MCID: PLM006
MIFTS: 48

Pulmonary Alveolar Proteinosis malady

Categories: Respiratory diseases, Rare diseases, Blood diseases

Aliases & Classifications for Pulmonary Alveolar Proteinosis

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Aliases & Descriptions for Pulmonary Alveolar Proteinosis:

Name: Pulmonary Alveolar Proteinosis 11 27 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:12120
ICD1030 J84.01
ICD9CM32 516.0
SNOMED-CT62 10501004
MeSH39 D011649
NCIt45 C85037

Summaries for Pulmonary Alveolar Proteinosis

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Disease Ontology:11 A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange.

MalaCards based summary: Pulmonary Alveolar Proteinosis is related to pulmonary alveolar proteinosis, acquired and congenital pulmonary alveolar proteinosis, and has symptoms including hemoptysis and hemoptysis. An important gene associated with Pulmonary Alveolar Proteinosis is SFTPB (Surfactant Protein B), and among its related pathways are Cytokines and Inflammatory Response and Development of pulmonary dendritic cells and macrophage subsets. Affiliated tissues include lung, myeloid and bone, and related mouse phenotype respiratory system.

Wikipedia:71 Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which abnormal accumulation of pulmonary... more...

Related Diseases for Pulmonary Alveolar Proteinosis

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Diseases in the Pulmonary Alveolar Proteinosis family:

Pulmonary Alveolar Proteinosis, Acquired Congenital Pulmonary Alveolar Proteinosis
Hereditary Pulmonary Alveolar Proteinosis Secondary Pulmonary Alveolar Proteinosis

Diseases related to Pulmonary Alveolar Proteinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary alveolar proteinosis, acquired12.6
2congenital pulmonary alveolar proteinosis12.5
3hereditary pulmonary alveolar proteinosis12.3
4secondary pulmonary alveolar proteinosis12.3
5interstitial lung and liver disease11.9
6surfactant metabolism dysfunction, pulmonary, 111.7
7surfactant metabolism dysfunction, pulmonary, 511.7
8surfactant metabolism dysfunction, pulmonary, 411.7
9lysinuric protein intolerance11.4
10immunodeficiency 2111.2
11pulmonary surfactant metabolism dysfunction11.2
12surfactant metabolism dysfunction, pulmonary, 211.1
13surfactant metabolism dysfunction, pulmonary, 311.1
14abca3-related pulmonary surfactant metabolism dysfunction11.1
15csf2ra-related pulmonary surfactant metabolism dysfunction11.1
16csfrb-related pulmonary surfactant metabolism dysfunction11.1
17sftpb-related pulmonary surfactant metabolism dysfunction11.1
18sftpc-related pulmonary surfactant metabolism dysfunction11.1
19myelodysplastic syndrome10.3
20leukemia10.3
21pneumonia10.3
22pulmonary fibrosis10.2
23ectodermal dysplasia with natal teeth, turnpenny type10.2SFTPB, SFTPC
24back pain10.2SFTPB, SFTPC
25transverse myelitis10.2SFTPB, SFTPD
26respiratory failure10.2
27esophagus lymphoma10.2CSF2, SFTPB
28behavioral variant of frontotemporal dementia10.2CSF2RA, CSF2RB
29osteochondritis dissecans10.2SFTPB, SFTPC
30lung cancer10.1
31tuberculosis10.1
32common wart10.1SFTPB, SFTPC, SFTPD
33conjunctivochalasis10.1SFTPB, SFTPC, SFTPD
34adnp syndrome10.1SFTPB, SFTPC, SFTPD
35anogenital venereal wart10.0SFTPB, SFTPC, SFTPD
36cryptococcosis10.0
37lung disease10.0
38myeloid leukemia10.0
39imperforate anus10.0SFTPB, SFTPC
40medullary cystic kidney disease 110.0CSF2, CSF2RA, GATA2
41malignant oculomotor nerve tumor9.9CCL2, SFTPC
42systemic lupus erythematosus9.9
43aspergillosis9.9
44pick disease9.9
45arthritis9.9
46niemann-pick disease9.9
47silicosis9.9
48pneumothorax9.9
49squamous cell carcinoma9.9
50lung squamous cell carcinoma9.9

Graphical network of the top 20 diseases related to Pulmonary Alveolar Proteinosis:



Diseases related to pulmonary alveolar proteinosis

Symptoms & Phenotypes for Pulmonary Alveolar Proteinosis

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UMLS symptoms related to Pulmonary Alveolar Proteinosis:


hemoptysis

MGI Mouse Phenotypes related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.1CSF1, CSF2, CSF2RB, SFTPB, SFTPC, SFTPD

Drugs & Therapeutics for Pulmonary Alveolar Proteinosis

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Drugs for Pulmonary Alveolar Proteinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Anti-Bacterial AgentsPhase 2, Phase 311226
2AutoantibodiesPhase 2, Phase 3, Phase 1130
3Pulmonary SurfactantsPhase 2, Phase 3111
4Antibiotics, AntitubercularPhase 2, Phase 37180
5Pharmaceutical SolutionsPhase 2, Phase 3, Phase 18192
6molgramostimPhase 2, Phase 3, Phase 112
7
rituximabapprovedPhase 2, Phase 11692174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
8ImmunoglobulinsPhase 2, Phase 16394
9AntibodiesPhase 2, Phase 16394
10Antirheumatic AgentsPhase 2, Phase 110956
11Antibodies, MonoclonalPhase 14039
12
Nicotineapproved110354-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-(−)-nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(−)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-(N-methylpyrollidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
L(-)-nicotine
L(−)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
 
L-Nicotine
LS-202
MLS001055457
MLS001335905
Mach-Nic
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotrol
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch
13Respiratory System Agents4997
14Protein C118

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Whole Lung Lavage (WLL)/Inhaled Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) in Autoimmune Pulmonary Alveolar Proteinosis (PAP)Unknown statusNCT00901511Phase 2, Phase 3
2Efficacy and Safety of Inhaled Molgramostim (rhGM-CSF) in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)RecruitingNCT02702180Phase 2, Phase 3
3Prospective Trial of Rituximab for Primary Pulmonary Alveolar ProteinosisUnknown statusNCT00552461Phase 2
4Study of Subcutaneous Injection of Low-dose rhGM-CSF +/- WLL in PAP.Unknown statusNCT01983657Phase 2
5Inhaled Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in Hereditary Pulmonary Alveolar Proteinosis (PAP)CompletedNCT01511068Phase 2
6Inhalation of Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) for Autoimmune Pulmonary Alveolar Proteinosis (PAP)RecruitingNCT02243228Phase 2
7Pulmonary Alveolar Proteinosis GM-CSF Inhalation Efficacy Trial in JapanActive, not recruitingNCT02835742Phase 2
8GM-CSF in Patients With Pulmonary Alveolar ProteinosisTerminatedNCT00030056Phase 2
9SK-1401 (rhGM-CSF Agent for Inhalation) GM-CSF Inhalation Pharmacokinetic StudyCompletedNCT02840708Phase 1
10Inhaled Molgramostim (rhGM-CSF) in Healthy Adult SubjectsCompletedNCT02468908Phase 1
11Rituximab for Anti-cytokine Autoantibody-Associated DiseasesRecruitingNCT01842386Phase 1
12Evaluation of a Single Dose of Inhaled Sargramostim in Patients With Autoimmune Pulmonary Alveolar ProteinosisNot yet recruitingNCT03006146Phase 1
13Multicenter International Cross-Sectional Evaluation of Pulmonary Alveolar Proteinosis TrialCompletedNCT03007134
14A National Registry For Pulmonary Alveolar ProteinosisRecruitingNCT02461615
15Evaluation and Treatment Planning of Patients With PAP Using Thrive Ultra Short Echo Time MRI and CTRecruitingNCT02081092
16European Management Platform for Childhood Interstitial Lung Diseases - chILD-EU Register and BiobankRecruitingNCT02852928
17Natural History Study of GATA2 Deficiency and Related DisordersRecruitingNCT01905826
18Epidemiology of Surfactant Protein-B DeficiencyRecruitingNCT00014859

Search NIH Clinical Center for Pulmonary Alveolar Proteinosis


Cochrane evidence based reviews: pulmonary alveolar proteinosis

Genetic Tests for Pulmonary Alveolar Proteinosis

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Genetic tests related to Pulmonary Alveolar Proteinosis:

id Genetic test Affiliating Genes
1 Pulmonary Alveolar Proteinosis27

Anatomical Context for Pulmonary Alveolar Proteinosis

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MalaCards organs/tissues related to Pulmonary Alveolar Proteinosis:

36
Lung, Myeloid, Bone, Bone marrow, Monocytes, Testes, Breast

Publications for Pulmonary Alveolar Proteinosis

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Articles related to Pulmonary Alveolar Proteinosis:

(show top 50)    (show all 604)
idTitleAuthorsYear
1
Pulmonary Alveolar Proteinosis in Association with Secondary Hemophagocytic Lymphohistiocytosis. (28088396)
2017
2
Lung Transplant Recipient with Pulmonary Alveolar Proteinosis. (27213073)
2016
3
Management of pulmonary alveolar proteinosis with whole lung lavage using extracorporeal membrane oxygenation support in a postrenal transplant patient with graft failure. (27052091)
2016
4
Analysis of bronchoalveolar lavage fluid in a first Romanian pulmonary alveolar proteinosis cohort. (27833966)
2016
5
A Lung Lavage Technique in an Infant with Pulmonary Alveolar Proteinosis. (27424073)
2016
6
Role of granulocyte-macrophage colony-stimulating factor in pulmonary fibrosis following pulmonary alveolar proteinosis. (27512562)
2016
7
Disseminated Cryptococcosis Due to Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Absence of Pulmonary Alveolar Proteinosis. (28013480)
2016
8
Recurrence of pulmonary alveolar proteinosis after bilateral lung transplantation in a patient with a nonsense mutation in CSF2RB. (27595063)
2016
9
Two cases of autoimmune and secondary pulmonary alveolar proteinosis during immunosuppressive therapy in dermatomyositis with interstitial lung disease. (26872621)
2016
10
Association of pulmonary alveolar proteinosis and fibrosis: patient with GATA2 deficiency. (27799394)
2016
11
Anesthetic Management for Whole Lung Lavage in Patients with Pulmonary Alveolar Proteinosis. (26795910)
2016
12
Pulmonary alveolar proteinosis and Niemann Pick disease type B: An unexpected combination. (27408787)
2016
13
Whole Lung Lavage in a Pulmonary Alveolar Proteinosis Patient with Severe Respiratory Failure. (27366571)
2016
14
MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis. (27108412)
2016
15
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. (27453007)
2016
16
Rituximab improved systemic lupus erythematosus-associated pulmonary alveolar proteinosis without decreasing anti-GM-CSF antibody levels. (26843507)
2016
17
Death Due to Pulmonary Alveolar Proteinosis. (27879496)
2016
18
Pulmonary alveolar proteinosis: another autoimmune disease associated with sarcoidosis? (27055841)
2016
19
Autoantibody-Mediated Pulmonary Alveolar Proteinosis in Rasgrp1-Deficient Mice. (27279372)
2016
20
Increase in autoimmune pulmonary alveolar proteinosis after the 2011 Fukushima disaster. (26806057)
2016
21
Crazy-paving" pattern: A characteristic presentation of pulmonary alveolar proteinosis and a review of the literature from India. (27186004)
2016
22
Pulmonary alveolar proteinosis: Experience from a tertiary care center and systematic review of Indian literature. (27890991)
2016
23
Pulmonary alveolar proteinosis-like change: A fairly common reaction associated with the severity of idiopathic pulmonary fibrosis. (27424827)
2016
24
The Clinical Clues of Pulmonary Alveolar Proteinosis: A Report of 11 Cases and Literature Review. (27445535)
2016
25
Rare Presentation of Pulmonary Alveolar Proteinosis Causing Acute Respiratory Failure. (27445536)
2016
26
Successful Treatment of Autoimmune Pulmonary Alveolar Proteinosis in a Pediatric Patient. (27592713)
2016
27
Pulmonary Fibrosis on High-Resolution CT of Patients With Pulmonary Alveolar Proteinosis. (27548000)
2016
28
Inhaled Sargramostim Induces Resolution of Pulmonary Alveolar Proteinosis in Lysinuric Protein Intolerance. (27783330)
2016
29
Pulmonary alveolar proteinosis in a marble worker. (27518894)
2016
30
Abstract OR001: Extracorporeal Membrane Oxygenation to Support Whole Lung Lavage in A Patient with Pulmonary Alveolar Proteinosis. (27560787)
2016
31
A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis. (27635117)
2016
32
A Global Survey on Whole Lung Lavage in Pulmonary Alveolar Proteinosis. (27396783)
2016
33
Pulmonary Alveolar Proteinosis Syndrome. (27514590)
2016
34
Pulmonary Alveolar Proteinosis: Crazy Paving to Whole Lung Lavage. (27814844)
2016
35
Whole lung lavage therapy for pulmonary alveolar proteinosis: a global survey of current practices and procedures. (27577926)
2016
36
Induced sputum deposition improves diagnostic yields of pulmonary alveolar proteinosis: A clinicopathological and methodological study of 17 cases. (26583435)
2016
37
Pulmonary alveolar proteinosis: a case report and world literature review. (28031836)
2016
38
X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis. (27324886)
2016
39
A rare case of everolimus-induced pulmonary alveolar proteinosis. (26525403)
2015
40
Respiratory Strategies and Airway Management in Patients with Pulmonary Alveolar Proteinosis: A Review. (26495308)
2015
41
Whole Lung Lavage Treatment of Chinese Patients with Autoimmune Pulmonary Alveolar Proteinosis: A Retrospective Long-term Follow-up Study. (26481735)
2015
42
Anesthetic techniques to facilitate lung lavage for pulmonary alveolar proteinosis in children-new airway techniques and a review of the literature. (25664978)
2015
43
Possible Involvement of Lung Cells Harboring an Abnormal Karyotype in the Pathogenesis of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome. (26317278)
2015
44
Pulmonary alveolar proteinosis and clear cell renal cell carcinoma. (26148820)
2015
45
Extracorporeal membrane oxygenation to support repeated whole-lung lavage in a patient with pulmonary alveolar proteinosis in life threatening dyspnoe--a case report. (26621369)
2015
46
Rare combination of congenital heart disease and pulmonary alveolar proteinosis. (26310609)
2015
47
High fever and multi-nodular lung consolidations after whole lung lavage in a patient with pulmonary alveolar proteinosis. (25694861)
2015
48
Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis. (26077231)
2015
49
Pulmonary Alveolar Proteinosis: A Rare Cause of Respiratory Failure. (26208564)
2015
50
Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia. (25814803)
2015

Variations for Pulmonary Alveolar Proteinosis

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Expression for genes affiliated with Pulmonary Alveolar Proteinosis

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Search GEO for disease gene expression data for Pulmonary Alveolar Proteinosis.

Pathways for genes affiliated with Pulmonary Alveolar Proteinosis

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Pathways related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
19.8CSF1, CSF2
29.8CSF1, CSF2
39.7CSF2, SFTPD
49.6CCL2, CSF1
59.3CSF1, CSF2, CSF2RA
69.3CCL2, CSF2, SFTPC
79.2CCL2, CSF1, CSF2
89.2CCL2, CSF1, CSF2
99.2CCL2, CSF1, CSF2
109.2CCL2, CSF1, CSF2
11
Show member pathways
9.0CSF2, CSF2RA, CSF2RB
12
Show member pathways
9.0CSF2, CSF2RA, CSF2RB
139.0CCL2, CSF1, CSF2RB
148.9CSF1, CSF2, GATA2
158.5CCL2, CSF2RB, GATA2
16
Show member pathways
8.4CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
17
Show member pathways
8.4CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
18
Show member pathways
8.4CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
19
Show member pathways
8.2CCL2, CSF1, CSF2, CSF2RA, CSF2RB
20
Show member pathways
8.2CCL2, CSF1, CSF2, CSF2RA, CSF2RB
21
Show member pathways
8.2CCL2, CSF1, CSF2, CSF2RA, CSF2RB

GO Terms for genes affiliated with Pulmonary Alveolar Proteinosis

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Cellular components related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:003013910.3CCL2, SFTPD
2clathrin-coated endocytic vesicleGO:004533410.2SFTPB, SFTPC, SFTPD
3multivesicular body lumenGO:00974869.9SFTPB, SFTPC
4lamellar bodyGO:00425999.6SFTPB, SFTPC, SFTPD
5extracellular spaceGO:00056158.5CCL2, CSF1, CSF2, SFTPB, SFTPC, SFTPD
6extracellular regionGO:00055768.5CCL2, CSF1, CSF2, CSF2RA, SFTPB, SFTPC

Biological processes related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1macrophage chemotaxisGO:004824610.3CCL2, SFTPD
2positive regulation of macrophage derived foam cell differentiationGO:001074410.2CSF1, CSF2
3cellular response to platelet-derived growth factor stimulusGO:003612010.2CCL2, MARS
4positive regulation of macrophage chemotaxisGO:001075910.1CCL2, CSF1
5homeostasis of number of cells within a tissueGO:004887310.0CSF1, GATA2
6embryonic placenta developmentGO:000189210.0CSF2, GATA2
7peptidyl-tyrosine phosphorylationGO:00181089.7CSF2, CSF2RA, CSF2RB
8positive regulation of phagocytosisGO:00507669.7GATA2, SFTPD
9cytokine-mediated signaling pathwayGO:00192219.6CCL2, CSF2RA, CSF2RB
10MAPK cascadeGO:00001659.2CCL2, CSF2, CSF2RA, CSF2RB
11positive regulation of GTPase activityGO:00435479.0CCL2, CSF2, CSF2RA, CSF2RB
12respiratory gaseous exchangeGO:00075858.8CSF2RB, SFTPB, SFTPC, SFTPD
13cellular protein metabolic processGO:00442678.7CSF1, CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD

Molecular functions related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:000489610.0CSF2RA, CSF2RB
2cytokine activityGO:00051259.9CCL2, CSF1, CSF2
3protein tyrosine kinase activityGO:00047139.6CSF2, CSF2RA, CSF2RB
4Ras guanyl-nucleotide exchange factor activityGO:00050889.0CSF2, CSF2RA, CSF2RB

Sources for Pulmonary Alveolar Proteinosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet