	Guicciardi M.E.... Gores G.J.	2011	CASP8, BIRC2
2	Regulator of G protein signaling 6 (RGS6) induces apo ptosis via a mitochondrial-dependent pathway not involving its GTPase-activatin g protein activity. (21041304)	Maity B.... Fisher R.A.	2011	RGS6
3	Caspase-14 is an anti-apoptotic protein targeting apo ptosis-inducing factor in lung adenocarcinomas. (21567094)	Fang H.Y.... Ko W.J.	2011	CASP14
4	Mutation spectrum of fork-head transcriptional factor gene (FOXL2) in Indian Blepharophimosis Ptosis Epicanthus Inversus Syndrome (B PES) patients. (21325395)	Kaur I.... Honavar S.G.	2011	FOXL2
5	FOXL2 mutations in Tunisian patients with blepharophi mosis-ptosis-epicanthus inversus syndrome. (20236120)	Kraoua L.... M'rad R.	2010	FOXL2
6	A new FOXL2 gene mutation in a woman with premature o varian failure and sporadic blepharophimosis-ptosis-epicanthus inversus syndrom e. (19969293)	CorrA-a F.J.... AbrALo M.S.	2010	FOXL2
7	Recruitment of PKC-betaII to lipid rafts mediates apo ptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70. (19907441)	zum BA1schenfelde C.M.... Ringshausen I.	2010	ZAP70, PRKCB
8	The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apo ptosis. (20361939)	Wang X.... Ma Z.	2010	TP53
9	Dual role of heat shock proteins as regulators of apo ptosis and innate immunity. (20375559)	Joly A.L.... Garrido C.	2010	HSP90AA1, HSPA4
10	Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apo ptosis suppression of neoplastic cells. (19588508)	Mandal C.... Mandal C.	2010	NEU3
11	Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apo ptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. (20356846)	Feltham R.... Silke J.	2010	BIRC2, BIRC3, MAP3K14
12	The adaptor protein TRIP6 antagonizes Fas-induced apo ptosis but promotes its effect on cell migration. (20876301)	Lai Y.J.... Lin F.T.	2010	FAS, TRIP6
13	Galectin-2 suppresses contact allergy by inducing apo ptosis in activated CD8+ T cells. (19380789)	Loser K.... Beissert S.	2009	LGALS2
14	O-glycan inhibitors generate aryl-glycans, induce apo ptosis and lead to growth inhibition in colorectal cancer cell lines. (19122213)	Patsos G.... Corfield A.	2009	GTDC2
15	MS-275, a histone deacetylase inhibitor, induces apo ptosis and alters survivin gene expression in human myeloma cell line U266 (19624872)	Ma J.... Wang Z.H.	2009	CDK4, CDKN1A, BIRC5
16	MiR-125b expression affects the proliferation and apo ptosis of human glioma cells by targeting Bmf. (19471102)	Xia H.F.... Ma X.	2009	BMF, MIR125B2, MIR125B1
17	Phosphorylation of histone H3 Thr-45 is linked to apo ptosis. (19363025)	Hurd P.J.... Kouzarides T.	2009	HIST2H3C
18	Xanthorrhizol, a natural sesquiterpenoid, induces apo ptosis and growth arrest in HCT116 human colon cancer cells. (19926935)	Kang Y.J.... Lee S.K.	2009	NOS2
19	Inhibiting JNK dephosphorylation and induction of apo ptosis by novel anticancer agent NSC-741909 in cancer cells. (19414586)	Wei X.... Fang B.	2009	MAPK8
20	Potential mechanisms involved in ceramide-induced apo ptosis in human colon cancer HT29 cells. (19462692)	Wang J.... Du Y.G.	2009	MAPK14, PARP1
21	Kauren-19-oic acid induces DNA damage followed by apo ptosis in human leukemia cells. (19391104)	Cavalcanti B.C.... Costa-Lotufo L.V.	2009	TOP1
22	Effect of emodin on proliferation inhibition and apo ptosis induction in leukemic k562 cells (20030921)	Zheng Z.H.... Lin M.H.	2009	CASP3
23	beta-Elemene, a novel plant-derived antineoplastic ag ent, increases cisplatin chemosensitivity of lung tumor cells by triggering apo ptosis. (19513519)	Li Q.Q.... Reed E.	2009	CASP3, ANXA5
24	Differential gene expression of the inhibitor of apo ptosis proteins in docetaxel-resistant gastric cancer cells (19102932)	Wang T.T.... Liu B.R.	2008	BIRC5, XIAP
25	Blepharophimosis-ptosis-epicanthus inversus syndrome in a girl with chromosome translocation t(2;3)(q33;q23). (18363172)	Tzschach A.... Demuth S.	2008	FOXL2
26	Unsaturated fatty acids liberated from VLDL cause apo ptosis in endothelial cells. (18435438)	Reinbold M.... Krieglstein J.	2008	LPL
27	Saxifragifolin B from Androsace umbellata induced apo ptosis on human hepatoma cells. (17765201)	Zhang D.M.... Fung K.P.	2007	PARP1
28	The mutation study of the FOXL2 gene in a big Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome (17393695)	Tang S.J.... Sun Y.	2007	FOXL2
29	Bax activation and mitochondrial insertion during apo ptosis. (17453158)	Lalier L.... Vallette F.M.	2007	BCL2, BAX, BAK1
30	Three novel FOXL2 gene mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome. (16454982)	Or S.F.... Lam T.S.	2006	FOXL2
31	Curcumin sensitizes tumor necrosis factor-related apo ptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation. (16613838)	Jung E.M.... Kwon T.K.	2006	TNFSF10, DDIT3
32	Premature ovarian failure and forkhead transcription factor FOXL2: blepharophimosis-ptosis-epicanthus inversus syndrome and ovarian dysfunction. (16208278)	De Baere E.... Fellous M.	2005	FOXL2
33	A new heterozygous mutation of the FOXL2 gene is associated with a large ovarian cyst and ovarian dysfunction in an adolescent girl with blepharophimosis/ptosis/epicanthus inversus syndrome. (16131596)	Raile K.... Pfaffle R.	2005	FOXL2
34	Dominant optic atrophy, sensorineural hearing loss, ptosis, and ophthalmoplegia: a syndrome caused by a missense mutation in OPA1. (15531309)	Payne M.... Zhang K.	2004	OPA1
35	A novel insertion mutation in the FOXL2 gene is detected in a big Chinese family with blepharophimosis-ptosis-epicanthus inversus. (15450400)	Qian X.... He L.	2004	FOXL2, FOXF2
36	FOXL2-mutations in blepharophimosis-ptosis-epicanthus inversus syndrome (BPES); challenges for genetic counseling in female patients. (12567411)	Fokstuen S.... Blouin J.L.	2003	FOXL2, FOXF2
37	Mutational analysis of forkhead transcriptional factor 2 (FOXL2) in Korean patients with blepharophimosis-ptosis-epicanthus inversus syndrome. (14986827)	Cha S.C.... Kim J.R.	2003	FOXL2
38	Differential effects of interleukin-2 blockade on apo ptosis in naA^ve and activated human lymphocytes. (12777847)	Woodside K.J.... Daller J.A.	2003	FAS
39	Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development. (12810580)	Loffler K.A.... Koopman P.	2003	FOXL2
40	Sporadic and familial blepharophimosis -ptosis-epicanthus inversus syndrome: FOXL2 mutation screen and MRI study of the superior levator eyelid muscle. (12630957)	Dollfus H.... Perrin-Schmitt F.	2003	FOXL2
41	Congenital muscular dystrophy with adducted thumbs, ptosis, external ophthalmoplegia, mental retardation and cerebellar hypoplasia: a novel form of CMD. (12207929)	Voit T.... Herrmann R.	2002	LAMB2
42	Mitochondrial targeting drug lonidamine triggered apo ptosis in doxorubicin-resistant HepG2 cells. (12383880)	Li Y.C.... Kong S.K.	2002	CYCS
43	Heterozygous 17-bp deletion in the forkhead transcription factor gene, FOXL2, in a Japanese family with blepharophimosis-ptosis-epicanthus inversus syndrome. (11776388)	Yamada T.... Endo M.	2001	FOXL2
44	PAX6 mutation in a family with aniridia, congenital ptosis, and mental retardation. (11553050)	Malandrini A.... Renieri A.	2001	PAX6
45	Cellular Retinol Binding Protein 1 (RBP1): a frequent polymorphism, refined map position and exclusion as the Blepharophimosis Ptosis Epicanthus inversus Syndrome gene. (9727204)	Bisceglia L.... Zelante L.	1998	RBP1
46	A noncomitogenic CD2R monoclonal antibody induces apo ptosis of activated T cells by a CD95/CD95-L-dependent pathway. (9574534)	Fournel S.... Revillard J.P.	1998	LCK, FASLG
47	A YAC contig spanning the blepharophimosis-ptosis-epicanthus inversus syndrome and propionic acidemia loci. (9272742)	Piemontese M.R.... Bisceglia L.	1997	PCCB
48	A gene for isolated congenital ptosis maps to a 3-cM region within 1p32-p34.1. (9150162)	Engle E.C.... Beggs A.H.	1997	PTOS1
49	The CD95 (APO-1/Fas) system mediates drug-induced apo ptosis in neuroblastoma cells. (9288794)	Fulda S.... Debatin K.M.	1997	FAS, FASLG
50	Blepharophimosis, Ptosis, and Epi canthus Inversus (20301614)	De Baere E.	1993	FOXL2

Genes related to ptosis according to GeneCards:

(show top 50)    (show all 119)

id	Symbol	Description	Score	GeneCards Section Context
1	PTOS1	ptosis, congenital 1 (autosomal dominant)	11.1	Publications, Aliases & Descriptions
2	SOX14	SRY (sex determining region Y)-box 14	11.0	Summaries
3	PTOS2	Ptosis, hereditary congenital 2	11.0	Publications, Aliases & Descriptions
4	BPESC1	blepharophimosis, epicanthus inversus and ptosis, candidate 1 (non-protein coding)	11.0	Transcripts, Aliases & Descriptions
5	TWIST1	twist homolog 1 (Drosophila)	11.0	Aliases & Descriptions
6	FOXL2	forkhead box L2	11.0	Publications
7	RBP1	retinol binding protein 1, cellular	11.0	Publications
8	ZFHX4	zinc finger homeobox 4	11.0	Publications
9	FOXF2	forkhead box F2	11.0	Publications
10	MRPS22	mitochondrial ribosomal protein S22	11.0	Publications
11	PCCB	propionyl CoA carboxylase, beta polypeptide	11.0	Publications
12	ATR	ataxia telangiectasia and Rad3 related	11.0	Publications
13	ACHE	acetylcholinesterase	11.0
14	MIR330	microRNA 330	11.0	Publications
15	MIR125B2	microRNA 125b-2	11.0	Publications
16	MIR125B1	microRNA 125b-1	11.0	Publications
17	WBP1	WW domain binding protein 1	11.0	Publications
18	CHRNB1	cholinergic receptor, nicotinic, beta 1 (muscle)	10.9
19	LGALS2	lectin, galactoside-binding, soluble, 2	10.9	Publications
20	PHOX2A	paired-like homeobox 2a	10.9
21	CHRNE	cholinergic receptor, nicotinic, epsilon (muscle)	10.9
22	CHRND	cholinergic receptor, nicotinic, delta (muscle)	10.9
23	NEU3	sialidase 3 (membrane sialidase)	10.9	Publications
24	MYF6	myogenic factor 6 (herculin)	10.9
25	CHRNG	cholinergic receptor, nicotinic, gamma (muscle)	10.9
26	TRIP6	thyroid hormone receptor interactor 6	10.9	Publications
27	BMF	Bcl2 modifying factor	10.9	Publications
28	PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	10.9	Publications
29	PCYT1A	phosphate cytidylyltransferase 1, choline, alpha	10.9	Publications
30	MTMR14	myotubularin related protein 14	10.9
31	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	10.9	Publications
32	CASP14	caspase 14, apoptosis-related cysteine peptidase	10.9	Publications
33	LAMB2	laminin, beta 2 (laminin S)	10.9	Publications
34	RRM2B	ribonucleotide reductase M2 B (TP53 inducible)	10.9
35	BECN1	beclin 1, autophagy related	10.9	Publications
36	SH2D1A	SH2 domain containing 1A	10.9	Publications
37	HIST2H3C	histone cluster 2, H3c	10.9	Publications
38	TUBB3	tubulin, beta 3 class III	10.9
39	BIRC2	baculoviral IAP repeat containing 2	10.9	Publications
40	OSR2	odd-skipped related 2 (Drosophila)	10.9	Disorders
41	TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	10.9	Publications
42	PAWR	PRKC, apoptosis, WT1, regulator	10.9	Publications
43	PAX6	paired box 6	10.9	Publications
44	POLG	polymerase (DNA directed), gamma	10.9	Publications
45	SHOC2	soc-2 suppressor of clear homolog (C. elegans)	10.9
46	PABPN1	poly(A) binding protein, nuclear 1	10.9
47	MAP3K14	mitogen-activated protein kinase kinase kinase 14	10.9	Publications
48	NINL	ninein-like	10.9	Publications
49	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	10.9	Publications
50	MTM1	myotubularin 1	10.9

Pathways related to ptosis according to GeneDecks:

(show top 50)    (show all 145)

id	Pathway	Score	Top Affiliating Genes
1	Immune response CD16 signaling in NK cells10	INF	PLA2G2A, LCK, , CBL, ZAP70, MAPK1
2	Development_VEGF signaling via VEGFR2 - generic cascades41	INF	, GSK3B, MAPK1, HSPB1, CTNNB1, NOS2
3	Immune response_CD16 signaling in NK cells41	INF	SYK, LCK, CBL, PLA2G2A, , ZAP70
4	eNOS Signaling36	INF	, , DNM2, CHRNB1, CHRNE, CHRNG
5	Apoptosis through Death Receptors36	INF	TP53, CASP8, CASP3, CASP7, MAP3K14, MAPK8
6	Influenza A20	INF	, PRKCB, CYCS, MAPK1, , TNFRSF10B
7	Focal adhesion20	INF	BIRC2, BIRC3, LAMB2, XIAP, GSK3B, MAPK8
8	Colorectal cancer20	10.5	MAPK8, GSK3B
9	Apoptosis38	10.3	BIRC2, TNFSF10, TNFRSF10B, FASLG, BAX, BAK1
10	Signal transduction_PTEN pathway41	10.3	GSK3B
11	DR3 Signaling36	10.3	CASP8, BIRC2, CYCS, CASP3, CASP7, MAP3K14
12	TWEAK Pathway36	10.2	CASP8, CYCS, CASP3, CASP7, MAP3K14, FADD
13	TRAIL Pathway36	10.1	FADD, CBL, CASP8, TNFRSF10A, TNFRSF10B, CYCS
14	TNFR1 Pathway36	10.1	BIRC2, CASP8, CYCS, CASP3, CASP7, MAP3K14
15	Fas Signaling36	10.1	CASP7, CASP8, CASP3, MAPK8, MAP3K14, CYCS
16	Transcription P53 signaling pathway10	10.0	ATR, TP53, MAPK8
17	Caspase Cascade36	10.0	BIRC2, BIRC3, FADD, CASP7, MAP3K14
18	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins10	9.8	AIFM1, BCL2, CYCS, BAX, CASP8, FAS
19	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins41	9.8	BAK1, BAX, MCL1, FAS, AIFM1, CYCS
20	Apoptosis and survival_Caspase cascade41	9.7	CASP7, CASP3, CASP8, CYCS, PARP1, BAX
21	Apoptosis and survival Caspase cascade10	9.7	PARP1, BAX, XIAP, FASLG, FADD, FAS
22	Apoptosis and survival_TNFR1 signaling pathway41	9.6	BAX, XIAP, FADD, MAPK8, CASP7, CASP3
23	Apoptosis and survival TNFR1 signaling pathway10	9.6	BAX, CASP3, CASP7, MAPK8, FADD, XIAP
24	Apoptosis and survival_Apoptotic TNF-family pathways41	9.6	BCL2, BAX, XIAP, FASLG, FADD, FAS
25	Apoptosis and survival Apoptotic TNF-family pathways10	9.6	TNFSF10, TNFRSF10B, TNFRSF10A, CASP8, BAX, BCL2
26	TNF Superfamily Pathway36	9.4	CASP8, CASP3, CASP7, TNFRSF10B, MAPK14, FADD
27	Apoptotic Pathways Triggered By HIV136	9.2	FADD, MAPK8, MAP3K14, CASP7, CASP3, TP53
28	Small cell lung cancer20	9.1	CDK4, CYCS, BIRC2, TP53, BIRC3, BCL2
29	Signal transduction PTEN pathway10	9.0	CASP3, CBL, MAPK1, GSK3B, PTEN, CDKN1A
30	NOD-like receptor signaling pathway20	9.0	HSP90AA1, BIRC2, BIRC3, XIAP, MAPK8, MAPK14
31	Natural killer cell mediated cytotoxicity20	9.0	MAPK1, SH2D1A, CASP3, LCK, ZAP70, FASLG
32	Endothelin-1 Signaling Pathway36	9.0	CASP3, PLA2G2A, CASP7, MAPK1, TNFSF10, CSF3
33	TNF Signaling36	9.0	BIRC2, BIRC3, MAPK14, CASP7, MAPK1, CASP8
34	Apoptosis and survival FAS signaling cascades10	9.0	FASLG, CASP3, CASP8, FADD, FAS, MAPK8
35	Apoptosis and survival_FAS signaling cascades41	9.0	CASP8, BMF, CYCS, CASP3, BIRC2, PARP1
36	TNF-Induced Apoptosis Implicating Sphingolipids36	8.9	CASP7, CASP3, CYCS, BAX, MAPK1, MAPK14
37	p53 signaling pathway20	8.9	CDKN1A, PTEN, TNFRSF10B, TP53, CASP8, CASP3
38	Apoptosis and Autophagy3	8.9	PAWR, BECN1, BIRC5, BIRC3, BIRC2, BMF
39	Cellular Apoptosis Pathway36	8.9	CASP7, CYCS, BCL2, FADD, BIRC2, PAWR
40	p53 Signaling36	8.7	BCL2, BAX, ATR, CDKN1A, CDK4, MAPK8
41	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	8.7	CYCS, BCL2, MAPK1, BAX, MAPK8, MAPK14
42	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	8.7	MAPK8, BCL2, BAX, MAPK14, MAPK1, CYCS
43	14-3-3 Induced Apoptosis36	8.6	MAP3K14, BCL2, FADD, MAPK14, CASP7, MAPK8
44	p53 Mediated Apoptosis36	8.5	TNFSF10, PTEN, CYCS, TNFRSF10B, TP53, CASP8
45	Transcription_P53 signaling pathway41	8.5	TP53, BCL2, E2F1, CTNNB1, HSPB1, MAPK8
46	Apoptosis20	8.4	MAP3K14, FAS, FADD, FASLG, IL3, XIAP
47	Toxoplasmosis20	8.2	CASP8, CASP3, MAPK1, MAPK14, MAPK8, XIAP
48	Apoptosis Signaling Pathways37	7.8	CASP8, AIFM1, TP53, TNFRSF10A, TNFRSF10B, CASP3
49	Molecular Mechanisms of Cancer36	6.8	CASP8, CASP3, CBL, MAPK1, MAPK8, IL3
50	Pathways in cancer20	6.3	E2F1, PRKCB, NOS2, CTNNB1, CYCS, PTEN

Compounds related to ptosis according to GeneDecks:

(show top 50)    (show all 335)

id	Compound	Score	Top Affiliating Genes
1	cytochalasin d32 42	INF	LPL, LCK, CDKN3, FASLG, MAPK8, MAPK14
2	melphalan32 9 9	12.1	BIRC5, BCL2L11, MCL1, HSPA4, CASP8, TNFSF10
3	h2o232	9.2	BCL2L11, ZAP70, LCK, CDKN3, IL3, ANXA5
4	egcg32	9.2	XIAP, MCL1, MAPK8, MAP3K14, MAPK14, CASP14
5	nitric oxide32 9 18 9	11.9	SERPINF1, BIRC5, BCL2L11, CDK4, FASLG, CASP7
6	irinotecan32 34 9 9	11.6	PARP1, BAK1, BAX, CDKN1A, TUBB3, TP53
7	beta-lapachone32	8.6	PARP1, BCL2, BAX, CDKN1A, FAS, ANXA5
8	n acetylcysteine32	8.5	BIRC5, CDKN1A, CDK4, IL3, MCL1, ANXA5
9	c2ceramide32	8.5	BECN1, PARP1, BAX, MAPK8, MAPK14, HSPB1
10	cyclosporin a32 42	9.5	LPL, CDKN3, CDK4, IL3, FASLG, ANXA5
11	2-chlorodeoxyadenosine32	8.4	BIRC5, PAWR, PARP1, BCL2, BAX, XIAP
12	vitamin e succinate32	8.4	PARP1, BCL2, BAX, CDKN1A, CDKN3, FAS
13	sulindac32 9 9	10.3	BIRC5, BCL2, BAX, XIAP, CDKN1A, CASP8
14	thymidylate32	8.2	BIRC5, BCL2, BAX, CDKN1A, CDK4, MCL1
15	s-nitroso-n-acetylpenicillamine32	8.1	PARP1, ANXA5, MAPK14, HSPA4, CASP3, DDIT3
16	sulforaphane32	8.0	PARP1, CDKN1A, MAPK8, MAPK14, MAPK1, CASP3
17	cysteine32	8.0	SERPINF1, PARP1, LCK, BAK1, XIAP, GTDC2
18	depsipeptide32	8.0	BCL2, BCL2L11, BAX, CDKN1A, IL3, MCL1
19	rottlerin32 42	9.0	PARP1, XIAP, MCL1, MAPK8, MAPK14, MAPK1
20	dutp32	7.9	BIRC5, PARP1, BCL2, BAK1, BAX, XIAP
21	noxa32	7.7	BIRC5, BCL2, BCL2L11, BAK1, BAX, XIAP
22	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	7.7	PARP1, BCL2, BAK1, BAX, FASLG, FAS
23	lipid32	7.7	PCYT1A, RBP1, LPL, BIRC3, BIRC5, BECN1
24	fludarabine32 9 9	9.4	BIRC2, BIRC3, BIRC5, PARP1, BCL2, ZAP70
25	geldanamycin32 9 9	9.4	BIRC5, PARP1, LCK, CDKN1A, CDK4, MAPK14
26	indomethacin32 9 9	9.3	LPL, BIRC5, BAK1, CDKN3, FASLG, FAS
27	docetaxel32 34 9 9	10.2	BIRC2, BIRC5, PARP1, BCL2, BAK1, BAX
28	okadaic acid32 42	8.1	BCL2, LCK, ATR, CDKN3, CDK4, MCL1
29	triptolide32	7.1	BIRC3, PARP1, BCL2, BAX, ANXA5, MAPK8
30	4-hydroxynonenal32 18	8.0	PARP1, BAX, FAS, ANXA5, MAPK8, MAPK14
31	sb 20358032 42	8.0	BIRC2, BIRC3, BIRC5, PARP1, BCL2, BCL2L11
32	celecoxib32 42 34 9 18 9	11.9	BIRC5, PARP1, BCL2, BAK1, BAX, CDKN1A
33	adpribose32	6.7	BIRC5, PARP1, BAK1, BAX, XIAP, CDKN1A
34	camptothecin32 42 9 9	9.5	BIRC5, PARP1, BCL2, BAK1, BAX, XIAP
35	mg 13232 42	7.4	BIRC3, BIRC5, PARP1, BCL2L11, BAX, XIAP
36	imatinib32 34 9 9	9.4	BIRC5, PAWR, PARP1, BCL2, BCL2L11, ZAP70
37	thapsigargin32 42	7.1	BCL2, BAK1, ATF6, CDKN3, ANXA5, MAPK8
38	etoposide32 42 9 9	9.1	BIRC2, BIRC3, BIRC5, PARP1, BCL2, BCL2L11
39	lactacystin32	6.0	BIRC5, PARP1, BCL2, CDKN1A, CDKN3, CDK4
40	pdtc32	5.8	BIRC3, BIRC5, PARP1, BCL2, XIAP, CDKN1A
41	doxorubicin32 34 9 9	8.8	BIRC2, BIRC3, PARP1, BAK1, XIAP, CDK4
42	retinoic acid32 42 18	7.2	PCYT1A, RBP1, SERPINF1, BIRC5, PARP1, PAX6
43	butyrate32	5.1	BIRC5, BCL2, BAK1, BAX, XIAP, CDKN1A
44	resveratrol32 9 18 9	7.7	BIRC5, PARP1, BCL2, BAK1, BAX, XIAP
45	paclitaxel32 34 9 9	6.5	BIRC2, BIRC3, BIRC5, PARP1, BCL2, BCL2L11
46	alanine32	INF	BIRC3, BIRC5, PABPN1, PAX6, BCL2L11, LCK
47	rapamycin32 42	INF	BECN1, BCL2L11, CDK4, , GTDC2, MAPK8
48	glutamate32	INF	SERPINF1, LCK, XIAP, CDKN3, , MCL1
49	phosphatidylinositol32	INF	BIRC3, BIRC5, BCL2, BCL2L11, ZAP70, LCK
50	ly29400232	INF	BIRC2, BIRC3, CDKN3, , FASLG, ANXA5

Cellular components related to ptosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	GSK3B, CBL, XIAP, MTM1, BAX, MCL1
2	cytosol	GO:005829	INF	PCYT1A, CDKN1A, CDK4, GSK3B, FADD, FAS
3	CD95 death-inducing signaling complex	GO:031265	10.2	CASP8, FADD, FAS
4	death-inducing signaling complex	GO:031264	9.9	FAS, CASP8, FADD
5	mitochondrial outer membrane	GO:005741	9.8	BAK1, OPA1, BCL2L11, BAX, BMF, BCL2
6	perinuclear region of cytoplasm	GO:048471	8.5	AIFM1, CTNNB1, NOS2, ACHE, CAV1, HSPA5
7	nucleoplasm	GO:005654	7.3	TOP1, MYF6, CASP7, CASP3, TP53, DDIT3
8	nucleus	GO:005634	INF	NPPA, RRM2B, E2F1, MAPK14, SOX14, SOD1
9	mitochondrion	GO:005739	INF	, TP53, MAPK14, E2F1, RRM2B, POLG

Biological processes related to ptosis according to GeneDecks:

(show all 45)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:007596	INF	TP53, NOS3, , , SYK, SOD1
2	regulation of nucleotide-binding oligomerization domain containing signaling pathway	GO:070424	10.6	BIRC3, XIAP, BIRC2
3	B cell apoptotic process	GO:001783	10.5	BAK1, BAX, BCL2L11
4	extrinsic apoptotic signaling pathway	GO:097191	10.4	TNFRSF10A, FADD, CASP8
5	induction of apoptosis via death domain receptors	GO:008625	10.4	FADD, FAS, FASLG, CASP3, TNFRSF10A, TNFRSF10B
6	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	GO:008635	10.4	BAX, CYCS, CASP3, CASP7, BAK1
7	positive regulation of neuron apoptotic process	GO:043525	10.3	BAX, FASLG, CASP3, CASP7, BCL2L11
8	positive regulation of protein homooligomerization	GO:032464	10.3	BCL2L11, BMF, FAS
9	cellular response to mechanical stimulus	GO:071260	10.2	TNFRSF10B, FAS, BAK1, FADD, MAPK8, MAP3K14
10	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:070059	10.2	BCL2, BAK1, BAX, AIFM1
11	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.2	CASP8, BIRC2, BIRC3, PRKCB, FASLG, TNFSF10
12	renal system process	GO:003014	10.2	FAS, BCL2, RRM2B
13	regulation of protein heterodimerization activity	GO:043497	10.2	BAX, BAK1, BCL2
14	B cell homeostasis	GO:001782	10.2	BAK1, CASP3, BCL2L11, BCL2, BAX
15	myeloid cell homeostasis	GO:002262	10.2	SOD1, BAX, BAK1, BCL2L11
16	regulation of protein homodimerization activity	GO:043496	10.2	BAK1, BAX, BCL2
17	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.0	BAX, BCL2L11, TNFSF10, TNFRSF10B, TNFRSF10A, AIFM1
18	apoptotic DNA fragmentation	GO:006309	10.0	SOD1, CYCS, FOXL2, BAX, CASP3, AIFM1
19	positive regulation of release of cytochrome c from mitochondria	GO:090200	10.0	BCL2L11, BAK1, TP53, BAX, BMF, TNFSF10
20	cellular component disassembly involved in apoptotic process	GO:006921	9.9	CTNNB1, CASP8, CASP3, CASP7, BIRC2
21	aging	GO:007568	9.9	SERPINF1, BAK1, FAS, CASP7, DDIT3, NOS3
22	regulation of mitochondrial membrane potential	GO:051881	9.8	SOD1, BAX, BAK1, BCL2
23	negative regulation of protein binding	GO:032091	9.8	MAPK8, BAX, GSK3B, CAV1
24	ER overload response	GO:006983	9.8	DDIT3, HSPA5, TP53, GSK3B
25	positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	9.7	CAV1, TP53, BCL2L11, BAX
26	induction of apoptosis by extracellular signals	GO:008624	9.7	FASLG, TNFSF10, TNFRSF10B, CAV1, CASP3, FADD
27	activation of pro-apoptotic gene products	GO:008633	9.6	BMF, BCL2, BCL2L11, BAK1, BAX, FASLG
28	release of cytochrome c from mitochondria	GO:001836	9.5	BCL2, SOD2, CASP3, CASP7, BAX, BAK1
29	response to gamma radiation	GO:010332	9.4	TP53, BAX, BCL2, CAV1, BAK1
30	neuron apoptotic process	GO:051402	9.4	BAX, BCL2, FAS, CASP3, AIFM1, TP53
31	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.4	CDKN1A, NFE2L2, TP53, MAPK14
32	induction of apoptosis	GO:006917	9.2	TNFRSF10A, PTEN, BCL2L11, TNFSF10, CASP3, FAS
33	response to DNA damage stimulus	GO:006974	9.2	BAX, XIAP, DDIT3, CDKN1A, TP53, CASP3
34	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.0	OSR2, TP53, DDIT3, CTNNB1, NR1H4, PHOX2A
35	peptidyl-serine phosphorylation	GO:018105	9.0	MAPK1, MAPK14, BCL2, ATR, GSK3B, MAPK8
36	induction of apoptosis by intracellular signals	GO:008629	8.8	BMF, TP53, CYCS, CASP8, BAX, BCL2
37	anti-apoptosis	GO:006916	8.7	BECN1, HSPB1, MCL1, GSK3B, XIAP, BCL2
38	virus-host interaction	GO:019048	8.5	FADD, LCK, PABPN1, BECN1, MAPK1, CASP8
39	negative regulation of apoptotic process	GO:043066	8.4	PTEN, CBL, RRM2B, SOD2, TP53, HSPB1
40	positive regulation of apoptotic process	GO:043065	8.3	DDIT3, FASLG, FOXL2, BAX, FADD, FAS
41	signal transduction	GO:007165	8.1	TNFRSF10A, TNFSF10, NR1H4, ANXA5, HSP90AA1, CHRND
42	negative regulation of cell proliferation	GO:008285	8.0	CDKN3, NOS3, TP53, CTNNB1, PTEN, BECN1
43	response to drug	GO:042493	7.8	LPL, NOS3, CTNNB1, DDIT3, CAV1, FAS
44	apoptotic process	GO:006915	6.4	MAPK14, MAPK8, FAS, FADD, FASLG, MCL1
45	mitochondrial fusion	GO:008053	INF	BAK1, , OPA1, BAX

Molecular functions related to ptosis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding transcription factor activity	GO:003700	INF	, ZFHX4, E2F1, ATF6, FOXC2, NFE2L2
2	acetylcholine-activated cation-selective channel activity	GO:004889	10.7	CHRNB1, CHRNE, CHRNG, CHRND
3	phosphatidylinositol-3-phosphatase activity	GO:004438	10.5	MTM1, PTEN, MTMR14
4	channel activity	GO:015267	10.3	BAX, CHRNB1, CHRNG, BCL2
5	BH3 domain binding	GO:051434	10.2	BAX, BCL2, MCL1
6	tumor necrosis factor receptor binding	GO:005164	9.9	FASLG, TNFSF10, CASP8, FADD
7	chaperone binding	GO:051087	9.2	BIRC5, SOD1, TP53, BAK1, HSPA5
8	protein heterodimerization activity	GO:046982	9.1	BAK1, MCL1, TP53, TWIST1, BAX, BCL2
9	transcription factor binding	GO:008134	9.0	TWIST1, TNFRSF10A, TP53, PAX6, FOXF2, BCL2
10	enzyme binding	GO:019899	8.7	BIRC5, PAWR, TP53, CSF3, DNM2, CTNNB1
11	ATP binding	GO:005524	INF	KIF21A, ABCC1, TP53, HSPA4, HSPA5, MAPK1
12	protein kinase binding	GO:019901	INF	PAX6, GSK3B, LCK, HSPB1, TP53, PTEN
13	protein binding	GO:005515	INF	CDKN1A, CBL, HSPA5, HSPB1, HSP90AA1, CASP7
14	sequence-specific DNA binding	GO:043565	INF	BCL2, E2F1, SOX14, OSR2, ZFHX4, ATF6
15	identical protein binding	GO:042802	INF	TP53, , HSP90AA1, FAS, FADD, BAK1