MCID: PLM006
MIFTS: 48

Pulmonary Alveolar Proteinosis malady

Categories: Respiratory diseases, Rare diseases, Blood diseases

Aliases & Classifications for Pulmonary Alveolar Proteinosis

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Aliases & Descriptions for Pulmonary Alveolar Proteinosis:

Name: Pulmonary Alveolar Proteinosis 11 27 50 39 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:12120
ICD1030 J84.01
ICD9CM32 516.0
SNOMED-CT62 10501004
MeSH39 D011649
NCIt45 C85037

Summaries for Pulmonary Alveolar Proteinosis

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Disease Ontology:11 A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange.

MalaCards based summary: Pulmonary Alveolar Proteinosis is related to myelodysplastic syndrome and pulmonary alveolar proteinosis, acquired, and has symptoms including hemoptysis and hemoptysis. An important gene associated with Pulmonary Alveolar Proteinosis is MARS (Methionyl-TRNA Synthetase), and among its related pathways are Cytokines and Inflammatory Response and Regulation of retinoblastoma protein. Affiliated tissues include lung, myeloid and bone, and related mouse phenotype respiratory system.

Wikipedia:71 Pulmonary alveolar proteinosis (abbreviated PAP), is a rare lung disease in which abnormal accumulation... more...

Related Diseases for Pulmonary Alveolar Proteinosis

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Diseases in the Pulmonary Alveolar Proteinosis family:

Pulmonary Alveolar Proteinosis, Acquired Congenital Pulmonary Alveolar Proteinosis
Hereditary Pulmonary Alveolar Proteinosis Secondary Pulmonary Alveolar Proteinosis

Diseases related to Pulmonary Alveolar Proteinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1myelodysplastic syndrome29.9CSF1, CSF2, GATA2
2pulmonary alveolar proteinosis, acquired12.6
3hereditary pulmonary alveolar proteinosis12.3
4congenital pulmonary alveolar proteinosis12.3
5secondary pulmonary alveolar proteinosis12.3
6interstitial lung and liver disease11.9
7surfactant metabolism dysfunction, pulmonary, 111.7
8surfactant metabolism dysfunction, pulmonary, 511.7
9surfactant metabolism dysfunction, pulmonary, 411.7
10lysinuric protein intolerance11.5
11immunodeficiency 2111.3
12pulmonary surfactant metabolism dysfunction11.2
13surfactant metabolism dysfunction, pulmonary, 211.1
14surfactant metabolism dysfunction, pulmonary, 311.1
15abca3-related pulmonary surfactant metabolism dysfunction11.1
16csf2ra-related pulmonary surfactant metabolism dysfunction11.1
17csfrb-related pulmonary surfactant metabolism dysfunction11.1
18sftpb-related pulmonary surfactant metabolism dysfunction11.1
19sftpc-related pulmonary surfactant metabolism dysfunction11.1
20anonychia with flexural pigmentation10.4SFTPB, SFTPC
21band keratopathy10.4SFTPB, SFTPC
22aids - neurological complications10.4SFTPB, SFTPC
23osteoarthritis10.4SFTPB, SFTPC
24leukemia10.3
25mounier-kuhn syndrome10.3SFTPB, SFTPD
26burns10.3SFTPB, SFTPC
27pneumonia10.3
28pulmonary fibrosis10.2
29intestinal atresia10.2SFTPB, SFTPC
30respiratory failure10.2
31lung cancer10.1
32tuberculosis10.1
33coronary restenosis10.1SFTPB, SFTPC, SFTPD
34cryptococcosis10.0
35lung disease10.0
36myeloid leukemia10.0
37sterility due to immotile flagella10.0CCL2, CSF1
38systemic lupus erythematosus9.9
39aspergillosis9.9
40pick disease9.9
41arthritis9.9
42niemann-pick disease9.9
43silicosis9.9
44pneumothorax9.9
45lung squamous cell carcinoma9.9
46mediastinitis9.9
47lupus erythematosus9.9
48psoriasis9.9
49amyloidosis9.9
50sinusitis9.9CCL2, SFTPD

Graphical network of the top 20 diseases related to Pulmonary Alveolar Proteinosis:



Diseases related to pulmonary alveolar proteinosis

Symptoms & Phenotypes for Pulmonary Alveolar Proteinosis

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UMLS symptoms related to Pulmonary Alveolar Proteinosis:


hemoptysis

MGI Mouse Phenotypes related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.0CSF1, CSF2, CSF2RB, SFTPB, SFTPC, SFTPD

Drugs & Therapeutics for Pulmonary Alveolar Proteinosis

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Drugs for Pulmonary Alveolar Proteinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Anti-Bacterial AgentsPhase 2, Phase 310884
2AutoantibodiesPhase 2, Phase 3, Phase 1126
3Pulmonary SurfactantsPhase 2, Phase 3107
4Antibiotics, AntitubercularPhase 2, Phase 36972
5Pharmaceutical SolutionsPhase 2, Phase 3, Phase 17793
6molgramostimPhase 2, Phase 3, Phase 112
7
rituximabapprovedPhase 2, Phase 11654174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
8ImmunoglobulinsPhase 2, Phase 16045
9AntibodiesPhase 2, Phase 16045
10Antirheumatic AgentsPhase 2, Phase 110627
11Antibodies, MonoclonalPhase 13795
12
Nicotineapproved105054-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-(−)-nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(−)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-(N-methylpyrollidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
L(-)-nicotine
L(−)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
 
L-Nicotine
LS-202
MLS001055457
MLS001335905
Mach-Nic
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotrol
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch
13Respiratory System Agents4818
14Protein C115

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Whole Lung Lavage (WLL)/Inhaled Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) in Autoimmune Pulmonary Alveolar Proteinosis (PAP)Unknown statusNCT00901511Phase 2, Phase 3
2Efficacy and Safety of Inhaled Molgramostim (rhGM-CSF) in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)RecruitingNCT02702180Phase 2, Phase 3
3Prospective Trial of Rituximab for Primary Pulmonary Alveolar ProteinosisUnknown statusNCT00552461Phase 2
4Study of Subcutaneous Injection of Low-dose rhGM-CSF +/- WLL in PAP.Unknown statusNCT01983657Phase 2
5Inhaled Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in Hereditary Pulmonary Alveolar Proteinosis (PAP)CompletedNCT01511068Phase 2
6Inhalation of Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) for Autoimmune Pulmonary Alveolar Proteinosis (PAP)RecruitingNCT02243228Phase 2
7Pulmonary Alveolar Proteinosis GM-CSF Inhalation Efficacy Trial in JapanActive, not recruitingNCT02835742Phase 2
8GM-CSF in Patients With Pulmonary Alveolar ProteinosisTerminatedNCT00030056Phase 2
9SK-1401 (rhGM-CSF Agent for Inhalation) GM-CSF Inhalation Pharmacokinetic StudyCompletedNCT02840708Phase 1
10Inhaled Molgramostim (rhGM-CSF) in Healthy Adult SubjectsCompletedNCT02468908Phase 1
11Rituximab for Anti-cytokine Autoantibody-Associated DiseasesRecruitingNCT01842386Phase 1
12Evaluation of a Single Dose of Inhaled Sargramostim in Patients With Autoimmune Pulmonary Alveolar ProteinosisNot yet recruitingNCT03006146Phase 1
13Multicenter International Cross-Sectional Evaluation of Pulmonary Alveolar Proteinosis TrialCompletedNCT03007134
14A National Registry For Pulmonary Alveolar ProteinosisRecruitingNCT02461615
15Evaluation and Treatment Planning of Patients With PAP Using Thrive Ultra Short Echo Time MRI and CTRecruitingNCT02081092
16European Management Platform for Childhood Interstitial Lung Diseases - chILD-EU Register and BiobankRecruitingNCT02852928
17Natural History Study of GATA2 Deficiency and Related DisordersRecruitingNCT01905826
18Epidemiology of Surfactant Protein-B DeficiencyRecruitingNCT00014859

Search NIH Clinical Center for Pulmonary Alveolar Proteinosis


Cochrane evidence based reviews: pulmonary alveolar proteinosis

Genetic Tests for Pulmonary Alveolar Proteinosis

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Genetic tests related to Pulmonary Alveolar Proteinosis:

id Genetic test Affiliating Genes
1 Pulmonary Alveolar Proteinosis27

Anatomical Context for Pulmonary Alveolar Proteinosis

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MalaCards organs/tissues related to Pulmonary Alveolar Proteinosis:

36
Lung, Myeloid, Bone, Bone marrow, Monocytes, Testes, Heart

Publications for Pulmonary Alveolar Proteinosis

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Articles related to Pulmonary Alveolar Proteinosis:

(show top 50)    (show all 604)
idTitleAuthorsYear
1
Pulmonary Alveolar Proteinosis in Association with Secondary Hemophagocytic Lymphohistiocytosis. (28088396)
2017
2
Pulmonary Fibrosis on High-Resolution CT of Patients With Pulmonary Alveolar Proteinosis. (27548000)
2016
3
Induced sputum deposition improves diagnostic yields of pulmonary alveolar proteinosis: A clinicopathological and methodological study of 17 cases. (26583435)
2016
4
Inhaled Sargramostim Induces Resolution of Pulmonary Alveolar Proteinosis in Lysinuric Protein Intolerance. (27783330)
2016
5
Pulmonary alveolar proteinosis in a marble worker. (27518894)
2016
6
Pulmonary alveolar proteinosis-like change: A fairly common reaction associated with the severity of idiopathic pulmonary fibrosis. (27424827)
2016
7
Anesthetic Management for Whole Lung Lavage in Patients with Pulmonary Alveolar Proteinosis. (26795910)
2016
8
Autoantibody-Mediated Pulmonary Alveolar Proteinosis in Rasgrp1-Deficient Mice. (27279372)
2016
9
The Clinical Clues of Pulmonary Alveolar Proteinosis: A Report of 11 Cases and Literature Review. (27445535)
2016
10
Pulmonary Alveolar Proteinosis: Crazy Paving to Whole Lung Lavage. (27814844)
2016
11
Pulmonary alveolar proteinosis and Niemann Pick disease type B: An unexpected combination. (27408787)
2016
12
Death Due to Pulmonary Alveolar Proteinosis. (27879496)
2016
13
A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis. (27635117)
2016
14
Recurrence of pulmonary alveolar proteinosis after bilateral lung transplantation in a patient with a nonsense mutation in CSF2RB. (27595063)
2016
15
Rare Presentation of Pulmonary Alveolar Proteinosis Causing Acute Respiratory Failure. (27445536)
2016
16
Pulmonary alveolar proteinosis: a case report and world literature review. (28031836)
2016
17
Association of pulmonary alveolar proteinosis and fibrosis: patient with GATA2 deficiency. (27799394)
2016
18
Role of granulocyte-macrophage colony-stimulating factor in pulmonary fibrosis following pulmonary alveolar proteinosis. (27512562)
2016
19
Lung Transplant Recipient with Pulmonary Alveolar Proteinosis. (27213073)
2016
20
Abstract OR001: Extracorporeal Membrane Oxygenation to Support Whole Lung Lavage in A Patient with Pulmonary Alveolar Proteinosis. (27560787)
2016
21
Rituximab improved systemic lupus erythematosus-associated pulmonary alveolar proteinosis without decreasing anti-GM-CSF antibody levels. (26843507)
2016
22
Disseminated Cryptococcosis Due to Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Absence of Pulmonary Alveolar Proteinosis. (28013480)
2016
23
Crazy-paving" pattern: A characteristic presentation of pulmonary alveolar proteinosis and a review of the literature from India. (27186004)
2016
24
Pulmonary alveolar proteinosis: Experience from a tertiary care center and systematic review of Indian literature. (27890991)
2016
25
MUC1 gene polymorphisms are associated with serum KL-6 levels and pulmonary dysfunction in pulmonary alveolar proteinosis. (27108412)
2016
26
A Global Survey on Whole Lung Lavage in Pulmonary Alveolar Proteinosis. (27396783)
2016
27
A Lung Lavage Technique in an Infant with Pulmonary Alveolar Proteinosis. (27424073)
2016
28
Pulmonary Alveolar Proteinosis Syndrome. (27514590)
2016
29
Pulmonary alveolar proteinosis: another autoimmune disease associated with sarcoidosis? (27055841)
2016
30
Whole lung lavage therapy for pulmonary alveolar proteinosis: a global survey of current practices and procedures. (27577926)
2016
31
Two cases of autoimmune and secondary pulmonary alveolar proteinosis during immunosuppressive therapy in dermatomyositis with interstitial lung disease. (26872621)
2016
32
X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis. (27324886)
2016
33
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. (27453007)
2016
34
Whole Lung Lavage in a Pulmonary Alveolar Proteinosis Patient with Severe Respiratory Failure. (27366571)
2016
35
Successful Treatment of Autoimmune Pulmonary Alveolar Proteinosis in a Pediatric Patient. (27592713)
2016
36
Analysis of bronchoalveolar lavage fluid in a first Romanian pulmonary alveolar proteinosis cohort. (27833966)
2016
37
Management of pulmonary alveolar proteinosis with whole lung lavage using extracorporeal membrane oxygenation support in a postrenal transplant patient with graft failure. (27052091)
2016
38
Increase in autoimmune pulmonary alveolar proteinosis after the 2011 Fukushima disaster. (26806057)
2016
39
Localized Airspace Consolidation of Pulmonary Alveolar Proteinosis Mimicking Malignant Lesions in 18F-FDG PET/CT Imaging: One Case Report. (26252337)
2015
40
Pulmonary alveolar proteinosis in a cat. (26646313)
2015
41
Autoimmune pulmonary alveolar proteinosis with primary lung cancer in a patient of very advanced years. (25899759)
2015
42
Whole Lung Lavage Treatment of Chinese Patients with Autoimmune Pulmonary Alveolar Proteinosis: A Retrospective Long-term Follow-up Study. (26481735)
2015
43
High fever and multi-nodular lung consolidations after whole lung lavage in a patient with pulmonary alveolar proteinosis. (25694861)
2015
44
Pulmonary alveolar proteinosis and clear cell renal cell carcinoma. (26148820)
2015
45
Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis. (26077231)
2015
46
A rare cause of fatal pulmonary alveolar proteinosis: Niemann-Pick disease type C2 and a novel mutation. (26024245)
2015
47
A rare case of everolimus-induced pulmonary alveolar proteinosis. (26525403)
2015
48
Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia. (25814803)
2015
49
Pulmonary alveolar proteinosis induced by hydrofluoric acid exposure during fire extinguisher testing. (25737738)
2015
50
A plasmapheresis protocol for refractory pulmonary alveolar proteinosis. (25557091)
2015

Variations for Pulmonary Alveolar Proteinosis

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Clinvar genetic disease variations for Pulmonary Alveolar Proteinosis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1MARSNM_004990.3(MARS): c.1814A> T (p.Asp605Val)SNVPathogenicrs756021768GRCh38Chr 12, 57512811: 57512811

Expression for genes affiliated with Pulmonary Alveolar Proteinosis

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Search GEO for disease gene expression data for Pulmonary Alveolar Proteinosis.

Pathways for genes affiliated with Pulmonary Alveolar Proteinosis

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Pathways related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.7CSF1, CSF2
29.6CSF2, SFTPD
39.5CCL2, CSF1
49.1CCL2, CSF1, CSF2
59.1CCL2, CSF1, CSF2
69.1CCL2, CSF1, CSF2
79.0CCL2, CSF1, CSF2RB
88.9CSF1, CSF2, CSF2RA
98.8CCL2, CSF2RB, GATA2
10
Show member pathways
8.7CSF2, CSF2RA, CSF2RB
11
Show member pathways
8.0CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
12
Show member pathways
8.0CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
13
Show member pathways
7.7CCL2, CSF1, CSF2, CSF2RA, CSF2RB
14
Show member pathways
7.7CCL2, CSF1, CSF2, CSF2RA, CSF2RB
15
Show member pathways
7.4CCL2, CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD

GO Terms for genes affiliated with Pulmonary Alveolar Proteinosis

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Cellular components related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:003013910.2CCL2, SFTPD
2clathrin-coated endocytic vesicleGO:004533410.1SFTPB, SFTPC, SFTPD
3multivesicular body lumenGO:00974869.8SFTPB, SFTPC
4lamellar bodyGO:00425999.5SFTPB, SFTPC, SFTPD
5extracellular spaceGO:00056158.2CCL2, CSF1, CSF2, SFTPB, SFTPC, SFTPD
6extracellular regionGO:00055768.2CCL2, CSF2, CSF2RA, SFTPB, SFTPC, SFTPD

Biological processes related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1homeostasis of number of cells within a tissueGO:004887310.3CSF1, GATA2
2embryonic placenta developmentGO:000189210.3CSF2, GATA2
3positive regulation of macrophage derived foam cell differentiationGO:001074410.2CSF1, CSF2
4macrophage chemotaxisGO:004824610.1CCL2, SFTPD
5positive regulation of macrophage chemotaxisGO:001075910.0CCL2, CSF1
6positive regulation of phagocytosisGO:00507669.9GATA2, SFTPD
7animal organ morphogenesisGO:00098879.7CCL2, GATA2, SFTPB
8peptidyl-tyrosine phosphorylationGO:00181089.4CSF2, CSF2RA, CSF2RB
9respiratory gaseous exchangeGO:00075858.8CSF2RB, SFTPB, SFTPC, SFTPD
10MAPK cascadeGO:00001658.8CCL2, CSF2, CSF2RA, CSF2RB
11cellular protein metabolic processGO:00442678.7CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
12positive regulation of GTPase activityGO:00435478.6CCL2, CSF2, CSF2RA, CSF2RB

Molecular functions related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor bindingGO:000166410.1CCL2, SFTPB
2cytokine activityGO:00051259.7CCL2, CSF1, CSF2
3protein tyrosine kinase activityGO:00047139.3CSF2, CSF2RA, CSF2RB
4Ras guanyl-nucleotide exchange factor activityGO:00050888.7CSF2, CSF2RA, CSF2RB

Sources for Pulmonary Alveolar Proteinosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet