MCID: PLM032
MIFTS: 47

Pulmonary Blastoma malady

Respiratory, Cancer categories

Summaries for Pulmonary Blastoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

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Disease Ontology:8 An embryoma and malignant neoplasm of lung that derives from tissues of the lung and derives from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). it is most commonly effects children.

MalaCards: Pulmonary Blastoma, also known as blastoma of lung, is related to adenocarcinoma and adenoma, and has symptoms including radiologic lung abnormalities/changes, thoracic/chest pain and cough. An important gene associated with Pulmonary Blastoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Colorectal Cancer Metastasis and Apoptosis Pathway. The compounds vincristine and etoposide have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and muscle.

Wikipedia:64 Pleuropulmonary blastoma (PPB) is a rare cancer originating in the lung or pleural cavity. It occurs... more...

Aliases & Classifications for Pulmonary Blastoma

Sources:
8Disease Ontology, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Respiratory


Characteristics (Orphanet epidemiological data):

49
pulmonary blastoma:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

pulmonary blastoma 8 45 49 61
blastoma of lung 8
pneumoblastoma 49


External Ids:

Disease Ontology8 DOID:4765
NCIt40 C3732
SNOMED-CT57 189815007, 43149009
MeSH35 D018202
ICD10 via Orphanet26 C34

Related Diseases for Pulmonary Blastoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pulmonary Blastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.3VIM, CTNNB1, EGFR, CGB, NKX2-1, SYP
2adenoma30.1CTNNB1, CGB, NKX2-1, SYP, KRAS, TP53
3blastoma11.2
4classic pulmonary blastoma10.6
5pleuropulmonary blastoma10.6
6epithelial predominant pulmonary blastoma10.3
7embryoma10.2
8spindle cell carcinoma10.2
9pulmonary systemic sclerosis10.1
10small cell carcinoma10.1
11bronchitis10.1
12hypercalcemia10.1
13bronchogenic carcinoma10.1
14embryonal sarcoma10.1
15pulmonary sequestration10.1
16hemangioma10.0NKX2-1
17thymoma10.0NKX2-1
18pituitary adenoma10.0SYP
19peutz-jeghers syndrome10.0CTNNB1
20hemangioblastoma10.0SYP
21pilocytic astrocytoma10.0SYP
22craniopharyngioma10.0CTNNB1
23paraganglioma10.0SYP
24subependymal giant cell astrocytoma10.0SYP
25turcot syndrome10.0CTNNB1
26ovarian small cell carcinoma10.0TTF1
27melanotic neuroectodermal tumor10.0SYP
28adrenocortical carcinoma10.0TP53
29neurofibromatosis10.0KRAS
30cystadenoma10.0KRAS
31pineoblastoma10.0SYP
32liver cirrhosis10.0KRAS
33alzheimer's disease10.0SYP
34pancreatitis10.0KRAS
35papilloma10.0TP53
36gastritis10.0TP53
37dysembryoplastic neuroepithelial tumor10.0SYP
38gastrointestinal stromal tumor10.0VIM
39leiomyoma10.0VIM
40cervical squamous cell carcinoma10.0KRAS
41hepatitis10.0KRAS
42malignant fibroxanthoma10.0TP53
43angiomyolipoma10.0VIM
44hepatitis c10.0KRAS
45acute leukemia10.0KRAS
46choroid plexus papilloma10.0TP53
47ganglioneuroblastoma10.0SYP
48angiosarcoma10.0VIM
49hepatoblastoma10.0CTNNB1
50thymic carcinoma10.0SYP, NKX2-1

Graphical network of the top 20 diseases related to Pulmonary Blastoma:



Diseases related to pulmonary blastoma

Clinical Features for Pulmonary Blastoma

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 10)
  • radiologic lung abnormalities/changes
  • thoracic/chest pain
  • cough
  • hemoptysis
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • repeat respiratory infections
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax

Drugs & Therapeutics for Pulmonary Blastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Blastoma

Drug clinical trials:

Search ClinicalTrials for Pulmonary Blastoma

Search NIH Clinical Center for Pulmonary Blastoma

Search CenterWatch for Pulmonary Blastoma

Genetic Tests for Pulmonary Blastoma

Anatomical Context for Pulmonary Blastoma

Animal Models for Pulmonary Blastoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pulmonary Blastoma

Sources:
51PubMed
See all sources

Articles related to Pulmonary Blastoma:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Pulmonary blastoma in a young adult. (23008928)
2012
2
Expression and mutation analysis of EGFR, c-KIT, and I^-catenin in pulmonary blastoma. (21292787)
2011
3
Classic biphasic pulmonary blastoma: a case report and review of the literature. (21513998)
2011
4
Pulmonary blastoma with yolk sac elements. (21045461)
2010
5
Radical resection of a pulmonary blastoma involving the pulmonary artery. (18579394)
2008
6
Prognostic factors in pleuro-pulmonary blastoma. (16619221)
2007
7
A patient with shortness of breath and a left hilar mass. Biphasic pulmonary blastoma. (16683903)
2006
8
Solitary brain metastasis from classic biphasic pulmonary blastoma: a case report and review of the literature. (17202827)
2006
9
Cyopathologic and histologic features of biphasic pulmonary blastoma: a case report. (15717762)
2005
10
Case report: pulmonary blastoma: presentation of two atypical cases and review of the literature. (15845939)
2005
11
Pulmonary blastoma. (16363721)
2005
12
Thyroid transcription factor-1 expression in pulmonary blastoma. (15140003)
2004
13
Pulmonary blastoma: radiologic findings in five patients. (15050223)
2004
14
Clinical-pathologic conference in general thoracic surgery: pulmonary blastoma. (14665988)
2003
15
Pulmonary blastoma: report of two cases. (11381509)
2001
16
Pulmonary blastoma: diagnostic and therapeutic aspects. (10415291)
1999
17
Pulmonary blastoma: report of a case. (10211577)
1999
18
Radical resection of a pulmonary blastoma involving the mediastinum. (10443527)
1999
19
Pulmonary blastoma. (9495909)
1998
20
Pulmonary blastoma. (9663550)
1998
21
Pulmonary blastoma. (9255019)
1997
22
Pulmonary blastoma with fatal hypercalcemia. (9154681)
1997
23
Uncertain role of high dose chemotherapy with autologous stem cell support in pediatric pleuro-pulmonary blastoma (PPB) (8950342)
1997
24
Resection and adjuvant chemotherapy of pulmonary blastoma. A case report. (8697409)
1996
25
Neonatal pulmonary blastoma. (24057720)
1996
26
Pulmonary blastoma: an ultrastructural and immunohistochemical study with special reference to nuclear filament aggregation. (8597206)
1995
27
Case of the season. Pulmonary blastoma. (7570076)
1995
28
Pulmonary blastoma in an adult presenting as a chronic loculated effusion: a diagnostic problem. (8091334)
1994
29
Pleuropulmonary blastoma is THE pulmonary blastoma of childhood. (7809508)
1994
30
Ga-67 scintigraphy in pulmonary blastoma in a child. (8432054)
1993
31
Radiological case of the month. Pulmonary blastoma. (8488810)
1993
32
Pulmonary blastoma: a rare case of childhood malignancy. (1323822)
1992
33
Childhood pulmonary blastoma: a pleuropulmonary variant of the adult-type pulmonary blastoma. (1720893)
1991
34
Pulmonary blastoma: a 12-year follow-up. (2067373)
1991
35
Pulmonary blastoma with malignant melanoma component. (2222150)
1990
36
Pulmonary blastoma--report of a case. (2848950)
1988
37
Pulmonary blastoma in a neonate. (2854159)
1988
38
Pulmonary blastoma. Case report and literature review of chemotherapy experience. (6370414)
1984
39
Pulmonary blastoma associated with cystic lung disease. (6895712)
1982
40
Chemotherapy of pulmonary blastoma: a case report and review of the literature. (7062896)
1982
41
Pulmonary blastoma. An ultrastructural study of a case and its transplanted tumor in athymic nude mice. (7417940)
1980
42
Pulmonary blastoma: review of published cases from world literature with a case report. (549857)
1979
43
Pulmonary blastoma in a child. (110053)
1979
44
Pulmonary blastoma: A light and electron microscopic study. (974996)
1976
45
Pulmonary blastoma. (979321)
1976
46
Pulmonary blastoma: cytopathologic and histopathologic findings. (183437)
1976
47
Pulmonary blastoma: a report of two cases and a review of the literature. (1013949)
1976
48
Roentgen manifestations of pulmonary blastoma. (5041154)
1972
49
Pulmonary blastoma (embryonal sarcoma of the lung). (4325327)
1971
50
Pulmonary blastoma. (5411455)
1970

Genetic Variations for Pulmonary Blastoma

Expression for genes affiliated with Pulmonary Blastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pulmonary Blastoma

Search GEO for disease gene expression data for Pulmonary Blastoma.

Pathways for genes affiliated with Pulmonary Blastoma

Sources:
52QIAGEN, 60Tocris Bioscience, 12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 56SinoBiological, 50PharmGKB, 53R&D Systems
See all sources

Pathways related to Pulmonary Blastoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9EGFR
2
Hide members
9.7KRAS, CTNNB1
39.6CTNNB1, VIM
4
Hide members
9.4KRAS, EGFR
59.4KRAS, EGFR
69.4EGFR, KRAS
7
Hide members
9.2TP53, KRAS
8
Development Endothelin-1/EDNRA signaling
Hide members
9.1CTNNB1, EGFR, KRAS
9
Hide members
9.1KRAS, EGFR, CTNNB1
108.9CTNNB1, KRAS, TP53
118.9TP53, KRAS, CTNNB1
12
Hide members
8.9TP53, KRAS, CTNNB1
138.8TP53, CTNNB1, VIM
148.7CTNNB1, EGFR, TP53
158.7TP53, EGFR, CTNNB1
168.7TP53, EGFR, CTNNB1
17
Hide members
8.6TP53, KRAS, EGFR
18
Hide members
8.6EGFR, KRAS, TP53
198.6EGFR, KRAS, TP53
208.6EGFR, KRAS, TP53
218.5TP53, EGFR, VIM
22
Hide members
8.2TP53, KRAS, EGFR, CTNNB1
23
Hide members
8.2TP53, KRAS, EGFR, CTNNB1
248.2CTNNB1, EGFR, KRAS, TP53
258.2CTNNB1, EGFR, KRAS, TP53
268.2CTNNB1, EGFR, KRAS, TP53
278.2CTNNB1, EGFR, KRAS, TP53
288.1TP53, KRAS, EGFR, VIM

Compounds for genes affiliated with Pulmonary Blastoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB, 29IUPHAR
See all sources

Compounds related to Pulmonary Blastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1vincristine45 50 1112.2VIM
2etoposide45 50 60 1112.9VIM, CGB
3s 100459.8VIM, SYP
4panitumumab45 50 1111.7EGFR, KRAS
5mucicarmine459.7VIM, NKX2-1, SYP
6b 723459.7SYP, NKX2-1, VIM
7reticulin459.6VIM, SYP
8hematoxylin459.6SYP, NKX2-1, VIM
9cetuximab45 50 1111.5CTNNB1, EGFR, KRAS
10leucovorin45 50 1111.4KRAS, CGB, EGFR
11formaldehyde45 2410.4SYP, NKX2-1, VIM
124-hydroxytamoxifen459.3VIM, CTNNB1, EGFR
13gnrh459.3VIM, CTNNB1, CGB, NKX2-1
14crcs459.3TP53, KRAS, CTNNB1
15bleomycin45 1110.2TP53, CGB, CTNNB1
16roscovitine459.2TP53, CTNNB1, VIM
17aristolochic acid45 210.1TP53, VIM
18nocodazole45 1110.1TP53, CTNNB1, VIM
19imatinib45 50 1111.1KRAS, EGFR, CTNNB1
20cyclic amp45 2410.0VIM, CGB, NKX2-1, SYP
21adpribose459.0TP53, EGFR, CTNNB1
22adriamycin459.0VIM, CTNNB1, TP53
23geldanamycin45 50 60 1112.0CTNNB1, EGFR, TP53
24gefitinib45 50 1111.0VIM, CTNNB1, EGFR, KRAS
25oxaliplatin45 50 1111.0TP53, KRAS, EGFR
26temozolomide45 119.9VIM, EGFR, TP53
27irinotecan45 50 1110.9TP53, KRAS, EGFR
28genistein45 29 60 2 11 2413.9VIM, CTNNB1, EGFR, SYP
29rapamycin458.9KRAS, EGFR, CTNNB1, VIM
30mg 13245 609.9TP53, EGFR, CTNNB1
31phosphoinositide458.8VIM, CTNNB1, EGFR, KRAS
32thymidylate458.7TP53, EGFR, VIM
33paclitaxel45 50 1110.7TP53, KRAS, EGFR, CTNNB1
345fluorouracil458.6CTNNB1, EGFR, KRAS, TP53
35testosterone45 60 11 2411.6VIM, CTNNB1, EGFR, CGB, SYP
36curcumin458.6CTNNB1, EGFR, TP53
37retinoid458.6VIM, CTNNB1, EGFR, TP53
38ly294002458.6CTNNB1, EGFR, KRAS, TP53
39sb 20358045 609.5VIM, CTNNB1, EGFR, TP53
40tamoxifen45 50 29 1111.5VIM, CTNNB1, EGFR, TP53
41doxorubicin45 50 1110.5VIM, CTNNB1, EGFR, TP53
425-aza-2deoxycytidine458.5TP53, CTNNB1, VIM
43oligonucleotide458.4VIM, CTNNB1, NKX2-1, KRAS, TP53
44h2o2458.4VIM, CTNNB1, SYP, KRAS, TP53
45cisplatin45 50 60 1110.9CTNNB1, EGFR, CGB, SYP, KRAS, TP53
46progesterone45 60 29 11 2411.5VIM, CTNNB1, EGFR, CGB, NKX2-1, SYP
47paraffin457.5TP53, VIM, CTNNB1, EGFR, NKX2-1, SYP
48retinoic acid45 248.5VIM, CTNNB1, EGFR, NKX2-1, SYP, KRAS
49serine457.4VIM, CTNNB1, EGFR, NKX2-1, SYP, KRAS
50vegf457.4VIM, CTNNB1, EGFR, CGB, SYP, KRAS

GO Terms for genes affiliated with Pulmonary Blastoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Pulmonary Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial tube branching involved in lung morphogenesisGO:0604419.9NKX2-1, CTNNB1
2regulation of long-term neuronal synaptic plasticityGO:0481699.6KRAS, SYP
3cerebral cortex cell migrationGO:0217959.6NKX2-1, EGFR
4T cell differentiation in thymusGO:0330779.3TP53, CTNNB1
5negative regulation of DNA replicationGO:0081569.0TTF1, TP53
6positive regulation of transcription from RNA polymerase II promoterGO:0459448.1TP53, NKX2-1, EGFR, CTNNB1

Molecular functions related to Pulmonary Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:0442128.7TP53, NKX2-1, CTNNB1
2enzyme bindingGO:0198998.7TP53, EGFR, CTNNB1
3chromatin bindingGO:0036828.2TP53, TTF1, EGFR, CTNNB1
4identical protein bindingGO:0428028.0VIM, EGFR, SYP, TP53

Products for genes affiliated with Pulmonary Blastoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pulmonary Blastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet