MCID: PLM032
MIFTS: 58

Pulmonary Blastoma malady

Respiratory diseases, Cancer diseases categories

Summaries for Pulmonary Blastoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An embryoma and malignant neoplasm of lung that derives from tissues of the lung and derives from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). it is most commonly effects children.

MalaCards: Pulmonary Blastoma, also known as blastoma of lung, is related to adenocarcinoma and sarcoma, and has symptoms including abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax, fever/chilling and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Pulmonary Blastoma is NKX2-1 (NK2 homeobox 1), and among its related pathways are Colorectal Cancer Metastasis and Apoptosis Pathway. The compounds vincristine and etoposide have been mentioned in the context of this disorder. Affiliated tissues include lung, fetal lung and ovary, and related mouse phenotypes are nervous system and muscle.

Wikipedia:63 Pleuropulmonary blastoma (PPB) is a rare cancer originating in the lung or pleural cavity. It occurs... more...

Aliases & Classifications for Pulmonary Blastoma

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
pulmonary blastoma:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

pulmonary blastoma 8 44 48 60
blastoma of lung 8
pneumoblastoma 48


External Ids:

Disease Ontology8 DOID:4765
NCIt39 C3732
MeSH34 D018202
SNOMED-CT56 189815007, 43149009
ICD10 via Orphanet26 C34
SNOMED-CT via Orphanet57 43149009

Related Diseases for Pulmonary Blastoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pulmonary Blastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.2TP53, CTNNB1, EGFR, CGB, NKX2-1, VIM
2sarcoma30.0VIM, CGB, TP53, KRAS
3lung adenocarcinoma30.0EGFR, TP53, KRAS, CTNNB1, NKX2-1
4melanoma30.0TP53, KRAS, VIM, NKX2-1, CTNNB1, CGB
5blastoma11.2
6classic pulmonary blastoma10.6
7pleuropulmonary blastoma10.6
8epithelial predominant pulmonary blastoma10.3
9embryoma10.2
10spindle cell carcinoma10.2
11pneumothorax10.2
12pulmonary systemic sclerosis10.1
13small cell carcinoma10.1
14bronchitis10.1
15hypercalcemia10.1
16bronchogenic carcinoma10.1
17laryngitis10.1
18lung sarcoma10.1
19thyroiditis10.1
20hemangioma10.0NKX2-1
21thymoma10.0NKX2-1
22pituitary adenoma10.0SYP
23peutz-jeghers syndrome10.0CTNNB1
24hemangioblastoma10.0SYP
25pilocytic astrocytoma10.0SYP
26craniopharyngioma10.0CTNNB1
27paraganglioma10.0SYP
28subependymal giant cell astrocytoma10.0SYP
29turcot syndrome10.0CTNNB1
30ovarian small cell carcinoma10.0TTF1
31melanotic neuroectodermal tumor10.0SYP
32adrenocortical carcinoma10.0TP53
33neurofibromatosis10.0KRAS
34cystadenoma10.0KRAS
35pineoblastoma10.0SYP
36liver cirrhosis10.0KRAS
37alzheimer's disease10.0SYP
38pancreatitis10.0KRAS
39papilloma10.0TP53
40gastritis10.0TP53
41dysembryoplastic neuroepithelial tumor10.0SYP
42gastrointestinal stromal tumor10.0VIM
43leiomyoma10.0VIM
44cervical squamous cell carcinoma10.0KRAS
45hepatitis10.0KRAS
46malignant fibroxanthoma10.0TP53
47angiomyolipoma10.0VIM
48hepatitis c10.0KRAS
49acute leukemia10.0KRAS
50choroid plexus papilloma10.0TP53

Graphical network of the top 20 diseases related to Pulmonary Blastoma:



Diseases related to pulmonary blastoma

Clinical Features for Pulmonary Blastoma

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Sources:
48Orphanet
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Symptoms:

48 (show all 10)
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • fever/chilling
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • repeat respiratory infections
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • hemoptysis
  • cough
  • thoracic/chest pain
  • radiologic lung abnormalities/changes

Drugs & Therapeutics for Pulmonary Blastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pulmonary Blastoma

Drug clinical trials:

Search ClinicalTrials for Pulmonary Blastoma

Search NIH Clinical Center for Pulmonary Blastoma

Search CenterWatch for Pulmonary Blastoma

Genetic Tests for Pulmonary Blastoma

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Anatomical Context for Pulmonary Blastoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pulmonary Blastoma:

32
Lung, Fetal lung, Ovary, Thyroid, Liver, Brain, Lymph node, Bronchial epithelium

Animal Models for Pulmonary Blastoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pulmonary Blastoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.0SYP, NKX2-1
2MP:00053699.7TP53
3MP:00053799.1TP53, KRAS
4MP:00053888.5TP53, KRAS, EGFR, CTNNB1
5MP:00053898.4CTNNB1, EGFR, KRAS, TP53
6MP:00030128.2CTNNB1, EGFR, NKX2-1, SYP, TP53
7MP:00020068.1CTNNB1, EGFR, NKX2-1, KRAS, TP53
8MP:00053818.0CTNNB1, EGFR, NKX2-1, KRAS, TP53
9MP:00028737.9TP53, KRAS, SYP, EGFR, CTNNB1
10MP:00053917.7VIM, CTNNB1, EGFR, KRAS, TP53
11MP:00053857.5VIM, CTNNB1, EGFR, NKX2-1, KRAS, TP53
12MP:00053807.4VIM, CTNNB1, EGFR, KRAS, TP53

Publications for Pulmonary Blastoma

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Sources:
50PubMed
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Articles related to Pulmonary Blastoma:

(show top 50)    (show all 193)
idTitleAuthorsYear
1
Radiographic illusion of cardiomegaly resulting from a pulmonary blastoma in a patient imaged for evaluation of chronic bronchitis. (23887987)
2013
2
Classic Biphasic Pulmonary Blastoma Demonstrated by 18F-FDG PET/CT. (23989445)
2013
3
Primary pulmonary blastoma of monophasic variety--diagnosis and management. (23758909)
2013
4
Pulmonary blastoma with submandibular, scrotum and adrenal metastases: case report. (21447935)
2012
5
Classic pulmonary blastoma: a subtype of biphasic pulmonary blastoma. (22001215)
2012
6
Fine-needle aspiration of classic biphasic pulmonary blastoma. (19937760)
2010
7
Biphagic pulmonary blastoma with a lesion of yolk sac tumor. (17642278)
2007
8
Biphasic pulmonary blastoma: report of a case. (17392670)
2007
9
Pulmonary blastoma with renal metastasis responds to sorafenib. (17409808)
2007
10
Survival of biphasic pulmonary blastoma. (16332433)
2006
11
Pneumothorax and pulmonary cyst in a 2-year-old child. Pleuropulmonary blastoma. (16594758)
2006
12
Pulmonary blastoma--a rare tumor with variable presentation. (16387506)
2006
13
A rare case of classic biphasic pulmonary blastoma. (16447486)
2005
14
Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma. (15223963)
2004
15
Expression of KIT (CD117) in biphasic pulmonary blastoma. Novel data on histogenesis. (14692559)
2003
16
Pulmonary blastoma: medium-term results from a regional center. (12022552)
2002
17
Pulmonary blastoma. (11563261)
2001
18
Pulmonary blastoma in a child: report of a case. (11510607)
2001
19
Pulmonary blastoma in an adult. A case with rapid progression. (9802145)
1998
20
Case of extra pulmonary, pleuro-pulmonary blastoma in a child: pathological and cytogenetic findings. (9142208)
1997
21
Radiological case of the month. Congenital cystic adenomatoid malformation of the lung and pulmonary blastoma. (9343020)
1997
22
Resection and adjuvant chemotherapy of pulmonary blastoma: a case report. (8635054)
1995
23
Pulmonary blastoma--a case and review of literature. (8613168)
1994
24
Pulmonary blastoma in children: report of two cases and review of the literature. (7877026)
1994
25
Pulmonary blastoma. Comparison between its epithelial components and fetal bronchial epithelium. (1290326)
1992
26
Pulmonary blastoma with a topographic transition from blastic to more differentiated areas. An immunohistochemical assessment of its embryonic nature using stage-specific embryonic antigens. (1661048)
1991
27
Persistent polyclonal B lymphocytosis with Epstein-Barr virus antibodies and subsequent malignant pulmonary blastoma. (1661303)
1991
28
Pulmonary blastoma with neuroendocrine differentiation in cell morules resembling neuroepithelial bodies. (2124206)
1990
29
Role of chemotherapy in pediatric pulmonary blastoma. (2152957)
1990
30
Pulmonary blastoma. (2176642)
1990
31
Pulmonary blastoma. (2301291)
1990
32
Pulmonary blastoma. (2261408)
1990
33
Immunohistochemical characterization of pulmonary blastoma. (3369370)
1988
34
Pulmonary blastoma with rhabdomyosarcomatous differentiation: an electron microscopic and immunohistochemical study. (3337338)
1988
35
Pulmonary blastoma. Immunohistochemical and ultrastructural studies of a case. (3623437)
1987
36
Computed tomography of pulmonary blastoma in a child. (2991998)
1985
37
Pulmonary blastoma associated with cystic lesions in children. (6321934)
1984
38
Pulmonary blastoma: an ultrastructural and histochemical study. (6537093)
1984
39
Pulmonary blastoma: remission with chemotherapy. (6086368)
1984
40
Pulmonary blastoma. (6884093)
1983
41
Pulmonary blastoma in children. Two case reports and a review of the literature. (6828711)
1983
42
Pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung). (6179430)
1982
43
Pulmonary blastoma. (158135)
1979
44
Pulmonary blastoma. (231910)
1979
45
Pulmonary blastoma. Report of two cases in children. (736215)
1978
46
Pulmonary blastoma: report of two cases. (1126201)
1975
47
Pulmonary blastoma (embryoma lung). A case report with review of literature. (1193668)
1975
48
Pulmonary blastoma. A case report and review of the literature. (4811746)
1974
49
Pulmonary blastoma with a striated muscle component. (5956153)
1966
50
Pulmonary blastoma (embryoma). Report of two cases. (5931363)
1966

Genetic Variations for Pulmonary Blastoma

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Expression for genes affiliated with Pulmonary Blastoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pulmonary Blastoma

Search GEO for disease gene expression data for Pulmonary Blastoma.

Pathways for genes affiliated with Pulmonary Blastoma

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Sources:
51QIAGEN, 59Tocris Bioscience, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 55SinoBiological, 49PharmGKB, 52R&D Systems
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Pathways related to Pulmonary Blastoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9EGFR
2
Hide members
9.7KRAS, CTNNB1
39.6CTNNB1, VIM
4
Hide members
9.4KRAS, EGFR
59.4KRAS, EGFR
69.4EGFR, KRAS
7
Hide members
9.2TP53, KRAS
8
Development Endothelin-1/EDNRA signaling
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9.1CTNNB1, EGFR, KRAS
9
Hide members
9.1KRAS, EGFR, CTNNB1
108.9CTNNB1, KRAS, TP53
118.9TP53, KRAS, CTNNB1
12
Hide members
8.9TP53, KRAS, CTNNB1
138.8TP53, CTNNB1, VIM
148.7CTNNB1, EGFR, TP53
158.7TP53, EGFR, CTNNB1
168.7TP53, EGFR, CTNNB1
17
Hide members
8.6TP53, KRAS, EGFR
18
Hide members
8.6EGFR, KRAS, TP53
198.6EGFR, KRAS, TP53
208.6EGFR, KRAS, TP53
218.5TP53, EGFR, VIM
22
Hide members
8.2TP53, KRAS, EGFR, CTNNB1
23
Hide members
8.2TP53, KRAS, EGFR, CTNNB1
248.2CTNNB1, EGFR, KRAS, TP53
258.2CTNNB1, EGFR, KRAS, TP53
268.2CTNNB1, EGFR, KRAS, TP53
278.2CTNNB1, EGFR, KRAS, TP53
288.1TP53, KRAS, EGFR, VIM

Compounds for genes affiliated with Pulmonary Blastoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB, 28IUPHAR
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Compounds related to Pulmonary Blastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.2VIM
2etoposide44 49 59 1112.9CGB, VIM
3s 100449.8SYP, VIM
4panitumumab44 49 1111.7EGFR, KRAS
5mucicarmine449.7NKX2-1, VIM, SYP
6b 723449.7SYP, VIM, NKX2-1
7reticulin449.6SYP, VIM
8hematoxylin449.6NKX2-1, SYP, VIM
9cetuximab44 49 1111.5KRAS, EGFR, CTNNB1
10leucovorin44 49 1111.4EGFR, KRAS, CGB
11formaldehyde44 2410.4NKX2-1, SYP, VIM
124-hydroxytamoxifen449.3VIM, CTNNB1, EGFR
13gnrh449.3NKX2-1, CGB, CTNNB1, VIM
14crcs449.3CTNNB1, TP53, KRAS
15bleomycin44 1110.2CGB, CTNNB1, TP53
16roscovitine449.2VIM, CTNNB1, TP53
17aristolochic acid44 210.1VIM, TP53
18nocodazole44 1110.1TP53, CTNNB1, VIM
19imatinib44 49 1111.1CTNNB1, KRAS, EGFR
20cyclic amp44 2410.0NKX2-1, CGB, SYP, VIM
21adpribose449.0EGFR, TP53, CTNNB1
22adriamycin449.0TP53, CTNNB1, VIM
23geldanamycin44 49 59 1112.0CTNNB1, TP53, EGFR
24gefitinib44 49 1111.0KRAS, CTNNB1, EGFR, VIM
25oxaliplatin44 49 1111.0EGFR, KRAS, TP53
26temozolomide44 119.9VIM, TP53, EGFR
27irinotecan44 49 1110.9TP53, KRAS, EGFR
28genistein44 28 59 2 11 2413.9VIM, EGFR, SYP, CTNNB1
29rapamycin448.9VIM, KRAS, CTNNB1, EGFR
30mg 13244 599.9EGFR, CTNNB1, TP53
31phosphoinositide448.8EGFR, CTNNB1, VIM, KRAS
32thymidylate448.7EGFR, TP53, VIM
33paclitaxel44 49 1110.7KRAS, EGFR, TP53, CTNNB1
345fluorouracil448.6TP53, CTNNB1, EGFR, KRAS
35testosterone44 59 11 2411.6EGFR, SYP, CGB, CTNNB1, VIM
36curcumin448.6TP53, CTNNB1, EGFR
37retinoid448.6CTNNB1, TP53, VIM, EGFR
38ly294002448.6KRAS, CTNNB1, EGFR, TP53
39sb 20358044 599.5VIM, TP53, EGFR, CTNNB1
40tamoxifen44 49 28 1111.5VIM, CTNNB1, EGFR, TP53
41doxorubicin44 49 1110.5TP53, VIM, EGFR, CTNNB1
425-aza-2deoxycytidine448.5TP53, VIM, CTNNB1
43oligonucleotide448.4NKX2-1, TP53, VIM, CTNNB1, KRAS
44h2o2448.4VIM, TP53, SYP, KRAS, CTNNB1
45cisplatin44 49 59 1110.9EGFR, CGB, SYP, CTNNB1, TP53, KRAS
46progesterone44 59 28 11 2411.5CGB, SYP, TP53, VIM, EGFR, CTNNB1
47paraffin447.5NKX2-1, KRAS, SYP, VIM, CTNNB1, TP53
48retinoic acid44 248.5EGFR, CTNNB1, SYP, TP53, VIM, KRAS
49serine447.4KRAS, SYP, CTNNB1, NKX2-1, EGFR, VIM
50vegf447.4VIM, EGFR, CGB, SYP, KRAS, TP53

GO Terms for genes affiliated with Pulmonary Blastoma

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16Gene Ontology
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Biological processes related to Pulmonary Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial tube branching involved in lung morphogenesisGO:0604419.9NKX2-1, CTNNB1
2regulation of long-term neuronal synaptic plasticityGO:0481699.6KRAS, SYP
3cerebral cortex cell migrationGO:0217959.6NKX2-1, EGFR
4T cell differentiation in thymusGO:0330779.3TP53, CTNNB1
5negative regulation of DNA replicationGO:0081569.0TTF1, TP53
6positive regulation of transcription from RNA polymerase II promoterGO:0459448.1TP53, NKX2-1, EGFR, CTNNB1

Molecular functions related to Pulmonary Blastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:0442128.7TP53, NKX2-1, CTNNB1
2enzyme bindingGO:0198998.7TP53, EGFR, CTNNB1
3chromatin bindingGO:0036828.2TP53, TTF1, EGFR, CTNNB1
4identical protein bindingGO:0428028.0VIM, EGFR, SYP, TP53

Products for genes affiliated with Pulmonary Blastoma

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  • Antibodies
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Sources for Pulmonary Blastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet