MCID: PLM006
MIFTS: 41

Pulmonary Alveolar Proteinosis malady

Respiratory diseases, Rare diseases categories

Aliases & Classifications for Pulmonary Alveolar Proteinosis

About this section
Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 24GTR, 65UMLS, 36MeSH, 59SNOMED-CT, 29ICD9CM, 42NCIt
See all sources

Aliases & Descriptions for Pulmonary Alveolar Proteinosis:

Name: Pulmonary Alveolar Proteinosis 10 47 12 24 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:12120
ICD9CM29 516.0
SNOMED-CT59 10501004
MeSH36 D011649
NCIt42 C85037

Summaries for Pulmonary Alveolar Proteinosis

About this section
Disease Ontology:10 A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange.

MalaCards based summary: Pulmonary Alveolar Proteinosis is related to myelodysplastic syndrome and niemann-pick disease. An important gene associated with Pulmonary Alveolar Proteinosis is SFTPB (Surfactant Protein B), and among its related pathways are Cytokines and Inflammatory Response and Regulation of retinoblastoma protein. Affiliated tissues include lung, bone and myeloid, and related mouse phenotypes are reproductive system and respiratory system.

Related Diseases for Pulmonary Alveolar Proteinosis

About this section

Diseases in the Pulmonary Alveolar Proteinosis family:

Congenital Pulmonary Alveolar Proteinosis Pulmonary Alveolar Proteinosis Acquired
Hereditary Pulmonary Alveolar Proteinosis Secondary Pulmonary Alveolar Proteinosis

Diseases related to Pulmonary Alveolar Proteinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1myelodysplastic syndrome31.0CSF1, CSF2, GATA2
2niemann-pick disease30.7SFTPB, SFTPC
3diarrhea30.6SFTPB, SFTPC
4histoplasmosis30.4CSF1, CSF2
5pneumothorax30.4CCL2, SFTPB, SFTPC, SFTPD
6secondary pulmonary alveolar proteinosis10.9
7congenital pulmonary alveolar proteinosis10.9
8leukemia10.8
9hereditary pulmonary alveolar proteinosis10.8
10pneumonia10.8
11pulmonary alveolar proteinosis acquired10.8
12lung cancer10.6
13pulmonary fibrosis10.6
14tuberculosis10.6
15lysinuric protein intolerance10.6
16respiratory failure10.6
17interstitial lung and liver disease10.5
18frontotemporal lobar degeneration with ubiquitin-positive inclusions10.5
19myeloid leukemia10.5
20early-onset pulmonary alveolar proteinosis due to mars deficiency10.5
21autoimmune disease 110.4
22surfactant metabolism dysfunction, pulmonary, 110.4
23immunodeficiency 2110.4
24autoimmune disease 210.4
25autoimmune disease 610.4
26surfactant metabolism dysfunction, pulmonary, 510.4
27surfactant metabolism dysfunction, pulmonary, 410.4
28arthritis10.4
29silicosis10.4
30cryptococcosis10.4
31desquamative interstitial pneumonia10.4
32amyloidosis10.4
33brucellosis10.4
34hypersensitivity reaction type ii disease10.4
35lung squamous cell carcinoma10.4
36mediastinitis10.4
37psoriasis10.4
38systemic lupus erythematosus10.3
39breast cancer10.3
40anemia, sideroblastic, pyridoxine-refractory, autosomal recessive10.3
41coronary heart disease 510.3
42renal cell carcinoma10.3
43pulmonary alveolar microlithiasis10.3
44autoimmune disease 410.3
45membranous nephropathy10.3
46surfactant metabolism dysfunction, pulmonary, 210.3
47diarrhea 710.3
48autoimmune disease 310.3
49lymphangioleiomyomatosis10.3
50multiple myeloma10.3

Graphical network of the top 20 diseases related to Pulmonary Alveolar Proteinosis:



Diseases related to pulmonary alveolar proteinosis

Symptoms for Pulmonary Alveolar Proteinosis

About this section

Drugs & Therapeutics for Pulmonary Alveolar Proteinosis

About this section

Drugs for Pulmonary Alveolar Proteinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pulmonary SurfactantsPhase 2, Phase 399
2
rituximabapprovedPhase 2, Phase 11514174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
3molgramostimPhase 111
4
Nicotineapproved92354-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(+-)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(R,S)-nicotine
(RS)-nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(┬▒)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
American Fare Nicotine Transdermal System
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Careone Nicotine Transdermal System Step 1
Careone Nicotine Transdermal System Step 2
Careone Nicotine Transdermal System Step 3
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Equaline Nicotine Transdermal System STEP 1
Exchange Select Nicotine Transdermal System STEP 3
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
Habitrol Patch Nicotine Transdermal System, Step 1
Habitrol Patch Nicotine Transdermal System, Step 2
Habitrol Patch Nicotine Transdermal System, Step 3
Healthmart Nicotine Transdermal System STEP 1
Healthmart Nicotine Transdermal System STEP 2
Healthmart Nicotine Transdermal System STEP 3
Kroger Nicotine Transdermal System STEP 1
Kroger Nicotine Transdermal System STEP 2
Kroger Nicotine Transdermal System STEP 3
L(-)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
L-Nicotine
LS-202
Leader Nicotine
Leader Nicotine Transdermal System STEP 1
Leader Nicotine Transdermal System STEP 2
Leader Nicotine Transdermal System STEP 3
MLS001055457
 
MLS001335905
Mach-Nic
Meijer Nicotine Transdermal System STEP 2
Meijer Nicotine Transdermal System Step 1
Meijer Nicotine Transdermal System Step 3
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm CQ
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine TRANSDERMAL SYSTEM
Nicotine Transdermal System PATCH KIT
Nicotine Transdermal System STEP 1
Nicotine Transdermal System STEP 2
Nicotine Transdermal System STEP 3
Nicotine Transdermal System Step 1
Nicotine Transdermal System Step 2
Nicotine Transdermal System Step 3
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotine transdermal system
Nicotrol
Nicotrol (professional Sample)
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
Rite Aid Nicotine Transdermal System Step 1
Rite Aid Nicotine Transdermal System Step 2
Rite Aid Nicotine Transdermal System Step 3
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Safeway Nicotine Transdermal System STEP 1
Safeway Nicotine Transdermal System STEP 2
Safeway Nicotine Transdermal System STEP 3
Smart Sense Nicotine
Sunmark Nicotine
Sunmark Nicotine Transdermal System STEP 1
Sunmark Nicotine Transdermal System STEP 2
Sunmark Nicotine Transdermal System STEP 3
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch
5Protein C82

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Whole Lung Lavage (WLL)/Inhaled Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) in Autoimmune Pulmonary Alveolar Proteinosis (PAP)Enrolling by invitationNCT00901511Phase 2, Phase 3
2Inhaled Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in Hereditary Pulmonary Alveolar Proteinosis (PAP)CompletedNCT01511068Phase 2
3Prospective Trial of Rituximab for Primary Pulmonary Alveolar ProteinosisRecruitingNCT00552461Phase 2
4Inhalation of Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) for Autoimmune Pulmonary Alveolar Proteinosis (PAP)RecruitingNCT02243228Phase 2
5Study of Subcutaneous Injection of Low-dose rhGM-CSF +/- WLL in PAP.RecruitingNCT01983657Phase 2
6GM-CSF in Patients With Pulmonary Alveolar ProteinosisTerminatedNCT00030056Phase 2
7Inhaled Molgramostim (rhGM-CSF) in Healthy Adult SubjectsCompletedNCT02468908Phase 1
8Rituximab for Anti-cytokine Autoantibody-Associated DiseasesRecruitingNCT01842386Phase 1
9A National Registry For Pulmonary Alveolar ProteinosisRecruitingNCT02461615
10Evaluation and Treatment Planning of Patients With PAP Using Thrive Ultra Short Echo Time MRI and CTRecruitingNCT02081092
11Natural History Study of GATA2 Deficiency and Related DisordersRecruitingNCT01905826
12Epidemiology of Surfactant Protein-B DeficiencyRecruitingNCT00014859

Search NIH Clinical Center for Pulmonary Alveolar Proteinosis


Cochrane evidence based reviews: Pulmonary Alveolar Proteinosis

Genetic Tests for Pulmonary Alveolar Proteinosis

About this section

Genetic tests related to Pulmonary Alveolar Proteinosis:

id Genetic test Affiliating Genes
1 Pulmonary Alveolar Proteinosis24

Anatomical Context for Pulmonary Alveolar Proteinosis

About this section

MalaCards organs/tissues related to Pulmonary Alveolar Proteinosis:

33
Lung, Bone, Myeloid, Bone marrow, Monocytes, Testes, Breast

Animal Models for Pulmonary Alveolar Proteinosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Pulmonary Alveolar Proteinosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.3CCL2, CSF1, CSF2, GATA2, SFTPC
2MP:00053887.8CSF1, CSF2, CSF2RB, SFTPB, SFTPC, SFTPD
3MP:00107687.7CCL2, CSF1, CSF2, GATA2, SFTPB, SFTPC
4MP:00053877.4CCL2, CSF1, CSF2, CSF2RB, SFTPC, SFTPD
5MP:00053977.1CCL2, CSF1, CSF2, CSF2RB, GATA2, SFTPD
6MP:00053767.0CCL2, CSF1, CSF2, CSF2RB, GATA2, SFTPB

Publications for Pulmonary Alveolar Proteinosis

About this section

Articles related to Pulmonary Alveolar Proteinosis:

(show top 50)    (show all 553)
idTitleAuthorsYear
1
Localized Airspace Consolidation of Pulmonary Alveolar Proteinosis Mimicking Malignant Lesions in 18F-FDG PET/CT Imaging: One Case Report. (26252337)
2015
2
Pulmonary Alveolar Proteinosis: A Rare Cause of Respiratory Failure. (26208564)
2015
3
Secondary pulmonary alveolar proteinosis in hematologic malignancies. (25300566)
2014
4
Localized pulmonary alveolar proteinosis: two case reports. (25337424)
2014
5
A crazy cause of dyspnoea: pulmonary alveolar proteinosis. (25152273)
2014
6
Development of pulmonary alveolar proteinosis following exposure to dust after the Great East Japan Earthquake. (24238228)
2013
7
De novo complex X chromosome rearrangement unmasking maternally inherited CSF2RA deletion in a girl with pulmonary alveolar proteinosis. (23918747)
2013
8
Pulmonary alveolar proteinosis requiring "hybrid" extracorporeal life support, and complicated by acute necrotizing pneumonia. (23523160)
2013
9
Standardized serum GM-CSF autoantibody testing for the routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis. (24275678)
2013
10
Extracorporeal membrane oxygenation to support whole-lung lavage in pulmonary alveolar proteinosis: salvage of the drowned lungs. (23328142)
2013
11
Pulmonary alveolar proteinosis: quantitative CT and pulmonary functional correlations. (21621361)
2012
12
Spontaneous pulmonary alveolar proteinosis in captive "moustached tamarins" (Saguinus mystax). (21734058)
2012
13
Pulmonary alveolar proteinosis in an indium-processing worker. (20529594)
2010
14
Pulmonary alveolar proteinosis in a 67-year-old woman with Wegener's granulomatosis. (20623200)
2010
15
Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. (20224064)
2010
16
Whole-lung lavage in infants and children with pulmonary alveolar proteinosis. (21199121)
2010
17
F-18 FDG PET/CT in pulmonary alveolar proteinosis. (19352264)
2009
18
Differences in the immunolocalization of surfactant protein (SP)-A, SP-D, and KL-6 in pulmonary alveolar proteinosis. (18251786)
2008
19
Secondary pulmonary alveolar proteinosis in a patient with chronic myeloid leukemia in the accelerated phase. (21318986)
2008
20
GM-CSF autoantibodies in pulmonary alveolar proteinosis. (17506160)
2007
21
Pulmonary alveolar proteinosis--is host defense awry? (17287475)
2007
22
Pulmonary alveolar proteinosis. (16916009)
2006
23
Pulmonary alveolar proteinosis with myeloproliferative syndrome with myelodysplasia: bronchoalveolar lavage reduces white blood cell count. (16906593)
2006
24
Serum antibody against granulocyte/macrophage colony-stimulating factor and KL-6 in idiopathic pulmonary alveolar proteinosis. (16565598)
2006
25
Pulmonary alveolar proteinosis. What is the role of GM-CSF in disease pathogenesis and treatment? (15350161)
2004
26
Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome. (12636240)
2003
27
Detection of granulocyte-macrophage colony-stimulating factor in patients with pulmonary alveolar proteinosis. (10764326)
2000
28
Pulmonary alveolar proteinosis in a child: HRCT findings before and after bronchoalveolar lavage. (9866787)
1998
29
Serum KL-6 level as a monitoring marker in a patient with pulmonary alveolar proteinosis. (10319067)
1998
30
Pulmonary alveolar proteinosis with respiratory failure--therapeutic role of bronchoscopic and whole lung lavage. (11229289)
1998
31
Immunoglobulin G is associated with surfactant protein A aggregate isolated from patients with pulmonary alveolar proteinosis. (9154892)
1997
32
Pulmonary alveolar proteinosis. (9157392)
1997
33
Bronchoalveolar lavage cytology in pulmonary alveolar proteinosis. (8853040)
1996
34
Interstitial lattice shadow and mediastinal lymphadenopathy with an elevation of carcinoembryonic antigen in severe pulmonary alveolar proteinosis. (1611200)
1992
35
Pulmonary alveolar proteinosis (with review of literature). (3060464)
1988
36
Pulmonary alveolar proteinosis complicated by cerebral abscess: report of a case. (3528083)
1986
37
Inorganic particulates associated with pulmonary alveolar proteinosis: SEM and X-ray microanalysis results. (3036185)
1986
38
Pulmonary alveolar proteinosis in the newborn. (3838881)
1985
39
Pulmonary alveolar proteinosis: prospective clinical experience in 23 patients for 15 years. (6492867)
1984
40
Progressive intrapartum respiratory insufficiency due to pulmonary alveolar proteinosis. Amelioration by therapeutic whole-lung bronchopulmonary lavage. (6468015)
1984
41
The immunoinhibitory activities of the lung lavage materials and sera from patients with pulmonary alveolar proteinosis (PAP). (6894313)
1981
42
Particulate concentrations in pulmonary alveolar proteinosis. (318522)
1978
43
Pulmonary Alveolar proteinosis. Lobar localization and surgical excision. (1262145)
1976
44
Pulmonary alveolar proteinosis--physiologic observations during and after pulmonary lavage. (4531921)
1973
45
Pulmonary alveolar proteinosis. Home treatment with intermittent positive pressure breathing. (4573995)
1973
46
Focal pulmonary alveolar proteinosis in pulmonary tuberculosis. (5766260)
1969
47
Pulmonary alveolar proteinosis. (6071228)
1967
48
Pulmonary alveolar proteinosis. Treatment in a case complicated by tuberculosis. (6066626)
1967
49
Pulmonary alveolar proteinosis presenting with pneumothorax. (6073913)
1967
50
Studies of pulmonary alveolar microlithiasis and pulmonary alveolar proteinosis. (13775542)
1960

Variations for Pulmonary Alveolar Proteinosis

About this section

Expression for genes affiliated with Pulmonary Alveolar Proteinosis

About this section
Search GEO for disease gene expression data for Pulmonary Alveolar Proteinosis.

Pathways for genes affiliated with Pulmonary Alveolar Proteinosis

About this section

Pathways related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CSF1, CSF2
29.6CSF2, SFTPD
39.6CCL2, CSF1
49.2CCL2, CSF1, CSF2
59.2CCL2, CSF1, CSF2
69.1CSF1, CSF2, CSF2RA
78.8CCL2, CSF1, CSF2RB
8
Show member pathways
8.6CSF2, CSF2RA, CSF2RB
9
Show member pathways
8.6CSF2, CSF2RA, CSF2RB
108.6CCL2, CSF2RB, GATA2
11
Show member pathways
8.1CSF2, CSF2RA, CSF2RB, GATA2
12
Show member pathways
7.9CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
13
Show member pathways
7.9CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
14
Show member pathways
7.9CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
15
Show member pathways
7.9CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
16
Show member pathways
7.7CCL2, CSF1, CSF2, CSF2RA, CSF2RB
17
Show member pathways
7.7CCL2, CSF1, CSF2, CSF2RA, CSF2RB
18
Show member pathways
7.4CCL2, CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD

GO Terms for genes affiliated with Pulmonary Alveolar Proteinosis

About this section

Cellular components related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alveolar lamellar bodyGO:009720810.5SFTPB, SFTPC
2multivesicular body lumenGO:009748610.5SFTPB, SFTPC
3lamellar bodyGO:004259910.4SFTPB, SFTPC
4multivesicular bodyGO:000577110.3SFTPB, SFTPC
5clathrin-coated endocytic vesicleGO:004533410.0SFTPB, SFTPC, SFTPD
6endocytic vesicleGO:00301399.7CCL2, SFTPD
7extracellular spaceGO:00056158.0CCL2, CSF1, CSF2, SFTPB, SFTPC, SFTPD
8extracellular regionGO:00055767.5CCL2, CSF2, CSF2RA, SFTPB, SFTPC, SFTPD

Biological processes related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage derived foam cell differentiationGO:001074410.2CSF1, CSF2
2embryonic placenta developmentGO:000189210.1CSF2, GATA2
3positive regulation of macrophage chemotaxisGO:001075910.1CCL2, CSF1
4homeostasis of number of cells within a tissueGO:004887310.1CSF1, GATA2
5macrophage chemotaxisGO:004824610.0CCL2, SFTPD
6positive regulation of phagocytosisGO:005076610.0GATA2, SFTPD
7organ morphogenesisGO:00098879.6CCL2, GATA2, SFTPB
8respiratory gaseous exchangeGO:00075859.0CSF2RB, SFTPB, SFTPC, SFTPD
9activation of MAPKK activityGO:00001868.9CSF2, CSF2RA, CSF2RB
10Ras protein signal transductionGO:00072658.8CSF2, CSF2RA, CSF2RB
11insulin receptor signaling pathwayGO:00082868.8CSF2, CSF2RA, CSF2RB
12cytokine-mediated signaling pathwayGO:00192218.8CCL2, CSF2RA, CSF2RB
13fibroblast growth factor receptor signaling pathwayGO:00085438.8CSF2, CSF2RA, CSF2RB
14Fc-epsilon receptor signaling pathwayGO:00380958.7CSF2, CSF2RA, CSF2RB
15epidermal growth factor receptor signaling pathwayGO:00071738.5CSF2, CSF2RA, CSF2RB
16MAPK cascadeGO:00001658.4CCL2, CSF2, CSF2RA, CSF2RB
17vascular endothelial growth factor receptor signaling pathwayGO:00480108.1CCL2, CSF2, CSF2RA, CSF2RB
18cellular protein metabolic processGO:00442677.8CCL2, CSF2RA, CSF2RB, SFTPB, SFTPC, SFTPD
19innate immune responseGO:00450877.5CSF1, CSF2, CSF2RA, CSF2RB, SFTPD

Molecular functions related to Pulmonary Alveolar Proteinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor bindingGO:00016649.3CCL2, SFTPB
2cytokine receptor activityGO:00048969.0CSF2RA, CSF2RB

Sources for Pulmonary Alveolar Proteinosis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet