MCID: PLM006
MIFTS: 56

Pulmonary Alveolar Proteinosis malady

Summaries for Pulmonary Alveolar Proteinosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange.

MalaCards: Pulmonary Alveolar Proteinosis is related to leukemia and pneumonia. An important gene associated with Pulmonary Alveolar Proteinosis is SFTPB (surfactant protein B), and among its related pathways are Rheumatoid arthritis and B cell receptor signaling pathway. The compounds cycloheximide and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include lung, myeloid and bone marrow, and related mouse phenotypes are respiratory system and skeleton.

Wikipedia:63 Pulmonary alveolar proteinosis (abbreviated PAP), is a rare lung disease in which abnormal accumulation... more...

Aliases & Classifications for Pulmonary Alveolar Proteinosis

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

pulmonary alveolar proteinosis 8 22 10 44 60


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Disease Ontology8 DOID:12120
NCIt39 C85037
SNOMED-CT56 10501004
MeSH34 D011649
ICD9CM27 516.0

Related Diseases for Pulmonary Alveolar Proteinosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pulmonary Alveolar Proteinosis family:

Congenital Pulmonary Alveolar Proteinosis Pulmonary Alveolar Proteinosis Acquired

Diseases related to Pulmonary Alveolar Proteinosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.1CCL4, CSF3R, CSF2RA, CSF2, CSF1, TNF
2pneumonia31.0IL1B, IL8, IL10, DEFB1, TNF, CSF2
3pulmonary fibrosis30.8SFTPC, CCL2, CCL4, SFTPD, IL8, IL1B
4pulmonary tuberculosis30.8CCL4, CXCR1, IL10
5tuberculosis30.8CCL4, SFTPD, TNF, CXCR1, IL10, IL1B
6acute leukemia30.7CSF3R, CSF2, CSF1, CXCR1, IL3
7lung cancer30.7CEACAM3, KRT19, SFTPB, SFTPC
8respiratory failure30.6SFTPD, SFTPB
9myeloid leukemia30.5IL3, CSF1, CSF2, CSF3R
10arthritis30.5TNF, IL8, IL1B
11idiopathic pulmonary fibrosis30.5IL1B, IL8, CXCR1, SFTPB, SFTPD, SFTPC
12psoriasis30.5CCL4, CCL2, TNF, CXCR1, IL10, IL8
13squamous cell carcinoma30.5SFTPB, CSF3R, DEFB1, CXCR1, KRT19, CEACAM3
14bronchiectasis30.3IL8
15aspergillosis30.3CSF1, SFTPD
16pulmonary eosinophilia30.3SFTPD, IL8
17malignant mesothelioma30.3CEACAM3, SFTPB
18acquired immunodeficiency syndrome30.3IL1B, CSF2
19deficiency anemia30.3CSF3R, CSF2, IL3
20glomerulonephritis30.3IL1B, CCL2, CCL4
21meningitis30.3IL1B, IL8, CCL4
22eosinophilia30.3CSF2, CSF1, IL3, IL10, IL8
23myeloma30.3CCL4, CSF2, CSF1, IL3, IL1B
24chronic myeloid leukemia30.3CSF3R, CSF2RA, CSF2, IL3
25systemic lupus erythematosus30.3IL10, TNF, CCL2, CCL4
26melanoma30.3CCL4, CSF3R, CSF2, CSF1, TNF, CXCR1
27congenital pulmonary alveolar proteinosis10.7
28idiopathic pulmonary alveolar proteinosis10.6
29lysinuric protein intolerance10.5
30pulmonary alveolar proteinosis acquired10.5
31lipoid proteinosis10.4
32desquamative interstitial pneumonia10.3
33fanconi's anemia10.3
34cryptococcosis10.3
35amyloidosis10.3
36lung squamous cell carcinoma10.3
37mediastinitis10.3
38pneumothorax10.3
39surfactant metabolism dysfunction, pulmonary, 110.3
40surfactant metabolism dysfunction, pulmonary, 510.3
41lymphoid leukemia10.2
42niemann-pick disease10.2
43congenital dyserythropoietic anemia10.2
44pulmonary aspergilloma10.2
45lipid pneumonia10.2
46lymphangioleiomyomatosis10.2
47cerebritis10.2
48acute myeloid leukemia10.2
49common variable immunodeficiency10.2
50pulmonary alveolar microlithiasis10.2

Graphical network of the top 20 diseases related to Pulmonary Alveolar Proteinosis:



Diseases related to pulmonary alveolar proteinosis

Clinical Features for Pulmonary Alveolar Proteinosis

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Drugs & Therapeutics for Pulmonary Alveolar Proteinosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Alveolar Proteinosis

Drug clinical trials:

Search ClinicalTrials for Pulmonary Alveolar Proteinosis

Search NIH Clinical Center for Pulmonary Alveolar Proteinosis

Search CenterWatch for Pulmonary Alveolar Proteinosis

Genetic Tests for Pulmonary Alveolar Proteinosis

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22GTR
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Genetic tests related to Pulmonary Alveolar Proteinosis:

id Genetic test Affiliating Genes
1 Pulmonary Alveolar Proteinosis22

Anatomical Context for Pulmonary Alveolar Proteinosis

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32MalaCards
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MalaCards organs/tissues related to Pulmonary Alveolar Proteinosis:

32
Lung, Myeloid, Bone marrow, Bone, Monocytes, Brain, Heart, Testes, T cells

Animal Models for Pulmonary Alveolar Proteinosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pulmonary Alveolar Proteinosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.1SFTPC, SFTPD, SFTPB, CSF2RB
2MP:00053909.9KRT19, IL1B, CSF1, CSF2
3MP:00053769.8CCL2, CSF2RB, CSF1, IL3
4MP:00020069.7CCL2, SFTPC, TNF, IL10, IL1B, KRT19
5MP:00053979.2CCL2, SFTPD, CSF3R, CSF2, CSF2RB, CSF1
6MP:00053859.1CCL2, SFTPC, CSF2, CSF1, TNF, IL10
7MP:00053878.9IL1B, CCL2, SFTPC, SFTPD, CSF3R, CSF2
8MP:00107688.8CSF2, SFTPB, SFTPD, SFTPC, CCL2, CSF1

Publications for Pulmonary Alveolar Proteinosis

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50PubMed
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Articles related to Pulmonary Alveolar Proteinosis:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
De novo complex X chromosome rearrangement unmasking maternally inherited CSF2RA deletion in a girl with pulmonary alveolar proteinosis. (23918747)
2013
2
Standardized serum GM-CSF autoantibody testing for the routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis. (24275678)
2013
3
Lung Squamous Cell Carcinoma in Pulmonary Alveolar Proteinosis. (24200658)
2013
4
Pulmonary alveolar proteinosis: report of two cases in the West of Ireland with review of current literature. (23749726)
2013
5
Congenital pulmonary alveolar proteinosis. (23710403)
2013
6
Pulmonary alveolar proteinosis as a reaction to fentanyl patch smoke. (22553265)
2012
7
Elemental analysis of lung tissue particles and intracellular iron content of alveolar macrophages in pulmonary alveolar proteinosis. (21718529)
2011
8
Pulmonary alveolar proteinosis and successful therapy with combined lavage procedures: Case reports. (22977542)
2011
9
A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: a case report. (21038791)
2010
10
Therapeutic effectiveness of rituximab in a patient with unresponsive autoimmune pulmonary alveolar proteinosis. (20855439)
2010
11
Clinical features and outcomes of idiopathic pulmonary alveolar proteinosis in Korean population. (20191038)
2010
12
Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. (20167854)
2010
13
Pulmonary alveolar proteinosis versus exogenous lipoid pneumonia showing crazy-paving pattern: Comparison of their clinical features and high-resolution CT findings. (20222804)
2010
14
Clinical importance of bronchoalveolar lavage fluid and blood cytokines, surfactant protein D, and Kerbs von Lungren 6 antigen in idiopathic pulmonary alveolar proteinosis. (19046553)
2008
15
Anaesthesia for serial whole-lung lavage in a patient with severe pulmonary alveolar proteinosis: a case report. (19038019)
2008
16
Immunohistochemical localisation of surfactant proteins A and D, and KL-6 in pulmonary alveolar proteinosis. (18604747)
2008
17
Lung cancer may develop subsequently or coincidently with pulmonary alveolar proteinosis. (17566600)
2007
18
Bilateral whole lung lavage in the treatment of pulmonary alveolar proteinosis. (17242125)
2007
19
Pulmonary alveolar proteinosis with myeloproliferative syndrome with myelodysplasia: bronchoalveolar lavage reduces white blood cell count. (16906593)
2006
20
Aerosol granulocyte-macrophage colony-stimulating factor for pulmonary alveolar proteinosis. (16507860)
2006
21
Extra-pulmonary aspects of acquired pulmonary alveolar proteinosis as predicted by granulocyte-macrophage colony-stimulating factor-deficient mice. (16423263)
2006
22
Pulmonary alveolar proteinosis complicating acute myeloid leukaemia. (16173954)
2005
23
Unusual thoracic problems in patients with malignancies: case 2. Malignant mesothelioma in a patient with long-standing pulmonary alveolar proteinosis. (15838000)
2005
24
Pulmonary alveolar proteinosis. What is the role of GM-CSF in disease pathogenesis and treatment? (15350161)
2004
25
Pulmonary alveolar proteinosis treated with whole-lung lavage utilizing extracorporeal membrane oxygenation: a case report and review of literatures. (15569500)
2004
26
Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease. (15039969)
2004
27
Proteomic analysis of human bronchoalveolar lavage fluid: expression profiling of surfactant-associated protein A isomers derived from human pulmonary alveolar proteinosis using immunoaffinity detection. (12548638)
2003
28
Pulmonary alveolar proteinosis. (14753379)
2003
29
Human parainfluenza virus giant cell pneumonia following cord blood transplant associated with pulmonary alveolar proteinosis. (12562244)
2003
30
Usefulness of the modified lavage technique of Bingisser and KL-6 monitoring in a patient with pulmonary alveolar proteinosis. (12058888)
2002
31
Pulmonary alveolar proteinosis: progress in the first 44 years. (12119235)
2002
32
Pulmonary alveolar proteinosis: a spectrum of cytologic, histochemical, and ultrastructural findings in bronchoalveolar lavage fluid. (11391819)
2001
33
Primary pulmonary alveolar proteinosis: a case report and a review of the literature. (17322678)
2000
34
Elevated bronchoalveolar concentrations of MCP-1 in patients with pulmonary alveolar proteinosis. (10515418)
1999
35
Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. (10198353)
1999
36
Lack of GM-CSF as a cause of pulmonary alveolar proteinosis. (8609211)
1996
37
Case of pulmonary alveolar proteinosis treated by sequential whole-lung lavages and a review of the condition. (7574430)
1995
38
Pulmonary alveolar proteinosis as a component of massive fibrosis in cases of chronic pneumoconiosis. An autopsy study of 79 cases. (1801911)
1991
39
Pulmonary alveolar proteinosis: determination of prostaglandins and leukotrienes in lavage fluid. (3031390)
1987
40
A macrophage-suppressing 40-kD protein in a case of pulmonary alveolar proteinosis. (3323640)
1987
41
Pulmonary alveolar proteinosis complicated by cerebral abscess: report of a case. (3528083)
1986
42
Pulmonary alveolar proteinosis: prospective clinical experience in 23 patients for 15 years. (6492867)
1984
43
Glycosaminoglycans and glycoproteins in bronchoalveolar lavage fluid from patients with pulmonary alveolar proteinosis. (6654474)
1983
44
Pulmonary alveolar proteinosis. Staining for surfactant apoprotein in alveolar proteinosis and in conditions simulating it. (6336692)
1983
45
Pulmonary alveolar proteinosis in Jamaica. (7179933)
1982
46
Pulmonary alveolar proteinosis in two siblings with decreased immunoglobulin A. (7435514)
1980
47
Pulmonary alveolar proteinosis and histoplasmosis: report of three cases. (813367)
1975
48
On the origin of the membranous intraalveolar material in pulmonary alveolar proteinosis. (4479251)
1974
49
Pulmonary alveolar proteinosis. Treatment by massive bronchopulmonary lavage. (6017123)
1967
50
Pulmonary alveolar proteinosis. Diagnostic and pathologic implications of pulmonary washings. (5910045)
1966

Genetic Variations for Pulmonary Alveolar Proteinosis

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Expression for genes affiliated with Pulmonary Alveolar Proteinosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Alveolar Proteinosis

Search GEO for disease gene expression data for Pulmonary Alveolar Proteinosis.

Pathways for genes affiliated with Pulmonary Alveolar Proteinosis

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN
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Pathways related to Pulmonary Alveolar Proteinosis according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4CSF2
2
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10.4CSF2
3
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10.2IL8, CCL2
410.1CSF2RA, CSF3R, SFTPD
510.0IL1B, TNF, CCL2
610.0CCL2, TNF, IL1B
7
Hide members
10.0TNF, IL10, IL1B
810.0TNF, IL10, IL1B
910.0TNF, IL10, IL1B
1010.0TNF, IL8, IL1B
11
Hide members
10.0CSF2RB, CCL2, CCL4
12
Hide members
9.9IL8, IL3, TNF, CSF2
139.9CCL2, CSF1, TNF, IL1B
14
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9.9TNF, IL3, IL10, IL1B
15
Development PDGF signaling via STATs and NF-kB
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9.9CCL2, TNF, IL10, IL1B
16
Hide members
9.9CCL2, TNF, IL8, IL1B
179.9IL1B, IL8, IL10, TNF
18
Hide members
9.9CSF2RB, TNF, IL3, IL1B
19
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9.9CCL4, CCL2, CXCR1, IL8
209.9CCL4, CCL2, CXCR1, IL8
219.9CCL4, CSF2, IL8, IL1B
22
Hide members
9.9CCL4, CSF2, TNF, IL10
239.8IL1B, IL8, TNF, CCL4
249.8CCL2, CSF2, CSF1, TNF, IL1B
25
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9.8CSF3R, CSF2RA, CSF2, CSF2RB, CSF1
269.8CSF2, TNF, IL10, IL8, IL1B
279.8TNF, IL3, IL10, IL8, IL1B
28
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9.8CSF2RA, CSF2, CSF2RB, IL3, IL1B
29
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9.8CSF2RA, CSF2, CSF2RB, IL3, IL1B
309.8CCL2, CSF2RB, CSF1, TNF, IL1B
31
Immune response Bacterial infections in normal airways
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9.7SFTPA1, SFTPD, TNF, IL8, IL1B
329.7SFTPA1, TNF, IL10, IL8, IL1B
339.6CSF3R, CSF2RA, CSF2, CSF2RB, IL3, IL10
34
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9.6IL1B, IL3, DEFB1, CSF2RB, CSF2, CSF2RA
35
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9.6CCL4, CCL2, TNF, IL10, IL8, IL1B
36
Hide members
9.5IL3, CSF3R, CSF2RA, CSF2, CSF2RB, CSF1
379.5CSF3R, CSF2RA, CSF2, CSF1, TNF, IL3
38
Hide members
9.5IL3, CSF1, CSF2RB, CSF2, CSF2RA, CSF3R
39
Hide members
8.7TNF, CSF1, CSF2RB, CSF2, CSF2RA, CSF3R

Compounds for genes affiliated with Pulmonary Alveolar Proteinosis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Pulmonary Alveolar Proteinosis according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8SFTPB
2endotoxin4410.8CSF3R
3pge24410.7CSF2
4hydrocortisone44 2 59 1113.5IL8
5gm-csf44 2811.5TNF, CSF2RA, IL10
6fmlp4410.4IL3, CSF3R, CSF1, CSF2
7ivig4410.3CCL4, CSF2, CSF1, IL3
8survanta4410.3IL1B, IL8, SFTPB, SFTPC
9anaphylatoxin4410.3CSF2, IL3, IL8, IL1B
10dexamethasone44 49 28 1113.2SFTPC, SFTPD, SFTPB, DEFB1, CXCR1, IL3
11mdms4410.2CSF2, CSF1, CCL4, CCL2, IL10
12grogamma4410.1CCL4, CCL2, CXCR1, IL8
135 aminosalicylic acid4410.1CCL2, TNF, IL10, IL8, IL1B
14sulfasalazine44 28 49 1113.1TNF, IL8, IL1B, CSF1, CCL2
15pentoxifylline44 1111.1CSF2
16budesonide44 49 1112.1IL1B, CSF2, IL8, SFTPD, TNF, CSF1
17fluticasone propionate44 49 59 1113.1CSF2, IL1B, IL8, CSF1, TNF
18il-124410.0IL8, CCL2, TNF, IL10, CSF2, IL1B
19lipoteichoic acid4410.0IL8, CCL2, TNF, IL10, IL1B
20triptolide4410.0CCL4, CCL2, TNF, IL8, IL1B
21polyinosinic-polycytidylic acid4410.0IL1B, IL8, TNF, CSF1, IL10
22toxin-14410.0TNF, IL10, IL1B, IL8, CCL2, CCL4
23etanercept44 49 1112.0TNF, IL1B, IL8, IL10, CSF1
24polymyxin b4410.0IL8, CCL2, TNF, IL10, DEFB1, IL1B
2515-deoxy-delta-12,14-prostaglandin j24410.0CCL2, CSF2, TNF, IL10, IL8, IL1B
26superoxide44 2410.9IL1B, CCL4, CCL2, CSF3R, CSF2, TNF
27mcp 1449.9IL10, CCL2, CCL4, IL8
28poly(i-c)449.9CSF2, IL8, IL1B, IL3, TNF
29rantes449.9CCL4, CSF2, CSF1, TNF, CXCR1, IL1B
30neopterin449.9IL1B, CSF2, CSF1, IL8, IL10, IL3
31tarc449.9CCL2, CSF2, TNF, CXCR1, IL10, CCL4
32herbimycin a44 5910.9CCL2, IL1B, IL8, IL3, CXCR1, TNF
33ccl344 2810.8CCL4, IL1B, CCL2, TNF, IL10, IL8
34leukotriene b444 59 2411.8TNF, CCL2, IL1B, IL8, IL3, CXCR1
35mip 1alpha449.8IL1B, IL8, IL10, CCL4, CSF2, TNF
36groalpha449.8CSF2, CCL2, TNF, CXCR1, IL10, CCL4
37n-formylmethionyl-leucylphenylalanine449.7IL3, TNF, CSF2, CSF1, IL8
38peptidoglycan44 2810.7IL1B, IL8, IL10, TNF, CCL4
39pd 98,059449.7TNF, CCL4, IL1B, IL8, IL3, CSF1
40genistein44 28 59 2 11 2414.6CSF2, IL8, CCL2, CSF3R, CXCR1, CSF1
41il 10449.6CCL4, CCL2, CSF2, CSF1, TNF, IL3
42oxygen44 2410.6CEACAM3, IL8, CXCR1, TNF, SFTPB, SFTPD
43actinomycin d449.6SFTPB, SFTPC, CCL2, CXCR1, CSF2, CSF1
44sb 20358044 5910.6IL10, CCL2, CCL4, TNF, IL8, IL1B
45histamine44 28 2411.5IL1B, IL8, IL10, IL3, TNF, CSF1
46lactate449.5KRT19, TNF, CEACAM3, CSF2, SFTPD, CSF1
47thymidine44 2410.4KRT19, IL10, IL3, CSF1, CSF2, CEACAM3
48nitric oxide44 11 2411.2IL1B, CCL4, SFTPB, IL8, IL10, TNF
49retinoic acid44 2410.1CSF1, IL1B, IL3, CXCR1, TNF, CSF2
50vegf448.9CSF1, CCL2, SFTPC, SFTPB, CSF3R, CSF2

GO Terms for genes affiliated with Pulmonary Alveolar Proteinosis

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16Gene Ontology
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Cellular components related to Pulmonary Alveolar Proteinosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.7CCL2, SFTPA1, SFTPD, CSF3R, CSF2RA, CSF2
2extracellular spaceGO:0056158.4IL1B, CCL4, CCL2, SFTPA1, SFTPC, SFTPD

Biological processes related to Pulmonary Alveolar Proteinosis according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:06055910.5TNF, IL1B
2receptor biosynthetic processGO:03280010.5TNF, IL10
3sequestering of triglycerideGO:03073010.5TNF, IL1B
4positive regulation of heterotypic cell-cell adhesionGO:03411610.4TNF, IL1B
5negative regulation of cytokine secretion involved in immune responseGO:00274010.4IL10, TNF
6positive regulation of podosome assemblyGO:07180310.4CSF2, TNF
7positive regulation of fever generationGO:03162210.4IL1B, TNF
8negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.4CSF2, TNF, IL1B
9response to activityGO:01482310.4IL10, TNF, CCL2
10lipopolysaccharide-mediated signaling pathwayGO:03166310.4CCL2, TNF, IL1B
11cellular response to organic cyclic compoundGO:07140710.4IL1B, TNF, CCL2
12protein kinase B signaling cascadeGO:04349110.4IL1B, TNF, CCL2
13positive regulation of chemokine biosynthetic processGO:04508010.3TNF, IL1B
14response to molecule of bacterial originGO:00223710.3IL8, IL10
15response to glucocorticoid stimulusGO:05138410.3CCL2, SFTPC, TNF, IL10
16cellular response to lipopolysaccharideGO:07122210.3IL8, IL10, CSF2, CCL2
17neutrophil chemotaxisGO:03059310.3IL1B, IL8, CSF3R, CCL2
18MAPK cascadeGO:00016510.2IL1B, TNF, CCL2
19respiratory gaseous exchangeGO:00758510.2SFTPA1, SFTPC, SFTPD, SFTPB, CSF2RB
20regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.2TNF, IL1B
21chemotaxisGO:00693510.2CCL4, CCL2, DEFB1, CXCR1
22positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.1IL1B, IL10, TNF
23organ morphogenesisGO:00988710.1TNF, SFTPB, CCL2
24cell-cell signalingGO:00726710.0CCL4, IL3, IL10, IL1B
25immune responseGO:0069559.9CCL4, CSF2, DEFB1, IL3, IL8, IL1B
26positive regulation of synaptic transmissionGO:0508069.9TNF, CCL2
27inflammatory responseGO:0069549.7IL1B, CCL4, CCL2, CSF1, TNF, CXCR1
28signal transductionGO:0071659.5CCL4, CCL2, CSF3R, CSF2RB, IL8, IL1B

Molecular functions related to Pulmonary Alveolar Proteinosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.0IL8, CCL2, CCL4
2growth factor activityGO:0080839.7CSF2, CSF1, IL3, IL10
3cytokine activityGO:0051259.4IL1B, IL10, IL3, TNF, CSF1, CSF2

Products for genes affiliated with Pulmonary Alveolar Proteinosis

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  • Antibodies
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Sources for Pulmonary Alveolar Proteinosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet