Pulmonary Alveolar Proteinosis malady

Wikipedia: Pulmonary alveolar proteinosis (abbreviated PAP), is a rare lung disease in which abnormal accumulation...⁴⁴ more...

MalaCards: Pulmonary Alveolar Proteinosis, also known as pulmonary alveolar proteinosis (disorder), is related to pulmonary surfactant metabolism dysfunction and myelodysplastic syndrome. An important gene associated with Pulmonary Alveolar Proteinosis is SFTPB (surfactant protein B), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Fc epsilon RI signaling pathway. The compounds budesonide and ivig have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lung, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

OMIM: 300770

Aliases & Descriptions:

pulmonary alveolar proteinosis 6 7 8 33 32 43 pulmonary alveolar proteinosis (disorder) 6

Diseases related to pulmonary alveolar proteinosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 623)

id	Related Disease	Score	Top Affiliating Genes
1	pulmonary surfactant metabolism dysfunction	32.9	SFTPB, SFTPC, ABCA3, CSF2RA
2	myelodysplastic syndrome	30.3	VDR, IL3, CSF1, CSF2, CSF3, CSF3R
3	cholesterol	23.3	SFTPB, SFTPC, SFTPD, VDR, MUC1, CEACAM3
4	leukemia	20.3	SFTPD, VDR, MUC1, CEACAM3, MMP9, IL10
5	surfactant deficiency	13.7	SFTPB, SFTPC, ABCA3
6	tonsillitis	13.5	DEFB1, DEFB4A
7	familial eosinophilia	13.5	IL3, IL5
8	chronic myelomonocytic leukemia	13.5	IL3, CSF1, CSF2, GATA2
9	chronic neutrophilic leukemia	13.4	CSF2, CSF3, CSF3R
10	leukemoid reaction	13.4	IL3, CSF2, CSF3
11	lung sarcoma	13.4	SFTPA1, CSF3
12	acute interstitial pneumonia	13.4	SFTPC, SFTPD, CSF3
13	egg allergy	13.4	IL5, IGHE
14	allergic bronchopulmonary aspergillosis	13.4	SFTPD, IL5, IGHE
15	cyclic hematopoiesis	13.4	IL3, CSF1, CSF2, CSF3
16	respiratory failure	13.4	SFTPB, SFTPD, IGHE
17	dyserythropoietic anemia with thrombocytopenia	13.3	IL3, CSF1, CSF2, CSF3
18	intrinsic asthma	13.3	IL3, IL5, IGHE
19	eosinophilic pneumonia	13.3	IL3, IL5, IGHE
20	large cell carcinoma	13.3	CEACAM3, KRT19, CSF2, CSF3
21	pyomyositis	13.3	IGHE, CSF3
22	pancytopenia	13.3	IL3, CSF1, CSF2, CSF3
23	helminthiasis	13.3	IL5, IGHE
24	megakaryocytic leukemia	13.3	IL3, CASP3, CSF2, CSF2RB
25	severe congenital neutropenia	13.3	IL3, CSF2, CSF3
26	myeloproliferative disorder	13.3	IL3, CSF2, CSF3, CSF3R
27	usual interstitial pneumonia	13.2	SFTPC, IL8, CCL2
28	nonspecific interstitial pneumonia	13.2	SFTPC, IL8, CCL2
29	meconium aspiration syndrome	13.2	SFTPB, CCL4, CSF2, CSF3
30	hypereosinophilic syndrome	13.2	IL3, IL5, IGHE, CSF2
31	extrinsic allergic alveolitis	13.2	SFTPD, IL8, CCL2
32	non-small cell lung carcinoma	13.2	SFTPB, SFTPC, SFTPD, CASP3, KRT19
33	lung benign neoplasm	13.2	SFTPB, SFTPC, SFTPD, CASP3, KRT19
34	erdheim-chester disease	13.2	IL1B, CCL4, CCL2
35	idiopathic interstitial pneumonia	13.2	SFTPC, SFTPD, IL8, CCL2
36	pulmonary sarcoidosis	13.2	SFTPD, CCL2, TNF, CSF2
37	aplastic anemia	13.2	IL3, CSF1, CSF2, CSF3, GATA2
38	polycythemia vera	13.2	IL3, CSF2, CSF3, CSF3R
39	polycythemia	13.1	IL3, CSF1, CSF2, CSF3, CSF3R
40	stachybotrys chartarum	13.1	IL1B, IL3, CCL4, CSF1
41	interstitial lung disease	13.1	SFTPB, SFTPC, SFTPD, IL8, CCL2
42	localized scleroderma	13.1	IL8, DEFB1, DEFB4A
43	periapical granuloma	13.1	CCL4, CCL2, TNF
44	cough variant asthma	13.1	IL10, IL5, IGHE
45	ocular cicatricial pemphigoid	13.1	IL5, TNF, CSF1
46	punctate inner choroidopathy	13.1	IL10, TNF
47	urinary schistosomiasis	13.1	IL10, IL5, IGHE
48	obstructive lung disease	13.1	SFTPC, IGHE, TNF
49	coronary artery aneurysm	13.1	CCL2, IGHE, TNF
50	arteriosclerosis	13.0	IL10, CCL2, CSF1, CSF2

Clinical features from OMIM: 300770

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pulmonary alveolar proteinosis:

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MGI Mouse Phenotypes related to pulmonary alveolar proteinosis:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	GATA2
2	respiratory system phenotype	MP:0005388	10.2	CSF2RB, ABCA3, SFTPD, SFTPC
3	liver/biliary system phenotype	MP:0005370	9.9	CYP27A1, SPI1, NR1H3, ABCG1
4	renal/urinary system phenotype	MP:0005367	9.4	GATA2, SLC7A7, ABCG1, ABCA3, CASP3
5	immune system phenotype	MP:0005387	8.9	VDR, SLC7A7, CSF3R, CSF2RB, CSF2, ABCG1
6	behavior/neurological phenotype	MP:0005386	8.5	SLC7A7, CSF2, ABCG1, ABCA3, NR1H3, CCL2
7	skeleton phenotype	MP:0005390	8.5	SLC7A7, CSF2, CSF1, KRT19, SPI1, CASP3
8	integument phenotype	MP:0010771	8.3	SLC7A7, CSF3, CSF2, CSF1, SOAT1, KRT19
9	digestive/alimentary phenotype	MP:0005381	8.3	CASP3, CCL2, MMP9, MUC1, VDR, KRT19
10	hematopoietic system phenotype	MP:0005397	8.2	GATA2, SLC7A7, CSF3R, CSF3, CSF2RB, CSF2
11	mortality/aging	MP:0010768	8.1	ABCA3, DEFB1, CSF1, CSF2, SLC7A7, GATA2
12	growth/size phenotype	MP:0005378	8.0	GATA2, SLC7A7, CSF2, ABCG1, KRT19, SPI1
13	reproductive system phenotype	MP:0005389	7.2	GATA2, SLC7A7, CSF2, CSF1, KRT19, NR1H3
14	tumorigenesis	MP:0002006	6.9	TNF, SPI1, KRT19, SOAT1, CSF2, CCL2
15	vision/eye phenotype	MP:0005391	6.8	TNF, SPI1, SOAT1, CSF1, CASP3, CCL2
16	cardiovascular system phenotype	MP:0005385	6.6	KRT19, ABCA3, SOAT1, CSF1, CSF2, GATA2
17	cellular phenotype	MP:0005384	6.4	ABCG1, SOAT1, CSF1, CSF2, CSF2RB, CSF3R
18	homeostasis/metabolism phenotype	MP:0005376	6.3	NR1H3, ABCA3, ABCG1, SOAT1, CSF1, CSF2

Articles related to pulmonary alveolar proteinosis:

(show top 50)    (show all 51)

id	Title	Authors	Year	Affiliating Genes
1	Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB. (21075760)	Tanaka T.... Morimoto K.	2011	CSF2RB
2	Hereditary pulmonary alveolar proteinosis caused by r ecessive CSF2RB mutations. (21205713)	Suzuki T.... Trapnell B.C.	2011	CSF2RB
3	Lysosomal iron in pulmonary alveolar proteinosis: a case report. (19251804)	Persson H.L.... Vainikka L.K.	2009	CASP3
4	Quantitative analysis of longitudinal response to aerosolized granulocyte-macrophage colony-stimulating factor in two adolescents with autoimmune pulmonary alveolar proteinosis. (19265094)	Robinson T.E.... Cornfield D.N.	2009	CSF2
5	A novel 1,25-dihydroxyvitamin D-activin A pathway in human alveolar macrophages is dysfunctional in patients with pulmonary alveolar proteinosis (PAP). (18803071)	Barna B.P.... Thomassen M.J.	2009	VDR
6	Congenital pulmonary alveolar proteinosis related to a surfactant protein B deficiency: report of two cases (20005435)	Verhasselt-Crinquette M.... Devisme L.	2009	SFTPB
7	Pulmonary alveolar proteinosis: a bench-to-bedside st ory of granulocyte-macrophage colony-stimulating factor dysfunction. (19666756)	Greenhill S.R.... Kotton D.N.	2009	CSF2
8	Clinical importance of bronchoalveolar lavage fluid and blood cytokines, surfactant protein D, and Kerbs von Lungren 6 antigen in idiopathic pulmonary alveolar proteinosis. (19046553)	Lin F.C.... Chang S.C.	2008	TNF, IL1B, IL8
9	A combination therapy of whole lung lavage and GM-CSF inhalation in pulmonary alveolar proteinosis. (18618617)	Yamamoto H.... Nakata K.	2008	CSF2
10	Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. (18202348)	Inoue Y.... Nakata K.	2008	CSF1
11	Differences in the immunolocalization of surfactant protein (SP)-A, SP-D, and KL-6 in pulmonary alveolar proteinosis. (18251786)	Kobayashi M.... Ohtsuki Y.	2008	CSF2, SFTPD, SFTPA1
12	Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. (18955570)	Suzuki T.... Trapnell B.C.	2008	CSF2RA, CSF1
13	Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. (18955567)	Martinez-Moczygemba M.... Huston D.P.	2008	CSF2RA
14	Elevated BALF concentrations of alpha- and beta-defensins in patients with pulmonary alveolar proteinosis. (17000097)	Mukae H.... Kohno S.	2007	DEFB1, DEFB4A
15	ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis. (17848583)	Thomassen M.J.... Febbraio M.	2007	ABCG1, NR1H3
16	GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. (17287477)	Uchida K.... Trapnell B.C.	2007	CSF2
17	Serum antibody against granulocyte/macrophage colony-stimulating factor and KL-6 in idiopathic pulmonary alveolar proteinosis. (16565598)	Nara M.... Hattori T.	2006	CSF1
18	Aerosol granulocyte-macrophage colony-stimulating factor for pulmonary alveolar proteinosis. (16507860)	Wylam M.E.... Anderson P.M.	2006	CSF2
19	Elevated gelatinase activity in pulmonary alveolar proteinosis: role of macrophage-colony stimulating factor. (16275889)	Bonfield T.L.... Thomassen M.J.	2006	MMP9, CSF1
20	Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosis. (15735059)	Tazawa R.... Nukiwa T.	2005	SPI1, CSF2
21	The pulmonary expression of granulocyte-macrophage colony-stimulating factor and surfactant protein in adult idiopathic pulmonary alveolar proteinosis (16316563)	Zhou X.M.... Chen J.	2005	CSF2, SFTPD
22	Elevated monocyte chemotactic proteins 1, 2, and 3 in pulmonary alveolar proteinosis are associated with chemokine receptor suppression. (15596412)	Bonfield T.L.... Thomassen M.J.	2005	CCL2
23	Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis. (15466366)	Meaney S.... Thomassen M.J.	2004	CYP27A1, SOAT1
24	High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. (14512323)	Uchida K.... Keicho N.	2004	CSF2
25	Surfactant proteins in pulmonary alveolar proteinosis in adults. (15358702)	Brasch F.... Johnen G.	2004	SFTPB, SFTPC
26	Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease. (15039969)	Tredano M.... Bahuau M.	2004	SFTPC
27	Autoantibody against granulocyte-macrophage colony-stimulating factor and other serum markers in pulmonary alveolar proteinosis (15730782)	Xu K.F.... Zhu Y.J.	2004	CSF2, CEACAM3
28	Elevated IL-10 inhibits GM-CSF synthesis in pulmonary alveolar proteinosis. (14567558)	Thomassen M.J.... Kavuru M.S.	2003	IL10, CSF2
29	Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome. (12636240)	Ohnishi T.... Abe S.	2003	CSF2
30	Pulmonary alveolar proteinosis in a patient with acute lymphoid leukemia regression after G-CSF therapy. (12802928)	Pamuk G.E.... Cakir B.	2003	CSF3
31	Analysis of the GM-CSF and GM-CSF/IL-3/IL-5 receptor common beta chain in a patient with pulmonary alveolar proteinosis. (11930665)	Wang X.... Bewig B.	2002	CSF2
32	Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis. (12356582)	Bonfield T.L.... Thomassen M.J.	2002	CSF2
33	Change in cytokeratin 19 fragment level according to the severity of pulmonary alveolar proteinosis. (11688827)	Minakata Y.... Yukawa S.	2001	KRT19
34	Expression of GM-CSF in patients with pulmonary alveolar proteinosis (11802999)	Wang X.... Liu F.	2001	CSF2
35	Detection of granulocyte-macrophage colony-stimulating factor in patients with pulmonary alveolar proteinosis. (10764326)	Carraway M.S.... Piantadosi C.A.	2000	TNF, CSF2
36	Exogenous granulocyte-macrophage colony-stimulating factor administration for pulmonary alveolar proteinosis. (10764303)	Kavuru M.S.... Stoller J.K.	2000	CSF2
37	Pulmonary alveolar proteinosis: two contrasting cases. (10706517)	Crocker H.L.... Ruffin R.E.	2000	SFTPB
38	Serological diagnosis of idiopathic pulmonary alveolar proteinosis. (10934102)	Kitamura T.... Nakata K.	2000	CSF2
39	Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. (10499925)	Kitamura T.... Nakata K.	1999	CSF1
40	Elevated bronchoalveolar concentrations of MCP-1 in patients with pulmonary alveolar proteinosis. (10515418)	Iyonaga K.... Ando M.	1999	CCL2
41	Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. (10198353)	Reed J.A.... Whitsett J.A.	1999	CSF2, SFTPB
42	Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony stimulating factor. (9929010)	Tanaka N.... Nakata K.	1999	IL3
43	Attenuated hematopoietic response to granulocyte-macrophage colony-stimulating factor in patients with acquired pulmonary alveolar proteinosis. (9763547)	Seymour J.F.... Dunn A.R.	1998	CSF2
44	Human pulmonary alveolar proteinosis associated with a defect in GM- CSF/IL-3/IL-5 receptor common beta chain expression. (9410898)	Dirksen U.... Burdach S.	1997	CSF2RB
45	The pulmonary alveolar proteinosis in granulocyte macrophage colony-stimulating factor/interleukins 3/5 beta c receptor-deficient mice is reversed by bone marrow transplantation. (8676086)	Nishinakamura R.... Murray R.	1996	CSF2, IL5
46	Elevation of tumour markers in serum and bronchoalveolar lavage fluid in pulmonary alveolar proteinosis. (7656937)	Hirakata Y.... Kitamura S.	1995	CEACAM3
47	Increased carcinoembryonic antigen concentrations in sera and bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis. (8552862)	Fujishima T.... Abe S.	1995	CEACAM3
48	A case of pulmonary alveolar proteinosis with increased IgE and CEA (8189647)	Higuchi M.... Okubo H.	1994	IGHE
49	Accumulation of surfactant protein D in human pulmonary alveolar proteinosis. (8424457)	Crouch E.... Chang D.	1993	SFTPD
50	Interstitial lattice shadow and mediastinal lymphadenopathy with an elevation of carcinoembryonic antigen in severe pulmonary alveolar proteinosis. (1611200)	Usui Y.... Kimula Y.	1992	CEACAM3

Genes related to pulmonary alveolar proteinosis according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	SFTPB	surfactant protein B	11.1	Summaries, Publications
2	SFTPC	surfactant protein C	11.1	Summaries, Publications
3	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
4	SFTPD	surfactant protein D	11.0	Publications
5	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
6	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
7	CSF3R	colony stimulating factor 3 receptor (granulocyte)	11.0
8	KRT19	keratin 19	11.0	Publications
9	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
10	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
11	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	11.0	Publications
12	CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	11.0	Publications
13	CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	11.0	Publications
14	GATA2	GATA binding protein 2	11.0
15	SFTPA1	surfactant protein A1	11.0	Publications
16	DEFB1	defensin, beta 1	11.0	Publications
17	NR1H3	nuclear receptor subfamily 1, group H, member 3	11.0	Publications
18	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	11.0	Publications
19	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications
20	DEFB4A	defensin, beta 4A	11.0	Publications
21	ABCA3	ATP-binding cassette, sub-family A (ABC1), member 3	11.0
22	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	11.0
23	SOAT1	sterol O-acyltransferase 1	11.0	Publications
24	ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	11.0	Publications
25	CCL4	chemokine (C-C motif) ligand 4	11.0	Publications
26	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
27	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
28	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
29	IL1B	interleukin 1, beta	11.0	Publications
30	IL8	interleukin 8	11.0	Publications
31	IL10	interleukin 10	11.0	Publications
32	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
33	MUC1	mucin 1, cell surface associated	11.0
34	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
35	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
36	TNF	tumor necrosis factor	11.0	Publications

Pathways related to pulmonary alveolar proteinosis according to GeneDecks:

(show top 50)    (show all 52)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	CCL4, CSF2
2	Fc epsilon RI signaling pathway20	10.1	TNF
3	Selected targets of C/EBPalpha10	10.1	SFTPD, CSF2RA, CSF3R
4	Regulation of eIF4 and p70S6K36	10.1	IL3, IL5, CCL4
5	NFAT Signaling and Lymphocyte Interactions36	10.0	CCL2, CCL4, IL5, IL3
6	Bacterial infections in CF airways41	9.9	DEFB4A, MUC1, SFTPD, SFTPA1
7	Molecular Mechanisms of Cancer36	9.7	CSF2RB, CSF2RA, CASP3, IL5, IL3
8	LDL Oxidation in Atherogenesis36	9.7	CSF1, TNF, CCL2, IL1B
9	MSP-RON Signaling36	9.5	CSF2RB, CSF1, TNF, CCL2, IL1B
10	Immune System38	9.5	CSF2RB, CSF2RA, CSF2, DEFB4A, DEFB1, IL5
11	RAR-Gamma-RXR-Alpha Degradation36	9.4	CSF3, CSF2, CSF1, CCL4, IL3
12	Asthma20	9.4	TNF, IL5, IL3, IL10
13	NOD-like receptor signaling pathway20	9.3	TNF, CCL2, IL8, IL1B
14	Immune response_MIF in innate immunity response41	9.3	SPI1, TNF, IL8, IL1B
15	PGC1Alpha Pathway36	9.3	CSF2RB, CCL4, IL8, IL5, IL3, IL1B
16	Immune response MIF in innate immunity response10	9.3	SPI1, TNF, IL8, IL1B
17	Rheumatoid arthritis20	9.2	CSF2, CSF1, TNF, CCL2, IL8, IL1B
18	Apoptosis20	9.1	CSF2RB, TNF, CASP3, IL3, IL1B
19	T cell receptor signaling pathway20	9.1	IL10, IL5, TNF, CSF2
20	Pathways in cancer20	9.0	CSF3R, CSF2RA, SPI1, CASP3, MMP9
21	Chagas disease (American trypanosomiasis)20	8.9	TNF, CCL2, IL8, IL1B, IL10
22	IL-10 Pathway36	8.9	IL10, IL1B, TNF
23	Akt Signaling36	8.9	CSF3R, CSF2RB, CSF2RA, CSF2, CSF1, TNF
24	Toll-like receptor signaling pathway20	8.9	TNF, CCL4, IL8, IL1B
25	SOCS Pathway36	8.8	CCL2, CCL4, IL8, IL5, IL3, IL1B
26	ERK Signaling36	8.8	CSF3, IL5, IL3, IL1B, IL10
27	Cytokine Network36	8.8	TNF, IL8, IL5, IL3, IL1B, IL10
28	Glucocorticoid Receptor Signaling36	8.7	CSF2RB, CCL2, CCL4, IL8, IL5, IL3
29	TGF-Beta Pathway36	8.7	CSF2RB, CCL2, CCL4, IL8, IL5, IL3
30	Jak-STAT signaling pathway20	8.6	CSF3R, CSF3, CSF2RB, CSF2RA, CSF2, IL5
31	JAK-STAT Pathway36	8.6	CSF2RB, CCL2, CCL4, IL8, IL5, IL3
32	Tuberculosis20	8.6	TNF, CASP3, IL1B, IL10, VDR
33	Amoebiasis20	8.6	CSF2, TNF, CASP3, IL8, IL1B, IL10
34	Pertussis20	8.6	TNF, CASP3, IL8, IL1B, IL10, SFTPA1
35	Endothelin-1 Signaling Pathway36	8.3	IL10, IL1B, IL3, IL5, CASP3, CSF1
36	Malaria20	8.2	CSF3, TNF, CCL2, IL8, IL1B, IL10
37	Hematopoietic cell lineage20	8.2	CSF3R, CSF3, CSF2RA, CSF2, CSF1, TNF
38	MAPK Family Pathway36	8.2	CSF2RB, TNF, CCL2, CCL4, IL8, IL5
39	Tec Kinases Signaling36	7.9	CSF3R, CSF2RB, CSF2RA, TNF, CCL2, CCL4
40	MIF Regulation of Innate Immune Cells36	7.3	CSF3, CSF2, CSF1, TNF, CCL2, CCL4
41	MIF Mediated Glucocorticoid Regulation36	7.3	IL5, IL3, IL1B, IL10, IL8, CCL4
42	PEDF Induced Signaling36	7.3	IL1B, IL3, IL5, IL8, CCL4, CCL2
43	all-trans-Retinoic Acid Signaling in Brain36	7.3	CSF3, IL10, IL1B, IL3, IL5, IL8
44	IL-6 Pathway36	7.3	CSF3, CSF2, CSF1, TNF, CCL2, CCL4
45	Rho Family GTPases36	7.3	CSF3, CSF2, CSF1, TNF, CCL2, CCL4
46	STAT3 Pathway36	6.9	CSF3R, CSF3, CSF2RB, CSF2RA, CSF2, CSF1
47	Antioxidant Action of Vitamin-C36	6.9	CSF3, CSF3R, CSF2RB, CSF2RA, CSF2, IL10
48	PAK Pathway36	6.8	CASP3, TNF, CSF1, CSF2, CSF3, CCL2
49	Cytokine-cytokine receptor interaction20	6.7	IL10, IL1B, IL3, CSF3R, CSF3, CSF2RB
50	p38 Signaling36	6.4	IL10, CSF3R, CSF3, CSF2RB, CSF2RA, CSF2

Compounds related to pulmonary alveolar proteinosis according to GeneDecks:

(show top 50)    (show all 235)

id	Compound	Score	Top Affiliating Genes
1	budesonide32 42 9 9	13.3	CSF2, SFTPD, IGHE
2	ivig32	10.3	IL3, CCL4, CSF1, CSF2
3	pge232	10.1	SFTPB, IL5, CCL4
4	methylcellulose32	9.8	IL5, CSF1, GATA2, CSF3R, IL3, CSF2
5	n-formylmethionyl-leucylphenylalanine32	9.6	CSF1, IL3, CSF2, CSF3
6	nedocromil sodium32	9.4	IL8, IL5, IGHE, CSF1, IL3
7	endotoxin32	9.2	SFTPD, CCL4, DEFB4A, CXCR1, CSF3, CSF3R
8	histamine32 18	10.1	CCL2, IL5, IL3, IGHE, DEFB4A, CSF1
9	toxin-132	8.8	CCL4, IL1B, CCL2, TNF, IL10, IL8
10	polymyxin b32	8.8	TNF, IL8, DEFB1, IL10, IL1B, CCL2
11	sb 20358032 42	9.7	VDR, CCL4, CASP3, TNF, MMP9
12	neopterin32	8.7	IL10, CSF2, IL1B, CSF1, TNF, IL8
13	oxygen32 18	9.7	SFTPC, CEACAM3, CSF3R, CCL4, CYP27A1, CASP3
14	il-1232	8.6	IL1B, IL5, IL8, CCL2, TNF, CSF2
15	mip 1alpha32	8.6	CSF2, IL10, IL1B, IL3, IL8, CCL4
16	groalpha32	8.5	CCL2, IL8, TNF, CCL4, CSF2, CXCR1
17	triptolide32	8.4	IL1B, TNF, CASP3, CCL2, CCL4, IL8
18	15-deoxy-delta-12,14-prostaglandin j232	8.3	CSF2, CASP3, IL10, IL1B, CCL2, TNF
19	tarc32	8.2	CSF2, CXCR1, TNF, IGHE, CCL2, IL10
20	fluticasone propionate32 42 9 9	11.1	IL8, IGHE, IL5, CSF2, CSF1, TNF
21	herbimycin a32 42	9.0	CXCR1, IL8, CCL2, IL5, CSF2, MMP9
22	leukotriene b432 42 18	10.0	CSF2, TNF, MMP9, CSF1, IL5, IL3
23	imatinib32 34 9 9	10.9	CSF3, ABCA3, CSF3R, IL10, IL3, IL5
24	prednisolone32 9 9	9.9	CCL4, CSF1, TNF, IGHE, IL5, IL10
25	il 1032	7.8	CSF1, TNF, CCL2, CCL4, IL8, IL5
26	5fluorouracil32	7.8	CCL2, CSF3, CSF2, CSF1, CASP3, IL3
27	troglitazone32 42 9 9	10.8	CSF1, CASP3, CCL2, IL8, IL1B, VDR
28	rantes32	7.8	DEFB4A, CXCR1, CSF1, CSF2, CSF3, DEFB1
29	hydrocortisone32 9 9	9.8	IL10, MUC1, IL1B, IL8, CSF2, TNF
30	ciglitazone32	7.7	MMP9, TNF, IL1B, IL8, CCL2, CASP3
31	cysteine32	7.7	SFTPC, SFTPB, CSF2, MUC1, CASP3, SOAT1
32	fmlp32	7.6	IL5, IL8, TNF, IL3, CSF2, CSF3
33	gm-csf32	7.6	IL10, IL1B, IL3, IL5, IL8, CCL2
34	lactate32	7.6	TNF, KRT19, CASP3, IGHE, IL8, IL3
35	simvastatin32 34 42 9 18 9	12.5	TNF, CASP3, CCL2, CYP27A1, CCL4, IL8
36	n acetylcysteine32	7.5	MMP9, SOAT1, CASP3, IGHE, CCL2, CSF1
37	pd 98,05932	7.3	CSF2, CCL4, CSF1, SOAT1, DEFB4A, IL8
38	ccl332	7.2	CCL2, MMP9, IL1B, IL10, IL8, TNF
39	vegf32	7.1	CSF1, CXCR1, KRT19, CCL2, CCL4, IL1B
40	butyrate32	7.1	GATA2, IL5, VDR, MUC1, MMP9, IL3
41	genistein32 9 18 9	9.9	VDR, CCL2, MMP9, IL1B, CSF2, CSF1
42	superoxide32 18	7.9	IL8, CSF3R, CSF3, CSF2, CSF1, CXCR1
43	methotrexate32 34 42 9 9	10.7	TNF, MMP9, IL10, MUC1, IL5, CSF3
44	thymidine32 18	7.7	VDR, SFTPD, SFTPB, MUC1, CEACAM3, IL10
45	actinomycin d32	6.3	IL3, CSF1, CSF2, SOAT1, CXCR1, TNF
46	cyclosporin a32 42	7.1	TNF, CASP3, IGHE, CCL4, IL5, VDR
47	serine32	5.9	CSF1, CSF2RA, SOAT1, CSF3R, MUC1, VDR
48	cycloheximide32	4.5	SFTPB, GATA2, KRT19, TNF, CASP3, IGHE
49	retinoic acid32 42 18	6.0	GATA2, CYP27A1, IL3, IL1B, MMP9, MUC1
50	dexamethasone32 42 34 9 9	7.9	CSF1, CSF2, CSF3, CSF3R, CCL2, SFTPB

Cellular components related to pulmonary alveolar proteinosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	6.7	CCL4, CCL2, DEFB1, DEFB4A, CSF2, CSF2RA
2	extracellular space	GO:005615	5.4	SFTPA1, CSF3, CSF2, CSF1, TNF, CCL2

Biological processes related to pulmonary alveolar proteinosis according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	respiratory gaseous exchange	GO:007585	10.2	CSF2RB, SFTPD, SFTPC, SFTPB, SFTPA1
2	response to hyperoxia	GO:055093	9.9	MMP9, SFTPC, SFTPB
3	anatomical structure regression	GO:060033	9.9	SPI1, MMP9
4	positive regulation of podosome assembly	GO:071803	9.9	IL5, TNF, CSF2
5	macrophage differentiation	GO:030225	9.9	MMP9, SPI1, CSF1
6	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.8	TNF, IL1B
7	neutrophil chemotaxis	GO:030593	9.8	CSF3R, CCL2, IL8, IL1B
8	chemotaxis	GO:006935	9.8	CXCR1, DEFB4A, DEFB1, CCL2, CCL4
9	sequestering of triglyceride	GO:030730	9.8	TNF, IL1B
10	chronic inflammatory response to antigenic stimulus	GO:002439	9.7	TNF, IL1B
11	receptor biosynthetic process	GO:032800	9.7	TNF, IL10
12	protein kinase B signaling cascade	GO:043491	9.7	IL1B, CCL2, TNF
13	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	TNF, CCL2, IL1B
14	organ morphogenesis	GO:009887	9.7	TNF, CCL2, VDR, SFTPB
15	cellular response to lipopolysaccharide	GO:071222	9.7	NR1H3, CCL2, IL8, IL10
16	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.6	IL1B, TNF
17	response to activity	GO:014823	9.4	TNF, CCL2, IL10
18	cellular response to interleukin-1	GO:071347	9.2	MMP9, IL8, CCL2
19	response to glucocorticoid stimulus	GO:051384	9.2	TNF, CCL2, IL1B, IL10, SFTPC, SFTPB
20	cellular response to organic cyclic compound	GO:071407	9.2	IL1B, CCL2, TNF
21	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.2	TNF, IL5, IL1B, IL10
22	response to hypoxia	GO:001666	9.0	SFTPB, MMP9, IL1B, CCL2, TNF
23	anti-apoptosis	GO:006916	8.6	TNF, CCL2, IL1B, IL10, MUC1
24	inflammatory response	GO:006954	8.1	IL10, CSF1, CXCR1, TNF, CCL2, CCL4
25	immune response	GO:006955	8.1	CSF3, CSF2, DEFB4A, DEFB1, IGHE, CCL4

Molecular functions related to pulmonary alveolar proteinosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol binding	GO:015485	9.8	NR1H3, ABCG1, SOAT1
2	growth factor activity	GO:008083	7.9	CSF3, CSF2, CSF1, IL5, IL3, IL1B
3	cytokine activity	GO:005125	7.3	IL10, CSF3, CSF2, CSF1, TNF, CCL4