MCID: PLM032
MIFTS: 58

Pulmonary Blastoma malady

Respiratory diseases, Cancer diseases categories

Summaries for Pulmonary Blastoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An embryoma and malignant neoplasm of lung that derives from tissues of the lung and derives from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). it is most commonly effects children.

MalaCards: Pulmonary Blastoma, also known as blastoma of lung, is related to adenocarcinoma and sarcoma, and has symptoms including radiologic lung abnormalities/changes, hemoptysis and abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax. An important gene associated with Pulmonary Blastoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Colorectal Cancer Metastasis and Apoptosis Pathway. The compounds vincristine and etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, fetal lung and thyroid, and related mouse phenotypes are nervous system and muscle.

Wikipedia:63 Pleuropulmonary blastoma (PPB) is a rare cancer originating in the lung or pleural cavity. It occurs... more...

Aliases & Classifications for Pulmonary Blastoma

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Sources:
8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
pulmonary blastoma:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

pulmonary blastoma 8 44 48 60
blastoma of lung 8
pneumoblastoma 48


External Ids:

Disease Ontology8 DOID:4765
NCIt39 C3732
MeSH34 D018202
SNOMED-CT56 189815007, 43149009
ICD10 via Orphanet26 C34
SNOMED-CT via Orphanet57 43149009

Related Diseases for Pulmonary Blastoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Blastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.2TP53, CTNNB1, EGFR, CGB, NKX2-1, VIM
2sarcoma30.0VIM, CGB, TP53, KRAS
3lung adenocarcinoma30.0EGFR, TP53, KRAS, CTNNB1, NKX2-1
4melanoma30.0TP53, KRAS, VIM, NKX2-1, CTNNB1, CGB
5blastoma11.2
6classic pulmonary blastoma10.6
7pleuropulmonary blastoma10.6
8epithelial predominant pulmonary blastoma10.3
9embryoma10.2
10spindle cell carcinoma10.2
11pneumothorax10.2
12pulmonary systemic sclerosis10.1
13small cell carcinoma10.1
14bronchitis10.1
15hypercalcemia10.1
16bronchogenic carcinoma10.1
17laryngitis10.1
18lung sarcoma10.1
19thyroiditis10.1
20hemangioma10.0NKX2-1
21thymoma10.0NKX2-1
22pituitary adenoma10.0SYP
23peutz-jeghers syndrome10.0CTNNB1
24hemangioblastoma10.0SYP
25pilocytic astrocytoma10.0SYP
26craniopharyngioma10.0CTNNB1
27paraganglioma10.0SYP
28subependymal giant cell astrocytoma10.0SYP
29turcot syndrome10.0CTNNB1
30ovarian small cell carcinoma10.0TTF1
31melanotic neuroectodermal tumor10.0SYP
32adrenocortical carcinoma10.0TP53
33neurofibromatosis10.0KRAS
34cystadenoma10.0KRAS
35pineoblastoma10.0SYP
36liver cirrhosis10.0KRAS
37alzheimer's disease10.0SYP
38pancreatitis10.0KRAS
39papilloma10.0TP53
40gastritis10.0TP53
41dysembryoplastic neuroepithelial tumor10.0SYP
42gastrointestinal stromal tumor10.0VIM
43leiomyoma10.0VIM
44cervical squamous cell carcinoma10.0KRAS
45hepatitis10.0KRAS
46malignant fibroxanthoma10.0TP53
47angiomyolipoma10.0VIM
48hepatitis c10.0KRAS
49acute leukemia10.0KRAS
50choroid plexus papilloma10.0TP53

Graphical network of the top 20 diseases related to Pulmonary Blastoma:



Diseases related to pulmonary blastoma

Clinical Features for Pulmonary Blastoma

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Sources:
48Orphanet
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Symptoms:

48 (show all 10)
  • radiologic lung abnormalities/changes
  • hemoptysis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • cough
  • thoracic/chest pain
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • repeat respiratory infections
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction

Drugs & Therapeutics for Pulmonary Blastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pulmonary Blastoma

Drug clinical trials:

Search ClinicalTrials for Pulmonary Blastoma

Search NIH Clinical Center for Pulmonary Blastoma

Search CenterWatch for Pulmonary Blastoma

Genetic Tests for Pulmonary Blastoma

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Anatomical Context for Pulmonary Blastoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pulmonary Blastoma:

32
Lung, Fetal lung, Thyroid, Bronchial epithelium, Lymph node, Brain, Liver, Ovary

Animal Models for Pulmonary Blastoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pulmonary Blastoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.0SYP, NKX2-1
2MP:00053699.7TP53
3MP:00053799.1TP53, KRAS
4MP:00053888.5CTNNB1, EGFR, TP53, KRAS
5MP:00053898.4EGFR, KRAS, CTNNB1, TP53
6MP:00030128.2NKX2-1, TP53, EGFR, CTNNB1, SYP
7MP:00020068.1CTNNB1, EGFR, NKX2-1, KRAS, TP53
8MP:00053818.0TP53, NKX2-1, EGFR, CTNNB1, KRAS
9MP:00028737.9CTNNB1, EGFR, KRAS, TP53, SYP
10MP:00053917.7EGFR, VIM, TP53, KRAS, CTNNB1
11MP:00053857.5KRAS, NKX2-1, EGFR, CTNNB1, VIM, TP53
12MP:00053807.4KRAS, CTNNB1, EGFR, VIM, TP53

Publications for Pulmonary Blastoma

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Sources:
50PubMed
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Articles related to Pulmonary Blastoma:

(show top 50)    (show all 193)
idTitleAuthorsYear
1
Adult biphasic pulmonary blastoma. (23427368)
2013
2
Expression and mutation analysis of EGFR, c-KIT, and I^-catenin in pulmonary blastoma. (21292787)
2011
3
Establishment and phenotypic characterization of the first human pulmonary blastoma cell line. (20724021)
2011
4
Pulmonary blastoma with yolk sac elements. (21045461)
2010
5
A rare association; pulmonary blastoma developing on extrapulmonary sequestration basis. (20395246)
2010
6
Preoperative radiation therapy and chemotherapy for pulmonary blastoma: a case report. (20101153)
2010
7
Pulmonary blastoma metastatic to the ovary. (19047906)
2009
8
Clinical, pathological and immunohistochemical features of a pulmonary blastoma in a horse. (19202177)
2009
9
Pulmonary blastoma with endobronchial growth. (19333073)
2009
10
Biphasic pulmonary blastoma with germ cell differentiation in a 36-year-old man. (18827617)
2008
11
Clonality and heterogeneity of pulmonary blastoma from the viewpoint of genetic alterations: a case report. (17350138)
2007
12
Clinicopathological and immunohistochemical features of pulmonary blastoma: analysis of 4 cases and review of the literature]. (17672968)
2007
13
Combined small cell carcinoma with pulmonary blastoma and adenocarcinoma: case report and clonality analysis. (17046168)
2006
14
Pulmonary blastoma within bronchioloalveolar cell carcinoma. (16635096)
2006
15
Biphasic pulmonary blastoma presenting as endobronchial polyp with a long stalk. (15942110)
2005
16
Pleuropulmonary blastoma in childhood. A malignant degeneration of pulmonary cysts. (15185105)
2004
17
Unexpected response of a pulmonary blastoma on radiotherapy: a case report and review of the literature. (11955657)
2002
18
Pulmonary blastoma after liver transplant: a case report. (12088262)
2002
19
Pulmonary blastoma: report of five cases and identification of clinical features suggestive of the disease. (12414034)
2002
20
Extension of a pulmonary blastoma into the left atrium. (11393507)
2001
21
Pulmonary blastoma: diagnostic and therapeutic aspects. (10415291)
1999
22
Alpha-fetoprotein producing pulmonary blastoma in a patient with systemic sclerosis: pathogenetic analysis. (9648976)
1998
23
Resection and adjuvant chemotherapy of pulmonary blastoma. A case report. (8697408)
1996
24
A diagnostic dilemma: pulmonary blastoma. (9018979)
1996
25
Pulmonary blastoma: a rare lung malignancy. (8882990)
1996
26
Pulmonary blastoma presenting as a solitary lip metastasis: case report and review of the literature. (7552426)
1995
27
Combined chemotherapy and radiotherapy in advanced pulmonary blastoma. (7597683)
1995
28
Pulmonary blastoma as a unique cause of fatal respiratory distress in a newborn. (7666331)
1995
29
Pleuropulmonary blastoma (pulmonary blastoma of childhood): genetic link with other embryonal malignancies? (8063284)
1994
30
Giant pulmonary blastoma. (8077035)
1993
31
Management of pulmonary blastoma in children. (8476159)
1993
32
Pulmonary blastoma--a rare tumour. (1333313)
1992
33
Pulmonary blastoma with germ cell (yolk sac) differentiation: report of two cases. (1722041)
1991
34
Diagnosis of pulmonary blastoma by fine-needle aspiration biopsy: cytologic and immunocytochemical findings. (1709089)
1991
35
Pulmonary blastoma. An immunohistochemical analysis with comparison with fetal lung in its pseudoglandular stage. (2301281)
1990
36
Pulmonary blastoma--report of a case. (2848950)
1988
37
Pulmonary blastoma, report of three cases and a review of the literature. (2967836)
1988
38
Laryngeal blastoma. A light and electron microscopic study of a novel entity analogous to pulmonary blastoma. (2994458)
1985
39
Pulmonary blastoma, a true congenital neoplasm. (6309644)
1983
40
Pulmonary blastoma. A clinico-pathological study of eleven cases. (7386208)
1980
41
Pulmonary blastoma/ report of a case. (633061)
1978
42
Pulmonary blastoma: an ultrastructural study with a brief review of literature and a discussion of pathogenesis. (188536)
1977
43
Pulmonary blastoma. (188222)
1976
44
Pulmonary blastoma. (941110)
1976
45
Letter: Pulmonary blastoma. (4429265)
1974
46
Pulmonary blastoma. (4355012)
1973
47
Pulmonary blastoma, report of a case. (4515901)
1973
48
Pulmonary blastoma. A case report in an infant and review of the literature. (5013920)
1972
49
Pulmonary blastoma. (5571477)
1971
50
Pulmonary blastoma. (5697348)
1968

Genetic Variations for Pulmonary Blastoma

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Expression for genes affiliated with Pulmonary Blastoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Blastoma

Search GEO for disease gene expression data for Pulmonary Blastoma.

Pathways for genes affiliated with Pulmonary Blastoma

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Sources:
51QIAGEN, 59Tocris Bioscience, 12EMD Millipore, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 49PharmGKB
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Pathways related to Pulmonary Blastoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9EGFR
2
Hide members
9.7KRAS, CTNNB1
39.6CTNNB1, VIM
49.4KRAS, EGFR
5
Hide members
9.4EGFR, KRAS
69.4EGFR, KRAS
7
Hide members
9.2KRAS, TP53
8
Hide members
9.1KRAS, CTNNB1, EGFR
9
Development Endothelin-1/EDNRA signaling
Hide members
9.1KRAS, CTNNB1, EGFR
108.9CTNNB1, TP53, KRAS
118.9TP53, KRAS, CTNNB1
12
Hide members
8.9CTNNB1, TP53, KRAS
138.8VIM, TP53, CTNNB1
148.7CTNNB1, EGFR, TP53
158.7TP53, EGFR, CTNNB1
168.7TP53, EGFR, CTNNB1
178.6TP53, KRAS, EGFR
18
Hide members
8.6TP53, EGFR, KRAS
198.6EGFR, TP53, KRAS
20
Hide members
8.6KRAS, EGFR, TP53
218.5TP53, VIM, EGFR
228.2TP53, KRAS, EGFR, CTNNB1
238.2KRAS, TP53, CTNNB1, EGFR
24
Hide members
8.2CTNNB1, TP53, KRAS, EGFR
258.2TP53, KRAS, EGFR, CTNNB1
26
Hide members
8.2EGFR, TP53, KRAS, CTNNB1
278.2TP53, EGFR, KRAS, CTNNB1
288.1TP53, VIM, EGFR, KRAS

Compounds for genes affiliated with Pulmonary Blastoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB, 28IUPHAR
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Compounds related to Pulmonary Blastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.2VIM
2etoposide44 49 59 1112.9CGB, VIM
3s 100449.8SYP, VIM
4panitumumab44 49 1111.7EGFR, KRAS
5mucicarmine449.7NKX2-1, VIM, SYP
6b 723449.7SYP, VIM, NKX2-1
7reticulin449.6SYP, VIM
8hematoxylin449.6NKX2-1, SYP, VIM
9cetuximab44 49 1111.5KRAS, EGFR, CTNNB1
10leucovorin44 49 1111.4EGFR, KRAS, CGB
11formaldehyde44 2410.4NKX2-1, SYP, VIM
124-hydroxytamoxifen449.3VIM, CTNNB1, EGFR
13gnrh449.3NKX2-1, CGB, CTNNB1, VIM
14crcs449.3CTNNB1, TP53, KRAS
15bleomycin44 1110.2CGB, CTNNB1, TP53
16roscovitine449.2VIM, CTNNB1, TP53
17aristolochic acid44 210.1VIM, TP53
18nocodazole44 1110.1TP53, CTNNB1, VIM
19imatinib44 49 1111.1CTNNB1, KRAS, EGFR
20cyclic amp44 2410.0NKX2-1, CGB, SYP, VIM
21adpribose449.0EGFR, TP53, CTNNB1
22adriamycin449.0TP53, CTNNB1, VIM
23geldanamycin44 49 59 1112.0CTNNB1, TP53, EGFR
24gefitinib44 49 1111.0KRAS, CTNNB1, EGFR, VIM
25oxaliplatin44 49 1111.0EGFR, KRAS, TP53
26temozolomide44 119.9VIM, TP53, EGFR
27irinotecan44 49 1110.9TP53, KRAS, EGFR
28genistein44 28 59 2 11 2413.9VIM, EGFR, SYP, CTNNB1
29rapamycin448.9VIM, KRAS, CTNNB1, EGFR
30mg 13244 599.9EGFR, CTNNB1, TP53
31phosphoinositide448.8EGFR, CTNNB1, VIM, KRAS
32thymidylate448.7EGFR, TP53, VIM
33paclitaxel44 49 1110.7KRAS, EGFR, TP53, CTNNB1
345fluorouracil448.6TP53, CTNNB1, EGFR, KRAS
35testosterone44 59 11 2411.6EGFR, SYP, CGB, CTNNB1, VIM
36curcumin448.6TP53, CTNNB1, EGFR
37retinoid448.6CTNNB1, TP53, VIM, EGFR
38ly294002448.6KRAS, CTNNB1, EGFR, TP53
39sb 20358044 599.5VIM, TP53, EGFR, CTNNB1
40tamoxifen44 49 28 1111.5VIM, CTNNB1, EGFR, TP53
41doxorubicin44 49 1110.5TP53, VIM, EGFR, CTNNB1
425-aza-2deoxycytidine448.5TP53, VIM, CTNNB1
43oligonucleotide448.4NKX2-1, TP53, VIM, CTNNB1, KRAS
44h2o2448.4VIM, TP53, SYP, KRAS, CTNNB1
45cisplatin44 49 59 1110.9EGFR, CGB, SYP, CTNNB1, TP53, KRAS
46progesterone44 59 28 11 2411.5CGB, SYP, TP53, VIM, EGFR, CTNNB1
47paraffin447.5NKX2-1, KRAS, SYP, VIM, CTNNB1, TP53
48retinoic acid44 248.5EGFR, CTNNB1, SYP, TP53, VIM, KRAS
49serine447.4KRAS, SYP, CTNNB1, NKX2-1, EGFR, VIM
50vegf447.4VIM, EGFR, CGB, SYP, KRAS, TP53

GO Terms for genes affiliated with Pulmonary Blastoma

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Sources:
16Gene Ontology
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Biological processes related to Pulmonary Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial tube branching involved in lung morphogenesisGO:0604419.9NKX2-1, CTNNB1
2regulation of long-term neuronal synaptic plasticityGO:0481699.6KRAS, SYP
3cerebral cortex cell migrationGO:0217959.6NKX2-1, EGFR
4T cell differentiation in thymusGO:0330779.3TP53, CTNNB1
5negative regulation of DNA replicationGO:0081569.0TTF1, TP53
6positive regulation of transcription from RNA polymerase II promoterGO:0459448.1TP53, NKX2-1, EGFR, CTNNB1

Molecular functions related to Pulmonary Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:0442128.7TP53, NKX2-1, CTNNB1
2enzyme bindingGO:0198998.7CTNNB1, EGFR, TP53
3chromatin bindingGO:0036828.2TP53, TTF1, EGFR, CTNNB1
4identical protein bindingGO:0428028.0VIM, EGFR, SYP, TP53

Products for genes affiliated with Pulmonary Blastoma

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  • Antibodies
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  • Lysates
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Sources for Pulmonary Blastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet